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<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VG91</accession>
    <name>D7VG91_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide chain release factor N(5)-glutamine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.297</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">prmC</name>
        <name evidence="9" type="ORF">HMPREF0766_10010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001833.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10010"/>
    <dbReference type="EnsemblBacteria" id="EFK60066">
        <property type="protein sequence ID" value="EFK60066"/>
        <property type="gene ID" value="HMPREF0766_10010"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_3_2_10"/>
    <dbReference type="OrthoDB" id="1816476at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PrmC_N" evidence="8">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="MTS" evidence="7">
        <location>
            <begin position="118"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK60066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="285" mass="32843" checksum="BA687041F6F24E3F" modified="2010-10-05" version="1">MNSLQQYELYFTAQLTKIYDLEEAKSLFFLALEEVTGINRMQYAVRNTEAVTEEQKIQLDRILQELLRRKPIQHILKKADFYGEIFEVNEFVLIPRPETEELVHLIIGHHRSSAVPLKIIDIGTGSGCIPVILKKHMPSAHVSALDISKEAIAVAKRNAKKLGTDIHFVNADILEWEYLFTEQLYDIIVSNPPYITPKEKEDMHSNVLEFEPHLALFVEESTPLLFYETIASFALVHLKPSGDLYFEINQYYGPETANMLRKKGFSTVELIKDMHGADRMIHARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGA3</accession>
    <name>D7VGA3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lipB2</name>
        <name evidence="2" type="ORF">HMPREF0766_10022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001868.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10022"/>
    <dbReference type="EnsemblBacteria" id="EFK60078">
        <property type="protein sequence ID" value="EFK60078"/>
        <property type="gene ID" value="HMPREF0766_10022"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044538_2_1_10"/>
    <dbReference type="OrthoDB" id="1712770at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="34"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="254" mass="29142" checksum="CAEBBBD989CC95E7" modified="2010-10-05" version="1">MKITFLGTGTSQGVPVIACHCEVCQSADHRNKRLRSSVMIEFEGNNVVIDTGPDFRYQMLREEVNHLDAILMTHSHKDHIAGLDDVRAFNYQQKQSIPIYGTQALHEALKREFYYAFSDIKYPGVPQLELREIDDSQSFHLYGKEITPIEVMHFKMPVLGYRIENFAYITDAKTVSDESVEKLKGVEYLVINALQKEPHISHFTLEEAVEFANQVNPKQTYLTHISHRLGLHEEVSKELPDHIQLAYDGLSIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGD0</accession>
    <name>D7VGD0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_10049</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001940.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10049"/>
    <dbReference type="EnsemblBacteria" id="EFK60105">
        <property type="protein sequence ID" value="EFK60105"/>
        <property type="gene ID" value="HMPREF0766_10049"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_10"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="134"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="134"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK60105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="234" mass="26762" checksum="39B7AF296E779EED" modified="2010-10-05" version="1">MNEILLVEDEQNVAELVIQGLEEDGYKVIHAMDGLKALEIVRTKAVDLVILDILLPQMNGLDVCKAIRDSGYTDLPVLMLTALGSPENVVLGLDNGADDYMSKPFKLIELKARIRTLLRRKSEISKSVQSQMKNEVYRYSVLKLDDYQKVAYCNDEELNLTSTEYRLLQLFMRSPKKVFMRSELLDEVWGINFDIGSNVVDVYVNYLRRKIEKHSPMKLIHTVIGMGYVLKGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGF9</accession>
    <name>D7VGF9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002013.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10078"/>
    <dbReference type="EnsemblBacteria" id="EFK60134">
        <property type="protein sequence ID" value="EFK60134"/>
        <property type="gene ID" value="HMPREF0766_10078"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032Z8J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_569726_0_0_10"/>
    <dbReference type="OrthoDB" id="1049198at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK60134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="479" mass="56116" checksum="A56B6B6F5AAB580A" modified="2010-10-05" version="1">MKKTSSTRNTENFKDFDKQLEFIEKINSFDEFQIFLSEYLDHHVFLSKRGKKFYIDTDFHMEMDEANEISKFVFPVDDVMYETKDLHCISRRSDFKKNEGSKHSATFEVNSLQSQCFHSKSLFTTFFPVELKEIKSFHGEFETIVHKRNRTTYGYDCLLVNINGVEYHITQLKTVDNGFYVFECLQKETFENYRKVCFSIQQAIGFINGLMVGDEEYIFDSAGNLYFSNEIRQKIRSMYNPIITNPYSYLDIDREIAKDYIDKLTSISFENLSNLVSRIHTDEDFSTAILVILDASYTRSLLLVPSSFAVIIELLSKNIDTDSTEVEIPIENKALKNKIISELHTVIDNNSSTLSEAHIIKLKRRLNDINKPVSKRHLTNNEKLTRPFERLGIKLSLRDIEIIEHRNDLLHGNILMKKDNKQSDDSINLYMSYVSARLFTLISKLLLKSIGYNGYVYNQAKYLEKYMNINTDEEYFEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGG9</accession>
    <name>D7VGG9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_10088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002034.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10088"/>
    <dbReference type="EnsemblBacteria" id="EFK60144">
        <property type="protein sequence ID" value="EFK60144"/>
        <property type="gene ID" value="HMPREF0766_10088"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027633_2_1_10"/>
    <dbReference type="OrthoDB" id="1071106at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK60144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="376" mass="42824" checksum="8A38083696CF73F3" modified="2010-10-05" version="1">MSKRKVNIDNKLSPKLRLNTICPYFTMFPLSFPYRVLQKTKKTDVVYDPFCGRGTTNFAARLLGLNSYGIDSNPIAHAVAQSKLQYVDQQQIYSRCLNIIEEYDAIDIPQGDFWELAYHPNTLISICKLRNYFINKELLDDIDISLRALILGILHGPTMKTQPSYLSNQMPRTFSTKPNYSIQYWRKNMLLPAEVNLLGLVERRSKYIFNEHQLKKVDGTILLGDSRSVTNTFENKITRVITSPPYYGMSTYEQDQWLRNWFLGGSSQVDYTNQAQLKHGSESVFVNDLAKVWANTAPKCTPDAKLIIRFGALPSKSKKTPRELIKESLALADCGWEISAIRSAGEPKSANRQANQFKGTTGNYVEEIDVYATLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGJ6</accession>
    <name>D7VGJ6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, group 1 family protein</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996615.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10115"/>
    <dbReference type="EnsemblBacteria" id="EFK59198">
        <property type="protein sequence ID" value="EFK59198"/>
        <property type="gene ID" value="HMPREF0766_10115"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_0_10"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="392" mass="45224" checksum="DB6F65114DE6ADF8" modified="2010-10-05" version="1">MIKVAFFAEMMIEDFDGASRTMFQLINRIDSTKFEFLFIYGNGPEQIDDHLSLRIPYFHIPFNRNYTMAVPAIAKKMLKQQLKEFDPDVIHIATPSMLGNFALKYAEKNNIPTLTIYHTHFISYIDYYLKNTPFLIKPTKKEFIKQTVRFYNKCTKVYVPSVSISKELKHLGIQPDKLTLWQRGIDTKLFSPEKKDNNYLRKVTKNKKQNILFASRLEWEKNLVTLIDIYHKCKERGIECNFIIAGDGTAKSACMEQMPDAFFLGKLSHKELAICYASSTLFLFPSITETYGNVVIEAMASGLPCIISNDGGSADFIIDGENGFKCNAEQANDYVDKIELMLSDKNLRKKFKKAGLKYSKQHNWQHLSEIYFRDISDFADMTISSQTAYQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGU6</accession>
    <name>D7VGU6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, group 2 family protein</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10215"/>
    <dbReference type="EnsemblBacteria" id="EFK59298">
        <property type="protein sequence ID" value="EFK59298"/>
        <property type="gene ID" value="HMPREF0766_10215"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055604_0_0_10"/>
    <dbReference type="OrthoDB" id="724641at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="356" mass="41786" checksum="8AC24D73DDB5B952" modified="2010-10-05" version="1">MQLYYILFVYTKVSRYQVQSYQQATDQVPVSVIICARNEENNLKTFLPLILEQEYAQFEVVVVNDCSNDDTQWVLQDFERKYAHLKVVEIKEHIQLKHNKKFGVTMGIKAARYTHFVFTDADCQPNSPQWLSEMAGAFTDGKEIILGYSPYFRQGGFLNKLIRFETTHTAMSYLSYALKKDAYMGVGRNMAYTKELFFKGKGFTSHMHIKSGDDDLFVNQNATKQNTRIVIHPDAHMYSVPKDSWKSYYKQKARHSGASVLYKKKHQRMLATQLASGILFYITLISCLALFPEMWYYMAGAYALRLLLQVIVFRGIYKKLAVHDLIWWLPFLDLYYYFYICINGLFNRKKPQRSWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGZ3</accession>
    <name>D7VGZ3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_10262</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997025.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10262"/>
    <dbReference type="EnsemblBacteria" id="EFK59345">
        <property type="protein sequence ID" value="EFK59345"/>
        <property type="gene ID" value="HMPREF0766_10262"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_601056_0_0_10"/>
    <dbReference type="OrthoDB" id="481557at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029467">
        <property type="entry name" value="Cyt_c7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039118">
        <property type="entry name" value="QrcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39425">
        <property type="entry name" value="PTHR39425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14522">
        <property type="entry name" value="Cytochrome_C7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106932" evidence="6">
        <location>
            <begin position="32"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="32"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="424" mass="46836" checksum="CC4EF7A480A5EA25" modified="2010-10-05" version="1">MRNISSVLGRLAKSISVSLVLLFAVTTVSHAQDAKEGEAIFKSKCTSCHAINRKLVGPALKDITKTKDQEWLIKWVRNSQALIASGDPDAIAIFEEYNKSVMTAFTDLSDDQIKSVLAYIDAESAKADNPEKGGDKGGAAVENTGASNWSILGMVGIILLALVVIVLLNRVSKTLEKVIAKNQIAEDANLGTGTDSRYLAFAKSFVKNKKLVFFAVLMIVAVLSVAGWKTMWNIGVHEGYKPVQPIKFSHQLHAGVNKIECQYCHGGAFKSKNASIPSANVCMNCHNTVTASEHYDGEISPEIAKIYKALDYNPDTRQYGDNPSPIQWIRIHNLPDFAYFNHSQHVVVAGVECQTCHGPIQDMEEVYQYSQLTMKWCVDCHRKTEVNTDNKYYDQLIEAHEKLKKGEKMTAAMIGGLECGKCHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH08</accession>
    <name>D7VH08_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_10277</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997070.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10277"/>
    <dbReference type="EnsemblBacteria" id="EFK59360">
        <property type="protein sequence ID" value="EFK59360"/>
        <property type="gene ID" value="HMPREF0766_10277"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_2_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="106"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="464"/>
            <end position="1114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1117" mass="122412" checksum="A56D31483F662BFA" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH66</accession>
    <name>D7VH66_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CcmB protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ccmb</name>
        <name evidence="7" type="ORF">HMPREF0766_10335</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CcmB/CycW/HelB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997192.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10335"/>
    <dbReference type="EnsemblBacteria" id="EFK59418">
        <property type="protein sequence ID" value="EFK59418"/>
        <property type="gene ID" value="HMPREF0766_10335"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079069_0_1_10"/>
    <dbReference type="OrthoDB" id="1886257at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003544">
        <property type="entry name" value="Cyt_c_biogenesis_CcmB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03379">
        <property type="entry name" value="CcmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="219" mass="24614" checksum="D36B62A9DD8B738F" modified="2010-10-05" version="1">MNLFQQVKTLVYKDVLLEWRSKYAINGILLYVVSTVFVCYQAFTAVDSIVWNALFWIIMLFASINAISRSFVQESTNRQLYYYSIVDAKAIILSKIIYNTLVMILLSAIAFSVYSIIFRNPLADPLLYFISVILGSISFASVFTMVSGISSKAGNNSTLMAILSFPVIIPLLLVLIRLSKNAMDGLERSGSLDHIIVLLAINVITVTISLLLFPYLWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH68</accession>
    <name>D7VH68_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997197.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10337"/>
    <dbReference type="EnsemblBacteria" id="EFK59420">
        <property type="protein sequence ID" value="EFK59420"/>
        <property type="gene ID" value="HMPREF0766_10337"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50339SI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186748_2_0_10"/>
    <dbReference type="OrthoDB" id="2102952at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106894" evidence="2">
        <location>
            <begin position="21"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="70" mass="7843" checksum="CA07502055E248D8" modified="2010-10-05" version="1">MKQTILSIFFMLCTSLYASAQGEIEMATGLRSSGKIWVVVLVLLLIFLGVAAYLFTLDKRISKLEKNTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHH6</accession>
    <name>D7VHH6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rplR</name>
        <name evidence="9" type="ORF">HMPREF0766_10445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997473.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10445"/>
    <dbReference type="EnsemblBacteria" id="EFK59528">
        <property type="protein sequence ID" value="EFK59528"/>
        <property type="gene ID" value="HMPREF0766_10445"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098841_0_1_10"/>
    <dbReference type="OrthoDB" id="1963491at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="117" mass="12499" checksum="5F4A7536A88CE02C" modified="2010-10-05" version="1">MAGHKSSRRERIKKGIRKHLAGSAERPRLSVFRSNKGIYAQIIDDVAGVTLVSASSASKDFAASGNKVDQSKAVGKLVAEKAIAAGINKVVFDRNGYLYHGRIKSLAEGAREGGLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHJ3</accession>
    <name>D7VHJ3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase, family 88</fullName>
            <ecNumber evidence="3">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997501.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10462"/>
    <dbReference type="EnsemblBacteria" id="EFK59545">
        <property type="protein sequence ID" value="EFK59545"/>
        <property type="gene ID" value="HMPREF0766_10462"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027158_0_0_10"/>
    <dbReference type="OrthoDB" id="859760at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610905-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610905-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="414" mass="47033" checksum="03DE85A609200D29" modified="2010-10-05" version="1">MNVKSQALALVFLSLTVISPSFGQKKSALRLSSSFIEQNLKDAAKQIKVLANQTPEDKFPKTFENGKEVFSGSSWWCSGFYPGTLLYLYEGTGDKSLLNYAEEKLKFLEKEKNNKGTHDLGFMLYCSFGNALRLTGDSSDYKEVLVTGANSLSSRYNPTTKTIRSWDHKPWHYPVIIDNMMNLEFLTQASRITGDPRYYNIAVTHANTTLKNHFRKDYSSYHVIDYDKETGKVIAKKTHQGAFDESAWSRGQGWALYGYTMMYRETKDKKYLNQARNVAKYILTNPNLPADLIPYWDFDKDKIPADSKMYKNKDLRDVSAAALYTSALLELAQYTKGKESAGYMEKAEKILENLSSAPYKSAYGETGGYILQHSVGAIPLNSEVDVPLTYADYYYVEALVRYQRLLKGDPVIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHQ3</accession>
    <name>D7VHQ3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heme oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997627.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10522"/>
    <dbReference type="EnsemblBacteria" id="EFK59605">
        <property type="protein sequence ID" value="EFK59605"/>
        <property type="gene ID" value="HMPREF0766_10522"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085041_0_0_10"/>
    <dbReference type="OrthoDB" id="1608763at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="186" mass="20627" checksum="98E70B1CB6B0CB97" modified="2010-10-05" version="1">MLNEQIKEATKQGHQELEKTVVYKLKAIENNADYADVLKHFYVFFSGIEQQIDHLLPESLKPYYAVRRNASHIAQDIEALGGSLTELPSVVLPSLHNATQAIGALYVLEGSIMGGPYIVKMLQQRGIETGFNFFNGYGEQSHQNWAKFTGIINAEVTEEAAIEEAITAAQQTFSSFGQTFNANILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHQ5</accession>
    <name>D7VHQ5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997633.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10524"/>
    <dbReference type="EnsemblBacteria" id="EFK59607">
        <property type="protein sequence ID" value="EFK59607"/>
        <property type="gene ID" value="HMPREF0766_10524"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030QFQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064442_0_0_10"/>
    <dbReference type="OrthoDB" id="1117867at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035163">
        <property type="entry name" value="Pom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17251">
        <property type="entry name" value="Pom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pom" evidence="1">
        <location>
            <begin position="167"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="299" mass="33256" checksum="1FFAAFD17409D001" modified="2010-10-05" version="1">MVSKAIKSLYYVLLLLFSLTVTRTVVSAQNNIDISVYPKVDLINSNWSIAGNMEGKNPNILSELTWKDNVAWGAGGRFSVILHPRIKLSLQAEHSFIVSGTVRDVDYSGDNRTLVDRDMTYDSGEGNMSFATLQLNYLLWRGGIDVEGYVFPQYQYTSLTMIDPTLDLRSTYKSKLLGGGIGLKLGKVINPKWKMSLSPQFALNKYTAVANWNLREEFAHPVSFKHKIGAPQWSGVFDVTYSPSSKLYFLASARYNSLLNAKNGTDQLFYSNGESTHTRLNEVGSSVATFSLGAGILLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI00</accession>
    <name>D7VI00_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5008 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997871.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10619"/>
    <dbReference type="EnsemblBacteria" id="EFK59702">
        <property type="protein sequence ID" value="EFK59702"/>
        <property type="gene ID" value="HMPREF0766_10619"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_507966_0_0_10"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013431">
        <property type="entry name" value="Delta_60_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032175">
        <property type="entry name" value="DUF5008"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16400">
        <property type="entry name" value="DUF5008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17164">
        <property type="entry name" value="DUF5122"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5008" evidence="1">
        <location>
            <begin position="23"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="536" mass="57945" checksum="92C97CACBA01440B" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI11</accession>
    <name>D7VI11_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997892.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10630"/>
    <dbReference type="EnsemblBacteria" id="EFK59713">
        <property type="protein sequence ID" value="EFK59713"/>
        <property type="gene ID" value="HMPREF0766_10630"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_11_0_10"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="438" mass="49709" checksum="2ACC20718C4E8BF7" modified="2010-10-05" version="1">MHYRYIVSVLYFLLGSGFAALGQVCNLQSCISQALQHNLAVQNSEIKEQRSSIAYTRSWQERLPTLNARLGHGINEGKSIDPSTNQFISKRFTSGNQELTTSMVLFDGLGMLYDIRQQSKRWAADQKDQEGALIALKLDVILAYIQVLTAKDILQQAEVNIETTRAQLQRSETLHKQGAIAPGDYFDIKGQYAAESSSINGLKKTLFDRRVALSGLMNIAERELGELAPLEEQTNDIDVWTADAEQLYQEAQDKLPDFQSLQLKADAAEYAVKYAKSAYYPRLTFGAGLNSQYAGTSSDSYLRQIDNNLGKYIAFGLNIPIFNGFKVRNQVKLARLDQRSQQVENDQKRLELRQNTSRAVFEYKQSYENIALLKSQVTDYKESFRIAQVRFDEGDINSVTYIIAKNKYEQSLSQLTVLQYQAILQQYTLDYYQGKLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI24</accession>
    <name>D7VI24_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10643</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997917.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10643"/>
    <dbReference type="EnsemblBacteria" id="EFK59726">
        <property type="protein sequence ID" value="EFK59726"/>
        <property type="gene ID" value="HMPREF0766_10643"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035902_0_0_10"/>
    <dbReference type="OrthoDB" id="405111at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="519"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="586" mass="67898" checksum="8EFA24E326CD52F0" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI79</accession>
    <name>D7VI79_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998027.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10698"/>
    <dbReference type="EnsemblBacteria" id="EFK59781">
        <property type="protein sequence ID" value="EFK59781"/>
        <property type="gene ID" value="HMPREF0766_10698"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032X33">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058228_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="398" mass="46203" checksum="39E7BCB3264084A6" modified="2010-10-05" version="1">MMPINIINILLFLISPFLALPTILVGIIKKSKFALTLFIVFIGILSYLYIPNYSDDKSRYIEIYEDFKSWNYIPFILYNLSNSQDFILQLLFKIASDIGIKVQIVFFTVTIIAVGLLFNIWSEIVLFLKLNRKEFLISLILVVTSISFLDLFSGTRFMLAASVTLYAYFQGFFLNKKWIPILLLLLSINIHFGLLVFAFAYFFIKFIIHKHYLIKAAFLFSFLFLLLPKDFLISIFSSIGFGGALASKSDAYIKADKDFVTQGIREGGFGGMMIYLVQNVWIYAMYIYLLFKIKTKQQYHLIAFLLIAVLNVFYSIPTIYLRYSLFIKMFFVIILILDMQASKVKKAPLFFIGFFICVLITQIIVTRYNIEKSYMDGDSFLFFDILFKKPMSSGDLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIH9</accession>
    <name>D7VIH9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="2">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">typA</name>
        <name evidence="2" type="synonym">bipA</name>
        <name evidence="4" type="ORF">HMPREF0766_10798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998222.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10798"/>
    <dbReference type="EnsemblBacteria" id="EFK59881">
        <property type="protein sequence ID" value="EFK59881"/>
        <property type="gene ID" value="HMPREF0766_10798"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017016_4_0_10"/>
    <dbReference type="OrthoDB" id="143460at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="2"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="601" mass="67383" checksum="3B2D2BCA0163E23B" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ06</accession>
    <name>D7VJ06_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TrkA N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002083.1">
        <property type="nucleotide sequence ID" value="NZ_GL379779.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10975"/>
    <dbReference type="EnsemblBacteria" id="EFK59141">
        <property type="protein sequence ID" value="EFK59141"/>
        <property type="gene ID" value="HMPREF0766_10975"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_5_10"/>
    <dbReference type="OrthoDB" id="1616572at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="292" mass="31369" checksum="DA715ECEFA76F10A" modified="2010-10-05" version="1">MKITITGSLGNIGRFLTEKLLQSGHHVTVVSHSEDRKPEIERLGADAAIGSISDVVFLRNAFKDADAVFAMTPPNMGGIDIISNTVEAGKAMAKAIKESAVSRVVMLSSIGADLPDGNGPIAALHHIEKAYAELEGVAVTFLRAGYFFTNFYNDILLIKTAGITGSNYPSSTSIPLVHPFDIAMAAAERLEQPFTGKNIQYVISDFRTARDVADVLGNEIGQPELPWIEFTDEEAFQGMMQAGVPGEIAGLYVEMGAGIRAGKIQTDFKNVGAPVTGQVKLEDFAKEFADRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ09</accession>
    <name>D7VJ09_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002089.1">
        <property type="nucleotide sequence ID" value="NZ_GL379779.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10978"/>
    <dbReference type="EnsemblBacteria" id="EFK59144">
        <property type="protein sequence ID" value="EFK59144"/>
        <property type="gene ID" value="HMPREF0766_10978"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3831">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_521512_0_0_10"/>
    <dbReference type="OrthoDB" id="397625at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="536" mass="63039" checksum="EC684FBED89E8A78" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJP2</accession>
    <name>D7VJP2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DinB_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000782.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11211"/>
    <dbReference type="EnsemblBacteria" id="EFK59095">
        <property type="protein sequence ID" value="EFK59095"/>
        <property type="gene ID" value="HMPREF0766_11211"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125425_0_0_10"/>
    <dbReference type="OrthoDB" id="1717097at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="157" mass="17969" checksum="E0354310259900DB" modified="2010-10-05" version="1">MIAHTFHYIIQTRKLFLALIDSLTTEELNVIPQGFNNNIIWNFGHIVVSTQSLCYVRTGILADASSIAYNEDYKKDTKPTRPVSKEEIDELKLYALETISKLEKDYHNGVFSSIQPFSTSTYGTEMSTIEEVLTVTLAHDNLHYGYAMAQRRMIKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJP6</accession>
    <name>D7VJP6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_11215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000796.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11215"/>
    <dbReference type="EnsemblBacteria" id="EFK59099">
        <property type="protein sequence ID" value="EFK59099"/>
        <property type="gene ID" value="HMPREF0766_11215"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_45_0_10"/>
    <dbReference type="OrthoDB" id="870493at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="261"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="293"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="488" mass="55671" checksum="08061C0AB8A45981" modified="2010-10-05" version="1">MMSNPVVHIANLTVQYPNQSVLQSLNWQIEQGENWLIGGKSGSGKTTLALAIADQVQFSGNVDIHFDSTSPLPSKTLYVSNWYQFTNLEGDRNFYYQQRYNKHQGNDTLTVYAEFMHYGKQENLNPEDLEVYLRKFGFQNQKNTQLIELSSGEHKKLQLIKALWLQPQILIIDQPYTGLDKQSRHELNNVFNQLASEGVTLILISNDEEHPDCINRFAEIQEGQLNIRNSASEISREAERISKPLPGFLQQPPKVTSDIMVSMHNVTIRYDEKEVLKNIDWEVRAGEKWLLQGHNGSGKSTLLSLINGDHPQAYANDITLFGKKRGSGESIWEIKEHLGIISPEMHWYFDATAKVWQSIASGFFDSVGLFRDLSFEKQRKVDEILAFFDLKEYKNQLLSTLPLGKQRLVLLARTIIKNPELLILDEPCQGLDYEQTKQFNAIVDELCSHGNTLIYVGHFETQLPSCIDNRIILENGKVKAVETALENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJT1</accession>
    <name>D7VJT1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000902.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11250"/>
    <dbReference type="EnsemblBacteria" id="EFK59134">
        <property type="protein sequence ID" value="EFK59134"/>
        <property type="gene ID" value="HMPREF0766_11250"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012729_2_0_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106961" evidence="1">
        <location>
            <begin position="20"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="888" mass="102092" checksum="675E1DCA373E926C" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKJ6</accession>
    <name>D7VKJ6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11515"/>
    <dbReference type="EnsemblBacteria" id="EFK58798">
        <property type="protein sequence ID" value="EFK58798"/>
        <property type="gene ID" value="HMPREF0766_11515"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503186P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141661_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106986" evidence="1">
        <location>
            <begin position="33"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="165" mass="18375" checksum="1C670343B3A0ADA3" modified="2010-10-05" version="1">MYKLILKNMKNIISKSLLMLPVLLIMSCGAKKDPAEYNNELMTVINGGEKNITEMNSAMQAGDFDKAGKVQQEWSTALDKDIKKVEEIGDFNGDANLQTAILTGLKGYKKIVAEDYPKLIDLRKNKKEDPATEQQLLNNINNALEVMANGVNEASGKFERDHAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKK6</accession>
    <name>D7VKK6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="3">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">idi</name>
        <name evidence="8" type="ORF">HMPREF0766_11525</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999349.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11525"/>
    <dbReference type="EnsemblBacteria" id="EFK58808">
        <property type="protein sequence ID" value="EFK58808"/>
        <property type="gene ID" value="HMPREF0766_11525"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060552_2_1_10"/>
    <dbReference type="OrthoDB" id="1345242at2"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00202">
        <property type="entry name" value="Idi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="32"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR018427-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="177" mass="20676" checksum="F48BE9B53716FE38" modified="2010-10-05" version="1">MITPMEQELITVNNNDEETGTISKSEAHRLGILHRAFSVLIFDTEGKMLLQKRADQKYHSGGLWTNACCSHPRPNETTIDAAHRRLQEELGFNCPLTYLYKFQYFANLDNDMIEHEMDHIFMGIYDGTITPDPYEVSSYTYLTLDDISSRIQQEPQSFTIWFKIIFQHYMDHLNTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKR4</accession>
    <name>D7VKR4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="16">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">murB</name>
        <name evidence="18" type="ORF">HMPREF0766_11583</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the MurB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="16"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999460.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11583"/>
    <dbReference type="EnsemblBacteria" id="EFK58866">
        <property type="protein sequence ID" value="EFK58866"/>
        <property type="gene ID" value="HMPREF0766_11583"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035304_0_0_10"/>
    <dbReference type="OrthoDB" id="841869at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 16" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 16" id="KW-0133">Cell shape</keyword>
    <keyword evidence="15 16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0274">FAD</keyword>
    <keyword evidence="8 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 16" id="KW-0521">NADP</keyword>
    <keyword evidence="13 16 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 16" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="17">
        <location>
            <begin position="32"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFK58866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="351" mass="39895" checksum="A5FBB3C5E119AEA4" modified="2010-10-05" version="1">MFFFEHLKTRVKKMNNLIQSDISLKSYNTFGVDVLARRFVQIENRQQLLQIYNEGYFNDNFLILGGGSNMLFTKDYEGLLIKIALKGIHNTIQQNFVFVTAQGGEIWNDLVWHCVSNNFPGLENMALIPGTVGASPVQNIGAYGSELMHIFYSCVAFDTRTGQFVTFAKEDCEFSYRDSVFKSKHKNRYIIVEVTYKLNLDAPLNTSYGAIEKELSNRQISNPTIKDIAEVVSYIRVEKLPDPSTVGNAGSFFKNPIISKNILDRLIVDFPEIVYYNVDEEHVKLAAGWLIEQCGWKGKKLGRAGVWHNQALVLINADNASGEEIYNLSSTILNDVYQKFGIRLEREVNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL03</accession>
    <name>D7VL03_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999684.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11672"/>
    <dbReference type="EnsemblBacteria" id="EFK58276">
        <property type="protein sequence ID" value="EFK58276"/>
        <property type="gene ID" value="HMPREF0766_11672"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZAIK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1440239_0_0_10"/>
    <dbReference type="OrthoDB" id="1169020at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="189" mass="23052" checksum="82F1D65311203ECF" modified="2010-10-05" version="1">MHEIEPFYNWRDYYIASEDELSPFYGTIYNEFEYDKQIYNFLLHPQWDHFGSSTLYLKVLYVDYDKGYTIIEFIGEWNDAIYNDIMLLKRELIDLMIDEGINKFILIGENVLNFHASDDLYYEEWFQNIEDGWIAGLNFRSHVIEEFKSHNIDYYINFGGIFDQMPWRTLKPKQLYHHVNEQLTRRLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL33</accession>
    <name>D7VL33_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999744.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11702"/>
    <dbReference type="EnsemblBacteria" id="EFK58306">
        <property type="protein sequence ID" value="EFK58306"/>
        <property type="gene ID" value="HMPREF0766_11702"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_18_6_10"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="155" mass="17445" checksum="5984D3791EB30154" modified="2010-10-05" version="1">MSQDNTIDYFMKTGWQTVANKYNTIASQYGFTQAAGYILINIHKEGTPVSQIANLTGVKTTSLSRVLNNLETLGFIYREASDVDKRSVKVYLTELGKEKRKIAKDVVRSFNQYLEANISARERAQLIKTLIKINELAKDYQEEVQSNAADNIAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL61</accession>
    <name>D7VL61_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OMP_b-brl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999795.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11730"/>
    <dbReference type="EnsemblBacteria" id="EFK58334">
        <property type="protein sequence ID" value="EFK58334"/>
        <property type="gene ID" value="HMPREF0766_11730"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100971_1_0_10"/>
    <dbReference type="OrthoDB" id="2018542at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMP_b-brl" evidence="1">
        <location>
            <begin position="23"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="209" mass="22618" checksum="D184949BBF0ABE90" modified="2010-10-05" version="1">MLLRFEVVKQILYAMKKLLFSIIAMLLIGATVAQAQGFKGKWFIMGEAGYSTQSDGNIQHYSVLPVVGTFVAPTTAIGLGVGYLGQKDKTVPDVVGKEEAFIVQPLARKYWGITDNFLIFGQAAVPLTFGKNSIDANGVKTDSKFTGYGVQLSPGIDYFMSSHFSIEASFGLVGWSAVKPKDGETANDFNIGVNSGFQNGVKFGLKYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLA1</accession>
    <name>D7VLA1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Low molecular weight phosphotyrosine protein phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999923.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11770"/>
    <dbReference type="EnsemblBacteria" id="EFK58374">
        <property type="protein sequence ID" value="EFK58374"/>
        <property type="gene ID" value="HMPREF0766_11770"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071415_2_1_10"/>
    <dbReference type="OrthoDB" id="2062716at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="3">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="144" mass="16433" checksum="0CABDC645A49E32F" modified="2010-10-05" version="1">MKILMVCLGNICRSPLAHGVLQHLVDEHGLGWEIDSAGTGDWHIGQAPDHRSIAVAAKYGIDISKQKAQHFNPTLFDRYDYILVMDNQNYKDVIAQTTSVDEREKVKLFIPDNAVPDPYFDAKMFDPVYKMIEKRCAELINELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLA6</accession>
    <name>D7VLA6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="8">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">gltX</name>
        <name evidence="12" type="ORF">HMPREF0766_11775</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999938.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11775"/>
    <dbReference type="EnsemblBacteria" id="EFK58379">
        <property type="protein sequence ID" value="EFK58379"/>
        <property type="gene ID" value="HMPREF0766_11775"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015768_6_3_10"/>
    <dbReference type="OrthoDB" id="1409413at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="10">
        <location>
            <begin position="7"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="11">
        <location>
            <begin position="371"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="260"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK58379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="508" mass="58328" checksum="0BCC64E5756ED659" modified="2010-10-05" version="1">MSSQKRVRVRFAPSPTGGLHLGGVRTALFNYLFARQHQGEFILRIEDTDQTRFVPGAEEYINECLAWCGIVPDESPSKEGAYGPYRQSERKPSYRQYAEQLVEKGFAYYAFDTAEELDEQRKIQPNFRYSHENRMNLRNSLSLPAEVTQQLLAEGHSHTIRIKMPQDETVSFEDMIRGRVSFETGLVDDKVLLKADGMPTYHLAVVVDDKAMEISHIFRGEEWLPSAPVHILLWEYLGWADEMPQWAHLPLILKPDGNGKLSKRDGDRLGFPVYAMNWTDPKTGDLTKGFRELGFLPEAFVNMLGVLGWNDGTEQELFSLAELIEKFSVSRVSKAGAKFDFEKAKWFNHEWIKRTDDVTLLPKIKENIEQHGVDTSTQSETYMLNVLGAVKERLTYVEDFWTQASFFFVTPEQYDVEAVKPKWNEQKTAFFQEIINDFELQSDWTAAVLEPLFKEKITSSGLKMGELMMPYRIMLVGGKFGPDVFQITELLGKEEVIRRIGKALPLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLA8</accession>
    <name>D7VLA8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DinB_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999944.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11777"/>
    <dbReference type="EnsemblBacteria" id="EFK58381">
        <property type="protein sequence ID" value="EFK58381"/>
        <property type="gene ID" value="HMPREF0766_11777"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105789_2_0_10"/>
    <dbReference type="OrthoDB" id="1759689at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="29"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="173" mass="20417" checksum="856E0B709AD080E2" modified="2010-10-05" version="1">MNPLKSDEYPAIYADYIETIVGDVMEVLEDQLSTFPAFISSIPKEKELYKYAEDKWTIKEVLCHILDAERVMSYRALRFARNDMTSLPAFEQEEFVQNGRHNERTLESIIEEFNYLRRSNLSLFHTFNETELSRKGMASDRLISVRAFVYIVAGHLNHHKFIIQERYLNPDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLJ2</accession>
    <name>D7VLJ2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000169.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11862"/>
    <dbReference type="EnsemblBacteria" id="EFK58465">
        <property type="protein sequence ID" value="EFK58465"/>
        <property type="gene ID" value="HMPREF0766_11862"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3530">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176025_0_0_10"/>
    <dbReference type="OrthoDB" id="1886238at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024530">
        <property type="entry name" value="QSregVF_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40613">
        <property type="entry name" value="PTHR40613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12843">
        <property type="entry name" value="QSregVF_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="71" mass="8190" checksum="3F1DBB804F9F90B8" modified="2010-10-05" version="1">MFNPEILTELANTPMPYGKYKGVLLCRLPESYIVWYRQKGFPKGKLGNQLATLYEIKLNGLEYLLAPLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLQ3</accession>
    <name>D7VLQ3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">OmpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">oprF</name>
        <name evidence="12" type="ORF">HMPREF0766_11923</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000302.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11923"/>
    <dbReference type="EnsemblBacteria" id="EFK58526">
        <property type="protein sequence ID" value="EFK58526"/>
        <property type="gene ID" value="HMPREF0766_11923"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047401_0_0_10"/>
    <dbReference type="OrthoDB" id="583204at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103647">
        <property type="entry name" value="SSF103647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0626">Porin</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107026" evidence="10">
        <location>
            <begin position="28"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="11">
        <location>
            <begin position="348"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK58526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="460" mass="49674" checksum="BE47710B61810300" modified="2010-10-05" version="1">MNYSTIKKTAIAASLVAALGYAEVAQAQQPTVFGGRSQYRTWSIGVQGGITTPNVLIGGSNAFGQKVGLFQNKVGEYYGLTVRKQFSHLFGLELEGNRGKIKTYNHDVSGPVAETANGARSAQVDVNWAASLNGVFQLGTIDFLRRENAVNFYAKVGLGVMASNPIQYANNDFTGAEVYNNKGKWGEEIFGDREKVGDRDNKLGAFVPVGVGVKFKLSEVVALNLGYTMNFTDDNLLYGPARTDYKGKFSNVYGGLEFTLGSRDKQSLTFTNPVATMYDELKDPSLKNEVEALKQRVSTLEGTVDQLGKDSDGDGVSDKFDKCPNTPAGTVVDGSGCPIKFPEPVVNNYTASTGQYGSIQFEFDSSVLKTESYSTLDRLAKELRDNNSSVTLDGYASAEGTEAYNMTLSKDRANAVKQYLVNAGVTAAKVTANGYGEANPVASNATEEGRIQNRRVEIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLZ8</accession>
    <name>D7VLZ8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001153.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11995"/>
    <dbReference type="EnsemblBacteria" id="EFK58003">
        <property type="protein sequence ID" value="EFK58003"/>
        <property type="gene ID" value="HMPREF0766_11995"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108040_0_0_10"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107402" evidence="2">
        <location>
            <begin position="32"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="224" mass="24552" checksum="9F0C031D9356215E" modified="2010-10-05" version="1">MKLNFLNITLKNAKMGLATLALAFFALSASAQQKEQEHSNPNVRLGQKALLDGDFKSAATHLEKALPKEGSDPNVLYMLGYSQFHNGDFKKASDTFGKVVALDAKNGTAYYYKAKASNNLAVQTESKLSSASREQLLKTAIDDFSKAIAINSSDAKLYQNRAIAYRDLGILVGTSGAANYNKTAATDAYNKAISDYQKLLSFDSSRKDIQREVKKATVYRDNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM04</accession>
    <name>D7VM04_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, group 2 family protein</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001170.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12001"/>
    <dbReference type="EnsemblBacteria" id="EFK58009">
        <property type="protein sequence ID" value="EFK58009"/>
        <property type="gene ID" value="HMPREF0766_12001"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023845_4_0_10"/>
    <dbReference type="OrthoDB" id="957193at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="343" mass="40159" checksum="90D29AD97EE3DF46" modified="2010-10-05" version="1">MKNYPRVAVVILNWNGVFFLEKFLPSVYNSAYPNIEFVIGDNNSTDNSIEFVQNYYPHITIIQNDTNYGFAGGYNKVLQKVEADYYVLLNSDVEVTENWIAPVIDMLEADPDMVAAQPKILAYHDKQKFEHAGGAGGFIDAFGYPFCRGRIMDHLEEDHGQYNDVKEVFWASGAAFFIKSEAWREAEGFDTDFFAHMEEIDLCWRLKKMDYKIGYCPQSVVYHVGGGTLNTSNPKKTYLNFRNNLLMLQKNLPFWTAVWVIFARLWLDLAAIFKFLTEKKFKDAWAISRAHQYFFLNIFKTAEKRKEQIRFENKKGKYKGCVIWEYFMNKRRKFSDLPVENFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM08</accession>
    <name>D7VM08_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001183.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12005"/>
    <dbReference type="EnsemblBacteria" id="EFK58013">
        <property type="protein sequence ID" value="EFK58013"/>
        <property type="gene ID" value="HMPREF0766_12005"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039603_0_0_10"/>
    <dbReference type="OrthoDB" id="949367at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="375"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="450" mass="51232" checksum="1016DD8C0DEC1E05" modified="2010-10-05" version="1">MRYLIIILFLCNVFPIHAQGHFEFIKDEDKAVIPFQFVRNLALVPIKINGVDLIFLVDTGVKETILFSLEDNTLSFKNTKKLKFNGLGENEGIEAIQATGNTVEVGGELIDTAHTVYVILNSDFNFSAYVGVPINGILGSHFFKDHPVEVDFVKHKLTVYRDSEQIERKVRKYERLDIELENSRPYIDTWLSLQQEGIKAKMLVDMGNSDAIMVFPSRVPGFRLNEPNIEEFIGRGFSGDIHGRMSRIHQFQMGKFNFRTPTSSFPDSIAVRSAKLVKDRVGSVGNELLMRFNIIFDYTSQAIYIRKNKFYNKPFLVDMSGLDVKHDGMIWVQDWVKVNIPSEVTNDQLTSTKPVYEASTGALQYKFVLKPSYSVVSVRKGSPAEHAGLKKGDMLISINRRMTGMMSLDQIQHSLSEDEGKKINMVIRRNDQDVKVSFRLKDPIPYVEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM25</accession>
    <name>D7VM25_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001231.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12022"/>
    <dbReference type="EnsemblBacteria" id="EFK58030">
        <property type="protein sequence ID" value="EFK58030"/>
        <property type="gene ID" value="HMPREF0766_12022"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032TWQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1189303_0_0_10"/>
    <dbReference type="OrthoDB" id="1616734at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107321" evidence="1">
        <location>
            <begin position="17"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="233" mass="26720" checksum="5D2D8618AFA25758" modified="2010-10-05" version="1">MRILILLLLVSLTAQAQKKEIAVGYADTYDKLPSIKFQKSSKEEYDLCRQALRPDSLPLKEANGYMLIPTKQGTVRLQKYNDSAKGDFRGYEYSGYFPGLKMYVVNSIHVAEHIGFSDRILIDSTSGYQYAIVSVGDDAVEIPVPSPDGNYILYYYNYVYEKNSCFIGILNVDKITHPAKRLSEKMSFQTKDWAVEEIRWKDNRTFMVKASVAENTNNQQNINHLYYIAHLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM28</accession>
    <name>D7VM28_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dnaJ2</name>
        <name evidence="2" type="ORF">HMPREF0766_12025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12025"/>
    <dbReference type="EnsemblBacteria" id="EFK58033">
        <property type="protein sequence ID" value="EFK58033"/>
        <property type="gene ID" value="HMPREF0766_12025"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1774657_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025309">
        <property type="entry name" value="KTSC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13619">
        <property type="entry name" value="KTSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="12"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="155" mass="17890" checksum="D6DDD5574F1C61F8" modified="2010-10-05" version="1">MPTFAAMKKIADYRRLLNVDKSADLKILKSTYRAIMKECHPDKFVNDEEGRIAAEIKSKEMIEAYHFLVSICPETLENQLPIYTATIANSGIADFDWKSQVLVITFHDGSQYEYFGVAKNDYIKFINADSPGRFARRHIFHSYPYRNVLKTSEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM84</accession>
    <name>D7VM84_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Succinate dehydrogenase and fumarate reductase iron-sulfur protein</fullName>
            <ecNumber evidence="4">1.3.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">frdB2</name>
        <name evidence="4" type="ORF">HMPREF0766_12081</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.1" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001366.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12081"/>
    <dbReference type="EnsemblBacteria" id="EFK58089">
        <property type="protein sequence ID" value="EFK58089"/>
        <property type="gene ID" value="HMPREF0766_12081"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044838_3_3_10"/>
    <dbReference type="OrthoDB" id="1605514at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="248" mass="27744" checksum="6EAC6A73E6797748" modified="2010-10-05" version="1">MKLHLKIWRQEDRNSKGKLVDYELENLNPHMSFLEMLDTLNEKLIVENDQPVEFDHDCREGICGQCGMMINGIAHGPLENTTTCQLHLRTFKDGETVFIEPFRSHAFPVKKDLKVDRSAFDRIISSGGFVSVNTGQAPDAHAIPVTHQSTEAAFDAAACIGCGACVATCKNGSAALFTSAKIAHMALLPQGREERNERVINMVQQMDQEFFGHCSNTEACEVECPQGISVINIARMNYEYNRALFYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMA3</accession>
    <name>D7VMA3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001400.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12100"/>
    <dbReference type="EnsemblBacteria" id="EFK58108">
        <property type="protein sequence ID" value="EFK58108"/>
        <property type="gene ID" value="HMPREF0766_12100"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plug" evidence="1">
        <location>
            <begin position="124"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1060" mass="118364" checksum="D9D1A0E5CCC8BB02" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMG1</accession>
    <name>D7VMG1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_12158</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001506.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12158"/>
    <dbReference type="EnsemblBacteria" id="EFK58166">
        <property type="protein sequence ID" value="EFK58166"/>
        <property type="gene ID" value="HMPREF0766_12158"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_40_3_10"/>
    <dbReference type="OrthoDB" id="1570162at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="199" mass="22788" checksum="FD501D6457970221" modified="2010-10-05" version="1">MGISERRFREQEQLKQLIVAQSWSIVAEEGWAALSLRKIADAIEYSVPVIYKHFSSKDDLIEYFTKEGFRLLAEQLASAISQDDSAEVKIRHIAEAYWSFAFTHQKHYEIMFGLGIPTCEAIQTVQEKRKTSEILLTVIEEAILQSKRTDTDKYLKMKTFWSIMHGLVAIELLSVNQKSIEPSAILKDAVDGYIKSLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMK0</accession>
    <name>D7VMK0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992633.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12220"/>
    <dbReference type="EnsemblBacteria" id="EFK57147">
        <property type="protein sequence ID" value="EFK57147"/>
        <property type="gene ID" value="HMPREF0766_12220"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7RJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123222_0_0_10"/>
    <dbReference type="OrthoDB" id="1995488at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011630">
        <property type="entry name" value="DUF1599"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07659">
        <property type="entry name" value="DUF1599"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1599" evidence="1">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1599" evidence="1">
        <location>
            <begin position="114"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="181" mass="20901" checksum="77D9B95342B09359" modified="2010-10-05" version="1">MDTIQEYNSVIEHCQNLFIRKTKDYGTAWRIMRLSSITDQIYIKAQRIRTLEVKQVSKVGEGIADEYIGIINYCVIAMLQIELGEDGEENLDPTFVNQKYNEKVEQTRDLMLAKNHDYGEAWRDMRISSLTDLILMKIHRVKQIEDNGGQTIVSEGINANYQDMLNYAVFALIKMGLATQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMM1</accession>
    <name>D7VMM1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="8">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">ileS</name>
        <name evidence="11" type="ORF">HMPREF0766_12241</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992683.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12241"/>
    <dbReference type="EnsemblBacteria" id="EFK57168">
        <property type="protein sequence ID" value="EFK57168"/>
        <property type="gene ID" value="HMPREF0766_12241"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_1_1_10"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="31"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="10">
        <location>
            <begin position="788"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="701"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="704"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK57168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1151" mass="131535" checksum="599659E3C2F5FBE8" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMP8</accession>
    <name>D7VMP8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase, PfkB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992725.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12268"/>
    <dbReference type="EnsemblBacteria" id="EFK57195">
        <property type="protein sequence ID" value="EFK57195"/>
        <property type="gene ID" value="HMPREF0766_12268"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_0_1_10"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="14"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="350" mass="38527" checksum="929BEF30A215C52B" modified="2010-10-05" version="1">MIDQDFQGAGKGKVLSFGELLLRICPDGNGMWLAENKLPFYIGGAELNVATALALWDVPSSYLTAVPDHAIAHDIVNSVSGIGVDMDPVLFSGDRFGIYYLPKGKDLKNASVIYDRANSSYAELKTGDIDWNNAFKGVSWFHFSAICPAISQDIADICLQAVKAASEKGITVSLDLNYRSKLWKYGKEPLEILPELAPYCTLIMGNVWASNKMLGTTLHNSLTENGEYERDILLEQATETSKEIIAAYPHCKAVANTFRFDYGQGIRYYTTLYTQGELTVSREYISTQILDKVGSGDCFMAGLIYGFYHQLPAKETLAFATAAAYDKLFIPSDATTSSVADVLKMKTENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMW0</accession>
    <name>D7VMW0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992835.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12330"/>
    <dbReference type="EnsemblBacteria" id="EFK57257">
        <property type="protein sequence ID" value="EFK57257"/>
        <property type="gene ID" value="HMPREF0766_12330"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_1_2_10"/>
    <dbReference type="OrthoDB" id="1432684at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="2">
        <location>
            <begin position="72"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="353" mass="38284" checksum="3C8485C81A32CBB3" modified="2010-10-05" version="1">MFYKYRTHKLGILIPLLSILFTACESKPKKEEAAAPAAAGKLPVDVIVAQEQELDQQEIFVGTLLPLREISVVSETAQKITKVAFTDGSHVSQGDVLYTLNDADIRSRLRQVQAELKLALLNKDRMTNLLKTETVQQQEYDEAVTRVNSLEAQQDYLQTELAKTVIRAPFSGKVGITKAYLGAYVSPGTALVNLQDQSSIKINFTLPERYLPLIKNGTPIKFSIGPSEEQYSASITATEPGLDAQGRSLEVQAVTNNSSGKFRAGQSVKVYFSTEQKGTTGVMIPTEALMPGGKGYNAFVIKDGIAKPVPVTISNRTETEAIITSGINSGDSIVVSNMMRIGDGTPVQAVVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMW7</accession>
    <name>D7VMW7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12337"/>
    <dbReference type="EnsemblBacteria" id="EFK57264">
        <property type="protein sequence ID" value="EFK57264"/>
        <property type="gene ID" value="HMPREF0766_12337"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033763">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154640_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020509">
        <property type="entry name" value="Uncharacterised_YnzE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17329">
        <property type="entry name" value="DUF5367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="128" mass="13979" checksum="74511AF13F6699B2" modified="2010-10-05" version="1">MPVLGIGFLIWLLATIAFRVAGQYFFITDSAVVLSILYIIVVPVLGLVTVFTCRKLRLTGLENVVAGVLLVLPGMLIDTFVIQFFGDIFPNMPASNAATFGSWLMWAYTIVLITSIIIGLGRTAKPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN31</accession>
    <name>D7VN31_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12401"/>
    <dbReference type="EnsemblBacteria" id="EFK57328">
        <property type="protein sequence ID" value="EFK57328"/>
        <property type="gene ID" value="HMPREF0766_12401"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1991263_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="125" mass="14885" checksum="3C66621816E13EB5" modified="2010-10-05" version="1">MIHLIYIYFIANAFMTGLAIGYREGLLQCIICVLIGLPYYSIVCLYCFTEALICWLDKKLIIKGWYRLRFTDYFSRMNETTIAIRRAQYFGEAKNLRKANWYDRFFLRQIDKKYGYGITKGDPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN41</accession>
    <name>D7VN41_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phage portal protein, SPP1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992947.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12411"/>
    <dbReference type="EnsemblBacteria" id="EFK57338">
        <property type="protein sequence ID" value="EFK57338"/>
        <property type="gene ID" value="HMPREF0766_12411"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZBX3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044337_0_0_10"/>
    <dbReference type="OrthoDB" id="964293at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021145">
        <property type="entry name" value="Portal_protein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05133">
        <property type="entry name" value="Phage_prot_Gp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="492" mass="53988" checksum="AAF4A4971259DA48" modified="2010-10-05" version="1">MAKEIKVATAAIDPKIIEELGKESAPAYEVKKETDIKEHNIYDEQLRKLKTVVKKVIGPDGKPVMMADGRTPTTTTTYVDPARLPLALQEIIVTRRVAFMNLGKARLYAEPAKGAQEKAFNLLQRLRENNKVGYKESEIAKLLNKELQVAKLWYSKVTDDASHWGGLSKVAVDYKMQILAPSKGDTLLPVFDANGDLTYFGRQYDRRKSLEELAGETSGGDKTVKCFDIYSSDRLLKFEQGGSGGGAEGGWMLVASVDLPYKKLPIIYYSKDIPIWANVQPLIERLETVISNFADTNDYHASPTLVFKGATGAQAQEKGESGKAVLLTGEHADAKYVTWDQSVAAVELEIDTLVNFIYSLTQTPNISFEEMKALGDLSGVAFDRVFIDAHLAASNEIDGGYGELLQRSVNLEKALLASMDTGLTAALQELAVTVEVPRFKLDDLDADVDLAIRAKDGGLISVETAIGMSGLVTNVQEEIKRINKQSDLSIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN85</accession>
    <name>D7VN85_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12455"/>
    <dbReference type="EnsemblBacteria" id="EFK57382">
        <property type="protein sequence ID" value="EFK57382"/>
        <property type="gene ID" value="HMPREF0766_12455"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2556548_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="82" mass="9893" checksum="B4B2D28DFAC2395D" modified="2010-10-05" version="1">MEGYYDKKIRNFATIGRISVNFIWILTLLSILNNFTNWFSEYDDIQEEYVENFKTIFMISLYTCFPMTGIIWLLRTNKSDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNA2</accession>
    <name>D7VNA2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD dependent epimerase/dehydratase family protein</fullName>
            <ecNumber evidence="2">1.1.1.219</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dfrA</name>
        <name evidence="2" type="ORF">HMPREF0766_12472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.219" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993023.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12472"/>
    <dbReference type="EnsemblBacteria" id="EFK57399">
        <property type="protein sequence ID" value="EFK57399"/>
        <property type="gene ID" value="HMPREF0766_12472"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_0_10"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003854">
        <property type="term" value="F:3-beta-hydroxy-delta5-steroid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045552">
        <property type="term" value="F:dihydrokaempferol 4-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3Beta_HSD" evidence="1">
        <location>
            <begin position="8"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="339" mass="37539" checksum="033500700FECA11E" modified="2010-10-05" version="1">MTNSNLVLVSGANGHLGNNLVRLLVKKGFQVRASVRNIRNKESFKDLNCEVVQADISNKSSFVKALQGVHTFYAVGAVFKLWAKDPQKEIYDVNMFGTRNTIEAAAEAGVKRIVYVSSIAALDYTNLPTKESNGYNPDRRDMYYNSKNDGERLAFQLAGEYGIELVSVMPSAMIGSKAFQPLSVSFNILKLVLTKKIPVDTKITLNWVDVKDVAEGCYLAALKGRAGERYILANEKCMTLTDTTKLARELHPELKLKVPGSVPKFVLFIIAGLMELSARLKGEAPIITTKEIAMFSGLQQDFDISKSRNELGFNPKNPESALKEALAYLMDNKALLQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNH1</accession>
    <name>D7VNH1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase, thiamine diphosphate binding domain protein</fullName>
            <ecNumber evidence="2">2.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tktA</name>
        <name evidence="2" type="ORF">HMPREF0766_12541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993116.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12541"/>
    <dbReference type="EnsemblBacteria" id="EFK57468">
        <property type="protein sequence ID" value="EFK57468"/>
        <property type="gene ID" value="HMPREF0766_12541"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_4_1_10"/>
    <dbReference type="OrthoDB" id="1543182at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="1">
        <location>
            <begin position="10"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="282" mass="30592" checksum="655038986DAD1311" modified="2010-10-05" version="1">MSADINKLEQIASQVRRDIVRMVHACQSGHPGGSLGCTDYFVALYFNAMKRNPSFNMDGIGEDLFFLSNGHISPVFYSTLARAGYFEVSELATFRKINSRLQGHPTTHEGLPGIRVASGSLGQGLSVAIGAAQAKKLNKDNNLVYVLMGDGELQEGQVWEAAMYAPHNKIDNLIATVDYNKAQIDGSTDQVLSLGDLRGKWEAFGWDVLEIAKGNDMTAVVAGLEEAKSRTGKGKPVVILMHTEMGNGVDFMMGSHKWHGVAPNDDQLTSALGQLQQTLGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNJ8</accession>
    <name>D7VNJ8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PRTRC system protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993150.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12568"/>
    <dbReference type="EnsemblBacteria" id="EFK57495">
        <property type="protein sequence ID" value="EFK57495"/>
        <property type="gene ID" value="HMPREF0766_12568"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033B33">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199579_0_0_10"/>
    <dbReference type="OrthoDB" id="2035597at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032866">
        <property type="entry name" value="Prok_Ub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022289">
        <property type="entry name" value="PRTRC_protein-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14454">
        <property type="entry name" value="Prok_Ub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03738">
        <property type="entry name" value="PRTRC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="72" mass="8130" checksum="E792095EA6311C38" modified="2010-10-05" version="1">MLLATVLPRIFILKDKGQDIPLTDPEPRWSVEAVMNFYANSYPILTTAKVSAPVIRDDTIQYRFESVMGTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNK3</accession>
    <name>D7VNK3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993155.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12573"/>
    <dbReference type="EnsemblBacteria" id="EFK57500">
        <property type="protein sequence ID" value="EFK57500"/>
        <property type="gene ID" value="HMPREF0766_12573"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3903">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044704_0_0_10"/>
    <dbReference type="OrthoDB" id="1124521at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="500" mass="58633" checksum="BAB663AE615CA396" modified="2010-10-05" version="1">MNRIEYINKITTCAARFVHEVEGFNAIGNYHINIHAENFLVPLLNEVFGLELENLNSTKKKNFPAIDLADFKNRVAFQITSTSSLDKIRTTLETFSKYDLQNEFDVLYLYILTEKKPQYNDAKLKDVIPDSFGFESSDHIIDKDVILQKINAISSTPKIQAISKLYEHEFSDIQIEQRQLKFENGYLNNEPEDISPNMVKISFPKVLYKAELFINEEAILENLNDYLESIGKRKVKKLKPNTLVKKALKQNKVYFEDWILHEKCIYTFRDLSKNNEPLRKIIDAGTITTLDCKDFYEQDEASNKVFKNLLRKSLIQLCYYKGIEFFPPRGIFRFANSRPPKAKQIRWKGKKESTKTVIFEMTNKKEGHIICYRHLAFKASFLNFEIDWYLVINPTWSFTNPGGYRESRFESAYMAGIKRLENNNSVYNYFRFFAYYLSYTDLFVTEYPYLQTSKNEPLSLSPSLDEQKWIPVKIVEETSEFTPTEISLDNELTNSIFSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNN8</accession>
    <name>D7VNN8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993202.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12608"/>
    <dbReference type="EnsemblBacteria" id="EFK57535">
        <property type="protein sequence ID" value="EFK57535"/>
        <property type="gene ID" value="HMPREF0766_12608"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178450_1_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="68" mass="7780" checksum="D9D1E34D45726240" modified="2010-10-05" version="1">MEIKLQSIITCPNCGHKKEETMPTDACQYFYECEKCKHVLKPKQGDCCVYCSYGNVPCPPIQQNKKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNQ3</accession>
    <name>D7VNQ3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_12623</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12623"/>
    <dbReference type="EnsemblBacteria" id="EFK57550">
        <property type="protein sequence ID" value="EFK57550"/>
        <property type="gene ID" value="HMPREF0766_12623"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036805_13_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="239" mass="28005" checksum="0C13217B340BF37F" modified="2010-10-05" version="1">MDAMHYKVKEDHRFVSRAVYNILGIDRNGHKHLLGMYVSENEGANFWLSVLTDLQNRGVEDILIACIDNLKGFSEAIQSVFPDTEVQTCVVHQIRNSLKYVASKDQKEFMNDLKPVYRADTLDLAELRMDELQDKWGEKYPVVIESWRRNWDRLTTYFRYDKSIRKLIYTTNTIEGFHRQVRKVTKTKGAFTSDIALLKLIYLAHNNIKKKWTMPLANWGTTAQKLAIWFPGRMVLDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNT5</accession>
    <name>D7VNT5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Redoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993278.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12655"/>
    <dbReference type="EnsemblBacteria" id="EFK57582">
        <property type="protein sequence ID" value="EFK57582"/>
        <property type="gene ID" value="HMPREF0766_12655"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033806_0_0_10"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="60"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="442" mass="50407" checksum="E5B95A378E6A1E9E" modified="2010-10-05" version="1">MANKLIRNRITIFIACHNPELVTGGRHFLILICFMLFGVGIARPQSREVGTANNQNITALNIGDQIPDALWNTPLQVVNHPQDKKNITLADYKGKLIILDFWSTWCGTCVAALPRLHELEKEFKDDVIILPMTDQKANEIKAFLKKNRVLSRLNLFSVTDDNTYKFHFPYTMLPHEVWISKSGEVQAITHSSDVTKENITSALKGNANSIAQKKDNLTYDDTRPLLLNNNGADGDFFVSRSIITLAIEGIPRSNALPKVNEKDSTFRVLSTNADIRRMYELAFRELLTMPPNRTKLELKEPFSVSEKRFLQDKYCYEWIAPLSVLKHFPQKVQADLNYHFGINGRMEKRNTKCYTIKIIGKTTIIPNKPEDGLQYLSAWVNKTNKDIQHIPVVNDFTDEKIAIPKIAHAIEDVEAVNRQLKPFGIAIVEDERVLDFFVISEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP20</accession>
    <name>D7VP20_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amidohydrolase family protein</fullName>
            <ecNumber evidence="7">3.5.2.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">allB</name>
        <name evidence="7" type="ORF">HMPREF0766_12740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993426.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12740"/>
    <dbReference type="EnsemblBacteria" id="EFK57667">
        <property type="protein sequence ID" value="EFK57667"/>
        <property type="gene ID" value="HMPREF0766_12740"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_1_1_10"/>
    <dbReference type="OrthoDB" id="906155at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="51"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="445" mass="49197" checksum="E21B00638D0E2DB3" modified="2010-10-05" version="1">MSSILIKSAHIVNEGTTTVADVYIRNGRIEKIGSELQVKADKEIDATGLHLLPGLIDDQVHFREPGLTHKADIWHESRAAVAGGTTSFMEMPNTVPNTLTQELLQDKYDIAAKNALANYSFFMGAANDNLEEVLRTDPRKVCGIKVFMGSSTGNMLVDNEKALEGIFANAPTLVATHCEDEATIKANLAIFKEQYGEEGLTIQMHPLIRSEEACYLSSSKAVELAKKNNTRLHILHISTGKETALFRNDIPLEQKHITAEACIHHMWFSDQDYAAKGNFIKWNPAVKTASDRDQIVKALLDGHIDVIATDHAPHTIEEKLQPYHTAPSGGPLVQHALQALLDMVSQGRMTLEQLVQKSAHNTAICFQIEDRGFIREGYWADLVLVDLHKPYTVSKSNILSKCGWSPFEGHTFTSTVEHTIVSGQLAYTGGSLIEYGAGQRLLFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP59</accession>
    <name>D7VP59_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993481.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57706">
        <property type="protein sequence ID" value="EFK57706"/>
        <property type="gene ID" value="HMPREF0766_12779"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033ZBF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146078_0_0_10"/>
    <dbReference type="OrthoDB" id="1891132at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="137" mass="15002" checksum="45FBB7FD54A39B4E" modified="2010-10-05" version="1">MKRILLALLVIGTTIGLSSCTKEYITNSLPGVSYVLAVKQGDWQLQSGTDRYKTTISMPQLDSRYFEDGDVSVAISYDNDKTAYKLIPAVIRNYSYEASYRVGSVEIEATEVGTNPTIVPPGDMLVKIVLTDAEIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP78</accession>
    <name>D7VP78_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993520.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12798"/>
    <dbReference type="EnsemblBacteria" id="EFK57725">
        <property type="protein sequence ID" value="EFK57725"/>
        <property type="gene ID" value="HMPREF0766_12798"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032SC3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096365_0_0_10"/>
    <dbReference type="OrthoDB" id="1167857at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107401" evidence="1">
        <location>
            <begin position="38"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="258" mass="30390" checksum="6EA05C1330CBB0CB" modified="2010-10-05" version="1">MKIPKLISFKKIEKFITMKFKLFLSLFLCLVFSTAFAQHKKFKFIDELCEYEGTYDSKKYTEQQLKDTYNLYYGESWLLSAADHRHRSKPTEQVLTELKTEYQTKRAKLKGFQLVKNPVFISFRDSLVLSMDQEYLAKSALVKALKDPKALLEYKAPDSCAINYTKPLVEGGEALLKAYEVLTKYQMKNNGDPQRLYNIYLENIQSSKKYESAFKEVLIYGWWNCVNHFIPRPTYDARFSENYHKLFIKVDTLDCDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP90</accession>
    <name>D7VP90_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12810"/>
    <dbReference type="EnsemblBacteria" id="EFK57737">
        <property type="protein sequence ID" value="EFK57737"/>
        <property type="gene ID" value="HMPREF0766_12810"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3122798_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="50" mass="5998" checksum="62555933ED3B79C7" modified="2010-10-05" version="1">MAKRRSKPHYRTIKMKITRKQVHDFQALKNHISTPVLKTTHQKKQLKFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPM2</accession>
    <name>D7VPM2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993798.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12942"/>
    <dbReference type="EnsemblBacteria" id="EFK57869">
        <property type="protein sequence ID" value="EFK57869"/>
        <property type="gene ID" value="HMPREF0766_12942"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127592_3_2_10"/>
    <dbReference type="OrthoDB" id="1864858at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="127" mass="14275" checksum="18FA2759EA9A33D9" modified="2010-10-05" version="1">MNSVVYFEIQAQNPEKSAHFYEQIFGWNFIKEDSLPITYYRIETAGIHGGLFQRPADTPPLNCGTNAFTCSMEVNDFDNIASLIIQNGGQVAMPKFAIPGRCWQGYFLDIDHNVFGIFEVNENAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPR4</accession>
    <name>D7VPR4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase, S41 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993864.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12984"/>
    <dbReference type="MEROPS" id="S41.012"/>
    <dbReference type="EnsemblBacteria" id="EFK57911">
        <property type="protein sequence ID" value="EFK57911"/>
        <property type="gene ID" value="HMPREF0766_12984"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031949_0_1_10"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041613">
        <property type="entry name" value="Pept_S41_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18294">
        <property type="entry name" value="Pept_S41_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="99"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="449" mass="50205" checksum="A1C6DA7E39F5C04B" modified="2010-10-05" version="1">MKSLCHLRSAIILSTLAISLFTGCKKEDDPAPAGTHKAVNQWIMAQMKHYYYWNNQLPSGKTDETSPDIYFKSLLVPQDHFSSILQTKNISTYGNTLANTFGFDFIQISQNGNIHNIISQVVPYSQAQQSGLSRGDTITAWNDQFLTPSNVSDLTQKALSRNTLRLTLQSGVTLQLASAYIAQPVVYTHRIIQQQDKTYGYIYLSQFDFSGAYDLIRVAEDFRQKKITELILDMRYNAGGQVSFAAFCSLLLAKVQADDTFLMYQGNASLGLQRLSFAQSLSRQPDGYSFTAEDLRSKSLQLSRIHILSTSYTASAAELLINNLSPYVEIIHIGETTMGKDMASVTLTSPDNINGSAESWHILPLVYKLYNKNNKGDYSEGLIPRYAISDHNSLPLYPFGSEQDPYVAFVLNRTSSSRNTSLQKATVSKEGQLLYRSDTKGYRPIILSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPX5</accession>
    <name>D7VPX5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Toxin-antitoxin system, toxin component, PIN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14335"/>
    <dbReference type="EnsemblBacteria" id="EFK57132">
        <property type="protein sequence ID" value="EFK57132"/>
        <property type="gene ID" value="HMPREF0766_14335"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196707_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="76" mass="8867" checksum="747B57EE5816AAB3" modified="2010-10-05" version="1">MATAYLREKVVGKTSYADCLHIALATICKADYLISWNFKYIVNVDRIRGYNAVNIKNGYKQLEIRSPRDFIKYEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ57</accession>
    <name>D7VQ57_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">nusA</name>
        <name evidence="9" type="ORF">HMPREF0766_13111</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NusA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994057.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13111"/>
    <dbReference type="EnsemblBacteria" id="EFK55908">
        <property type="protein sequence ID" value="EFK55908"/>
        <property type="gene ID" value="HMPREF0766_13111"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029242_2_2_10"/>
    <dbReference type="OrthoDB" id="384865at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="139"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK55908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="412" mass="47168" checksum="A54A14FEDD50C27D" modified="2010-10-05" version="1">MSSNINLIDSFQEFKEFKNIDRPTVISVLEEVFRSMIRKRFGTDENVDVIVNPDNGDLEIWRTRVVVEDEFSEDDDLEIELAEAVKHDADLEVGDDYIEQITLESFGRRAILAARQTLVSKILELEKDEVFKKYKDREGELVIGEVYQIWKKEILVLDDDGNELILPKTEQIPADYFKKGDSIRAVVHKVDMMNNNPKIIISRTAPAFLQRLFELEVPEIFDGLITIKKIVREPGERAKVAVESYDDRIDPVGACVGMKGSRIHGIVRELRNENIDVINFTTNHSLYITRALSPARISSIKIDEDNKTAAVYLKSDQVSLAIGRGGHNIKLAGKLTGYEIDVYRENDEFDEDVDIEEFSDEIEGWVIDELKRVGLDTAKSVLSLTEEELVRRTDLEEDTIQEIVRVLQSEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ60</accession>
    <name>D7VQ60_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetoacetate-CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">acsA</name>
        <name evidence="3" type="ORF">HMPREF0766_13114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.16" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994061.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13114"/>
    <dbReference type="EnsemblBacteria" id="EFK55911">
        <property type="protein sequence ID" value="EFK55911"/>
        <property type="gene ID" value="HMPREF0766_13114"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_3_10"/>
    <dbReference type="OrthoDB" id="141801at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="2">
        <location>
            <begin position="36"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="100"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK55911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="639" mass="72428" checksum="6F31F81543F6BBC8" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ65</accession>
    <name>D7VQ65_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="4">5.5.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994066.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13119"/>
    <dbReference type="EnsemblBacteria" id="EFK55916">
        <property type="protein sequence ID" value="EFK55916"/>
        <property type="gene ID" value="HMPREF0766_13119"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021486_0_0_10"/>
    <dbReference type="OrthoDB" id="669352at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="PTHR11510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Inos-1-P_synth" evidence="3">
        <location>
            <begin position="246"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK55916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="442" mass="49175" checksum="D64C308660CA043B" modified="2010-10-05" version="1">MENQVKEASGKLGILIPGLGAVATTLIAGVAAINKGLSLPIGSVSQLSRIRLGKRTEDRNPLIKDFVPLAKLEDIVFGGWDVYEDNVYVAASKAKVLEQGQLDQVKDVLENIKPMKAVFDKNFVKNLDGTHIKSETTRRELADAARKDIRDFKEQNGLDRVVIVWCGSTERYIETNDAFSTVAKLEEALDNDDKRIPPSMIYCYAALMEGVPYVNGAPNLTCDVPAIEELAQTNGVAIAGKDFKTGQTLMKTIVAPGLQARALGVEGWFSTNILGNRDGLVLDDPENFKTKEVSKLSVLEEILDAKKNPELYGDLYHKVRINYYPPHGDNKESWDNIDIFGWMGYKMQIKINFLCRDSILAAPVALDLALFIDLAQRAGMSGIQEWLSFYLKSPQTAPGLPPEHDIFKQLMKLQNTLRHMMGEDLITHLGLDYYQELVDSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQF9</accession>
    <name>D7VQF9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13213"/>
    <dbReference type="EnsemblBacteria" id="EFK56010">
        <property type="protein sequence ID" value="EFK56010"/>
        <property type="gene ID" value="HMPREF0766_13213"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1467328_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="184" mass="21308" checksum="FD51B511DD432A48" modified="2010-10-05" version="1">MRRLFFLFIIMVFICGCTGMPEKFTSSQDAFQYISDRENGFISDTLLPSQVKINVQVLPSVLIQKTNNPTLIKYFNVQFSYQGNELLAQLPSEDYGTYVQLFSFGMDQKIYLIDKNGKSYYPSMINYQPSYKAGRSNDLLVVFDEELPDDDLKLSIDEFGLNLGRLNFSVNKEQLNYKPFIDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQL4</accession>
    <name>D7VQL4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_13268</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994377.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13268"/>
    <dbReference type="EnsemblBacteria" id="EFK56065">
        <property type="protein sequence ID" value="EFK56065"/>
        <property type="gene ID" value="HMPREF0766_13268"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_5_5_10"/>
    <dbReference type="OrthoDB" id="1911275at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="211" mass="24256" checksum="9C15F8A3ACD44CBF" modified="2010-10-05" version="1">MKEDSLSYKAYLEIRKKILSNQLVGGARLIESFWADKLSVSRVAIREAFMRLAGEQLVEFGGKGGCFVKKMTADDIKDIRELRELLEVGALKILFTKRDKAVIKELELICDDFSSMVEKGYYGGACEADVRFHEKIIESTGNERLLHIYHNSNIPLFHLKLGNALSHMDDYKQTEVEHRKIVEYLKEGKLKESIDTLLEHLDRGEKESIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQS8</accession>
    <name>D7VQS8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994458.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13332"/>
    <dbReference type="EnsemblBacteria" id="EFK56129">
        <property type="protein sequence ID" value="EFK56129"/>
        <property type="gene ID" value="HMPREF0766_13332"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033R6A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1626004_0_0_10"/>
    <dbReference type="OrthoDB" id="1602637at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="162" mass="19357" checksum="06889DBEE930DCC3" modified="2010-10-05" version="1">MKKMYNDVVELLPEMIHCFNNHSMFDILEEGDIISFIPFEDEAVAKDFVAQTNQMLADYFEVDDELCYSEDSYLDNHDNPVFFWKDYLNCFFTLELVGDEMSNEGFEGTGYGMYKIVEIAYINEVNKRLKQRRINGLRLEYKVKSTPMDRNKHWNRTYDKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQZ0</accession>
    <name>D7VQZ0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13394</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994534.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13394"/>
    <dbReference type="EnsemblBacteria" id="EFK56191">
        <property type="protein sequence ID" value="EFK56191"/>
        <property type="gene ID" value="HMPREF0766_13394"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_4_1_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="118"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="194" mass="23197" checksum="09CD80EF1FB86B92" modified="2010-10-05" version="1">MEEKSLLHKVKNGDIDAFNALYTLYAPLLYNKCLKLLKDYEILNDLVQDTFLKIWHLRTEIDPEKGFRTFIFRIAENMVMDIFRRISRDKKLQEELWYNLVENSFHFNDHVIDKEKKMILEQAISQLSPRKKEIWILCKVNEKSYKEVAQQLGISVSSVSNQLVTAMKDIKDYIHKNYHNDYLMALTLLYLMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRB3</accession>
    <name>D7VRB3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-phosphoerythronate dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.290</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pdxB</name>
        <name evidence="5" type="ORF">HMPREF0766_13517</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.290" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13517"/>
    <dbReference type="EnsemblBacteria" id="EFK56314">
        <property type="protein sequence ID" value="EFK56314"/>
        <property type="gene ID" value="HMPREF0766_13517"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033711">
        <property type="term" value="F:4-phosphoerythronate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="7"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="113"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="329" mass="36336" checksum="D6ED790C03931013" modified="2010-10-05" version="1">MKDIMKVYISRNVPQEGLNYLTEHGLTYTVNMENKKLTQEEVIIECQSADLLLNVGGVPLDQHFFDNCAHLKGIALASVGYDHVDMDAASKAGIPVSNTPDVLSGATADVAFLLMLAVSRKAFYRANEIREGKWNDFEFTKDLGIELNGKTLGIYGLGRIGLELARKAQAAYGMKVIYHNRHPNETAKRVLNAEYVNFDELLTRSDVLSVHANLSPETQYRFNKETFARMKNSAILINTGRGKIVHEQDLYTALVNGDIWGAGLDVTDPEPMKADSPLLTLPSVCVLPHIGSATIETRTNMIKMAANNLIAASKSNHMPQIVNVEVYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRQ4</accession>
    <name>D7VRQ4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994938.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13658"/>
    <dbReference type="EnsemblBacteria" id="EFK56455">
        <property type="protein sequence ID" value="EFK56455"/>
        <property type="gene ID" value="HMPREF0766_13658"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZAVP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092723_0_0_10"/>
    <dbReference type="OrthoDB" id="1118154at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12105">
        <property type="entry name" value="HmuY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025921">
        <property type="entry name" value="HmuY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14064">
        <property type="entry name" value="HmuY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="262" mass="30160" checksum="69FB1BE13D720631" modified="2010-10-05" version="1">MMKYLNILNPKIHMEDKNLIMNELYPLHWFRKIGFGLLSLLFILSTSCSKNEDDPRPSLEDGKSTVVYDLPGDTEASMAGNVDGKEKRDFYTFLFRFRDKRQIWIKTKADSLQWLKSKDWDLAFTGPYNSEIYVNNANYEYNPGFGGQASNTAVVLVDQAYENVTVAPDDATFSKSEVNKIGWASSQGSYGWFRYSLDTHIMQALPNRTYILRLPDGRYAKLQLINAYKGNPPAVTNLNWPAPYYTFRYFVQQDGSKNLTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRR3</accession>
    <name>D7VRR3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13667</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994959.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13667"/>
    <dbReference type="EnsemblBacteria" id="EFK56464">
        <property type="protein sequence ID" value="EFK56464"/>
        <property type="gene ID" value="HMPREF0766_13667"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_2_1_10"/>
    <dbReference type="OrthoDB" id="1579676at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="83"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="119"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="400" mass="44052" checksum="3067EB34D85EBDCE" modified="2010-10-05" version="1">MKKSLFTNLLEIYRLSFNSVKPFNSVKIAFYLSGALLYSCSTGTSKPADATPPPAALPVMTIQMADETTYQEYPASIEALANVEIRPQIEGILDHIYVDEGQKVTKGQLLFKINDRPYQEQLNQAKANLQVAQASLENAELEVEKKNRLVNNKVLTDFQLQTAVSARNAAKASVQQAKSAIEAAKINVGYTLIRASSDGYIGRLQKKQGSLITPMDAQALTGLSDIRDLHVYFSLSENDFVQFKNNAKGKSIEEKIKNLPPVTLVLSDQQNYEHTGKIDMVDGQFDKNTGSITLRATFPNPDGLLRSGNTGRIRLSKSIDQALLVPAAATLEIQDKIFVYTVGKDNKVMQQPIQVLGKTGTNYLVKDGLKEGDRIVVKGIDMLQEGQVIAPQTEKVDDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRR4</accession>
    <name>D7VRR4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_13668</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994963.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13668"/>
    <dbReference type="EnsemblBacteria" id="EFK56465">
        <property type="protein sequence ID" value="EFK56465"/>
        <property type="gene ID" value="HMPREF0766_13668"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_40_3_10"/>
    <dbReference type="OrthoDB" id="1570162at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK56465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="199" mass="23182" checksum="4BBE2872A2BA2661" modified="2010-10-05" version="1">MGSKERIQRLKDENRSKILDASLQIVKEEGWHALSMRKIADIIEYTAPMIYEYFANKEAILIELANQGYIMLSVRVKEAKLQESELEKQLEAMWFTYWNFAFEEKELYQLMFGVGTQCCGFEKSFLCVESHGKLISDVIREIMKDQQPSEELICRKYFTFWSVIHGLISINLVNQGNGDTTNQQVLRDAIYGITRSLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRU7</accession>
    <name>D7VRU7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coproporphyrinogen III oxidase, aerobic</fullName>
            <ecNumber evidence="5">1.3.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hemF</name>
        <name evidence="5" type="ORF">HMPREF0766_13701</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995054.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13701"/>
    <dbReference type="EnsemblBacteria" id="EFK56498">
        <property type="protein sequence ID" value="EFK56498"/>
        <property type="gene ID" value="HMPREF0766_13701"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026169_0_1_10"/>
    <dbReference type="OrthoDB" id="1086432at2"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="PTHR10755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000166">
        <property type="entry name" value="Coproporphyri_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="SSF102886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="298" mass="34191" checksum="CED0034A362D4E5E" modified="2010-10-05" version="1">MITKEQIAETYKSIQQEITDALEVLDGGAKFQEELWERDGGGGGRTRIIQAGNLIEKGGVNFSAVHGTLPEPVKKAFGVEDDQFFATGVSIVLHPNHPLVPIIHMNIRYFELNEQTRWFGGGIDLTPHYVCKEDAQHFHQTLKAVCDKHNSEFYSEFKTWADNYFFIRHRDETRGIGGVFYDRLTPEKTNMSYKQIFDFSCDLGRTFAGVYAELANRHRHESYSEEQKNWQMLRRGRYVEFNLVYDAGTKFGLETNGRIESILMSLPAQANWAYDFKAQPGSKEEETLSLLKKGIDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRZ0</accession>
    <name>D7VRZ0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease V</fullName>
            <ecNumber evidence="1">3.1.21.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Deoxyinosine 3'endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Deoxyribonuclease V</fullName>
            <shortName evidence="1">DNase V</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">nfi</name>
        <name evidence="2" type="ORF">HMPREF0766_13744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.</text>
            <dbReference type="EC" id="3.1.21.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the endonuclease V family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.7" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995164.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13744"/>
    <dbReference type="EnsemblBacteria" id="EFK56541">
        <property type="protein sequence ID" value="EFK56541"/>
        <property type="gene ID" value="HMPREF0766_13744"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047631_1_1_10"/>
    <dbReference type="OrthoDB" id="1681607at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043737">
        <property type="term" value="F:deoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06559">
        <property type="entry name" value="Endonuclease_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00801">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="PTHR28511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with target DNA" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="235" mass="26065" checksum="D179224AB54B93A8" modified="2010-10-05" version="1">MDYNKLTLPEATEIQEDLRHKLRFDRPDAQVIYTIGGADISYNKGSEILYAAIVILNYPDMTLRSYALATGHSSFPYIPGYLAFREVPALLNAWSLLPVRPDVLVLDGQGILHPRQMGIASHFGVLTGQATIGCAKNSLYGRHADLARFKGSSTPIVDGVKHIGHLLRTKEAVKPVFISPGYGLSVNKSLEVIRQSTGRYRIPEPTRLAHNIVNDFRTGKLNPGYHEVEQPLSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS40</accession>
    <name>D7VS40_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_13794</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995283.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13794"/>
    <dbReference type="EnsemblBacteria" id="EFK56591">
        <property type="protein sequence ID" value="EFK56591"/>
        <property type="gene ID" value="HMPREF0766_13794"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_10_0_10"/>
    <dbReference type="OrthoDB" id="439303at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107232" evidence="5">
        <location>
            <begin position="21"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="121"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="276"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK56591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="776" mass="86938" checksum="47DE1298657789A6" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS97</accession>
    <name>D7VS97_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13851"/>
    <dbReference type="EnsemblBacteria" id="EFK56648">
        <property type="protein sequence ID" value="EFK56648"/>
        <property type="gene ID" value="HMPREF0766_13851"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_6_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="149" mass="17441" checksum="1CC248056CED46FD" modified="2010-10-05" version="1">MKTDKISMTMKNEIENKLRDKNTKPTSMRILVYDFLASQQVALSLSEIENYFYPADRITLYRTLKTFEEKGIVHSIQENNTSKYRLCSDDCSEQTHRDWHLHLYCKICKQTTCRTDISFKQPSDAAVQIDEVRLFAKGICENCLPKSMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSC7</accession>
    <name>D7VSC7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995492.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13881"/>
    <dbReference type="EnsemblBacteria" id="EFK56678">
        <property type="protein sequence ID" value="EFK56678"/>
        <property type="gene ID" value="HMPREF0766_13881"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1467329_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="184" mass="20900" checksum="A36544BB9B06B7C7" modified="2010-10-05" version="1">MINPPEKLSENNLLRGRHTEGTKMENSGASRKNLLLHSLLYAVIWAVYMAVIMPLADKVTGPCEGTPGHDYTGAFIVLPLYFVLFAGWIYYISRKMIKMVHIWLLILMILFVIPVGIAIIVAGIFYMDSMISFIQDSEWFSYFYEYGCYADLEVRELPILTGTSIGLGLSLYALLLVFNRKEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSH6</accession>
    <name>D7VSH6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAF domain protein</fullName>
            <ecNumber evidence="4">4.2.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UxaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.7" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995582.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13930"/>
    <dbReference type="EnsemblBacteria" id="EFK56727">
        <property type="protein sequence ID" value="EFK56727"/>
        <property type="gene ID" value="HMPREF0766_13930"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029189_0_0_10"/>
    <dbReference type="OrthoDB" id="889365at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008789">
        <property type="term" value="F:altronate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11613">
        <property type="entry name" value="SAF_AH_GD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007392">
        <property type="entry name" value="Gal/Altron_deHydtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044144">
        <property type="entry name" value="UxaA/GarD_SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04295">
        <property type="entry name" value="GD_AH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAF" evidence="3">
        <location>
            <begin position="15"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="554" mass="60085" checksum="78DE15BB028CF2C0" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSM5</accession>
    <name>D7VSM5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_13979</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995647.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13979"/>
    <dbReference type="EnsemblBacteria" id="EFK56776">
        <property type="protein sequence ID" value="EFK56776"/>
        <property type="gene ID" value="HMPREF0766_13979"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002934_0_2_10"/>
    <dbReference type="OrthoDB" id="439010at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001092">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107892" evidence="6">
        <location>
            <begin position="24"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="site" description="May be important for catalysis" evidence="5">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001092-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="465" mass="54414" checksum="FA10DFB8517486D6" modified="2010-10-05" version="1">MRKRSFLKVCLMLGLLSVSQLHAQDKTPSWAQKANDDKENRMKWWTHDRFGMFIHWGLYAVPARHEWIQQMEQMSTEKYKEKYFNLFDPDLYNPKEWAAYAKKAGMKYVVITTKHHEGFSLWDTKVSDYKAPNTPAKQDLLKPFVEACRAEGLKIGFYYSVIDWHHPDFTIDGTHALRNNQEARKSNANRNMDNYRKFLKDQVRELLTNYGKIDMLFWDFSYPGKDGKGHNDWDSEGLVKLARELQPQIIMNDRLDLMDKDWGWDYKTPEQFMPNKWPEHNGKKVAWETCQTFSGSWGYHRDENTWKSTNQLIAMLIEVVSKGGNLLLNVGPTARGYFDDRATNRLEEMGQWMKYNSKSIYGCTAAPEGFQKPDNTYLTYNPETKRMYIHLLQWPFKTLYLPGFKDKVKYAQFLHDNSEIKYTSRSSASAGEHMAITAGEGDLIMDLPVVKPNVEIPVIELILND</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSR5</accession>
    <name>D7VSR5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BNR/Asp-box repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14019"/>
    <dbReference type="EnsemblBacteria" id="EFK56816">
        <property type="protein sequence ID" value="EFK56816"/>
        <property type="gene ID" value="HMPREF0766_14019"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064269_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028203">
        <property type="entry name" value="PSII_CF48-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14870">
        <property type="entry name" value="PSII_BNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107894" evidence="1">
        <location>
            <begin position="20"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="PSII_BNR" evidence="2">
        <location>
            <begin position="40"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="346" mass="37409" checksum="55358923F77B49A1" modified="2010-10-05" version="1">MGMKKLLFLLFMSPALLFAQNKQYHIIPLIQDVKSSFRGLAVVSDQILWISGSNGTVGKSLDGGKSWDWVNPAGFESYDFRDIQAFNAKEAVIVNAGSPAVILRTSDGGKNWISTYENNHPDIFLDGMDFWDRKRGIAFGDPIDGRLQLLYSSDKGKNWNDISANLKQVMKTGEASFAASGSTICTQPHGNVWIATGGSVSHIYFSGDYGQHWEQYACPITQGKSTTGVFSIAFIDHMTGVVVGGDYAQDKENANNILLTTDGGKNWTAPAKPVSGFRSSVVYVNRQTLFATGTSGTDVSEDGGNTWTKIADSSFNVIGKSQSGNKIFLTGSKGNVAVLQVQSSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSV1</accession>
    <name>D7VSV1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_14055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995830.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14055"/>
    <dbReference type="EnsemblBacteria" id="EFK56852">
        <property type="protein sequence ID" value="EFK56852"/>
        <property type="gene ID" value="HMPREF0766_14055"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017518_3_0_10"/>
    <dbReference type="OrthoDB" id="1249292at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="244"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="432" mass="48191" checksum="FB3AE44ED1630732" modified="2010-10-05" version="1">MIAVEKNNKKTIRAWSMYDWANSAYNLVITSTIFPVYYTTITNTKEHGDTVTFFGIEVVNTALSNFALAFAYLFMAVSLPFITSFADATGRKKMLMKLFTYIGGAACMGLYFFKLETLEMSIIFFALAAMGYIGGVAFNNSYLPLIATVDQQDRVSAQGFAYGYVGCVLLQIICFVFVLKPEWFGIMDLSFPARLSFFLVGLWWVGFAQIPFRVLPSNSPMPGTQGVPLIRTVKQEFLKVWHRIAQIEGIKRFLPAYFFYAIGVQTIMIVAAAFGEKVLHLGAPKLIGTILLIQLVAIAGAYLMSALASRIGNIAVLIMVVVIWIAICIGAYFLTNEIQFYIMAVLVGLVMGGIQSLSRSTYSKLLPQNIEDTTAFFSFYDVTEKLAIVVGLFSFGLIEQLTHNIRYSALFLSLFFVIGLLLLFRVLKFNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT41</accession>
    <name>D7VT41_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14145"/>
    <dbReference type="EnsemblBacteria" id="EFK56942">
        <property type="protein sequence ID" value="EFK56942"/>
        <property type="gene ID" value="HMPREF0766_14145"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50334BV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_933525_0_0_10"/>
    <dbReference type="OrthoDB" id="607827at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="298" mass="34899" checksum="C3687F4C0F0ADC03" modified="2010-10-05" version="1">MDKLLKNAFKMQIQSKEGFEFEEFIDELFLLKYGVDNYTPIRRNKDKGNDGTILPEQKILACYAPRKYSKTDFETKVLGATNKEGDFEKYQKNWKDKFPNWEMYVNHEVSPEQFTLIQSLDGDTSIKGIDQILSIVDELVSSKKRKLAAYLGIENFFIQDYIQEIINDLLNASSEEDKALHFDRKSLVPPQKKIELNFEQEDWDGMNSEMVLVMAEFNTITNILSGYNDDEINTLKRRVINDYNKLSGNFKDRLYNLTDQYTTAYGNIKDDEYVKCVKSILLYMFEQCLIGRKTENEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT54</accession>
    <name>D7VT54_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996045.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14158"/>
    <dbReference type="EnsemblBacteria" id="EFK56955">
        <property type="protein sequence ID" value="EFK56955"/>
        <property type="gene ID" value="HMPREF0766_14158"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178450_1_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="68" mass="7718" checksum="1F72834E35F553CC" modified="2010-10-05" version="1">MEIILQSTITCPNCGHKKEETMPTDACQYFYECEKCKQVLKPKQGDCCVYCSYGSVPCPPIQQDKKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT65</accession>
    <name>D7VT65_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative toxin-antitoxin system, toxin component, Fic family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996058.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14169"/>
    <dbReference type="EnsemblBacteria" id="EFK56966">
        <property type="protein sequence ID" value="EFK56966"/>
        <property type="gene ID" value="HMPREF0766_14169"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055403_0_1_10"/>
    <dbReference type="OrthoDB" id="1838027at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018873">
        <property type="entry name" value="KilA-N_DNA-bd_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10543">
        <property type="entry name" value="ORF6N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORF6N" evidence="1">
        <location>
            <begin position="15"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="292" mass="33493" checksum="E7767972968F270E" modified="2010-10-05" version="1">MTDITISQKEIAPLIHTIRDKQVILDADLAMLYQVETKALNRVVKRNQNRFPETFCFQLSEQEVKSLKYQFGTSNVGRGGRRTLPFAFCEQGVAMMSALLRSDIAVKVSIEIMNAFVEMRKMLISNASLFHRLNNIELKQLQADQKFEEIFKALESDKLHSENGIFYNGQVFDAYAFVSDIVRSAKSSIILLDNYVDDTVLTLLGKRKENVTATIYTKTISNQLRLDVQRYNSQYAPIEIEVFSDAHDRFLIIDNAELYHIGASLKDLGKKWFAFSRMDIEVGRMLQILNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT66</accession>
    <name>D7VT66_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Omega-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Relaxing enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Swivelase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Untwisting enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">topB2</name>
        <name evidence="12" type="ORF">HMPREF0766_14170</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996062.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14170"/>
    <dbReference type="EnsemblBacteria" id="EFK56967">
        <property type="protein sequence ID" value="EFK56967"/>
        <property type="gene ID" value="HMPREF0766_14170"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_5_2_10"/>
    <dbReference type="OrthoDB" id="100725at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025589">
        <property type="entry name" value="Toprim_C_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13342">
        <property type="entry name" value="Toprim_Crpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK56967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="694" mass="77964" checksum="CC172833AA3E9AC8" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT78</accession>
    <name>D7VT78_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sigma factor regulatory protein, FecR/PupR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996101.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14182"/>
    <dbReference type="EnsemblBacteria" id="EFK56979">
        <property type="protein sequence ID" value="EFK56979"/>
        <property type="gene ID" value="HMPREF0766_14182"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050192_1_0_10"/>
    <dbReference type="OrthoDB" id="1381035at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032508">
        <property type="entry name" value="FecR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16344">
        <property type="entry name" value="DUF4974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FecR" evidence="1">
        <location>
            <begin position="185"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4974" evidence="2">
        <location>
            <begin position="318"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="391" mass="44353" checksum="B952054C2F698B88" modified="2010-10-05" version="1">MKDKKAFEILYTKYVEGSLSAEELLEWVEVFQYPENEQYLAELIGRTFDTYKVPEDPEAAKQAFHRFERLIDTEDTSSDTPSLPLNKSVFSIFRQWKYVAAALLLSIASYGIYQYTLQTTSQSRIANISKPDVSPGSNKAILKMEDGSEIKLGPQGELIVKGDRLEDGAGNMLLKGQLKETWQSIEVPKGGQYTIVLSDGTKVWLNADSKMRFPVEFVAQQRQVQLQGEAYFEVTKDPSRPFIVKSAQQQIEVLGTWFNISAYPDEPAVTTLVSGKVNVSAFGKQVALTPGMQSVADDQQLHSKQVEVEPAVAWKDAKFVFVKEPLEDIIRKLERWYNVDFVIQPGSEELKKKTFSGSLSRNGKLSEILNLFKITETIRFEITERRVYLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT88</accession>
    <name>D7VT88_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996132.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14192"/>
    <dbReference type="EnsemblBacteria" id="EFK56989">
        <property type="protein sequence ID" value="EFK56989"/>
        <property type="gene ID" value="HMPREF0766_14192"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080344_3_1_10"/>
    <dbReference type="OrthoDB" id="1825422at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107659" evidence="1">
        <location>
            <begin position="27"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="240" mass="26568" checksum="CC995DE617F16584" modified="2010-10-05" version="1">MHTVIKSTFVLAAASLLFFASCNSDSKDNKNRIRVSGEGKIRIMPDQVTLTIDAGFTKPRMVDAVRETQNTVDSVIAILQKYGSNKEDIKTSSVSANKAYEYINNSNKFVGYQAQQTIDFVLHDLTKFTELTGKLLETKISGISSVQFNHSKADSILREADLIAYDDAFKSAQKLAKRADVEIGKLLFISNDGSSSGDAGGYQTRMQLETFNKAYGGAGFKIAPEVLEFKRNIYTEFELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTB8</accession>
    <name>D7VTB8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PQQ enzyme repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_14222</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996217.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14222"/>
    <dbReference type="EnsemblBacteria" id="EFK57019">
        <property type="protein sequence ID" value="EFK57019"/>
        <property type="gene ID" value="HMPREF0766_14222"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021028_0_0_10"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032285">
        <property type="entry name" value="Metallophos_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025666">
        <property type="entry name" value="PQQ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16371">
        <property type="entry name" value="MetallophosN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13570">
        <property type="entry name" value="PQQ_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107570" evidence="1">
        <location>
            <begin position="19"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="MetallophosN" evidence="4">
        <location>
            <begin position="37"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="113"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="PQQ_3" evidence="3">
        <location>
            <begin position="701"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="795" mass="88024" checksum="2647DD12020A516E" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTC6</accession>
    <name>D7VTC6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_14230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996244.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14230"/>
    <dbReference type="EnsemblBacteria" id="EFK57027">
        <property type="protein sequence ID" value="EFK57027"/>
        <property type="gene ID" value="HMPREF0766_14230"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_2_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107571" evidence="5">
        <location>
            <begin position="31"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="127"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="452"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK57027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1024" mass="114399" checksum="534DAD513B9722B3" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTG3</accession>
    <name>D7VTG3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">7TM diverse intracellular signaling</fullName>
            <ecNumber evidence="4">2.7.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pgtB</name>
        <name evidence="4" type="ORF">HMPREF0766_14267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.-" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996340.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14267"/>
    <dbReference type="EnsemblBacteria" id="EFK57064">
        <property type="protein sequence ID" value="EFK57064"/>
        <property type="gene ID" value="HMPREF0766_14267"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_105_2_10"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011623">
        <property type="entry name" value="7TMR_DISM_rcpt_extracell_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011622">
        <property type="entry name" value="7TMR_DISM_rcpt_extracell_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07695">
        <property type="entry name" value="7TMR-DISM_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07696">
        <property type="entry name" value="7TMR-DISMED2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="461"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="716" mass="81287" checksum="4BB8F9B87730A42F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTI9</accession>
    <name>D7VTI9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase dimerization domain protein</fullName>
            <ecNumber evidence="3">3.4.17.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996392.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14293"/>
    <dbReference type="EnsemblBacteria" id="EFK57090">
        <property type="protein sequence ID" value="EFK57090"/>
        <property type="gene ID" value="HMPREF0766_14293"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_11_1_10"/>
    <dbReference type="OrthoDB" id="906744at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="266"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="516" mass="57084" checksum="B7A813CA125355CB" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTQ7</accession>
    <name>D7VTQ7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribonuclease, Rne/Rng family</fullName>
            <ecNumber evidence="6">3.1.4.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rng</name>
        <name evidence="6" type="ORF">HMPREF0766_14377</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001733.1">
        <property type="nucleotide sequence ID" value="NZ_GL379777.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14377"/>
    <dbReference type="EnsemblBacteria" id="EFK55816">
        <property type="protein sequence ID" value="EFK55816"/>
        <property type="gene ID" value="HMPREF0766_14377"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1530">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003468_5_3_10"/>
    <dbReference type="OrthoDB" id="1209444at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK55816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="517" mass="58645" checksum="2824FB6A47DD5E91" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTT0</accession>
    <name>D7VTT0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002216.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14400"/>
    <dbReference type="EnsemblBacteria" id="EFK55709">
        <property type="protein sequence ID" value="EFK55709"/>
        <property type="gene ID" value="HMPREF0766_14400"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071501_0_0_10"/>
    <dbReference type="OrthoDB" id="1865374at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="234" mass="27282" checksum="D327DA58A666FC30" modified="2010-10-05" version="1">MNRDVYGEALQDYFATGETASPLLLHSSYGDIEEMPVDIFYREEEDFTELEFIALSLCDGKVLDVGAGTGVHALYLQQKGFEVDALEISETASHIMKQRGIDTIINDDIFNVKDQKYNTLLFLMNGIGLAGDLEGFRRLLRHAKSLLDNRGQLLFDSSDISYLYEEYRIKRPDYYFGEINYQYEYRGVKGTPFKWLYLDQQTLIKVAREENWVVQILFEDDQDQYLVRMEPRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VG89</accession>
    <name>D7VG89_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001829.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10008"/>
    <dbReference type="EnsemblBacteria" id="EFK60064">
        <property type="protein sequence ID" value="EFK60064"/>
        <property type="gene ID" value="HMPREF0766_10008"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZBSZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1249959_0_0_10"/>
    <dbReference type="OrthoDB" id="1554173at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK60064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="224" mass="25841" checksum="455C47490F9C7C40" modified="2010-10-05" version="1">MEKYKVDYSETSHFKGIRIVYEYLEEGLDYARENGIPEVCVWTDGDWNKLTINFDFLKDRDFIETFHWLVPMSKKSDINGLKYFHKLKNLCWSVAGEFNLDLSIFPILEKLNIGYGPKIHGWDKLTSLKELLIGSIKQADLSFLNHAINLEYLRIIGGSFESIEGLEHCSKLTTLFLQKCNALTKLQSTICYLDKLQQLNLEGCKKVNTEEQLAGLAIKYVSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGA2</accession>
    <name>D7VGA2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001865.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10021"/>
    <dbReference type="EnsemblBacteria" id="EFK60077">
        <property type="protein sequence ID" value="EFK60077"/>
        <property type="gene ID" value="HMPREF0766_10021"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032ZSH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173112_0_0_10"/>
    <dbReference type="OrthoDB" id="1980477at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK60077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="90" mass="10436" checksum="B49B0417ECF243E1" modified="2010-10-05" version="1">MLPFTQNSLDKIEALFKEFGFKLRYEKGNFRTGACVLQHSKVIVVNKFSNLEVKIQSLIQILHEIPADEALLDEKQRTLYQAIRQTKLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGL2</accession>
    <name>D7VGL2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CinA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cinA</name>
        <name evidence="3" type="ORF">HMPREF0766_10131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CinA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996661.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10131"/>
    <dbReference type="EnsemblBacteria" id="EFK59214">
        <property type="protein sequence ID" value="EFK59214"/>
        <property type="gene ID" value="HMPREF0766_10131"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_9_2_10"/>
    <dbReference type="OrthoDB" id="1834406at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00226_B">
        <property type="entry name" value="CinA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041424">
        <property type="entry name" value="CinA_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008135">
        <property type="entry name" value="Competence-induced_CinA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18146">
        <property type="entry name" value="CinA_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006728">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00200">
        <property type="entry name" value="cinA_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="2">
        <location>
            <begin position="4"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="419" mass="45884" checksum="FC03D36B2479B262" modified="2010-10-05" version="1">MTAEIITIGDEILIGQIIDTNSAWIAKQLKNINISIGQITSVSDSKEAIRQTLQEAAGRADIIIVTGGLGPTKDDITKITAADYFGTHLMRDAKVLAHVEDFFKQRGLEMLEINLQQADILANSEVLFNDVGTAPGMFVRQDNKYYFFIPGVPFEMKFLVTNRILPILSTLDIGQSIWTQNIITAGIGESFLANTIADIEDALPDYIKLAYLPKYGSVRMRLTAIGQDASALRQETEQFANRIVDRVRSHVISTEDLTIEEVIIKEFAKRNLTLSTAESCTGGFLAAQLTAVPGCSQIFTGGTIPYSNKLKMQLLGVTEATLSSYGAVSEQTVIEMANGSKKNFETDYAIATSGIAGPDGGTSEKPVGTVWIAIAGKEKVITKKCQFTPNRQVNIELATAYAYNMLWNLFHTENNFSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGP6</accession>
    <name>D7VGP6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996772.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10165"/>
    <dbReference type="EnsemblBacteria" id="EFK59248">
        <property type="protein sequence ID" value="EFK59248"/>
        <property type="gene ID" value="HMPREF0766_10165"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZE9X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043496_1_0_10"/>
    <dbReference type="OrthoDB" id="1232973at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005077">
        <property type="entry name" value="Peptidase_C11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37835">
        <property type="entry name" value="PTHR37835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03415">
        <property type="entry name" value="Peptidase_C11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="374" mass="42452" checksum="16F361137A9EEAF6" modified="2010-10-05" version="1">MKRLNIYFILLCFLLLCSCGKERLDIVPKPPVSRTVIVYMGGNNNLQNETYEKIESLKQGYKAGMGRLLIYQAIRDDVPRLLEIVADPSGKGVEKVLKTYEKHNAADATVFSQVLAEVKQTAPAQSYGLILFSHASGWLPQGTLIKPRTLLQNSESDLELRDFAAALPDNSFDFIIFESCFMTGIEVIYELKDKTRYIVASSAEILSPGFTPIYPELLPYLYTKEADLKGFSKQVFDYYNNQSGDYRSATISMIDVRPLSELATWARINATKPLQESELRLVQHFDRYANYRLFFDFADYYSRRTSAESQTNLRSILNKIVVYKASTPQFLLGQGGFTIRTHSGLTSYIPQAGFPYLNAEYAKLKWTADTQINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGU9</accession>
    <name>D7VGU9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA protecting protein DprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dprA</name>
        <name evidence="3" type="ORF">HMPREF0766_10218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996901.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10218"/>
    <dbReference type="EnsemblBacteria" id="EFK59301">
        <property type="protein sequence ID" value="EFK59301"/>
        <property type="gene ID" value="HMPREF0766_10218"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029601_0_3_10"/>
    <dbReference type="OrthoDB" id="1881437at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041614">
        <property type="entry name" value="DprA_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17782">
        <property type="entry name" value="DprA_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DprA_WH" evidence="2">
        <location>
            <begin position="304"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="370" mass="41262" checksum="AF5AD6A68DBE19FC" modified="2010-10-05" version="1">MNTLLQIALTKVKGIGPRLSRSLLSHCDTVEAIFTASKKQLLTIPGINIAIIERLRSKELLLEAEKELAFISAHDIDLLWIEDNRYPRRLRECDDAPLVLYYKGSESLNPARTISIVGTRKATAYGQRICDELIQELRLPGIQIISGLAYGIDIYAHQAALRHQIPTLGIMGHGLDRIYPAAHRTIAAEMLSCGGLLTEFTSGTNPDRQNFPMRNRIIAGMADVTIVIEAASRGGALITAEIANTYNRDVCAFPGGIDQESSAGCNYLIKTNRAHLIRNASDLFYMMNWEQEQQQKPSAQLSLLPPQLSEEQEKIYQFLQQQNPAPIDEIAIHCALPQSQLAISLLELEMEGIILSMPGKVYKLHHIYQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH45</accession>
    <name>D7VH45_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10314"/>
    <dbReference type="EnsemblBacteria" id="EFK59397">
        <property type="protein sequence ID" value="EFK59397"/>
        <property type="gene ID" value="HMPREF0766_10314"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3276842_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="41" mass="4939" checksum="DE230BDD210AD3AA" modified="2010-10-05" version="1">MPGVQVYFIVKNPYMRIGNARNADNWILSLYRVAYQQRKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH55</accession>
    <name>D7VH55_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber evidence="8">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IGP synthase glutaminase subunit</fullName>
            <ecNumber evidence="8">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">IGP synthase subunit HisH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">ImGP synthase subunit HisH</fullName>
            <shortName evidence="8">IGPS subunit HisH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">hisH</name>
        <name evidence="11" type="ORF">HMPREF0766_10324</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="8"/>
    <dbReference type="EC" id="3.5.1.2" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997171.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10324"/>
    <dbReference type="EnsemblBacteria" id="EFK59407">
        <property type="protein sequence ID" value="EFK59407"/>
        <property type="gene ID" value="HMPREF0766_10324"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071837_0_0_10"/>
    <dbReference type="OrthoDB" id="1726024at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701">
        <property type="entry name" value="PTHR42701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000495">
        <property type="entry name" value="Amidotransf_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="5"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000495-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK59407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="197" mass="22010" checksum="D7EACC6855E5BF48" modified="2010-10-05" version="1">MIGIINYGAGNIFSLTAALDRVGLSYMMINLPEEIDQCDRIIIPGVGHAGAAMQKLRESGLSEYIHTIKKPVLGICVGMQLMTDFSEEGNAGLLKIVPLQTLHFKERIAQKVPHMGWNSISPSKGNPLFLHIEDNAYFYFVHSYFIEYHEDYTIAKCDYDVPFSAAMSKGNFYGVQFHPEKSGKAGEQLLLNFSKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHF5</accession>
    <name>D7VHF5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, group 2 family protein</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10424"/>
    <dbReference type="EnsemblBacteria" id="EFK59507">
        <property type="protein sequence ID" value="EFK59507"/>
        <property type="gene ID" value="HMPREF0766_10424"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055604_1_0_10"/>
    <dbReference type="OrthoDB" id="724641at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="34"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="366" mass="40980" checksum="AA50548B23217E08" modified="2010-10-05" version="1">MTIVYVALVLYMRNGWASISTFVTSDATPSATVSVLIAARNEEQVIERTINCLLNQDYPKELFEIIVIDDHSTDRTADIVRLYAVKGVKLLQMNESDKLNSYKKKAISNAIDIAQGEIIVTTDADCRMGRQWLSTVIGFFEEYDSYMVSSSVVYSEEKNPFEEAQTLEFLYLIGLGAAGIGNGHPTTCNGANLAYRRDVFYEMDGFKGIDDLASGDDELLLHKVAEKYADKIGFCKSPSAIVYTDAKPDMASFISQRKRWASKSTRYKNKSVIVLGVSIWLFNLAMILSGLLAFLFPSTLGALIFAVIVIKFVVELYFMRPLCEFANRTDLLKYLPILTVGHIIYLVYIGIAGNIGKYDWKGRIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHI4</accession>
    <name>D7VHI4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpmC</name>
        <name evidence="6" type="ORF">HMPREF0766_10453</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997488.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10453"/>
    <dbReference type="EnsemblBacteria" id="EFK59536">
        <property type="protein sequence ID" value="EFK59536"/>
        <property type="gene ID" value="HMPREF0766_10453"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158491_5_1_10"/>
    <dbReference type="OrthoDB" id="2063644at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK59536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="72" mass="7792" checksum="9A4CEE92FC3899B9" modified="2010-10-05" version="1">MKNSEILELSTEELAARLSEEKAALSKLKFAHAVSAIENPNVIKAARRTIARLNTELSARKAAAKKETASEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHK1</accession>
    <name>D7VHK1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase</fullName>
            <ecNumber evidence="3">3.5.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pbpE2</name>
        <name evidence="3" type="ORF">HMPREF0766_10470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.6" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997513.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10470"/>
    <dbReference type="EnsemblBacteria" id="EFK59553">
        <property type="protein sequence ID" value="EFK59553"/>
        <property type="gene ID" value="HMPREF0766_10470"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_0_1_10"/>
    <dbReference type="OrthoDB" id="537440at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107218" evidence="1">
        <location>
            <begin position="24"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="67"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="396" mass="45038" checksum="A6C001FABAC744DA" modified="2010-10-05" version="1">MKLIVAKVLLGLSVISLIGCTSAEERKIKEEKNQAEQDSIRLLYNPNEADKAVDAFMQNLHKKAGFNGNVLIAKKGKIIYEKSFGWANYLLKDSLNIQSQFELASVTKPMTSIAILKLVEEGKLKLDQTVNDFFPDFPYEGITVKMLLTHRSGLPNYVYFADGVWKDKKKGMSNMDAIRLLTEHKPGRYGKPDGRFHYNNSNFMVLGAIIEKVSKQDYAVFLKENVFDPAGMKHTAAYSKAVYEKIPVKVIGHDKVWRRSVVQNFLDGPLGDKGIYSTVEDMFLLDIALREGRLLKQETLDSAYVPRNDPSKKGAFGYGYGWRTFNHNDQHVVYHTGWWHGFRNLYVRDLKNDVTIVLLSNMTNGSLVKLDELYKILGMPILRKNAYNADGDFMVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHL1</accession>
    <name>D7VHL1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997535.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10480"/>
    <dbReference type="EnsemblBacteria" id="EFK59563">
        <property type="protein sequence ID" value="EFK59563"/>
        <property type="gene ID" value="HMPREF0766_10480"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026375_1_0_10"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="384"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="606" mass="69597" checksum="8232AF174FC9D67A" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHQ9</accession>
    <name>D7VHQ9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_10528</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997645.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10528"/>
    <dbReference type="EnsemblBacteria" id="EFK59611">
        <property type="protein sequence ID" value="EFK59611"/>
        <property type="gene ID" value="HMPREF0766_10528"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_0_1_10"/>
    <dbReference type="OrthoDB" id="448804at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="23"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="288"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="579" mass="66126" checksum="7FE64A2D52136557" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHU3</accession>
    <name>D7VHU3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RHS repeat-associated core domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997735.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10562"/>
    <dbReference type="EnsemblBacteria" id="EFK59645">
        <property type="protein sequence ID" value="EFK59645"/>
        <property type="gene ID" value="HMPREF0766_10562"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_270109_0_0_10"/>
    <dbReference type="OrthoDB" id="1639867at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1207" mass="134542" checksum="6946F0768D462A68" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHX7</accession>
    <name>D7VHX7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997824.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10596"/>
    <dbReference type="EnsemblBacteria" id="EFK59679">
        <property type="protein sequence ID" value="EFK59679"/>
        <property type="gene ID" value="HMPREF0766_10596"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032XIA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094580_0_0_10"/>
    <dbReference type="OrthoDB" id="1345380at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106970" evidence="2">
        <location>
            <begin position="25"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="254" mass="29098" checksum="DB36E8EC0855470B" modified="2010-10-05" version="1">MYKLTKYKFGFYLLILFLGFNIQASHSQTMSQVSGLVMEKGTGTRLSDVNVTNLRTRRVGITNNFGVFNIDASIGDSLYFSKIGYGSVKTILYSKDDILIDMQAGIKLETVIVERMTKEAEMNNIMRDYEKKGIYNGGKNKTMTYLASPATALYNLFGREAKNAKRFQGYMDREIEEAKVDRVFTRSTVTNITALQGEDLESFMSIYRPSPDMVQHWGQYDIMNYVKKSFEKFEKDGRPKPERLPKLAIPPQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI43</accession>
    <name>D7VI43_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 17" type="primary">dnaG</name>
        <name evidence="17" type="ORF">HMPREF0766_10662</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13 14">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the DnaG primase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997955.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10662"/>
    <dbReference type="EnsemblBacteria" id="EFK59745">
        <property type="protein sequence ID" value="EFK59745"/>
        <property type="gene ID" value="HMPREF0766_10662"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013501_3_0_10"/>
    <dbReference type="OrthoDB" id="1071997at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002811">
        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="16">
        <location>
            <begin position="282"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12 14">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="458"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002811-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFK59745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="683" mass="77540" checksum="C82A4E4604206597" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI66</accession>
    <name>D7VI66_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998001.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10685"/>
    <dbReference type="EnsemblBacteria" id="EFK59768">
        <property type="protein sequence ID" value="EFK59768"/>
        <property type="gene ID" value="HMPREF0766_10685"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_2_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107163" evidence="1">
        <location>
            <begin position="27"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="215"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1115" mass="125449" checksum="DA6B3B2C9A86D099" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIG7</accession>
    <name>D7VIG7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA ligase (ATP)</fullName>
            <ecNumber evidence="2">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">NHEJ DNA polymerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ligD</name>
        <name evidence="16" type="ORF">HMPREF0766_10786</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998201.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10786"/>
    <dbReference type="EnsemblBacteria" id="EFK59869">
        <property type="protein sequence ID" value="EFK59869"/>
        <property type="gene ID" value="HMPREF0766_10786"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008325_0_0_10"/>
    <dbReference type="OrthoDB" id="2061599at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014146">
        <property type="entry name" value="LigD_ligase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014143">
        <property type="entry name" value="NHEJ_ligase_prk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02777">
        <property type="entry name" value="LigD_PE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02779">
        <property type="entry name" value="NHEJ_ligase_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02776">
        <property type="entry name" value="NHEJ_ligase_prk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="15">
        <location>
            <begin position="315"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFK59869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="826" mass="94891" checksum="25AB75F7B76E016B" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VII6</accession>
    <name>D7VII6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998236.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10805"/>
    <dbReference type="EnsemblBacteria" id="EFK59888">
        <property type="protein sequence ID" value="EFK59888"/>
        <property type="gene ID" value="HMPREF0766_10805"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025928_1_0_10"/>
    <dbReference type="OrthoDB" id="319098at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041662">
        <property type="entry name" value="SusD-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12771">
        <property type="entry name" value="SusD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107181" evidence="1">
        <location>
            <begin position="21"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="503" mass="55800" checksum="81BE36BC5C6186DD" modified="2010-10-05" version="1">MKYNIIKITLLAFVSITLTACSDFLDVNVNPNSPIKENLSLNAKLPAALVTTAANEAIQLNQIGGLWGGYWGTSNEGVSSFTSLKTYNGPAIRDTRDGVPVWESNYNNLLYYKEILDQANTEDAKFYSGIAKIMMAYHFFILVDFYNNVPFDEALKGSAVLHPSYEPGKDVYTKSINLITEGIQEIKVASLLPTNDDVLFKGDKVKWAKFGNTLKLRALLRQSEVSAQATYITQEIAKIVQEGSGFLLENASVNPGYLNTATKMNPFYETFYRNNAGVAVANYANIRPTQYLISKYKEFNDPRLAQNYTSVAGDYKGVIFGNNTIANEFAAATTSAFKGPTENANQPAGIIKSFNQVSMIISLAEANFLQAEAVERGWISGVASQLYQSGIQASFNYLFNVNNYNIQTYINQNSVSYATATNKMERIITQKWLALNSINNIQAWNDFRRLGFPNFPNSVSSPTAGAHPLRFMYPETEVNTNNQNVVAQGENGVLTSKVWWDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIL6</accession>
    <name>D7VIL6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="6 7">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">murF</name>
        <name evidence="11" type="ORF">HMPREF0766_10835</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="6 7"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998296.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10835"/>
    <dbReference type="EnsemblBacteria" id="EFK59918">
        <property type="protein sequence ID" value="EFK59918"/>
        <property type="gene ID" value="HMPREF0766_10835"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031507_4_0_10"/>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="8">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="95"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="9">
        <location>
            <begin position="307"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="97"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK59918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="433" mass="47791" checksum="CAD3BE0E530996F3" modified="2010-10-05" version="1">MTIEALYDLYLQHPYVSTDTRNILPGSLFFALKGANFNGNSFADQALQTGASYVIIDEASYAKDGRYILVDNVLESLQKLANHHRKTLSIPVIGVTGTNGKTTTKELLHATLSQKFKTYATKGNLNNHIGVPLTLLSVDSTIQIAVIEMGANHLKEIAFLCDIAEPTHGLISNVGKAHLEGFGSFEGVKKTKGELYDYLQNHNGTLFLQADNPHLNEMAATRKISEVVTYGFAETNDVIGKLLKADPLLQIEWKEKDKPDSYTVHTQLTGSYNTENFLAAIAVGLYFGVSAEQINTGIERYTPKNNRSQVTKTEHNTIIADYYNANASSMAAALDNIEVIDASRKVIILGDMFEMGDESDAEHEKVVQRAKSIGADRLIFVGKAFKKQAYLEAEFYETSEEAKQALIDRPVINSTILLKASRGMAFEHLMDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIS6</accession>
    <name>D7VIS6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998424.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10895"/>
    <dbReference type="EnsemblBacteria" id="EFK59978">
        <property type="protein sequence ID" value="EFK59978"/>
        <property type="gene ID" value="HMPREF0766_10895"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033JQJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2025244_0_0_10"/>
    <dbReference type="OrthoDB" id="1968238at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025578">
        <property type="entry name" value="DUF4359"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14271">
        <property type="entry name" value="DUF4359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="123" mass="14367" checksum="4E547A2BEB1979F6" modified="2010-10-05" version="1">MKNKSRYIALVLIILMITAFLTNPPREKHEEIIRDKAKQILKEQLSYKHQDAFDFGMQIFGDQMINQFMKGSVQIDNYFLFSTTKVRWENKQTVIGIGAFGKVWLSSKIDEKIADIIKVLKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIV3</accession>
    <name>D7VIV3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">dnaN</name>
        <name evidence="13" type="ORF">HMPREF0766_10922</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta sliding clamp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998480.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10922"/>
    <dbReference type="EnsemblBacteria" id="EFK60005">
        <property type="protein sequence ID" value="EFK60005"/>
        <property type="gene ID" value="HMPREF0766_10922"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038149_4_1_10"/>
    <dbReference type="OrthoDB" id="1040142at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 9 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="10">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="11">
        <location>
            <begin position="130"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="12">
        <location>
            <begin position="246"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFK60005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="374" mass="41367" checksum="76E5474205169D28" modified="2010-10-05" version="1">MRFIVSTSILLKQLQAISGASSSSTVLPILENFLFEIKDNTLTISATDLQTSMVTSLQIESKEEGRVAMPSKILIETLKTLPDQPVAFSVDTNTLAIEISAGDGKYKLSGENADDFPKIPTVDNTSTVNIPAPVLAEAINKTIFAVSNDELRPAMSGVLVQLAEQSTTFVSTDAHKLVRYRRTDIYTDKPASLILPKKALSLLKSSLPSDDVNVTIEYNNTNAFFQFGNIFLICRLIDERYPDYEAVIPQVNPNKLTVDRSLFLNTLRRVVIFANKTTHQVRLRISGSELNISAEDLDFSNEAHERLSCQFEGDDMEIGFNAKFLVEMLNNLSSEEVIIEMSTPNRAGLLIPAIKDDNEDILMLVMPVMLNNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ41</accession>
    <name>D7VJ41_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DinB_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002155.1">
        <property type="nucleotide sequence ID" value="NZ_GL379779.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11010"/>
    <dbReference type="EnsemblBacteria" id="EFK59176">
        <property type="protein sequence ID" value="EFK59176"/>
        <property type="gene ID" value="HMPREF0766_11010"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032X65">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109379_2_0_10"/>
    <dbReference type="OrthoDB" id="1564766at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="24"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="167" mass="19660" checksum="415BC1D47FFDEA28" modified="2010-10-05" version="1">MNLNDQVTKNIVHIFEQFNHSLLTTDENQINTIPFEDSWTIGQTADHIIICSSGIPDEHTQVSERPFDRHVSVLKEMFLNMELKFKADPSLLPRKNSYTKDELLEQMEINKSNLLKNIESMDLTLICTDMAFPQIDYLTRYEWLSFIGFHTQRHLIQIENIKYKLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ91</accession>
    <name>D7VJ91_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR substrate binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000464.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11060"/>
    <dbReference type="EnsemblBacteria" id="EFK58944">
        <property type="protein sequence ID" value="EFK58944"/>
        <property type="gene ID" value="HMPREF0766_11060"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_1_10"/>
    <dbReference type="OrthoDB" id="750230at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="301" mass="34552" checksum="0F275C41E4A40C17" modified="2010-10-05" version="1">MEFDYRLKVFYVAANTLNFTKAATELFISQPAVSKNIQEIENTVGTPLFERLGNRLILTKAGSILYHHTQLIFEQYNQASYEINKIIGKGNGSLFIGISTTISQYVIPKILAQFVASCPQNDIKVYEYNSKRVEELLLRKEIHLGITEGLTDNRSLKFTPFLKDEIVLVTNTQNPLFNKEEFSLKDLYYIPLVIRETGSGTRDIIEERLRQKGIATHKLRIEITLSSTESIKEYLKYSKAAAFVSIHAISNELNTNQLRIIELTDLNIERNFYITHLHGGLTGLPETFLKYIQKHKNHIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ96</accession>
    <name>D7VJ96_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4240 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000479.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11065"/>
    <dbReference type="EnsemblBacteria" id="EFK58949">
        <property type="protein sequence ID" value="EFK58949"/>
        <property type="gene ID" value="HMPREF0766_11065"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032WTN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138388_0_0_10"/>
    <dbReference type="OrthoDB" id="1710926at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025334">
        <property type="entry name" value="DUF4240"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14024">
        <property type="entry name" value="DUF4240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4240" evidence="1">
        <location>
            <begin position="9"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="122" mass="13998" checksum="65FD87E9E68BBA4A" modified="2010-10-05" version="1">MKDAEISEWFWSLIKNANLNRDTLRGLLANFSKDDLIKFQEEFIDASVELQEAPFTDYMEESEDGVEDIANWIVSNGKAFYFHILNNPGEIPNNVNDFTDQILYGIADEVCVEKYGESTGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJB9</accession>
    <name>D7VJB9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000550.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11088"/>
    <dbReference type="EnsemblBacteria" id="EFK58972">
        <property type="protein sequence ID" value="EFK58972"/>
        <property type="gene ID" value="HMPREF0766_11088"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033HEZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_667142_0_0_10"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107566" evidence="1">
        <location>
            <begin position="18"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="410" mass="46972" checksum="5887A431E045FAEC" modified="2010-10-05" version="1">MWRNNFLALLCCALFFACTKSEDSFYAEDVPPLQAIIPKVDTPDFLLDIGKINIQVTANGNYAGSFESAFFKDISGTNHSYCHPDVQYFPNGFNGYKYWMVFTPYFGYVGTTQESKRYENPTVVVSNDGLNWVSPLGIISPLMRTPSARESFLENKQDPRQGFWSDVDWVYVNNKFYLYYRGSFITAQTFKNKCVKSKNNTDKLKTNAHRTIVQQTSVDGIRWTPLEIAYTSNAPYSPQNNHLLSPTMIHNGSRFMSYEVELNTGNKNFKGKELSYIVQRTSNDGLNFSLFKQSKIVNFVNMPWKKVDENYAPWHIQAAYVDGYYFLCLAVGNVKKYTADALYLAYSKDGINFVVLAKPMVEKNVYRSAIFPMKSDDEAIDFGAVIGFKSGEFKYREFKLNKQKLESALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJD7</accession>
    <name>D7VJD7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative FeS assembly SUF system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000593.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11106"/>
    <dbReference type="EnsemblBacteria" id="EFK58990">
        <property type="protein sequence ID" value="EFK58990"/>
        <property type="gene ID" value="HMPREF0766_11106"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091588_2_0_10"/>
    <dbReference type="OrthoDB" id="1668114at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="109" mass="12062" checksum="01DB28E243A71573" modified="2010-10-05" version="1">MSIIFLDRLNLGPEIQKVLETIYDPELKPANIVDLGLIYEVITKEDGTAKIVMTLTAPGCPVAGEIMDEVQRKVAGIEGVKEALVELTFDPPWTKDMMTEEAKLELGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJJ3</accession>
    <name>D7VJJ3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pantothenate synthetase</fullName>
            <shortName evidence="5">PS</shortName>
            <ecNumber evidence="5">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pantoate--beta-alanine ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pantoate-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">panC</name>
        <name evidence="6" type="ORF">HMPREF0766_11162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="5">The reaction proceeds by a bi uni uni bi ping pong mechanism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000682.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11162"/>
    <dbReference type="EnsemblBacteria" id="EFK59046">
        <property type="protein sequence ID" value="EFK59046"/>
        <property type="gene ID" value="HMPREF0766_11162"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047148_0_0_10"/>
    <dbReference type="OrthoDB" id="1661843at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PTHR21299:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="184"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK59046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="280" mass="31715" checksum="6D7F9E0624AA7DEE" modified="2010-10-05" version="1">MEIFKTKKELQDYLSAAREAKQKVALIPTMGALHEGHISLIEYAKPIADIRVCSIFVNPTQFNDPKDLEKYPRPIEHDIRMLESANCDILFMPSTAEMYGTNEEWHIDLGDLDSIWEGEHRPGHFQGVTQIVYKLFTLVQPDIACFGQKDFQQVMVINKMIKDKHLPIQLAICPIVRDKDGLALSSRNARLSEAGKKTALALSKALRHVRNQFTQTSPDQLKEEAIAILEQTAGVKVEYFAICETTTLHEAHTIEADKKYVALVTAWVEGVRLIDNMILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJP5</accession>
    <name>D7VJP5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-isopropylmalate dehydratase small subunit</fullName>
            <ecNumber evidence="10">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alpha-IPM isomerase</fullName>
            <shortName evidence="10">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">leuD</name>
        <name evidence="12" type="ORF">HMPREF0766_11214</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the LeuD family. LeuD type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="10"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000792.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11214"/>
    <dbReference type="EnsemblBacteria" id="EFK59098">
        <property type="protein sequence ID" value="EFK59098"/>
        <property type="gene ID" value="HMPREF0766_11214"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081378_0_3_10"/>
    <dbReference type="OrthoDB" id="1384217at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="11">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK59098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="194" mass="21976" checksum="B9527339F46FC21E" modified="2010-10-05" version="1">MKKFEKLNSTVVPLPIENIDTDQIIPARFLKATTREGFGNNLFRDWRFDSNNQPKADFVMNNPTYKGKILVAGKNFGCGSSREHAAWAIQDYGFDVVISSFFADIFKGNALNNGVLPIQVSDEFLETIFETVTKNPDTEVIVDLENQTVTLVENGAQTSFEINPYKKSCLINGYDDIDFILNQKELIEKYELSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJS8</accession>
    <name>D7VJS8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000892.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11247"/>
    <dbReference type="EnsemblBacteria" id="EFK59131">
        <property type="protein sequence ID" value="EFK59131"/>
        <property type="gene ID" value="HMPREF0766_11247"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_682891_0_0_10"/>
    <dbReference type="OrthoDB" id="783461at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="409" mass="46881" checksum="2B1B5AF30BF0033B" modified="2010-10-05" version="1">MPGKWFQISLFNFAIAAYMGLLLRYAGVYTIGNINFKFLLHGHSHGAMLGWIYLALTALIYDRFAEQSKQSEKYFKILFIVSQIAVIGMFIFFPVQGYAVYSIIFSTLHLLCSYTFVYLIWKFRKREHNPGSTLLKTALGFMLISTLGVWCLGPAVGLMGNTSAFFQVAIQFFLHFQFNGWFVIAVLAIAFYFFRIAFQAKDWKVFYILLLLSVVLTFALPLSWYLKNPLLYWVHAAGILTQLAAFVILYRSVRFQVHGILKTYSATERILFSYSGLTLFIKIIIPLLLLYPPMMEAVHYIRHLVVGFIHLLMLGTISGSLLLFAMRSGWLNISSYGIRFSSYLLIIGFTLTEILLLLQGLSIYMGWPLVPYYPFLLFGASIVLCVAVLLLFIFSFIPKRQYKESNVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJW2</accession>
    <name>D7VJW2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11281"/>
    <dbReference type="EnsemblBacteria" id="EFK58564">
        <property type="protein sequence ID" value="EFK58564"/>
        <property type="gene ID" value="HMPREF0766_11281"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044440_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="317" mass="35823" checksum="03D9481F509D924A" modified="2010-10-05" version="1">MLSRLILLFLFLCTFMVTWGQSSGMITIGGDITKFYPVTWKDGNFDQHKPTVLNLGRSNIHEGGLWKGSVMATIVYHVSNGGHESNFLDVKLGTSKNNSIYQSFIAGWADATLQGEVNEIVLWMRGNTNYYYNATASVVPVVYDGVQHAYPYVTAIGGKVFDIKSNEEDYVMRNGNTFSESLNVLSDQSSYFKGNVGLGKRNPAEKLEVNGNIRAKEIKVEAANWPDYVFEEDYQLTPLPEIEAFIKANKHLPEVPSAQKIAEEGLSVGEINKLMIRKIEELTLYLIEKDCIIKKQQQQLDMVLKRLDKIENYEKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJX1</accession>
    <name>D7VJX1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11290"/>
    <dbReference type="EnsemblBacteria" id="EFK58573">
        <property type="protein sequence ID" value="EFK58573"/>
        <property type="gene ID" value="HMPREF0766_11290"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2059935_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107034" evidence="1">
        <location>
            <begin position="24"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="119" mass="12869" checksum="8001AAB6DBFBD54B" modified="2010-10-05" version="1">MKSKIIKVTGIALSLLFTHMASAQQDYRVQIGLDAPAYGTNLLVNFGTYSGPWVRGYSISNHDGSASFIQLATTGDHYSDGTSTQRYSYIGGGFSREYMVFQPDGNIGVGTRTVENSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJZ4</accession>
    <name>D7VJZ4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAAX amino terminal protease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998773.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11313"/>
    <dbReference type="EnsemblBacteria" id="EFK58596">
        <property type="protein sequence ID" value="EFK58596"/>
        <property type="gene ID" value="HMPREF0766_11313"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1010962_0_0_10"/>
    <dbReference type="OrthoDB" id="1927619at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="261" mass="29093" checksum="D968B1899CBBEE75" modified="2010-10-05" version="1">MKKVSGYLKVIIFYLFTLLIFIGSSALTKQSSLPDLLSLITASIFTFILIYWFVRSDKSVLSKNGLGFDKKSVVRFVSGFGTGLIMVLLMAVITITFSNVTFTRSQTFNPNILVLHIPLFLFVALREELAFRTYMLWKLKTITGPVVAMIIVTVIFSIEHLFGGYSVVNAFVGSGLGAILFGFATLRTGNIALSIGIHFAWNLTHWLLGFKGNSGFLIETVQKGTEQQAETIAFIGYIAAMIMGICVIYLFFKPQNNREYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK00</accession>
    <name>D7VK00_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH LytTR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK58602">
        <property type="protein sequence ID" value="EFK58602"/>
        <property type="gene ID" value="HMPREF0766_11319"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2002453_0_0_10"/>
    <dbReference type="OrthoDB" id="1958442at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH LytTR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="124" mass="14453" checksum="BD59A520D8C3D97C" modified="2010-10-05" version="1">MYMTSIESLKYLIKERDVTLIISAADITHCVSMGAHTELVRRNEKGYVIKKNIKTVLEELSHPYFIRVSRSLVVNLQYLKCIHNREKQIELESGIRLEFSIAAFKLTQEVEHIFKNGSKTYSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK14</accession>
    <name>D7VK14_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma factor regulatory protein, FecR/PupR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11333</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998831.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11333"/>
    <dbReference type="EnsemblBacteria" id="EFK58616">
        <property type="protein sequence ID" value="EFK58616"/>
        <property type="gene ID" value="HMPREF0766_11333"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050192_1_0_10"/>
    <dbReference type="OrthoDB" id="1381035at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032508">
        <property type="entry name" value="FecR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16344">
        <property type="entry name" value="DUF4974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="163"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4974" evidence="3">
        <location>
            <begin position="296"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="366" mass="40572" checksum="0103C40D31247938" modified="2010-10-05" version="1">MNEDNLNKQAKKLLQKYLNGQCTPEEEQQVIEWFYSFGDELPSAEEDSTDSLKRSKTVILDQIQREEDTLTSSGFFTWKRMLVAAVILVVMGGLLGIYLKSNNTTQTVDLAAVIPDSSGQYKNDIMPGSSYAVITYPNGKRKTTVDSGTDQNLSSSAEKGLLTIEVPKAGKYKLTLNDGTNVWLNSSSVLSYPTVFDSDQRIVKLSGEAYFDVAKDTDRPFRIELNGSVIEVLGTSFNVNAYTDEISTSLVEGKVKIITGQKETFLSPGNEALIKGNDVAVAPADIQKNTAWQRDEFYFDSDNLSEIIKEVARWYDVEIVNAGSLTVNTTYKGAISREAKLSEVLNILSSATQRRFEIDGRKVIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK26</accession>
    <name>D7VK26_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998867.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11345"/>
    <dbReference type="EnsemblBacteria" id="EFK58628">
        <property type="protein sequence ID" value="EFK58628"/>
        <property type="gene ID" value="HMPREF0766_11345"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031B3Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1575646_0_0_10"/>
    <dbReference type="OrthoDB" id="1494637at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018914">
        <property type="entry name" value="DUF2480"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10652">
        <property type="entry name" value="DUF2480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="165" mass="18730" checksum="C030A6DF0E5980D1" modified="2010-10-05" version="1">MTAPLVNKVQQSGIIGLDLMDYAPQVSFVQLDIKDMLYMGMMLREKEFREKLQHLDFSLFAGKAVTIMCSSDAIVPQWAYMLLTTLLRPYAFSLSFGEQDHHYQSLWINAITAADFTKLKGRKVAVRNDIRVPEGIYMAVTSRLLPLVSGLMYGEVGMPKVIYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK76</accession>
    <name>D7VK76_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999000.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11395"/>
    <dbReference type="EnsemblBacteria" id="EFK58678">
        <property type="protein sequence ID" value="EFK58678"/>
        <property type="gene ID" value="HMPREF0766_11395"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4818">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095018_2_1_10"/>
    <dbReference type="OrthoDB" id="2012653at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="106" mass="11635" checksum="D5A66F43AE89AB50" modified="2010-10-05" version="1">MDNKTISILSYITLIGWLIAYFSGKEKADDSAKYHLKQGLGLIVFSFALSIVLQIVMSITHIYALSYISVISLVLLIIGAINASNGAKKPLPFIGSFFENKFAFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKE0</accession>
    <name>D7VKE0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3347 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999163.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11459"/>
    <dbReference type="EnsemblBacteria" id="EFK58742">
        <property type="protein sequence ID" value="EFK58742"/>
        <property type="gene ID" value="HMPREF0766_11459"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082412_0_0_10"/>
    <dbReference type="OrthoDB" id="1905459at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021782">
        <property type="entry name" value="DUF3347"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11827">
        <property type="entry name" value="DUF3347"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107240" description="DUF3347 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3347" evidence="3">
        <location>
            <begin position="156"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="292" mass="32445" checksum="D63134FF4CD88E83" modified="2010-10-05" version="1">MKSFKNILSLILLSGIAATPVLAAAQIKNAKTESIRIEGNSEACKTLIEKAGSKKGEAELDWNTDTKKAELTYNSQKTSKDEILKRIALAGFDNEMYLAPTDVYQALSPECQYKGTIKTAKRADHASKEMDHSKMDHSTTEGTNEHTAKESKLESLYKNYFTIKDAFIKGDSKAVTAGAANLKTAIAAIKMGELQPKEHDVWMMVMKDLEKQTAALHSSKGLEKQRVVFMSLSEQIYKLIKATDPAYTVYYNHCPMFNDGKGANWLSKEKSIQNPYYGSQMLTCGSTKETIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKF2</accession>
    <name>D7VKF2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA large subunit methyltransferase F</fullName>
            <ecNumber evidence="2">2.1.1.181</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">23S rRNA mA1618 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">rRNA adenine N-6-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rlmF</name>
        <name evidence="3" type="ORF">HMPREF0766_11471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the adenine in position 1618 of 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16497"/>
            <dbReference type="Rhea" id="RHEA-COMP:10229"/>
            <dbReference type="Rhea" id="RHEA-COMP:10231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.181"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. METTL16/RlmF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.181" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999202.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11471"/>
    <dbReference type="EnsemblBacteria" id="EFK58754">
        <property type="protein sequence ID" value="EFK58754"/>
        <property type="gene ID" value="HMPREF0766_11471"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027534_3_0_10"/>
    <dbReference type="OrthoDB" id="1027015at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052907">
        <property type="term" value="F:23S rRNA (adenine(1618)-N(6))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01848">
        <property type="entry name" value="23SrRNA_methyltr_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016909">
        <property type="entry name" value="rRNA_lsu_MeTfrase_F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="PTHR13393"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029038">
        <property type="entry name" value="Mtase_YbiN_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="304" mass="34609" checksum="D6477357F6EE143A" modified="2010-10-05" version="1">MKPSPKEIKKTLHSRNKHISGYDFQRLTKKNPALSGFLITNPAGQVTIDFADPKAVFELNKTLLLLHYDLQHWEIGKNSLCPPIPGRADYIHYVADLLAKDHNGNIPRGPQVKVLDIGTGSSLIYPIIGHQEYKWSFVGTDIDAQSLHHAYMNSSKNEALKKSIVLREQKDKAHVFTGVILPGEKYDLVLCNPPFYGSREENWKSTTKKFQNVNKNKEALPVQNFGGNANELWYEGGEKAFIRKMIYESMDYQAQLGWCTTLVANKDNLKPLVAVLEFKKAKDIEIIKMEQGNKISRILAWRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKP0</accession>
    <name>D7VKP0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999416.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11559"/>
    <dbReference type="EnsemblBacteria" id="EFK58842">
        <property type="protein sequence ID" value="EFK58842"/>
        <property type="gene ID" value="HMPREF0766_11559"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056607_3_1_10"/>
    <dbReference type="OrthoDB" id="1777515at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="150" mass="17463" checksum="F3363874BA1C2E70" modified="2010-10-05" version="1">MTTVWFYKTFDALSTNQLYQILKLRNEVFVVEQNCPYLDCDNKDQKCDHLWAMINNDIAAYARIVPAGVSFKEVSIGRVLSNPAYRKQKIGRELMRRAVDNIMDQYGAVDIRIGAQLYLKAFYESFGFQQASEEYLEDGIPHIEMLRKPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKV2</accession>
    <name>D7VKV2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transglycosylase SLT domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999527.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11621"/>
    <dbReference type="EnsemblBacteria" id="EFK58904">
        <property type="protein sequence ID" value="EFK58904"/>
        <property type="gene ID" value="HMPREF0766_11621"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009520_1_1_10"/>
    <dbReference type="OrthoDB" id="1444566at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107625" evidence="1">
        <location>
            <begin position="20"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="2">
        <location>
            <begin position="124"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="276" mass="31237" checksum="E245DC2912552259" modified="2010-10-05" version="1">MIKKKVLCCGLILAGMLLSKLYSSTKENAVAANVRYDDAKTLNIKNRIVNKAALSDHNGDKDNEGEHDYLISITFAEESLPLDLPQVERKLTQYLSRFSFRKQQTYSLHKQAEKHLPQIAAILKSHGIPEDFKYIPLVESGMDSRVVSSKGAGGYWQFMPATARLYGLKVSGKVDERLNLTKSTHAAARYLKYLYREFGDWTLVAAAYNVGGGSLRGAIRRQKQDDYYKLKLNNETASYVYKLVSVKEIIENPSKHGYTRYAKAPVADEEREKNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL47</accession>
    <name>D7VL47_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999764.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11716"/>
    <dbReference type="EnsemblBacteria" id="EFK58320">
        <property type="protein sequence ID" value="EFK58320"/>
        <property type="gene ID" value="HMPREF0766_11716"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_18_13_10"/>
    <dbReference type="OrthoDB" id="1360387at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="160"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="224" mass="24611" checksum="0C23434B8ECD04D1" modified="2010-10-05" version="1">MNHFLLFFSIIFLNACEADMKTETSSQLQTSIVEAVKANQLAEVESLLKNGADVNSKDKNAKSLLLIATQSRYIEMARLLVNNGADVNLQDDIFDSPFLYAGAAGYTELVQLFLEHGARFDIYNRYHGTALIPACERGHLDVVKLLSGTPKFPINHINRLGWTALMEAIVLGNGSEVYVEIVNTLVKAGCDINIPDKDNVTALEHAKARGYTAIAQVLENAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL48</accession>
    <name>D7VL48_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999767.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11717"/>
    <dbReference type="EnsemblBacteria" id="EFK58321">
        <property type="protein sequence ID" value="EFK58321"/>
        <property type="gene ID" value="HMPREF0766_11717"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114536_0_0_10"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="183" mass="21413" checksum="46D3F1A7634BDDF1" modified="2010-10-05" version="1">MKFEAYLAYFEDILHNPAAHAAYQDEEYFHYTKMNWSRMSRWLKKFEPSVEAKAFFGTITTKQHWILITEPWCGDAAHSVPMIYKMVKDNPNIELDIQLRDTAPFLIEQYLTNGGKSVPKLIIRNEAGEDLAVWGPRPDGCTAVFMQMKTKGAEFEEIKEEIQKWYNQDKGEEIQRELIKLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL58</accession>
    <name>D7VL58_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
            <ecNumber evidence="3">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cah</name>
        <name evidence="6" type="ORF">HMPREF0766_11727</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999786.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11727"/>
    <dbReference type="EnsemblBacteria" id="EFK58331">
        <property type="protein sequence ID" value="EFK58331"/>
        <property type="gene ID" value="HMPREF0766_11727"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0288">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053879_3_1_10"/>
    <dbReference type="OrthoDB" id="1841447at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="215" mass="23962" checksum="C92C600F6236A862" modified="2010-10-05" version="1">MENKDLKLGFDKILDGNKEWMDFVKNDTSGRFQQLAKGQNPEILWIGCADSRVPANELTGTKPGEVFVHRNIANVCVHSDMNMLSVLDYAVNVLKVKHVIVAGHYGCGGVAASLSRKQFGVIDNWLCHIKDVYRLHAAEIDSIQDPEQKTNRLVELNVVEQVFNLCTTSIVQNAWKERDDLAVHGMVINIGSGELIDLDTTFTNNESLGKVFAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL86</accession>
    <name>D7VL86_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999876.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11755"/>
    <dbReference type="EnsemblBacteria" id="EFK58359">
        <property type="protein sequence ID" value="EFK58359"/>
        <property type="gene ID" value="HMPREF0766_11755"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_3_1_10"/>
    <dbReference type="OrthoDB" id="554994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="94"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="339"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="468" mass="52019" checksum="A9D0A3894014A11C" modified="2010-10-05" version="1">MKKVNYILFGALIIGSLFSSCEKQVFEDPYAYLPPESAFSTPERIEKTATGMYDALQNREFLGGRVLIYADIRGIDGGVPTFFTNVPNFGNLNSNDLTVERAFVGAYRTIYEANLFLKNIEKYAGVATPQNEAKYKAEAKFIRALTYFYVVNLWAQPYKFTADGSHLGVPLVLTATDLPFDPANRVSRSTVKQVYDQIILDLTEALPSLPDVNPTTRDFGSVARANKNAVNALLARIYLYQQDYPKALEFANKVITTNNYTLNASPKTTFTEFTTKESIFSVAHNGSDNPNTNNALAQHYAPNLRADIQASSELVNLMKPEDLRRKDLITIAQGSFWNAKYTNIGDWAPILRYSEVLLTKAEALANIATGTTVDAEALALVNQIRHRSDPSTTIVAANKAALISAILTERRIELAFEGHGIFEFLRTGRDIPAHGTVPLQAWGSPRVVFPFPFAETQQNPNLVQNQDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLH5</accession>
    <name>D7VLH5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000135.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11845"/>
    <dbReference type="EnsemblBacteria" id="EFK58448">
        <property type="protein sequence ID" value="EFK58448"/>
        <property type="gene ID" value="HMPREF0766_11845"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_12_2_10"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="180" mass="21087" checksum="A5AEEB2CAF3D2B23" modified="2010-10-05" version="1">MKDNAMSRKERIMKEALALFAEKGYADTSTKIIAQNAEVSEALIFKHFGNKDALLFHLIKSGYRRVLMYHKGMMTYKNPKDFLKNMIFLPSKLVAEEPIFWKLQERLSHNSFSRQQHEQFMKPVQPIINRAFEELGYENPELETQFLLIVIDSLWKKEASGEIDQSLDLAILLEKKYDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLZ0</accession>
    <name>D7VLZ0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable GTP-binding protein EngB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ysxC</name>
        <name evidence="8" type="synonym">engB</name>
        <name evidence="10" type="ORF">HMPREF0766_11987</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for normal cell division and for the maintenance of normal septation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK57995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001127.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11987"/>
    <dbReference type="EnsemblBacteria" id="EFK57995">
        <property type="protein sequence ID" value="EFK57995"/>
        <property type="gene ID" value="HMPREF0766_11987"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0218">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033732_3_0_10"/>
    <dbReference type="OrthoDB" id="1746051at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0717">Septation</keyword>
    <feature type="domain" description="EngB-type G" evidence="9">
        <location>
            <begin position="22"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK57995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="207" mass="23735" checksum="DDFBFE5317F9FA8A" modified="2010-10-05" version="1">MLVKKAEFVCSNTRVDKLPDPTLPEYAFIGRSNVGKSSLINAMTNKKGLAKTSQKPGKTQLINHFIINDEWFLVDLPGYGFAQTSKTNRSEWQKFIRRYLTHRDNLQCVFVLIDSRHEPQKIDLDFCCWLGECGLPFMLIFTKADKQSAVKSDVNIAKFRKSLLQWFEEVPPHFLTSAETKTGCEPILEMINDINTRFVPPEAEGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM60</accession>
    <name>D7VM60_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cof-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001331.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12057"/>
    <dbReference type="EnsemblBacteria" id="EFK58065">
        <property type="protein sequence ID" value="EFK58065"/>
        <property type="gene ID" value="HMPREF0766_12057"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_7_0_10"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="259" mass="29308" checksum="C69B35E3DA3C502C" modified="2010-10-05" version="1">MIKAVFFDIDGTLLSFKTHLVPESTEKAIRELQSRGIKVIISTGRSINSLDHIRYLNFDGFITFNGGYCVTKDDEVLFRKPIPQEDIESLLNYAMNNEPVSFSLMSENEISIFHVTPDIQKMYDQLNLPVPMQRNYDNFDKATVLQTNIFIQPEAEEDFMRTIMPNSIASRWTPLFADVNPVGQSKKVGIDVFVQHFGLELHETMSFGDGGNDITMLAHTHIGVAMGNANPEVKAIADYITDDVDNNGIWNALKHYEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMG7</accession>
    <name>D7VMG7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001521.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12164"/>
    <dbReference type="EnsemblBacteria" id="EFK58172">
        <property type="protein sequence ID" value="EFK58172"/>
        <property type="gene ID" value="HMPREF0766_12164"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030WNS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129833_0_0_10"/>
    <dbReference type="OrthoDB" id="1975897at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107434" evidence="1">
        <location>
            <begin position="19"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="165" mass="19438" checksum="C5AD9EBD67883ADE" modified="2010-10-05" version="1">MHKLILIALLIIAKSAYAQKMNLDQMRKDFNKGVKNEELCKSHLEVLKKNAKSPEELGYYAAYHMFMANHTGNPFKKMSYFKGGRKILEDVIKKNPQNIELRFIRLCIQFYIPKFLNYHDNIETDKDFVMNNLYKMKDNDVKLLIFNYLKGANMYTSEELALLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMR1</accession>
    <name>D7VMR1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992750.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12281"/>
    <dbReference type="EnsemblBacteria" id="EFK57208">
        <property type="protein sequence ID" value="EFK57208"/>
        <property type="gene ID" value="HMPREF0766_12281"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012729_0_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107131" evidence="2">
        <location>
            <begin position="19"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="896" mass="103097" checksum="9480DB6EB2A68633" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN10</accession>
    <name>D7VN10_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="5">1.2.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gabD</name>
        <name evidence="5" type="ORF">HMPREF0766_12380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992904.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12380"/>
    <dbReference type="EnsemblBacteria" id="EFK57307">
        <property type="protein sequence ID" value="EFK57307"/>
        <property type="gene ID" value="HMPREF0766_12380"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_5_1_10"/>
    <dbReference type="OrthoDB" id="384611at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009013">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="19"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="476" mass="51138" checksum="85D498C25B14E1C5" modified="2010-10-05" version="1">MKNSLLINKAYINGKFVSGTKTFDVINPATGKVIDALPDLSVKECTKAIVAAEKAWLSWRDVPSGERSALIRKWYELILENKKALAEIMTLESGKPLQESLTEVDYGNSFVEWFAEEAKRAYGETIPSSKKGMHLMTIKQGIGVVAAITPWNFPLAMVTRKVAPALAAGCTVILKPASQTPFTAIAIAKLAEEAGLPKGVINVITGKDSAGIGKELATHKSIRKLSFTGSTEVGKTLMEQSASNIKKLSMELGGNAPFIVFDDADIDAAVQGAIAAKFRNSGQTCVSVNRFYVQDSVYDTFSKKLTQAVKGLKVGNGLDKGVQVGPLINAKGLEKVELHVADATKRGAKIAAGGKHIDGLFFEPTVLTHVPTDALIAHEETFGPVCALFRFTTEEEAITLANDTEFGLASYFYSQQLNRCLRVAERLEAGMVGINVGLISNAAAPFGGVKESGVGREGSRYGLDEYMEIKYLCFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN53</accession>
    <name>D7VN53_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4468 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992962.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12423"/>
    <dbReference type="EnsemblBacteria" id="EFK57350">
        <property type="protein sequence ID" value="EFK57350"/>
        <property type="gene ID" value="HMPREF0766_12423"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033IV7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1440227_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027823">
        <property type="entry name" value="DUF4468"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14730">
        <property type="entry name" value="DUF4468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4468" evidence="1">
        <location>
            <begin position="42"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="188" mass="21229" checksum="3838374FE5728383" modified="2010-10-05" version="1">MRKYLLTFFVIGAFSKLATGQELKLIQSGFADVKENSKNFIVIDAPGKAKNDLYNSTLKFISSTYNNPKFVTTKIDGEQIIIDAVGQGVSKRTMRLSESNVWDLNYKLIIDFKDSKIRVEPIFKNYENLEGSNVILSGKKILGNVFGLFNDKGKPNSDKAIKDAEAFINDIIKRYADNIKVSKDNNDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN69</accession>
    <name>D7VN69_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992982.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12439"/>
    <dbReference type="EnsemblBacteria" id="EFK57366">
        <property type="protein sequence ID" value="EFK57366"/>
        <property type="gene ID" value="HMPREF0766_12439"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50339JJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_375016_0_0_10"/>
    <dbReference type="OrthoDB" id="2089798at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="740" mass="77411" checksum="3E56255009F9330D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNB8</accession>
    <name>D7VNB8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12488"/>
    <dbReference type="EnsemblBacteria" id="EFK57415">
        <property type="protein sequence ID" value="EFK57415"/>
        <property type="gene ID" value="HMPREF0766_12488"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3084851_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="52" mass="5381" checksum="3EDB1F53760A8534" modified="2010-10-05" version="1">MLSFFIALLLGLISPSGTPTTHNNNGTATTYNSVDDPDDGDTGGDTGQVRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNK6</accession>
    <name>D7VNK6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993158.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12576"/>
    <dbReference type="EnsemblBacteria" id="EFK57503">
        <property type="protein sequence ID" value="EFK57503"/>
        <property type="gene ID" value="HMPREF0766_12576"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_15_10"/>
    <dbReference type="OrthoDB" id="1667813at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="127" mass="14060" checksum="5B0CB6542120B0E8" modified="2010-10-05" version="1">MKTGTVQETISLSFINDKSPVTDNICKDLAASGMEILSRSESIENGLTQLSSLNELPKVCIIDLDFYDQNVLKQLQELRKEYPAIKLVAHSDIDDEKVGKSLLEIGFSSYLLLGSDVDDFKKAIFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNP3</accession>
    <name>D7VNP3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3347 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993213.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12613"/>
    <dbReference type="EnsemblBacteria" id="EFK57540">
        <property type="protein sequence ID" value="EFK57540"/>
        <property type="gene ID" value="HMPREF0766_12613"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101306_1_0_10"/>
    <dbReference type="OrthoDB" id="1905459at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021782">
        <property type="entry name" value="DUF3347"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11827">
        <property type="entry name" value="DUF3347"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3347" evidence="1">
        <location>
            <begin position="44"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="180" mass="19995" checksum="05C1E61006E76032" modified="2010-10-05" version="1">MVITVLLSAANSFAQNQNEQHHNHGGTAQAKNIPSQNLSQLHAVFDKYFSIKDALVNADVNIASSNATELATVIKTVDMGELSPKEHTVWMKVMKELSLNTENISKSKDVVKQRRAFALLSKNVYELANASKQKTTMYYQNCPMYNDGKGATWLSKSTDIKNPYYGSKMLTCGSTIEKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNQ2</accession>
    <name>D7VNQ2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_12622</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12622"/>
    <dbReference type="EnsemblBacteria" id="EFK57549">
        <property type="protein sequence ID" value="EFK57549"/>
        <property type="gene ID" value="HMPREF0766_12622"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036805_12_5_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK57549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="110" mass="12652" checksum="40B959CE94B37C18" modified="2010-10-05" version="1">MSIKESDFDFESMKDLALEQLRSGESLYGKNGAFAPLMKKFLEAALEAEIESHLDEAERSCGNRRNGKSSKQIRTSDGTIEIDTPRDRRSNFEPQLIKKRETILAFFDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNS2</accession>
    <name>D7VNS2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993259.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12642"/>
    <dbReference type="EnsemblBacteria" id="EFK57569">
        <property type="protein sequence ID" value="EFK57569"/>
        <property type="gene ID" value="HMPREF0766_12642"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50345JJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_207716_0_0_10"/>
    <dbReference type="OrthoDB" id="2030104at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="59" mass="6245" checksum="C3DF6CDC6ACEBDFA" modified="2010-10-05" version="1">MPVPKIQQRPSSLPAQRRNPKNQNIQKVARANPVKNAKVTNAGAVVPTALAGAVLQPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNT3</accession>
    <name>D7VNT3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993276.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12653"/>
    <dbReference type="EnsemblBacteria" id="EFK57580">
        <property type="protein sequence ID" value="EFK57580"/>
        <property type="gene ID" value="HMPREF0766_12653"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147365_0_0_10"/>
    <dbReference type="OrthoDB" id="2004783at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="138" mass="15793" checksum="B26A48D792AD9B8B" modified="2010-10-05" version="1">MEKEKETVYLEGKNHMGIKIGSARRLVGITQKDLAERMGVTKQAVSKLEQTENVDDERLEKVAIALGVSVEGLKKFDVGQVLYHTNNFYEKVEPTNGAMVGTVRIENNHQFSIEQATKLFEELLRMEREHFQKAKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP56</accession>
    <name>D7VP56_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993478.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12776"/>
    <dbReference type="EnsemblBacteria" id="EFK57703">
        <property type="protein sequence ID" value="EFK57703"/>
        <property type="gene ID" value="HMPREF0766_12776"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1275789_0_0_10"/>
    <dbReference type="OrthoDB" id="1294292at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="207" mass="24412" checksum="EBA3F36ACB9EBFCD" modified="2010-10-05" version="1">MPDYTKQLQKYMPELAAPIISQWIIDSKCSFKISRARATKLGDYQAPYRGESHKISVNNNLNPYSFLITTIHEFAHLRTWQQHKNKVKPHGTEWKDNFKFLMEPFLKLHIFPEKILHAVIKYLNNPAASSCTDLHLFRTLKEYDSAQSPVITVEMLNQDDLFSMKNGRVFQRKERIRKRYRCVEVSTNRIYLFHPVAEIYPIPDPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP83</accession>
    <name>D7VP83_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993531.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12803"/>
    <dbReference type="EnsemblBacteria" id="EFK57730">
        <property type="protein sequence ID" value="EFK57730"/>
        <property type="gene ID" value="HMPREF0766_12803"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3047">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100971_0_0_10"/>
    <dbReference type="OrthoDB" id="2018542at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107484" description="OMP_b-brl domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl" evidence="2">
        <location>
            <begin position="8"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="211" mass="22987" checksum="DEE2E884A541CB6C" modified="2010-10-05" version="1">MKKILLTIAAVAGLTFASQAQEFGFKKTDFIVEGYFQSSNKNDKSKDEKVSNFNFNPKFGYFVTDKIAVGLELGVGNSKTTKTTNDVESYTKNNAFGIGAFGRYYFLEVGSRFKTYAELGAGYSQIGGELNNGTTTTKLDKTKGFGINAGVGANYFLTNSIAVSFAFADVVSFNSSKVDVDGAKSTTNFNTNINVFDNFFNTAKFGLTYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPM6</accession>
    <name>D7VPM6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12946"/>
    <dbReference type="EnsemblBacteria" id="EFK57873">
        <property type="protein sequence ID" value="EFK57873"/>
        <property type="gene ID" value="HMPREF0766_12946"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3258022_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="42" mass="5219" checksum="65578F1B8496626B" modified="2010-10-05" version="1">MAFLLIVFHLNIYNIDIFLIKIEKCYEICFLILYFVTQYKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPS2</accession>
    <name>D7VPS2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0766_12992</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993872.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12992"/>
    <dbReference type="EnsemblBacteria" id="EFK57919">
        <property type="protein sequence ID" value="EFK57919"/>
        <property type="gene ID" value="HMPREF0766_12992"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_2_0_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07660">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0798">TonB box</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107213" evidence="7">
        <location>
            <begin position="26"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="domain" description="STN" evidence="9">
        <location>
            <begin position="53"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="10">
        <location>
            <begin position="216"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="8">
        <location>
            <begin position="504"/>
            <end position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK57919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1099" mass="121200" checksum="0C92A877D66E5C8E" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPW0</accession>
    <name>D7VPW0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Conserved repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_13030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intimin/invasin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13030"/>
    <dbReference type="EnsemblBacteria" id="EFK57957">
        <property type="protein sequence ID" value="EFK57957"/>
        <property type="gene ID" value="HMPREF0766_13030"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_224773_0_0_10"/>
    <dbReference type="OrthoDB" id="38593at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003344">
        <property type="entry name" value="Big_1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044023">
        <property type="entry name" value="Ig_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015217">
        <property type="entry name" value="Invasin_dom_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02369">
        <property type="entry name" value="Big_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01345">
        <property type="entry name" value="DUF11"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19081">
        <property type="entry name" value="Ig_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09134">
        <property type="entry name" value="Invasin_D3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00634">
        <property type="entry name" value="BID_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01451">
        <property type="entry name" value="B_ant_repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51127">
        <property type="entry name" value="BIG1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="2159"/>
            <end position="2220"/>
        </location>
    </feature>
    <feature type="domain" description="Big-1" evidence="4">
        <location>
            <begin position="2926"/>
            <end position="3021"/>
        </location>
    </feature>
    <feature type="domain" description="Big-1" evidence="4">
        <location>
            <begin position="3029"/>
            <end position="3124"/>
        </location>
    </feature>
    <feature type="domain" description="Big-1" evidence="4">
        <location>
            <begin position="3132"/>
            <end position="3227"/>
        </location>
    </feature>
    <feature type="domain" description="Big-1" evidence="4">
        <location>
            <begin position="3235"/>
            <end position="3330"/>
        </location>
    </feature>
    <feature type="domain" description="Big-1" evidence="4">
        <location>
            <begin position="3338"/>
            <end position="3433"/>
        </location>
    </feature>
    <feature type="domain" description="Big-1" evidence="4">
        <location>
            <begin position="3441"/>
            <end position="3516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1608"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1746"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="3516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="3516" mass="364082" checksum="3E496BDFB40D6B89" modified="2010-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPW8</accession>
    <name>D7VPW8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57125">
        <property type="protein sequence ID" value="EFK57125"/>
        <property type="gene ID" value="HMPREF0766_14328"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3103967_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="51" mass="6113" checksum="311D15EA8F30BB1B" modified="2010-10-05" version="1">MLHFAFIFYSKFLHHTDAVNDTVTTYRRQMRLFELKEITKAVIHGNSQEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPY5</accession>
    <name>D7VPY5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13039"/>
    <dbReference type="EnsemblBacteria" id="EFK55836">
        <property type="protein sequence ID" value="EFK55836"/>
        <property type="gene ID" value="HMPREF0766_13039"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_232715_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026341">
        <property type="entry name" value="Bac_Flav_CTERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012569">
        <property type="entry name" value="LRR-contain_adjacent_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01345">
        <property type="entry name" value="DUF11"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08191">
        <property type="entry name" value="LRR_adjacent"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01451">
        <property type="entry name" value="B_ant_repeat"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04131">
        <property type="entry name" value="Bac_Flav_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF11" evidence="2">
        <location>
            <begin position="482"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="2">
        <location>
            <begin position="649"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="LRR_adjacent" evidence="3">
        <location>
            <begin position="691"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="2">
        <location>
            <begin position="772"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="LRR_adjacent" evidence="3">
        <location>
            <begin position="813"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="2">
        <location>
            <begin position="897"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="LRR_adjacent" evidence="3">
        <location>
            <begin position="936"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1221"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1354"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1391"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1428"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1524"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1356"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1402"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1532"/>
            <end position="1546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK55836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="2078" mass="219292" checksum="A2833EE4CAC7A804" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPZ0</accession>
    <name>D7VPZ0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993955.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13044"/>
    <dbReference type="EnsemblBacteria" id="EFK55841">
        <property type="protein sequence ID" value="EFK55841"/>
        <property type="gene ID" value="HMPREF0766_13044"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_270304_0_0_10"/>
    <dbReference type="OrthoDB" id="161002at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01345">
        <property type="entry name" value="DUF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF11" evidence="1">
        <location>
            <begin position="530"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1206" mass="133950" checksum="EE224B52B26A4C51" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ03</accession>
    <name>D7VQ03_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_13057</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993973.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13057"/>
    <dbReference type="EnsemblBacteria" id="EFK55854">
        <property type="protein sequence ID" value="EFK55854"/>
        <property type="gene ID" value="HMPREF0766_13057"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_8_2_10"/>
    <dbReference type="OrthoDB" id="1194802at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004705">
        <property type="entry name" value="Cation/H_exchanger_CPA1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00831">
        <property type="entry name" value="a_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 6" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="11"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK55854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="525" mass="58854" checksum="0178696F78F956BD" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ09</accession>
    <name>D7VQ09_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter, auxin efflux carrier (AEC) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_13063</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993980.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13063"/>
    <dbReference type="EnsemblBacteria" id="EFK55860">
        <property type="protein sequence ID" value="EFK55860"/>
        <property type="gene ID" value="HMPREF0766_13063"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056175_5_0_10"/>
    <dbReference type="OrthoDB" id="2033473at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK55860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="305" mass="33956" checksum="13D12C693408BFBB" modified="2010-10-05" version="1">MANFILIIICIAAGYILKQTKSIHPDAHKGINTWILYFALPAVSFKYLPHIDWNRDLIVPVMSPLVVLLGSMIFFRIYCWRKHYSARTESTLTMVSGFSNTSFVGFPLVAAFYGEEYMSIAIICDQATFFLLSTLGVYLATKGSVDSAAKLNLGYIIRRLFTFPPFLGCIAALILPRFIDLTAIEPVFDKLGATVSPLALFSVGLQLQFKGWKKQISQISFSLFYKLLIAPALVLIFVLLTGAKKEIGAVTIFEMAMPTLVSTSIVIEQFRLNSKIANIIIGFSIIIALLTAGIWSAVIHYFLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ21</accession>
    <name>D7VQ21_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_13075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993994.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13075"/>
    <dbReference type="EnsemblBacteria" id="EFK55872">
        <property type="protein sequence ID" value="EFK55872"/>
        <property type="gene ID" value="HMPREF0766_13075"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_40_3_10"/>
    <dbReference type="OrthoDB" id="1570162at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK55872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="213" mass="24858" checksum="A11F60F17B8FE14D" modified="2010-10-05" version="1">MGIKERKEKHKEDLRQRILDAAKELFLKHGYEATSIRKIAEKIEFSPTTIYLYYKDKTDIMYALHQEGFKLLGTQFMVLQYVHEPFERLKAMGRVYMSFALNNPDFYELMFIQKEPLEFVKNNCVDEGWEEGEQSFNALIRTVEDCQSAGYFTQFDANTFALNVWSLMHGLCSLKLQGHLDHVASVKLAVAEGENVMDQTYEGFIRVLESLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQA4</accession>
    <name>D7VQA4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ThuA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994133.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13158"/>
    <dbReference type="EnsemblBacteria" id="EFK55955">
        <property type="protein sequence ID" value="EFK55955"/>
        <property type="gene ID" value="HMPREF0766_13158"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3828">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057383_1_2_10"/>
    <dbReference type="OrthoDB" id="1452706at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThuA" evidence="1">
        <location>
            <begin position="26"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="240" mass="27545" checksum="30530A220E64F529" modified="2010-10-05" version="1">MRKIITLFIIYVACAHIAFAQSGEKRILIFSKTAAFRHKSIEHGADVLKDLLAKNHMLSEHSEDAGVFSDDQLAKYDAVLFLSTTGDIFNDSQKEAFQKFIRSGKGFVGIHAASDTEYHWPWYGQMVGGYFVSHPAVQEALIHVLNRKHPSTKHLPKEWKHKDEWYDFRDIQPDNKVLMKVDETSYKGGKMNGNHPIAWYKEFEGGRIFYTGLGHTEEAFDEPDFQQHVLGGLRYVLKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQF8</accession>
    <name>D7VQF8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_13212</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Skp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13212"/>
    <dbReference type="EnsemblBacteria" id="EFK56009">
        <property type="protein sequence ID" value="EFK56009"/>
        <property type="gene ID" value="HMPREF0766_13212"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053320_2_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.910.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005632">
        <property type="entry name" value="Chaperone_Skp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024930">
        <property type="entry name" value="Skp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35089">
        <property type="entry name" value="PTHR35089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03938">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00935">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111384">
        <property type="entry name" value="SSF111384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="169" mass="19708" checksum="157F95CC994EA1DA" modified="2010-10-05" version="1">MKSVFALWVCMALCVISVVYVLFLKSDKIGYIESTRIFQEYKGAKVEREKLEEKTKEFKSKLDTLNQEVREAIIRYDGQSAVKKDNQSEQIIQLKQRQLEEYRRMIQENIQSEEANAMNKIAAELNVFLKDYGKRNNYKFIFIANPSGTIAYAEEGTDLTEDVLKELNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQH5</accession>
    <name>D7VQH5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13229"/>
    <dbReference type="EnsemblBacteria" id="EFK56026">
        <property type="protein sequence ID" value="EFK56026"/>
        <property type="gene ID" value="HMPREF0766_13229"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032YX9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126586_0_0_10"/>
    <dbReference type="OrthoDB" id="1866745at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107529" evidence="1">
        <location>
            <begin position="31"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="157" mass="17344" checksum="0FD5317AB7DB8417" modified="2010-10-05" version="1">MKNNSMRRSILKGILILTSGILLVSCQSSGRSESTKDSITNADSNPVPVTYSYQNNGDTIVLQLTNLEGKVTGELAYQIKEKDRNTGSIEGVLTDSLLLADYTFQSEGTTSVRQVAFKFKGDTVIEGYGDIEERDGKMVFKEPEKLHFIAEMPLVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQM9</accession>
    <name>D7VQM9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DinB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DinB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994393.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13283"/>
    <dbReference type="EnsemblBacteria" id="EFK56080">
        <property type="protein sequence ID" value="EFK56080"/>
        <property type="gene ID" value="HMPREF0766_13283"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101283_0_0_10"/>
    <dbReference type="OrthoDB" id="2047691at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007837">
        <property type="entry name" value="DinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37302">
        <property type="entry name" value="PTHR37302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05163">
        <property type="entry name" value="DinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="167" mass="19500" checksum="073FBC9119F1DA0D" modified="2010-10-05" version="1">MSLKTLITNSVDYNVWVTEQLVTWLQSFDEELLYKECLSSFSSIAKTLKHISDTQLYWSAMIRGTAIPSFDYMATEVDIKTEMENLVNEAKLLATYVKENEEGMSETYLIESEWFSSNFPKYEYLQHLIIHTTYHRGQIVTIGHHVKGKKAPMMDYNFWNVMSQQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQV0</accession>
    <name>D7VQV0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994487.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13354"/>
    <dbReference type="EnsemblBacteria" id="EFK56151">
        <property type="protein sequence ID" value="EFK56151"/>
        <property type="gene ID" value="HMPREF0766_13354"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_28_1_10"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16925">
        <property type="entry name" value="TetR_C_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="196" mass="22588" checksum="18D375C78EB01416" modified="2010-10-05" version="1">MKKAETTRLTILQKAFELIYTKGYQTSSVDDILATTQVTKGAFYYHFKNKDEMGVAIINELMKPVLIKSFIEPLQHAENPLEAIYQLMYHLLMENDFLKVEYGCPAANFTQEMTPWNADFSKALNDISKQWVNIMTAVIEKGQQNGSVRKDVNAQQVTLFIMSGYWGIRNFGKLENSNKVYISYLNELENYLNSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR71</accession>
    <name>D7VR71_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13475"/>
    <dbReference type="EnsemblBacteria" id="EFK56272">
        <property type="protein sequence ID" value="EFK56272"/>
        <property type="gene ID" value="HMPREF0766_13475"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2791856_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="68" mass="8014" checksum="A30B0A6F82C83760" modified="2010-10-05" version="1">MLWFGCDKNEFPQYAVLGGNFNKSFLMSQPDFQHLLYFLLRIGGMLQVLCYCCALNRFRELRNRLCIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRC6</accession>
    <name>D7VRC6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4401 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994713.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13530"/>
    <dbReference type="EnsemblBacteria" id="EFK56327">
        <property type="protein sequence ID" value="EFK56327"/>
        <property type="gene ID" value="HMPREF0766_13530"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZCHA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1446807_0_0_10"/>
    <dbReference type="OrthoDB" id="1258345at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025513">
        <property type="entry name" value="DUF4401"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14351">
        <property type="entry name" value="DUF4401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4401" evidence="2">
        <location>
            <begin position="8"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="187" mass="20964" checksum="BDD01C3FD2A40B68" modified="2010-10-05" version="1">MIHIQIAVLTVLVSYTMLNEAKIITSTKVLSRLYKPVRAGLIFSFLVLLIFLGKKGMIALSPEYIWVSAVLIFLAIGYLMLKLSDILHVAGVIQRTVICILSILVLLPTVWSPAISGAILIILLSFYVNYKTGLIAGVIAFIYFISQYYYDLNFTLLTKSILLISLGILFLALYLFTRKSLTKHEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRD0</accession>
    <name>D7VRD0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4377 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994719.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13534"/>
    <dbReference type="EnsemblBacteria" id="EFK56331">
        <property type="protein sequence ID" value="EFK56331"/>
        <property type="gene ID" value="HMPREF0766_13534"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133616_2_0_10"/>
    <dbReference type="OrthoDB" id="1719779at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025485">
        <property type="entry name" value="DUF4377"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14302">
        <property type="entry name" value="DUF4377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107197" description="DUF4377 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4377" evidence="2">
        <location>
            <begin position="35"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="116" mass="13117" checksum="0A74A690A17EC8BC" modified="2010-10-05" version="1">MNFRVKLLSLFGVVLLSMACMKEERDVVRQVEMIVASKYTTCEPSYGVKVSDCLIVTEAKNNNTYYLAKSEIPGFSYELGYEYRILVKATKLANPPMDSGDTEFELIKVISKTKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRD9</accession>
    <name>D7VRD9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase A domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994728.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13543"/>
    <dbReference type="EnsemblBacteria" id="EFK56340">
        <property type="protein sequence ID" value="EFK56340"/>
        <property type="gene ID" value="HMPREF0766_13543"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_35_10"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="228"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="428" mass="49353" checksum="14D6FD41E7DD1AB1" modified="2010-10-05" version="1">MKKLLSKSIKPFIIYSLVVLLSSIPIYYFLVDGIWLSELDEHNEIVADRTENQLNKLNLSKQQLSESIRLWNSIQPGTNLHPFTDTRIPADSTYTIRKTNPYTEHEEIDRFRVLQRIIRINGQPYILTVETNVEETEETVIAIAIVTLLFFMILVVGFLILNKRLSINLWTPFRSTLSKLKTFNLNTQTTIEFDKSDTVEFEELNAALTKLLEHNITVFKSQKEFTENASHELQTPLAIMKNKLDLLLQQQQLTEEQYHIIEDINKALSRSARINKNLLLLAKIENLQFDDREDLDISLMIRQSLLVLQEHADQKELTITEKISPQIIKSGNTTLIEILLNNIIINAIRHTRPGGNITLTLNSQFLEVSNSGNSPLRQDLLFNRFSGTTSESSGSGLGLPIIKEICKRQKWDITYRFDNNLHCFRIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRF5</accession>
    <name>D7VRF5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, carbon-nitrogen family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994750.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13559"/>
    <dbReference type="EnsemblBacteria" id="EFK56356">
        <property type="protein sequence ID" value="EFK56356"/>
        <property type="gene ID" value="HMPREF0766_13559"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_3_2_10"/>
    <dbReference type="OrthoDB" id="1583074at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="318" mass="35936" checksum="8CDF4A0475B782FE" modified="2010-10-05" version="1">MDKLKIATAQFEHKSADKAYNLAVIERLAKEAASQGADVIAFHECSITGYTFARNLDKQQMLAIAERVPDGESTRQLIAIAARYDIIILAGLFEKDENDNLYKPYICIDKNGLIAKHRKLHPFINPHLTAGQNYTIFEIKGWKCGILICYDNNVIENVRTTKLLGADIIFMPHVTMCTPSSRPGAGFVDPQLWQNRENDPISLRLEFDGMKGRSWLMKWLPARAYDNAVYVVFSNPTGMDDDQLKNGCSMILDPFGDILAECHTFDDSFVTAILTPEKLIQAGGNRYLNARRPDLYRDIIGQQHEPTQKVVWLHSDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRG5</accession>
    <name>D7VRG5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994760.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13569"/>
    <dbReference type="EnsemblBacteria" id="EFK56366">
        <property type="protein sequence ID" value="EFK56366"/>
        <property type="gene ID" value="HMPREF0766_13569"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081790_1_0_10"/>
    <dbReference type="OrthoDB" id="1739932at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="55"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="237" mass="26861" checksum="2F9C2F4AB906B702" modified="2010-10-05" version="1">MEHKSTLREIEERFDQDVTRFSNLDTGQQTTLDALYNMELITDGIAASYAQLGDVLDVGCGAGNYPVKLLSKVRNPNITLVDLSQPMLDKAVERIQPLTSGRVDAIKADFQTLEFPAGSFDVIVATAVLHHLRTDADWESAFAKFYQWLRPGGSIWIFDLLIQQEAGIQQLIYKERYGAYLKGLKDEAYRDHVFAYIEKEDTPQTLVYQLDLLRLAGFKSVDVLHKNLCFASFVAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRK5</accession>
    <name>D7VRK5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994812.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13609"/>
    <dbReference type="EnsemblBacteria" id="EFK56406">
        <property type="protein sequence ID" value="EFK56406"/>
        <property type="gene ID" value="HMPREF0766_13609"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033A7G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132570_0_0_10"/>
    <dbReference type="OrthoDB" id="1915424at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="130" mass="15142" checksum="A99568391FB2675C" modified="2010-10-05" version="1">MKKGRLKLVSVILALVVLVQPFSRMAVFISFKINQDYISRVLCENRYKPELSCHGQCVLMKKIKKLEEKEHNQDMQIIKQLNELIYTQMTFDWSPAPLIIQTTDIRQYITDTPHVSSAYALSLFKPPRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRL1</accession>
    <name>D7VRL1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994824.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13615"/>
    <dbReference type="EnsemblBacteria" id="EFK56412">
        <property type="protein sequence ID" value="EFK56412"/>
        <property type="gene ID" value="HMPREF0766_13615"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033MT1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1136472_0_0_10"/>
    <dbReference type="OrthoDB" id="1869596at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="250" mass="28398" checksum="E018548C8B01C760" modified="2010-10-05" version="1">MERTIEQPNGENQPAGKSKKGLYITLTILCLLILGTGGYYFAVYKNGGQSIDEINAERQEAINSIFSVSEYDNIPDNYKAFIYNFLEYNNYLDGTEFLTKIADRAKYVYAFGNFTGDDDNEDDMAVLFEKNDYKSSSLVIFNHKGEGLLIKDYENELPVINSFKAGSRIYMDEARLVPAPCAGLIIKNENTKYALVYDKSTKKFNSYYQYTQQEIEDMDRMGPEDDISGDTPEEIESTPDTTHTTSESNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRN7</accession>
    <name>D7VRN7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994894.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13641"/>
    <dbReference type="EnsemblBacteria" id="EFK56438">
        <property type="protein sequence ID" value="EFK56438"/>
        <property type="gene ID" value="HMPREF0766_13641"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9YX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_949659_0_0_10"/>
    <dbReference type="OrthoDB" id="1951466at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="299" mass="35379" checksum="618A74C5A37BB541" modified="2010-10-05" version="1">MKHFEMENSENTYALLIGNDINNISPGKSWNDLLQEIKAKFHIQDIEDTDKPFPMLYEEIFLKAIKGGMKHEKELKTYIANRVTQINPNSIHEQIRQLPAAHIMTTNYEYTLEGQIPVNNNSVVRETTYSVYRRHQLHNKTYWHIHGECNSPNSINLGYEHYCGQLQGMRNYTISGTNYSNPRVNNTSFIRQLSKGKRLACQSWIDLFFTTDIHIFGLALDFVETDLWWLLTYRARSKFYKRSSFIRNTIYYYIPEHYTERSKAKLDLLKTHDVKIVIINENDKQSYYQCILDRLKNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRQ5</accession>
    <name>D7VRQ5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-dependent receptor plug domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_13659</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994940.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13659"/>
    <dbReference type="EnsemblBacteria" id="EFK56456">
        <property type="protein sequence ID" value="EFK56456"/>
        <property type="gene ID" value="HMPREF0766_13659"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_18_0_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="113"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="261"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="773" mass="86968" checksum="4F0BBB9CEBD4F700" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS59</accession>
    <name>D7VS59_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995324.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56610">
        <property type="protein sequence ID" value="EFK56610"/>
        <property type="gene ID" value="HMPREF0766_13813"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057295_0_1_10"/>
    <dbReference type="OrthoDB" id="1515911at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="140"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="282" mass="30307" checksum="047859C2C47525AB" modified="2010-10-05" version="1">MKNKNIAVPAALASMICVQGGASIAKKLFPVLGSAGTSTLRIGLSALLLFVINRPRLSALNKQQWLYCFGYGACIGSMNLIFYYAIQRIPLGLGVTVEFIGPLLLALFLSRKLLDLLWALFACAGILLIVPWQSNNIDIIGLGLAFLAGAFWAGYIVMGGKISQVVDNRVAVTVGMGIAAILILPFGMLSGSLAQLSFHYLLLGFGVAIFSSALPFTLDMIALKRLPPKTFSILTSLQPAFGALSGLLFLKEYLSFLQWMSILCVVIASMGTTLTNRYNDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS93</accession>
    <name>D7VS93_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13847"/>
    <dbReference type="EnsemblBacteria" id="EFK56644">
        <property type="protein sequence ID" value="EFK56644"/>
        <property type="gene ID" value="HMPREF0766_13847"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134973_7_0_10"/>
    <dbReference type="OrthoDB" id="2061355at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="71" mass="8464" checksum="4419081AFA7E8FD4" modified="2010-10-05" version="1">MMIKVYKTDVENSDMAYFITEQLLKRYPGFAINFDLMDCDNVLRVEGQSFQRDDIILFLNKIGYNCEEMCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSH3</accession>
    <name>D7VSH3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
            <ecNumber evidence="2">4.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995577.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13927"/>
    <dbReference type="EnsemblBacteria" id="EFK56724">
        <property type="protein sequence ID" value="EFK56724"/>
        <property type="gene ID" value="HMPREF0766_13927"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044590_3_0_10"/>
    <dbReference type="OrthoDB" id="1979322at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="3"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="275" mass="31811" checksum="3B873A27034EA1E4" modified="2010-10-05" version="1">MRIDSHQHFWHFDPVRDSWITDQMEVIRRDFLPQDLEFILQRNDIAGCIVVQADQSPSETEFLVRLAHQHPFIKGVVGWVDLRASNIDELLSTYQQESVIKGFRHIVEGESDPEFLIKDNFQNGLSRLSQYGFTYDLLIRPRHYASTLICVANHPDQRFILDHIAKPPIKSQEFFEWASFISALAEYPNVYCKVSGLATEADWSGWKPDHFSQYLNHVFLCFGKERIMFGSDWPVCLLAASYEDNLAIVGSRLDDFTSAEKEAFWGLNAVKAYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSR0</accession>
    <name>D7VSR0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-70 region 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fecI</name>
        <name evidence="4" type="ORF">HMPREF0766_14014</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995727.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14014"/>
    <dbReference type="EnsemblBacteria" id="EFK56811">
        <property type="protein sequence ID" value="EFK56811"/>
        <property type="gene ID" value="HMPREF0766_14014"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_12_0_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="126"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="191" mass="22597" checksum="FCB7ACFC416F08C2" modified="2010-10-05" version="1">MDYTHTLQMSDKQSSSLPEVVRNYGAQLLRFIKGKVKKVEDAEDILQEVWYQTSRLSNIDQLENVSAWLYSITRNKITDLYRKKKTDAIEDHTYMDDEGELKIKEILLADDSNNAELKLFKEVFWEELMKALDELPEKQRDVFVLNEIEDMTLQQIADLQGENIKTIISRKGYAVKHLRLRLNMLYEELKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSR1</accession>
    <name>D7VSR1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995730.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14015"/>
    <dbReference type="EnsemblBacteria" id="EFK56812">
        <property type="protein sequence ID" value="EFK56812"/>
        <property type="gene ID" value="HMPREF0766_14015"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7T3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052630_0_0_10"/>
    <dbReference type="OrthoDB" id="1381855at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024294">
        <property type="entry name" value="DUF3810"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12725">
        <property type="entry name" value="DUF3810"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="359" mass="41925" checksum="785EF175E6FB7F8E" modified="2010-10-05" version="1">MKNQLKRSGIVSLILIVLLIVFTLWQSNTHAVEMIFSRGWYPVFSYIPGTFFGYLPFSIGDVFYCTAIGFLIFLTGQTVCLVFKKMFYPALLRFSKLINLGLLLYLFFYISWGMNYYRQSVALNADIRVDSLKLADYLEVLDRFIDTTNTIRGRINPKVWKGKGRQIEQDMVATVENDTTFRSFLSVSNVRAKSPLNSRLVSYVGVSGYFNPFTHEAHVNTAMPEVAKPFTYVHELAHQQGIGFEDEANFIAFVRLQHHPNEFYRYSAYLQCVTYMLSELRGIDRNLFEQYRNRLSAKIESDLEEERAFWKTYMGWINDLTALFYNQYLQHNNQAEGIARYNRMTRLVLAYELQNKGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSS9</accession>
    <name>D7VSS9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995775.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14033"/>
    <dbReference type="EnsemblBacteria" id="EFK56830">
        <property type="protein sequence ID" value="EFK56830"/>
        <property type="gene ID" value="HMPREF0766_14033"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_4_10"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="230"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="447" mass="51728" checksum="FC7D36B65F91FCA1" modified="2010-10-05" version="1">MITHKLVIGIVIRTLIIAILIAVAIYCGIHSLWYVLTSIFIFLLILVFETRVFIKRYYSKFDSIVQAMLYDDYTLSFEEQKENIVLNQLIRLYEKNKKASFDLQSQAFIYQQLLNSLESGVLILKKSTDSWTVMNMNVYLRKYFGLPGITYWHQFKSFVPQFYEAIEQKNFAEYKSTIDIQINKEEKQTFVIQTSVSKVGDQQYYIILLDSIQRVIDSTENEAWLSIMKVIAHELMNSLTPIHSLAGNVSEILEQESLSAEDKEDVQISVDTILNRSYHLQKFVERYRRLTMLPSPQPEWIAVDPLIQNCLRGYSGILQQKGITLHYDVASDIRIFADAVQMEQVLINLFTNSMYAVENQSVKEIFLQVYTLNKRVYIEFADSGRIIDPEIVSRIFLPFYTTRKDGGGIGLTLSKSIVEAHGGYLFYQIKTDRNTFVLALPVTETEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSW3</accession>
    <name>D7VSW3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995856.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14067"/>
    <dbReference type="EnsemblBacteria" id="EFK56864">
        <property type="protein sequence ID" value="EFK56864"/>
        <property type="gene ID" value="HMPREF0766_14067"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3435">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130426_0_0_10"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="70"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="156" mass="17861" checksum="17664F5B9EF67001" modified="2010-10-05" version="1">MVNMKTEEKQFSSKDFHQTFARPAYIKPAKLIHQNVENAGVHNQFSAERKHPVFFVDLPSKNVSMTIGGLLPGQLTNRHRHTYETVLYVLEGAGYTEVEDERVEWKAGDAVYIPSWAWHRHQNLSDTEPAKYIACENAPQLQNLGVALREEEGRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSZ8</accession>
    <name>D7VSZ8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995911.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14102"/>
    <dbReference type="EnsemblBacteria" id="EFK56899">
        <property type="protein sequence ID" value="EFK56899"/>
        <property type="gene ID" value="HMPREF0766_14102"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50337IT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1561900_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="171" mass="20074" checksum="D91EAC62BA0622FC" modified="2010-10-05" version="1">MKNSLKSWTIMLSVIGILYIPLTALYRYNNLVPVTGIVTELIKTRTRIPYYKFRLAQYDNMFYHPGRGTLTLFKDELVQSDAPVEFYILKGDTGKLNKGDEILYMGYENKDIGIDVFYSITKPGLLIQFLTLIFYFTIMCLNACCAYRYREKWAERLIVVYFLFFILLMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTD5</accession>
    <name>D7VTD5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Resolvase, N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tnpX</name>
        <name evidence="8" type="ORF">HMPREF0766_14239</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14239"/>
    <dbReference type="EnsemblBacteria" id="EFK57036">
        <property type="protein sequence ID" value="EFK57036"/>
        <property type="gene ID" value="HMPREF0766_14239"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010686_17_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="6">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="7">
        <location>
            <begin position="158"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="4 5">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK57036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="410" mass="47726" checksum="81ACE7CBF74C0E95" modified="2010-10-05" version="1">MKTAYLYVRVSTDEQKKKGYSLPEQEDRLLKYCDYNHIKVLGVYREDHSAKDFNRPEWKKLLAIVKQKPREDKNILFIKWDRFSRNIEYAYEMIGLLRKYNSTPIAIDQPIDLSVPESTVMLAVYLSVPEAENSRRAMNTANGIRRAKQMGRFPGKAPLGYINMNGFDGRKIIVPKQPEANIIKWVFRQLAKNNNKIDHIRKIADAKGLKCSRSHFFRIIRNPTYCGLISIKISSKEQQMVKGIHDPLISEVLFNEVQRIITRKRIVTSKTNELNETFYLKSFLLCPICYKRLCGSFSKGKTKRYPYYHCNAKCKTRVNALTLNDAYCSELQSLQLSKNVTELFSSILEDCNINIQQAEDIQERNMLVRRLRDQGLLLSQARKLFVASVLGNDDYYAIKMEYQINSQSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTE1</accession>
    <name>D7VTE1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996276.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57042">
        <property type="protein sequence ID" value="EFK57042"/>
        <property type="gene ID" value="HMPREF0766_14245"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1065198_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="261" mass="30142" checksum="0BF9D944B00E9662" modified="2010-10-05" version="1">MASNATQSLNEFFLKVLTIQKSAQSINDNWLDSTKLSYSPHIFTDPFNVDIQSEKEQVDFFNKLLGRSDTEIKWAKKGSSGRQIVIDETNKTKLSIEFLSSIYCQLSVPVFEHICVFLKTLLGTNSSKSINIINEFDIEFQEQLVAIDNKKLLKTPTILILHNLRLFRNCITHNGGLVQALENDFIEFNKKIKEGKKFKNLQFYGALQKENFCYSINYEIGYIQLKGSSFIKLLDLYSQIAYMAYLCYCRKNNMPEEANIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTG9</accession>
    <name>D7VTG9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996357.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57070">
        <property type="protein sequence ID" value="EFK57070"/>
        <property type="gene ID" value="HMPREF0766_14273"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033PTY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1022720_0_0_10"/>
    <dbReference type="OrthoDB" id="2125878at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="272" mass="32069" checksum="8FA7723108011293" modified="2010-10-05" version="1">MNKYLKDCLIVFAVLLCIGLLIMAWIWWALENRHKDAERDGVEISLICDTVKMITEQPTLGFIKFEASDLETLKFQILRDGKFIEEKMIRTDFTKQNDDIIWKVSIPYKQFLKTDTIVLTTANKLIYYISDYHHYAYLQYGMFGYLGSHDCRFSEDCIINGRHSSGIIDRMDGWVNVEKAKHIAYLDPSTDEYEAFARSMPVKTRDAEIIFQDNRENKTLYSMYSYGIEVTPNESYYVFAEELENRRGHMDVIKINTRSGAYKRYKNYPFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTQ1</accession>
    <name>D7VTQ1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane insertion signal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001714.1">
        <property type="nucleotide sequence ID" value="NZ_GL379777.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14371"/>
    <dbReference type="EnsemblBacteria" id="EFK55810">
        <property type="protein sequence ID" value="EFK55810"/>
        <property type="gene ID" value="HMPREF0766_14371"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032ERD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082049_1_1_10"/>
    <dbReference type="OrthoDB" id="1739979at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025665">
        <property type="entry name" value="OMP_b-brl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13568">
        <property type="entry name" value="OMP_b-brl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107927" evidence="1">
        <location>
            <begin position="25"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl_2" evidence="2">
        <location>
            <begin position="26"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK55810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="231" mass="25485" checksum="738BD3496A0AA01C" modified="2010-10-05" version="1">MNIFKLYAAALSLMIISFTNSLQAQIKWGARVGVNFTALNAINEQEIELETEYVTRFSIGISADIPVISDFYVQPSLLYSGKGYKADAGSIGFSKGFNANVSYIELPLHILYKPKVGPGSLILGVGPYLAYGTGGKWKTDETVLIGDIMIDNKGDIKFKNDASTNDYGTYIYGKPWDYGTSAVIGYDLFNTYTFQLNAEWGMANLEPKWGSYKPKGERTNKGFGISVGYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTU8</accession>
    <name>D7VTU8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Dihydrofolate reductase</fullName>
            <ecNumber evidence="3 6">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">folA</name>
        <name evidence="9" type="ORF">HMPREF0766_14418</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="3 6"/>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002249.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14418"/>
    <dbReference type="EnsemblBacteria" id="EFK55727">
        <property type="protein sequence ID" value="EFK55727"/>
        <property type="gene ID" value="HMPREF0766_14418"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_5_1_10"/>
    <dbReference type="OrthoDB" id="1920912at2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="PTHR48069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000194">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="8">
        <location>
            <begin position="5"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK55727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="164" mass="19019" checksum="83B959C5BD2589A4" modified="2010-10-05" version="1">MSHLKITLIVAAAENNVIGKDNQMPWHLPNDFKYFKKNTLEHSVIMGRKTFEAIGKALPDRRNIVISRNQDFHHPDVDTANSLQEAILYCRDEREVFVIGGANIYEQTLPFAHKVLLTRVHTTIEGDAVFPVLNPEEWALESEEKHFADDRHAFDYTFQIFNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTU9</accession>
    <name>D7VTU9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding domain of DNA photolyase</fullName>
            <ecNumber evidence="7">4.1.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">phr</name>
        <name evidence="7" type="ORF">HMPREF0766_14419</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DNA photolyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.3" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002251.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14419"/>
    <dbReference type="EnsemblBacteria" id="EFK55728">
        <property type="protein sequence ID" value="EFK55728"/>
        <property type="gene ID" value="HMPREF0766_14419"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0415">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010348_2_2_10"/>
    <dbReference type="OrthoDB" id="184000at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901363">
        <property type="term" value="F:heterocyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097159">
        <property type="term" value="F:organic cyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="PTHR11455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="SSF52425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00691">
        <property type="entry name" value="DNA_PHOTOLYASES_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="6">
        <location>
            <begin position="5"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK55728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="437" mass="51165" checksum="91435E0B1C57D439" modified="2010-10-05" version="1">MSAVPTVIFWFRRDLRLQDNHALFRALNSEAAVQPVFIFDSTILTRLDDPADARVTFIYQQLQLLQEQLKPYGSSIRTYYGEPATVWEEIYEEYTPTAVYVNSDYEPAAITRDLLVRGILQQYKVDFNTFKDQVIFEKAEIVKNDGLPYTVYTPYKNKWLTTLEEQLPLPSYTSENLLKNLRQASYALPSLQDLGFSLSTIPFPEKTFFTAIADYADTRDIPGLENGTSHLGIHLRFGTISIRKLVERAYPSQNKTYLHELIWREFFMMCLWHFPHTVNHAYYSKYDHIRWENNVAHFEAWCNGQTGYPLVDAGMRELNTTGFMHNRVRMLTASFLCKHLLIDWRWGEAYFAQKLLDYDQSANIGNWQWAAGCGMDAAPYFRIFNPTLQTKKFDPQFVYIKKWVPEFQDFSYPPPIVEHAWARDRALARYKAGFEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTW1</accession>
    <name>D7VTW1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002276.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14431"/>
    <dbReference type="EnsemblBacteria" id="EFK55740">
        <property type="protein sequence ID" value="EFK55740"/>
        <property type="gene ID" value="HMPREF0766_14431"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024854_0_0_10"/>
    <dbReference type="OrthoDB" id="301769at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="684" mass="79080" checksum="B6FA6B459957DE8F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGB2</accession>
    <name>D7VGB2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen synthase</fullName>
            <ecNumber evidence="7">2.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Starch [bacterial glycogen] synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">glgA</name>
        <name evidence="10" type="ORF">HMPREF0766_10031</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Synthesizes alpha-1,4-glucan chains using ADP-glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18189"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.21" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001895.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10031"/>
    <dbReference type="EnsemblBacteria" id="EFK60087">
        <property type="protein sequence ID" value="EFK60087"/>
        <property type="gene ID" value="HMPREF0766_10031"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_18_2_10"/>
    <dbReference type="OrthoDB" id="83240at2"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00484">
        <property type="entry name" value="Glycogen_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011835">
        <property type="entry name" value="GS/SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02095">
        <property type="entry name" value="glgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 7 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_5" evidence="9">
        <location>
            <begin position="3"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="8">
        <location>
            <begin position="281"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ADP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK60087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="473" mass="53102" checksum="1CEB16833BB80A9A" modified="2010-10-05" version="1">MMNVIHLSVECYPVAKVGGLADVVGALPKYQNRLGIHASVVMPWYDKPFILQHSFAVIATGRFTMGSATIPYEVWKEQDQVLGYELYMIRIPGYLDRADVYGYADEGEQFIAFQHAFLDWLVQSDQTPDVVHCHDHHVGLIPFLMQWGNDFERLRKVKTVLTVHNGQYQGWMNWSKGILLPAFDTWKWGLLDWDGLINPLAAAVKCCTAFTTVSEGYLRELYTDANGLQSLFADESGKGYGIVNGIDTEIWDPQTDPAVKVHYQAKNVTSGKRANKEAFCKAYGLDPKVPLLVFIGRFATEKGADLLNEIIVNLFEVKNEKLSIFILGSGDQEIRASLEGLTGHYEGRFAAFFGYDESLAHWVYASADLLLMPSRVEPCGLNQLYSLRYGTVPVVRTIGGLKDTVIDIAAENGYGISFDEATVESAIAGIQRAILFAEDKARFDKNRKKIMSLDFSWDSSAKKYIHLYNQINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGS5</accession>
    <name>D7VGS5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
            <ecNumber evidence="5">3.6.3.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lolD</name>
        <name evidence="5" type="ORF">HMPREF0766_10194</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.28" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996832.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10194"/>
    <dbReference type="EnsemblBacteria" id="EFK59277">
        <property type="protein sequence ID" value="EFK59277"/>
        <property type="gene ID" value="HMPREF0766_10194"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_10"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="217" mass="23714" checksum="1FC6A8BECD47CB2B" modified="2010-10-05" version="1">MMLQAKGIYKAYGDLPILKGVDLEVDKGEIVTIVGASGAGKSTLLHIIGTLDRPESGEVWIDGIKVSGLNEKKLSAFRNKHIGFVFQFHHLLPEFTALENVCIPAFINGVPKKDAEANAMQLLDMLGVAHRVTHKPSAMSGGEQQRVSVARALINKPSIVLADEPSGNLDSENATALHQLFFDLRDKIQQTFVIVTHNDELANISDRTIHMRDGNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGW9</accession>
    <name>D7VGW9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.117</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dapD</name>
        <name evidence="6" type="ORF">HMPREF0766_10238</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.117" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996957.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10238"/>
    <dbReference type="EnsemblBacteria" id="EFK59321">
        <property type="protein sequence ID" value="EFK59321"/>
        <property type="gene ID" value="HMPREF0766_10238"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050859_0_1_10"/>
    <dbReference type="OrthoDB" id="752123at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008666">
        <property type="term" value="F:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.166.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023180">
        <property type="entry name" value="THP_succinylTrfase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037133">
        <property type="entry name" value="THP_succinylTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14805">
        <property type="entry name" value="THDPS_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THDPS_N_2" evidence="5">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK59321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="273" mass="29896" checksum="8A71E581F055C923" modified="2010-10-05" version="1">MELENLQKLIEDAWEDRQLLEYKEYAEAIRTIILKLDNGEIRVAEPIGTRWHVNEWIKKAVILYFPIREMVETEAGPFVYYDKMKLKTNYKHLGVRVVPGASARLGAYLAKGVILMPSYVNIGAYVGEGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPVQASPVIIEDNVFVGSRVIVVEGVRVESEAVLGANVVLTASTKIIDVTGSEPVEYKGHVPARSVVIPGSYTKKFPSGEYQVPCALIIGKRKESTDKKTSLNDALRDHNVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH19</accession>
    <name>D7VH19_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antioxidant, AhpC/TSA family</fullName>
            <ecNumber evidence="2">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.15" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997095.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10288"/>
    <dbReference type="EnsemblBacteria" id="EFK59371">
        <property type="protein sequence ID" value="EFK59371"/>
        <property type="gene ID" value="HMPREF0766_10288"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1433650_0_0_10"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="19"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="189" mass="21798" checksum="EE206357298FE0F5" modified="2010-10-05" version="1">MRYIIIVIFLLFGKNLTGAQLSLDYSSINAVKTLQNKDYDFVNLNNKPHVFIFYSSDCPLSQKYTLTISNLYNKYTGKINFVGVFPGKEHGPEEYQNFKDKYNINYMLIKDEKFNLTSHLKATITPEVFLIDKSGKIIYHGAIDDWAVKLGKTKQQPTINYLENAIESLLNNKNVQSDYIKPIGCYIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH88</accession>
    <name>D7VH88_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Antioxidant, AhpC/TSA family</fullName>
            <ecNumber evidence="8">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">prdX</name>
        <name evidence="8" type="ORF">HMPREF0766_10357</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.15" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997239.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10357"/>
    <dbReference type="EnsemblBacteria" id="EFK59440">
        <property type="protein sequence ID" value="EFK59440"/>
        <property type="gene ID" value="HMPREF0766_10357"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_4_2_10"/>
    <dbReference type="OrthoDB" id="892697at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="3"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="211" mass="23729" checksum="7586184131F3D9D5" modified="2010-10-05" version="1">MSLRLGDEAPNFKAQTTIGDIDFHDYIKDSWVVFFSHPSDYTPVCTTELGRTAKLKSEFDKRGVKALALSVDNLEDHHNWVKDINETQDTTVNFPIVADVDRHISELYDMIHPNASATATVRSVFIIGPDKKIKLTLTYPASTGRNFDEILRVIDSLQLTADYSVATPADWKHGEDVIVVPAIKTEDIPAKFPKGFKEIKPYLRTTPQPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHD3</accession>
    <name>D7VHD3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pruA</name>
        <name evidence="11" type="ORF">HMPREF0766_10402</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997346.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10402"/>
    <dbReference type="EnsemblBacteria" id="EFK59485">
        <property type="protein sequence ID" value="EFK59485"/>
        <property type="gene ID" value="HMPREF0766_10402"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_4_1_10"/>
    <dbReference type="OrthoDB" id="744602at2"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:1-pyrroline-5-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="10">
        <location>
            <begin position="58"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK59485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="545" mass="60502" checksum="2531E3A345A28DCB" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHI2</accession>
    <name>D7VHI2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rplN</name>
        <name evidence="6" type="ORF">HMPREF0766_10451</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997484.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10451"/>
    <dbReference type="EnsemblBacteria" id="EFK59534">
        <property type="protein sequence ID" value="EFK59534"/>
        <property type="gene ID" value="HMPREF0766_10451"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_2_1_10"/>
    <dbReference type="OrthoDB" id="1799923at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK59534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="122" mass="13464" checksum="8E6AB6EA91BB5770" modified="2010-10-05" version="1">MVQQESRLNVADNSGAKEVLVIRVLGGTRKRYASIGDKIVVTVKSALPSGNVKKGSVSKAVVVRTKKEIRRKDGSYIRFDDNAAVLLNNNDEPRGTRIFGPVARELREKQFMKIVSLAPEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHP2</accession>
    <name>D7VHP2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997592.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10511"/>
    <dbReference type="EnsemblBacteria" id="EFK59594">
        <property type="protein sequence ID" value="EFK59594"/>
        <property type="gene ID" value="HMPREF0766_10511"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZPB9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151808_0_0_10"/>
    <dbReference type="OrthoDB" id="1755883at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="129" mass="15008" checksum="87F5C31AF77587EB" modified="2010-10-05" version="1">MSFSKIEKYITETGYKIVHKNEDEGVFVIENELDGIRNLIVGVAMPIIIFEQYLFTIRNESLEMFKELLVKNRDIIHGGFALTEDGEKVIYRYTLQIHNLDLNEFQAALSSLSLLMSEYKEQLISFSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHW1</accession>
    <name>D7VHW1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_10580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997786.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10580"/>
    <dbReference type="EnsemblBacteria" id="EFK59663">
        <property type="protein sequence ID" value="EFK59663"/>
        <property type="gene ID" value="HMPREF0766_10580"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_2_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106917" evidence="5">
        <location>
            <begin position="25"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="118"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="412"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="994" mass="107954" checksum="DDF6817921B81AEB" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHY7</accession>
    <name>D7VHY7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arylsulfatase</fullName>
            <ecNumber evidence="7">3.1.6.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_10606</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.-" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997842.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10606"/>
    <dbReference type="EnsemblBacteria" id="EFK59689">
        <property type="protein sequence ID" value="EFK59689"/>
        <property type="gene ID" value="HMPREF0766_10606"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_9_3_10"/>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="DUF4976"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="DUF4976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107245" evidence="4">
        <location>
            <begin position="21"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="6">
        <location>
            <begin position="397"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="508" mass="59143" checksum="7BBC50AE7FEDAB7A" modified="2010-10-05" version="1">MMNRYLLICFFILISCISKAQNKPNILIIISDDHSFQTIGAYGSSVARTPNIDRIAKEGAVFDRAYVTNSLCGPSRATLLTGKYSHKNGFKDNENSHFDHSQSTFVKDLQGAGYRTAWIGKQHLGAKPQGFDYYSILDGQGHYFNPVFINQGDKREQIEGYVSDIVTEKAEKWLDTLNKDKPFCLILGHKATHRSWLPDPKDFGTYDQAEIPLPDNFYDQYDKRKAAAVQEMSIAKDMLLPYDLKMYPTKEDMRKDYDFSRFTESQFEKYYAYYKPIQDDFYARKLSGRQLEEWKYRRYMIDYLNTAASLDRNIGEVLDYLDTHGLKNNTIVIYLSDQGFYMGEHGWFDKRFMYEESFRTPMVARYPGVIKPGTHTEARVMNIDIAPTLLEIAGVRIPKEIQGKSFYSVLKDAKKPFRKSSYYHYYENGTHAVSPHFGVSDGKYKLIRFYKRVESWELYDLEKDPHEMHNIYADKSSDSIIGRMKKKLLAEIRLVDDKEAEAIFEQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI19</accession>
    <name>D7VI19_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glyceraldehyde 3-phosphate dehydrogenase domain protein</fullName>
            <ecNumber evidence="4">1.2.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gap</name>
        <name evidence="4" type="ORF">HMPREF0766_10638</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997907.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10638"/>
    <dbReference type="EnsemblBacteria" id="EFK59721">
        <property type="protein sequence ID" value="EFK59721"/>
        <property type="gene ID" value="HMPREF0766_10638"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030140_1_1_10"/>
    <dbReference type="OrthoDB" id="944149at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="3">
        <location>
            <begin position="130"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="482" mass="53175" checksum="127A76EA245D6C0B" modified="2010-10-05" version="1">MSSKVLFEQEISSYTKKTEAAKTFINIISRLWYEQAIELVLFRNQLIDRQNSHILNLHHEAAVFAENNISIFDSLAVADTLQDLRLPPSRIDVGTLAMEMKNEGIAPTDLHDFLIRKLCKAHQTKEITPRDVILYGFGRIGRLLARELIAKAGSGRQLRLRAIVTRDQVNETTLRKRAALLQHDSIHGDFEGTVEIDITNKALVINGLTVYILSAQAPEEIDYTAYQISNALVIDNTGAFRNAEELSRHLKSKGTANVLLTAPGKAVPNIVYGINQDEIDVSKTAIYSAASCTTNAIAPVLHIIENKLGIIKGHIETIHAYTNDQNLVDNMHKKFRRGRAAALNMVITETGAGSAVAKAIPSLAGKLTSNAIRVPVPNGSLAILHLETRQTTDVETLNKLIKTAALKGDLVEQIKYAVNEELVSSDIVGTSSCSIVDAPATIVSADGHSIVLYVWYDNEYGYAQQVMRLSRHIAGVRRFVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI36</accession>
    <name>D7VI36_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YqgF HJR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997942.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10655"/>
    <dbReference type="EnsemblBacteria" id="EFK59738">
        <property type="protein sequence ID" value="EFK59738"/>
        <property type="gene ID" value="HMPREF0766_10655"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098240_2_1_10"/>
    <dbReference type="OrthoDB" id="2075502at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="YqgFc" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="138" mass="15324" checksum="5F593888AAB87A43" modified="2010-10-05" version="1">MRLMAFDYGTKRIGIAVTDPLQIVANALTTVHPDEIVDFLKNYLQTEQVETFVVGKPRQMDGSDSESASHVIGFIRLLKKQFPAIPVAEVDERFTSKMASAVIAQSGMKKGKRQQKGLVDTISATIILQSYMDSRSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI58</accession>
    <name>D7VI58_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_10677</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997985.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10677"/>
    <dbReference type="EnsemblBacteria" id="EFK59760">
        <property type="protein sequence ID" value="EFK59760"/>
        <property type="gene ID" value="HMPREF0766_10677"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_1_0_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106979" evidence="2">
        <location>
            <begin position="24"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="4">
        <location>
            <begin position="122"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="3">
        <location>
            <begin position="408"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1034" mass="114261" checksum="626845322BA2C915" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI59</accession>
    <name>D7VI59_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">F5/8 type C domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997986.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10678"/>
    <dbReference type="EnsemblBacteria" id="EFK59761">
        <property type="protein sequence ID" value="EFK59761"/>
        <property type="gene ID" value="HMPREF0766_10678"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1453552_0_0_10"/>
    <dbReference type="OrthoDB" id="1674879at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="186" mass="21148" checksum="E1199963E913DE8E" modified="2010-10-05" version="1">MKKLTKFQQAFVLCGLFACLTGCDKTEVRQYDLLESEKEPEMDITAYGNLSVNRENSGGKTANEGSLKVVDQDYNTKFLINPYYDDLYMQLSFPGGISVGAYILASANDAQDRDPKDWELMGSNDGSAWISVDSKQGYLFTSRNQKVRFDINNKEKYRYYRLNVKAIRGGTGLFQLAEWRVINVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIB2</accession>
    <name>D7VIB2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998094.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10731"/>
    <dbReference type="EnsemblBacteria" id="EFK59814">
        <property type="protein sequence ID" value="EFK59814"/>
        <property type="gene ID" value="HMPREF0766_10731"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50332J0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1814609_0_0_10"/>
    <dbReference type="OrthoDB" id="2070656at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107523" evidence="1">
        <location>
            <begin position="23"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="142" mass="15693" checksum="9BA5681515E66CFC" modified="2010-10-05" version="1">MAKIIILSFFFVLLLSSCNSGGSGGSDKSKTKNVAIAHNAKSDGCTVEAVVRKLSELEEIKEQKAVLDSLFADKPNISFMVDSADVNGKQVYTVTAGYNGELRYEPYYHFYVNKATCGDIEVMDVVSGDYLTLDEWRKSRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIE7</accession>
    <name>D7VIE7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0766_10766</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0702 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998160.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10766"/>
    <dbReference type="EnsemblBacteria" id="EFK59849">
        <property type="protein sequence ID" value="EFK59849"/>
        <property type="gene ID" value="HMPREF0766_10766"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2323">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089304_0_0_10"/>
    <dbReference type="OrthoDB" id="1884218at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007353">
        <property type="entry name" value="DUF421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023090">
        <property type="entry name" value="UPF0702_alpha/beta_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04239">
        <property type="entry name" value="DUF421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="225" mass="25630" checksum="3CD9FBE9EC1A6B28" modified="2010-10-05" version="1">MDGFRKIFLEGVEWGFLGEIVVRSVIMFALILIILRLSGKKGVRQLTLFEVAIILSLGSAAGDPMFQEELPVLYAFVVLFSVILIYKFVTWASSKSAFLNKMLEGRAMVVVRAGEFDLKHEHDGDFSKMEFFSELRNQSVEHLGQVKMAVLEVDGTMSILFYADKEVKYGLPLFPDDYRQVKEEFQSGPFACMYCGRVEEVMPEGGFCRRCNRTKWAKAMDSTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIN1</accession>
    <name>D7VIN1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphatidylglycerol lysyltransferase</fullName>
            <ecNumber evidence="5">2.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Lysylphosphatidylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HMPREF0766_10850</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:10668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:75792"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="EC" id="2.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LPG synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.3" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998328.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10850"/>
    <dbReference type="EnsemblBacteria" id="EFK59933">
        <property type="protein sequence ID" value="EFK59933"/>
        <property type="gene ID" value="HMPREF0766_10850"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2898">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_332582_0_0_10"/>
    <dbReference type="OrthoDB" id="542304at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050071">
        <property type="term" value="F:lysyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="417"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="LPG_synthase_C" evidence="13">
        <location>
            <begin position="553"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFK59933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="865" mass="98764" checksum="4AC9E9F0BDBFB258" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIS3</accession>
    <name>D7VIS3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10892</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998417.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10892"/>
    <dbReference type="EnsemblBacteria" id="EFK59975">
        <property type="protein sequence ID" value="EFK59975"/>
        <property type="gene ID" value="HMPREF0766_10892"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_7_2_10"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="63" mass="6982" checksum="11F89C69AF1B1015" modified="2010-10-05" version="1">MQEGVVKFFNEAKGFGFIIPNSGEGEIFVHVTGLIDKIRENDNVSYEVEQGRKGLNAVNVKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIZ3</accession>
    <name>D7VIZ3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998557.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10962"/>
    <dbReference type="EnsemblBacteria" id="EFK60045">
        <property type="protein sequence ID" value="EFK60045"/>
        <property type="gene ID" value="HMPREF0766_10962"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094580_0_0_10"/>
    <dbReference type="OrthoDB" id="1391177at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK60045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="254" mass="29124" checksum="1486C7B8A696FF83" modified="2010-10-05" version="1">MRTRLYILFFILFLGKINPLFAQKQIEGIVFDMDTKQRIAKVNIRNVSGGGEVFNNSKGEFQIKAKKGDILIASSKGFHGDTVKVEDSPVILFYLKRATIYLQEVTVKGRKTPEEILQQERENYNKAYRLADPGSVFSVGPTGAGVSINAIYSLFSKEVKNAKRLTRLIENDYKENMIDYKFTEALVVKVTGLKDERLKDFMTQYRPSYFFVISATEYQMTSYIQSSYEQYISNPALKRLPLLPDITLDITPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ03</accession>
    <name>D7VJ03_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998577.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10972"/>
    <dbReference type="EnsemblBacteria" id="EFK60055">
        <property type="protein sequence ID" value="EFK60055"/>
        <property type="gene ID" value="HMPREF0766_10972"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030C5C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084444_0_0_10"/>
    <dbReference type="OrthoDB" id="2016798at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="235" mass="26640" checksum="0F7A4F418EBF90BF" modified="2010-10-05" version="1">MLENLPIYIPLTFGLITVATLFLFSWVIKTSTSPTTRKNSPIIIISLIIWLIIQAVLTLKNVYNSDTNSFPPKILLFGILPTLLAIAVLFSMKKGQRFIDSLSLTNITYLNIVRIPVEVVLFWLFLNKVIPELMTFEGRNLDIIAGITAPIVAYFGLVKEKINRKTILIWNFICLGLLINIVVNAFFSAPSPIQKFAFEQPNIAILNFPFSWLPTFIVPIVLFGHLVSIRRLLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ30</accession>
    <name>D7VJ30_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002134.1">
        <property type="nucleotide sequence ID" value="NZ_GL379779.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10999"/>
    <dbReference type="EnsemblBacteria" id="EFK59165">
        <property type="protein sequence ID" value="EFK59165"/>
        <property type="gene ID" value="HMPREF0766_10999"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_2_4_10"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="283" mass="32097" checksum="14F868144E34FE22" modified="2010-10-05" version="1">MNKPLLVPVDFSENAQTAVSYAAQIADISKRDVHVIHIMTEHTNRFANATWNKDLMEPLIKEALSQLDTFLLPVKARYPDIVFTTAIRDGVLTDQLLDEAKGEKYAAIVMGTKGSSGLDSVFIGSNAYDVIKTTETPVLIVPKHIEALQLNNIGLLCNFKEGELEVLKQAVSLFGNKFHLQLIHINRADEDVETVDQKLKMWIDRIIKETQIDDISYIVKSPAYFYRNKETIAHAIQQILIDESVDMLLVTKGRKNFFRYIFSENIAKELAFQSKIPNLFARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ70</accession>
    <name>D7VJ70_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000402.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11039"/>
    <dbReference type="EnsemblBacteria" id="EFK58923">
        <property type="protein sequence ID" value="EFK58923"/>
        <property type="gene ID" value="HMPREF0766_11039"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_325937_0_0_10"/>
    <dbReference type="OrthoDB" id="300987at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="878" mass="99616" checksum="109E72206D539A07" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ81</accession>
    <name>D7VJ81_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11050"/>
    <dbReference type="EnsemblBacteria" id="EFK58934">
        <property type="protein sequence ID" value="EFK58934"/>
        <property type="gene ID" value="HMPREF0766_11050"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011828_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039565">
        <property type="entry name" value="BamD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13525">
        <property type="entry name" value="YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YfiO" evidence="1">
        <location>
            <begin position="638"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1040" mass="119710" checksum="4C57F213571EE88D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJF4</accession>
    <name>D7VJF4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11123"/>
    <dbReference type="EnsemblBacteria" id="EFK59007">
        <property type="protein sequence ID" value="EFK59007"/>
        <property type="gene ID" value="HMPREF0766_11123"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081813_0_0_10"/>
    <dbReference type="OrthoDB" id="1332232at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="311" mass="35801" checksum="11E85F1AAB134A0C" modified="2010-10-05" version="1">MPKFMCPYNTIVIGSLRNRQSLMKFIRQLFYISIYTNLLIALAAMAQCALTYYVFSQPMNYAIILVEGAATLMLYNFSLLWSRPENPQESRFARTRWVFGNEWVLWLNTIIAAGILLYCLFQIHFNSFLFLGVIGLLSVLYGFPVFRYQGRRVGLRQLPGAKIFHIAFVWVCSSVILPYIELFSEGIMINTRLLGALAVLKFLLLIICTLPFDIRDIAQDSYYHLKTLPNMLGEKKAKRLCYTLLLIHITLIAVTGYNPGIVLGLLLTDILIAAFLKFFVFRKEGHYHYAYLLDLSLILQFVLVFLTVNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJL2</accession>
    <name>D7VJL2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fasciclin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000720.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11181"/>
    <dbReference type="EnsemblBacteria" id="EFK59065">
        <property type="protein sequence ID" value="EFK59065"/>
        <property type="gene ID" value="HMPREF0766_11181"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_526458_0_0_10"/>
    <dbReference type="OrthoDB" id="759139at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033401">
        <property type="entry name" value="DUF5108"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17133">
        <property type="entry name" value="DUF5108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="41"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="182"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="538" mass="61268" checksum="DC3DFDFCAC523B34" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJV7</accession>
    <name>D7VJV7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11276"/>
    <dbReference type="EnsemblBacteria" id="EFK58559">
        <property type="protein sequence ID" value="EFK58559"/>
        <property type="gene ID" value="HMPREF0766_11276"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044440_1_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107223" evidence="1">
        <location>
            <begin position="20"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="325" mass="35178" checksum="35C264365D566FD9" modified="2010-10-05" version="1">MKILNFLVSLLLCVNITNAQTNTFPASGPVGIGTTSPKAILDVAAPYIHNDRLGTVFGRLEEGDETGSGTFLGVQGTGTNVIGGKSFSLIHSFYGQINNAINFHRGVSVTGGFISFNTNNNTERMRLDENGHLLLGTTSVDNNEGWDRAFQVNGEGHAKMLVTTGVVKSGLWSHESGYYGAVAGGIVGTHSNHPFSIITNGASKVTVLANGYTGIGTATPTERLAVNGNIRAKEIKVEAANWPDYVFKKDYELKPLSELQSYIEEHGHLPDMPKAAEAEKEGVSLGEMNKLLLKKVEEMTLYILQMQKNNEVQQAQINQLLIQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK03</accession>
    <name>D7VK03_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_11322</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11322"/>
    <dbReference type="EnsemblBacteria" id="EFK58605">
        <property type="protein sequence ID" value="EFK58605"/>
        <property type="gene ID" value="HMPREF0766_11322"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_2_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="234"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="608"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1172" mass="130276" checksum="FB8569E92B33C847" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK83</accession>
    <name>D7VK83_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999018.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11402"/>
    <dbReference type="EnsemblBacteria" id="EFK58685">
        <property type="protein sequence ID" value="EFK58685"/>
        <property type="gene ID" value="HMPREF0766_11402"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1155803_0_0_10"/>
    <dbReference type="OrthoDB" id="2160418at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="240" mass="28911" checksum="218B41291FAF8A4F" modified="2010-10-05" version="1">MEHSPELLISQYEAEKKKLQKLIRNCVKEMEYLEAHHHSRALSRLNQRLRTLYKLTDNLYEKKEHEQRNIRFYEKLLKDKKLLYAKEYFEESLHKSKEELEKLNLQPVSKPIQQDPDLFQHILEKLLANSIKDLKLILNKQENIHLNITYSRKTLKVTIPHIKKLLEKHVWNEFQIHHLLKSGFESDHNGTRLTLILKGEKQQILSRLHYTIGKIVFEIFDFRDFTNESYLHYNEVGSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKA7</accession>
    <name>D7VKA7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0766_11426</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999078.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11426"/>
    <dbReference type="EnsemblBacteria" id="EFK58709">
        <property type="protein sequence ID" value="EFK58709"/>
        <property type="gene ID" value="HMPREF0766_11426"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_10"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="22"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="369"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="401"/>
            <end position="408"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK58709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="607" mass="67579" checksum="FD45B4CF00751940" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKE4</accession>
    <name>D7VKE4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase, family 88</fullName>
            <ecNumber evidence="4">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999180.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11463"/>
    <dbReference type="EnsemblBacteria" id="EFK58746">
        <property type="protein sequence ID" value="EFK58746"/>
        <property type="gene ID" value="HMPREF0766_11463"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027158_0_0_10"/>
    <dbReference type="OrthoDB" id="859760at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107609" evidence="3">
        <location>
            <begin position="29"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610905-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610905-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="414" mass="47238" checksum="BFADF3AE86B22846" modified="2010-10-05" version="1">MTLLFKATALSMLALTLACSSTSGNFVAKDFERAEEQYTLLLNNSKDITIFPRTLDSAGNVKGTDVWDWTGGFFAGSLWNIYEYSKDPKWEAAAIKWTEALEEGKFLTQHHDIGFVMYCSYGNAIKNLKDTAKINAYNKILIQSGESALTRYNPKVGLIKSWNSKMSWDKKTLWNYPVIIDNMMNLEMLFYVSKLTGDDKYKKVAISHADQTMKYHFRPDYSTYHVVDYDTTSGKVLHQQTNQGFADNSTWSRGQAWAVYGYTVMYRETKDPKYLATAEHAADFFLNHANLPEDKIPYWDFNVNQEGYKPDWAYDSKRFDVIHRDASAAAVIASALLELSGYAEEKGRTYLNAAEQILKSLSSDEYLAQKGTNGGFLLLHSVGSMPHNSEIDVPLTYADYYFLEALNRYRELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKK4</accession>
    <name>D7VKK4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phytoene desaturase</fullName>
            <ecNumber evidence="5">1.14.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">crtI</name>
        <name evidence="5" type="ORF">HMPREF0766_11523</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 3">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999345.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11523"/>
    <dbReference type="EnsemblBacteria" id="EFK58806">
        <property type="protein sequence ID" value="EFK58806"/>
        <property type="gene ID" value="HMPREF0766_11523"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019722_2_1_10"/>
    <dbReference type="OrthoDB" id="418913at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="4">
        <location>
            <begin position="10"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="493" mass="56260" checksum="C74F2664A42EC77C" modified="2010-10-05" version="1">MNVSVIGSGISGLAAACYLAKQGHTVSVFEKNSTAGGRARQFREEGFVFDMGPSWYWMPDIIASFFQDFGHEVSDYYELQRLDPSYTIIFDDMELPVPADMTELENLFESIEPGSKQKLRQFMQNAAVKYEMGLKKYATFPSLSVMEYVQPDIFKALMRLDLLSNMDTHVNKYFKNPYLQKLMKFPVLFLGAMPDKIPAMYSLMNYADASLGTWYPKGGMYNIIEAQYKLAKELGVSFYFDHDINELHVEERHVKGLKVNNKIIHSDFVIASGDYHYMEQLLPAHLRNYNEAYWSKRQMAPTCLIFYLGINKKLPLTHHTLFFDSDFNAHARSLYDKEEWPKEPMFYVCAPSVTDPSVAPEGHENLFVLIPLASGLEEGIEEIASFYFENVIRRMETRLQTDIMSHICYQKKYSIKDFKDDYHAFKGNAYGLANTLGQTAFGKPSLKNRKVDNMLYCGQLSVPGPGVPPALLSGKIVADQVARYLSKTSSPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKP6</accession>
    <name>D7VKP6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">uppS</name>
        <name evidence="3" type="ORF">HMPREF0766_11565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999429.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11565"/>
    <dbReference type="EnsemblBacteria" id="EFK58848">
        <property type="protein sequence ID" value="EFK58848"/>
        <property type="gene ID" value="HMPREF0766_11565"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038505_1_1_10"/>
    <dbReference type="OrthoDB" id="1630604at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="22"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="66"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="195"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="245" mass="28169" checksum="98377B2DB05FBBE7" modified="2010-10-05" version="1">MNIKDKIDRNNLPQHVAIIMDGNGRWAKGLGKLRIFGHQNGVSAVREAMEGAVELGIPYLTLYAFSTENWNRPKLEVLALMELLVTTLSKEIKTFQDNGIRLNTIGDIDKLPKNCRAKLIESMELTAQNTTCVLTLALSYSSQKEIVDATKEICKQVMQGNLDIDAIDEKVFANHLYTRNMPDPDLLIRTSGEQRISNYLLWQIAYSELSFLPKMWPEFTREDLYECVYNYQQRERRFGKTSEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKR2</accession>
    <name>D7VKR2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bacillithiol system thiol disulfide oxidoreductase, YpdA family</fullName>
            <ecNumber evidence="1">1.8.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ypdA</name>
        <name evidence="1" type="ORF">HMPREF0766_11581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.-.-" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999458.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11581"/>
    <dbReference type="EnsemblBacteria" id="EFK58864">
        <property type="protein sequence ID" value="EFK58864"/>
        <property type="gene ID" value="HMPREF0766_11581"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067342_0_0_10"/>
    <dbReference type="OrthoDB" id="324612at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023856">
        <property type="entry name" value="Bacillithiol_biosynth_YpdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04018">
        <property type="entry name" value="Bthiol_YpdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="322" mass="36056" checksum="7F1E3B86D4C41240" modified="2010-10-05" version="1">MVDLDILIIGAGPIGLACGIEAKAANLSYIIVEKGCLVNSLYNYPVNMTFFSSAERLEIGETPFVTTNPKPKRAEALEYYRRICQKFELNTHLFEEVLTVDPAESSTYIVSTNKATYRAKHIIVATGFYDIPMLLNVPGEDLPKVRHYYNDPHYYAGQHVIVVGASNSSIDAALETYRKGAKVTLVIRGHEVSPRVKYWVRPDIENRIAFKEIDVLYNSHIHSISEEAAEVSTPQGLITIKNDFVLALIGYRPDFGFLKKIGINVPEESPMIPEHNEETMETNMKGIYLAGVVCGGLNTHLWFIENSRVHATQIINHITSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKV7</accession>
    <name>D7VKV7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1080 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999562.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11626"/>
    <dbReference type="EnsemblBacteria" id="EFK58230">
        <property type="protein sequence ID" value="EFK58230"/>
        <property type="gene ID" value="HMPREF0766_11626"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7HW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073042_1_1_10"/>
    <dbReference type="OrthoDB" id="1452706at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1080" evidence="1">
        <location>
            <begin position="34"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="272" mass="30896" checksum="2BAADADC427C28D1" modified="2010-10-05" version="1">MKRNLFLYIWIALLTTGGCSVKKAKENTDTTTQEWKSLFNGKDINDWNVKIHHHDFGVNYGHTFRVQDGMIQVRYDEYGDFNEQYGHLYYKTPYSYYHLKLEYRFVGELHSGAPDYTLRNSGVMFHSQDPATMPREQDWPISVEMQFLGGLGDGKPRPTGNMCSPGTHVIYKGKIAASHCLNSTSKTYDGDQWVSAELIVLGDSLITHIIEGDTVLQYSKPQIGGGVANRYDPGIKIDGQLLKSGFIALQSEGQPVDFRNIRIKDLSSQYRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKW2</accession>
    <name>D7VKW2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11631</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999570.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11631"/>
    <dbReference type="EnsemblBacteria" id="EFK58235">
        <property type="protein sequence ID" value="EFK58235"/>
        <property type="gene ID" value="HMPREF0766_11631"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2956">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_3_0_10"/>
    <dbReference type="OrthoDB" id="758760at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="26"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="361"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="490" mass="55031" checksum="418C4CB601604FB4" modified="2010-10-05" version="1">MFYAKNIFKIAVLAVLITGFCSCRKDFLEVVPKGAAIASKTSDYERLLNHSFLSSMYRSTNVVMSDELAAYKPFLILGSGYTVISDLKAFEYQDDIYLPTEEDSELSDLVQQLYTYNKVINEVMASKEGNEQYKKALRAEALAGRAWVNFTLVNFYGKPYNAATAAVDPGIPLITVADVTQTVFERLSVQAAYDLIIADLTEAIPSLSPRIISRFRMSQSAGETILGKVYMNMQQFDKALPLFASAISKLSNADIPVRLYDFNTTFGPGGAFYPINPYTGPNRLNLAIDEEVLYLKRQYDFYNYFLSGFPINPQTVKLYSPADLRLNFFTKSPFGAPGVTYPLNMMRGYGRFNNMGVSVPDMILLKAECESRAGSLPNAINDLLSLRKKRMKNTVAGAADIPSNVAGDKVALTKYILEERIREYATTGQRWWDMRRLSVDDTYKSTVGMVHHVYDTAGNIIKSYPLKPERLTFRYPLNIMNSNPSMPQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKX8</accession>
    <name>D7VKX8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAH family protein</fullName>
            <ecNumber evidence="2">3.7.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fahA3</name>
        <name evidence="2" type="ORF">HMPREF0766_11647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999609.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11647"/>
    <dbReference type="EnsemblBacteria" id="EFK58251">
        <property type="protein sequence ID" value="EFK58251"/>
        <property type="gene ID" value="HMPREF0766_11647"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_5_2_10"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="203" mass="23108" checksum="EFDBE00057DE23DB" modified="2010-10-05" version="1">MKIIAVGRNYIDHAKELNNPVPKTPVIFMKPDTALLKDNKDFYYPEFSKDIHYEVEVVLRICKEGKHVSPKFAHTYYDAIGLGIDFTARDIQQQHKEKGLPWELAKSFDGSAVISPFILKDTFSDPAQLSFSLQKNKEIVQSGHTKDMIFSYDQLIVFISQYITLRKGDFIYTGTPAGVGPVSIGDRLEGFMEEKSMFTCQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKZ2</accession>
    <name>D7VKZ2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Outer membrane protein transport protein, Ompp1/FadL/TodX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">fadL</name>
        <name evidence="9" type="ORF">HMPREF0766_11661</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OmpP1/FadL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999651.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11661"/>
    <dbReference type="EnsemblBacteria" id="EFK58265">
        <property type="protein sequence ID" value="EFK58265"/>
        <property type="gene ID" value="HMPREF0766_11661"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035981_2_0_10"/>
    <dbReference type="OrthoDB" id="620166at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005017">
        <property type="entry name" value="OMPP1/FadL/TodX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35093">
        <property type="entry name" value="PTHR35093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03349">
        <property type="entry name" value="Toluene_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107260" evidence="8">
        <location>
            <begin position="19"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK58265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="407" mass="43985" checksum="44625A9A8E375EDF" modified="2010-10-05" version="1">MKKLLFALLCASPSLLWAQGSQVNLQSPKSVGMGGAGSAYFIDEASIFYSPGALAKMDHNAVMVAGNAVMYKSAFRESGSSVVNHTKSQISPPFSLFAAFGPKNSWWKAGIGVYTPYGGGVDWGTEWAGRFSLVSLSLRAIYIQPTLSFKLTDNFSIGGGFVYNIGSVDLENSVPVFFPDGRPGLATLKGTGTGTGYNVGVHYNLEDDFAISLSYRSKVVTKLKDGDALFDVPESVRSSFPEGNTFTSELPLPSTFALGIAFPLSEKVKVAVDGTLIGYSIYKELNFDYKENTAALQDTRSAKNYVNAGSVKAGLEYLASEKLQLRVGGGYMATPVQANYVYPETPDNTRYLISGGFTFHPSKKFDVTGSFAYQRIMPREANNVESHLSGTYKTNIFAPGVSVSYKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL20</accession>
    <name>D7VL20_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CbbQ/NirQ/NorQ/GpvN family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999725.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11689"/>
    <dbReference type="EnsemblBacteria" id="EFK58293">
        <property type="protein sequence ID" value="EFK58293"/>
        <property type="gene ID" value="HMPREF0766_11689"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133108_0_0_10"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="115" mass="13279" checksum="E3F6A5BFB6ECCF1B" modified="2010-10-05" version="1">MDGRKFAEEWIHSWNTHNLEDILSHYSDDIEITTPMIKLALGVDNGSLKGKDLVADYWQKALNKLPDLHFELYDVTVGVNSVALYYKSVMNKKAIEVMFFDEYGKVNKMFAHYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL41</accession>
    <name>D7VL41_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PCMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999753.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11710"/>
    <dbReference type="EnsemblBacteria" id="EFK58314">
        <property type="protein sequence ID" value="EFK58314"/>
        <property type="gene ID" value="HMPREF0766_11710"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z913">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058034_0_0_10"/>
    <dbReference type="OrthoDB" id="796318at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025112">
        <property type="entry name" value="PCMD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038653">
        <property type="entry name" value="Put_CMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13201">
        <property type="entry name" value="PCMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCMD" evidence="1">
        <location>
            <begin position="123"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="370" mass="40757" checksum="B0C17A075FCCA00A" modified="2010-10-05" version="1">MLNKIVIISIAVSMFLLNSCIKDEPLNMEADITAVYLEQGSLITEPLITNNSVTIYVKPKEAGSPDYKLKFDLSPGATITTDVGQNTDKVVTYKVTSQDKRFEKKYLVSIIEVTDGFVPSKFDFENFRTDETNKYHEFFDIVNNNSFNNWSSGNPGFAISLFGEKKPEMYPTRATDKSRSGKSAALLETKSTGPFGAMFGKPIAAGNLFIGVFDVTMALASPLKATRFGLPYNNVPKTFEGYYRYTPGKQLINSASKPVEGEDECTIYAVFYNIDDLMKETQKSYLSGENVWTSKSVVATAKLESGKATAGEGFTKFSIPFKYVKDVNIADVNKLKYGIAIVMSASKDGDNFQGAIGSTLIVDDVQIITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL95</accession>
    <name>D7VL95_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999904.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11764"/>
    <dbReference type="EnsemblBacteria" id="EFK58368">
        <property type="protein sequence ID" value="EFK58368"/>
        <property type="gene ID" value="HMPREF0766_11764"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002543_0_0_10"/>
    <dbReference type="OrthoDB" id="1729410at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107012" evidence="1">
        <location>
            <begin position="22"/>
            <end position="1118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1118" mass="114537" checksum="D0F536E6CBE09E86" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLM1</accession>
    <name>D7VLM1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter, MotA/TolQ/ExbB proton channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0766_11891</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000225.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11891"/>
    <dbReference type="EnsemblBacteria" id="EFK58494">
        <property type="protein sequence ID" value="EFK58494"/>
        <property type="gene ID" value="HMPREF0766_11891"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0811">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053325_4_3_10"/>
    <dbReference type="OrthoDB" id="1796180at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="8">
        <location>
            <begin position="132"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK58494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="276" mass="29049" checksum="EB79633E2DC7BBEC" modified="2010-10-05" version="1">MANAPKTTSPAKQESGNSGSLFASLAIIICFIVGFVVWKYVMGSPSNFQENNPENQPLPGNYLGMVYHAGAIVPILIGLFLMVWVFSIERLIVINKASGTGNVGNFVRKVQTLINGGNIDTAIAECDKQKGSVANVIKAGLLKYKDVSANPGLDSEKSALAIQKEIEETTALEMPMLEKNLNVIATLVSIGTLTGLLGTVTGMIKAFSALATGGAPDSAKLANGISEALINTATGIATSTFAIVMYNILTAKIDKLTYSIDEAGFSIVQTYAANHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLN4</accession>
    <name>D7VLN4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RDD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11904</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000264.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11904"/>
    <dbReference type="EnsemblBacteria" id="EFK58507">
        <property type="protein sequence ID" value="EFK58507"/>
        <property type="gene ID" value="HMPREF0766_11904"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054176_2_0_10"/>
    <dbReference type="OrthoDB" id="1974702at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="19"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="242" mass="27374" checksum="DD65DE52CDE2318E" modified="2010-10-05" version="1">MNKLLINTPQNVKFEYNLATLGARIIAFGIDQLIVIAYVILAVLILKYSGAAFLSDSWTTMGLYSLFMLPAFFYPFVMETVLSGQTLGKKIMKIKVVKIDGTRATAYQYFIRWVCSIVDIFLCMGALGMSSIILSKKGQRIGDLAADTTVISTQTNTQLSHTLFAEITAERAVTYPQVVKLSDQDANTIKDVFNKGFKRKDYNIIWALSARLEQILGIQRDRNPEEFIDIIIKDHYTIFRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLN6</accession>
    <name>D7VLN6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M16 inactive domain protein</fullName>
            <ecNumber evidence="3">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000268.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11906"/>
    <dbReference type="EnsemblBacteria" id="EFK58509">
        <property type="protein sequence ID" value="EFK58509"/>
        <property type="gene ID" value="HMPREF0766_11906"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_3_2_10"/>
    <dbReference type="OrthoDB" id="1188251at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="1">
        <location>
            <begin position="23"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="2">
        <location>
            <begin position="170"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="414" mass="46922" checksum="59773258B62AB82A" modified="2010-10-05" version="1">MTTMEYEIIRLSNGIRIVLYPQQTPITHTCLLINAGSRDEENGKFGVAHFIEHLLFKQTERRNTNQILNRLETVGGDLNAYTTKEYTCIHASVLNPYLDRALDLFEDIIFHSTFPDIEMEKEKSVIVDEMASYLDSPEDAIIDDFEDILFADSGLGHNILGIEDQLIGLQKSDILRFMQGNYNTNDIVIGITGDYKKMQIEKLVNRIFGQIETAVIQRDRTLVPVHAPQHIRVEKPINQVHYMLGTQAYGIRDERKTGLLLLNNMLGGLGMSSILNLSIREKYGIAYTIESNYSMFSDTGIFSIYLGTDEEKAKKAVSLVFKELNRLKAHGLTAAQLQKAKNKFKGQIALAEENRMSMIIAVAKNIMDYDRVITLDEVFQKIDEVSADAAKEILEDIFDTDKMTSLSFVPSEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLS2</accession>
    <name>D7VLS2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_11942</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000007">
        <property type="protein sequence ID" value="EFK58224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000968.1">
        <property type="nucleotide sequence ID" value="NZ_GL379775.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11942"/>
    <dbReference type="EnsemblBacteria" id="EFK58224">
        <property type="protein sequence ID" value="EFK58224"/>
        <property type="gene ID" value="HMPREF0766_11942"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_10"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="127"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="127"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="226" mass="25980" checksum="1BC7DE757F110DF4" modified="2010-10-05" version="1">MDILIIEDDLRVAQLIERAVREQGFQTMLAYDGMSGKKLALQHDFSLIITDIILPKIDGLDLCKEVRQLKPDLPIIMLTALGTTDNKVEGFDAGADDYLVKPFEMRELIARIRALLKRKDQSASVASFVLKYHDLEMNLNTKMVKRAGIEIELTPKEFNLLQYFLSHPEKVLSRSDIAENVWETHFDTGTNFIDVYINYLRKKIDKDFNHKLIHTKPGMGFILRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM23</accession>
    <name>D7VM23_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001226.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12020"/>
    <dbReference type="EnsemblBacteria" id="EFK58028">
        <property type="protein sequence ID" value="EFK58028"/>
        <property type="gene ID" value="HMPREF0766_12020"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZW22">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2095310_0_0_10"/>
    <dbReference type="OrthoDB" id="2028268at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="120" mass="14202" checksum="E0A41BD1BE4EE741" modified="2010-10-05" version="1">MLKKKNTKINPYLIISVVLLLIIWLMMGVSQDDEFNEYNVFVKYRPTTQLYFKSPLGMDDMPPDFPEKLRAKQAIYDDFILTRHWSDHEVVSITGRILVLITPVFLFIGIYKQIKNNYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM58</accession>
    <name>D7VM58_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001327.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12055"/>
    <dbReference type="EnsemblBacteria" id="EFK58063">
        <property type="protein sequence ID" value="EFK58063"/>
        <property type="gene ID" value="HMPREF0766_12055"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169010_0_0_10"/>
    <dbReference type="OrthoDB" id="2074658at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="112" mass="12324" checksum="AB91646D6362AA25" modified="2010-10-05" version="1">MEKETMVATIIVAFCLSTFLSLYFYWLARHKERMALIERGMDLSDFYNNKLKGSNWLKVGVVVVASAVGLLIVGIISESKVEIHSDAIPVAIIGIFGGAGMIVANYLDKRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMF9</accession>
    <name>D7VMF9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, alpha/beta domain protein</fullName>
            <ecNumber evidence="2">3.1.1.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">catD</name>
        <name evidence="2" type="ORF">HMPREF0766_12156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.24" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001502.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12156"/>
    <dbReference type="EnsemblBacteria" id="EFK58164">
        <property type="protein sequence ID" value="EFK58164"/>
        <property type="gene ID" value="HMPREF0766_12156"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_4_10"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047570">
        <property type="term" value="F:3-oxoadipate enol-lactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="33"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="278" mass="31083" checksum="3B41784E5432BC0E" modified="2010-10-05" version="1">MTERNFKSSKIRIGDISISYYIKPALTSEPTETIIFIHGFPFNKKTWKAQLESLADNVTGIAVDVRGHGNTTAGHGFFSIDVFAKDLVVFIKKLDIEQVTLCGISMGGYIALRAQQLIPKRIKGLILCDTHARADDNKGKQKRFDSIQAILQYGRRPFAIGFVENVFHKDTISNNPEAVELIKSSIRRNSISSICATQLALASRTDTRDTLDAIDIPTLLIRGASDTITPKELMEELDTAIPQASYVELENAGHLPNLEQPERFNSLLHEFLRNLQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VML6</accession>
    <name>D7VML6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rfbD</name>
        <name evidence="4" type="ORF">HMPREF0766_12236</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992672.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12236"/>
    <dbReference type="EnsemblBacteria" id="EFK57163">
        <property type="protein sequence ID" value="EFK57163"/>
        <property type="gene ID" value="HMPREF0766_12236"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045518_2_1_10"/>
    <dbReference type="OrthoDB" id="1076083at2"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="5"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="308" mass="34625" checksum="2BC01541956AA73B" modified="2010-10-05" version="1">MSKTTVLITGANGFLGQKLTDLLSADSRYKVIATSKGENRNPNKADYTFRQLDILDTEALDNILQHYKPASIIHTAALTSVEACEEQPELCQRLNIDVVAQLGRYAALNNSYIVHLSTDFVFDGKNGPYKEDDPTNPLSAYGRSKVNSESALALTQCKYAVLRTILVYGIIADEKRSNLVLWAKDKLSKQEAIKVVNDQWRMPTFVDDLARACKSAIEKQPTGIFHISGEEMMSIAEAVYTIADFWNFDRTYISEISAATIGQTDNRPRKTGFDLSKAKRLLDYRPTPFRESLHLIDQQFKTFRPLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN19</accession>
    <name>D7VN19_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">START_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992915.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12389"/>
    <dbReference type="EnsemblBacteria" id="EFK57316">
        <property type="protein sequence ID" value="EFK57316"/>
        <property type="gene ID" value="HMPREF0766_12389"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129812_0_0_10"/>
    <dbReference type="OrthoDB" id="1498264at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045736">
        <property type="entry name" value="START_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19569">
        <property type="entry name" value="START_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START_2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="125" mass="15019" checksum="CD634209BEF88EEB" modified="2010-10-05" version="1">MEEKVKFQREYIINSSPRILFPFLEEANALAQWFADEVHYRDNTYEFIWDNESHKAKLIASKENKSVKFKWLDDEPYFFEMEINQDELTNDVALSIVDFAKEDNLEDRKKIWDNQIEYLQSVIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN49</accession>
    <name>D7VN49_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992958.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12419"/>
    <dbReference type="EnsemblBacteria" id="EFK57346">
        <property type="protein sequence ID" value="EFK57346"/>
        <property type="gene ID" value="HMPREF0766_12419"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1776261_0_0_10"/>
    <dbReference type="OrthoDB" id="2164324at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="146" mass="16408" checksum="057B9AF1EE16D26F" modified="2010-10-05" version="1">MTNFEIITSILAFGTLLTGTGTIILAWITNETNKKIAKRQGVIDLHNAWNNIRSISKSDLITPDIVNATNALSLTASLWNNSVMEKNILYQSYWSNFKNLYDTLASIDELVPGHNFSCKSLLTADIKSVYKEMEKIELSKVSKTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNA1</accession>
    <name>D7VNA1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993022.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12471"/>
    <dbReference type="EnsemblBacteria" id="EFK57398">
        <property type="protein sequence ID" value="EFK57398"/>
        <property type="gene ID" value="HMPREF0766_12471"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_9_0_10"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="191" mass="22257" checksum="F928823B9FB9825C" modified="2010-10-05" version="1">MHDQFLKLISQTVRLSEQEIELCFQYLEPVHYPKNKILEAEGKIPRYLYFVVSGFVRLFYYNEKGDEVTTHINCPPGFITAYANFANQTPSDENLECVTECELLRIKKSALDDLVQQSPAFRDFSIIVLQQSLAYNERRAKDMAVLSAEQRYLKLLDEQPELLHNIPMQYIASFLGMNAKSLSRIRRKIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNE2</accession>
    <name>D7VNE2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OmpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12512</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993079.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12512"/>
    <dbReference type="EnsemblBacteria" id="EFK57439">
        <property type="protein sequence ID" value="EFK57439"/>
        <property type="gene ID" value="HMPREF0766_12512"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016890_14_0_10"/>
    <dbReference type="OrthoDB" id="1619550at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="3">
        <location>
            <begin position="157"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="27"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="301" mass="33756" checksum="4B791545FDEFD3CA" modified="2010-10-05" version="1">MMKQSVLPISILLSGLFLTSCVSSGKFKSLQTDYDKLQTEHRDLAQKYQQGQLDLTEGRTRIKSLEEQLAYEKANNAQLKEAYANLQKTLDNSINQNSQGNVNISKLVDEINASNKYIQHLVNTKNKSDSLNMVLTNNLTRSLSREEMKDVDVQVLKGVVYISLSDNMLYKSGSYEISDKAGETLSKIAKIIQDYKDYEVLIEGNTDTDPISKTNIRNNWDLSTLRASSVVQALQNTYGVDPKRLTAGGRGQYNPIADNSTAAGKMKNRRTQIIITPKLDQFMELIDKAPETENNNMTEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNL9</accession>
    <name>D7VNL9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conjugative transposon TraJ protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">traJ</name>
        <name evidence="3" type="ORF">HMPREF0766_12589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993175.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12589"/>
    <dbReference type="EnsemblBacteria" id="EFK57516">
        <property type="protein sequence ID" value="EFK57516"/>
        <property type="gene ID" value="HMPREF0766_12589"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8G6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061368_0_0_10"/>
    <dbReference type="OrthoDB" id="687513at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022393">
        <property type="entry name" value="Conjugative_transposon_TraJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012424">
        <property type="entry name" value="Conjugative_transposon_TraJ_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07863">
        <property type="entry name" value="CtnDOT_TraJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03782">
        <property type="entry name" value="Bac_Flav_CT_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="CtnDOT_TraJ" evidence="2">
        <location>
            <begin position="271"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="331" mass="36688" checksum="4FA723D173F4ECB7" modified="2010-10-05" version="1">MEWDNLHELLRSLYDDMMPLAGDMAAVAKGLAGLGALFYVALKVWQALSRAEPIDMFPLLRPFALGLCIMFFPTIVLGTINAVLSPVVVGTHQILEDQVIDLNKLQQQKDQLEYEAMVRNPETAYMVSDEEFDKKLDELGWSPSDIGTMAGMYMDRQAYKIEKAIKDWFRNLLEILFQAAALVIDTIRTFFLIVLSILGPIAFAISVWDGFQSTLTQWLTRYVSVYLWLPVSDLFSSMLARIQSLILERDIAMLADPTYIPDTSNTVYIIFMIIGIIGYFTIPTVTGWVIQAGGAGNFTRNVNSTAMKAGNIAGAGAGSTVGNIGGKLMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNM2</accession>
    <name>D7VNM2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conjugative transposon protein TraF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">traF</name>
        <name evidence="2" type="ORF">HMPREF0766_12592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993179.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12592"/>
    <dbReference type="EnsemblBacteria" id="EFK57519">
        <property type="protein sequence ID" value="EFK57519"/>
        <property type="gene ID" value="HMPREF0766_12592"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141616_0_0_10"/>
    <dbReference type="OrthoDB" id="1987642at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025407">
        <property type="entry name" value="DUF4133"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13571">
        <property type="entry name" value="DUF4133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="110" mass="12534" checksum="7B30E1AF1738760C" modified="2010-10-05" version="1">MNSYNINKGIGRTVEFKGLKAQYLFIFAGGLLGTLIFVMILYMAGVSNYVCLFLGAGGASLIVWQTFSLNRKYREHGLMKVGARKRHPRYIICRKPVRRYLKFTPKPKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNR7</accession>
    <name>D7VNR7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12637"/>
    <dbReference type="EnsemblBacteria" id="EFK57564">
        <property type="protein sequence ID" value="EFK57564"/>
        <property type="gene ID" value="HMPREF0766_12637"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1884463_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="135" mass="15367" checksum="6E807CA01B3B7F8A" modified="2010-10-05" version="1">MLPRNFFGNRADIQSHLRRCNFAVPDYIKFFPVVELCGNLYVQFPGFLSGKYLRVLDRLMEEDLVHKVVNVDGGVGYASCHNCEVVHNHNHLHFSCQKCKSVTCIEDVQPLFKLPKGYKISEVNFTVSGLCPQCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNT4</accession>
    <name>D7VNT4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993277.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12654"/>
    <dbReference type="EnsemblBacteria" id="EFK57581">
        <property type="protein sequence ID" value="EFK57581"/>
        <property type="gene ID" value="HMPREF0766_12654"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147365_1_0_10"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="136" mass="15834" checksum="15C11BC81747DF58" modified="2010-10-05" version="1">MQEEDKVHVLETLEENHQGRNAQRIRIYLGIKQEVLANELGMSQPQISAIEREAVLEPEMLERFAFALGVTPDLIKKFDVERAIYNINSYKDSTVQHGENSTQNINPLDKVVELYERLLQSEREKLELFINQKNHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNY9</accession>
    <name>D7VNY9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_12709</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993367.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12709"/>
    <dbReference type="EnsemblBacteria" id="EFK57636">
        <property type="protein sequence ID" value="EFK57636"/>
        <property type="gene ID" value="HMPREF0766_12709"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_4_1_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014327">
        <property type="entry name" value="RNA_pol_sigma70_bacteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02985">
        <property type="entry name" value="Sig70_bacteroi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="130"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="198" mass="23396" checksum="BA095D9BA25B5ACE" modified="2010-10-05" version="1">MGRITLFNEKNLLLKLKNGDRHAFEQLYHFYKNHITGHLFYIFKSEELTQDVTQETFITVWENRFQLHADKSFKSYLYTIATNKAYDLLRKANLDKQLYDKVSSFIDSSSDEIYETLFVKQRSEQLHQILAQLPSQQRLVFQMAKLDGYSYEEIARALGISQHTVNTHIKRANIFLKNQILKSPELFVLIYALFLEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP23</accession>
    <name>D7VP23_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6067 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12743"/>
    <dbReference type="EnsemblBacteria" id="EFK57670">
        <property type="protein sequence ID" value="EFK57670"/>
        <property type="gene ID" value="HMPREF0766_12743"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8VG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_297501_0_0_10"/>
    <dbReference type="OrthoDB" id="47266at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045711">
        <property type="entry name" value="GH123_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19543">
        <property type="entry name" value="DUF6067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107749" description="DUF6067 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6067" evidence="2">
        <location>
            <begin position="32"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="992" mass="113227" checksum="636849DA461619BE" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP50</accession>
    <name>D7VP50_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993472.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57697">
        <property type="protein sequence ID" value="EFK57697"/>
        <property type="gene ID" value="HMPREF0766_12770"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031AIB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129316_0_0_10"/>
    <dbReference type="OrthoDB" id="1885155at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107481" evidence="2">
        <location>
            <begin position="20"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="176" mass="19849" checksum="6CDE87088276DA88" modified="2010-10-05" version="1">MQRYLIICLLFVLPFLAVAQQNTIENFTIKENLTQNGKLAIVALDTAEHANERINGTYAFSLNGLKQDLIFHNGVAVATNTIESSTFVFFKHKNQEHSLGKLYYIFKSDKGLNPVKISGLILLVVPCIILLIAYTFRRFLVTAVILALVYVFFNYSQGLSISNLLESIFMGIKSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPC5</accession>
    <name>D7VPC5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rod shape-determining protein MreD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreD</name>
        <name evidence="2" type="ORF">HMPREF0766_12845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993612.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12845"/>
    <dbReference type="EnsemblBacteria" id="EFK57772">
        <property type="protein sequence ID" value="EFK57772"/>
        <property type="gene ID" value="HMPREF0766_12845"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50315DF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125324_1_0_10"/>
    <dbReference type="OrthoDB" id="1714149at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="174" mass="20159" checksum="C351BF314B813339" modified="2010-10-05" version="1">MGRTVLINFLRFVVLILLQVFLFKNIGYYNLASPFPYILIIFLLPIGLPNLLLYVLAFLTGLTIDVFYDSLGVHAAACVALAWYRIFFHNITLEVDMKESYLTPSLGEMGFKWFLSYTFFGILVHHTVLYILEVFSFYQFQYTLLSIGLSCIFTLVIILLSGLLFFRKKTRYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPD5</accession>
    <name>D7VPD5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">marR</name>
        <name evidence="2" type="ORF">HMPREF0766_12855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993624.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12855"/>
    <dbReference type="EnsemblBacteria" id="EFK57782">
        <property type="protein sequence ID" value="EFK57782"/>
        <property type="gene ID" value="HMPREF0766_12855"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_18_6_10"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="150" mass="17660" checksum="705E2E2B4A246A61" modified="2010-10-05" version="1">MQNEKFNEYSFILDRTAKKVKQYAQSSFTEKGFDITVDQWTIIKTLFEHPDLLQKELAEKCGKDQPTLTRIVDLLIKKGLAERHNHPTDRRSLYLKLTDLGISKVQSLTPHITQIRTKAWDNLTDEDFKHFTRILNKIHDNLNIESYDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPF4</accession>
    <name>D7VPF4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993658.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12874"/>
    <dbReference type="EnsemblBacteria" id="EFK57801">
        <property type="protein sequence ID" value="EFK57801"/>
        <property type="gene ID" value="HMPREF0766_12874"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016599_1_2_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107761" evidence="1">
        <location>
            <begin position="19"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="777" mass="87934" checksum="53E3F1E86A67C711" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPJ3</accession>
    <name>D7VPJ3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Auxiliary transport protein, membrane fusion protein (MFP) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_12913</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993756.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12913"/>
    <dbReference type="EnsemblBacteria" id="EFK57840">
        <property type="protein sequence ID" value="EFK57840"/>
        <property type="gene ID" value="HMPREF0766_12913"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_15_1_10"/>
    <dbReference type="OrthoDB" id="1680841at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043602">
        <property type="entry name" value="CusB_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00529">
        <property type="entry name" value="CusB_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CusB_dom_1" evidence="3">
        <location>
            <begin position="15"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="50"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="134"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="364" mass="39773" checksum="DAB334B40435CC28" modified="2010-10-05" version="1">METNNKESKKSNKKFVIILVVLVLLGGGYGTYKYLHGQAHETTDDAQVDKNMSPIIPRVGGYVSKVFVKDNDIVKKGDTLFTIEPQDYLVKVQEAQAALLAAESSLEVSKADVFASSANVAISDASIKSNVGSVDAAKIRAEQANNDYVRYSNLYNNHSITKQQYEQALTAKLEAEKQVEILQQQRNASASQRNAVVSKTTVASKQTSVAQANIERAKAVLDAANLSLSYTTVVASVDGQVSNIKIQPGQMINPGQSLFYIVDNSETWVVANFKETQLNKMRPGQKVTIKIDAFPDTEFEGEINSFSPATGSRFSLLPPDNATGNFVKTVQRLPVKIRLTDKNTTDKIALLRPGMNADVDVHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPL9</accession>
    <name>D7VPL9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12939"/>
    <dbReference type="EnsemblBacteria" id="EFK57866">
        <property type="protein sequence ID" value="EFK57866"/>
        <property type="gene ID" value="HMPREF0766_12939"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090004_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024453">
        <property type="entry name" value="Peptidase_C92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05708">
        <property type="entry name" value="Peptidase_C92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="216" mass="24084" checksum="35E326AEAE1982DE" modified="2010-10-05" version="1">MKTLLATFCLSLTLTLSFGQKSGTEVTLRDIQSGDLIFVGAQQQDLSGAINRVTQTSQSVSFDHIGMIEMTKDSVFVLHASSTKGSVRQEIHQFYEEQQNGGNALVLYRLKDPFISSIPAALKSAGAMLGKPYNRSYILNDSCYYCSDFIYRAFEKNQIFSLAPMTFINPETGKTDDFWKAFYKKQNLEVPEGKPGCNPNGMAASEKLNRLGRLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPM1</accession>
    <name>D7VPM1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glyoxalase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12941"/>
    <dbReference type="EnsemblBacteria" id="EFK57868">
        <property type="protein sequence ID" value="EFK57868"/>
        <property type="gene ID" value="HMPREF0766_12941"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140151_0_0_10"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="129" mass="14856" checksum="AEC1A43CB3898238" modified="2010-10-05" version="1">MQKTNYIPMKITGGKNIAIKVPVSKYEETVGFYTRILGLQTSEILTPEHPTVKKSTKVAFGENTLWLDATEEVSRTEAWFELLTDNLAETEEHLQRENITFEDDLEQIPAHMHWIKDPIGNVFILKESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPR2</accession>
    <name>D7VPR2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993862.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12982"/>
    <dbReference type="EnsemblBacteria" id="EFK57909">
        <property type="protein sequence ID" value="EFK57909"/>
        <property type="gene ID" value="HMPREF0766_12982"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1037887_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107772" evidence="1">
        <location>
            <begin position="24"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="268" mass="30046" checksum="1C01356349B31338" modified="2010-10-05" version="1">MNRKIVCFLLLICVLVITGCRKAEEVNSFTALSTVQFTNKQADGYEIKIGKETIPFNILKKIIKTDSVEVSVVSLASKAEVLKQYIKLEDNINTFTLLKMDPADEQTVVLMKGNGGIEGVEPEPGKIKVKFVNYNKELASNAAAIHLVFQELKEFDFGMFMSVYYDISTDTVFNVSRKVPTDYTALPVKSPQVRSTDYVGRFLVLKADKKPLLKDGEPVYLYLESSNTSAGIFISTIPDGIISKKEDYFDTWTPSPGWAYPFSNFLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPU8</accession>
    <name>D7VPU8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ragA</name>
        <name evidence="7" type="ORF">HMPREF0766_13018</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993910.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13018"/>
    <dbReference type="EnsemblBacteria" id="EFK57945">
        <property type="protein sequence ID" value="EFK57945"/>
        <property type="gene ID" value="HMPREF0766_13018"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="115"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="404"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1006" mass="110931" checksum="B88788E3CACAC992" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ00</accession>
    <name>D7VQ00_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_13054</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993968.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13054"/>
    <dbReference type="EnsemblBacteria" id="EFK55851">
        <property type="protein sequence ID" value="EFK55851"/>
        <property type="gene ID" value="HMPREF0766_13054"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016232_0_0_10"/>
    <dbReference type="OrthoDB" id="956262at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019690">
        <property type="entry name" value="DUF2569"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024618">
        <property type="entry name" value="DUF3857"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10754">
        <property type="entry name" value="DUF2569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12969">
        <property type="entry name" value="DUF3857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="660"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="701"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="750"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="783"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3857" evidence="4">
        <location>
            <begin position="74"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="3">
        <location>
            <begin position="291"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="857"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK55851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="878" mass="101400" checksum="4FE71FDE1FFA9CB7" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ14</accession>
    <name>D7VQ14_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleoside transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_13068</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993987.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13068"/>
    <dbReference type="EnsemblBacteria" id="EFK55865">
        <property type="protein sequence ID" value="EFK55865"/>
        <property type="gene ID" value="HMPREF0766_13068"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013133_1_2_10"/>
    <dbReference type="OrthoDB" id="791272at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004740">
        <property type="entry name" value="Nuc_H_symport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03825">
        <property type="entry name" value="Nuc_H_symport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="164"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK55865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="414" mass="46355" checksum="79DF0F3FD757010F" modified="2010-10-05" version="1">MSTGIKIKLSFMMFLEFFIWGAWFVTLGTFLSKSLNATGLESANVFSTQSWGAIVAPFIIGMIADRFFNAERILGVLHIVGAFLMYQMYQSTSVSEFYPYVLGYMLLYMPTLSLVNSVSFRQMKNPEKEFSIIRIFGTLGWIVAGLAISYIFKWDAGDGLLKNTFLMAGIASLVLGLFSFTLPKTPPVKIEQTEKATVGQILGLDAVKLLKDKNFLLFFISSILICIPLAFYYQNANVFLSEINLENPTGKMTIGQISEVLFLLLLPVFFTRFGFKKTILVGMLAWAVRYLMFAYGNAGDLTFMLITGIALHGICYDFFFVSGQIYTDNKAGAKYKSSAQGLITLATYGVGQLIGFWVAGYVSDMYIDLKSTDVALFWNKVWVIPAGIAVVVFLFFLIFFKDEKIESTKETETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ53</accession>
    <name>D7VQ53_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WD40-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994049.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13107"/>
    <dbReference type="EnsemblBacteria" id="EFK55904">
        <property type="protein sequence ID" value="EFK55904"/>
        <property type="gene ID" value="HMPREF0766_13107"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010614_0_0_10"/>
    <dbReference type="OrthoDB" id="385673at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1025" mass="115706" checksum="05838FFAFF222B2E" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ97</accession>
    <name>D7VQ97_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="6">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">lysS</name>
        <name evidence="9" type="ORF">HMPREF0766_13151</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6 7">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994116.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13151"/>
    <dbReference type="EnsemblBacteria" id="EFK55948">
        <property type="protein sequence ID" value="EFK55948"/>
        <property type="gene ID" value="HMPREF0766_13151"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008255_6_0_10"/>
    <dbReference type="OrthoDB" id="63621at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="187"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK55948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="572" mass="65127" checksum="3DFF683C7572C924" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQC3</accession>
    <name>D7VQC3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MazG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mazG</name>
        <name evidence="2" type="ORF">HMPREF0766_13177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994183.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13177"/>
    <dbReference type="EnsemblBacteria" id="EFK55974">
        <property type="protein sequence ID" value="EFK55974"/>
        <property type="gene ID" value="HMPREF0766_13177"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3956">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038356_0_1_10"/>
    <dbReference type="OrthoDB" id="1099129at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00444">
        <property type="entry name" value="mazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="36"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="268" mass="31087" checksum="83C09E86E742741B" modified="2010-10-05" version="1">MAHIPPAPQHSPATAFQRLLDVLYTLRVECPWDKKQTMESLRHLTIEEMYELTDAILDEDYPEIKKELGDVMMHLVFYARIAEEQNRFTLVDVLNAVCDKLINRHPHIYGDTNVEDDEQVKSNWEAIKLKEGNTSVLSGVPKGLPALVKAYRIQDKVRGVGFDWEDKKQVWEKVEEELAEFKAEFNIDNGEPIDAEKAEGEFGDLLFSLINYARHVGINPENALERTNKKFIKRFTYLEEKASENNQKLQEMSLAEMDVYWNEAKKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQD8</accession>
    <name>D7VQD8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">OsmC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994221.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13192"/>
    <dbReference type="EnsemblBacteria" id="EFK55989">
        <property type="protein sequence ID" value="EFK55989"/>
        <property type="gene ID" value="HMPREF0766_13192"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100275_4_0_10"/>
    <dbReference type="OrthoDB" id="1430018at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="133" mass="15018" checksum="ECCC77C36D1E38D4" modified="2010-10-05" version="1">MSREITVTIEQEKYTTTITDNIHTLIADEPAEVGGQDKGFAPTQLLLSSLGSCKVITVRMYADQKKWELDKVIVRLSSEVKRSVQQQTTYIKCHISFEGNLDDDQKKRLAIIADRCPVHKILSNPIVIDSNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQL1</accession>
    <name>D7VQL1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4466 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994370.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13265"/>
    <dbReference type="EnsemblBacteria" id="EFK56062">
        <property type="protein sequence ID" value="EFK56062"/>
        <property type="gene ID" value="HMPREF0766_13265"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_859591_0_0_10"/>
    <dbReference type="OrthoDB" id="1089595at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12106">
        <property type="entry name" value="PARMER_03128_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028072">
        <property type="entry name" value="DUF4466"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041873">
        <property type="entry name" value="PARMER_03128_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14725">
        <property type="entry name" value="DUF4466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4466" evidence="1">
        <location>
            <begin position="20"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="328" mass="35992" checksum="B2694D25C2754871" modified="2010-10-05" version="1">MKKLISYIGIVSMLTLFVTACKENSYQIPEAESGLHNDVIKRSMGPNVVGTNIEFAYAMALLPTEGKIVSATVEASIAGASGTYLDNKSYYTNNSGVDVGVQIGDPSVTSSTTTTVNFSRDTSAATLRYYYKIPEEARGKTVSFKFSAKASNGQTVTYNLGPYDIRKMDMKLDLVAKDAQACYISIADMAVYDAAFAAQNPDKIDLVYLYRVIPNIDFKHAVVAPSANAIYLPGVTLPAGVKNNTKLIKAWTVRDQQLARLQYGVFVDDLDLMQKDFADAPDFAVNVRNEGGLWVETADKKYRAYVYINSSTDATKELKISMKRLAMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQX0</accession>
    <name>D7VQX0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994511.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13374"/>
    <dbReference type="EnsemblBacteria" id="EFK56171">
        <property type="protein sequence ID" value="EFK56171"/>
        <property type="gene ID" value="HMPREF0766_13374"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046640_1_1_10"/>
    <dbReference type="OrthoDB" id="466535at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009362">
        <property type="entry name" value="YhcG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041527">
        <property type="entry name" value="YhcG_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17761">
        <property type="entry name" value="DUF1016_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06250">
        <property type="entry name" value="YhcG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1016_N" evidence="2">
        <location>
            <begin position="10"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="YhcG_C" evidence="1">
        <location>
            <begin position="169"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="337" mass="39586" checksum="750F5F009E13AE25" modified="2010-10-05" version="1">MATHHSVITDIKAIISRAKDSAIRAVDHQRTLMYWNIGQRIFEEEQDGKDRADYGKYLTEYIAQELEPEFGSGFSKRQIELFRQFYRVFPIANTLYSQLSWSQYKLVIRLDNTDQREFYIAETIKNNWTVRQLERQIYSNLYERLLMSNDKESVLAVAKKEKLPSDASQIIKDPMILEFLGLKRENAYYERDLETAILTHLQEFLLELGNGFSFVARQKRIHIEGDEFFLDLVFYNRLLQCFVIVEIKTTKLTHQDIGQLQMYVNYYDRIEKLDHENPTIGILLCANKNDAVVKFTLPEGQKQIIASQYNLYLPTAQQLLDEMNKELESFKGKADGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR12</accession>
    <name>D7VR12_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994571.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13416"/>
    <dbReference type="EnsemblBacteria" id="EFK56213">
        <property type="protein sequence ID" value="EFK56213"/>
        <property type="gene ID" value="HMPREF0766_13416"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_1_0_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="3">
        <location>
            <begin position="235"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="2">
        <location>
            <begin position="510"/>
            <end position="1151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1152" mass="129485" checksum="FB759BB412E04B6B" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR24</accession>
    <name>D7VR24_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PQQ enzyme repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994590.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13428"/>
    <dbReference type="EnsemblBacteria" id="EFK56225">
        <property type="protein sequence ID" value="EFK56225"/>
        <property type="gene ID" value="HMPREF0766_13428"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056358_0_0_10"/>
    <dbReference type="OrthoDB" id="302683at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011964">
        <property type="entry name" value="YVTN_b-propeller_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02276">
        <property type="entry name" value="beta_rpt_yvtn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107179" evidence="2">
        <location>
            <begin position="34"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="351" mass="37502" checksum="ACCA36244EE37D45" modified="2010-10-05" version="1">MYNFTKPHIFKKEILIASSFAFAFLAWGHSASAQTVVKSSAAGKGVYEAVVNEQDGFIYVTSAGSRTQPGGAIYKIHPESLAITDSILMKENPPFGLGINHKTQTLYTTNTRTHSVSAVDIKTGKVIATFNNGKDKSHTREVLVDEDNNLIYISDVGDPSSIWVIDGKTNTYLHSIENTGKTTTGMVLNDRKDKMYITNMGTNEVAVIDLKSHKVEKSFPSGGESPVNLVADGNHIFVANQKSGTITVLDAASGQILKSIPTGDGAIGISYDKKNNRIYSANRQTGTTTVIDAATYAVLADLPTGSHPNNVKVSPQTGAAYVINKAKGGRPVEGQPALPADTNGDTITLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR98</accession>
    <name>D7VR98_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994682.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13502"/>
    <dbReference type="EnsemblBacteria" id="EFK56299">
        <property type="protein sequence ID" value="EFK56299"/>
        <property type="gene ID" value="HMPREF0766_13502"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021264_0_3_10"/>
    <dbReference type="OrthoDB" id="1701876at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="27"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="202" mass="23691" checksum="E35F58E39E35FF63" modified="2010-10-05" version="1">MYLVKAPFFLKWYYPDNILWNKSRDEKKLYLTFDDGPIPEITPFILDTLKAFDVRGTFFCVGENIVKNPEIYARILAEGHRVGNHTYNHLKGWDTPDQEYLENISKCQQLTGTDLFRPPYGRPKRSQLKHLKHFQVVMWDILSGDFDLRLTPENCFKNVLKYTKNGSIIVFHDNIKAIPRVTYALPKTLEHFTASGYTFHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRH8</accession>
    <name>D7VRH8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994777.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56379">
        <property type="protein sequence ID" value="EFK56379"/>
        <property type="gene ID" value="HMPREF0766_13582"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095340_0_0_10"/>
    <dbReference type="OrthoDB" id="2120707at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="255" mass="28636" checksum="F1EEE80F835C5FBA" modified="2010-10-05" version="1">MANIQKLIGIGTTLFIVICLGSLYYSLEVFYYSDFGCGCSSNCRAYYPVFTSRFIGYIFIICSAALFIAGIWRIRGLSRVWIIPAMLIFGVASYGNGYMVFNKGSCGLSLNRTIFFINQTKLGDFAKADAESINIDSLNEGKLKGKLLGYALNGRELTAFRIDAEPLKINTGFLFWYVPDSIIINDISYGLSTLRNIEAENVKGHYEFIGGQGMVEKDFLNEFVLTQRELSGILKNKRIINSKDGTTRFLFEMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRI0</accession>
    <name>D7VRI0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994779.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13584"/>
    <dbReference type="EnsemblBacteria" id="EFK56381">
        <property type="protein sequence ID" value="EFK56381"/>
        <property type="gene ID" value="HMPREF0766_13584"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4068">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148614_0_0_10"/>
    <dbReference type="OrthoDB" id="1806295at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="120" mass="14175" checksum="9438D6123C584B5A" modified="2010-10-05" version="1">MKIAERVCIECNSPLKGRSDKRFCDDGCRNNYNNRLNSDQTIYVRTVNTILRKNRKILMEALTEDHKVKVGKTDLNEAGFQFDYFTHQYKTTAGKIYMFVYEYGYLPLNDDQILLVKKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRP8</accession>
    <name>D7VRP8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase, S41 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994919.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13652"/>
    <dbReference type="EnsemblBacteria" id="EFK56449">
        <property type="protein sequence ID" value="EFK56449"/>
        <property type="gene ID" value="HMPREF0766_13652"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031949_1_0_10"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TSPc" evidence="1">
        <location>
            <begin position="163"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="431" mass="47854" checksum="83216EDB02212834" modified="2010-10-05" version="1">MQKIYKSRQPYYNIWSRYLLFLFVPAFFLASCKKDKDPGPEEEEIISPTTGTRTQFTLDSIFLYARHVYLWQDALPTYQDFDPRTRYGSISPELTAFKKELFDITQYKKNSAGIPFENPIGTGVPKYSYIEKGTGRSGSTAAIASTSSPILYQKTWQEGNQSIGYIALGSFPLLSSCQAALDESFAAMAAFAPANLIIDLRSNGGGYVETATYLTNLIATTALNGKVMFTEQFNPIMQNGKATILKHQVYLNEQGKTVSYEGRVATMADVDFSEKENTKIFEKKGKLESVKNIYFIVTGRTASASELVISSLMPYFPVKLIGQKTYGKPVGFFAINIDQYNLYLASFLIRNANGWSDYFNGIPVDVTITGTSALPLGDPNEPYLAATLDLISGKVKSTSARSATTQSTQTEKQEIPYVPMIKSDLKLKPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRT9</accession>
    <name>D7VRT9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chloride transporter, ClC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_13693</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995036.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13693"/>
    <dbReference type="EnsemblBacteria" id="EFK56490">
        <property type="protein sequence ID" value="EFK56490"/>
        <property type="gene ID" value="HMPREF0766_13693"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015263_5_1_10"/>
    <dbReference type="OrthoDB" id="1560952at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="469"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="534"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK56490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="596" mass="66149" checksum="E5B68D1D42A6DBDC" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRX6</accession>
    <name>D7VRX6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995128.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13730"/>
    <dbReference type="EnsemblBacteria" id="EFK56527">
        <property type="protein sequence ID" value="EFK56527"/>
        <property type="gene ID" value="HMPREF0766_13730"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1128490_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036725">
        <property type="entry name" value="ColE3_ribonuclease_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="246" mass="29282" checksum="3491549E0E926390" modified="2010-10-05" version="1">MNVYFHFPEAFDEDKKIINSFIEVLMLTKKHSDFKIYYSESNLNTYKELNADAEIYLTEEIKVIRQFLSSQRAVKMDISNVQTSYIRWHLANYNAYNCEEALISIAEKLYLNSNYNYILLNLQNGIESCRNKILVFRDSMHLNYPDYFVKIDYVINDVEFAEWLKTRSVKEFSLKDENKFQKRPEITVKGATVYYEIKNERYWHLDTFHQFIEYEVYNSDGIHIGTANDKGQISIEGKKKGRTINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRZ5</accession>
    <name>D7VRZ5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13749"/>
    <dbReference type="EnsemblBacteria" id="EFK56546">
        <property type="protein sequence ID" value="EFK56546"/>
        <property type="gene ID" value="HMPREF0766_13749"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3157934_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="48" mass="5859" checksum="EADA193F0A4E1C4D" modified="2010-10-05" version="1">MIILTWYKCQKNKINAQYVGKYAQSLDFTCKYINLLKRWNKIYVNILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS43</accession>
    <name>D7VS43_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56594">
        <property type="protein sequence ID" value="EFK56594"/>
        <property type="gene ID" value="HMPREF0766_13797"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3066346_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="53" mass="5898" checksum="C22788A589B21CC8" modified="2010-10-05" version="1">MGISVTFSLCNQPCSPSSLNKNICKSPLLPSFMLHIRKEKNSSKTKKGYPLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS51</accession>
    <name>D7VS51_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995308.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13805"/>
    <dbReference type="EnsemblBacteria" id="EFK56602">
        <property type="protein sequence ID" value="EFK56602"/>
        <property type="gene ID" value="HMPREF0766_13805"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8UY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_410440_0_0_10"/>
    <dbReference type="OrthoDB" id="469334at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032267">
        <property type="entry name" value="DUF4832"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032379">
        <property type="entry name" value="DUF4874"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045474">
        <property type="entry name" value="GEVED"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16116">
        <property type="entry name" value="DUF4832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16173">
        <property type="entry name" value="DUF4874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20009">
        <property type="entry name" value="GEVED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4874" evidence="2">
        <location>
            <begin position="61"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4832" evidence="1">
        <location>
            <begin position="250"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="GEVED" evidence="3">
        <location>
            <begin position="586"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="669" mass="74931" checksum="0888A4CD1E2C4AA5" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS73</accession>
    <name>D7VS73_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="1">4.1.2.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fbaB</name>
        <name evidence="1" type="ORF">HMPREF0766_13827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13827"/>
    <dbReference type="EnsemblBacteria" id="EFK56624">
        <property type="protein sequence ID" value="EFK56624"/>
        <property type="gene ID" value="HMPREF0766_13827"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1830">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057069_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00958">
        <property type="entry name" value="DhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="369" mass="40292" checksum="31CF5F0B02BF5AF7" modified="2010-10-05" version="1">MYSNSFNIKENIMAIIDQITTYLGNEADELLRYESKAVARDILHLPSPDFIDQVYGISDRNPQTIRSLGQLFGYGRLANTGYLSILPIDQGIEHSAGASFAANPLYFDPENIVKLAIEGGCNAVATTFGVLGSVARRYAHKIPFIVKINHNELLTYPNKSEQILYGTVREAWNLGAAAVGATIYFGSDDSGRQIVEVAKAFEEAHRLGMATILWCYLRNDAFKTGGKDYHLSADLTGQANHLGVTIQADIIKQKLPELNGGYQALNMGSSSYGKLDERMYTELASDHPIDLCRYQVLNCFSGRAGLINSGGASGKNDFPDAVKTAVINKRAGGTGLISGRKAFQRPMKEGVQLLHAIQDVYLSKDITIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSG9</accession>
    <name>D7VSG9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_13923</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995573.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13923"/>
    <dbReference type="EnsemblBacteria" id="EFK56720">
        <property type="protein sequence ID" value="EFK56720"/>
        <property type="gene ID" value="HMPREF0766_13923"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107331" evidence="5">
        <location>
            <begin position="19"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="128"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="528"/>
            <end position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK56720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1112" mass="124267" checksum="4F8CED06BE51C3EA" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSH1</accession>
    <name>D7VSH1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995575.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13925"/>
    <dbReference type="EnsemblBacteria" id="EFK56722">
        <property type="protein sequence ID" value="EFK56722"/>
        <property type="gene ID" value="HMPREF0766_13925"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040532_0_0_10"/>
    <dbReference type="OrthoDB" id="1031920at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="310"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="490" mass="56340" checksum="866EEDF580CB83A3" modified="2010-10-05" version="1">MSSGKKIWNKRSVLLFSGGLITFVVLVFCMLHLMNQRLERLNSTILKEINAESALLVQKEFDVFDQSIFLLRTLAETKEFSSIDRLIQEDSKKKFIAGYQIWKGKDESVRSILHQQLFIPLAADRLQLLSVTPKESETATFIKTQDGMYIARQFMLDDGILQVYIDVKKLNEYFWTSSLGNRSYFEIYNADGICLINPELEKVGVQDNRKVRLDYSKGNVVINSDFIKLPVLIQKYKIHGILGECDLLLSTLFLITDEEVTGIANLSILLGLVLVFAIVVFLTIFYLQRRKNHRLEVNNLHYQKEQALLKFEQLQEKMDPHFLFNSLGTLQQLIGKDGKLAKSFVTKLARVYRKLLSADDSGLSLISTELELAEEYFFLQKIRFGDGLSPLDVQLDLSLRNRKVPRLSLQILLENAIKHNEISAENPLSIRIYQQDQRIVVSNDLRLRLSGDESNGYGTQFLANIYDYYQVSGFEITEDKSSFKVFLPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSK8</accession>
    <name>D7VSK8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="1">1.1.1.42</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Oxalosuccinate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">icd2</name>
        <name evidence="6" type="ORF">HMPREF0766_13962</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the monomeric-type IDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995621.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13962"/>
    <dbReference type="EnsemblBacteria" id="EFK56759">
        <property type="protein sequence ID" value="EFK56759"/>
        <property type="gene ID" value="HMPREF0766_13962"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025308_1_0_10"/>
    <dbReference type="OrthoDB" id="222705at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004436">
        <property type="entry name" value="Isocitrate_DH_NADP_mono"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36999">
        <property type="entry name" value="PTHR36999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03971">
        <property type="entry name" value="IDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009407">
        <property type="entry name" value="IDH_monmr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00178">
        <property type="entry name" value="monomer_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="133"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="83"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="546"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="583"/>
            <end position="584"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="588"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="599"/>
            <end position="601"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="648"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="2">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="2">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK56759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="739" mass="79937" checksum="D2C899F1373439FE" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSP6</accession>
    <name>D7VSP6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L31 type B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmE</name>
        <name evidence="4" type="synonym">rpmE2</name>
        <name evidence="5" type="ORF">HMPREF0766_14000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995694.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14000"/>
    <dbReference type="EnsemblBacteria" id="EFK56797">
        <property type="protein sequence ID" value="EFK56797"/>
        <property type="gene ID" value="HMPREF0766_14000"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114306_2_2_10"/>
    <dbReference type="OrthoDB" id="2014569at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00502">
        <property type="entry name" value="Ribosomal_L31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027493">
        <property type="entry name" value="Ribosomal_L31_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="82" mass="9720" checksum="5187DC7979CF4460" modified="2010-10-05" version="1">MKKDLHPSNYRLVVFKDMSNDYAFITKSCVDTKETIQWEDGNEYPLIKLEISHTSHPFYTGKMKLVDTAGRIDKFRSRYNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSQ9</accession>
    <name>D7VSQ9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995725.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14013"/>
    <dbReference type="EnsemblBacteria" id="EFK56810">
        <property type="protein sequence ID" value="EFK56810"/>
        <property type="gene ID" value="HMPREF0766_14013"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50330EP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139601_2_0_10"/>
    <dbReference type="OrthoDB" id="2053555at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="111" mass="13205" checksum="999B1AAB34FADC27" modified="2010-10-05" version="1">MNNRFRNEKKGKILFMIPFIIGMVFLLVWVVQSLWNALLPEIIGVKAISYWQAFGILVLSKILFGGFRFKGKGKACDRSHLRSKLEQLSPEDKEKFKEEWKQRFSRRWHDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VST8</accession>
    <name>D7VST8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995798.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14042"/>
    <dbReference type="EnsemblBacteria" id="EFK56839">
        <property type="protein sequence ID" value="EFK56839"/>
        <property type="gene ID" value="HMPREF0766_14042"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50312GE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1049328_0_0_10"/>
    <dbReference type="OrthoDB" id="1048724at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024213">
        <property type="entry name" value="DUF3822"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12864">
        <property type="entry name" value="DUF3822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="260" mass="30145" checksum="FBE8326CC8305EEC" modified="2010-10-05" version="1">MNYTSDQFNIQYLPHYTLLVKTGFHTDTILVSDENGTVQVMMEYESEQPEPSALQLLSLPFVRVKIVVPHQSLVFVPNELFKEEALGDYTQFLMDEQQGNTLHQKLNLGGVTAVYQFDAILYNRWKSLFPEAQFIPEFQVILEQAQQHIPLQGEVIGVHFGDQTADIFVFLNGQFQLYNTFEIYSVEDLTYYLLRIFSSFHIKDKVQKLLISGEIPEEDYRQRLAQLAERVETLTAKIKISSSDEQVQQQLQGLNTLFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSU6</accession>
    <name>D7VSU6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid/peptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0766_14050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995817.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14050"/>
    <dbReference type="EnsemblBacteria" id="EFK56847">
        <property type="protein sequence ID" value="EFK56847"/>
        <property type="gene ID" value="HMPREF0766_14050"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004790_0_2_10"/>
    <dbReference type="OrthoDB" id="470322at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17346">
        <property type="entry name" value="MFS_DtpA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005279">
        <property type="entry name" value="Dipep/tripep_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="PTHR11654"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00924">
        <property type="entry name" value="yjdL_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="29"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK56847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="526" mass="58108" checksum="5C3673D4929D13D3" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT46</accession>
    <name>D7VT46_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996029.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14150"/>
    <dbReference type="EnsemblBacteria" id="EFK56947">
        <property type="protein sequence ID" value="EFK56947"/>
        <property type="gene ID" value="HMPREF0766_14150"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50331GG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109344_0_0_10"/>
    <dbReference type="OrthoDB" id="1499934at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021823">
        <property type="entry name" value="DUF3408"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11888">
        <property type="entry name" value="DUF3408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="144" mass="16876" checksum="B72D76EFEA8E8660" modified="2010-10-05" version="1">MEKDNKKKVTPDINEELMMNLMVDGVKKEGLQLPPETADEPEQKVSVREEPTREKPAVKEKSRTKKATEADYESIFFKKSETNARDGKTVYIRPEFHEKLTRIIQVIGEDKISIYAYLDNLLDYHFQEFGEQITKSYNDKYKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT49</accession>
    <name>D7VT49_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14153"/>
    <dbReference type="EnsemblBacteria" id="EFK56950">
        <property type="protein sequence ID" value="EFK56950"/>
        <property type="gene ID" value="HMPREF0766_14153"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50347PT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_193057_0_0_10"/>
    <dbReference type="OrthoDB" id="1997856at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="84" mass="9503" checksum="C5BEE7060AD5D09B" modified="2010-10-05" version="1">MIFINGFMQAYFDKSEKMGNGIEPFFPVTFNPSRRADFCVQQNTASCVLSISKVFSDAEQLALAGGWKTPSEVRVLYRLKMDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTD8</accession>
    <name>D7VTD8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996271.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57039">
        <property type="protein sequence ID" value="EFK57039"/>
        <property type="gene ID" value="HMPREF0766_14242"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1371470_0_0_10"/>
    <dbReference type="OrthoDB" id="1968331at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="199" mass="22864" checksum="B2F2C0B0CA3D7857" modified="2010-10-05" version="1">MFGNQQNDKIRIIKANTGEISTEIKARVDSRNNIIYIYFQHLPVNWYVEDGDYLERDLPGDRIEKFTIKNNGYQPAGKISPERYECIVTKGDTFDREAYSFITYNLHGDNSRVYNNSVDNSSNIISSDNGSEVFILLNKIIDEQLSSNSVLLNLVKDMEQSHKDKSFVSLETYQKFIAQAANHMTLFSPFIPALTEMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTJ2</accession>
    <name>D7VTJ2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996399.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14296"/>
    <dbReference type="EnsemblBacteria" id="EFK57093">
        <property type="protein sequence ID" value="EFK57093"/>
        <property type="gene ID" value="HMPREF0766_14296"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033KGM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2342322_0_0_10"/>
    <dbReference type="OrthoDB" id="2209718at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="95" mass="10931" checksum="99D396C053B84937" modified="2010-10-05" version="1">MIRKILFIFLLAVYALLLLFYVGLVVPEYLACTGCMYEGEKGIDIWGSEIDCSGESRAVGEGFFQLFSIVVSIYSILIIFIIYRIRRSKLNTQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTN0</accession>
    <name>D7VTN0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RND transporter, HAE1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bpeF2</name>
        <name evidence="5" type="ORF">HMPREF0766_14350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001654.1">
        <property type="nucleotide sequence ID" value="NZ_GL379777.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14350"/>
    <dbReference type="EnsemblBacteria" id="EFK55789">
        <property type="protein sequence ID" value="EFK55789"/>
        <property type="gene ID" value="HMPREF0766_14350"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_1_10"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="874"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="896"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="926"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="971"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1004"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK55789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1063" mass="116490" checksum="5615374D01E874AC" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTY3</accession>
    <name>D7VTY3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Penicillin-binding protein, transpeptidase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ftsI</name>
        <name evidence="4" type="ORF">HMPREF0766_14453</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002300.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14453"/>
    <dbReference type="EnsemblBacteria" id="EFK55762">
        <property type="protein sequence ID" value="EFK55762"/>
        <property type="gene ID" value="HMPREF0766_14453"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_6_4_10"/>
    <dbReference type="OrthoDB" id="213680at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="650"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK55762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="708" mass="78218" checksum="BB862E05DE320D23" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGD7</accession>
    <name>D7VGD7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10056"/>
    <dbReference type="EnsemblBacteria" id="EFK60112">
        <property type="protein sequence ID" value="EFK60112"/>
        <property type="gene ID" value="HMPREF0766_10056"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3317201_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK60112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="39" mass="4870" checksum="18952DD8049413A3" modified="2010-10-05" version="1">MNYLCKGEGRQITKQQKESDLFCEKKYFENYFLFSYIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGQ7</accession>
    <name>D7VGQ7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10176"/>
    <dbReference type="EnsemblBacteria" id="EFK59259">
        <property type="protein sequence ID" value="EFK59259"/>
        <property type="gene ID" value="HMPREF0766_10176"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1659621_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="159" mass="17434" checksum="A46A92E885547872" modified="2010-10-05" version="1">MLCPNDNATTVDFHVNLLKSTDKFRFVLIANAAAQLQTALNGLPANAEKETLMSRIEYRVSTRWNAISSANFTPLPMWGESETIDGIDNNTQKFSVNMLRSLAAIDVKVTDNDFIMTKVYVYNMPGKGRIAPVAGNYNAAEYKVTAPSIPAGTNKLTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGT0</accession>
    <name>D7VGT0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">recF</name>
        <name evidence="9" type="ORF">HMPREF0766_10199</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the RecF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996849.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10199"/>
    <dbReference type="EnsemblBacteria" id="EFK59282">
        <property type="protein sequence ID" value="EFK59282"/>
        <property type="gene ID" value="HMPREF0766_10199"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040267_0_1_10"/>
    <dbReference type="OrthoDB" id="891841at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00617">
        <property type="entry name" value="RECF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="22"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="368" mass="42880" checksum="6DAEC210A9FDB783" modified="2010-10-05" version="1">MWLKQLSVLNFKNYTESALEFLPEVNAFAGENGAGKTNLLDAIHYLSLCKSYFNPIDSQHIKQGMDWFMVQGSFENDTRTDVISCSLKKNQKKQFKKNKKDYPRLADHIGQFPLVMISPNDSMIITDGSEERRKFMDNVISQTDHHYLDKLITYNKVILQRNIMLKQARESGQLDLGLLEVLNLQLVEVGAQIFEKRQQFMKDFLPEFEKHYHFLTESAEQVSLVYESPLMTIDFQDLLDRNLERDRALERTSQGIHKDDLLFTIHEGMPLKKFGSQGQQKSFLIALKLAQYSFLQSRKGFKPLLLLDDIFDKLDERRTRKLMQMVSEDDFGQIFLTDTDSERVQRIFEEIAQPIRIFDIKGGAIQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGU7</accession>
    <name>D7VGU7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gidB</name>
        <name evidence="2" type="synonym">rsmG</name>
        <name evidence="3" type="ORF">HMPREF0766_10216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996898.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10216"/>
    <dbReference type="EnsemblBacteria" id="EFK59299">
        <property type="protein sequence ID" value="EFK59299"/>
        <property type="gene ID" value="HMPREF0766_10216"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065341_2_2_10"/>
    <dbReference type="OrthoDB" id="1590629at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003078">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="127"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="211" mass="24169" checksum="D444310983E7F7E8" modified="2010-10-05" version="1">MNPSVDIIYKYFPKLTETQKNQFAQLAELYPFWNNQINVISRKDIESLYLHHVLHSLGIAKFMTEFAPGTHILDVGTGGGFPGIPLAILFPEVKFHLVDSIGKKIKVVREVATALGLTNVEADHMRAEQLDYKYDFVVSRAVTRLGDFTPWIRNKFLKQDKNGVPNGILYLKGGDLKEEIKESRLKAELHPLSDYFTEDFFETKYVVYVPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGY1</accession>
    <name>D7VGY1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Caa(3)-type oxidase, subunit IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_10250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996992.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10250"/>
    <dbReference type="EnsemblBacteria" id="EFK59333">
        <property type="protein sequence ID" value="EFK59333"/>
        <property type="gene ID" value="HMPREF0766_10250"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148689_0_0_10"/>
    <dbReference type="OrthoDB" id="1698209at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005171">
        <property type="entry name" value="Cyt_c_oxidase_su4_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03626">
        <property type="entry name" value="COX4_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="127" mass="14779" checksum="2B251A40A019EA7F" modified="2010-10-05" version="1">MSNHHDNTAAHEGHGHDHEGMDKKGIWRIFFVLLALTCLEFLIALGFVHHWQILAKGALVNTIYIVLTLVKAYYIVAYFMHLKFEKSSFIVCCGVVFIFIVYFIILMLTEGGYLLHHFHEYPLWPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGY3</accession>
    <name>D7VGY3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome c oxidase, subunit III</fullName>
            <ecNumber evidence="9">1.9.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0766_10252</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.9.3.1" evidence="9"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996998.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10252"/>
    <dbReference type="EnsemblBacteria" id="EFK59335">
        <property type="protein sequence ID" value="EFK59335"/>
        <property type="gene ID" value="HMPREF0766_10252"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044071_4_2_10"/>
    <dbReference type="OrthoDB" id="1502742at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="PTHR11403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="8">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="198" mass="22617" checksum="20DACD41E625D6B2" modified="2010-10-05" version="1">MVVDMVNTELQEEELQQSRKAKKFNLWLGMIGMFMMFAALSSGFIVYTASGVDKGIKTTLPNAFIYSTVLILLSSVTLHLSYKAVKEKQFAKQKGLLLATVVLGILFFVCQVHAWQVLIERGIYFLNINASQSFIYVFTGMHLAHIIAGLIVLIRCYTGAAKPIPYDNNLFRMELATIFWHFLDLLWIYIYVFLLLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH06</accession>
    <name>D7VH06_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997066.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10275"/>
    <dbReference type="EnsemblBacteria" id="EFK59358">
        <property type="protein sequence ID" value="EFK59358"/>
        <property type="gene ID" value="HMPREF0766_10275"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025928_1_0_10"/>
    <dbReference type="OrthoDB" id="744729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041662">
        <property type="entry name" value="SusD-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12771">
        <property type="entry name" value="SusD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="586" mass="66857" checksum="130EA9E376A76A23" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH71</accession>
    <name>D7VH71_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_10340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997203.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10340"/>
    <dbReference type="EnsemblBacteria" id="EFK59423">
        <property type="protein sequence ID" value="EFK59423"/>
        <property type="gene ID" value="HMPREF0766_10340"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5375">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098275_2_1_10"/>
    <dbReference type="OrthoDB" id="1736673at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015221">
        <property type="term" value="F:lipopolysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010664">
        <property type="entry name" value="LipoPS_assembly_LptC-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026265">
        <property type="entry name" value="LptC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06835">
        <property type="entry name" value="LptC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04409">
        <property type="entry name" value="LptC_YrbK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK59423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="200" mass="22466" checksum="B400C43963A31F7B" modified="2010-10-05" version="1">MTAFISILKHTLPLSIILWLGAILLHSCEPDLKEVDRIANMKKGEAVDISYGVTITYSDSALVKAVLTSPEMRVHHDTTSNYEFPKGVKIVFYDALGKESQQIVSDYAIQREKEKTTTFKKNVVITRIDGSIIKTEELIYDENSDSFYNHVMITGFFKDGRGNLQGSSFTSDADFKDVRIQNATGLYYIQDNSAFPSFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHG8</accession>
    <name>D7VHG8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rpsK</name>
        <name evidence="9" type="ORF">HMPREF0766_10437</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997450.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10437"/>
    <dbReference type="EnsemblBacteria" id="EFK59520">
        <property type="protein sequence ID" value="EFK59520"/>
        <property type="gene ID" value="HMPREF0766_10437"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0100">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072439_5_0_10"/>
    <dbReference type="OrthoDB" id="1713391at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="129" mass="13876" checksum="14B97A30A5FFA317" modified="2010-10-05" version="1">MAKTKKATKKRIVVIEPVGQAHINATFNNIIVTLTNNQGQTISWSSAGKMGFRGSKKNTPYAASQAASDCGKVAHDLGLRKVEVFVKGPGAGRESAIRTLQTVGIDVTTIKDITPLPHNGCRPPKRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHL8</accession>
    <name>D7VHL8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997548.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10487"/>
    <dbReference type="EnsemblBacteria" id="EFK59570">
        <property type="protein sequence ID" value="EFK59570"/>
        <property type="gene ID" value="HMPREF0766_10487"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125017_0_0_10"/>
    <dbReference type="OrthoDB" id="1454569at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="165" mass="19350" checksum="A70CAFEFDA6A01A2" modified="2010-10-05" version="1">MKAIDKYLSQALDNYPYSLTETIESLEYALSYDETNTTALCLTGRLYAEQLMNYEEAKKYFQEALTCNLYALEIYPHFAQTLIWNDDFEEAQKLIDFALTIKGINKTEILLKQVQLLEKQMKVKKALRLVKGLYVTNCYSSYDQDIKNAEARLEDKLKRDKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHQ8</accession>
    <name>D7VHQ8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ser/Thr phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997642.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10527"/>
    <dbReference type="EnsemblBacteria" id="EFK59610">
        <property type="protein sequence ID" value="EFK59610"/>
        <property type="gene ID" value="HMPREF0766_10527"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051012_0_0_10"/>
    <dbReference type="OrthoDB" id="1242748at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PPA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="PTHR22953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="140"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="387" mass="44325" checksum="783FDF84879D487D" modified="2010-10-05" version="1">MGVASATFALSAYQQAFAQTIQQQDFNFRVRPYLQDLQGDRVTVMTHINRKGFTWLEVRAQGEQQFRKVVQSEDGLINANTLSTVLTIHGLQPGKTYEYRVYAKEILTFEAYKVVYGKEISSPLYTFKTPDANSQTTSCVIYNDVHGRAHSYGQLLDSAGKPEFDFAILNGDMFDYVTNEEDLYDKLLTPLGERFASEKPFFMLRGNHETRGAYSRDFKNFFRYEDNTYYGTFRRGPVSWLMLDTGEDKPDTAEVYAGVVDFDQYRIDQAKWAEKIMASDAFRKSTFRVVVMHIPPFYSGEWHGPMEVQRLFAPLFDKYKVDVVISGHTHTYGFHEATAKHSYPVFIGGGPKEGNRTLIHVKADNRKLEVNMILDNGTNVGTYSKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIC6</accession>
    <name>D7VIC6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998119.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10745"/>
    <dbReference type="EnsemblBacteria" id="EFK59828">
        <property type="protein sequence ID" value="EFK59828"/>
        <property type="gene ID" value="HMPREF0766_10745"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028644_3_0_10"/>
    <dbReference type="OrthoDB" id="1770293at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028348">
        <property type="entry name" value="FAD-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42842">
        <property type="entry name" value="PTHR42842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038984">
        <property type="entry name" value="FAD_binding_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="514" mass="56669" checksum="6150A173E09F2FB0" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIC9</accession>
    <name>D7VIC9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FeS assembly ATPase SufC</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sufC</name>
        <name evidence="6" type="ORF">HMPREF0766_10748</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10748"/>
    <dbReference type="EnsemblBacteria" id="EFK59831">
        <property type="protein sequence ID" value="EFK59831"/>
        <property type="gene ID" value="HMPREF0766_10748"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_48_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK59831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="256" mass="28357" checksum="75DE8C399DAEFA77" modified="2010-10-05" version="1">MIKNMLSIKNLHASVEDKQILKGLNLEVKAGEVHAIMGPNGAGKSTLGNVLAGRESYEVTDGTALLDGVDLLDLSPEDRAREGLFLAFQYPVEIPGVSNINFLKTAVNDIRAYKGLAPMEAKEFLQMVKEKQKLVEFSANLANRSLNEGFSGGEKKRNEIFQLAMLNPKLSILDETDSGLDIDALRVVANGVNQLRSKDNAFVVITHYQRLLDYIVPDFVHVLYNGRIVKSGPKELALELEEKGYDWLKELDTQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIF7</accession>
    <name>D7VIF7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein</fullName>
            <ecNumber evidence="8">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_10776</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the phytochrome family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998180.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10776"/>
    <dbReference type="EnsemblBacteria" id="EFK59859">
        <property type="protein sequence ID" value="EFK59859"/>
        <property type="gene ID" value="HMPREF0766_10776"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_50_1_10"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001294">
        <property type="entry name" value="Phytochrome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01033">
        <property type="entry name" value="PHYTOCHROME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0157">Chromophore</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PHYTOCHROME_2" evidence="6">
        <location>
            <begin position="136"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="517"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="731" mass="84740" checksum="6A0AA6CF32DC1033" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIJ4</accession>
    <name>D7VIJ4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10813"/>
    <dbReference type="EnsemblBacteria" id="EFK59896">
        <property type="protein sequence ID" value="EFK59896"/>
        <property type="gene ID" value="HMPREF0766_10813"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3122809_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="50" mass="5875" checksum="28648EAD6CDE3C90" modified="2010-10-05" version="1">MQILFTEVDDLAVGVFYTVVWLFNRILLNLIPLLFSFLPFDNPCTCPDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIM6</accession>
    <name>D7VIM6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998317.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10845"/>
    <dbReference type="EnsemblBacteria" id="EFK59928">
        <property type="protein sequence ID" value="EFK59928"/>
        <property type="gene ID" value="HMPREF0766_10845"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4833">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_483875_0_0_10"/>
    <dbReference type="OrthoDB" id="1239276at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="SSF49695"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="563" mass="60356" checksum="87C85745D9FBDEC4" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIN7</accession>
    <name>D7VIN7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_10856</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998342.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10856"/>
    <dbReference type="EnsemblBacteria" id="EFK59939">
        <property type="protein sequence ID" value="EFK59939"/>
        <property type="gene ID" value="HMPREF0766_10856"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_10_1_10"/>
    <dbReference type="OrthoDB" id="439303at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="50"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="315"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="798" mass="89337" checksum="25E1F1B1F7AB0291" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIQ1</accession>
    <name>D7VIQ1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="2 7">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">purD</name>
        <name evidence="10" type="ORF">HMPREF0766_10870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="2 7"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998372.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10870"/>
    <dbReference type="EnsemblBacteria" id="EFK59953">
        <property type="protein sequence ID" value="EFK59953"/>
        <property type="gene ID" value="HMPREF0766_10870"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027420_3_1_10"/>
    <dbReference type="OrthoDB" id="932854at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="111"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK59953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="424" mass="45947" checksum="A6B8DDA35DAD6AEA" modified="2010-10-05" version="1">MNILIIGSGGRESAFAYKIAQSKKLDKLFIAPGNAGTLAYGENVPLKVTDFEGQAQFALDNKIDLILVGPEEPLVKGIHDYFLSREDIKHIPVIGPQQEGAQLEGSKDFSKQFMQRHQIPTAASRSFDRSNLEEGLAYLETQNLPIVLKADGLAAGKGVLICESLQEAKDELKAMIADAKFGAASDVVVVEEFLKGIELSVFVLTDGTSYKVLPSAKDYKRIGEGDTGLNTGGMGSISPVPFADEIFLSKVEERIIKPTVDGLKKDNIPYKGFIFIGLMNVGGEPFVIEYNVRMGDPETESVLPRIESDLVDLLEGVAQGNLDTRSYTVSSKTAVTVMLVSGGYPGDYESGKVISNIENVKESIVFHAGTKEQNGEVLSAGGRVIAVTTLQDTLFDALQQATADAGRIYFDGKYFRRDIGFDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIR3</accession>
    <name>D7VIR3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10882"/>
    <dbReference type="EnsemblBacteria" id="EFK59965">
        <property type="protein sequence ID" value="EFK59965"/>
        <property type="gene ID" value="HMPREF0766_10882"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2883621_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="63" mass="7313" checksum="D72F5E052116910C" modified="2010-10-05" version="1">MIAQTVVLQGTYTSCVTRQKSLFLGFENMYLCTSKIRLFCEEIKPYKPRAGTEQKAVTFYIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIS4</accession>
    <name>D7VIS4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998419.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10893"/>
    <dbReference type="EnsemblBacteria" id="EFK59976">
        <property type="protein sequence ID" value="EFK59976"/>
        <property type="gene ID" value="HMPREF0766_10893"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096029_0_0_10"/>
    <dbReference type="OrthoDB" id="1825422at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="254" mass="28452" checksum="AB8C692F8E5F1341" modified="2010-10-05" version="1">MVKFLTGLRHKTTDMKKIILGILILGIMGTTYAQQQVTDNLRKVSTKGKAEKEVTPDIIYLSVSLKEYYLDGNTKKKVTIETLEKQLFDAAMANGIKKEDFTIQNIWSYNNNDPKKKKNSELLQSRQYRLKVTDLSKLNSLFDDVDAKGLQNTSINEYDYSGKKELEKQLKTEAVNDAKSNATILAAAAGDKVGKVLIINDNTSFNFANYAPSVRAMSFKSADAMGGAPEQESLDIDIKPIKIYMEIDAIFELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIT4</accession>
    <name>D7VIT4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998438.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10903"/>
    <dbReference type="EnsemblBacteria" id="EFK59986">
        <property type="protein sequence ID" value="EFK59986"/>
        <property type="gene ID" value="HMPREF0766_10903"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_18_4_10"/>
    <dbReference type="OrthoDB" id="1526822at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="165" mass="19028" checksum="0678B418E3BCA26C" modified="2010-10-05" version="1">MSITIQKATEQEAETIAQIGRASYYTTYPEILSADQIEFMLEKSYTASAISQLMKEGHLFYILYDEGEEQGFLSVRLKPEDSAVLRIEKLYLLAVAQKKGFGRRLISFAEDEGIRFGCKVLELNVNRNNPAYHFYIKEGFHVSEEVDIPYFGYVLDDYVMQRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIV6</accession>
    <name>D7VIV6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PSP1 C-terminal domain protein</fullName>
            <ecNumber evidence="3">3.4.23.36</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yaaT</name>
        <name evidence="3" type="ORF">HMPREF0766_10925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998487.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10925"/>
    <dbReference type="EnsemblBacteria" id="EFK60008">
        <property type="protein sequence ID" value="EFK60008"/>
        <property type="gene ID" value="HMPREF0766_10925"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033149_0_1_10"/>
    <dbReference type="OrthoDB" id="1523756at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="92"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK60008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="432" mass="49558" checksum="4FD2B5FEE5009134" modified="2010-10-05" version="1">MTSGCNKLDVYDWLSNMDMPSNYKAFDIVEVRFKGSRKDFFINTDNHYLEMGEMVVVEPSTGGYDIGHVSLTGELVRLQLKKNNVSVDAVTKKIYRKANEADVKKFEAAKDLEWETMHKARKLALDLGLSMKISDVDYQGDKTKATFYYTAEGRVDFRELIKKMAESFRIRIEMRQIGMRQEASRLGGIGSCGRELCCSTWLTDFKTVSTSAARYQNLSLNTLKLAGQCGKLKCCLNYELDSYMDALKDIPNNVDRIETVIGTAYLQKTDIFKKTMWYAYPKAENWIPLSVDKVKEFIEMNREGRKPEELVNPNIQEEVEKPVVYDYENVVGQDSLTRLDERRKKKSKSKNRNKNKQTVQKADGVAEDKKSVNKHNNKPQQPKVQQAKKEDNTESKSAKEPQNTDAPKPKKRFNNRNRNKGKNNNNGSQPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIX8</accession>
    <name>D7VIX8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase C</fullName>
            <ecNumber evidence="2">3.1.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_10947</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial phospholipase C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.3" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998530.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10947"/>
    <dbReference type="EnsemblBacteria" id="EFK60030">
        <property type="protein sequence ID" value="EFK60030"/>
        <property type="gene ID" value="HMPREF0766_10947"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008770_1_0_10"/>
    <dbReference type="OrthoDB" id="250274at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034480">
        <property type="term" value="F:phosphatidylcholine phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017767">
        <property type="entry name" value="Bact_PC-PLC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008475">
        <property type="entry name" value="PLipase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05506">
        <property type="entry name" value="DUF756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03396">
        <property type="entry name" value="PC_PLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF756" evidence="5">
        <location>
            <begin position="635"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK60030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="836" mass="94769" checksum="66BBBDD4D41087D9" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIY8</accession>
    <name>D7VIY8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="5">4.1.2.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Queuosine biosynthesis protein QueD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">queD</name>
        <name evidence="11" type="ORF">HMPREF0766_10957</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.50" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998549.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10957"/>
    <dbReference type="EnsemblBacteria" id="EFK60040">
        <property type="protein sequence ID" value="EFK60040"/>
        <property type="gene ID" value="HMPREF0766_10957"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111016_2_0_10"/>
    <dbReference type="OrthoDB" id="1770189at2"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070497">
        <property type="term" value="F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK60040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="137" mass="16211" checksum="D47A4F6353B90DFC" modified="2010-10-05" version="1">MIFITRRERFSAAHKLYREDWSSEQNENVFGKCSNPNWHGHNYELFVTVKGEVNPETGFLIDLKKMKEIILHHIIEKLDHRNVNLDVDFMKGKLASTEYMAIEIFNVLNPLFEEHNVILHSVKLVETENNYVEYFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ15</accession>
    <name>D7VJ15_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002103.1">
        <property type="nucleotide sequence ID" value="NZ_GL379779.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10984"/>
    <dbReference type="EnsemblBacteria" id="EFK59150">
        <property type="protein sequence ID" value="EFK59150"/>
        <property type="gene ID" value="HMPREF0766_10984"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5034AS7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1260784_0_0_10"/>
    <dbReference type="OrthoDB" id="1854843at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="220" mass="25712" checksum="A80FCECEC1BD28C5" modified="2010-10-05" version="1">MKILIPILTTLFLLIFCKYDSISMSTLVNIENNRNYDKKQSIEDSVEIYHDSLYFELELNFTEISEEEFHVYKDKYNTSCVIDSSHFIQGSNLYIAQDCKEICETYLCEKNTNRKLRLPSGFDSGISTILLSPSCTQMIICSSYDGPDYSDYYENRAEMFVFNVTNGMGIRGIKPAFKYYSRKWSIEELTWVNEHTIALKVYEANQNTAQYKYLKTELSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJA5</accession>
    <name>D7VJA5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4Fe-4S binding domain protein</fullName>
            <ecNumber evidence="6">1.6.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ndhI</name>
        <name evidence="6" type="ORF">HMPREF0766_11074</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.3" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000506.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11074"/>
    <dbReference type="EnsemblBacteria" id="EFK58958">
        <property type="protein sequence ID" value="EFK58958"/>
        <property type="gene ID" value="HMPREF0766_11074"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067218_4_4_10"/>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="189" mass="21293" checksum="B07412C2ECB8C14A" modified="2010-10-05" version="1">MMLIKTTINALLTAVKGLSLTVRHLFGARRARHELDITKDHYFDKQDGVATVQFPKQKMPIPEVARYQLEVEIDDCIVCDLCAKACPVDCIDILAIKSPEAIGKTSDGSVKRLYAEKFDIDMAKCMYCGLCTVVCPTECITMTNQYDRSTSKLTDLIYGFSDMSDTEVAQRKEEWTKFQAEKEAAKKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJF9</accession>
    <name>D7VJF9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADH-ubiquinone/plastoquinone (Complex I) family protein</fullName>
            <ecNumber evidence="5">1.6.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mrpD</name>
        <name evidence="5" type="ORF">HMPREF0766_11128</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.-.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000622.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11128"/>
    <dbReference type="EnsemblBacteria" id="EFK59012">
        <property type="protein sequence ID" value="EFK59012"/>
        <property type="gene ID" value="HMPREF0766_11128"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_9_2_10"/>
    <dbReference type="OrthoDB" id="1887859at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="4">
        <location>
            <begin position="129"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="500" mass="55117" checksum="9FE17DB51DDEF5CB" modified="2010-10-05" version="1">MIDNYILAPVFIHLFTAIVQLIFWRKTVTQRVLSILGSTLGLSAAIKLFARVYDGPILTMSAGNWDAPFGIVFVADTLSTTLVLLTSIASLAVSIFSATGISRQRIRYGYFPIFHFLILGLNGAFLTGDIFNLYVYFEVIIISSFVLMTLGGRKAQLEGAVKYMAMNILASTFFLTGIGILYGITGSLNMADLALKIPNVKDQTLVGITSSFFIIGFGIKSAVFPLYFWLPSSYHTPPSAVAATFGGLLTKVGIYAMFRIYSLIFIPSPFMKNLLLTLAILTIVTGALGAMTKTNIRRLFSYLIVCHIGFMVGGLAMFSKLALMGAVFYLIHDIMVKTNLFLIAGLIRQLRGSMDMKKIGGLYAEYPKISLLIGIVLFSLVGIPPLSGFWPKIYLIQDAFRLQNYAFIAAIILGSFITLYVIAKMWSEVFWKKPDNEAEVEDKFEPLPLYKKILLVAPIAILAGVSLYIGLNAEDIIKVSDKIATEMLDTRPYIQAVLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJK1</accession>
    <name>D7VJK1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative gliding motility-associated lipoprotein GldB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000698.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11170"/>
    <dbReference type="EnsemblBacteria" id="EFK59054">
        <property type="protein sequence ID" value="EFK59054"/>
        <property type="gene ID" value="HMPREF0766_11170"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5504">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070771_0_0_10"/>
    <dbReference type="OrthoDB" id="932535at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019853">
        <property type="entry name" value="Motility-assoc_lipoprot_GldB"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03514">
        <property type="entry name" value="GldB_lipo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="347" mass="40508" checksum="1EA41EEEFF24D0E2" modified="2010-10-05" version="1">MLKFPHSTQIYLFFFILTFLSCKERAGNDIDTSKIDINIKIERFDQDFSQLDSTRVLWQNAGWQKKYGQFYADYIQLMLHAGNPSDSLSVQRNLRTISRQPDFKALSASVANVFPDLKKQEEGLTEAFKRMKYFFPELHIPRFISFYSGFEVQTPIGEDYIGIGLDMFLGSNSEFYPALVSTIPLYISKRFTPENIVPRVTESFIREELYPQQEGDVNTLQHMIYQGKILYAMDQVMPDVADSLKIGYSAQQMKWAEAYEKEIWAWFIQENLLYNTDYLRIQKYFAEAPFTPELGENNESAPKLGSYIGWQIVRKYMDKHPESDLKKLFAIKDAQLILDESKYKGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJT2</accession>
    <name>D7VJT2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoyl synthase</fullName>
            <ecNumber evidence="6">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lip-syn</fullName>
            <shortName evidence="6">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">lipA</name>
        <name evidence="8" type="ORF">HMPREF0766_11251</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000906.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11251"/>
    <dbReference type="EnsemblBacteria" id="EFK59135">
        <property type="protein sequence ID" value="EFK59135"/>
        <property type="gene ID" value="HMPREF0766_11251"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033144_2_1_10"/>
    <dbReference type="OrthoDB" id="1184806at2"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="57"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="293" mass="33175" checksum="F6C49F0ECEF5F9AA" modified="2010-10-05" version="1">MIELPVIPVTPTQRRPDWLRVKLPVGKEYRHVRSLVDEHKLHTICESGNCPNMGECWGAGTATFMILGNICTRSCSFCAVATGRPLPADLDEPNRVADSVKLMQVKHCVITSVDRDDLKDGGSTIWAETINAIRRESPETTLETLIPDFKGQWDNLDRVLAVRPEVVSHNLETVRRLTREVRIQAKYDRSLECLRRISEAGLRTKSGIMLGLGETEEDVIEAMQDLYDVGVHILTLGQYLQPTKAHHPVIDWITPAQFDKYKEIGLKMGFKYVESGPLVRSSYHAEKHLFDMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJX0</accession>
    <name>D7VJX0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11289"/>
    <dbReference type="EnsemblBacteria" id="EFK58572">
        <property type="protein sequence ID" value="EFK58572"/>
        <property type="gene ID" value="HMPREF0766_11289"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139194_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="161" mass="18230" checksum="523B6898945593C1" modified="2010-10-05" version="1">MWSHNSGYYGAAAGGMVGTHTNHPFSIITNGVSKVTVLSNGYTGIGTTTPTERLSVNGNIRAREIKVETTNWPEYVFEEDYKLKSLKEVETFIKANKHLPDVPSAREIEEDGLSLGEMNKLMMKKIEELTLHLIEKDKTQKLYEQQLADMAERLKKIEEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK54</accession>
    <name>D7VK54_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpsF</name>
        <name evidence="6" type="ORF">HMPREF0766_11373</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998937.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11373"/>
    <dbReference type="EnsemblBacteria" id="EFK58656">
        <property type="protein sequence ID" value="EFK58656"/>
        <property type="gene ID" value="HMPREF0766_11373"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113441_4_3_10"/>
    <dbReference type="OrthoDB" id="1776954at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="122" mass="13913" checksum="6E9347C386FD9547" modified="2010-10-05" version="1">MQQYESVIILTPLLSDDVAKEVIAKFKNILTEGGAEIVAEDNWGLKKLAYPIQKKTTGFYHLTEFKAPGELIKKIEIELRRDERVMRFLTIALDKHAIAYSEKKRSGAFNKKAETKTEEVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKF8</accession>
    <name>D7VKF8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">slyA</name>
        <name evidence="2" type="ORF">HMPREF0766_11477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999220.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11477"/>
    <dbReference type="EnsemblBacteria" id="EFK58760">
        <property type="protein sequence ID" value="EFK58760"/>
        <property type="gene ID" value="HMPREF0766_11477"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_27_2_10"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="156" mass="18011" checksum="0084439457F2FB8C" modified="2010-10-05" version="1">MKIEEELKVRQFKSEWHKVTVNLVFTANKLTEILEKRAEKQQITLQQFNALRILRGQYPNPATNNLLKSRLLTNTPDISRLMDRLVAKDLISRCKSSGDKRSVDLLITDKGLQVLEELEEVMLLNDILPKNFKEKDCEKLSDLLDKLRGSLCSGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKL1</accession>
    <name>D7VKL1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999360.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11530"/>
    <dbReference type="EnsemblBacteria" id="EFK58813">
        <property type="protein sequence ID" value="EFK58813"/>
        <property type="gene ID" value="HMPREF0766_11530"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132888_2_2_10"/>
    <dbReference type="OrthoDB" id="1872172at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PTHR31435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="93" mass="10679" checksum="CBE1020B7E8BA2D8" modified="2010-10-05" version="1">MEIKHVQEGQKGYFSMMDQDIEAGRITYTYAGETKIIIDHTDVNDEYRGQSIGKKIVLEIVDFARTNHIKILPLCPFAKSVFDKSPEIKDVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKM8</accession>
    <name>D7VKM8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex</fullName>
            <ecNumber evidence="5 10">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">sucB</name>
        <name evidence="14" type="ORF">HMPREF0766_11547</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA</text>
            <dbReference type="Rhea" id="RHEA:15213"/>
            <dbReference type="Rhea" id="RHEA-COMP:10581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10582"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="2.3.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="10">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5 10"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999393.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11547"/>
    <dbReference type="EnsemblBacteria" id="EFK58830">
        <property type="protein sequence ID" value="EFK58830"/>
        <property type="gene ID" value="HMPREF0766_11547"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_0_0_10"/>
    <dbReference type="OrthoDB" id="1626282at2"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="12">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="13">
        <location>
            <begin position="121"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="80"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="138"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFK58830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="416" mass="44318" checksum="4D38ADCA2CD65E06" modified="2010-10-05" version="1">MSLEIKVPAVGESITEVTLAQWLKQDGDYVEMDENIAELESDKATFELPAEKAGILKIIAQEGDTLEIGAVVCTIEEGSAPAGGDAAPKAEETKAAAQPAASTSAPAASDDEDQNSYAAGTASPAAAKILREKGIDPAAVKGTGKDGRITKEDAEKAQAGAKPAAAQSTTSAPAATPAPAVAGARNERREKMTSLRKTIAKRLVAVKNETAMLTTFNEVNMQPIMDLRAKYKDTFKEKHGVGLGFMSFFTKAVTTALKEWPAVNARIEENELVYSDFADISIAVSAPKGLVVPIIRNAESLSLHEIEKKIGELAGKARDNKLTIEEMTGGTFTITNGGVFGSMMSTPIINAPQSAILGMHNIIQRPVAENGQVVIRPMMYIALSYDHRIIDGRESVSFLVRVKQLLEDPARLLLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKQ5</accession>
    <name>D7VKQ5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ppx/GppA phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999446.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11574"/>
    <dbReference type="EnsemblBacteria" id="EFK58857">
        <property type="protein sequence ID" value="EFK58857"/>
        <property type="gene ID" value="HMPREF0766_11574"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0248">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025908_1_3_10"/>
    <dbReference type="OrthoDB" id="1862004at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="37"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="294" mass="33016" checksum="76D2C8C41B5F671B" modified="2010-10-05" version="1">MRYAAIDIGSNAVRLLIADIDQTKEEISFIKNTLLRVPLRLGDDAFIQHHISDVKFKDMVSTMTAFKNLMDVYRVTDYMACATSAMRDAGNGKEVVKACKKAGVDIQIIDGSLEAEIIYNSHLEQDMDKDKVYLYIDVGGGSTELSLFANSRLVASRSFNLGTIRILDNQDQPETWDELKDWVKTHTQMYKQVYGIGTGGNINKLSRLANAKEDKPMSYSKLKAIYNHLTSYSLKDRINVLGLKQDRADVIIPAAEIFLTIMKIGHLKTIVAPRVGLVDGIIQTLIRRNLKKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKR1</accession>
    <name>D7VKR1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative TIGR01666 family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999457.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11580"/>
    <dbReference type="EnsemblBacteria" id="EFK58863">
        <property type="protein sequence ID" value="EFK58863"/>
        <property type="gene ID" value="HMPREF0766_11580"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1289">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013315_0_1_10"/>
    <dbReference type="OrthoDB" id="1338660at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032692">
        <property type="entry name" value="YccS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12805">
        <property type="entry name" value="FUSC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="FUSC-like" evidence="2">
        <location>
            <begin position="73"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="732" mass="83693" checksum="0DC24185FA28A716" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKU3</accession>
    <name>D7VKU3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YihY family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rbn</name>
        <name evidence="4" type="ORF">HMPREF0766_11612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999507.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11612"/>
    <dbReference type="EnsemblBacteria" id="EFK58895">
        <property type="protein sequence ID" value="EFK58895"/>
        <property type="gene ID" value="HMPREF0766_11612"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045539_5_1_10"/>
    <dbReference type="OrthoDB" id="1421045at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="336" mass="37314" checksum="E7201634E34748C4" modified="2010-10-05" version="1">MSKIPFQARVKDFGGLMMNVINGFLDDKCMKMSASLAYYTVFSIGPLIIIIIWCIGFFYGTQLDGPTGARDEVFKEFSELFGKDVAVQVQSTIQKISFENRSNIGIIVGIVTLIITSTTIFVDIQDSINTIWKVKAKAKKGWLKLIINRLISFSMVLGLGFLLIASLMINGIIVALTNYFGQYFENISLPMLDWINTGITFTVITALFGFIFSFLPDAKVRFRDILGGAIFTALLFMFGRYAISLYITQSATASAYGAAGSIIVLLGWVYYSSAILYFGAEFTKEIAIRYGKGIRPTSFAVLVKQTELEIDVETGQRKISKSTPEVPMNVSEIEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKV0</accession>
    <name>D7VKV0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999524.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11619"/>
    <dbReference type="EnsemblBacteria" id="EFK58902">
        <property type="protein sequence ID" value="EFK58902"/>
        <property type="gene ID" value="HMPREF0766_11619"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_200390_0_0_10"/>
    <dbReference type="OrthoDB" id="2054725at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="61" mass="7257" checksum="868117BFA2EF20E4" modified="2010-10-05" version="1">MFKQITNLNGDEIYLITSLWIFLVFFVAVALMLFWMKKDHIQYMKELPLDGQDEQNGQTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL54</accession>
    <name>D7VL54_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999778.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11723"/>
    <dbReference type="EnsemblBacteria" id="EFK58327">
        <property type="protein sequence ID" value="EFK58327"/>
        <property type="gene ID" value="HMPREF0766_11723"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077108_0_0_10"/>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="303" mass="34142" checksum="74B8C52AB8C5F248" modified="2010-10-05" version="1">MGKPTLLILAAGMASRYGSLKQIDGFGPHGETIIDYSIYDAIKAGFGKVVFIIREEFLDKMREVFDAKLSGKIEVDYAFQDFDLKKFGIDREIERSKPWGTAHAVLSAKNQINGPFCVINADDFYGTDSFVKMAEFLTTEVTDKQMALMGFRVDNTLSDHGYVSRGVCEVSDSGHMKSVTERTKIYYKDIDGEKKIVFEENGVETELDPNSRVSMNFWGFTPLVFEQAEKMFHTFVEENADDPKSEFFIPSVADALVQTGQTDFKVIPTSSKWFGVTYKEDKEIVQESISKLVADGAYPEKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL74</accession>
    <name>D7VL74_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999838.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11743"/>
    <dbReference type="EnsemblBacteria" id="EFK58347">
        <property type="protein sequence ID" value="EFK58347"/>
        <property type="gene ID" value="HMPREF0766_11743"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073312_0_0_10"/>
    <dbReference type="OrthoDB" id="1171959at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025367">
        <property type="entry name" value="DUF4271"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14093">
        <property type="entry name" value="DUF4271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="311" mass="36049" checksum="6C1578C35A6C8959" modified="2010-10-05" version="1">MSAKQFVILCLIIVMGLLLPHRSVANISIQTDSLYVDTVSSLQKMYPLIVPDPDRGITIPQEIKDKVIVTNGDFIKWLKFAETLKKDRPDAVRSGDARENRPVWIISIIMILVFAVALVRLFFPLDFNVIIEAYFKDRLLQQVSKEDNMATSWSYIFLYIIFSFTLGLFLLMYDAYMSGNGYSLTLNNFLKISLIVGVLFILKILFIRFISFVFELDKLVREYIAVLYLVYFNSMLILMPTVLVLSLLPSAYFTFVISFSIILVFILFIYRYLRTAFHLFGNLRFSLFYLILYLCCLEIAPILILVRTLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLH6</accession>
    <name>D7VLH6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000137.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11846"/>
    <dbReference type="EnsemblBacteria" id="EFK58449">
        <property type="protein sequence ID" value="EFK58449"/>
        <property type="gene ID" value="HMPREF0766_11846"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012729_0_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041700">
        <property type="entry name" value="OMP_b-brl_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14905">
        <property type="entry name" value="OMP_b-brl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMP_b-brl_3" evidence="2">
        <location>
            <begin position="429"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="905"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="913"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="927" mass="104387" checksum="E7D8A2348EA1A995" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLH7</accession>
    <name>D7VLH7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase family protein</fullName>
            <ecNumber evidence="2">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pncA</name>
        <name evidence="2" type="ORF">HMPREF0766_11847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000139.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11847"/>
    <dbReference type="EnsemblBacteria" id="EFK58450">
        <property type="protein sequence ID" value="EFK58450"/>
        <property type="gene ID" value="HMPREF0766_11847"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_13_1_10"/>
    <dbReference type="OrthoDB" id="1442962at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="196" mass="21832" checksum="F116FCE91660942B" modified="2010-10-05" version="1">MKALIIVDVQNDFLPGGSLAVEHGDEIIPLINRLQSDYGLIVATQDWHPVHHKSFAKEHPGKSVFEVIELNGLEQRLWPTHCVQGSSGAAFHEQLDMDRVEAVFRKGIDPEIDSYSGFFDNGRRKNTGLAGYLRDRNIEEVHVCGLAADYCVYFTAKDALSLGFKTAILTDATKAIDPAQFEKLARSFEEDSGRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLJ4</accession>
    <name>D7VLJ4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="7">GPI</shortName>
            <ecNumber evidence="7">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucose isomerase</fullName>
            <shortName evidence="7">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphohexose isomerase</fullName>
            <shortName evidence="7">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pgi</name>
        <name evidence="9" type="ORF">HMPREF0766_11864</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000173.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11864"/>
    <dbReference type="EnsemblBacteria" id="EFK58467">
        <property type="protein sequence ID" value="EFK58467"/>
        <property type="gene ID" value="HMPREF0766_11864"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017947_3_1_10"/>
    <dbReference type="OrthoDB" id="417261at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4 7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK58467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="548" mass="61683" checksum="D130C215AB38BCD4" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLK5</accession>
    <name>D7VLK5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit J</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nuoJ</name>
        <name evidence="2" type="ORF">HMPREF0766_11875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000194.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11875"/>
    <dbReference type="EnsemblBacteria" id="EFK58478">
        <property type="protein sequence ID" value="EFK58478"/>
        <property type="gene ID" value="HMPREF0766_11875"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0839">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085957_4_1_10"/>
    <dbReference type="OrthoDB" id="1683794at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="167" mass="18491" checksum="B0F88B88293EBBC2" modified="2010-10-05" version="1">MTIFYFVAFLSIFFALMTIFTKNPVHSVLYLVITFFTFTVHYILLNAQFLAVVNFIVYMGAIMVLFLFVLMLLNLNKESEPMRSGVVKVMGAVAGMCLLVVVLGSLRIIEIDNGDVVAQPSIGLVKQLGEVLFDKFLLPFEISSILLLTAMVGAVLLAKKDTKKVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLQ1</accession>
    <name>D7VLQ1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0111 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000298.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11921"/>
    <dbReference type="EnsemblBacteria" id="EFK58524">
        <property type="protein sequence ID" value="EFK58524"/>
        <property type="gene ID" value="HMPREF0766_11921"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086031_0_1_10"/>
    <dbReference type="OrthoDB" id="1837604at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="215" mass="24557" checksum="B44FAD6936263535" modified="2010-10-05" version="1">MSLNSIFSYFVPKDKKFFPLFEQAGSNLIEMAKLLKENVNSTNLETRKEITKKIEDLEHKGDSITHQIHLELGKNFITPFDREDIHALASSLDDVADFIHGASNRMELYKVLEPSQPMIEITELILEATEHVAKAIYELRDLKNIRNITDSCVRINSVENKADYIFDKAVAELFEYEKDAITLIKYKEVLSAMEDATDKCEDVANVLESILVKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLS9</accession>
    <name>D7VLS9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000009">
        <property type="protein sequence ID" value="EFK58215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11949"/>
    <dbReference type="EnsemblBacteria" id="EFK58215">
        <property type="protein sequence ID" value="EFK58215"/>
        <property type="gene ID" value="HMPREF0766_11949"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2911">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_419539_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025667">
        <property type="entry name" value="SprB_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13573">
        <property type="entry name" value="SprB"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="11"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="88"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="158"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="235"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="306"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="382"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="655" mass="64338" checksum="495F7B62710E2FA0" modified="2010-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLT7</accession>
    <name>D7VLT7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Secretin and TonB N terminus short domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gspD</name>
        <name evidence="7" type="ORF">HMPREF0766_12191</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the bacterial secretin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12191"/>
    <dbReference type="EnsemblBacteria" id="EFK58199">
        <property type="protein sequence ID" value="EFK58199"/>
        <property type="gene ID" value="HMPREF0766_12191"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_429536_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001775">
        <property type="entry name" value="GspD/PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07660">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00811">
        <property type="entry name" value="BCTERIALGSPD"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="STN" evidence="6">
        <location>
            <begin position="270"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="624" mass="68784" checksum="18D4365AC0CA9343" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM12</accession>
    <name>D7VM12_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Bifunctional NAD(P)H-hydrate repair enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="16">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber evidence="16">4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">NAD(P)H-hydrate epimerase</fullName>
                <ecNumber evidence="16">5.1.99.6</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="14" type="primary">nnrD</name>
        <name evidence="15" type="synonym">nnrE</name>
        <name evidence="18" type="ORF">HMPREF0766_12009</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15 16">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 14 16">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 14 16">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="15 16">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 16">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="16"/>
    <dbReference type="EC" id="5.1.99.6" evidence="16"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001194.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12009"/>
    <dbReference type="EnsemblBacteria" id="EFK58017">
        <property type="protein sequence ID" value="EFK58017"/>
        <property type="gene ID" value="HMPREF0766_12009"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024853_4_1_10"/>
    <dbReference type="OrthoDB" id="1748633at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030677">
        <property type="entry name" value="Nnr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017184">
        <property type="entry name" value="Nnr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12 14 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="7 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="17">
        <location>
            <begin position="16"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="15">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="15">
        <location>
            <begin position="134"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="417"/>
            <end position="421"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR017184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFK58017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="512" mass="55250" checksum="98986AC3C0FCAC98" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM22</accession>
    <name>D7VM22_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter, major facilitator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_12019</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001223.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12019"/>
    <dbReference type="EnsemblBacteria" id="EFK58027">
        <property type="protein sequence ID" value="EFK58027"/>
        <property type="gene ID" value="HMPREF0766_12019"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038152_0_0_10"/>
    <dbReference type="OrthoDB" id="1121832at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="9"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="424" mass="45975" checksum="A856109C58FB0BCA" modified="2010-10-05" version="1">MSTIKSTKLFTASCLALLVTSLSFGIRAGMMNQLGIDFQLNATQLGTITATAFWGFPLAIVVGGFIVDIIGMKRLLVMAFLFHLAGIVLTIFAQGYWTLFFSTLLIGIANGTVEAACNPLVAALYPEDKTTRLNYFHLWFPGGIVIGTLLVTLFVNLGIGWQFQVATMLIPTLIYGYLFLKLEFPVTERVSSGYSNSDMYKAVFSPLFLFMFVCMFMTAITELFTGQWISLLLKNVTDNAILLLTITTGIMVVGRAFAKPIVKKLAPQGVLLFSAVFAALGLYLLSTLSGNSIFFAALIFGIGVCYFWPTMIGFVAENIPKSGALGINLLGGAGMFAVSIYTIFMGNFYDNLIVKHLPEGADIQKYSTAAEGSAEAIAFGSAKNLAGPEVLQVTLILPVVLIFAFLGLVLYMRYLKKQSLTSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM65</accession>
    <name>D7VM65_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Redoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001341.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12062"/>
    <dbReference type="EnsemblBacteria" id="EFK58070">
        <property type="protein sequence ID" value="EFK58070"/>
        <property type="gene ID" value="HMPREF0766_12062"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_586481_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="326"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="466" mass="54253" checksum="EDD86760F3D68D0A" modified="2010-10-05" version="1">MSSICRQVVGPQNVYVEKIDSVRIRYDIKGTPKENIFFVKKHIIDGNDEVLGIIPREFEVKNAELFIKAKSPSLIYILYNDKKYPVYIANNNNSITIDVNDTIPKLYYQGSDKFANQYLLARQKILDEEYLNVRSLYSLSLDSFMNLNEKIEDRIIVLREEYFDEIEDDGFKTFDYADIKSLITIRHILFSDYHNYFTKERVEPLKNISEVKVEDFGYDTSCLLSKTYVDLVGMYLNYNVKNRIDCSKEEFENQQLCYFSAKFNIALSIFTNKEISEFFAIQTMIDALDYGLTDFFKTHLEEMKKQFSQSEYLKIAMWKENALNSIEKGKKAPNIKFVRQDSTSFQLNDLLGKVVYLNVWSLGCSSSVEELSGINYLVNEFSDSSKYNFINIYLDNDSNEQKRYLESSPIKGVNVTLSNINDFSKKYFVNTLPRYIIINKEGMVESPYASRPSSPELKAKLKSLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMH1</accession>
    <name>D7VMH1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001533.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12168"/>
    <dbReference type="EnsemblBacteria" id="EFK58176">
        <property type="protein sequence ID" value="EFK58176"/>
        <property type="gene ID" value="HMPREF0766_12168"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072282_2_0_10"/>
    <dbReference type="OrthoDB" id="1452951at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021737">
        <property type="entry name" value="Phage_phiKZ_Orf197"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11750">
        <property type="entry name" value="DUF3307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="242" mass="27241" checksum="4894F9057F28B385" modified="2010-10-05" version="1">MLYTGLILLIAHILGDFVFQPKKWVEGRAHHIRFIFYHVCVHAALLCLFFVRDLQNWWPAIAVIVLSHLAIDSLKVSLERKMTGSPLLLFSIDQTLHLMVLASVMGCHYGIPESLVASVWSVHALILVVGLLLTAFVSPIVLRVFFSKWNQSDEVNAQRQDSLIDAGWIIGVLERLLIVFFININFLEGIGFLLAAKSIFRFGDLANAKDKKFTEYVLVGTLASFVMAIGTGFLIKWLLQMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMM4</accession>
    <name>D7VMM4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">glyA</name>
        <name evidence="10" type="ORF">HMPREF0766_12244</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992688.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12244"/>
    <dbReference type="EnsemblBacteria" id="EFK57171">
        <property type="protein sequence ID" value="EFK57171"/>
        <property type="gene ID" value="HMPREF0766_12244"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_2_1_10"/>
    <dbReference type="OrthoDB" id="861782at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="2"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="361"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK57171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="423" mass="46324" checksum="6B93C56ED51CCD35" modified="2010-10-05" version="1">MERDQAIFNLINDELKRQEEGIELIASENFVSKQVMEAAGSVLTNKYAEGLPGKRYYGGCEVVDEIETIAIDRAKQLFGAEWVNVQPHSGAQANAAVFLAILKPGDKILGFDLSHGGHLTHGSPANFSGKLYEPVFYGVEKETGLIDYKQLEETARREKPKVIICGASAYSRDWDYARIRSIADEIGALVVADISHPAGLIARGLLNDPLPHCHIVTTTTHKTLRGPRGGMIMVGKDFENPWGIKTPKGEIRTITQLLDLAVFPGTQGGPLEHTIAAKAIAYGEALSDDYMNYIVQVKKNAAALAQFFVERDYNIISGGTDNHLMLVDLRNKDISGKEAEAVLGKAGITTNKNMVPFDTRSPFVTSGVRFGTAAITTRGIKETEIIQIGELIDSAINNHANDAELDKIHSKVREMMAEFPLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMT0</accession>
    <name>D7VMT0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12300"/>
    <dbReference type="EnsemblBacteria" id="EFK57227">
        <property type="protein sequence ID" value="EFK57227"/>
        <property type="gene ID" value="HMPREF0766_12300"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3103964_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="51" mass="6285" checksum="20B4D98AE1E7FCE1" modified="2010-10-05" version="1">MIPDRNQAPNEVQRYTIFYEIQKINKQKKRGNFNSPLFFCLFFLYLHVVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMU8</accession>
    <name>D7VMU8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992812.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12318"/>
    <dbReference type="EnsemblBacteria" id="EFK57245">
        <property type="protein sequence ID" value="EFK57245"/>
        <property type="gene ID" value="HMPREF0766_12318"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031T3U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1219076_0_0_10"/>
    <dbReference type="OrthoDB" id="1398998at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="227" mass="27310" checksum="AC0C8D0AFCBBC3DC" modified="2010-10-05" version="1">MNFLSHFYFERYATQPERVLGGILPDLLKNADKKYMFHPNRFETILLDHPQYKPIYEGWNRHLEVDRIFHNTPFFFDHTHRLRIKIQDSLSGLPVRPSFLAHVALELILDHLLLKHQVINVDRFYEDLEKVHPDTIIKFLKIVGLEDTTKFMSYYERFVNSKYTYEYADITRISHALFNIAKRIWDFEPVAGHHLKLTEELIMYTDKQLTDYKSIYFEIQDRLSLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN38</accession>
    <name>D7VN38_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992944.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12408"/>
    <dbReference type="EnsemblBacteria" id="EFK57335">
        <property type="protein sequence ID" value="EFK57335"/>
        <property type="gene ID" value="HMPREF0766_12408"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1980153_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="126" mass="14189" checksum="A2FD33D2C6DFBEAA" modified="2010-10-05" version="1">MIASTIHIQSYLAAHYPDVAEEIITKLTSIKCNPKLVRKISSLATAEEHWEYQLKTIAAVLVLCSPETIHTKSKVRNGIAVSISNVLGVSRQAVCHKVDRARHYYLNVARVREAVDYIVKEVRGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN73</accession>
    <name>D7VN73_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992987.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12443"/>
    <dbReference type="EnsemblBacteria" id="EFK57370">
        <property type="protein sequence ID" value="EFK57370"/>
        <property type="gene ID" value="HMPREF0766_12443"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1331233_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="206" mass="22949" checksum="D7D957A06FDCBBE3" modified="2010-10-05" version="1">MSSKLLILLAMLTLSGCGLFRKSSKKSEKVSFEVSQKKDSISRESIKTDSIGKNLSIDKGTIVTEIERTTITEKKGGTIKGSIPLERIPKGLEILLKDSAGTKISLMLDSISNQLNVRVDQPGEKTTISEKIHHTENKNKTDQQESRTNNEINKEATVNSQGRKKVSLSQISKESEPDNWSFIFWWIGIGLGVVVVIWGIKKFIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNJ3</accession>
    <name>D7VNJ3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993144.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12563"/>
    <dbReference type="EnsemblBacteria" id="EFK57490">
        <property type="protein sequence ID" value="EFK57490"/>
        <property type="gene ID" value="HMPREF0766_12563"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503338X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2844444_0_0_10"/>
    <dbReference type="OrthoDB" id="2007538at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="65" mass="7607" checksum="3CE2926C23367EB7" modified="2010-10-05" version="1">MKAITIEEAKNLARAKSLEKKHKGESVFIIYCNRTEHFYIDTNGLVRLWEKLHGYYVNGVYATED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNQ1</accession>
    <name>D7VNQ1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RteC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993221.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12621"/>
    <dbReference type="EnsemblBacteria" id="EFK57548">
        <property type="protein sequence ID" value="EFK57548"/>
        <property type="gene ID" value="HMPREF0766_12621"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZAA7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079317_0_0_10"/>
    <dbReference type="OrthoDB" id="694160at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018534">
        <property type="entry name" value="Tet_reg_excision_RteC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09357">
        <property type="entry name" value="RteC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="275" mass="32503" checksum="D084577B64EA409B" modified="2010-10-05" version="1">MSNYYEEIIKKLEDEIKEVSLELDGSIALYEVIIELILSRLSEIKEYTLKNGFDSINEEIHFFKYQKPVIVAKLIYYNAIYKIETKKPNDIKAIRKYINGELRKLKRYFESNLEFYKYYRTGSSFVDEKLFVRGKHDIKLSLDTVYFETDHRFSTSHDYKAAKIIANDLIQVYLEDQLHNIIYKDKSIDLPTLSWTGSKAALTELIYGLHSQAVFNNGNTDIITIVRFFENSFNVDLGDFYHTFLELKARKLNRTKFLDSLRDALIKKMEEQDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNS5</accession>
    <name>D7VNS5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Copper-exporting ATPase</fullName>
            <ecNumber evidence="9">3.6.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">copB</name>
        <name evidence="9" type="ORF">HMPREF0766_12645</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.4" evidence="9"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993264.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12645"/>
    <dbReference type="EnsemblBacteria" id="EFK57572">
        <property type="protein sequence ID" value="EFK57572"/>
        <property type="gene ID" value="HMPREF0766_12645"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_3_10"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045800">
        <property type="entry name" value="HMBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19335">
        <property type="entry name" value="HMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="680"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="HMBD" evidence="8">
        <location>
            <begin position="3"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK57572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="706" mass="75773" checksum="A4B1CC6FD543B879" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNT1</accession>
    <name>D7VNT1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57578">
        <property type="protein sequence ID" value="EFK57578"/>
        <property type="gene ID" value="HMPREF0766_12651"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3173343_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="47" mass="5261" checksum="B28DB234FC00C776" modified="2010-10-05" version="1">MLVVELLYCLMGCSMMQVNPNELYPASPTVFCRNFTVCSLQPSGILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNW3</accession>
    <name>D7VNW3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993325.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12683"/>
    <dbReference type="EnsemblBacteria" id="EFK57610">
        <property type="protein sequence ID" value="EFK57610"/>
        <property type="gene ID" value="HMPREF0766_12683"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZN9T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163167_0_0_10"/>
    <dbReference type="OrthoDB" id="2101932at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="127" mass="14515" checksum="A12F847329124F87" modified="2010-10-05" version="1">MKFKSLSQTKYVWIIIILLSIVAIIFKSSYRQYIYANQINDFGIADASPNFFAGLILVIFYFTQYQKITLQKHAIFTAVGLIGYELIQGTVFKNNYFDYKDIIASILGAFAGYLVCSGFKSFPENEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNW5</accession>
    <name>D7VNW5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993329.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12685"/>
    <dbReference type="EnsemblBacteria" id="EFK57612">
        <property type="protein sequence ID" value="EFK57612"/>
        <property type="gene ID" value="HMPREF0766_12685"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115839_0_0_10"/>
    <dbReference type="OrthoDB" id="1208007at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="203" mass="23806" checksum="EF173CA3650F416F" modified="2010-10-05" version="1">MQEFEFIQKLIKTEHGFKPFEDEARKLCGSHSLDDSKNIALELLNHDYYQIRSVGIFILGFIAAEDKTVLSVLKESARNDESWQVQEIIAKAFDQFCRDNGYEHSLPEIKEWLSEKHPNICRAVTEGLRIWTSRPYFKDHPQEAILLISRHKSSDSEYLRKSVGNSLRDIRKKYPELVEKEISNWDLSDSKTAFTHKYVLKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP40</accession>
    <name>D7VP40_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ATP synthase F0, A subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_12760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993454.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12760"/>
    <dbReference type="EnsemblBacteria" id="EFK57687">
        <property type="protein sequence ID" value="EFK57687"/>
        <property type="gene ID" value="HMPREF0766_12760"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_1_10"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="872"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="898"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="928"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="974"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1005"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1052" mass="114201" checksum="436EEEB09C52BB9F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP68</accession>
    <name>D7VP68_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyanophycinase</fullName>
            <ecNumber evidence="4">3.4.15.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cphB</name>
        <name evidence="9" type="ORF">HMPREF0766_12788</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O = [L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate</text>
            <dbReference type="Rhea" id="RHEA:12845"/>
            <dbReference type="Rhea" id="RHEA-COMP:13728"/>
            <dbReference type="Rhea" id="RHEA-COMP:13734"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:137986"/>
            <dbReference type="ChEBI" id="CHEBI:137991"/>
            <dbReference type="EC" id="3.4.15.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.15.6" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993499.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12788"/>
    <dbReference type="EnsemblBacteria" id="EFK57715">
        <property type="protein sequence ID" value="EFK57715"/>
        <property type="gene ID" value="HMPREF0766_12788"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053928_0_1_10"/>
    <dbReference type="OrthoDB" id="1485646at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011811">
        <property type="entry name" value="Peptidase_S51_cyanophycinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02069">
        <property type="entry name" value="cyanophycinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107190" description="Cyanophycinase" evidence="8">
        <location>
            <begin position="24"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK57715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="284" mass="31035" checksum="D2E907B5F3C408FE" modified="2010-10-05" version="1">MKLKFTKALLIIGLGCLSLSSFAKETKEPKGSLFIIGGGAKDQQLIRSMVDAAALSASDYIMILPMASTVADASVADIREQLQEVTDHKITAINFSKSDASDLRLVDSVRKAKLIYITGGDQNRFMAVVEHSPLFDAIHSAYQQGACIAGTSAGAAIMSDQMITGEQAQDSTYRATFNRLNKDNLVTAKGMGLIRTAIIDQHFIKRSRYNRLFSALAEHPDKVCIGIDESTAILIHNKKAKVVGQFQVVVASNPVKLEVNKEGRIIWDDIRLSIYDNGKTFPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP69</accession>
    <name>D7VP69_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Asparaginase</fullName>
            <ecNumber evidence="5">3.5.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ansB2</name>
        <name evidence="5" type="ORF">HMPREF0766_12789</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993501.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12789"/>
    <dbReference type="MEROPS" id="T02.002"/>
    <dbReference type="EnsemblBacteria" id="EFK57716">
        <property type="protein sequence ID" value="EFK57716"/>
        <property type="gene ID" value="HMPREF0766_12789"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021603_1_0_10"/>
    <dbReference type="OrthoDB" id="890789at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="PTHR10188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107755" evidence="4">
        <location>
            <begin position="22"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="246"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="269"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="217"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="350" mass="37579" checksum="E44B0B92B3E9D8AA" modified="2010-10-05" version="1">MKRTIMILLLIGTTLVAFKNASDPPLRTSNPDKTYVLAIHGGAGTILRSNMTPEMEKAYKDALTLALQKGYEQIKNGKSSLDAVEQAIHVMEDSPLFNAGKGAVFTNDGKNELDASIMNGKTLEAGAVAGVTTIKNPISAARAVMEKSEHVMMVGKGAELFAKQAGIEIVDPSYFWTKMRWDALQKIKKEDSTKVQLDHDQKQSQRLGIVNKDSKFGTVGCVALDKNGNLAAGTSTGGMTNKKFGRVGDSPIIGAGTYANNATVAVSCTGWGEYYIRNVAAYTVSALMEYKQEPVKIASQIVIDNIGKMGGDGGLIALDKSGNLAMPFNTEGMYRGMVTADGQIEIYIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP85</accession>
    <name>D7VP85_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Outer membrane insertion signal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12805"/>
    <dbReference type="EnsemblBacteria" id="EFK57732">
        <property type="protein sequence ID" value="EFK57732"/>
        <property type="gene ID" value="HMPREF0766_12805"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3189161_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="46" mass="5231" checksum="6343591EADACB385" modified="2010-10-05" version="1">MFSNVASFSTSKQDTDGAKAYTEFNTNINVFDNFFNTAQFGLTYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPK5</accession>
    <name>D7VPK5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase/carboxylesterase</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993779.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12925"/>
    <dbReference type="EnsemblBacteria" id="EFK57852">
        <property type="protein sequence ID" value="EFK57852"/>
        <property type="gene ID" value="HMPREF0766_12925"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064094_2_0_10"/>
    <dbReference type="OrthoDB" id="1195966at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107488" evidence="1">
        <location>
            <begin position="23"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DLH" evidence="2">
        <location>
            <begin position="106"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="229" mass="25174" checksum="64E44A03E4FAA4A2" modified="2010-10-05" version="1">MYIKSVVSFLIFLTLFIQTTVAQPSPVKGETAYPFMIQLPKAEILENKPPVLVFLHGRSLSGTNLNRVTRYGVLYAMAKGQEVPAIVIAPQSRGGWDPDKVMEVVDYTIRKYNADSSRIYVAGMSMGGYGTMDVAGKYPDRIAAAVAICGGGTLSYAQNLAKVPLWVQHGNKDHIVPMSESKKIVNAIKKADADADVTLTIIPGGNHGSVERLFHQDDIYDWMFKHVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPK9</accession>
    <name>D7VPK9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5606 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993784.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12929"/>
    <dbReference type="EnsemblBacteria" id="EFK57856">
        <property type="protein sequence ID" value="EFK57856"/>
        <property type="gene ID" value="HMPREF0766_12929"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZPSM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118060_1_0_10"/>
    <dbReference type="OrthoDB" id="1695187at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041218">
        <property type="entry name" value="DUF5606"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18347">
        <property type="entry name" value="DUF5606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5606" evidence="1">
        <location>
            <begin position="3"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="134" mass="14957" checksum="48ED5EC4B0BB7C5C" modified="2010-10-05" version="1">MNLRALVSVTGKPGLFKLIGQNKGGFILETLDKAKIKSVVNLSTTKMATLEDITIYGEEEEIKLLDVFETIKTKGLETPDVKASGDTLRDFFREVAPGHDESRVYTSDIKKIISWYNIIKELPIFDEEAPAPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPR8</accession>
    <name>D7VPR8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protozoan/cyanobacterial globin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993868.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12988"/>
    <dbReference type="EnsemblBacteria" id="EFK57915">
        <property type="protein sequence ID" value="EFK57915"/>
        <property type="gene ID" value="HMPREF0766_12988"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104957_4_0_10"/>
    <dbReference type="OrthoDB" id="1697277at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="130" mass="15215" checksum="643381F214DF9D50" modified="2010-10-05" version="1">MAKQDIRTLEDVKLLVNTFYGRVQQDTLIGPIFNTILDGRWEAHLEKMYGFWQTLLLDQHSYFGSPFPPHATLPVEADHFDAWLNLWTNTVREFFEGEKAEEAILRGEKMATMFLSKITYYRNTNARPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPX7</accession>
    <name>D7VPX7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intimin/invasin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13031"/>
    <dbReference type="EnsemblBacteria" id="EFK55828">
        <property type="protein sequence ID" value="EFK55828"/>
        <property type="gene ID" value="HMPREF0766_13031"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_264413_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026341">
        <property type="entry name" value="Bac_Flav_CTERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003344">
        <property type="entry name" value="Big_1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015217">
        <property type="entry name" value="Invasin_dom_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02369">
        <property type="entry name" value="Big_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01345">
        <property type="entry name" value="DUF11"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09134">
        <property type="entry name" value="Invasin_D3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00634">
        <property type="entry name" value="BID_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04131">
        <property type="entry name" value="Bac_Flav_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51127">
        <property type="entry name" value="BIG1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Big-1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Big-1" evidence="3">
        <location>
            <begin position="79"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Big-1" evidence="3">
        <location>
            <begin position="182"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Big-1" evidence="3">
        <location>
            <begin position="284"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Big-1" evidence="3">
        <location>
            <begin position="387"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Big-1" evidence="3">
        <location>
            <begin position="489"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Big-1" evidence="3">
        <location>
            <begin position="591"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="793"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="923"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="801"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK55828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1266" mass="129116" checksum="33B266970A7A3FA4" modified="2010-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQH9</accession>
    <name>D7VQH9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994301.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13233"/>
    <dbReference type="EnsemblBacteria" id="EFK56030">
        <property type="protein sequence ID" value="EFK56030"/>
        <property type="gene ID" value="HMPREF0766_13233"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127592_0_1_10"/>
    <dbReference type="OrthoDB" id="1864858at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="127" mass="14281" checksum="C6618D3B62055902" modified="2010-10-05" version="1">MSSNPVVYFEIPVLDLQRARIFYESVFGFEFEMDNIDNNEMAIFPFKEEEKGISGALAKGEIYQPSLAGILVYFYTQDITETLNTAVQNGAEILYPVTSNGQWGFVAEFKDSEGNRIGLHQALTHEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQI6</accession>
    <name>D7VQI6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, NAD-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994315.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13240"/>
    <dbReference type="EnsemblBacteria" id="EFK56037">
        <property type="protein sequence ID" value="EFK56037"/>
        <property type="gene ID" value="HMPREF0766_13240"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_3_10"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="137"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="325" mass="36631" checksum="FB41332E1CC5012B" modified="2010-10-05" version="1">MAIQINWGMIGAGDVTEVKSGPAFKKVANSDLIAVMRRNEEKVKDYAERHGVQRWYTDALALIRDKEVNAIYIATPPDSHVAYAIAAMEAGKDVYVEKPMALNSTEAEKLVQAQQLYGRKLVIAHYRRAQPYFRKIKELLNNGAIGTARLASVRYFQKTLTAEQLQQPKMKWRIDPQQSGGGLFHDIAPHQIDLMYYFFGKVAASTGISHNQSKMYQAHDIVSGQILFKNDVVFQGIWAFSVHEERDECEIIGSEGRISFSFFDQRIIRLSNKDGEQEFKFEPLPHVQQPMIEEVVNYFGGGDMNPCSAAEGLAVIQVMDSFTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQM2</accession>
    <name>D7VQM2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Na(+)/H(+) antiporter NhaA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Sodium/proton antiporter NhaA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">nhaA</name>
        <name evidence="8" type="ORF">HMPREF0766_13276</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29251"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994386.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13276"/>
    <dbReference type="EnsemblBacteria" id="EFK56073">
        <property type="protein sequence ID" value="EFK56073"/>
        <property type="gene ID" value="HMPREF0766_13276"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015803_1_0_10"/>
    <dbReference type="OrthoDB" id="1805428at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015081">
        <property type="term" value="F:sodium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006885">
        <property type="term" value="P:regulation of pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01844">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023171">
        <property type="entry name" value="Na/H_antiporter_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004670">
        <property type="entry name" value="NhaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30341">
        <property type="entry name" value="PTHR30341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06965">
        <property type="entry name" value="Na_H_antiport_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00773">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0050">Antiport</keyword>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="7" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK56073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="391" mass="41895" checksum="C6504E6B34782AD2" modified="2010-10-05" version="1">MKLINLNIFKQFLKSSTAGGIILFACVIISLIIANSPLADKLSGILNYHIGYESEAVQLKYSVLLWINDGLMAIFFLLVGLEIKRELVEGELSSPKKAILPILAAIGGALLPAAIYTVINLGEVTQHGWGIPMATDIAFALAVVTMLGKKVPASLKIFLAALAIVDDLLAILVIAVFYSGDLHFTYLMYALGIFIVLLAFNRFGVKSIWAYLIPGIFIWYFIHHSGIHATIAGVLVAMTLPTTPDAQESPLEKLEHALTNPVNFIIIPLFALANTNITIHQEMIAGLTSALGVGIIAGLIVGKTVGILTTCYISTKLKISSLPENANWMHITGTGLLAGIGFTMSIFISILSFDDQLLIDEAKFAVLIGSLVSGLLGYLVLSSASKKTAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQM6</accession>
    <name>D7VQM6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994390.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13280"/>
    <dbReference type="EnsemblBacteria" id="EFK56077">
        <property type="protein sequence ID" value="EFK56077"/>
        <property type="gene ID" value="HMPREF0766_13280"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1119606_0_0_10"/>
    <dbReference type="OrthoDB" id="2066511at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107803" evidence="1">
        <location>
            <begin position="20"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="248" mass="28899" checksum="0ADC8478A6ECFA6B" modified="2010-10-05" version="1">MKILELVLLLSLFSSQVFAQKTQEDLLIESFVDTHTDDKEKFSHQLRSALENHDIKTFKNFERVLDSLNSTLTIKNSEKGDYELFTLANGLDHWSYILKNKVIINQSEMTFDYFYDIHNLPNGEYLLIKRSDDMSFSCSEAFIYNGNIKYDYSDVSANEAYGKKVLSVCSWTNVDESFPGKIDAETGLQTIEGGLKTYEPVKIEFDPKNNLIFYSFYRIKDGRKITRKAKYRNSDFKIKSYDARTFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQP1</accession>
    <name>D7VQP1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994410.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13295"/>
    <dbReference type="EnsemblBacteria" id="EFK56092">
        <property type="protein sequence ID" value="EFK56092"/>
        <property type="gene ID" value="HMPREF0766_13295"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50331TQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1466034_0_0_10"/>
    <dbReference type="OrthoDB" id="1825599at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025348">
        <property type="entry name" value="DUF4252"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14060">
        <property type="entry name" value="DUF4252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107449" evidence="1">
        <location>
            <begin position="19"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="157" mass="17663" checksum="12E9CB5040091DF3" modified="2010-10-05" version="1">MKHLLIIVSLLCFSISQAQLSKLDQIFDQYKEGKGVTSIKIGKPMFSMLNKMKLSDNDLESIRPLLTNINSIKMLIVEGDTPGLQSDVSKAISKLNYEELMMINSEENKIKFLAENTQSETINNLLLSIITDDSTIFMILDGKVKYDDISKLINSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQQ0</accession>
    <name>D7VQQ0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MepB protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994419.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13304"/>
    <dbReference type="EnsemblBacteria" id="EFK56101">
        <property type="protein sequence ID" value="EFK56101"/>
        <property type="gene ID" value="HMPREF0766_13304"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111604_0_0_10"/>
    <dbReference type="OrthoDB" id="1726781at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011235">
        <property type="entry name" value="MepB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038231">
        <property type="entry name" value="MepB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08877">
        <property type="entry name" value="MepB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="178" mass="21014" checksum="1FA85B59236891A8" modified="2010-10-05" version="1">MYFSKIKKHYLLMPVATHTNLIIRLIERLYLPVSQLQQLQFDKESSSYHAASFIAEDQNILFRKANITPKKIGQFVTLWKRNSSSGETQPFDTTDQVDRVIILVTDKDRYGVFIFSAEILRKMKIFTHENITGKRGFRVYAPWDNPENKRAMKTKEWQISYFEYLEPDRIESKSILLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQQ4</accession>
    <name>D7VQQ4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fkpB</name>
        <name evidence="6" type="ORF">HMPREF0766_13308</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994429.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13308"/>
    <dbReference type="EnsemblBacteria" id="EFK56105">
        <property type="protein sequence ID" value="EFK56105"/>
        <property type="gene ID" value="HMPREF0766_13308"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0545">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013615_7_3_10"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000774">
        <property type="entry name" value="PPIase_FKBP_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01346">
        <property type="entry name" value="FKBP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="57"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK56105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="143" mass="16031" checksum="E5F25CC848E022A1" modified="2010-10-05" version="1">MASTKYLKKIKDLAERNLKDGIAFLAENAKRDTVIVTSSGVQYEILKEGSGEIPTAKAKVLCHYKGTLLDGTVFDSSYKRRKPEAFLVRELIRGWQEVLVMMPVGSHWKIYIPSHLAYGFESLTESSGGNCTLIFEMELKAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQU3</accession>
    <name>D7VQU3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994476.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13347"/>
    <dbReference type="EnsemblBacteria" id="EFK56144">
        <property type="protein sequence ID" value="EFK56144"/>
        <property type="gene ID" value="HMPREF0766_13347"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZB53">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069557_0_0_10"/>
    <dbReference type="OrthoDB" id="1333443at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107247" evidence="1">
        <location>
            <begin position="27"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="290" mass="32289" checksum="BCAA16D5CD4A9C3B" modified="2010-10-05" version="1">MNTSIIKQYVAAAALLLTVILTNSCSKNNVPEPDADKMGQFSIEFDNIVGEETLGFEPRSYTNAKGEKFRIKQLQYFISNIKLYKNDGSSYTVPQEESYFLVNASDRTTRFTRVQAPEGDYSKVQFVLGIDSLRSTMPVEKRTGVLSFNPESGHAGGGMYWGWNSGYIFLKLEGYCDLISDNQQGDPTGNKQFKYHIGGFGGYNAPTLNNIKTITVDLKSAGIAQVRAGMRSNAHLFVDIMKIFNGPNAFSIVAHPNVMFSEYSVNIANNFPAMFSHDHTENFVKSEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQW7</accession>
    <name>D7VQW7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannitol dehydrogenase domain protein</fullName>
            <ecNumber evidence="3">1.1.1.57</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">uxuB</name>
        <name evidence="3" type="ORF">HMPREF0766_13371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.57" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994508.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13371"/>
    <dbReference type="EnsemblBacteria" id="EFK56168">
        <property type="protein sequence ID" value="EFK56168"/>
        <property type="gene ID" value="HMPREF0766_13371"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027324_0_1_10"/>
    <dbReference type="OrthoDB" id="1442117at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008866">
        <property type="term" value="F:fructuronate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000669">
        <property type="entry name" value="Mannitol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023027">
        <property type="entry name" value="Mannitol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00084">
        <property type="entry name" value="MTLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00974">
        <property type="entry name" value="MANNITOL_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol_dh" evidence="1">
        <location>
            <begin position="16"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol_dh_C" evidence="2">
        <location>
            <begin position="209"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="488" mass="55385" checksum="9D5FED52D9A47E5A" modified="2010-10-05" version="1">MKVHTYNYDRNTIQSGILHIGVGNFHRAHQAFYTDQLLHDEDQKQWGICGACLLPGDEKLVQNLRSQQLDYTLTVCGREGEHDIYRIGSLSELLWAVEDQQELLHKIADSAIRIITLTITEGGYNLDKVTNEFMLDNEWIKDDLIHPANPTTVFGYIAEGLRQRKASGSGGITILSCDNLQHNGNTAKRAFCTFIAAQDPELAEWMETNVSFPNSMVDRITPATTAQDITRLNNQSGIYDKAPVYCEDFIQWVIEDNFIAGRPAWERVGVEFTDDVTAYENMKLSLLNASHTLLSYPSFLIGYRKVDEAMQDKEMVKFVCDFMDTDITPHVPPPTGIDLKEYKQTLIERFANPAVSDQISRLCFDGISKFPVYIMPNLLKMIKDNQELSRVAFLIASYRHYLKYQTDDKQQQFEIAEPWLTAEDRESTKSNNPVDFLRLSAFRSTDLTAVASFVGLYTGFAHSIREKGLKKVLQCIKCAKGGLQSILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR58</accession>
    <name>D7VR58_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tox-HNH-HHH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13462"/>
    <dbReference type="EnsemblBacteria" id="EFK56259">
        <property type="protein sequence ID" value="EFK56259"/>
        <property type="gene ID" value="HMPREF0766_13462"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503186B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1531592_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028915">
        <property type="entry name" value="Tox-HNH-HHH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15637">
        <property type="entry name" value="Tox-HNH-HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tox-HNH-HHH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="175" mass="20391" checksum="BEBE1FB4574B1FB4" modified="2010-10-05" version="1">MNDKWIQYNKTAKAYKGEKLVHHHHSQGRFAYAIPNKVHLKWNRVLHVFRNGGKLSGLKNRMNTLASGVMVLQGLVDIFTGNPDSWITWFQGADKTGVLYYHPINKFYFEMYRIEKIKDASGNVVRAIVEYDAYAGSVWDEDERRYMGVLKVGTFWEEIDVINKRTIGHQELKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRA3</accession>
    <name>D7VRA3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994689.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13507"/>
    <dbReference type="EnsemblBacteria" id="EFK56304">
        <property type="protein sequence ID" value="EFK56304"/>
        <property type="gene ID" value="HMPREF0766_13507"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_17_2_10"/>
    <dbReference type="OrthoDB" id="2051456at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="147" mass="16909" checksum="511F5320E8E0E46A" modified="2010-10-05" version="1">MAKVHHYLNFDGQAENAFNFYKSVFGGEFRSFMRYQDMPSPEKIPDEIGNRILHVVLPISKHFVLMGADVHDDYGSAINRGNNSFILLAADSSEEALRLYKGLSEGGEVEMPMEETYWSQLYSSFKDKYGICWMINYDGSKLDRWGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRB0</accession>
    <name>D7VRB0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994696.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13514"/>
    <dbReference type="EnsemblBacteria" id="EFK56311">
        <property type="protein sequence ID" value="EFK56311"/>
        <property type="gene ID" value="HMPREF0766_13514"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054358_0_0_10"/>
    <dbReference type="OrthoDB" id="1019249at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032713">
        <property type="entry name" value="EmrE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13536">
        <property type="entry name" value="EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="307" mass="33592" checksum="6D1793E4AEDC8146" modified="2010-10-05" version="1">MPDKIRISPIFLGVISSLFFAATFVLNRAMSLDGGHWIWSAALRFVWMLPLLMIIVGFRNGLKPTFAAIKANCWPWILWSTVGFGIFYSTLTFGAKYGPSWLVASTFETTIIFGMLLAPLLSPRAANQISKGSLAFSALIILGIVIMQISQAKFTNWADIAMGTIPVLIAAIAYPLGNRKMMMITDGKLDAYQRTLGMTICSMPFWIILCAFAYHQDGLPSSGQLTQTFIVALSSGVIATVLFFTATDRVRNSPHKLAAVEATQSMEVIFALIGELLILHGAFPDMYSLAGIVLVITGMILHSRHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRK8</accession>
    <name>D7VRK8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1016_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13612"/>
    <dbReference type="EnsemblBacteria" id="EFK56409">
        <property type="protein sequence ID" value="EFK56409"/>
        <property type="gene ID" value="HMPREF0766_13612"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046640_5_2_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041527">
        <property type="entry name" value="YhcG_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17761">
        <property type="entry name" value="DUF1016_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1016_N" evidence="1">
        <location>
            <begin position="10"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="98" mass="11406" checksum="5B26376CCFDCABAA" modified="2010-10-05" version="1">MIINQAIISDIKAIISQSKDVTIRAIDHQRTLMYWHIGKRIFKEEQEGKDRADYGTFLIKYLSDQLQPELEVGFQSGKLICIVNFIGHFQLCIHCMHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRQ3</accession>
    <name>D7VRQ3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994936.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13657"/>
    <dbReference type="EnsemblBacteria" id="EFK56454">
        <property type="protein sequence ID" value="EFK56454"/>
        <property type="gene ID" value="HMPREF0766_13657"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZBNC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092723_0_0_10"/>
    <dbReference type="OrthoDB" id="1482662at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12105">
        <property type="entry name" value="HmuY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025921">
        <property type="entry name" value="HmuY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="237" mass="26325" checksum="B2A4390DAF110D1D" modified="2010-10-05" version="1">MTIQKTVLLPILVGFIFIGCSKSDTPQPDPEPEPPTAESMFNTLITVKNFGEALPQGSEPTTKQSPIYFSLESKQGINPDYKQTARWDLSFDDIYRSFLNCNTPLTGGSGKGGILIVKQKFDDVTDVPADNLFRTGEKSYGTDDSGAFGEGLGWYLYDFGGTIKGGSDPRKAHVCYPIEGHTIIVRTAKGNYAKVRIQSIYKDLLDPKDWYKDSPTPYFTFQYVLVKAGSKTFEIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRR8</accession>
    <name>D7VRR8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tat pathway signal sequence domain protein</fullName>
            <ecNumber evidence="3">3.2.1.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nagA</name>
        <name evidence="3" type="ORF">HMPREF0766_13672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.49" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994975.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13672"/>
    <dbReference type="EnsemblBacteria" id="EFK56469">
        <property type="protein sequence ID" value="EFK56469"/>
        <property type="gene ID" value="HMPREF0766_13672"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046965_0_0_10"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008456">
        <property type="term" value="F:alpha-N-acetylgalactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107306" evidence="1">
        <location>
            <begin position="29"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="60"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="468" mass="52519" checksum="D87B4A2174852C61" modified="2010-10-05" version="1">MNSNRRDFIKLAGLSSLSVLSSSLLVQANTSIPETSEINKLAGLKTFNMCGFKAPKLEKVRVGFIGVGNRGSGAIYRMNHIDGVEIKAISDIRRNIAERSLKNVSGPVPDIYADKEDEWKKLCDRKDIDLVYICTPWHLHTPMAVYAMKAGKHVAIEVPAATTVEECWQLVETSEATKKHCMMLENCCYDFFELMTLNMARQGVFGEILHGEGAYIHDLLDSNFDKNSYYDMWRLKENFRNGNLYPTHGLGPVCQIMDINRGDQMDYLTSVSTNDFSMSARAKELAAKDDFYKQFANKQFRGNMNTTTVRTHKGRTIMLQHDVSSPRPYSRIHAISGTKGYAQKWPEPGKIAFGHDWISADEMKKLEQQYTPEIVLKVGEMAKKVGGHGGMDFMMDWRLIDCLRNGLALDQDVYDAALWSVIGPLSEKSVKNRSNSVDIPDFTKGAWKTNQPVELTLKGGGTTGVKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRZ6</accession>
    <name>D7VRZ6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995176.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13750"/>
    <dbReference type="EnsemblBacteria" id="EFK56547">
        <property type="protein sequence ID" value="EFK56547"/>
        <property type="gene ID" value="HMPREF0766_13750"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032Y59">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_185997_0_0_10"/>
    <dbReference type="OrthoDB" id="1970636at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="81" mass="9421" checksum="45721250F19CD318" modified="2010-10-05" version="1">MRVLAELPHPDCKISIFGMNQKFIIKFEQGVLEQSYKLAETDVVGGVNGVFELLDETFIQQVLSHFQEMRKSFIDSYDRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS06</accession>
    <name>D7VS06_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995200.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13760"/>
    <dbReference type="EnsemblBacteria" id="EFK56557">
        <property type="protein sequence ID" value="EFK56557"/>
        <property type="gene ID" value="HMPREF0766_13760"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1804957_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="143" mass="16812" checksum="3B6863A4DBE33B5A" modified="2010-10-05" version="1">MKYIYILLLLCISGCLSDHSTKKARVIYRIGFDYIELSFDESGYAQAKTGRGNSIDEDSFFAESTTDSVKFYIKNSSIFFKKLEELKEKKIERAKSYTRTQIYLNDSLYFDTEMYSSDFWDIYSNISNEIPDAFNPFKTDRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS34</accession>
    <name>D7VS34_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56585">
        <property type="protein sequence ID" value="EFK56585"/>
        <property type="gene ID" value="HMPREF0766_13788"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_31_8_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="69" mass="7445" checksum="44785C56DE4F1012" modified="2010-10-05" version="1">MSQRKVSLSELSNMVGITLSNLSIIKNGKCRAIRLHTLSAICKALDCQPGDILEYTEQPVSARGKAIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS85</accession>
    <name>D7VS85_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995406.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13839"/>
    <dbReference type="EnsemblBacteria" id="EFK56636">
        <property type="protein sequence ID" value="EFK56636"/>
        <property type="gene ID" value="HMPREF0766_13839"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031879_0_0_10"/>
    <dbReference type="OrthoDB" id="324607at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035423">
        <property type="entry name" value="M60-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042279">
        <property type="entry name" value="Pep_M60_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031161">
        <property type="entry name" value="Peptidase_M60_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17291">
        <property type="entry name" value="M60-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13402">
        <property type="entry name" value="Peptidase_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01276">
        <property type="entry name" value="M60-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51723">
        <property type="entry name" value="PEPTIDASE_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107617" description="Peptidase M60 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M60" evidence="2">
        <location>
            <begin position="103"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="529" mass="60173" checksum="C394850DD486AD40" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSA4</accession>
    <name>D7VSA4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ornithine--oxo-acid aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rocD</name>
        <name evidence="7" type="ORF">HMPREF0766_13858</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13858"/>
    <dbReference type="EnsemblBacteria" id="EFK56655">
        <property type="protein sequence ID" value="EFK56655"/>
        <property type="gene ID" value="HMPREF0766_13858"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4992">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_3_10"/>
    <dbReference type="OrthoDB" id="572533at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050155">
        <property type="term" value="F:ornithine(lysine) transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine-oxo-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="PTHR11986:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="426" mass="47246" checksum="605EC4AB705BF098" modified="2010-10-05" version="1">MNNNIEDMNIQTDKTKSDAFIAKENQYGAHNYHPLPVVLERGEGVFVWDVEGKKYVDFLSAYSAVNQGHCHPRIIHALTEQARKLTLTSRAFFNNKLGEFEEYICKLFGYNKALIMNSGVEAVETAMKLCRKWGYQVKGIPDNQAKIVFAKDNFHGRTISVISASNDEVSTREFGPFVEGIMQVPYNDIQAFENLLKENKNIAGFIVEPIQGEAGIIIPDETYLSEIRRLCTAYNVLFIADEIQTGIGRTGNLLASYDVFASAHNSKPDILILGKALSGGVLPVSAVLADDDIMLTIKPGEHGSTYGGNPLACAVSIEALQVILDEKLTENSRKMGEILRSGLRDIAARMTLIREVRGKGLLTAIEMNCSEEDELAWNLCLEFKKNGLLAKPTHGNKIRLAPPLVINEQQINDCLHIIEKSLNAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSE6</accession>
    <name>D7VSE6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56697">
        <property type="protein sequence ID" value="EFK56697"/>
        <property type="gene ID" value="HMPREF0766_13900"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3157939_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="48" mass="5676" checksum="66B2513017BAFFD9" modified="2010-10-05" version="1">MFYHITLQILDRSQRATIDYFKMKSIEIQPIEQVRSTGKKGISKCNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSG7</accession>
    <name>D7VSG7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13921</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995571.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13921"/>
    <dbReference type="EnsemblBacteria" id="EFK56718">
        <property type="protein sequence ID" value="EFK56718"/>
        <property type="gene ID" value="HMPREF0766_13921"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_14_1_10"/>
    <dbReference type="OrthoDB" id="1958442at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="132"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="241" mass="28157" checksum="681B0C1CE90D9A0F" modified="2010-10-05" version="1">MAIRVLIVEDESWASESLLEMLTELWNDDYTAVVKSTVRDVISWLGKNETDLIFMDIHLGDGLSFDIFNHIKIQTPVIFTTAFDEYALEAFRNRGYAYLLKPFELPELKEALSKVESLLPREELVPQYKNRFLVRYGIRLKSVPVEDIAYFMADDKLLYGFSVQGDRFIVDDTLSKLAPRLDPAFFFQINRKFIIHIQSIAEMVKMSRNRIKLQLHPQVLDNPEIIVSEEKSNDFQLWLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSK4</accession>
    <name>D7VSK4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fabG</name>
        <name evidence="4" type="ORF">HMPREF0766_13958</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995617.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13958"/>
    <dbReference type="EnsemblBacteria" id="EFK56755">
        <property type="protein sequence ID" value="EFK56755"/>
        <property type="gene ID" value="HMPREF0766_13958"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_10"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011284">
        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01830">
        <property type="entry name" value="3oxo_ACP_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="156"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="247" mass="26242" checksum="2E36E2981B7CFA81" modified="2010-10-05" version="1">MKLLEGKTALVTGASKGIGRKIAEVFAQNGANVAFTYLSSVEKGQALEQELQAFGTQVKGYRSDASKFEEAEKLINDIVADFGTVDIVVNNAGITKDGLLMRMTEENWDDVINVNLKSIFNVTKAASKVMMKNRKGSFINMSSVVGVQGNAGQANYAASKAGIIGFSKSVAKELGSRNIRANVVAPGFIRTEMTDVLDPKVVAGWEAGIPLKRSGDPEEVANVCLFLASDLSAYVTGQVIPVDGGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSP5</accession>
    <name>D7VSP5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glmU</name>
        <name evidence="1" type="ORF">HMPREF0766_13999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995693.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13999"/>
    <dbReference type="EnsemblBacteria" id="EFK56796">
        <property type="protein sequence ID" value="EFK56796"/>
        <property type="gene ID" value="HMPREF0766_13999"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055419_0_0_10"/>
    <dbReference type="OrthoDB" id="687997at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023917">
        <property type="entry name" value="Bifunctiontional_GlmU_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13562">
        <property type="entry name" value="NTP_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03991">
        <property type="entry name" value="alt_bact_glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="402" mass="45079" checksum="D6B364D473C29C64" modified="2010-10-05" version="1">MAVDIILFDRASWRDHLLPLVYTRPVGDLHIGILSLAEKWGKIFNCKSSYYTEPYLAVRFPTLITTAEVIVLKANICPSDALIAAIDQLSEGEILYDKTEWIAFRIRSADIDNILTNGYFDSLRPVNLLYDISYIRYPEDIFRYNSAQLQFDYALMTQGRSSESLSGTNQLIGDRIFIEDGVFAECCSFNTTEGPVYLAKGAEISEGSHLRGNVAIGEHARVKMGTRIYGNVSIGANSTVGGELSTLVMGAYSAKGHDGYLGCAVIGNGCNLGAGTSNSNLKNNWKPVSIYDYALDSSRNTDLRKCGLIMGDYTMSGINTSFNTGTVVGVGVQYARPGYSPKFIPDFSWCTDQHTEEYRWDKFEEMLRDMKVMKAEPYHDDETELLRHVYKLTQHNRLKYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSP7</accession>
    <name>D7VSP7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995698.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14001"/>
    <dbReference type="EnsemblBacteria" id="EFK56798">
        <property type="protein sequence ID" value="EFK56798"/>
        <property type="gene ID" value="HMPREF0766_14001"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155065_1_0_10"/>
    <dbReference type="OrthoDB" id="1879070at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021274">
        <property type="entry name" value="DUF2853"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023154">
        <property type="entry name" value="Jann4075-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11015">
        <property type="entry name" value="DUF2853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158587">
        <property type="entry name" value="SSF158587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="112" mass="12375" checksum="A520E8CCC306D83F" modified="2010-10-05" version="1">MSKLDEKVAAYVAEAKKLNLGLDESLIHAVAKGLGPSIYKADAETVAASDKEELARLKNNFLIKKLGLKDSPELDAAISEVIEKLGKSNKNKYRVHVYALLAKKFKKESLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSX8</accession>
    <name>D7VSX8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14082"/>
    <dbReference type="EnsemblBacteria" id="EFK56879">
        <property type="protein sequence ID" value="EFK56879"/>
        <property type="gene ID" value="HMPREF0766_14082"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134269_1_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="64"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="137" mass="15794" checksum="F77D3A75E1A02392" modified="2010-10-05" version="1">MDIKDSCILIQYLYLPLYINLRNFTMEQHSPNFQFDNHTEWEDLGQGVRRKVFGYNDQLMLVKVRFDKGATGTLHRHPHVQTSFVSEGSFKYSIDGEEKILNKGDACLVPSNALHGCECLESGELIDSFAPYREDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT94</accession>
    <name>D7VT94_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fasciclin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14198"/>
    <dbReference type="EnsemblBacteria" id="EFK56995">
        <property type="protein sequence ID" value="EFK56995"/>
        <property type="gene ID" value="HMPREF0766_14198"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_560083_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="49"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="487" mass="53787" checksum="06DCD8DBCD1E0D39" modified="2010-10-05" version="1">MNFISNHMKKIKHIITHSLLGMSILVLLFSCEIQESFDYENAPDNSKLNMSALAYIKGNESLSMFAEAVERTQFASFYEGTTPATFIVPNNQAFTAYLKENGYASIAAIPLPILKNILRYHIVKSVVNFNDPALAPSNRPIAYTTENGQIMYLSHTSTYVGLINEGTNRQWQIRTSNLVPDNGVIHVVNFVVFYSAPTGDANAVNPNLLQDTIFPKHDSYVNGGIESTKNFGTNTLLKIKNVSNNGDYDRKAFLMFDFADFKKQGVVTDLKLQLAVSFTAAKGVDLNLFETPSTSWVEASLNFTNAVFPTSPRIASIKTSKVSTFKFDLTDYYKERKPTGLKSFMLDGQPGSDETDEIASKEHPTLAKPMLIATLATGDSELVLQKQQDFEVSNGGMYVLSNDNLKVDGASAADIIYTIDDLPAFGWFIKGAEVLKKGSRFSQLDLDLRNIVFIHNGETLGTKSLLLTARDKAGAVLEDIKINIIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTA2</accession>
    <name>D7VTA2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="7">3.5.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nagA</name>
        <name evidence="7" type="ORF">HMPREF0766_14206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996171.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14206"/>
    <dbReference type="EnsemblBacteria" id="EFK57003">
        <property type="protein sequence ID" value="EFK57003"/>
        <property type="gene ID" value="HMPREF0766_14206"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032482_2_1_10"/>
    <dbReference type="OrthoDB" id="1026967at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047419">
        <property type="term" value="F:N-acetylgalactosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="PTHR11113:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="54"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="399" mass="43500" checksum="80BBFE550A19197C" modified="2010-10-05" version="1">MTKLLLHNCILVLPASLLENGYVYVEDNRIAGIGQGTPEMQDDTVKTIDLKGRYVAPGFIDMHVHGGGGYDFMDATIEAFLGVSETHVRYGTTAMCPTTLTADRENLYAVLDTYAAALPQNKRGAAWLGLHLEGPYLAMNQRGAQDPKYIRNPDVKEYSSILDYSPHITRWSAAPELSGALAFGDYLQSRGVIPSLAHTDALFEEVVVGYEHGYRLATHFYSAMSTIVRKNAKRYAGVIEAGYYLDGMDVEIIADGIHVPAPLLKLIYKIKGPTRIALVTDAMRAAAMPEGPSVLGRVKDGLPVLVEGGVAKLPDRSAFAGSVATCNQLVRNYRDLAGIPLQEVVSMLTGVPARILGVQDRKGSLETGKDADLVVFDQDIEVYMTIVEGEIRYDRLTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTB1</accession>
    <name>D7VTB1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996196.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14215"/>
    <dbReference type="EnsemblBacteria" id="EFK57012">
        <property type="protein sequence ID" value="EFK57012"/>
        <property type="gene ID" value="HMPREF0766_14215"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014263_0_0_10"/>
    <dbReference type="OrthoDB" id="859922at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021352">
        <property type="entry name" value="DUF2971"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11185">
        <property type="entry name" value="DUF2971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="647" mass="75510" checksum="0E19EC29783C24F2" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTM0</accession>
    <name>D7VTM0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arsenical-resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">arsB</name>
        <name evidence="5" type="ORF">HMPREF0766_14340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001628.1">
        <property type="nucleotide sequence ID" value="NZ_GL379777.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14340"/>
    <dbReference type="EnsemblBacteria" id="EFK55779">
        <property type="protein sequence ID" value="EFK55779"/>
        <property type="gene ID" value="HMPREF0766_14340"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0798">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022869_0_0_10"/>
    <dbReference type="OrthoDB" id="1493959at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015103">
        <property type="term" value="F:inorganic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="PTHR43057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK55779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="343" mass="38628" checksum="4204B799A1F16D0A" modified="2010-10-05" version="1">MQPKLKFLDRYLTLWIFLAMLIGISLGYLFPGISKITNTLSVGTTNIPLAIGLILMMYPPLAKVDYSLLPMVFRDKKVISISLLLNWIIGPILMFILAIVFLRNEPDYMIGLILIGLARCIAMVIVWNDLAKGNREYAALLVALNSIFQVFTYSFMVWLFINVLPARLGLANFDVSISIIDVTESVLIYLGIPFLGGFLSRHFLVKSKGIEWYNRKFIPKISPLTLYALLFTIVLMFSLKSDKILELPMDVIKVAIPLIVYFALMFFVSFFINKSFNVPYDKNTSIAFTATGNNFELAIAVAIAVFGIHSPQAFVGVIGPLVEVPVLILLIKASLWLKSKYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VG88</accession>
    <name>D7VG88_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001826.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10007"/>
    <dbReference type="EnsemblBacteria" id="EFK60063">
        <property type="protein sequence ID" value="EFK60063"/>
        <property type="gene ID" value="HMPREF0766_10007"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZQ43">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1538427_0_0_10"/>
    <dbReference type="OrthoDB" id="1907110at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK60063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="174" mass="19999" checksum="16787E163EECA7A2" modified="2010-10-05" version="1">MTIEELFKEKEIKSKEKTETISNWILEKSLAVEELLVFVENQRDPVKATCIEALEYATRHHPELADEHVLLFVTQSLRSKVPRIKWESAKVIGNIAHLFSTKLKESISNLLDNTTHEGTVVRWSAAFALGQIIRLKTEYNVTLLPAVEEVCEQEQKKSIQKIYQEALNKIKTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGA1</accession>
    <name>D7VGA1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, group 2 family protein</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001862.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10020"/>
    <dbReference type="EnsemblBacteria" id="EFK60076">
        <property type="protein sequence ID" value="EFK60076"/>
        <property type="gene ID" value="HMPREF0766_10020"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_19_1_10"/>
    <dbReference type="OrthoDB" id="1445278at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK60076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="332" mass="37925" checksum="057D97C11DE094B9" modified="2010-10-05" version="1">MFFSIIIPLYNRPQEIDELLDSLLRQRYKHFEVIIVEDGSQKDAKTIVERYQDKLDVHYYFKPNEGQGFARNYGFERAKGDYFIIFDSDVIVPSDYLHEVIIGLQRDHFDAFGGPDAAHESFTPVQKAISYSMTSPFTTGGIRGNKKHIGQFNPRSFNMGISREVWVRTGGFKLARRSEDIEFSIRMIEQGFKVGLIPEAYVYHKRRTSFSQFFKQTNLFGKGRIDIYKLFPKELKPVHALPALFVVGLVILVLLNLLNVVVAGKSGLILFLTSIGNWGLGLYTLLLFFHALYTTRSLQVAFLSVIAAFTQLIAYGSGFIESYIREVILVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGF0</accession>
    <name>D7VGF0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Antioxidant, AhpC/TSA family</fullName>
            <ecNumber evidence="4">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ccmG4</name>
        <name evidence="4" type="ORF">HMPREF0766_10069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.15" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001993.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10069"/>
    <dbReference type="EnsemblBacteria" id="EFK60125">
        <property type="protein sequence ID" value="EFK60125"/>
        <property type="gene ID" value="HMPREF0766_10069"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_1_0_10"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025380">
        <property type="entry name" value="DUF4369"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14289">
        <property type="entry name" value="DUF4369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="236"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK60125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="379" mass="43508" checksum="7955A0B24CE5F32C" modified="2010-10-05" version="1">MKKLLKLLISFLFIVGYTSVYGQTAFTITGYGEKLREGDSLFLSYKENGKFIQKSTTALHHKFTFTGSVKYPTKAYISRNQNPAYAYFITESIHVFLEPGEIEINSPDTLTGAVVSGTALNETLQQFENQQTQLKQKKRLIKDPDQFNESEKKDTALVNYNKRELEKLYYEEADNKLAFARMHPDSYVSLDMLYDLSRINTYIFKVEEVYNTLADNLKQSEYAAIIRERIKTKKKLIPGMKAFDFSMKDVSDNTVSLSEFNGKYVLLDFWASWCGPCREEHPNLIRAYEHYQKYNFTILSVSIDTDKQKWTEAIIKDKLLWPQVSDLKGNNSDVYQKYGITSIPANFLIAPDGTVIAKDLKGDSLTDELIKVLSGVNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGI4</accession>
    <name>D7VGI4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trxA</name>
        <name evidence="6" type="ORF">HMPREF0766_10103</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002061.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10103"/>
    <dbReference type="EnsemblBacteria" id="EFK60159">
        <property type="protein sequence ID" value="EFK60159"/>
        <property type="gene ID" value="HMPREF0766_10103"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_4_10"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="23"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK60159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="100" mass="11371" checksum="62E7534DEBA3D1FA" modified="2010-10-05" version="1">MATFNEILQKHKLALIDFSATWCGPCQQLAPILEDVKKHYGEDLSIIKIDVDKNQALASNFKVQGVPTLILFKDGEQVWRQSGLLMKNNLVQVIDQYRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGI9</accession>
    <name>D7VGI9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10108"/>
    <dbReference type="EnsemblBacteria" id="EFK59191">
        <property type="protein sequence ID" value="EFK59191"/>
        <property type="gene ID" value="HMPREF0766_10108"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2791859_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="68" mass="7764" checksum="7495D2BE7963C893" modified="2010-10-05" version="1">MPRSEILSSPQVCVLCISTIIFILQKYLFPRRITNPGPDIKSKFRKKCRIAVLAAGLLFVCKMSYVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGQ0</accession>
    <name>D7VGQ0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK59252">
        <property type="protein sequence ID" value="EFK59252"/>
        <property type="gene ID" value="HMPREF0766_10169"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3317199_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="39" mass="4550" checksum="1CD31ECD23706000" modified="2010-10-05" version="1">MLGHKNVAATILRYLKRKLKRILEKVSQIFKDMEGSFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGQ2</accession>
    <name>D7VGQ2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BACON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996787.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10171"/>
    <dbReference type="EnsemblBacteria" id="EFK59254">
        <property type="protein sequence ID" value="EFK59254"/>
        <property type="gene ID" value="HMPREF0766_10171"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_444730_0_0_10"/>
    <dbReference type="OrthoDB" id="1406204at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14948">
        <property type="entry name" value="BACON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024361">
        <property type="entry name" value="BACON"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13004">
        <property type="entry name" value="BACON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BACON" evidence="1">
        <location>
            <begin position="387"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="596" mass="65407" checksum="B343F82F3604DAE6" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGQ3</accession>
    <name>D7VGQ3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0766_10172</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Fimbrium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacteroidetes fimbrillin superfamily. FimA/Mfa1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10172"/>
    <dbReference type="EnsemblBacteria" id="EFK59255">
        <property type="protein sequence ID" value="EFK59255"/>
        <property type="gene ID" value="HMPREF0766_10172"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9ID">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_648504_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009289">
        <property type="term" value="C:pilus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029140">
        <property type="entry name" value="FimA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029141">
        <property type="entry name" value="FimA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15495">
        <property type="entry name" value="Fimbrillin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06321">
        <property type="entry name" value="P_gingi_FimA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0281">Fimbrium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106883" evidence="6">
        <location>
            <begin position="27"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="P_gingi_FimA" evidence="7">
        <location>
            <begin position="49"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Fimbrillin_C" evidence="8">
        <location>
            <begin position="370"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="472" mass="50612" checksum="11C45D793E1D949D" modified="2010-10-05" version="1">MNNNLTTKRMSMKKYALIALAGLTLAACKKQGGEINPVNPEEGKDASLSLSITSAANIGTYASTTGSDGGTANESKVNTVDVFLYSEEGSLTPAGYERFSGTDANLSTPKKIKTKTGRKRIYIGINLPQSLVDLLKAGYSGMENPYPVNMEQLATPNDGVMMFSQSVTSLDIKEGDDPANKVTIPVSRLLAKAGVLKGNSLSLTDIQGGTVSDLQYTVGQRNKQILVGQLYDFKDANWAYINPFVSGTSGALTAEYQANFTGVLNTAYKAVDASNTENKDLKTVYMPENTTELPAPTQVTYIQVRAKFTPTKLEDGATPNADGTFYVMFGQKGTNDALHQLYFTTKSAADAEAAKTDYNNGTVQRSVVLTYNQGYCYFRLYLNEDQVAGATKLGILRNTFFKAQITKINGLGTPLEGQIPGTPGTPGNPGGNVKPPKPVDPTQPVNPGNLDANIQATITITPWTLITSEHEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH14</accession>
    <name>D7VH14_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase family 3 N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">xloA</name>
        <name evidence="4" type="ORF">HMPREF0766_10283</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997084.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10283"/>
    <dbReference type="EnsemblBacteria" id="EFK59366">
        <property type="protein sequence ID" value="EFK59366"/>
        <property type="gene ID" value="HMPREF0766_10283"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_5_1_10"/>
    <dbReference type="OrthoDB" id="419160at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107460" evidence="2">
        <location>
            <begin position="22"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="3">
        <location>
            <begin position="491"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="887" mass="98684" checksum="07FEBC54C911BE8E" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHB1</accession>
    <name>D7VHB1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4 11">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">hemB</name>
        <name evidence="13" type="ORF">HMPREF0766_10380</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4 11"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997290.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10380"/>
    <dbReference type="EnsemblBacteria" id="EFK59463">
        <property type="protein sequence ID" value="EFK59463"/>
        <property type="gene ID" value="HMPREF0766_10380"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035731_0_0_10"/>
    <dbReference type="OrthoDB" id="677575at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFK59463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="324" mass="36085" checksum="0DC2FD5A3C35285E" modified="2010-10-05" version="1">MLQRPRRNRKSAVIRDMIQETRLDASNLIFPLFIIDGNQQKTEVSSMPGIYRYSIDNLLREVESCLKLGLKSFDLFPNIEESLKDKYATESYRDGSLYLRAIAEVKKNFPEACVVTDVAMDPYSSDGHDGIVENGEILNDETLDVLGKMALAHAQAGADIIAPSDMMDGRIGYIREHLDQHGFSHVSLMSYTAKYASAFYGPFRDALGSAPKHGDKKTYQMNPANSKEALIEGQLDAAEGADFLMVKPGLPYLDIIKLLADNFDLPIAAYNVSGEYAMLKAAIQNGWLDAERSIMETLLSFRRAGATAILTYHAKEVLEKGWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHC8</accession>
    <name>D7VHC8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase, S8/S53 family</fullName>
            <ecNumber evidence="6">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_10397</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997330.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10397"/>
    <dbReference type="EnsemblBacteria" id="EFK59480">
        <property type="protein sequence ID" value="EFK59480"/>
        <property type="gene ID" value="HMPREF0766_10397"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022359_0_0_10"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107113" evidence="4">
        <location>
            <begin position="22"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="267"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK59480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="544" mass="60257" checksum="687C7C7FEC963BBB" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHD2</accession>
    <name>D7VHD2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997343.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10401"/>
    <dbReference type="EnsemblBacteria" id="EFK59484">
        <property type="protein sequence ID" value="EFK59484"/>
        <property type="gene ID" value="HMPREF0766_10401"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060500_4_2_10"/>
    <dbReference type="OrthoDB" id="1387978at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="258" mass="29043" checksum="A34056629FCE3FE7" modified="2010-10-05" version="1">MKNKYSLILLLILFTLCSPVFGQQPLKILSYNIHHGNPPSKPGVIDLEAIAKVIRTSGADVVGLQEIDVNVGRSENVDQAKKLAELAGMEYYFFSKGIDLEKGEYGTVILSKFPITNTERLELPMPVKSEMRSLGIAKIKIPSGKEILFANTHLDLKEENRIAQTKFIVNHFQDTKHLVVLVGDLNAQPQSEPIKILGNFFKRSEITNGFTIPEVNPTREIDFIMVNKSKNPKFQNHKVIEESYASDHRPVYAEVLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHG5</accession>
    <name>D7VHG5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rplQ</name>
        <name evidence="7" type="ORF">HMPREF0766_10434</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997440.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10434"/>
    <dbReference type="EnsemblBacteria" id="EFK59517">
        <property type="protein sequence ID" value="EFK59517"/>
        <property type="gene ID" value="HMPREF0766_10434"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3743">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074407_0_1_10"/>
    <dbReference type="OrthoDB" id="1838961at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="249" mass="27318" checksum="65B0862C5AE5F301" modified="2010-10-05" version="1">MRHGKKVNHLGRTDSHRKALLANMATSLIKHKRITTTLAKAKALRTYVEPLITKSKDDTTHSRRTVFSYLKDKDAVTILFREISEKVANRPGGYTRIIKMENRLGDNAEMAFIELVDYNEVYGATAATEKKTTRRRGGKKKTEAAEGATEEKATAKKAAKTEVKADDLTIVEGIGPKIAEILVGAGIDTFAKLASTEVSKIEELLAEAGSNYNTAVPTTWPEQAQLAADGKFEELEKLKAELDGGKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHI9</accession>
    <name>D7VHI9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rplB</name>
        <name evidence="7" type="ORF">HMPREF0766_10458</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997497.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10458"/>
    <dbReference type="EnsemblBacteria" id="EFK59541">
        <property type="protein sequence ID" value="EFK59541"/>
        <property type="gene ID" value="HMPREF0766_10458"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_2_1_10"/>
    <dbReference type="OrthoDB" id="961486at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="6">
        <location>
            <begin position="124"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="274" mass="29865" checksum="9BFADC6A7836FF86" modified="2010-10-05" version="1">MAVKRFKPVTPGTRFRVGADYSDVTTNVPEKSLVVKIKKSGGRNNSGKMTMRYLGGGHKKAYRLIDFKRDKKDIPATVATIEYDPNRTARIALLHYADGEKRYIIAPAGLTVGQTVVAGESVAPEIGNTLPLAKIPLGSIIHNIELNPGQGGSIARSAGTYAQLSARDGKYAIIKLPSGETRMILLTCVATIGSVSNQEKFNQVLGKAGRKRWLGRRPRVRGVAMNPVDHPMGGGEGRTSGGHPRSRNGVLAKGFKTRYKKKTSNRYIIERRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHJ9</accession>
    <name>D7VHJ9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Response regulator receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_10468</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997508.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10468"/>
    <dbReference type="EnsemblBacteria" id="EFK59551">
        <property type="protein sequence ID" value="EFK59551"/>
        <property type="gene ID" value="HMPREF0766_10468"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_28_1_10"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="768"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="811"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="1070"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="1216"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="1118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1321" mass="151137" checksum="ECE40276F75CB30D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHM3</accession>
    <name>D7VHM3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Salicylate biosynthesis protein PchB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pchB</name>
        <name evidence="2" type="ORF">HMPREF0766_10492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997559.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10492"/>
    <dbReference type="EnsemblBacteria" id="EFK59575">
        <property type="protein sequence ID" value="EFK59575"/>
        <property type="gene ID" value="HMPREF0766_10492"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131518_2_1_10"/>
    <dbReference type="OrthoDB" id="1980002at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="104" mass="12092" checksum="553DFE5CDD0A2E9F" modified="2010-10-05" version="1">MIRPLEYCENLAHVRSSIDTIDYRILELIALRKDYVAKAADFKNSTEEVIAEERVNQMLKDRLELAKGFGLKASFVEGIFSDIVNYFINEELNKFDEQQSISNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHN8</accession>
    <name>D7VHN8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997584.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10507"/>
    <dbReference type="EnsemblBacteria" id="EFK59590">
        <property type="protein sequence ID" value="EFK59590"/>
        <property type="gene ID" value="HMPREF0766_10507"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003361_0_0_10"/>
    <dbReference type="OrthoDB" id="2346at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020958">
        <property type="entry name" value="DUF3686"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12458">
        <property type="entry name" value="DUF3686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1612" mass="185534" checksum="39F6284E17996380" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHV6</accession>
    <name>D7VHV6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997770.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10575"/>
    <dbReference type="EnsemblBacteria" id="EFK59658">
        <property type="protein sequence ID" value="EFK59658"/>
        <property type="gene ID" value="HMPREF0766_10575"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_106_4_10"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="434"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="637" mass="74335" checksum="FFD62AAEBC9BE446" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI83</accession>
    <name>D7VI83_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide sugar dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">wbpO</name>
        <name evidence="5" type="ORF">HMPREF0766_10702</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998035.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10702"/>
    <dbReference type="EnsemblBacteria" id="EFK59785">
        <property type="protein sequence ID" value="EFK59785"/>
        <property type="gene ID" value="HMPREF0766_10702"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_3_1_10"/>
    <dbReference type="OrthoDB" id="295459at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="324"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="432" mass="47903" checksum="FD77C9F28A170523" modified="2010-10-05" version="1">MKKIAVIGLGYVGLPLARLFATKYPVVGFDINQKRITELMSGKDVTLEVEDNILQDVLQDKNPYSSNTNGLYCSNNLSDIEEANFYVITVPTPVDKHNRPDLTPLYKSSETVGKVLKKGDIVVYESTVYPGVTEEECIPVLERISGLKFNVDFYAGYSPERINPGDKEHTVEKILKVTSGSTPEIGVDVDNVYKSVITAGTHLAPTIKVAEAAKVIENSQRDINIAFVNELAKIFNILDIDTHAVLKAAGTKWNFLPFKPGLVGGHCIGVDPYYLAQKAQEHGYHPEIILAGRRLNDSMGEYVASQVVKLMIKKGINVNGAEILMLGITFKENCPDVRNTKIVDVIKALEEYSMKVTILDPWAKPEDVMKEYGLKTVNDINYTDITKNSFKAVVVGVAHKEFFEMDLSQFLEQGNGIIYDVKGVFKNCDGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI95</accession>
    <name>D7VI95_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidyltransferase-related domain protein</fullName>
            <ecNumber evidence="2">2.7.7.39</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.39" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998060.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10714"/>
    <dbReference type="EnsemblBacteria" id="EFK59797">
        <property type="protein sequence ID" value="EFK59797"/>
        <property type="gene ID" value="HMPREF0766_10714"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0615">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034585_2_3_10"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047348">
        <property type="term" value="F:glycerol-3-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="150" mass="17531" checksum="7BC01F32F659CE4C" modified="2010-10-05" version="1">MKDIQHKDVRIGITFSAFDLLHAGHIKMLEDAKRQCDFLICGLQTDPTIDRPEKNKPTQTVVERYIQLKGCKYVDQIVPYATEQDLEDILRAFKIDVRIVGDEYRERDFTGRQYCEENGIELYFNSRDHRFSSSGLRRIVAEKEAQNTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VID8</accession>
    <name>D7VID8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10757"/>
    <dbReference type="EnsemblBacteria" id="EFK59840">
        <property type="protein sequence ID" value="EFK59840"/>
        <property type="gene ID" value="HMPREF0766_10757"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3296711_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="40" mass="5036" checksum="5A0AAF389D19E907" modified="2010-10-05" version="1">MSPFQIDLIFNFFSFFCYNCNMLKWHKTTIKAFYHNENFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIQ8</accession>
    <name>D7VIQ8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998385.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10877"/>
    <dbReference type="EnsemblBacteria" id="EFK59960">
        <property type="protein sequence ID" value="EFK59960"/>
        <property type="gene ID" value="HMPREF0766_10877"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_586308_0_0_10"/>
    <dbReference type="OrthoDB" id="624309at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="436" mass="49717" checksum="92F0593CC5B4B6EC" modified="2010-10-05" version="1">MAREIIETKRKALQINLNPDIYGTFAEIGGGQEVARNFFGAGAASGTIAKTISAYDMAFSDAIYGAEESGRYVSRPRLNKMLHHEFELLTERLHGEKYATKKFFSFANTVTTLNFTKTNEPHGWIGIRFQTVTNGPINQIIIHTRLLDNDNQQQQKVLGTIGVNLVYAAYYYTNDIQSMIESFVDNVSAGSVEIDLVKVEGPVFERVNERLINLYLVAKGFSKAAIFKPDGKAAQSKDYLYKKDIIILRTKYRQKSLPNFDLFNLAVEQFKRNTNANPENVVVMIEVLMGNVLDEDSNISNEDLKYFAERAEYLCSTGNNILVSNFRRNNHLAEYVTQFKPGNIGIASNISNLRNIFNSDQYNKDHYTNELLGYISGMFSKNVKLYVYPYMDKNENIITTQNLKVSPEAKPLFDFLIQNRYIIDIENYDPKFVKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIX9</accession>
    <name>D7VIX9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAAX amino terminal protease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998532.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10948"/>
    <dbReference type="EnsemblBacteria" id="EFK60031">
        <property type="protein sequence ID" value="EFK60031"/>
        <property type="gene ID" value="HMPREF0766_10948"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067776_1_0_10"/>
    <dbReference type="OrthoDB" id="1623593at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="316" mass="36054" checksum="BC30D4C827030B74" modified="2010-10-05" version="1">MLFTKPINTPVVSMLLLIIISLACSLTLQGIVMFIFAVYSGSFDVLKSGASIMSNPVFSNLLLAVSSISTFGLPAYFLLQAEQRQINYFPVQRRGRLTYLVLVLLTMIAFIPLMSQIAEWNAKMVLPDSLKGIESWMREQEDSAASMMSGIVMKTSWWGLIINLIILAVLPGICEELFFRGVIQTSFFRLFKNQHLAIWVTAIIFSAIHVQFYGFFPRMLLGAFFGYLLIWSNNIWVPIFGHFINNATATIFGFYYSREGKTFEEMNTAETYPWYIYIGSIAATMVLLFILYNYSRKVNDGKRLDKDQDVYKCDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIY6</accession>
    <name>D7VIY6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="3 6">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pdhB</name>
        <name evidence="8" type="ORF">HMPREF0766_10955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="3 6"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998545.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10955"/>
    <dbReference type="EnsemblBacteria" id="EFK60038">
        <property type="protein sequence ID" value="EFK60038"/>
        <property type="gene ID" value="HMPREF0766_10955"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012907_1_1_10"/>
    <dbReference type="OrthoDB" id="900125at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="PTHR11624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transket_pyr" evidence="7">
        <location>
            <begin position="4"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK60038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="328" mass="35929" checksum="B929ADA113094EAF" modified="2010-10-05" version="1">MREIQFREALREALSEEMRKDEKIFLMGEEVAEYNGAYKVSQGMLDEFGPKRVIDTPIAELGFAGIGVGAAMNGLKPIVEFMTFNFSLVAIDQVINAAAKIHSMSGGQFSIPIVFRGPTGNAGQLGAQHSQNFENWYANTPGLKVVVPSNPYDAKGLLKSAIIDPDPVIFMESEVMYGDKGPVPEEEYYLEIGKANVVKEGTDVTVVSFGKMIPRVVLPAIEELTKEGVNVELIDLRSVRPIDYATIVESVKKTNRLVIVEEAWPLASISSEITYKVQRDAFDYLDAPVTRVTAADVPLPYAPTLVEAALPSVAKVVKAVKEVAYLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIZ1</accession>
    <name>D7VIZ1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998555.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10960"/>
    <dbReference type="EnsemblBacteria" id="EFK60043">
        <property type="protein sequence ID" value="EFK60043"/>
        <property type="gene ID" value="HMPREF0766_10960"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013771_1_2_10"/>
    <dbReference type="OrthoDB" id="1375034at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002901">
        <property type="entry name" value="MGlyc_endo_b_GlcNAc-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01832">
        <property type="entry name" value="Glucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00047">
        <property type="entry name" value="LYZ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107005" evidence="1">
        <location>
            <begin position="25"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="LYZ2" evidence="2">
        <location>
            <begin position="22"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK60043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="189" mass="21418" checksum="1862184087AC5758" modified="2010-10-05" version="1">MQEKNFKKVLLVLFLCFLSITTFAQKFSPTSYVEEHKQIAQRLSREQGVPASVILAIAMHESANGNSKVAKNLNNHFGIKGKNNSKTIRSSYKGYSSILDSYHDFVALLKRRTSTQKLFDKYDSDDYLQWINGIARSGYSHSKSWKSQVLGMIKRYGLDELDTPVSENKSRIANRLDADVSQGTSSKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ34</accession>
    <name>D7VJ34_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002142.1">
        <property type="nucleotide sequence ID" value="NZ_GL379779.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11003"/>
    <dbReference type="EnsemblBacteria" id="EFK59169">
        <property type="protein sequence ID" value="EFK59169"/>
        <property type="gene ID" value="HMPREF0766_11003"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084471_1_0_10"/>
    <dbReference type="OrthoDB" id="1948290at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="233" mass="26897" checksum="208870CBC25BF4B9" modified="2010-10-05" version="1">MYRLDVINKIIQKHNAKTYLEIGVQTGAVISKVNCTRKIGVDPEFLFRRSMKAKRLLGIYKFETYEMPSDQFFETKAQNVLKHGVDVVLVDGLHTYQQAKKDVENSLNYLNEGGVIIMHDCNPLNAAAGYAIREHFSEVTDKVKNWDLPGWQGQWNGDVWKTVADLIVTRPDLNVFTLDMDYGLGIVTRGKQEVSHSFTITDIEKGDFDFFDQNREQLINLKNPKYFFDFFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ73</accession>
    <name>D7VJ73_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, TatD family</fullName>
            <ecNumber evidence="1">3.1.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tatD</name>
        <name evidence="1" type="ORF">HMPREF0766_11042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.-" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000408.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11042"/>
    <dbReference type="EnsemblBacteria" id="EFK58926">
        <property type="protein sequence ID" value="EFK58926"/>
        <property type="gene ID" value="HMPREF0766_11042"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_4_0_10"/>
    <dbReference type="OrthoDB" id="915852at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="259" mass="29488" checksum="551977D5D67AAEDA" modified="2010-10-05" version="1">MPTPYILTDTHTHLYYHIGTPLMEEQMQRCFDRGIERIFLPNVNTESIPKVMDTVHAYPQNCFPMLGLHPCDVKKNYREELLSIEKALSTHKVYAIGEIGLDLYWDKTTLDIQKEAFRIQVQWAKDLRLPIDIHCREAFDELFELLDELKDDKLFGVLHCFTGTLDQAKRAIDLGFALGIGGVVTYKKSGLDAVVKEIDLEHIVLETDAPYLAPVPFRGKPNESSYLHYIAEKVADLHEVGIEKVAAVTTANSKRIFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJC7</accession>
    <name>D7VJC7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000573.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11096"/>
    <dbReference type="EnsemblBacteria" id="EFK58980">
        <property type="protein sequence ID" value="EFK58980"/>
        <property type="gene ID" value="HMPREF0766_11096"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3528">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055418_1_0_10"/>
    <dbReference type="OrthoDB" id="1111569at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018707">
        <property type="entry name" value="LpxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037107">
        <property type="entry name" value="Put_OMP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09982">
        <property type="entry name" value="DUF2219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="315" mass="36363" checksum="39A64A2AA17E190F" modified="2010-10-05" version="1">MLFKINRFICRFSIGFVVFTMFLSSAFSQERLPHLLEFQSDNDVYLMNGQDRYYTNGLIVTYSVPLQQKSDRRTDILSFQLGHQLYNGIEVQAGNSLYWDRPSTAYLFLNGEFQRVYGDEWVWTAKAEVNVIGKGAKGKEVQKYVHRLLSMYEVESWASELNTSVGADVESKLSKKIWRSTSNKLELSGGGTLRAGMAFSHASAQVTLRFGKLADYYTSHFTKTGGFLNTDNEYYLFYTPSYTYQLYNATIQGGPFSRDKQKFYEIEPYIMKHYIGGAWSNRKIYVDAGFVFNTKEGKKMYSNHQYGTIRLGLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJG4</accession>
    <name>D7VJG4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000631.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11133"/>
    <dbReference type="EnsemblBacteria" id="EFK59017">
        <property type="protein sequence ID" value="EFK59017"/>
        <property type="gene ID" value="HMPREF0766_11133"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50337CK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1022718_0_0_10"/>
    <dbReference type="OrthoDB" id="1309807at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025396">
        <property type="entry name" value="DUF4302"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14135">
        <property type="entry name" value="DUF4302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="275" mass="30419" checksum="DC1928D1B1A7EF50" modified="2010-10-05" version="1">MKLKIYSLLITLLVLGASCDKKRDRVFEESPTERLNVSVDQAYSILKSQSNGWLVKYYPSSTLEFGGYTLFAKFSSSTEVNLQGDYTTNNATSMYTVYPGAGPILTFDTYNPVIHYFALPGAYFSPQIGAVDSGHKGDFEFLVVKATPDSVILQGRKTMNKIVMLPISTTEAPTIVANYKAAVAKFHPRGAYKVEVGGESLTATFSTAATKRAFTVTGSTTIYSYRYTDKGLDFYKEYDIKGVKFKELTFVEPTGSYTRGYFENAEKTLKLVPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJI2</accession>
    <name>D7VJI2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000658.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11151"/>
    <dbReference type="PRIDE" id="D7VJI2"/>
    <dbReference type="EnsemblBacteria" id="EFK59035">
        <property type="protein sequence ID" value="EFK59035"/>
        <property type="gene ID" value="HMPREF0766_11151"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007706_1_0_10"/>
    <dbReference type="OrthoDB" id="1442292at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="313"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1023" mass="118360" checksum="5C7C21D60CF8694B" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJI9</accession>
    <name>D7VJI9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000673.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11158"/>
    <dbReference type="EnsemblBacteria" id="EFK59042">
        <property type="protein sequence ID" value="EFK59042"/>
        <property type="gene ID" value="HMPREF0766_11158"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025928_2_0_10"/>
    <dbReference type="OrthoDB" id="251905at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024302">
        <property type="entry name" value="SusD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12741">
        <property type="entry name" value="SusD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="528" mass="58877" checksum="D3F7D8E3FFD568E0" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJS5</accession>
    <name>D7VJS5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000882.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11244"/>
    <dbReference type="EnsemblBacteria" id="EFK59128">
        <property type="protein sequence ID" value="EFK59128"/>
        <property type="gene ID" value="HMPREF0766_11244"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026001_0_1_10"/>
    <dbReference type="OrthoDB" id="637794at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014917">
        <property type="entry name" value="DUF1800"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08811">
        <property type="entry name" value="DUF1800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="589" mass="67053" checksum="D2215ECABCB281DC" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK13</accession>
    <name>D7VK13_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11332</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998828.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11332"/>
    <dbReference type="EnsemblBacteria" id="EFK58615">
        <property type="protein sequence ID" value="EFK58615"/>
        <property type="gene ID" value="HMPREF0766_11332"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_1_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="221"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="685"/>
            <end position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1147" mass="128761" checksum="111E4A1C26E04129" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK51</accession>
    <name>D7VK51_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BNR/Asp-box repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998929.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11370"/>
    <dbReference type="EnsemblBacteria" id="EFK58653">
        <property type="protein sequence ID" value="EFK58653"/>
        <property type="gene ID" value="HMPREF0766_11370"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024620_1_0_10"/>
    <dbReference type="OrthoDB" id="1293876at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sialidase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="398" mass="44084" checksum="C514DDFBFFEE7412" modified="2010-10-05" version="1">MKRNLLIALLSGGILMNISFVPESATDKMTKEGEEKIVFASGKDGYESYRIPAIIKAANGDILAFGEGRVAHAGDYGDIDIVMKRSKDQGRTWSALQKVVDFGNLQAGNPAPVLDMTDPQYPKGRIFLFYNTGNNHEGEIRKGNGVREVWYVTSTDQGETWSAAVNITTQVHRPNAPAFHPAYTFKEDWRSYANTPGHAMQFESGKYKGRIFVSANHSAGNPRAAFKDYQAHGYYTDDHGKTFHLGATVQAEGGNESIAAQISGDRLLMNSRNQQGQVRNRLISVSTDGGTTWDTTYFDKHLPDPVNQGSILSVSGKKQLLAFSNAASKTQRDSLTLRMSKDDGKTWFYNKRIATAPAGYKGDYAAYSDLVQLDAKKIGVLYEKDNYKNIVFLPVKWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK94</accession>
    <name>D7VK94_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11413"/>
    <dbReference type="EnsemblBacteria" id="EFK58696">
        <property type="protein sequence ID" value="EFK58696"/>
        <property type="gene ID" value="HMPREF0766_11413"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZG2B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2994404_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107319" evidence="2">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="57" mass="6682" checksum="C2D1BEE540BD77D8" modified="2010-10-05" version="1">MRAWLLILMMGIANFVFAQHETDRQDHSTLGYLVIGLILIAVVVFTLYNKQKRRFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKB2</accession>
    <name>D7VKB2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger domain protein, LSD1 subclass</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999088.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11431"/>
    <dbReference type="EnsemblBacteria" id="EFK58714">
        <property type="protein sequence ID" value="EFK58714"/>
        <property type="gene ID" value="HMPREF0766_11431"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1996">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039030_1_0_10"/>
    <dbReference type="OrthoDB" id="1472466at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="374" mass="42436" checksum="4C767AC33037FECB" modified="2010-10-05" version="1">MAFEEKTAEINKTFKCTGCSAPLAYKPGTDYLLCPYCGTRNTIAQTAENAPPLTFPIDYEHYIASIKDVNDNRYEELQEIAKCTNCGASTTLPSHVVAAKCAFCSSPLVIDHHTEHIVRPQALVPFFIDNKLAYQQFKIWGGKRWFAPNDFKRIFDTYSLNALKGVYIPFWVFNANTVTDYTGERGDHYYVERTVRDKDGNTTTVQDQRTRWRYASGRVSVTFKDITICASQSLSQASSDKLGPWHLERLVPFNEQYISGFSAQTYQLDPQAAMAEAKAVMQYQIRGYIKDDIGGDEQRIDSADTYFSKEGIRYVLLPVWLTSYKYNGKYYQIMINAFSGKVYGDRPYSTWKIVGAILLGIIILYIIGLFLGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKD8</accession>
    <name>D7VKD8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999159.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11457"/>
    <dbReference type="EnsemblBacteria" id="EFK58740">
        <property type="protein sequence ID" value="EFK58740"/>
        <property type="gene ID" value="HMPREF0766_11457"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044987_0_0_10"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="383"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="479" mass="53602" checksum="AC2273F0573E2216" modified="2010-10-05" version="1">MLLRAGLYLLSTFTLYDMYLKIIASGILCLGFTLVQGQILTLPDAAERSVQNYHKIKAKKSLTDAASENVSFRKSMYLPDVTAMVQQSFGSVNAQNGPLYAYGGLGVASTSMPLAEQNWNSAFGSLYLANINWNIFTFGRLKSELSAARAGYQVQVSDLDQEIFQHQIKVGAAYLNLVASQRLRYVQERNLYRAQVFYEMTESRANSGLIPEVDASLAKAEVSNARSAQIKAHDKVLAYSTDLAVLMGEPFQHYSIDSLYYTSEPPAALVSGLSAGQHPALLFQQHKIDESVEQEKVALATKRPSLSAFGVIQGRGTGFDWNYVQDNSAYSSSYWKGAGIDRGNYIIGFNLSWNISNIFRNDHKKKQQQYLTQAFRHDYERMNEELLAQEALANAQYANARDNLKETKVQLESATLAYQQHSALYENGLTTLIDFTQALYTLNRAEIEYEIAKNNIWQALLLQSAANGDLNLFLYSRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKJ7</accession>
    <name>D7VKJ7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mutator mutT protein</fullName>
            <ecNumber evidence="4">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mutT</name>
        <name evidence="4" type="ORF">HMPREF0766_11516</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999332.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11516"/>
    <dbReference type="EnsemblBacteria" id="EFK58799">
        <property type="protein sequence ID" value="EFK58799"/>
        <property type="gene ID" value="HMPREF0766_11516"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_19_3_10"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="131" mass="15250" checksum="2E8486E24E2CA647" modified="2010-10-05" version="1">MLYVTCALIIHQEKILICQRSEKMKLPLKWEFPGGKIEAGESKKDCLIREIKEELHLDIEVNEPLQMVEHHYIDFSLQLFPFVCTVIAGELTPQEHAQAIWVSRQQLMNYDWAEADIPIVKEFLSGNIIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKZ1</accession>
    <name>D7VKZ1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiol peroxidase</fullName>
            <shortName evidence="2">Tpx</shortName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peroxiredoxin tpx</fullName>
            <shortName evidence="2">Prx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Thioredoxin peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">tpx</name>
        <name evidence="4" type="ORF">HMPREF0766_11660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxiredoxin family. Tpx subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999648.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11660"/>
    <dbReference type="EnsemblBacteria" id="EFK58264">
        <property type="protein sequence ID" value="EFK58264"/>
        <property type="gene ID" value="HMPREF0766_11660"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_12_2_10"/>
    <dbReference type="OrthoDB" id="1738458at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03014">
        <property type="entry name" value="PRX_Atyp2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00269">
        <property type="entry name" value="Tpx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002065">
        <property type="entry name" value="TPX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018219">
        <property type="entry name" value="Tpx_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01265">
        <property type="entry name" value="TPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="18"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="2">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="166" mass="17770" checksum="6C246440E07F3D44" modified="2010-10-05" version="1">MATITFKGSDVHTQGDLPKVGSQAPDFKLTAGDLSDKSLTDFKGKRVVLNIFPSIDTGTCAASVRAFNKAAADLDNTTVLCISKDLPFAQGRFCAAEGISNVLTLSEYKDSSFSDAYQLRLTDGPLAGLLSRVVIVLDEEGKVVYEEQVSEIVNEPDYDAALATLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL22</accession>
    <name>D7VL22_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase, family 88</fullName>
            <ecNumber evidence="4">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11691</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999729.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11691"/>
    <dbReference type="EnsemblBacteria" id="EFK58295">
        <property type="protein sequence ID" value="EFK58295"/>
        <property type="gene ID" value="HMPREF0766_11691"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027158_0_0_10"/>
    <dbReference type="OrthoDB" id="859760at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005672213" evidence="3">
        <location>
            <begin position="20"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610905-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610905-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="403" mass="45937" checksum="0D9F9A0C52449804" modified="2010-10-05" version="1">MKGLISIIVLMCVSVILTAQTKTGQNKGKLHLPATYVDTQLKDAVKQYKYMATRLNEPGRLPKTYYANKDSLETSGPEWWTSGFYPGTLLYLYEYAGDSVLKAEADKVLRILEKEKDDKTTHDLGFMLYCSFGNANRLQLSAHYKQILLTGAESLISRFNSKVGCIKSWDLVNSKWQFPVIIDNMMNLEFLNWASRESGDQKYINISKTHANTTLKHHFRDDYSSYHVVDYDSISGEVRNRHTAQGARHESAWARGQTWGLYGYTMMYRDTKDVTYLNQAIHIAEFILNHPNLPKDGIPYWDFNADNIPDAKRDASAAAIMASALLELQSYVNKEQQEKYLLAAEKMLKSLGSKNYKAENGTNGGFILEHSVGHIPANFEIDVPLTYADYYYVEALMRYKALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL32</accession>
    <name>D7VL32_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fadB</name>
        <name evidence="10" type="ORF">HMPREF0766_11701</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999743.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11701"/>
    <dbReference type="EnsemblBacteria" id="EFK58305">
        <property type="protein sequence ID" value="EFK58305"/>
        <property type="gene ID" value="HMPREF0766_11701"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010448_0_0_10"/>
    <dbReference type="OrthoDB" id="82358at2"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="9">
        <location>
            <begin position="8"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="8">
        <location>
            <begin position="209"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="8">
        <location>
            <begin position="387"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK58305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="809" mass="90041" checksum="A8195BFE475F09EE" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL43</accession>
    <name>D7VL43_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11712"/>
    <dbReference type="EnsemblBacteria" id="EFK58316">
        <property type="protein sequence ID" value="EFK58316"/>
        <property type="gene ID" value="HMPREF0766_11712"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2883622_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="63" mass="7187" checksum="4DF38D4F966935E1" modified="2010-10-05" version="1">MLKLTIKSETYSLNIIIMVLQLIYGRISSNHLQLLLIKFTSLSSLFTITGVKGEIILQNTKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL80</accession>
    <name>D7VL80_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999855.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11749"/>
    <dbReference type="EnsemblBacteria" id="EFK58353">
        <property type="protein sequence ID" value="EFK58353"/>
        <property type="gene ID" value="HMPREF0766_11749"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50340SB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1926231_0_0_10"/>
    <dbReference type="OrthoDB" id="2139913at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="131" mass="15549" checksum="10559517987245BD" modified="2010-10-05" version="1">MERINIIYDVYQRAIGNYTVSIRSFYSAETKLGIGLFVNEIETPLFYYKTDKSNSIPYLGFNHSQIKVFMESDNYENKNVESRFINFTSLIKMFEFYAYAHFDAKPQEFITENQVYIAYITAFEKKMSLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL92</accession>
    <name>D7VL92_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999895.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11761"/>
    <dbReference type="EnsemblBacteria" id="EFK58365">
        <property type="protein sequence ID" value="EFK58365"/>
        <property type="gene ID" value="HMPREF0766_11761"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_507965_0_0_10"/>
    <dbReference type="OrthoDB" id="62271at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026341">
        <property type="entry name" value="Bac_Flav_CTERM"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04131">
        <property type="entry name" value="Bac_Flav_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="529" mass="58220" checksum="79E9AE7F1A2E8F90" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLB4</accession>
    <name>D7VLB4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD linked oxidase, C-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_11783</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999962.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11783"/>
    <dbReference type="EnsemblBacteria" id="EFK58387">
        <property type="protein sequence ID" value="EFK58387"/>
        <property type="gene ID" value="HMPREF0766_11783"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010756_0_0_10"/>
    <dbReference type="OrthoDB" id="1034540at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="33"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="974" mass="109431" checksum="4E4C635BAE0E15F1" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLB8</accession>
    <name>D7VLB8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Diadenylate cyclase</fullName>
            <shortName evidence="10">DAC</shortName>
            <ecNumber evidence="10">2.7.7.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic-di-AMP synthase</fullName>
            <shortName evidence="10">c-di-AMP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dacA</name>
        <name evidence="12" type="ORF">HMPREF0766_11787</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably a homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate cyclase family. DacA/CdaA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="10"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999975.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11787"/>
    <dbReference type="EnsemblBacteria" id="EFK58391">
        <property type="protein sequence ID" value="EFK58391"/>
        <property type="gene ID" value="HMPREF0766_11787"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038561_0_0_10"/>
    <dbReference type="OrthoDB" id="1300262at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01499">
        <property type="entry name" value="DacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014046">
        <property type="entry name" value="C-di-AMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034701">
        <property type="entry name" value="CdaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045585">
        <property type="entry name" value="CdaA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19293">
        <property type="entry name" value="CdaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004793">
        <property type="entry name" value="UCP004793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00159">
        <property type="entry name" value="TIGR00159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="DAC" evidence="11">
        <location>
            <begin position="81"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK58391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="261" mass="29190" checksum="50318056D3E5C18E" modified="2010-10-05" version="1">MDSSFLSGFRLLDIVDILLVAIIIYYVYSLIRGTIAVNILIGVALFYGIYLIVKQMEMRLLTEIFGGFISVGSIALIVVFQQEIRRFLLHVGKNISMKRKKYLWSFLGNKKAVASENTEFLRPIIDACRSMSKSRTGALLVFAKYFDEEYYQSSGELIDAHISKRLIESIFNKLSPLHDGAVVIVDNKIMSASCVLPLSDSEDLPLQFGLRHRAAIGVTEISDAIAVVVSEETGEISFAKDGNVNMNITHEELEELLKAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLN9</accession>
    <name>D7VLN9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribonuclease HII</fullName>
            <shortName evidence="11">RNase HII</shortName>
            <ecNumber evidence="11">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">rnhB</name>
        <name evidence="14" type="ORF">HMPREF0766_11909</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11 12">Belongs to the RNase HII family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="11"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000274.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11909"/>
    <dbReference type="EnsemblBacteria" id="EFK58512">
        <property type="protein sequence ID" value="EFK58512"/>
        <property type="gene ID" value="HMPREF0766_11909"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036532_3_1_10"/>
    <dbReference type="OrthoDB" id="1685277at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_B">
        <property type="entry name" value="RNase_HII_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="13">
        <location>
            <begin position="13"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFK58512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="198" mass="22313" checksum="F26A509DF644C6B4" modified="2010-10-05" version="1">MLLSTFQIERIEAGCDEAGRGCLAGPVFAAAVIFPKDYHHDLLNDSKKLSEKKRMALRPIIEQEALAFAVASVSAEEIDKINIHNASYLAMHRALDQLQVKAEYIIVDGNRFIPYPEVSHTCIIKGDGKYLSIAAASILAKTYRDEYMESIACDFPAYDWLQNKGYPTVKHRNAVLAYGLTPHHRKTFRITDPQLKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLQ9</accession>
    <name>D7VLQ9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11929"/>
    <dbReference type="EnsemblBacteria" id="EFK58532">
        <property type="protein sequence ID" value="EFK58532"/>
        <property type="gene ID" value="HMPREF0766_11929"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50325AS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100905_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107668" evidence="1">
        <location>
            <begin position="24"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="216" mass="24205" checksum="3AFDABA713B53C4E" modified="2010-10-05" version="1">MVKNPKHIVFTILLICSSFFSFAQEKKIVQFSGIIHAIGSELPVPFVTIRNGDRQDQVFVANHEGFFSFVAHVGDTVRFSSIGYDPTEFVVPNTSEDKYTAAIQMKSLVKELPMVTPFPWASIEEFNMAFMALRVGDDAITTARRSVSPEALAALARITPRSAEEIQNFNSTQRHIGLTNKAINQKYANPLLNPFAWGSLINDIFKGDDSRKKLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLV4</accession>
    <name>D7VLV4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK57959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001015.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11951"/>
    <dbReference type="EnsemblBacteria" id="EFK57959">
        <property type="protein sequence ID" value="EFK57959"/>
        <property type="gene ID" value="HMPREF0766_11951"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_962794_0_0_10"/>
    <dbReference type="OrthoDB" id="1003186at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107029" evidence="1">
        <location>
            <begin position="29"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="309" mass="34625" checksum="5923971CD7076917" modified="2010-10-05" version="1">MTNQRRSFLKRSSVLLSSILLARPLAGAAQSSKKISSLADNKRLIIYQTNDLSSINYWSRYKEILETLDAEPTSGLILDAGNLFDASADVFQNKKRLAKLNKIGFHAAACSNIYLNKGEEGLADMLSAINFPLICSNYQFSDARLQKGILPYMIIHSKGQKIGIIAVAQNTEIPDVSVQNPYKSAEKISKLLKEQENCNLVICLSQLGMDRKQWNSYDLAQETSYVDMILSNSVGNKVNGTLVLRNKAKNEVILSQSLDSGQLLSKNILGYDDDNNRQSYNHEYLMPANHYASNKEIYKELFLVKQQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLX4</accession>
    <name>D7VLX4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Outer membrane insertion signal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK57979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001079.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57979">
        <property type="protein sequence ID" value="EFK57979"/>
        <property type="gene ID" value="HMPREF0766_11971"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZW7X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1141359_0_0_10"/>
    <dbReference type="OrthoDB" id="1298818at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="248" mass="27651" checksum="3A4CAC96AEA256E0" modified="2010-10-05" version="1">MNRFAAVVLLFSVLVLILSSCSSIYMPNVPATPMFSKQGEGYLSGHVNLKGNVSGNAGVAISDHIGIIANGSYVNHKKQIKEFKQYLYEGGLGYFTTIGKSKRQIFEVYAGYGIGNSVETDLRSTTTGMQPVEIRDMDFEKIFVQVNYSSTKKDKINLFGAKRELNYGTAIRMSRVAMKDFTIDAVDAEKEDNIFIEPVFFTRLALNRNWQLQYTTGFNIGVNSNEYLKAGNAVFTLGVSYNFGKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLY5</accession>
    <name>D7VLY5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK57990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001111.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11982"/>
    <dbReference type="EnsemblBacteria" id="EFK57990">
        <property type="protein sequence ID" value="EFK57990"/>
        <property type="gene ID" value="HMPREF0766_11982"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032SSE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_185106_0_0_10"/>
    <dbReference type="OrthoDB" id="1939105at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="97" mass="11324" checksum="D0FCC32C04E945D9" modified="2010-10-05" version="1">MDKLKKFELMEKIVRELEDVRNSQQAVLEKIGKIEVDNIELGDKNLENTLPDIYQRTADNSDAIRDLLNSFQEKTDDFGEKNNVDKLKEQQQINSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM48</accession>
    <name>D7VM48_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_12045</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001292.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12045"/>
    <dbReference type="EnsemblBacteria" id="EFK58053">
        <property type="protein sequence ID" value="EFK58053"/>
        <property type="gene ID" value="HMPREF0766_12045"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_106_2_10"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005672198" evidence="4">
        <location>
            <begin position="20"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="168"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="464"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="363"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="652" mass="74928" checksum="F6851146A49E1B25" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM82</accession>
    <name>D7VM82_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Glutamate racemase</fullName>
            <ecNumber evidence="2 7">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">murI</name>
        <name evidence="8" type="ORF">HMPREF0766_12079</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Provides the (R)-glutamate required for cell wall biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2 7"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001364.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12079"/>
    <dbReference type="EnsemblBacteria" id="EFK58087">
        <property type="protein sequence ID" value="EFK58087"/>
        <property type="gene ID" value="HMPREF0766_12079"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052344_0_3_10"/>
    <dbReference type="OrthoDB" id="1718671at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033134">
        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="15"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="47"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="79"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="195"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="275" mass="31017" checksum="8C3D7D4587627179" modified="2010-10-05" version="1">MSNTVFHNSPIGVFDSGYGGLSVFKEIKKELPEYDYIYLGDNARIPYGNRSFETVYQFTKECVFKLFDLGCDLVILACNTASAKALRSIQQHDLPPGKKVLGVIRPTTEIIKKYTITNKIGILATTGTVKSESYKIEINKFYPEIEVFQHDCPFWVPLVENNEIDTEGARYFVEKDIHELLSQSSEIDTIVLACTHYPLLLPVIKQFVPPHIQIISQGPIVAHSLKNYLERHPEVEQSCSKGSTLQFFTTDDASGFEEKAEIFFGHPVKASTIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMH9</accession>
    <name>D7VMH9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD hydrolase, family IA, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001560.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12176"/>
    <dbReference type="EnsemblBacteria" id="EFK58184">
        <property type="protein sequence ID" value="EFK58184"/>
        <property type="gene ID" value="HMPREF0766_12176"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_4_10"/>
    <dbReference type="OrthoDB" id="1167152at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="219" mass="25016" checksum="516A822E698CED5A" modified="2010-10-05" version="1">MSQYAVIFDMDGVICHTNPYHAKAFEAFFNKYNIESSEQEFQDHMYGKHNSYIMSYFFKRPVEGEELLRLEFEKEDMFRQIYKSEITPIARFPEFLDELKQEGFKTAVATSAPKANLDLIVEGLQFGPKMESMLSSENVTKHKPDPQVYLLTAERLGVYPSQCLVFEDSYSGISAALNAGMKVVGVLSSHTREQLPPCDAYISDYTEITAQKVKELINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VML5</accession>
    <name>D7VML5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioesterase family protein</fullName>
            <ecNumber evidence="5">3.1.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_12235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992670.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12235"/>
    <dbReference type="EnsemblBacteria" id="EFK57162">
        <property type="protein sequence ID" value="EFK57162"/>
        <property type="gene ID" value="HMPREF0766_12235"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050164_3_2_10"/>
    <dbReference type="OrthoDB" id="1712258at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="175" mass="19878" checksum="4AC9A301E2542F64" modified="2010-10-05" version="1">MKSKTAKESYMVMNELVLPNDTNTFNNLMGGRLLYWMDICSAMAAQKHANSPVVTVSVDNVSFKRSIKLGEVLTIEAQVTRAFNTSLEVRMEVFAQNLPLGTKVKSNEAYYTFVAVDEHTQPQPIPELIPETEKEHKLYDEALQRRELRLILAGKIKPQHATGIKKLLKMLEQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMP2</accession>
    <name>D7VMP2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_12262</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992718.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12262"/>
    <dbReference type="EnsemblBacteria" id="EFK57189">
        <property type="protein sequence ID" value="EFK57189"/>
        <property type="gene ID" value="HMPREF0766_12262"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_1_1_10"/>
    <dbReference type="OrthoDB" id="233664at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005672180" evidence="5">
        <location>
            <begin position="23"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="SusD-like_3" evidence="7">
        <location>
            <begin position="73"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="6">
        <location>
            <begin position="342"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK57189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="590" mass="66598" checksum="67DD8C3C35AAC672" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMV0</accession>
    <name>D7VMV0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable potassium transport system protein kup</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">kup</name>
        <name evidence="12" type="ORF">HMPREF0766_12320</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Transport of potassium into the cell.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the HAK/KUP transporter (TC 2.A.72) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992816.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12320"/>
    <dbReference type="EnsemblBacteria" id="EFK57247">
        <property type="protein sequence ID" value="EFK57247"/>
        <property type="gene ID" value="HMPREF0766_12320"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008142_4_1_10"/>
    <dbReference type="OrthoDB" id="589903at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01522">
        <property type="entry name" value="Kup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023051">
        <property type="entry name" value="K+_uptake_low_affin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="PTHR30540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="280"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK57247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="647" mass="72529" checksum="860E68077A9AE72F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMZ0</accession>
    <name>D7VMZ0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-type ATPase subunit b</fullName>
            <shortName evidence="11">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">atpF</name>
        <name evidence="14" type="ORF">HMPREF0766_12360</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="10 11">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the ATPase B chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992878.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12360"/>
    <dbReference type="EnsemblBacteria" id="EFK57287">
        <property type="protein sequence ID" value="EFK57287"/>
        <property type="gene ID" value="HMPREF0766_12360"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079215_4_1_10"/>
    <dbReference type="OrthoDB" id="1999641at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="46"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFK57287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="166" mass="18827" checksum="BA1D9B8A78703C66" modified="2010-10-05" version="1">MEALINQFSYGLFFWQLIILLIVIFILGKFAWKPIVNALDERETGISNALAAAEKAKLEMTRLTNENEQLLKEARAERDLILKEAKELKEKIVIEARDQAHAEGKRLIAQAKQEIDTQKTKALAEVKAQVSELSIEIARKVLSKEFEDQGKQQALVADLLKDVKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN52</accession>
    <name>D7VN52_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992961.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12422"/>
    <dbReference type="EnsemblBacteria" id="EFK57349">
        <property type="protein sequence ID" value="EFK57349"/>
        <property type="gene ID" value="HMPREF0766_12422"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1980154_0_0_10"/>
    <dbReference type="OrthoDB" id="2092524at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="126" mass="14381" checksum="D7E112A1F30009C7" modified="2010-10-05" version="1">MFNKIDNAFDKIANSKWLKFGIGTVIIIFIMDQCFKKTPDAPKNKIENQLSNFDGSLIKFREYIKNNLNDPSSFEHVETRYKDNGDGTASVYMKYRGKNAFNATLTKIAKCTLNVSTGNFYDVVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN86</accession>
    <name>D7VN86_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_12456</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12456"/>
    <dbReference type="EnsemblBacteria" id="EFK57383">
        <property type="protein sequence ID" value="EFK57383"/>
        <property type="gene ID" value="HMPREF0766_12456"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024927_6_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="5">
        <location>
            <begin position="129"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK57383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="216" mass="25380" checksum="8A7EE0B13206DC6A" modified="2010-10-05" version="1">MMNLTDKLTITNEDNMVMMSRYPEKYFDLAIVDPPYGIGPDWKKRKNTADKYKGSYQNESIPDEKYFNELIRVSKNWIVWGWNYYTQFFPPTNYLIVWDKKMSDKTSFSSQVEIAATSIKIPAAIYRHSWDGARKESETGIDKIHPHQKPVALYKWLLDKYAKPGYKIIDTHFGSGSIAIACHDYGYELTACELDQEYYQSAIDRIRRHTNQLQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNA5</accession>
    <name>D7VNA5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993027.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12475"/>
    <dbReference type="EnsemblBacteria" id="EFK57402">
        <property type="protein sequence ID" value="EFK57402"/>
        <property type="gene ID" value="HMPREF0766_12475"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036343_0_0_10"/>
    <dbReference type="OrthoDB" id="1070946at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="308" mass="36227" checksum="C212F30221781F88" modified="2010-10-05" version="1">MMEKKVLSNPSVGKTSTIRLNARKNGEPLRVLSEEDWNFWSHNGYIVIKNAVPKSQAKRLADYLWQYENKNPDDPETWYRSSAQIEMSELNNTGMVEIYNHQYLWDNRQFPKIHQAFADVWGTEKLWTTIDRANLNFPIRPGHEYKGFIHWDYDPETDPQNVQGVLALADQTDENMGGFQCIPELFREYDTWKLTQPKDRDYFRPDTTGFTTTKVKMEAGDLLIFHSRQPHGIRPNNSDHKVRMAQYISMMPAEESNEEMREWRIRSWKEKIVPRGYAFPGDPLEREKAQPVAELTELGKKLLGLEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNL8</accession>
    <name>D7VNL8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conjugative transposon TraK protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">traK</name>
        <name evidence="2" type="ORF">HMPREF0766_12588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993173.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12588"/>
    <dbReference type="EnsemblBacteria" id="EFK57515">
        <property type="protein sequence ID" value="EFK57515"/>
        <property type="gene ID" value="HMPREF0766_12588"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3701">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088153_0_0_10"/>
    <dbReference type="OrthoDB" id="1169021at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022276">
        <property type="entry name" value="Conjug_transposon_TraK"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03781">
        <property type="entry name" value="Bac_Flav_CT_K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="207" mass="24219" checksum="6F8E41EC7C20A3FD" modified="2010-10-05" version="1">MEFKTLRNIENSFRQIRLYAIVFAVLCTSVVGYAVWRSYRFAEEQRQKIYVLDNGKSLMLALSQDASINRPVEAREHVRRFHELFFTLAPDKNAIESNMSRAFNLADKSAFDYYKDLSEKGYYSRIISGNVQQRIEVDSVVCNFDNYPYAVRTYAKQFIIRSSNVTRRNLITSCYLVNSVRSDNNPQGFNIEKFAVVENRDIEVIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNS7</accession>
    <name>D7VNS7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF305 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12647</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993268.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12647"/>
    <dbReference type="EnsemblBacteria" id="EFK57574">
        <property type="protein sequence ID" value="EFK57574"/>
        <property type="gene ID" value="HMPREF0766_12647"/>
    </dbReference>
    <dbReference type="GeneID" id="66688601"/>
    <dbReference type="eggNOG" id="COG3544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113754_1_0_10"/>
    <dbReference type="OrthoDB" id="1381270at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="DUF305" evidence="3">
        <location>
            <begin position="117"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="174" mass="19957" checksum="BE52FCFA00F067EB" modified="2010-10-05" version="1">MENMQNSHHAGHSSEHGTHNTKHASAMYKRFAVMAVAMFAVMYFIMYAMIDGWQNLIPNINNLYMTLLMTSAMLLIELAIMKVMYPNRKMNWAIAIISVAVGIFSWFGIREQINVGDKQFAKGMIPHHAAAILMSEKAHLTDPELIELQKNILKTQAEEIELMKRKLKEFEESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP62</accession>
    <name>D7VP62_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993487.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12782"/>
    <dbReference type="EnsemblBacteria" id="EFK57709">
        <property type="protein sequence ID" value="EFK57709"/>
        <property type="gene ID" value="HMPREF0766_12782"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_2_10"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="3"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="180"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="394" mass="44408" checksum="A6A3E849D60D1774" modified="2010-10-05" version="1">MEAAKLLKAIIDHAIDGIITIDNKGIVESINPAASSLFGYSPEEVIGHNISILMPEPDRSNHDSYIHNYKETGQKKIIGIGREVLGRRKDGSTFPFRLAVSEVFYEHKNVFTGFIHDLSKEKAAEDKLLKHALELEQRIRERTKDLIKTVSELEKAKAEVSNSLEKEKELGQMKSRFVSMASHEFRTPLSSIQLSASLIEKYIEKPDFLNVRKHTSRIKGSVQLLTNILNDFLSLEKLEAGVVAVQKERINLVTLAEEITEEMQMICKKNQHIVYEHTGTEAEFMMDAHLWKSIAINLISNAVKYSGEDTFIEFSTMIQGNICTVSIKDNGIGIPEEDQVNLFEPFFRAHNTGNIPGTGLGLNIVRRYVELLGGNLVYRSVINEGTSFLLTFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPF3</accession>
    <name>D7VPF3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12873"/>
    <dbReference type="EnsemblBacteria" id="EFK57800">
        <property type="protein sequence ID" value="EFK57800"/>
        <property type="gene ID" value="HMPREF0766_12873"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3239795_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="43" mass="5251" checksum="CE05CDB09640A521" modified="2010-10-05" version="1">MKYYVYRSCEYIETFIEFGIFSFVDSLLNSLFQENKKNQLDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPI9</accession>
    <name>D7VPI9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III, delta subunit</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">holA</name>
        <name evidence="2" type="ORF">HMPREF0766_12909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993747.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12909"/>
    <dbReference type="EnsemblBacteria" id="EFK57836">
        <property type="protein sequence ID" value="EFK57836"/>
        <property type="gene ID" value="HMPREF0766_12909"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044694_3_0_10"/>
    <dbReference type="OrthoDB" id="1199768at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="1">
        <location>
            <begin position="19"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="334" mass="37843" checksum="B38424BB0D84EC89" modified="2010-10-05" version="1">MNVSPILSDIKNKKLKPVYLLHGEEPYFIDLISDTIESSVLDDAQKGFDQTILYGKDTDFITIVNAAKRYPMLSDHQVILIKEAQDLKWKQGEELLLNYVEHLTPSTVLVFNYKYGKFDKRKKLYKAIEKAGEVVESNKLYEDKVAGWITSYVKDHGWSIHPQAAAMMAEYLGTDLSKVSNELDKLMLNVPKSTEIGAGDIELNIGISKDFNVFELNTALAKRNALKAYQIVDYFAANPKNNPLVVVLGAMGGYFTKVLKYHYLPDKSAAAKELGVHPFFIKEYEIAARNYNRRKTFDIINHLKEADLKSKGMNVGSNTGTDDILREMIFNILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPK3</accession>
    <name>D7VPK3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Abhydrolase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993777.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12923"/>
    <dbReference type="EnsemblBacteria" id="EFK57850">
        <property type="protein sequence ID" value="EFK57850"/>
        <property type="gene ID" value="HMPREF0766_12923"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_4_6_10"/>
    <dbReference type="OrthoDB" id="1470522at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="60"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="271" mass="30837" checksum="DB24D0F8468F18A3" modified="2010-10-05" version="1">MKQSTLLAVFLLLFQGMLLAQYNLKKDVTYYPETKSKTAEYERCKLDFYYPVDKKDFATILWFHGGGLTGGQKEIPEYLKNRGMAVVGVGYRLSPQANVESIIEDAAAAIAWVFNHIEEYGGSRRLVFVSGHSAGGYLGMMTTLDKQYLQKYTIDANQIAGLIPFSGQAITHFTSRQEQGIGEKQPTIDRFAPLFHVRQDAPPILLITGDRELEMLGRYEENAYLQRMLKISGHKDVRLLELQGFGHNMQYPAYPLLIKEVEERTKKILQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPS4</accession>
    <name>D7VPS4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993874.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12994"/>
    <dbReference type="EnsemblBacteria" id="EFK57921">
        <property type="protein sequence ID" value="EFK57921"/>
        <property type="gene ID" value="HMPREF0766_12994"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_816133_0_0_10"/>
    <dbReference type="OrthoDB" id="393971at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032320">
        <property type="entry name" value="GH18_DUF4849"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16141">
        <property type="entry name" value="DUF4849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107776" evidence="1">
        <location>
            <begin position="20"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="340" mass="38678" checksum="CF1F046061A1D356" modified="2010-10-05" version="1">MKKILIFLFCLYSLGNLFTGCTKWTDQETLIVQSLDADSNSLGSNYKKYLEKLRAYKQSAHPQAIGLFNTSNWKTDATQQSTFLYSLPDSLDMICLLNQDSLMTSEQKADMSSTQATKGTKMLMSFDLIRMNKRLKDRLPASPSKDEIATSINAYVDSMLNIYQQNKYNGIYIRYEDLYCFNCKEILSDIDLVSGLISRIAAANFSKKILFQFKGTDAVYLKDEAAARIDYFVLNSLNVKSTSYYEYDGFLEFFTKIKDFNPSKFILLASFEGDRWKMGGDEFPVGNSTFIGTSEALARWNVTGGKKGGLGIYYIEQDYKNNPPFKYSRNALQILNPAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPV6</accession>
    <name>D7VPV6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux transporter, outer membrane factor lipoprotein, NodT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993921.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13026"/>
    <dbReference type="EnsemblBacteria" id="EFK57953">
        <property type="protein sequence ID" value="EFK57953"/>
        <property type="gene ID" value="HMPREF0766_13026"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_13_3_10"/>
    <dbReference type="OrthoDB" id="1619477at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="375"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="490" mass="55569" checksum="C1D6A04107CDFDB5" modified="2010-10-05" version="1">MINKNRYSFTLILLLFTTLFVVQSCKIGEKYTRPDLNLPEQYRSDTLDYFGDTTTISRIPWREFFHDSTLLALIDSALINNFDMRTALLNTRIANRQVIQNKANYLPSVEATLANANRQWRSSDFGSGPSSRWYDKKQKDAPDDMFVYLSQFGTEVRFSWELDVWGKISSQQNQLLAQYLDTYEAKNAIQTNLISSIAKGYFNLLMLDDKIRVAKRNVQLNDSTLRMIRLQYEAGEITALAIQQTESQRLVAASLVPELEKEIAVQENALRTLTGQMPDRIQRGQSFEHLIAENQEISLGSPLEIVRNRPDIRSAEFQLISANAHTNVQQAMRYPALSIGGSLGVNAMLPKNWFNIPGALLGGISGDLTAPIFKNRTLKTNYEIAKLEREKAELALQQTVLEAVSEVSNSIITVEKQREQLEFAKKRVSNSELAVRNAGLLFRSGYATYLEVITAQSNALTSELDLVELRQKHLESYVDLYRSLGGGWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPZ5</accession>
    <name>D7VPZ5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="9">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">thrS</name>
        <name evidence="12" type="ORF">HMPREF0766_13049</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="9"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993962.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13049"/>
    <dbReference type="EnsemblBacteria" id="EFK55846">
        <property type="protein sequence ID" value="EFK55846"/>
        <property type="gene ID" value="HMPREF0766_13049"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_10"/>
    <dbReference type="OrthoDB" id="900765at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGS" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="242"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK55846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="641" mass="73067" checksum="F083DAFEC74F9A1F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ54</accession>
    <name>D7VQ54_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994051.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13108"/>
    <dbReference type="EnsemblBacteria" id="EFK55905">
        <property type="protein sequence ID" value="EFK55905"/>
        <property type="gene ID" value="HMPREF0766_13108"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50341WS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135650_2_0_10"/>
    <dbReference type="OrthoDB" id="2077602at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="110" mass="13009" checksum="200C45DB6D654505" modified="2010-10-05" version="1">MKKYCIYIASDSNRHHLEVNLTQDVETTYQEMRTVHASLFNQVIKLSSIVYIEYADTFEQAEKRRKELASLPRIVKERMVRKQNPNWKNLCSLHMPLTILHNKKAVAYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQG0</accession>
    <name>D7VQG0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5977 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994265.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13214"/>
    <dbReference type="EnsemblBacteria" id="EFK56011">
        <property type="protein sequence ID" value="EFK56011"/>
        <property type="gene ID" value="HMPREF0766_13214"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_236222_0_0_10"/>
    <dbReference type="OrthoDB" id="22313at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046020">
        <property type="entry name" value="DUF5977"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19404">
        <property type="entry name" value="DUF5977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5977" evidence="1">
        <location>
            <begin position="1680"/>
            <end position="1736"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1821" mass="202599" checksum="61A2FA442D24D270" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQR2</accession>
    <name>D7VQR2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CobW/P47K family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cobW</name>
        <name evidence="3" type="ORF">HMPREF0766_13316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994440.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13316"/>
    <dbReference type="EnsemblBacteria" id="EFK56113">
        <property type="protein sequence ID" value="EFK56113"/>
        <property type="gene ID" value="HMPREF0766_13316"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017452_2_0_10"/>
    <dbReference type="OrthoDB" id="1267701at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="257"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="398" mass="45557" checksum="3E0D9A6A3054E915" modified="2010-10-05" version="1">MKNKKLPVTVLSGFLGAGKTTLLNHVLHNKENLKVAVIVNDMSEINIDASLVKKENTLSRTEEKLVEMSNGCICCTLREDLMVEVERLAGENRFDYLLIESTGISEPLPVAQTFSFVDEQNGINLPDLSYIDTMVTVVDCFNFFKDFGSAETLTDRRLTDDDDNRTIVNLLTDQVEFANVIILNKVDLVAEETIGVLKAAIRKLNPVARIIQSSFGQIVVSDIIGTGLYNQSVAESSEAWKNELAQEHVPETEEYGISSFVFTTQRPFHPQRWYDYLNITYPHNLIRAKGLFWMASRPDEAISFSQAGGSLRLEGAGVWWCSIPESERRHYPDFREYEAEMTKRWHPEWEDRKTELVFIGQDLNKEVCVAQLEECLLTDEEAERWKYNEWVDNFPKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQS5</accession>
    <name>D7VQS5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polysaccharide lyase family 8, super-sandwich domain protein</fullName>
            <ecNumber evidence="7">4.2.2.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cslA</name>
        <name evidence="7" type="ORF">HMPREF0766_13329</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polysaccharide lyase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.5" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994454.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13329"/>
    <dbReference type="EnsemblBacteria" id="EFK56126">
        <property type="protein sequence ID" value="EFK56126"/>
        <property type="gene ID" value="HMPREF0766_13329"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004172_2_1_10"/>
    <dbReference type="OrthoDB" id="941406at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030341">
        <property type="term" value="F:chondroitin AC lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038970">
        <property type="entry name" value="Lyase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011071">
        <property type="entry name" value="Lyase_8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012970">
        <property type="entry name" value="Lyase_8_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004103">
        <property type="entry name" value="Lyase_8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003159">
        <property type="entry name" value="Lyase_8_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38481">
        <property type="entry name" value="PTHR38481"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02278">
        <property type="entry name" value="Lyase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02884">
        <property type="entry name" value="Lyase_8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08124">
        <property type="entry name" value="Lyase_8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49863">
        <property type="entry name" value="SSF49863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107244" evidence="3">
        <location>
            <begin position="20"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="Lyase_8_N" evidence="6">
        <location>
            <begin position="39"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Lyase_8" evidence="4">
        <location>
            <begin position="354"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Lyase_8_C" evidence="5">
        <location>
            <begin position="627"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="729" mass="83196" checksum="37E67C4C616D8CC3" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQY3</accession>
    <name>D7VQY3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994527.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13387"/>
    <dbReference type="EnsemblBacteria" id="EFK56184">
        <property type="protein sequence ID" value="EFK56184"/>
        <property type="gene ID" value="HMPREF0766_13387"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112936_0_0_10"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="156" mass="18160" checksum="016440CEA502B1CC" modified="2010-10-05" version="1">MPTIRIETLIKAPIERVFDLSRSIDLHQLSTHQTNEKAIAGRLSGLIELHETVTWRARHFGIYQKLSVAITAFDRPYRFEDKMLKGAFESMEHTHLFEQQAEGTNMIDIFTFKAPLGILGWVAEKLFLTAYMTDFLKKRNETIRSVAESEQWKQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR25</accession>
    <name>D7VR25_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994591.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13429"/>
    <dbReference type="EnsemblBacteria" id="EFK56226">
        <property type="protein sequence ID" value="EFK56226"/>
        <property type="gene ID" value="HMPREF0766_13429"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2819">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039834_1_0_10"/>
    <dbReference type="OrthoDB" id="1828423at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="397" mass="45006" checksum="22D5FD9AC073E90D" modified="2010-10-05" version="1">MVFKRILSLFFSYLIFVLPAFSQSKYQVIIEVKSTPATHRHSPLYITGNFNGWNPKLHMLDTLPSGTTPLHSRILLPEVKAGLLEFKFTRGDWQTLESTAIGTLTAPRNVMIQKDTVIRIDIAGWRDDFPASTASPQVHLLDSAFYIPQLAVKRAVWIYLPKDYATSDKKYPVLYMHDGQDLFDEATSQGRIGPLEWGVDEAIDRHRQSAIVVAVAHAESKEDRQNEYFVSPNSRFPNPQGAGYLKFIVHTLKPYIDSHYRTMPDKKHTAMAGSSVGGLLTLYAGLSYPDVFGSLGVFSPSIWLDEGQVQKTITRIGHKAAISDQHYYFYGGGNENRIKPDGSTVTMNTDVLQITDMLREKNHPQLEISINPEGRHGAWYWHKAFPAFYDWWQAKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR45</accession>
    <name>D7VR45_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SH3b domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994613.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13449"/>
    <dbReference type="EnsemblBacteria" id="EFK56246">
        <property type="protein sequence ID" value="EFK56246"/>
        <property type="gene ID" value="HMPREF0766_13449"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030JB5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068218_0_0_10"/>
    <dbReference type="OrthoDB" id="803246at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SH3b" evidence="1">
        <location>
            <begin position="68"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="362" mass="41853" checksum="8B5AA988C440EF59" modified="2010-10-05" version="1">MKTLLQITFSALLLSASGCGNSPKTNDKILQDTTVRDSLIQESNEEGIPIDFDKTKVLKTTTVTDRNGAELKQQPDEQSKKLGRYTYGTRLEVIEETDKWYGIRDRITRNYTENGQETETTRWEKVYVLKSKTGSMKEITLVPADLDIISLLEKNGKAEYFEKGKQLKEYLKIELIDKSLFESKKQSAVDFFLADTTKIEKKNGVIELKTPGKTVRFTDKPDAEEDMQIFKYEGQIEFLNSYLISGSYYESMDYRLIDKTSGEEKQVFGEFPYLSPDKKNIICIYANPYESTGDFELYTITDKRIKRTMSVSFKNWMPAVNPGEMFWSTDGYLYLTANHINSFWMEDGQLNTSFQYLRIKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR88</accession>
    <name>D7VR88_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lrp</name>
        <name evidence="5" type="ORF">HMPREF0766_13492</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994666.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13492"/>
    <dbReference type="EnsemblBacteria" id="EFK56289">
        <property type="protein sequence ID" value="EFK56289"/>
        <property type="gene ID" value="HMPREF0766_13492"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_0_10"/>
    <dbReference type="OrthoDB" id="1534467at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="157" mass="17529" checksum="F28A74D571066255" modified="2010-10-05" version="1">MAKVEYNLDQIDLQILRIMQDNARTNNADIARELGMAPSAILERVKKLEQKNIILQYNAKINPAAVDQKLLSFIFIKANDIIGEQGVGILLAEIPEVQEVHDIAGDDGYLIKVRTNDSSGLVDLMRNTFSKIDGIISTRTTIVLQTVKEEQKVVIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRM4</accession>
    <name>D7VRM4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994865.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13628"/>
    <dbReference type="EnsemblBacteria" id="EFK56425">
        <property type="protein sequence ID" value="EFK56425"/>
        <property type="gene ID" value="HMPREF0766_13628"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047524_0_0_10"/>
    <dbReference type="OrthoDB" id="703808at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025401">
        <property type="entry name" value="DUF4374"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14298">
        <property type="entry name" value="DUF4374"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="413" mass="44761" checksum="20A3433D128C6D6B" modified="2010-10-05" version="1">MIRTFKSLTLLSATALIGFNACSKDKRNIDTTITPGEGNKVKYVIAAHPTSAEAGTADYLLTTDDLTKGSITTKGNGIEQDGTWRYYVVNQNKFFSMLYGQGNPGAVTSYALNADGKLVKVSNFVTETVQVFAPMNNELVLFKVPRSGNENSLVYRIDAVNPGIKADKEINIVKLAGNGERAHFTWATQFGDKLLAPYMSIKGCCGDTFGTAYPDSTWVAVLSFPDLKVEKVIKDNRTSYLGGYFKNGLFVDEQGDAYGFSGATVKIGENIVSKNPSAIVRIKKGTTEFDKSYFFNFEQKTNGFKINSARYIGKGKFLVQSYAQSKSTVGVKFAIADVYAQTVTWVTGAPVNISGTTSSNYGALSEDGTKAYVGLTLDTGDSYVYIFDTATNTATQGLKVEGGTINGIHRLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRP0</accession>
    <name>D7VRP0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_13644</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0187 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994900.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13644"/>
    <dbReference type="EnsemblBacteria" id="EFK56441">
        <property type="protein sequence ID" value="EFK56441"/>
        <property type="gene ID" value="HMPREF0766_13644"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029790_4_0_10"/>
    <dbReference type="OrthoDB" id="1348684at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin/UPF0187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="UPF0187"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="PTHR33281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="295" mass="34191" checksum="8CFF0FEA68D8A054" modified="2010-10-05" version="1">MLLNKRISVWDFIKIIKFDLLYIVTFSLLIGWVSHEKYLESIVIPLPIISTMGTIVSLLLAFRTAQSYDRWWEARIVWGGIVNDSRTLIRQLIQFLPDSAQQEVALFAERQIIWNYALSESLRRIPFSNKVQSYLDKNNMHDYNIPNTILSAHSMQLKQLAEKHQITEFRQVQIDETLMRLCDSMGKCERIKNTVFPSSYSVLLHFMICVFIVMLPFCLSDNLMYAKIALTIGIPVIFIAIEKTAIMMQDPFENSPMDTPMTTLSQTIEMNILQQIGQQNVPKPTPPAPEEYYIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRT0</accession>
    <name>D7VRT0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Organic hydroperoxide resistance transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ohrR</name>
        <name evidence="2" type="ORF">HMPREF0766_13684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13684"/>
    <dbReference type="EnsemblBacteria" id="EFK56481">
        <property type="protein sequence ID" value="EFK56481"/>
        <property type="gene ID" value="HMPREF0766_13684"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_3_2_10"/>
    <dbReference type="OrthoDB" id="1626703at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="147" mass="17142" checksum="58DBBC9A6416FDEA" modified="2010-10-05" version="1">MYIFVVMEEELMLDHQVCFPIYALYREIVQQYRPLLEKLDLTYPQYLVLLVMWEHPLQTVNQIGQRLRLDSGTLTPLLKRMEQKGLIARKRSHQDERTVEISLTDAGQDLSASAKCIPGQMLNEMGITLEELMQLKTIASKILNRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRT1</accession>
    <name>D7VRT1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxiredoxin, Ohr subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ohr</name>
        <name evidence="2" type="ORF">HMPREF0766_13685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OsmC/Ohr family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995013.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13685"/>
    <dbReference type="EnsemblBacteria" id="EFK56482">
        <property type="protein sequence ID" value="EFK56482"/>
        <property type="gene ID" value="HMPREF0766_13685"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106355_2_1_10"/>
    <dbReference type="OrthoDB" id="1984062at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019953">
        <property type="entry name" value="OHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797">
        <property type="entry name" value="PTHR33797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03561">
        <property type="entry name" value="organ_hyd_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="140" mass="14690" checksum="BB025EAD27F80EB5" modified="2010-10-05" version="1">MKTLYTAVATATGGRNGHVKTDNGVLDLQVRMPKELGGANNDYTNPEQLFAAGYAACFDSALNLVISKSKIKTGETSVIAHVGIGSLAGGGFGLEAELKVNIPGIELKEAQTLVEQAHRICPYSNATRGNIEVKLTVSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRT2</accession>
    <name>D7VRT2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13686"/>
    <dbReference type="EnsemblBacteria" id="EFK56483">
        <property type="protein sequence ID" value="EFK56483"/>
        <property type="gene ID" value="HMPREF0766_13686"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3759">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129819_0_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009732">
        <property type="entry name" value="DUF1304"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38446">
        <property type="entry name" value="PTHR38446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06993">
        <property type="entry name" value="DUF1304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="122" mass="13575" checksum="D45D8E2E4BA9C9C2" modified="2010-10-05" version="1">MITIIAKILVAVVALEHLYILWMEMFAWETAGRKTFKGSLPDEMFRPTKGLAANQGLYNGFLAAGLIWSFFIEDVIWQKNITLFFLGCVIVAGIYGAISASRKIFFVQALPAILALVFVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRY5</accession>
    <name>D7VRY5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bleomycin resistance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13739</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bleomycin resistance protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995149.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13739"/>
    <dbReference type="EnsemblBacteria" id="EFK56536">
        <property type="protein sequence ID" value="EFK56536"/>
        <property type="gene ID" value="HMPREF0766_13739"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_15_4_10"/>
    <dbReference type="OrthoDB" id="1900922at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08349">
        <property type="entry name" value="BLMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000335">
        <property type="entry name" value="Bleomycin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="117" mass="13565" checksum="755D613BC12B2E39" modified="2010-10-05" version="1">MLTAIHPKLPMRDKAITLAFYTKELGFGLIGDYGDYIMIRKENIEIHFFLFRELDPLENYGQVYIRTDNIEECYQSFLDNNVSIHPNGPLEIKPWGQKEFSLLDPDHNLLTFGQGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS02</accession>
    <name>D7VS02_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995191.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13756"/>
    <dbReference type="EnsemblBacteria" id="EFK56553">
        <property type="protein sequence ID" value="EFK56553"/>
        <property type="gene ID" value="HMPREF0766_13756"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033K1A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1916309_0_0_10"/>
    <dbReference type="OrthoDB" id="2064683at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="133" mass="15805" checksum="D6363023E8E1D6FB" modified="2010-10-05" version="1">MKKIEEAVIDYFEFIIGYKILIDQKGIEESSFINKGKGELGLYKYHYHGAGCRLEKEGVICEYDYLPTNDYPIKFSSWKLFEFMETNPKWKAQDYNLDDVHHSLMTLVEKKKLFLLDLNGVMFPIFQIKDIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS11</accession>
    <name>D7VS11_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13765"/>
    <dbReference type="EnsemblBacteria" id="EFK56562">
        <property type="protein sequence ID" value="EFK56562"/>
        <property type="gene ID" value="HMPREF0766_13765"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006833_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1157" mass="132466" checksum="FBB5AC75796E5FF1" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS15</accession>
    <name>D7VS15_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995218.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13769"/>
    <dbReference type="EnsemblBacteria" id="EFK56566">
        <property type="protein sequence ID" value="EFK56566"/>
        <property type="gene ID" value="HMPREF0766_13769"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031YYQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1712131_0_0_10"/>
    <dbReference type="OrthoDB" id="2054680at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107231" evidence="2">
        <location>
            <begin position="21"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="153" mass="17617" checksum="C995CE9B815E8D37" modified="2010-10-05" version="1">MKKMLLLVGLMSGLTFATYAQEVQSKPVKRTDRGEKMINKTPEEMATLQTERLDKELKFTEAQKKQVYAIQLKNAQKQKEVMSDNKAGREAFREGMKQNQEELNKVLTPEQQNILKEKRAQRGERMKGKRKMDGERGSRKAEKTAPAEDKTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS25</accession>
    <name>D7VS25_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Riboflavin biosynthesis protein RibD C-terminal domain protein</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">folA</name>
        <name evidence="2" type="ORF">HMPREF0766_13779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13779"/>
    <dbReference type="EnsemblBacteria" id="EFK56576">
        <property type="protein sequence ID" value="EFK56576"/>
        <property type="gene ID" value="HMPREF0766_13779"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_1_3_10"/>
    <dbReference type="OrthoDB" id="1306955at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="184" mass="20734" checksum="4D9E1F7A709A36B8" modified="2010-10-05" version="1">MRKLIYGINVSLDGCCDHTKFSGGDDIHDYFRELMLDVDLIIYGRKTYELMVPFWPQVAHAQSMNKSANAFASTFASIKRLLVSRTINQIDDEYTTLIKDNLQEEILKLKQQPGKSISTGGIELPARLIELGLVDEFHILVHPVIVGEGRRLFTEMHLPENLGLNLTATKTLPSGCIALRYEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS39</accession>
    <name>D7VS39_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995281.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13793"/>
    <dbReference type="EnsemblBacteria" id="EFK56590">
        <property type="protein sequence ID" value="EFK56590"/>
        <property type="gene ID" value="HMPREF0766_13793"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2453088_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="89" mass="9884" checksum="988EBCC9F8F3F362" modified="2010-10-05" version="1">MLAFFYSVQYTHTHHHAAHAQGNSSPAKDSATECAICHIIHTDRTILPLSPELTLSVPEHPVNRLVQDKLAFRIPKGFDALKSNKDPPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS50</accession>
    <name>D7VS50_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13804"/>
    <dbReference type="EnsemblBacteria" id="EFK56601">
        <property type="protein sequence ID" value="EFK56601"/>
        <property type="gene ID" value="HMPREF0766_13804"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3103966_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="51" mass="6393" checksum="C44B18ADCD48FC9F" modified="2010-10-05" version="1">MFSKKEIAERRKQYEDYKRIANKCIDELILLDKNNAYDYEKLREKYKYPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS72</accession>
    <name>D7VS72_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase</fullName>
            <ecNumber evidence="3">4.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybaK</name>
        <name evidence="5" type="ORF">HMPREF0766_13826</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.-.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995363.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13826"/>
    <dbReference type="EnsemblBacteria" id="EFK56623">
        <property type="protein sequence ID" value="EFK56623"/>
        <property type="gene ID" value="HMPREF0766_13826"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094875_3_0_10"/>
    <dbReference type="OrthoDB" id="1503081at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00002">
        <property type="entry name" value="YbaK_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004369">
        <property type="entry name" value="Prolyl-tRNA_editing_YbaK/EbsC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006181">
        <property type="entry name" value="EbsC_YbaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00011">
        <property type="entry name" value="YbaK_EbsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="4">
        <location>
            <begin position="34"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="156" mass="17061" checksum="DDB11B74249B6158" modified="2010-10-05" version="1">MSNKTNAVRMLDQLKVNYELREYDVDEDDLSAGHVAESLGLDPKSLYKTLVLKGNTGGYLVAVIPGDTQLDLKKIAKASGNKNCEMIPVKNIQTLTGYIRGGCSPIGMKKAFPTYIEQSVREQTSISISAGKRGLQIILSPQDLVKVTNARYAELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSE8</accession>
    <name>D7VSE8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_13902</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995537.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13902"/>
    <dbReference type="EnsemblBacteria" id="EFK56699">
        <property type="protein sequence ID" value="EFK56699"/>
        <property type="gene ID" value="HMPREF0766_13902"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128738_4_1_10"/>
    <dbReference type="OrthoDB" id="1606159at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK56699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="152" mass="17432" checksum="53E4159BC3F4540C" modified="2010-10-05" version="1">MKLLILLFTAFFIALLGSKFMYGFWDFVFAGNLGMSVFIIFTGLSHFRFQKGMAMMMPDYIPAKMFFVYLTGILEIAAGIGLMIPRLRALTALLLIIFLVVVFIANVNSSRKMINIFKADYTGPGMNYLYAQRLPMQLILIGWTWYFGLYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSK3</accession>
    <name>D7VSK3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13957"/>
    <dbReference type="EnsemblBacteria" id="EFK56754">
        <property type="protein sequence ID" value="EFK56754"/>
        <property type="gene ID" value="HMPREF0766_13957"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3296709_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="40" mass="4830" checksum="7184616919765D18" modified="2010-10-05" version="1">MLKSAYITNFLRKENERKVLNQRYLSISKKKRAVFDKNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSK5</accession>
    <name>D7VSK5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LuxE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995618.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13959"/>
    <dbReference type="EnsemblBacteria" id="EFK56756">
        <property type="protein sequence ID" value="EFK56756"/>
        <property type="gene ID" value="HMPREF0766_13959"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043257_0_0_10"/>
    <dbReference type="OrthoDB" id="839891at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047474">
        <property type="term" value="F:long-chain fatty acid luciferin component ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008218">
        <property type="term" value="P:bioluminescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007534">
        <property type="entry name" value="LuxE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04443">
        <property type="entry name" value="LuxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LuxE" evidence="1">
        <location>
            <begin position="10"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="325" mass="37186" checksum="E5D13FAB3B8D11FE" modified="2010-10-05" version="1">MDTQQIFEIQSDKQFNDNCLSIFRYQYDHCQTYKQYVDYLHIDTKDIAHYTQIPFLPIELFKSQEIITSGSVPQVTFSSSGTTGMITSKHLVVDAKLYESSFRKAFKQFYGDVRDIAVLALLPSYLERSGSSLIYMVDDLIKSSEQPESGYFLYNHADLFTVLQKLKQKNTKTILFGVTYALLDFVETYEIDFPGLIIMETGGMKGKRKEMIREEVHDLLREGFNVPAIHSEYGMTELLSQGYSYGKGIFQHPNWMKILIRDTNDPLTLIDNSRTGAINVIDLANIYSCSFIATQDLGKIYPDGSFEVLGRFDQSDIRGCNLLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VST0</accession>
    <name>D7VST0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-54 interaction domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_14034</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995777.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14034"/>
    <dbReference type="EnsemblBacteria" id="EFK56831">
        <property type="protein sequence ID" value="EFK56831"/>
        <property type="gene ID" value="HMPREF0766_14034"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_10"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="144"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK56831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="449" mass="51349" checksum="3C2F015500EF14A2" modified="2010-10-05" version="1">MKKVEASVLVVDDQEEVLIASRMILKRYFETVNVLSDPGQLLDKIRSYAVDVVLLDMNYRLGYENGREGIYRLKEVQEHFPQVRIILMTSYANVETAVEGIKLGAIDYMLKPWDNDKLIEIVKSAVQQIRKAKKTAVPSAPVFFQGSSAEIQRVYQMGERVAKTDATVLIQGENGTGKYVLAEYIHKHSSRRDRPFIHVDLGSLNENLFESELFGYVRGAFTDARADTAGRFEQADGGTIFLDEIGNIPLHLQSKLLQVIQSKGVTRLGESKVRQLDVRIITATNVDLESAVKEKTFREDLYYRIHTVSLYLPALRERRDDIADMLQFFMKHMTEKYDMEMLHIGDSTLRQLEQYEWRGNIRELQNRIERAVILADQPELTLEHMGFEGVLALVKSKEETTISDVERNLIIDSLQKYAGNISKAAHELGVSRAALYRKLEKYSIPNPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTC0</accession>
    <name>D7VTC0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UbiC transcription regulator-associated domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996222.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14224"/>
    <dbReference type="EnsemblBacteria" id="EFK57021">
        <property type="protein sequence ID" value="EFK57021"/>
        <property type="gene ID" value="HMPREF0766_14224"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_2_3_10"/>
    <dbReference type="OrthoDB" id="1775418at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="244" mass="28706" checksum="BAED12318FE4ACA6" modified="2010-10-05" version="1">MNLQIDHKSPVPLHIQAEMLLRELIKDPEYIDGKLLPNEVELARRLAISRTTLRLAINKLVYEELLVRKKGVGTKVVTSKFSSKSKNWLSFSQEMKNRGIEVKNFELHVSWVVPEKSIMHFFDIKEDQKILKLERLRGKKDDPFVYFVSYFHPRIGLTGDEDFKRPLYEILEQDHHIIADLSQEEIDAKAANKFIADKLEINQGDPILSRKRFVYDQSGRPIEYNLGYYRAESFTYTVESRRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTI4</accession>
    <name>D7VTI4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">OmpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_14288</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996387.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14288"/>
    <dbReference type="EnsemblBacteria" id="EFK57085">
        <property type="protein sequence ID" value="EFK57085"/>
        <property type="gene ID" value="HMPREF0766_14288"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047813_0_0_10"/>
    <dbReference type="OrthoDB" id="2018797at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009282">
        <property type="entry name" value="DUF937"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06078">
        <property type="entry name" value="DUF937"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="5">
        <location>
            <begin position="330"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK57085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="446" mass="47881" checksum="020AFBFB80FC64CE" modified="2010-10-05" version="1">MENNLLNNAKAFFNEDTLSKLSGKVGVDSAQLKQGTDLVIPTLFLGLQRENENGLNTILEQAKSHFGNFDFQQWFNSDGSAPVGGAAEDVNSQHPEHQHILQSIFGGKLDTVVSAISGFIGIKSDTIQKLLSSALPAVFASLTNNGTNWNAASISNLLNENKSNFAAALPAGLGLGAFGSLFADSDIQSPAVETRIPPADIPVVEPPVLTVPPVNPEPAIHTREAVREVKKSSGLWWILIPLVLVALWFLFGKSCAGNGAGTSDSTSNGRDTSSMTNPADSLGAADGLSNRESVILKLPDGQELRAYPRGIEDNLIKFLQSDYKALPDDTLKNKWFDFDNLNFETGTAKILPASRDQLLNLAAILKVFPDAKVKIGGYTDKTGDESFNKKLSLDRANAVKVFLDEQGLGAQVAGTEGYGSEIARYPADAPESDRIKDRRVSVSVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTM3</accession>
    <name>D7VTM3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001635.1">
        <property type="nucleotide sequence ID" value="NZ_GL379777.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14343"/>
    <dbReference type="EnsemblBacteria" id="EFK55782">
        <property type="protein sequence ID" value="EFK55782"/>
        <property type="gene ID" value="HMPREF0766_14343"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_3_2_10"/>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="109" mass="12374" checksum="C9CED47A101F883A" modified="2010-10-05" version="1">MGLTKTDIYKDDQNKLASLLKILGHPARIAILQYIIDQKSCICNDLVEELGLAQATISQHLKELKSIGIIQGSIDGKSVCYCIDEKIWKQFQDEFNIFFNQDVKVNHCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTW9</accession>
    <name>D7VTW9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpmH</name>
        <name evidence="7" type="ORF">HMPREF0766_14439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14439"/>
    <dbReference type="EnsemblBacteria" id="EFK55748">
        <property type="protein sequence ID" value="EFK55748"/>
        <property type="gene ID" value="HMPREF0766_14439"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129938_2_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_L34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK55748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="52" mass="6284" checksum="8E0DF1012CA2CB83" modified="2010-10-05" version="1">MKRTFQPSQRKRRNKHGFRERMSTANGRRVLASRRAKGRKRLTVSDEYRHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VU01</accession>
    <name>D7VU01_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Divergent AAA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000015">
        <property type="protein sequence ID" value="EFK55696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001784.1">
        <property type="nucleotide sequence ID" value="NZ_GL379777.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14471"/>
    <dbReference type="EnsemblBacteria" id="EFK55696">
        <property type="protein sequence ID" value="EFK55696"/>
        <property type="gene ID" value="HMPREF0766_14471"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2865">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024970_3_0_10"/>
    <dbReference type="OrthoDB" id="912543at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025831">
        <property type="entry name" value="RecG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038475">
        <property type="entry name" value="RecG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007421">
        <property type="entry name" value="Schlafen_AlbA_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038461">
        <property type="entry name" value="Schlafen_AlbA_2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04326">
        <property type="entry name" value="AlbA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13749">
        <property type="entry name" value="HATPase_c_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlbA_2" evidence="1">
        <location>
            <begin position="7"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_4" evidence="2">
        <location>
            <begin position="283"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK55696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="451" mass="51625" checksum="2CB05FE6F120476D" modified="2010-10-05" version="1">MSLHTKEHQNIEWKESWHNDYFKWICGFANAQGGTLFIGKDDKGKLKHVANTKKLLEDIPNQVRDLLGLMVDVNLHTENKADYLEIIVEPYPFPISLRGKYYYRSGSTLQELKGTALTKFLLQRQGKKWDGVPVPNITVDDLKNDTFDFFRKKAVKSKRLEPEDIEGTNQQLLENLQLYLEDEKMIKRAGILLFHPKPKKFVTGAFIKIGFFEDDDDLKFQDEVKGNLLEQAEKALDLLKTKYTQAIISYQNGSREETFIFPEEAIREALYNAIAHKDYSSGIPIQISVYPHKMIFWNEGQLPENWTVEKLTQKHPSKPYNPDIANTFFRAGYIESWGRGTIKMINACKAHKIAPPIFSNIPPDFQVELVKYTDKGLKGSGLKEELRKIILYVQEKGRISNSEVQSICDVSKATATRYLGELEGEWIEKIGSTGVGTAYVFKGLSKGSKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VG99</accession>
    <name>D7VG99_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001857.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10018"/>
    <dbReference type="EnsemblBacteria" id="EFK60074">
        <property type="protein sequence ID" value="EFK60074"/>
        <property type="gene ID" value="HMPREF0766_10018"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50336UC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1276947_0_0_10"/>
    <dbReference type="OrthoDB" id="1469331at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025250">
        <property type="entry name" value="DUF4199"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13858">
        <property type="entry name" value="DUF4199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK60074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="216" mass="23954" checksum="3F23AEB2758BE2FE" modified="2010-10-05" version="1">MTDQLSLQEPDGKKQSITYGLYLGVIALVLGIVTMYISKSTTSLMVLFGVSAVLNLVIFLVVAVLFSISIRKSIGGYWSFSEALKKIFIMFAVAALLSSLGSFAFTKFVEPTIQEEVINNTSNLTIEMLEKTGAGDEQIDETIAKLDEQKAEISKMSFWQFFKGIGVTMIFYFVLALILAAILKKEKPFFQQHPNVDPNTDPNANYGAWPDQNNPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGC5</accession>
    <name>D7VGC5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0766_10044</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001929.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10044"/>
    <dbReference type="EnsemblBacteria" id="EFK60100">
        <property type="protein sequence ID" value="EFK60100"/>
        <property type="gene ID" value="HMPREF0766_10044"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_10"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="36"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="330"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="362"/>
            <end position="369"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK60100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="578" mass="64611" checksum="09871DCF2539FA3D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGL3</accession>
    <name>D7VGL3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">bfmBB</name>
        <name evidence="8" type="ORF">HMPREF0766_10132</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996664.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10132"/>
    <dbReference type="EnsemblBacteria" id="EFK59215">
        <property type="protein sequence ID" value="EFK59215"/>
        <property type="gene ID" value="HMPREF0766_10132"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_1_10"/>
    <dbReference type="OrthoDB" id="1626282at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="148"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="462" mass="50027" checksum="A4497E59BCA3F1DC" modified="2010-10-05" version="1">MALYNLTLPKMGESVSEATVTKWLKEPGDRISEDEAVVEVATDKVDSDVPSPVSGILKEKKISDGEIAQVGQIIAVIEIEGEGEGEETTVTSAEVNEAEANMINPTPVKDEDIIVQEIQLPDLEIPGVDQLPASPAAHKEAIHNNIRFYSPLVRNIAQEEGLSQQELDSIPGTASDGRVTKQDVLNYLQQRRQTGQSNTTPAPAGTSAAASTAPDSSPTKAIGITAAGDEIIEMDRMRKLIADHMVKSVQTSPHVCSFVEADVTNMVNWRNKIKDSYKKREGENITFTPLFIEAISKALKDFPMVNVSIDGTNIIKRKNINIGMAAALPTGNLIVPVIKNADQLSLVGLSKTVNDLAVRSRANKLKPDDTQGGTFTFTNIGAFGNIMGTPIINQPQAAILAVGTITKKPAVIETEFGDMIGIRHIMYLSMSYDHRVIDGALGGTFLKRVADYLEQWDTNRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGR3</accession>
    <name>D7VGR3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CheR methyltransferase, SAM binding domain protein</fullName>
            <ecNumber evidence="2">2.1.1.80</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cheR</name>
        <name evidence="2" type="ORF">HMPREF0766_10182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996808.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10182"/>
    <dbReference type="EnsemblBacteria" id="EFK59265">
        <property type="protein sequence ID" value="EFK59265"/>
        <property type="gene ID" value="HMPREF0766_10182"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025854_1_0_10"/>
    <dbReference type="OrthoDB" id="1378151at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008983">
        <property type="term" value="F:protein-glutamate O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="269" mass="31030" checksum="A2DCF95E2D7C5D86" modified="2010-10-05" version="1">MISFSELEELIELVKNVNGMDLSGYSRASLKRRVTRLMEIDRMDLVALKTALVNTPGYFNHFIIELTVNVTEMFRDPFFYKAMREDVFPYLASFPRIKSWSAGCSSGEEVYSLAIVLKEAGLYDRSFIYGTDINNIVLEQAKKGIYSLQKIKDYSDNFLKSGTVHSLSDYYTAMYDAASINNDLKKNILFSSHNLVSDGVFNEFQLITCRNVLIYFDLELQQNVIRLFYESLCLFGFLCLGSKETLHHQEIASKFKLINKKYNIYQKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGU4</accession>
    <name>D7VGU4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease, YjgP/YjgQ family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_10213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996890.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10213"/>
    <dbReference type="EnsemblBacteria" id="EFK59296">
        <property type="protein sequence ID" value="EFK59296"/>
        <property type="gene ID" value="HMPREF0766_10213"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028799_3_1_10"/>
    <dbReference type="OrthoDB" id="1558251at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="359" mass="41384" checksum="013CCA9F1557F8EE" modified="2010-10-05" version="1">MKIIDWYIIKKYLSTFVFTMAIFTVVMVIFDVSEKLDNFLQYKAPISKIVFQYYAGFIPFYLNFLSPLINFIAVIFFTSKMADQTEIVPILSGGMSFNRMLRPYMIAASLIFAVTFVFNIYIIPRTNKMKVSFENVYVKPDKAGGSISATHMQIDSNTYVYIDNFDTRQKIGYNFVLEKFDADRLKEKMIADRIRWDSVATKWKIENYTNRVINGLNERMEKADQKDTTLDMKPSDFEKYDNMFTAMNTDELSKRIDKEETRGTGMMTELLLEKYKRYIYPFSAFILTLMGVSLSSKKVRGGIGLSLGLGIALSFVYIVLIQFSTMFSLKGGLPPLIAVMIPNLIFLSLGLYLMYKAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGW5</accession>
    <name>D7VGW5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclic nucleotide-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996947.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10234"/>
    <dbReference type="EnsemblBacteria" id="EFK59317">
        <property type="protein sequence ID" value="EFK59317"/>
        <property type="gene ID" value="HMPREF0766_10234"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_7_0_10"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH crp-type" evidence="2">
        <location>
            <begin position="151"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="209" mass="23858" checksum="2EFA9E5178D12494" modified="2010-10-05" version="1">MYTAALQVAYGTVFEPRLINEIEEVARFLSFKKADVLIDAGQYIKVMPLLVDGAIRIMREDPWEGELLLYFLEKGDACAMTLACCLGDKKSEIKAVAETDALVAMIPVSKMEEWLAKYSSWRNFVFTSYNKRMEEMLGAIDQLAFHKMDVRILHYLEEIAKINNTRSINKSHQEIAAALNTSRVVVSRILKVYENEGKVRLNRSTIDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH42</accession>
    <name>D7VH42_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5017 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997145.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10311"/>
    <dbReference type="EnsemblBacteria" id="EFK59394">
        <property type="protein sequence ID" value="EFK59394"/>
        <property type="gene ID" value="HMPREF0766_10311"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066814_0_0_10"/>
    <dbReference type="OrthoDB" id="1733299at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032185">
        <property type="entry name" value="DUF5017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16409">
        <property type="entry name" value="DUF5017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5017" evidence="1">
        <location>
            <begin position="18"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="350" mass="38554" checksum="E4B9587F76EAED74" modified="2010-10-05" version="1">MKSIKKIMGFLSVLLLISCEKNISPNPISFDVDIFNNSDIKTTKFKVNDTLNFKFSGNPDRITFYSGETGRMYINRNKTTDPSPNNTLRFYTNRGNAGTDKLQLLYTTDSILYTQFNNKDSIAIPLAKWKDISDRVTWATGNSNMQSGDISLNTEASTGSGKIWLAFKYTAPAGVGQGTWTVGNIDLRHYVGDTYYTLLTSAIVIPTAFPSYTVSPGWGTVNVTNPLLKWTLTGGSSGNTSIGQSLSSNFSTQSFTIRGNTNSTTSRQTESWIISGPVDLKRVLPDYGVSVKNQTENAENVSKGFYASPKANFTYSFTKPGTYEMVFYSQNDTGFGEISTTKTIKVEIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH63</accession>
    <name>D7VH63_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10332</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997186.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10332"/>
    <dbReference type="EnsemblBacteria" id="EFK59415">
        <property type="protein sequence ID" value="EFK59415"/>
        <property type="gene ID" value="HMPREF0766_10332"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032XY4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126587_0_0_10"/>
    <dbReference type="OrthoDB" id="1802710at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106893" evidence="3">
        <location>
            <begin position="23"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="183" mass="21205" checksum="8CE162FC879F2C5F" modified="2010-10-05" version="1">MKIKHLLFYVALLLAYVPAVHAQQPSSDTLSYEIQRKKVNELLHNRSVKFGEYDVSLQKKTGIFGLFKSKGDMQKSIDILKEIVTTDNNIFIETKRLLDMKDFEREKFQKLATEYDGQVTAYMNTINKLQNENEALKKQMDTLENSDHSGNVLLYLAIAIICGLIFFIYKLYKQVQQQKVTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHE1</accession>
    <name>D7VHE1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate dehydrogenase or fumarate reductase, flavoprotein subunit</fullName>
            <ecNumber evidence="6">1.3.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sdhA</name>
        <name evidence="6" type="ORF">HMPREF0766_10410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.1" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997369.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10410"/>
    <dbReference type="EnsemblBacteria" id="EFK59493">
        <property type="protein sequence ID" value="EFK59493"/>
        <property type="gene ID" value="HMPREF0766_10410"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_7_0_10"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011280">
        <property type="entry name" value="Succ_DH/Fum_Rdt_flav_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF53">
        <property type="entry name" value="PTHR11632:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01811">
        <property type="entry name" value="sdhA_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="35"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="5">
        <location>
            <begin position="508"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK59493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="643" mass="71430" checksum="5048D2A83618C71F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHH1</accession>
    <name>D7VHH1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">map</name>
        <name evidence="5" type="ORF">HMPREF0766_10440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997458.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10440"/>
    <dbReference type="EnsemblBacteria" id="EFK59523">
        <property type="protein sequence ID" value="EFK59523"/>
        <property type="gene ID" value="HMPREF0766_10440"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_0_1_10"/>
    <dbReference type="OrthoDB" id="1285136at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="13"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="260" mass="28316" checksum="12AD5D4D2347376E" modified="2010-10-05" version="1">MSKVYYKSEEEIEQVRKSADVLSQLLGEVAKVIKPGITTLSLDKLAYDFIHDNGGTPAFLNYHGFPYSLCISVNDQIVHGFPSEYVIKDGDLVSVDGGVNLNGFISDSAYTFGVGEISAEAQQLLDVTKESLNRGVAQAVAGKRVGDISSAIQEYVAPYNYGIVKELVGHGVGFHLHEKPEVPNYGKRGSGPKLEQGLVICIEPMINAGKAGVKFWDDGWTVSTVDGKLSAHFEQMVAIRKGEPDVLLTFEHVEKVLNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHK5</accession>
    <name>D7VHK5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribonuclease III</fullName>
            <shortName evidence="6">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rnc</name>
        <name evidence="10" type="ORF">HMPREF0766_10474</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997521.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10474"/>
    <dbReference type="EnsemblBacteria" id="EFK59557">
        <property type="protein sequence ID" value="EFK59557"/>
        <property type="gene ID" value="HMPREF0766_10474"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0571">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000907_1_0_10"/>
    <dbReference type="OrthoDB" id="1890943at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="8">
        <location>
            <begin position="157"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK59557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="229" mass="25970" checksum="DC0870C5FBA7D3D4" modified="2010-10-05" version="1">MRKLKNLLGFVPENIRLYQMAFRHKSVATAIKEGAKNSNERLEFLGDAILGSVVAELLFKKYPYKDEGFLTEMRSKIVSRANLNQLSRKLGLNELIQYDARMISFPNKQGSLLGDAFEALVGAVYLDKGYTFTKSFLLNRIIKTHVDIQLLEVTETNFKSRLIEWCQHLGKDVQFLPTANPEGESSKMFSIEAIVEGEVCGIGRDFNKKSAEKLAAEKACEYLKIFETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHU0</accession>
    <name>D7VHU0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK59642">
        <property type="protein sequence ID" value="EFK59642"/>
        <property type="gene ID" value="HMPREF0766_10559"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3239801_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="43" mass="5107" checksum="A3D7F6554AE00BF1" modified="2010-10-05" version="1">MANEDRQDVIIFYSLPDMQTEQNWERIDKNIIFKGSISFVNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI77</accession>
    <name>D7VI77_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, group 1 family protein</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998023.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10696"/>
    <dbReference type="EnsemblBacteria" id="EFK59779">
        <property type="protein sequence ID" value="EFK59779"/>
        <property type="gene ID" value="HMPREF0766_10696"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058587_0_0_10"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="201"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="386" mass="44003" checksum="BE2A8F45E45EEFAD" modified="2010-10-05" version="1">MNLLFITDARFIKGKGGKYYSGEASFSNTLWERYLKSFDEVQVIGRVFENPLFSIEGHIVNNVKILPVIPFESVFSFVIQIREIRRLIKSYIVDFEGAIIIRGAGSLGYLAVKICKELDIPFALELVGDPHEVYAPGVIKHPLRPFLRYLFTQYQKKAALSCSAILYVTKNTLQRRYPVKESVFSTYASDVFISEISFETKVLVPNKKIELISIGSLDQMYKAPDIALKAVKLFKEKYNNNIHLTWLGKGHFKNDMEIMAQELGLRHNVSFMGSVSSETVKKLLAESDIFLLVSRTEGLPRAIIEAMSFGLPCIGTNIGGIPELINKDLLVDVNNINQIVDKLYLLSQSFDYYSCMSSYSLEKAKEFSFSELEERRKLFFEEIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIB1</accession>
    <name>D7VIB1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mg chelatase-like protein</fullName>
            <ecNumber evidence="3">6.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">comM</name>
        <name evidence="3" type="ORF">HMPREF0766_10730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998092.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10730"/>
    <dbReference type="EnsemblBacteria" id="EFK59813">
        <property type="protein sequence ID" value="EFK59813"/>
        <property type="gene ID" value="HMPREF0766_10730"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026145_1_0_10"/>
    <dbReference type="OrthoDB" id="581802at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016851">
        <property type="term" value="F:magnesium chelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032508">
        <property type="term" value="P:DNA duplex unwinding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00368">
        <property type="entry name" value="TIGR00368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="213"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="512" mass="56317" checksum="371FC79714584709" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D7VID5</accession>
    <name>D7VID5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK59837">
        <property type="protein sequence ID" value="EFK59837"/>
        <property type="gene ID" value="HMPREF0766_10754"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50337H3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1804945_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="141" mass="15969" checksum="23A42C3D8CDFAD70" modified="2010-10-05" version="1">MLIIPGLSSAQEADTVPELIDDIQVDVKNVSVDAKTKILTLDLFLISYQKNPREFKLNTFATQVLDTKGQTYMYSTMQMGKVLIKLSDRQNYLHYFMEDEVPVAFKITVDNWTKGNKAKAVKLVFEDSAEAGKFIEKAVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIF5</accession>
    <name>D7VIF5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998176.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10774"/>
    <dbReference type="EnsemblBacteria" id="EFK59857">
        <property type="protein sequence ID" value="EFK59857"/>
        <property type="gene ID" value="HMPREF0766_10774"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_771237_0_0_10"/>
    <dbReference type="OrthoDB" id="61917at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="372" mass="42936" checksum="C4A744947AC6C822" modified="2010-10-05" version="1">MNKPYLKVMDEVENPASADLIEDLTTELADKLPSFDLSHIKRLTNHVGILQHATYITPNYHHGYCIDDNARALILALMAFEKEPSDEHNQLISTYLAYIKYMQLDNGKFRNFLSFSHVFLDDEGTEDAMGRTIWALGYLLKCNVNPSFHRTGRELFDRVVPHVYSLRSPRAVSYSILGLIHISERSPEDEGIKELIHHLAQYIAEEYRQNSTSEWSWYEKIISYDNAILPLSLLRASLVLEDESLKLTAMESFHFLDSILFRENYLCIIGNEFWYREGGNPSMYGQQPIEVTSLVLLYEEMYNITLEKIYKQRMISSFLWFFGKNKQGLQLYDASSKGCCDGLDSHGVNLNQGAESTICFWIAYLNISRLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIF6</accession>
    <name>D7VIF6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 130 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998178.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10775"/>
    <dbReference type="EnsemblBacteria" id="EFK59858">
        <property type="protein sequence ID" value="EFK59858"/>
        <property type="gene ID" value="HMPREF0766_10775"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_640768_0_0_10"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="486" mass="56230" checksum="653440E69BA4C153" modified="2010-10-05" version="1">MTLNVVRKNIFFKPDSRRVLARYFNLSVERSIKIVQRVLKMSKQEKADTLNQVLRNFSKRHRSVVSILEKNYKRTETILREMNIKDEDVTYKEKLLIGAYFTMEYSIEAAAFFNPSVVESPDQTQLKEGEKRIILSFRATGEGHVSSIVFRSAIIDKDLNIHLDEVGTLLEKPKQFKSHRYQKEDFIDKLLQMHDPEEDVLTVIRAKLTDSFTYEELRRFVREMQQENELTPDSQTLMSQIMWLASSHYEMTYSLDTSISERVIFPISDTEKNGIEDARFVRFRGEKNQQTYYATYTAYDGFTILPKLMSTKDFIHFKVQPINGKIANKGAALFPRKIKGKYAMLCRVDGENNYIAFSEDINIWQQDITLLKEPEYPWELVQLGNCGSPIETEKGWLVLTHGVGPMREYTLGAILLDLEDPTKIIGKLNEPLLYPNADEREGYVPNVVYSCGQIIHNGHLIIPYAMSDYASTYASVELKELLDALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIG4</accession>
    <name>D7VIG4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Topoisom_I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998195.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10783"/>
    <dbReference type="EnsemblBacteria" id="EFK59866">
        <property type="protein sequence ID" value="EFK59866"/>
        <property type="gene ID" value="HMPREF0766_10783"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046978_1_1_10"/>
    <dbReference type="OrthoDB" id="812517at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.66.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035447">
        <property type="entry name" value="DNA_topo_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55869">
        <property type="entry name" value="SSF55869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Topoisom_I" evidence="2">
        <location>
            <begin position="96"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="349" mass="40342" checksum="53486A805C794D35" modified="2010-10-05" version="1">MKTSAAMPHAALDIKLRYVSDQQPGYTRKEKNGKFLYFSDKGKITDKKVLDRIRALVLPPAWQQVWICAKANGHIQATGIDARGRKQYRYHNDWSAFRNLKKFDRLEGFARKLKLLRAQLKKDLRRKKLTKEKVCAIAVNIMSLTYIRAGNKAYEAEYGSFGLTTLKNKHIKIQSNKVFFKFKGKKGVVQQIYLKEPKLVKMLKNIKDIPGQELFQYYNKNGEIVRLDSGDINSYLKEAMKDEYTCKDFRTWAGCTLALIVMAEMPVAETETERKKNLVRIIDEVASKLGNTRTVTRNYYIHPELQNQYLDQRLAPVLNRIAKKSKDKLSVTEIAEKSFLKFLLSLTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VII2</accession>
    <name>D7VII2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2147 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998228.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10801"/>
    <dbReference type="EnsemblBacteria" id="EFK59884">
        <property type="protein sequence ID" value="EFK59884"/>
        <property type="gene ID" value="HMPREF0766_10801"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4731">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108869_2_1_10"/>
    <dbReference type="OrthoDB" id="1848240at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019223">
        <property type="entry name" value="DUF2147"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09917">
        <property type="entry name" value="DUF2147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107530" description="DUF2147 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2147" evidence="2">
        <location>
            <begin position="26"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="142" mass="16185" checksum="CE5C23E1CD5CF02F" modified="2010-10-05" version="1">MKKLMLSLMVLFVTVALFAQTDPVIGKWQNPSGEARVEIYKKGDKFYGKIYWLKTPNDESGHPKKDVKNPDDKLKSRPVLGMENLTNFEKVKDNLYENGKVYDPKSGKTYSCKMTLKGDKLDIRGYVGVSLIGRTDTFTRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIK8</accession>
    <name>D7VIK8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998278.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10827"/>
    <dbReference type="EnsemblBacteria" id="EFK59910">
        <property type="protein sequence ID" value="EFK59910"/>
        <property type="gene ID" value="HMPREF0766_10827"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_1_1_10"/>
    <dbReference type="OrthoDB" id="1439085at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="211"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="586" mass="65452" checksum="FBB23A2463067CD2" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIS2</accession>
    <name>D7VIS2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">recO</name>
        <name evidence="6" type="ORF">HMPREF0766_10891</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RecO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998415.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10891"/>
    <dbReference type="EnsemblBacteria" id="EFK59974">
        <property type="protein sequence ID" value="EFK59974"/>
        <property type="gene ID" value="HMPREF0766_10891"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087596_1_0_10"/>
    <dbReference type="OrthoDB" id="1758685at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2 4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3 4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_rep/recomb_RecO_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK59974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="240" mass="27425" checksum="6A851A15AA02C090" modified="2010-10-05" version="1">MLHKTKGIALKLTNYSESSVVVQVYTESFGLQSYLVNGAKKPKAKIKANLFQPLHLLELIVYHKDNNNLQRISEAHQTPPLLDLPYNIIKSSIAIFLNEVLYKSLKQQQHDGFLFNFIFQSIRYLDETDHSLANFHLTFLIKLSMFLGFLPNVGTKVLPYFDLREGNFSSSLPAHSDVLQPPHTEIFHQLIGSTYASAAALKINKEERALLLSKILDFYNIHVANFGEINSVYILEEIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIY0</accession>
    <name>D7VIY0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2007 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10949"/>
    <dbReference type="EnsemblBacteria" id="EFK60032">
        <property type="protein sequence ID" value="EFK60032"/>
        <property type="gene ID" value="HMPREF0766_10949"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3157935_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018551">
        <property type="entry name" value="DUF2007"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09413">
        <property type="entry name" value="DUF2007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2007" evidence="1">
        <location>
            <begin position="2"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="48" mass="5438" checksum="D3D47313BF0D2F0E" modified="2010-10-05" version="1">MLLENEVNAVVLNKQDSSYLFGKIELYVNVNDVDKANALIDELNPEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ07</accession>
    <name>D7VJ07_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002085.1">
        <property type="nucleotide sequence ID" value="NZ_GL379779.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10976"/>
    <dbReference type="EnsemblBacteria" id="EFK59142">
        <property type="protein sequence ID" value="EFK59142"/>
        <property type="gene ID" value="HMPREF0766_10976"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_5_1_10"/>
    <dbReference type="OrthoDB" id="2057904at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="122" mass="14008" checksum="6BA05CBD123C55EE" modified="2010-10-05" version="1">MTAIKESSTIQENKRYALSQCPVTYVMEKIGGYWKPIIIYHLHTGDKRYSELKRAIPAITEKVLIQHLKQLEADQLIIREAKPVVPPFVTYKLSAAGKGLFPVIDAMANWAFQDMEKVFDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ67</accession>
    <name>D7VJ67_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Protein-beta-aspartate methyltransferase</fullName>
            <shortName evidence="2">PIMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">pcm</name>
        <name evidence="3" type="ORF">HMPREF0766_11036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000393.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11036"/>
    <dbReference type="EnsemblBacteria" id="EFK58920">
        <property type="protein sequence ID" value="EFK58920"/>
        <property type="gene ID" value="HMPREF0766_11036"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055432_2_0_10"/>
    <dbReference type="OrthoDB" id="1948290at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00090">
        <property type="entry name" value="PIMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="218" mass="24777" checksum="C30C2D2E1CB424B2" modified="2010-10-05" version="1">MAYKFVDNYRERGARKQLVKHLEKRGIEDKQVLKAIGKVPRHFFFDETFWNQAYRDIAFPIGDGQTISQPYTVAYQSELLHVKKGDKVLEIGTGSGYQTCILMELGADVYTIERQESLYNRTIQVLPYMGYNPKFFLGDGSKGIPGNAPYDKIIVTAGAPFVPEIMLKQLKIGGVFVIPVGDEKAQKMVTILRVGENDFERIELDTFRFVPLVGDQAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ93</accession>
    <name>D7VJ93_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000470.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11062"/>
    <dbReference type="EnsemblBacteria" id="EFK58946">
        <property type="protein sequence ID" value="EFK58946"/>
        <property type="gene ID" value="HMPREF0766_11062"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1416">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127515_4_0_10"/>
    <dbReference type="OrthoDB" id="1829042at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107562" evidence="1">
        <location>
            <begin position="29"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="163" mass="18501" checksum="1DBD908F5256E9CA" modified="2010-10-05" version="1">MDLITFKMMNKKLMLMMLILVSITTVYAQSKDSLQHNKEYTGAEAQLKSYKAIYQLDSNDPKIIEKAIRNINNALDDPRLQGKLQIELITFSGGTEAYLKSSSKFEEPLKKLIQRGVIVAQCLNSLKERNLSKDQLFDFVAYVPSGNGELIIRSLQGWTIIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJD6</accession>
    <name>D7VJD6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, group 1 family protein</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000592.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11105"/>
    <dbReference type="EnsemblBacteria" id="EFK58989">
        <property type="protein sequence ID" value="EFK58989"/>
        <property type="gene ID" value="HMPREF0766_11105"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_35_0_10"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="45"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="210"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="386" mass="44018" checksum="2677373339BE8C80" modified="2010-10-05" version="1">MRILIIHNHYQDLGGEDTVFHQEALALQETDDVFTLTFTNKKGIKGLFQFLLSPWNIFAAQKVKRKIKEVNPDIIHFHNTQYACGPLAIRYAKKSGKALVMSLHNFRLLCPSATLFYRNRLFTDSINQHFPWTAVRNKVLDHSLLKTFWTAFSYWLHRKTGTWNLVDRYMVLAEFSRKLFISSTLPVDHNKFVVKPNFFDPLTLTQPANRQDHFLYIGRLSSEKGIINLLQALSGTSVKLKIAGTGPQLPEVQELVAHYPNLTYLGLLSKPEIAHELATCKALMVPSVCYEGGVPITILEAMSYYTPVLASNIGAIPDIIKPGETGFLFDPQTAESILESIAQLNLLSAEQHKDLVQQAYEIYERHFTRDIVIRKLRSEYQNLIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJE0</accession>
    <name>D7VJE0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000596.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11109"/>
    <dbReference type="EnsemblBacteria" id="EFK58993">
        <property type="protein sequence ID" value="EFK58993"/>
        <property type="gene ID" value="HMPREF0766_11109"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1114514_0_0_10"/>
    <dbReference type="OrthoDB" id="1815576at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="40"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="259" mass="29233" checksum="D6DECBCC9E3D6A23" modified="2010-10-05" version="1">MIQANSLFEGSFSVDSSKKFIPFDKNKDDPKDRPGSMFVHVHPFLIESSAGLILCDAGLGQTDNAGNLIIHNNIRRLGFEPSDVKFVLMSHLHKDHTGGMVEFRDGVGRIAFPEAEYIVQRGEWEDAFSGNSSSYKTDIFDVIQRSGNLVLVEGDGIVNNEISYERNGGHTPHHQVFHIETGGEHYFFGGDVLPEPGEIFHNYIAKYDYDGRKAKDLRQEYWEEGAPNDWVFLFYHSKSIAVGRSQQKDDGSYKLVEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJJ2</accession>
    <name>D7VJJ2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Starch synthase catalytic domain protein</fullName>
            <ecNumber evidence="4">2.4.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">glgA</name>
        <name evidence="4" type="ORF">HMPREF0766_11161</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.21" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000679.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11161"/>
    <dbReference type="EnsemblBacteria" id="EFK59045">
        <property type="protein sequence ID" value="EFK59045"/>
        <property type="gene ID" value="HMPREF0766_11161"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085315_0_0_10"/>
    <dbReference type="OrthoDB" id="992958at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_5" evidence="3">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="276" mass="31342" checksum="A663FFA40A83456D" modified="2010-10-05" version="1">MAKTKILFVTHEMSPFLELSKISEITRQLPQAMQEKGFEIRILMPRFGNINERRNRLHEVIRLSGMNIVVDNNDNPLIIKVASLPAARMQVYFLDNEDYFQRKKVFKNESGEFFDDNNERSVFFCKGVLETVKKLGWSPDVVHCHGWFSALVPAYLKTTYKDDPAFKGAKVMYSLYNEDDFGSSSLHAKYAEIAPEGSMTAEDAANYGSGSYVDVYKGALAFTDVAVIADQGVSQEIIDFAKSRDIQIFEPNGDEDYEAFNDLFDQFAPVEEETTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJN6</accession>
    <name>D7VJN6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit beta</fullName>
            <ecNumber evidence="10">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">atpD</name>
        <name evidence="12" type="ORF">HMPREF0766_11205</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="10"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000768.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11205"/>
    <dbReference type="EnsemblBacteria" id="EFK59089">
        <property type="protein sequence ID" value="EFK59089"/>
        <property type="gene ID" value="HMPREF0766_11205"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022398_0_2_10"/>
    <dbReference type="OrthoDB" id="430176at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="11">
        <location>
            <begin position="145"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="153"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK59089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="500" mass="54634" checksum="3555939F94DE1943" modified="2010-10-05" version="1">MPQIGKIAQIIGPVVDVNFADNENLPKIYDALYIEKENGQRIVLEVQQHLGEDCVRTIAMDATEGLVRGMKVVDTGAPIKMPIGEEIKGRVFNVVGDAIDGIKNLDKTNGRPIHNVPPKFEDLSTESEVLFTGIKVIDLLEPYAKGGKIGLFGGAGVGKTVLIQELINNIAKGHGGLSVFAGVGERTREGNDLLREMLESGIIKYGDHFMEGMEKGEWPLETVDQELMKESKCTFVFGQMNEPPGARARVALSGLTVAEYFRDGEGDGQGKDVLFFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGLMQERITSTKNGSITSVQAVYVPADDLTDPAPATTFAHLDATTVLSRKIAELGIYPAVDPLDSTSRILSPAVLGDEHYNTAQRVKEILQRYKELQDIIAILGMDELSEEDKQTVHRARRVQRFLSQPFHVAEQFTGLKGVLVDIKDTIKGFNMIIDGEVDEYPEAAFNLVGSIEEAIEKGKKLLAEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJQ4</accession>
    <name>D7VJQ4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonucleoside-diphosphate reductase subunit beta</fullName>
            <ecNumber evidence="4">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nrdF</name>
        <name evidence="7" type="ORF">HMPREF0766_11223</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 6">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="4 6">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000821.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11223"/>
    <dbReference type="EnsemblBacteria" id="EFK59107">
        <property type="protein sequence ID" value="EFK59107"/>
        <property type="gene ID" value="HMPREF0766_11223"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052495_1_0_10"/>
    <dbReference type="OrthoDB" id="1384440at2"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026494">
        <property type="entry name" value="RNR_NrdF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000355">
        <property type="entry name" value="NrdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04171">
        <property type="entry name" value="RNR_1b_NrdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="328" mass="37926" checksum="0BA6AA84268563D8" modified="2010-10-05" version="1">MNRKIRAVNWNTPDNDYALMFWEQNIKQFWIDTEYIPSKDIDSWKGLSWDMKECYKKALGGLTLLDTLQSHTGMPKIIDHIDSLQNKAVLSYMCMMEAIHAKSYSTIFTTVSTTNEINDVFGWVEQNKHLQFKAQTIDKYYRSIDKEDPTDEELFMALGASVLLESFLFYSGFFLPLWLCGQGQMVASADIIKKIIADESIHGVFVGLIAQDIFRRIPNKEEVKARFLTLLNELYENELKYTEEIYTVVGLTAEVKEYVRYNGNKALMNLGFDPIFEVKQVNPIVLNGLNTETTQHDFFSKKSTNYEKATEIVHLMNEDFQMDATVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJR8</accession>
    <name>D7VJR8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000862.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11237"/>
    <dbReference type="EnsemblBacteria" id="EFK59121">
        <property type="protein sequence ID" value="EFK59121"/>
        <property type="gene ID" value="HMPREF0766_11237"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1978">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128607_0_0_10"/>
    <dbReference type="OrthoDB" id="1713308at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007405">
        <property type="entry name" value="Phage_KVP40_Orf299"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39961">
        <property type="entry name" value="PTHR39961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04308">
        <property type="entry name" value="RNaseH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="157" mass="18066" checksum="817AEF51EE49A565" modified="2010-10-05" version="1">MNWQKYNGEYIRIPITDAVEEIIARETRLGNKLKVYIGTDSQVKRGTIDFATVIVFLREHKGGFMFIHKDKRTHLMSIKERMLLEVQKSIEIAYHLCPLLDQYHVDLEVHADINTNPNFQSNVALKEAMGYIMGMGFVFKAKPESFASTNCANKLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJU2</accession>
    <name>D7VJU2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998627.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11261"/>
    <dbReference type="EnsemblBacteria" id="EFK58544">
        <property type="protein sequence ID" value="EFK58544"/>
        <property type="gene ID" value="HMPREF0766_11261"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2036561_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="121" mass="13889" checksum="9154E220446A4615" modified="2010-10-05" version="1">MINRSSHITLRASTLVEVLIALLIIMSVFAAGMVIFANINKASRSQTQQQIKMQLKDLQKEYEKYPVATEEHIIRDSIAYTIRIVTSQDYPRLKRITASARHPHNDLILDSLVVLKENRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK02</accession>
    <name>D7VK02_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11321</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11321"/>
    <dbReference type="EnsemblBacteria" id="EFK58604">
        <property type="protein sequence ID" value="EFK58604"/>
        <property type="gene ID" value="HMPREF0766_11321"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_1_2_10"/>
    <dbReference type="OrthoDB" id="554994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="78"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="279"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="504" mass="58084" checksum="ADBBF20A566C9DC2" modified="2010-10-05" version="1">MLNFNYLKRIKMKTNKFFYIAVFVFFGLMSSCELQREEFDRILPENFYKNEEDIKSAVTAAYNNFHINSYSGGGVYSSSIGGINIYTEVSTDIMDCQWGDNGNWELFNTHSWTAADPRYSEKLYAKYKNVSQIRNIILQIEKSEVRDELKQRYIGELKALRGWLLYCLLDIYGPVPIAPDEALKDPVVELILERPAETEYVAQVESELKDAIRMLPLKGSEWGRVGAGAANMMLLKLYMHQKRWKEGEAIGRELMNAKYGYRLLDNYYDCFSLNTEVNNENIWVIPCNTENYANGWISHVLPGDYPYPNPAVEAWSGYRMPWDFYHTFEKKDKRLANIISEYVSKADGTVRNEQNPAGELIKGALPVKYTVDPNQKGDRGGIDVPVFRYSDVLLTLAESIARQGTVTQECMDLVNTVRRRAGLENLSLANYGDLNNFLDMLLLERGHELYCEGHRRTDLIRYGKYVEFNRRVANSHSADYKVLFPIPNSYLLESKGKIKQNTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK32</accession>
    <name>D7VK32_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11351"/>
    <dbReference type="EnsemblBacteria" id="EFK58634">
        <property type="protein sequence ID" value="EFK58634"/>
        <property type="gene ID" value="HMPREF0766_11351"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3930">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026435_0_0_10"/>
    <dbReference type="OrthoDB" id="504489at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012548">
        <property type="entry name" value="DUF1704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31817">
        <property type="entry name" value="PTHR31817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08014">
        <property type="entry name" value="DUF1704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01154">
        <property type="entry name" value="DUF1704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="613" mass="70179" checksum="0A7E6EBC4FC55E3B" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK55</accession>
    <name>D7VK55_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">rpsR</name>
        <name evidence="5" type="ORF">HMPREF0766_11374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998940.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11374"/>
    <dbReference type="EnsemblBacteria" id="EFK58657">
        <property type="protein sequence ID" value="EFK58657"/>
        <property type="gene ID" value="HMPREF0766_11374"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148710_2_0_10"/>
    <dbReference type="OrthoDB" id="1940575at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="87" mass="10175" checksum="D96C2E3493170928" modified="2010-10-05" version="1">MANENIQYVTAPKVEDNRKKYCRFKKNGIKYIDYKDANFLLKFVNDQGKILPRRLTGTSLKFQRKVAQAVKRARHIGLLPYVTDSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK71</accession>
    <name>D7VK71_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11390"/>
    <dbReference type="EnsemblBacteria" id="EFK58673">
        <property type="protein sequence ID" value="EFK58673"/>
        <property type="gene ID" value="HMPREF0766_11390"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_2_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="175"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="280" mass="31979" checksum="D1179CCD2D7BA815" modified="2010-10-05" version="1">MSEMSTEFAVLRTPIQIHDIAKTSGFIKVPTPLHRPEFNFIVHITGGSAKQQVDANLVSLKKNEILFVRQGNVTSLKEVSPDATGYMILFEDQTLNQLLSKQELIKLFSANVVIQLPEESSIWLNSLFELLSIELYHPNPNLGICYSLFQAGLQKIFTSSKELNKNMNRSAEVTFNFKELVYKHYQEHKIILFYAAKLSVSENYLHRCVSETIGESPKEWINKVSILQSQLLLQDLTKSISEIAFELNYGDPSYFGRLFKKITGITPSEYRIAFMQDLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKC1</accession>
    <name>D7VKC1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease Y</fullName>
            <shortName evidence="5">RNase Y</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ymdA</name>
        <name evidence="5" type="synonym">rny</name>
        <name evidence="8" type="ORF">HMPREF0766_11440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endoribonuclease that initiates mRNA decay.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999119.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11440"/>
    <dbReference type="EnsemblBacteria" id="EFK58723">
        <property type="protein sequence ID" value="EFK58723"/>
        <property type="gene ID" value="HMPREF0766_11440"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028328_1_0_10"/>
    <dbReference type="OrthoDB" id="1012190at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00335">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017705">
        <property type="entry name" value="Ribonuclease_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022711">
        <property type="entry name" value="RNase_Y_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF15">
        <property type="entry name" value="PTHR12826:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12072">
        <property type="entry name" value="RNase_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03319">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="7">
        <location>
            <begin position="335"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="29"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="519" mass="58408" checksum="5A5FD8C4B53463A1" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKH4</accession>
    <name>D7VKH4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Antioxidant, AhpC/TSA family</fullName>
            <ecNumber evidence="6">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_11493</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.15" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999266.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11493"/>
    <dbReference type="EnsemblBacteria" id="EFK58776">
        <property type="protein sequence ID" value="EFK58776"/>
        <property type="gene ID" value="HMPREF0766_11493"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_1_1_10"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107334" evidence="4">
        <location>
            <begin position="20"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="316"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="458" mass="51387" checksum="D4D68C15A64904D9" modified="2010-10-05" version="1">MKKTLLIFISALSGLAAFAQSPVEIKGSLEKEFLKPVKLFKVVEGNAVEIATSTPQGEGKFGFIFYPQYEGLYALGTGNSGSPNDNYKFYFKSGDKLSVRLLDSSYVLTGTENSKENQILTQWHDLVFPLEQKAINFMKVQSTFVDFFPDLESITEKAKGFEQGKLSGNPKFDKHLKSYMNSDLALYATNFLSTPRSAHPATDELSPFYETIKAKDFATTTQLVYENPWGRRLLSGIIMLNMKQEKIKYAQGIQGVKDQFVFLPNDTLKGDAVLDAVSRLKTFEAYKEIMDQYGSLIVTSSQKKRNMDIMAELAQLKAGDAGLNFAYPDPNGKTVKFEDLRGKVVLIDVWATWCGPCKAEIPYLKKLEEEMKGTNLQIVSISVDEAKDKAKWAKMIKDENLGGLQLFASGWGDLAQYYKIKGIPRFMIFDKEGKIVTTDSPRPSNPELKTLLNKILQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKM2</accession>
    <name>D7VKM2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK58824">
        <property type="protein sequence ID" value="EFK58824"/>
        <property type="gene ID" value="HMPREF0766_11541"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3189164_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="46" mass="5562" checksum="8E91AA125B75AFC1" modified="2010-10-05" version="1">MEGLIYFFLYRKYADLLLLLSQISKYLKAQQTLHKWVIYSGTDLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL34</accession>
    <name>D7VL34_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-70 region 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11703</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999745.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11703"/>
    <dbReference type="EnsemblBacteria" id="EFK58307">
        <property type="protein sequence ID" value="EFK58307"/>
        <property type="gene ID" value="HMPREF0766_11703"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_3_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="102"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="163" mass="19253" checksum="1752627DD1140E1B" modified="2010-10-05" version="1">MDIEKEFIGLITSNQAIIHRICCMYVDNRTDREDLFQEIILQSWKSFKSFRGDSRFQTWLYRVGLNTAITYIKRDRKHMDAELQFTQESYCDIIYQENEEILAMYRAIGQLSKIEKALVALYLEDYSYKEIGDTMGMTANHVAVKISRIKEKLKDLSKKQLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL64</accession>
    <name>D7VL64_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">rimM</name>
        <name evidence="4" type="ORF">HMPREF0766_11733</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999806.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11733"/>
    <dbReference type="EnsemblBacteria" id="EFK58337">
        <property type="protein sequence ID" value="EFK58337"/>
        <property type="gene ID" value="HMPREF0766_11733"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0806">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077636_4_1_10"/>
    <dbReference type="OrthoDB" id="1497415at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RimM" evidence="3">
        <location>
            <begin position="9"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="174" mass="20241" checksum="AE6B2A0DCB63BD85" modified="2010-10-05" version="1">MTIDQSFYIGYISKTRGLKGELQLFFEFEDYQDLDIDVLFVEINKKLVPYFVENIKLQSNSTAYLNLEDVDHIDKAQPLVHKKLYLPNDKMPERDPDDFRLTDLKGFLVIDEVHGELGEIVEVQELPQQFIARVDFNGKELMFPLNDDLILGIDPEEEIIEVDLPEGLVELYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLB0</accession>
    <name>D7VLB0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11779"/>
    <dbReference type="EnsemblBacteria" id="EFK58383">
        <property type="protein sequence ID" value="EFK58383"/>
        <property type="gene ID" value="HMPREF0766_11779"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2702946_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="73" mass="8936" checksum="8DDE4596D48EDF33" modified="2010-10-05" version="1">MQMFMQTFVKSIDRLKNLIILIKKLQFYINYTKDITKEERIQGVEPLSKPKPYHKTKKMVYIRIRQCIFKKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLD0</accession>
    <name>D7VLD0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma factor regulatory protein, FecR/PupR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000007.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11799"/>
    <dbReference type="EnsemblBacteria" id="EFK58403">
        <property type="protein sequence ID" value="EFK58403"/>
        <property type="gene ID" value="HMPREF0766_11799"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050192_2_2_10"/>
    <dbReference type="OrthoDB" id="1381035at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032508">
        <property type="entry name" value="FecR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16344">
        <property type="entry name" value="DUF4974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="126"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4974" evidence="3">
        <location>
            <begin position="251"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="320" mass="36977" checksum="EE0C5F8AB33DDA44" modified="2010-10-05" version="1">MKDVLVTKYIVGDASPEEVLVVEQWISSNHENEKVYQQMKKAWELSKQTTVPEDIDIDRVWADFVRRKNEREETQVKYEKPSRVFSVKWMIAAVTLLCLGISLYFFATQSAVDKQLQSFADVRRDQLPDGSVVTLNKYSEIAYSESWLSKNRSVKLTSGEVFFEVKRDEKHPFVIDAGKTKITVLGTSFHVRRGNGETEVIVASGSVSVRSADQEVILKPLQSVLINDTLKNRLRVDTVPDQLYRYYVHQEFVFENTPLPRVLEILNKAYDQHLVLSNPKHRQLLLTATFEQQPLSEIIKVILETFDLKIEKKGNQYHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLD4</accession>
    <name>D7VLD4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK58407">
        <property type="protein sequence ID" value="EFK58407"/>
        <property type="gene ID" value="HMPREF0766_11803"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1915764_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107074" evidence="1">
        <location>
            <begin position="22"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="132" mass="14710" checksum="1AA11F55D70D997F" modified="2010-10-05" version="1">MRTGVLITFIAIIFTSSMVSCSTTVKLGLSGKYNIKHVQSEEIGKNKVAIAINLFDIKTKDKIAIADVKNLPGIVIDSSSNYKLLLFDRDSLPRSIRINKKGRMPLPLHPEKSKKNLLIIKVYLSEDIRGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLF6</accession>
    <name>D7VLF6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_11826</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000080.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11826"/>
    <dbReference type="EnsemblBacteria" id="EFK58429">
        <property type="protein sequence ID" value="EFK58429"/>
        <property type="gene ID" value="HMPREF0766_11826"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_2_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107016" evidence="5">
        <location>
            <begin position="22"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="115"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="418"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1026" mass="113621" checksum="4803C090E162EDE1" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLH8</accession>
    <name>D7VLH8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_11848</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000141.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11848"/>
    <dbReference type="EnsemblBacteria" id="EFK58451">
        <property type="protein sequence ID" value="EFK58451"/>
        <property type="gene ID" value="HMPREF0766_11848"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_3_10"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="126"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="126"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="225" mass="26290" checksum="1FE6078EFE2F7E19" modified="2010-10-05" version="1">MISILYVEDEAGLAMILSDTLRSHGFAVTHCDNGGEAFSTFQEQKYDLLLIDVMMPVMDGFELAKKVRGMDTDVPIIFLTARTQTEDVVAGFHLGANDYIKKPFKIEELIVRIEALFKYYNRAQSVPKLQIGNYILDHVKHLLTFEDMEEKLSFRESELLRRLFENKDRVVPREEIIKAYWSQDKYFTGRSLDVFISRMRKYLIKDERIKIINIRGIGYMLTIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLW2</accession>
    <name>D7VLW2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="1">2.7.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cysC</name>
        <name evidence="2" type="ORF">HMPREF0766_11959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the APS kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK57967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001041.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11959"/>
    <dbReference type="EnsemblBacteria" id="EFK57967">
        <property type="protein sequence ID" value="EFK57967"/>
        <property type="gene ID" value="HMPREF0766_11959"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046932_2_3_10"/>
    <dbReference type="OrthoDB" id="1574819at2"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="185" mass="20659" checksum="D99F22586A330893" modified="2010-10-05" version="1">MALIIQMTGLSGSGKTTLSKMLKTTLEEDSYRVALVDGDTYRATLCKDLGFSKADRIENIRRLGVVSVELSKEYDIVIIAAINPYEEGRSLLKQDNSNSQLVYIKCDLQTLIKRDPKGLYERALLPEGQPGRIDQFTGISDVFEIPQEPAVTIDTANTSPEECIAQLKVFVLTYSKVKDESYRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM32</accession>
    <name>D7VM32_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12029"/>
    <dbReference type="EnsemblBacteria" id="EFK58037">
        <property type="protein sequence ID" value="EFK58037"/>
        <property type="gene ID" value="HMPREF0766_12029"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_507965_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026341">
        <property type="entry name" value="Bac_Flav_CTERM"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04131">
        <property type="entry name" value="Bac_Flav_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="514" mass="56229" checksum="42A6DC72A093E3D7" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM89</accession>
    <name>D7VM89_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001373.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12086"/>
    <dbReference type="EnsemblBacteria" id="EFK58094">
        <property type="protein sequence ID" value="EFK58094"/>
        <property type="gene ID" value="HMPREF0766_12086"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_5_2_10"/>
    <dbReference type="OrthoDB" id="2057904at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="119" mass="13726" checksum="C2CE000D321C0039" modified="2010-10-05" version="1">MKTKESTIIEKICPLEFAVNAISGKWKIPIVWQINEGKKRPSEFLRGIGKVDRRVLNQQLKEMEQAGILTKEQFAELPPRVEYSLTPIGEKLVEALWLLNDWGKVLLDREKPTSETDNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMI5</accession>
    <name>D7VMI5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12182"/>
    <dbReference type="EnsemblBacteria" id="EFK58190">
        <property type="protein sequence ID" value="EFK58190"/>
        <property type="gene ID" value="HMPREF0766_12182"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2439251_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="90" mass="10594" checksum="49AF30506DE12984" modified="2010-10-05" version="1">MAILPVLCLPILFYTTKNWKFHIAYNDVKSIKKMAAVYKAWIRKKEQGEKMSLYDIFQFNGEDIIWGGSENLEKESTITAFEKSFKMDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMP1</accession>
    <name>D7VMP1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_12261</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992717.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12261"/>
    <dbReference type="EnsemblBacteria" id="EFK57188">
        <property type="protein sequence ID" value="EFK57188"/>
        <property type="gene ID" value="HMPREF0766_12261"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107350" evidence="5">
        <location>
            <begin position="21"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="115"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="417"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK57188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1061" mass="117177" checksum="A3B7B0AA5F977664" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMQ2</accession>
    <name>D7VMQ2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pectate lyase</fullName>
            <ecNumber evidence="2">4.2.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pelA</name>
        <name evidence="2" type="ORF">HMPREF0766_12272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992729.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12272"/>
    <dbReference type="EnsemblBacteria" id="EFK57199">
        <property type="protein sequence ID" value="EFK57199"/>
        <property type="gene ID" value="HMPREF0766_12272"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053823_0_0_10"/>
    <dbReference type="OrthoDB" id="227712at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012669">
        <property type="entry name" value="Pectate_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09492">
        <property type="entry name" value="Pec_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02474">
        <property type="entry name" value="pec_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107443" evidence="1">
        <location>
            <begin position="20"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="343" mass="39499" checksum="84F3C547EA9EAD48" modified="2010-10-05" version="1">MKKTLGILFILMSAGIVHAQTQIDTLADKMLRYQLPVGAWSKQLADKSTVDYSKPIDKSLADKIRKTTDQYATIDNKATSREIEYLIQAYHKTKNPAYLKAVERGIEYLLKMQYPNGGFPQYYPNASLYRGEITYNDNAMINALDILYNVSNKLEGYEVVRSGLSKRAQNAVSRGLDCILKTQVRQNGTLTIWAAQYDQNTLQPAKARNFEPASLSTSESMGVVKFLMRLEQPSAEVIQAVKSAKKWFETNDIEGYRFDFSKDPETNKPTRQLVKDPDAVVWARFYDLKDNRPIFGDRDNSVKYNLSEVSEERRNGYAWYGVWPLNFVQKDYQKWLKKNKIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMX9</accession>
    <name>D7VMX9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12349"/>
    <dbReference type="EnsemblBacteria" id="EFK57276">
        <property type="protein sequence ID" value="EFK57276"/>
        <property type="gene ID" value="HMPREF0766_12349"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3296702_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="40" mass="4513" checksum="35D5CAB7C352E3BD" modified="2010-10-05" version="1">MGLAFYYKQEDNIKNGAICYQIFLLIFLNTSASCSSAINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMZ9</accession>
    <name>D7VMZ9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12369"/>
    <dbReference type="EnsemblBacteria" id="EFK57296">
        <property type="protein sequence ID" value="EFK57296"/>
        <property type="gene ID" value="HMPREF0766_12369"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2289877_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107723" evidence="1">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="105" mass="11439" checksum="96C1FC448D5F93AF" modified="2010-10-05" version="1">MKKNMIMLMALSLITALLMSFVVRSDKKYGGTASASGKVTYVTTYESTQGRKVGDIETINVAVDCMYDDNAEAKKALKTEIENTAIVKKITLTGAINYDVTTCNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNG8</accession>
    <name>D7VNG8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993113.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12538"/>
    <dbReference type="EnsemblBacteria" id="EFK57465">
        <property type="protein sequence ID" value="EFK57465"/>
        <property type="gene ID" value="HMPREF0766_12538"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503387K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_993597_0_0_10"/>
    <dbReference type="OrthoDB" id="1181656at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="278" mass="31318" checksum="A5D6EAE76A2C3F40" modified="2010-10-05" version="1">MKENNTYHDHTEGNNLPESLRVNPFAVPKDYFENLGSGLCSKIRLLNAAPSEKESFSTPENYFNDLQSRIMTAVKLDQLKTDTEENGFTVPSNYFDQLQQQITANITADRWKDQLKDEGFAVPEDYFNTLEDSIFAGIATDRLKAEVKEDGYTVPSNYFDQLSADIQAKAFEKEQPKIVPIGGLKRRNWMRYAAAASVTLILGLGAYFGIQQEETATTDLHSELANVSDAEIINYLAATNSGDNMVYFTQYIYEPEESAGVGSQIDNEDIEEYLKYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNM3</accession>
    <name>D7VNM3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conjugative transposon protein TraE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">traE</name>
        <name evidence="4" type="ORF">HMPREF0766_12593</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993181.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12593"/>
    <dbReference type="EnsemblBacteria" id="EFK57520">
        <property type="protein sequence ID" value="EFK57520"/>
        <property type="gene ID" value="HMPREF0766_12593"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031KUP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158438_0_0_10"/>
    <dbReference type="OrthoDB" id="1636862at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025408">
        <property type="entry name" value="DUF4134"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13572">
        <property type="entry name" value="DUF4134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107736" evidence="2">
        <location>
            <begin position="24"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4134" evidence="3">
        <location>
            <begin position="9"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="101" mass="10503" checksum="655EE9FB1DA303B8" modified="2010-10-05" version="1">MKKQSKKVLLAAVAMLSGMGAFAQGNGSAGINEATQMVTSYFDPATQLIYAIGAVVGLIGGVKVYNKFSSGDPDTSKTAASWFGACIFLIVAATILRSFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNN2</accession>
    <name>D7VNN2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993192.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12602"/>
    <dbReference type="EnsemblBacteria" id="EFK57529">
        <property type="protein sequence ID" value="EFK57529"/>
        <property type="gene ID" value="HMPREF0766_12602"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7U6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073324_0_0_10"/>
    <dbReference type="OrthoDB" id="856184at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043766">
        <property type="entry name" value="DUF5712"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18976">
        <property type="entry name" value="DUF5712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="324" mass="37353" checksum="131E2ED78D9DA732" modified="2010-10-05" version="1">MYINITDSETGNNKGSSGQLVGYLEKENRTALEESRENELWFNNLNKNITPQEVRVKIDNNIAKLSRNDAKFFLINISPSEKEIIYLKEQFGEKGAEEKLKEYAACVMDAYARNFKRPGIESGKDLLWYGKLERYRYHYHTDEEVKQGAVKAGERKAGEQMHIQIIVSRKDITNKIKLSPLNNSRGRNEQHSVKLGQFDRVAFKESGELLFDRMFNYNRSLKDSMNYALTMKSGNPEQKRAIHLLDQLESKLTDTERQNIPDTAKDIYQNNNTDLAQLIDIIGDSAVSILGTLFSSDPLLYEHTDDQVPHFKKKKKRKRRPGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNN6</accession>
    <name>D7VNN6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993197.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12606"/>
    <dbReference type="EnsemblBacteria" id="EFK57533">
        <property type="protein sequence ID" value="EFK57533"/>
        <property type="gene ID" value="HMPREF0766_12606"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_7_3_10"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="124" mass="14418" checksum="08B0800F3D057D3C" modified="2010-10-05" version="1">MGNNSCIRQQADIEQINRCKDRVLELNDSFDYLSNGLELAGNTVRLKILFLLYEEKRLCVCDISDVLGMTISAVSQHLRKLKDRNLVETDREAQTIFYSLTKEYEKLLKPFFKILDENKVIEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNQ4</accession>
    <name>D7VNQ4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993225.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12624"/>
    <dbReference type="EnsemblBacteria" id="EFK57551">
        <property type="protein sequence ID" value="EFK57551"/>
        <property type="gene ID" value="HMPREF0766_12624"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032SB1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142273_1_0_10"/>
    <dbReference type="OrthoDB" id="1635052at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08026">
        <property type="entry name" value="DUF326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005560">
        <property type="entry name" value="DUF326"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044543">
        <property type="entry name" value="YHJQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03860">
        <property type="entry name" value="DUF326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="111" mass="12201" checksum="55B11DB97C799B07" modified="2010-10-05" version="1">MSHQQFQKCIDECYACAVACNHCAASCLQEDNVKMMARCIQLDLECAAICRAAAELMSLGSQYSRHLCKLCAEICRACGDECAKHDMQHCKECADACYKCAEACEQMATAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNQ7</accession>
    <name>D7VNQ7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993229.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12627"/>
    <dbReference type="EnsemblBacteria" id="EFK57554">
        <property type="protein sequence ID" value="EFK57554"/>
        <property type="gene ID" value="HMPREF0766_12627"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9MY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116247_0_0_10"/>
    <dbReference type="OrthoDB" id="1875603at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015082">
        <property type="entry name" value="DUF1896"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036297">
        <property type="entry name" value="PG0816-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08989">
        <property type="entry name" value="DUF1896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140753">
        <property type="entry name" value="SSF140753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="145" mass="16973" checksum="64DB4F0485A91A6C" modified="2010-10-05" version="1">MSTQQKDLSYFRLRLQELLNSSFPEKASNQKFIDQRSSWAANAYEDAFRSGNAIEQCNEIANYILFEGLHFSKFDMVFQVVCNEFDTLMADEELRRFALKMFPVCENVFAQYELADDFAYGYEFDLLYTEITGTIAIWIEENGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNV7</accession>
    <name>D7VNV7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12677</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993312.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12677"/>
    <dbReference type="EnsemblBacteria" id="EFK57604">
        <property type="protein sequence ID" value="EFK57604"/>
        <property type="gene ID" value="HMPREF0766_12677"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZR67">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_642356_0_0_10"/>
    <dbReference type="OrthoDB" id="468655at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14948">
        <property type="entry name" value="BACON"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024361">
        <property type="entry name" value="BACON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13004">
        <property type="entry name" value="BACON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19190">
        <property type="entry name" value="BACON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107173" evidence="1">
        <location>
            <begin position="34"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="BACON" evidence="3">
        <location>
            <begin position="53"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="BACON" evidence="2">
        <location>
            <begin position="175"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="427" mass="46668" checksum="A15FB2A11862D4A1" modified="2010-10-05" version="1">MKLMKTNNYYSLKALPKAIMAFCLSLTILFSSCKDENEINNFLTLKDNPSKMEAAANGSSATFTVQSGGNWKVQPLRKEHWFKIDPAEGSGDGTFTVTVTKNKDQEVRTMTLFFTVNGQLQSNVLKIEQAAATTGEQQKDPYLKIDGISEKLDVPEAGLTGNYILRSTGKWKIAPEEGADWLEISPAEGSGDTPVTIRVNKNTDIERTANLLLFLDDVQQATPLTVYQKGVKLQVEGDVVLNENFNWLTYGSEIFSVTTGETRIGSWTSAEVAKGWTSTVNTTEGGGSYASIYARPGFIKLGRTNYGGDLISPKLANVQRTKNLLVTFKAVRYASGDHNVLTAGVKGPGKVSVSEFKINNTPATNSNLESSRASWKAPEATYSFVITGATSETQFWLLGGAFDQRSGNWPSTVNRIFIDDILVTVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNX2</accession>
    <name>D7VNX2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urease accessory protein UreE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">ureE</name>
        <name evidence="7" type="ORF">HMPREF0766_12692</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UreE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993338.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12692"/>
    <dbReference type="EnsemblBacteria" id="EFK57619">
        <property type="protein sequence ID" value="EFK57619"/>
        <property type="gene ID" value="HMPREF0766_12692"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2371">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093757_3_0_10"/>
    <dbReference type="OrthoDB" id="1663151at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019627">
        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00822">
        <property type="entry name" value="UreE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012406">
        <property type="entry name" value="UreE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007864">
        <property type="entry name" value="UreE_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004029">
        <property type="entry name" value="UreE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036118">
        <property type="entry name" value="UreE_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05194">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02814">
        <property type="entry name" value="UreE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00988">
        <property type="entry name" value="UreE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69287">
        <property type="entry name" value="SSF69287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0533">Nickel</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UreE_N" evidence="6">
        <location>
            <begin position="7"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="176" mass="20026" checksum="DB0E5D1D6E386C12" modified="2010-10-05" version="1">MIRAHNIAGNIYGSSQSFGGLETDYLELEWYEADKGILRRFTTGGREIGFRNQTAQSLEDGDVIFSDASICIVIRILPCLCLVIHPENMLEMANVCFEIGNRHLPVSIRSSSEVVIAYEDPLYRLFVKQGYHTIVEDRVLQQTQTLRIHEWTQKTKFKITLASKINESFVDPAADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNZ7</accession>
    <name>D7VNZ7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993383.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12717"/>
    <dbReference type="EnsemblBacteria" id="EFK57644">
        <property type="protein sequence ID" value="EFK57644"/>
        <property type="gene ID" value="HMPREF0766_12717"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_658637_0_0_10"/>
    <dbReference type="OrthoDB" id="1533572at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="486" mass="55519" checksum="679C58C4EB793678" modified="2010-10-05" version="1">MYSIKTPGFCSPDATFRSEKKNNGCDSDCVRMIKSDVITEFSVLKGLTAFTTDYLSVYLKILFIIPLNAVLRIAANLFILLFMCFPVADAQERQVLSLETILQQIDQHNLLLKTYGLKAESYLQNAEAATAWMAPMIGVGTFMTPYPGQMIMDGRDRGSLMLQLEQDIPNFAKLNADRKYIRSQANVERATRDVTLNDLRTTAKKLYYTWLVAKMKLSVLDKSTHIMQTMRKLEEVRYPFNQSRLGAVYQTVAKLEETENMKRMQEGEIGRAMAALNGMMNRSGNTAFTIDTTLVPQFIIAGSLDTASLAAARKDIAKMDYNIQSMHLNIHAMKKQSSPEFRFRFDHMSPFGSGMPKAYSVMGMVSIPIAPWSSKMYKSEIKGMQYEVEAMQMEKAAMLQETQGMLYGMQYQIKTMEQQILAMEKKIIPTLEKTLEVSVLSYRENKMQLPEVITAWEAYNMMQSNVLDEKLKLYLMIADYEKELYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP36</accession>
    <name>D7VP36_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993450.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12756"/>
    <dbReference type="EnsemblBacteria" id="EFK57683">
        <property type="protein sequence ID" value="EFK57683"/>
        <property type="gene ID" value="HMPREF0766_12756"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025928_1_0_10"/>
    <dbReference type="OrthoDB" id="251905at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041662">
        <property type="entry name" value="SusD-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12771">
        <property type="entry name" value="SusD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005672199" evidence="1">
        <location>
            <begin position="23"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="532" mass="59279" checksum="8D1581DBF3A4B95D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP48</accession>
    <name>D7VP48_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA methyltransferase, TrmH family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993468.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12768"/>
    <dbReference type="EnsemblBacteria" id="EFK57695">
        <property type="protein sequence ID" value="EFK57695"/>
        <property type="gene ID" value="HMPREF0766_12768"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_3_2_10"/>
    <dbReference type="OrthoDB" id="1697536at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="26"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="249" mass="27688" checksum="3C55D83A7809D6F7" modified="2010-10-05" version="1">MLSKAQISLITSLQHKKFRKQHGLFVVEGIKSVTEFLSSAYDVHALFYTANVTTKVVKIPHNIKSYELTDNEFSKISQLKSPQGILALVRLPKEKTPEQLDFANQFTLVLDDVQDPGNLGTIIRTAEWFGFKHIVCSAGTVDAYNPKVVQATMGSLSRTQIHYTDLESFIRTVRLPVFGALLDGTSIYETRWGKEGLILMGNEGNGISEKLLDLIDHAVTIPRTGQAESLNVAVATTIFCNEIARMNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP74</accession>
    <name>D7VP74_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993510.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12794"/>
    <dbReference type="EnsemblBacteria" id="EFK57721">
        <property type="protein sequence ID" value="EFK57721"/>
        <property type="gene ID" value="HMPREF0766_12794"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112806_0_0_10"/>
    <dbReference type="OrthoDB" id="1717097at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011466">
        <property type="entry name" value="DUF1572"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07609">
        <property type="entry name" value="DUF1572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="187" mass="21987" checksum="95FB10BDA72EBD8A" modified="2010-10-05" version="1">MAYLVSVLKQFEYYKNLADSTFVQLNDQQLFWLSHEDSNSIALIIQHLAGNMLSRWTNFLTEDGEKSWRNRDEEFELQYANRDELLTYWESGWDCLFGVLRGLKESDLDRIIYIRNQGHSVLEAINRQLAHYPYHVGQIVILGKMQAGSNWKSLSIPKGKSQTYNQEKFAQKPHREHFTDEVLKPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP95</accession>
    <name>D7VP95_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable transaldolase</fullName>
            <ecNumber evidence="9">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tal</name>
        <name evidence="10" type="synonym">fsa</name>
        <name evidence="10" type="ORF">HMPREF0766_12815</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the transaldolase family. Type 3B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="9"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993569.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12815"/>
    <dbReference type="EnsemblBacteria" id="EFK57742">
        <property type="protein sequence ID" value="EFK57742"/>
        <property type="gene ID" value="HMPREF0766_12815"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079764_0_0_10"/>
    <dbReference type="OrthoDB" id="784333at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00956">
        <property type="entry name" value="Transaldolase_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00494">
        <property type="entry name" value="Transaldolase_3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022999">
        <property type="entry name" value="Transaldolase_3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004731">
        <property type="entry name" value="Transaldolase_3B/F6P_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033919">
        <property type="entry name" value="TSA/FSA_arc/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00875">
        <property type="entry name" value="fsa_talC_mipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK57742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="219" mass="23229" checksum="FADF8177EEC4DD52" modified="2010-10-05" version="1">MKFFIDTANLDQIKEAQDLGVLDGVTTNPSLMAKEGISGDENVINHYKAICAIVEGDVSAEVISTDYENMIKEGEALAALDDKIVVKVPMIKDGIKAIKYFSKKGIKTNCTLVFSAGQALLAAKAGATYVSPFIGRLDDISTDGLALIEDIRLIYDNYGFTTQILAASVRHSAHILGCAKIGADVMTGPLSAIVSLLKHPLTDSGLAQFLADHAKAAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPC6</accession>
    <name>D7VPC6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cell shape protein MreC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mreC</name>
        <name evidence="7" type="ORF">HMPREF0766_12846</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MreC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993614.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12846"/>
    <dbReference type="EnsemblBacteria" id="EFK57773">
        <property type="protein sequence ID" value="EFK57773"/>
        <property type="gene ID" value="HMPREF0766_12846"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1792">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042663_5_0_10"/>
    <dbReference type="OrthoDB" id="837894at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042177">
        <property type="entry name" value="Cell/Rod_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042175">
        <property type="entry name" value="Cell/Rod_MreC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007221">
        <property type="entry name" value="MreC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34138">
        <property type="entry name" value="PTHR34138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04085">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="222"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="277" mass="31312" checksum="F158B0673DA91CDF" modified="2010-10-05" version="1">MRNLWLFLIRYNAFFWFVLFFVFSVILVVKNNTFQRATAFNSSNVVIGNMYAKVNSWKSYLALADANEQLVKENAILHNQLQRYTVKDSSDSVRLVDSIEEGRYQFIVANVANNSIHQKSNYLTLDKGSKDGVEKDMGVITSNGVVGIVLNVSKDFCTVQSLLHPDTRISVTLGKSEVFGSLMWGNNRDSRYAMVRDIPNHVKVAKGEQVYTSGFSIFPKGIQVGRIVETGITSGESFLDLRLLLSTNFSNLQHVYILKDKMAEEKRLLEETNNDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPG5</accession>
    <name>D7VPG5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993688.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12885"/>
    <dbReference type="EnsemblBacteria" id="EFK57812">
        <property type="protein sequence ID" value="EFK57812"/>
        <property type="gene ID" value="HMPREF0766_12885"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111510_0_0_10"/>
    <dbReference type="OrthoDB" id="1822108at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010708">
        <property type="entry name" value="5'(3')-deoxyribonucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06941">
        <property type="entry name" value="NT5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="176" mass="20724" checksum="B2524D33D5703A36" modified="2010-10-05" version="1">MVQQKIIALDMDGVLADNQQHYLTYYYNETGIRLDPSTMLGKPEGLGLPDKTAIYRYLHTEGYFRTLPVAEDAIEVVRELQSKYTIYVVSAAIEFPHSLREKFDWLAEYFPFISWKNIVFCGDKSIIKTDYLLDDHISNLRTFQGKPLLFNSFHNVNEQDYERLMNWKEVGEYFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPH3</accession>
    <name>D7VPH3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993709.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12893"/>
    <dbReference type="EnsemblBacteria" id="EFK57820">
        <property type="protein sequence ID" value="EFK57820"/>
        <property type="gene ID" value="HMPREF0766_12893"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_1_1_10"/>
    <dbReference type="OrthoDB" id="1031920at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="157"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="347" mass="40235" checksum="A0AEBC136B3090E4" modified="2010-10-05" version="1">MLFFKLPANKNYLIHVSAWTICILYFLVVFGLLIWSGTTKEIALYDAGINALSITLCCYILSSTINFFLPRKGQMLRLSAIGLIVVALGLYVSRIILLQIFSLIDISYFDFSIPYRVILNFLVLFCIAILQIVWNIQEEYEENKKRKEESEKMVRDAELYNLRQQLQPHFLFNSLNSIIALIGIKPEKAREMTFQLSDFLRGTMRKDNLSLISLKDELSHLQLYLDIEKVRFGHRLNTEVHFPEELSETKLPTMIIQPLLENAIKFGLYNITGDVLIKVEVSYADNLLWIRITNPIENDQYENTKGTGFGLSSVQRRLFLIFGRTDLLFTETKDKSFISTLKIPQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ02</accession>
    <name>D7VQ02_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993971.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13056"/>
    <dbReference type="EnsemblBacteria" id="EFK55853">
        <property type="protein sequence ID" value="EFK55853"/>
        <property type="gene ID" value="HMPREF0766_13056"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5646">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128703_1_0_10"/>
    <dbReference type="OrthoDB" id="1278667at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="22"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="116" mass="13276" checksum="52FCD20D4963D084" modified="2010-10-05" version="1">MISVEEYIASFPKEISERLTIIPKLIKDCIEELAEGMAYKMPSYKYKGRPLVYFAGYPQHIGFYATPSGNIAFEKELASYKQGKGSVQFPHDRPLPLDLIKRIVLFRMEENVGKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ55</accession>
    <name>D7VQ55_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lexA2</name>
        <name evidence="2" type="ORF">HMPREF0766_13109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994053.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13109"/>
    <dbReference type="EnsemblBacteria" id="EFK55906">
        <property type="protein sequence ID" value="EFK55906"/>
        <property type="gene ID" value="HMPREF0766_13109"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074799_0_0_10"/>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="259" mass="29445" checksum="9E68A4F627063208" modified="2010-10-05" version="1">MSNIASNLKYIRKKKGLTQQQFADLMEIKRASVGAYEEDRAEPKYELLKKIAEYFDLTMDELANDVIDDKWKPTPRSNASNLRVLSVTVDQQDRENIELVPVKASAGYLNGYGDPEYVAELPKFSLPMFNQGTYRAFEIKGDSMLPLPSGSVIIGEYVENWHDIKPGQTYIIVSREEGVVYKRIAFKYKEEKGLKLVSDNKTYEAYWVGSEDILEVWKAKAFISTELPEPSPEPTMETLTSMMAQMQKTISAVVDNNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQF3</accession>
    <name>D7VQF3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphomethylpyrimidine kinase</fullName>
            <ecNumber evidence="2">2.7.4.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiD</name>
        <name evidence="2" type="ORF">HMPREF0766_13207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.7" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994251.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13207"/>
    <dbReference type="EnsemblBacteria" id="EFK56004">
        <property type="protein sequence ID" value="EFK56004"/>
        <property type="gene ID" value="HMPREF0766_13207"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020520_0_1_10"/>
    <dbReference type="OrthoDB" id="461201at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="1">
        <location>
            <begin position="17"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="278" mass="30157" checksum="23C2186FCA32B42E" modified="2010-10-05" version="1">MNTTYNYIPVLSIAGFDGSGGAGIQADMKTFSALGCYATSVLTALPVQNTQGVRSIYPIPDVAVREQIQTILDDIFPKAIKIGMVHTSELVQIITDTLGRYPATPVVFDPVMVATSGHKLIEESTIRTLVEQLFPITTVLTPNMDEAAILAEMDVKTLDDMYIAGEKILKLGCQSVLLKGGHLQTSMLTSLFFDQSGLVQTFEFEKFETNNTHGSGCTLSSAIASYLARGESLSEAVRLGQDYVHQAILNGKDVQTGKGNGPLNHFFNPQKLIKHELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQJ2</accession>
    <name>D7VQJ2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_13246</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994333.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13246"/>
    <dbReference type="EnsemblBacteria" id="EFK56043">
        <property type="protein sequence ID" value="EFK56043"/>
        <property type="gene ID" value="HMPREF0766_13246"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058421_6_3_10"/>
    <dbReference type="OrthoDB" id="2025630at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK56043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="133" mass="14203" checksum="CD14E210255E28A2" modified="2010-10-05" version="1">MKKSQDIGLFIVRITIAVPMLMYGISKIIHGISYIEGLLKENGLPSVLAYGVYVGEVIAPILLIAGFRTRLAAVLFASNCLTAIILAQTAAIFSLNENGGWALETLAIYAGISIALFFTGSGKIALSSTHQWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQJ6</accession>
    <name>D7VQJ6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994343.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13250"/>
    <dbReference type="EnsemblBacteria" id="EFK56047">
        <property type="protein sequence ID" value="EFK56047"/>
        <property type="gene ID" value="HMPREF0766_13250"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128738_0_0_10"/>
    <dbReference type="OrthoDB" id="1606159at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="143" mass="16644" checksum="1F13C9B11F211D6C" modified="2010-10-05" version="1">MKNRKISTIQHIARIALGLFLLFAGIGHLSFARLEFRAQVPPWVPMDVDLVVILSGIAEIGLALLILIWGQRKNWIPWFVALFFIAVFPGNIAQYTEQRDAFGLNTDGLRLFRLFMQPVLIIWALWSMDAFHKRKHNLRRQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQM8</accession>
    <name>D7VQM8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994392.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13282"/>
    <dbReference type="EnsemblBacteria" id="EFK56079">
        <property type="protein sequence ID" value="EFK56079"/>
        <property type="gene ID" value="HMPREF0766_13282"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4990">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069568_0_0_10"/>
    <dbReference type="OrthoDB" id="756899at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026935">
        <property type="entry name" value="BtrH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032369">
        <property type="entry name" value="DUF4872"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14399">
        <property type="entry name" value="BtrH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16169">
        <property type="entry name" value="DUF4872"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BtrH_N" evidence="1">
        <location>
            <begin position="12"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4872" evidence="2">
        <location>
            <begin position="152"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="325" mass="36797" checksum="03370ECDD1D7E489" modified="2010-10-05" version="1">MKLEIDPFDGQHCETTATGTLLRQLDIDLSEPLLFGLGEGLGFIFWNMKSMTFPFIGGRIKTDLLTQHIAKNLNLELTVRETASVEKAWNKVKEYLDNGKVVGLKMDCFHLQYFSRPFHFAGHYAAIYGYDDENAYLVDTQQQGGQVKTSLKSLELARAEKGPMSSRNLYYTLQKTDQKFDLKTAITAAIRNNAADYLNPPITNIGYKGILKTSTEIVKWFKTSKDIQNEFKTSAMMMEKAGTGGALFRNLYRDFLKESYGLLKIEKLNTAYESFSEIAELWTSVSQLFDKVSETADLSYILQASAILKTIADKEKKTMELLLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR08</accession>
    <name>D7VR08_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13412"/>
    <dbReference type="EnsemblBacteria" id="EFK56209">
        <property type="protein sequence ID" value="EFK56209"/>
        <property type="gene ID" value="HMPREF0766_13412"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3140829_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="49" mass="5773" checksum="C83F214624D5F658" modified="2010-10-05" version="1">MLFSKLMNYMENTNYLSLQVGVIKELQNQNQGNKKRFSNGESENLYNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRA4</accession>
    <name>D7VRA4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13508"/>
    <dbReference type="EnsemblBacteria" id="EFK56305">
        <property type="protein sequence ID" value="EFK56305"/>
        <property type="gene ID" value="HMPREF0766_13508"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109811_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="158" mass="17932" checksum="7453FA5E1B234643" modified="2010-10-05" version="1">MYKPLNINKKDIVIEAQMLVRRPVADVFTAFIDPEITRHFWFTSGSSILEKGKTVVWTWEMYGVSAEVEVLDILTNEKISVLWGEPRTHIDFLFRPVSPASTYVQIRNYGFEVLEDEQLISFLTDSTGGFTTVVDGLKVYMEQGINPGLIADKFPAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRD8</accession>
    <name>D7VRD8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994727.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13542"/>
    <dbReference type="EnsemblBacteria" id="EFK56339">
        <property type="protein sequence ID" value="EFK56339"/>
        <property type="gene ID" value="HMPREF0766_13542"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079010_1_0_10"/>
    <dbReference type="OrthoDB" id="1930882at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="acidPPc" evidence="1">
        <location>
            <begin position="120"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="246" mass="27983" checksum="88BB9E9B12DB1987" modified="2010-10-05" version="1">MVNRFWLLSIFHLICISVSAQYRQQTLSTDSTQILYNSAISKPHFQFRQLYIPGALLISGIALNGNGPESFKNEIVEERNEHIPRFRTHIDDFLQFSPILAAYSLDGLGIASKTDLYNRTAILIKGEAAMAGITYIMKKTIHQQRPDGSNYESFPSGHTAQAFAAATFLSEEYKDKFHWMPYAAYGVAASVGTFRMVNNRHYISDVLVGAAIGILSMKASYWTHHYRLTKKQKEAIAYKRYMEESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRH5</accession>
    <name>D7VRH5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994773.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13579"/>
    <dbReference type="EnsemblBacteria" id="EFK56376">
        <property type="protein sequence ID" value="EFK56376"/>
        <property type="gene ID" value="HMPREF0766_13579"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2920434_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="61" mass="6614" checksum="2233804665A9D781" modified="2010-10-05" version="1">MMNKNNKTDYISPAIISNTIDLEQSIAASSARLVPGGTGTNSANPQVEDWTTEKIDKDLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRQ8</accession>
    <name>D7VRQ8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
            <ecNumber evidence="5">3.6.3.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hmuV</name>
        <name evidence="5" type="ORF">HMPREF0766_13662</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.28" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994946.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13662"/>
    <dbReference type="EnsemblBacteria" id="EFK56459">
        <property type="protein sequence ID" value="EFK56459"/>
        <property type="gene ID" value="HMPREF0766_13662"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034543_1_0_10"/>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007845">
        <property type="entry name" value="HemS/ChuX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05171">
        <property type="entry name" value="HemS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="571" mass="64277" checksum="ABC911075B781DED" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRS9</accession>
    <name>D7VRS9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995006.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13683"/>
    <dbReference type="EnsemblBacteria" id="EFK56480">
        <property type="protein sequence ID" value="EFK56480"/>
        <property type="gene ID" value="HMPREF0766_13683"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025928_1_0_10"/>
    <dbReference type="OrthoDB" id="377914at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041662">
        <property type="entry name" value="SusD-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12771">
        <property type="entry name" value="SusD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107225" evidence="1">
        <location>
            <begin position="25"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="475" mass="53702" checksum="523F176EA4019C9A" modified="2010-10-05" version="1">MKRILKTLILFATMAMILSCSKNFEEINIDKNNPTPDKITAAILLPDVLIKLADQHVMNNYSLGNVVSQYYVRLQYNNIDIYNWVADDGVWKFYDLIPNINDIEQIAKQNNQPEYVGVALVLKALVYSMITDAYGDVPYTEAGKINAGVQMPKYDRQEDIYADLLLQLEQANTILAGAKGNIAGDPLYKGDIKQWQKFANALHLRLLSKVANRRSVVQEFTKIISNPAQYPIFGSNADNAVYQYKGSGIEVSPFTSGRGRSYEIDITGCAKPVQELLTKWKDPRLSYLYDAPKKNPSGSIVGVTPGSSMSTLPPNDQISQLSYKFFRNTQLIQGIFMTYSEQEFLLSEAVERKWISGDAKTHYDRGVKMNFEFWGLTIPAGYLSGPAAYEAGNLDLIAQQKWISYFWNGMEAWNDYKRIRRPNLVPGPANVNANRIPLRMIYPAAEQSVNQRNYQDAVKTMGGKDDINAKSWWNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS00</accession>
    <name>D7VS00_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin reductase</fullName>
            <ecNumber evidence="1">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">trxB</name>
        <name evidence="3" type="ORF">HMPREF0766_13754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995187.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13754"/>
    <dbReference type="EnsemblBacteria" id="EFK56551">
        <property type="protein sequence ID" value="EFK56551"/>
        <property type="gene ID" value="HMPREF0766_13754"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_1_10"/>
    <dbReference type="OrthoDB" id="692968at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="9"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="318" mass="34262" checksum="8A416E230FFFA904" modified="2010-10-05" version="1">MSQEREHIKCLIIGSGPAGYTAAIYAARADLKPVVYTGLVPGGQLTQTTDVDNFPGYPKGILGPELMEDLKSQAERFGTEVRFGYVTKVNLEGEIKEIEIDGSKIVTADTVIISTGATAKWLGLESEQKYNGFGVSACAVCDGFFFKNREVAIVGAGDTAAEEATYLAKLASKVHMLVRRDEFRASKAMVHRVLNTPNIEIHYNTEAVEILGDGQVVTGVKVINNQTQATTDIPVDGFFVAIGHKPNTELFTGLLDMDETGYLITKADSTQTNIEGVFACGDVQDHIYRQAITAAGTGCMAALEAERYLAAKEHAIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS32</accession>
    <name>D7VS32_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Efflux ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0766_13786</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13786"/>
    <dbReference type="EnsemblBacteria" id="EFK56583">
        <property type="protein sequence ID" value="EFK56583"/>
        <property type="gene ID" value="HMPREF0766_13786"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_2_10"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="26"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="300"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK56583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="406" mass="46024" checksum="2B0EE4EC7F9BDE5E" modified="2010-10-05" version="1">MNFPYFLAQRITFLGKRTFSKLIVRVTVSAFVLAIAAMILSVAVLRGFKDEITEKQRGFFGDILVTKQDLNSSYENTPMSLSKARMDAIRTSPNVQSIYPFATKAGIMNVNGEVEGVLLKGVDSTYDQRYLSKTIVEGDTIDFNAENGANTQILISSYFAKRMRLKLGDDFIMYFVQEPVRKRKFVVKGIFNTGSQELDKVYVVGALSLIRRLNNLDDQEAGGYEIRVRDFEKLVPTTEQVNDHLPIDLNARNIVEQMPDIFEWLNMLDMNANIIFVLMVIVAVINMISSLLISILERTSMIGILKALGFNNRGIKRVFMYNALYIIGLGLLIGNALALGLFYFQEKTRFFKLDESTYYISYVPVKIFWYDIAGLNLALIIIAMISLFVPSMLITKISPIKAIQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSC5</accession>
    <name>D7VSC5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacterial transferase hexapeptide repeat protein</fullName>
            <ecNumber evidence="3">2.3.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cat</name>
        <name evidence="3" type="ORF">HMPREF0766_13879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.28" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995486.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13879"/>
    <dbReference type="EnsemblBacteria" id="EFK56676">
        <property type="protein sequence ID" value="EFK56676"/>
        <property type="gene ID" value="HMPREF0766_13879"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_5_3_10"/>
    <dbReference type="OrthoDB" id="1878940at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008811">
        <property type="term" value="F:chloramphenicol O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="210" mass="23810" checksum="E0DAE5E714138CDC" modified="2010-10-05" version="1">MNNFFESPFKGKIIKDHITNPNIIAGKYSYYSGYYHGHSFDDCARYLFPDRKDVDKLIIGCYCSIGSGASFIMAGNQGHRYDWLSSFPFFYMPDVEHFSAGIDGFQRAGDTVIGHDVWIGSEAMIMPGIRIGDGAVIGSRALVTKDVEAYAIIGGNPAKLIKKRFSDDHISLLLEMKWWDWEDAVLKEAIPFLCSNDIDALYSYYRQRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSH4</accession>
    <name>D7VSH4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAH family protein</fullName>
            <ecNumber evidence="2">3.7.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fahA</name>
        <name evidence="2" type="ORF">HMPREF0766_13928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995579.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13928"/>
    <dbReference type="EnsemblBacteria" id="EFK56725">
        <property type="protein sequence ID" value="EFK56725"/>
        <property type="gene ID" value="HMPREF0766_13928"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_3_4_10"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="74"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="285" mass="30976" checksum="99170A45501673C0" modified="2010-10-05" version="1">MKLIRFGESGKEKIGVQIDGVNYDTSALGGDYNESFFAEDGLARLEEFVKANEGKLLEIPADSRLGAPFARPSKIVCIGLNYKDHAEETGAAIPKEPIIFMKSTTALVGPYDQVVIPKNSVKTDWEVEFGIVIGKEASYVEEAEALDYVAGYVLHNDVSEREFQIERGGTWDKGKGCDTFAPMGPYLTTADEIADINNVRLWLKVNGKTYQDGNTKNLIFSVPYIVSYVSQFMTLLPGDVISTGTPAGVGLGFNPPIYLKAGDVIELGADGLGESRQEVIAYPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSM4</accession>
    <name>D7VSM4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Antioxidant, AhpC/TSA family</fullName>
            <ecNumber evidence="5">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ccmG</name>
        <name evidence="5" type="ORF">HMPREF0766_13978</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.15" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995644.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13978"/>
    <dbReference type="EnsemblBacteria" id="EFK56775">
        <property type="protein sequence ID" value="EFK56775"/>
        <property type="gene ID" value="HMPREF0766_13978"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_1_0_10"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025380">
        <property type="entry name" value="DUF4369"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14289">
        <property type="entry name" value="DUF4369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005672220" evidence="3">
        <location>
            <begin position="20"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="238"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="378" mass="42258" checksum="E9B5D5ED9DBA34CE" modified="2010-10-05" version="1">MIKKTAIALLLSLPVLASAQSDTYLIVGKIEKPKEKSQIYLSIRNSKMQVLDSVDVKDGAFQFQGKVDGPTAVFLIYDHEHEGRKKNGAPSDALTIYVDKGQTTVHIADSIKNASVKGTAIQDQYSQYAQLLKTVNSEMNRVSAKFRNSTEEQQKDTTYSNALRNEYMKYANEKSALQENYAKNNPASYFSLQAIQDISYQDFDVVKLEGLYNKLTAEIKNTAAGQSFAQQIAAAKATTIGSSAPDFTQNDVNDKPVKLSDFKGKYVLLDFWASWCGPCRAENPNVVAAFQKYKDKNFTVLGVSLDQPGKKENWLQAIEKDQLTWTHVSDLQFWNNAAAKLYGIRSIPQNYLIGPDGKILASNLRGEELHRKLEELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSS3</accession>
    <name>D7VSS3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995757.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14027"/>
    <dbReference type="EnsemblBacteria" id="EFK56824">
        <property type="protein sequence ID" value="EFK56824"/>
        <property type="gene ID" value="HMPREF0766_14027"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_3_1_10"/>
    <dbReference type="OrthoDB" id="1087129at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="30"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="404" mass="45566" checksum="64AA61F287C098FA" modified="2010-10-05" version="1">MDLYSGLPFWIIKNALYDYNKPLQEDLKIDVAIIGSGITGSLVAHELCEAGIKCAIFDKRTVATGSTAASTAQLQYEIDVPLSQMLKDVGEKKAVQAYQSSLQSITDLENVLKQVNVKADFKRVSTIFLASNRKGRRMIGEEYDVRTQYGLPVSYLDEEQLLKEYGIEGFGALYNDQSAQMDAYAAATGILNYHHSKKELDIYSPVEIVSYQEKREGYDLKTKGGFVISCKYVIIAAGFEAGQFLPKEVMQLNSTYALVTNPIADVQFWKEKSLIWETQSPYFYMRSTADNRIMMGGEDEPFRNPKVRDLLLRKKVRKLSYKLKKMFPEIKFEVSMAWCGTFSSTKDGLPFIGAWPGKKRMLYALGYGGNGITFSMIAAQIIRNTLDGKKDDRADTFGFERLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSS4</accession>
    <name>D7VSS4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56825">
        <property type="protein sequence ID" value="EFK56825"/>
        <property type="gene ID" value="HMPREF0766_14028"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50314VV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_211076_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="48" mass="5682" checksum="FD73F3447874F089" modified="2010-10-05" version="1">MRKSIFRLLAKINKVILPKLSKKDPTKLTKFQQAILAYRYFITTRALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VST4</accession>
    <name>D7VST4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14038"/>
    <dbReference type="EnsemblBacteria" id="EFK56835">
        <property type="protein sequence ID" value="EFK56835"/>
        <property type="gene ID" value="HMPREF0766_14038"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_11_2_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="438" mass="50331" checksum="30D7DE16ECA69C4D" modified="2010-10-05" version="1">MNKSIVCLVLMMLGFPLWGSSQQLYTLEQCIVWGMENHLDVKIQNLQIKAFRAAEITTASRFLPDISARINHFYNFGSTINPQTNARESANIQSDNISVDAGINLFNFEDLNKSRISRLQTAIAQADKAVIDQEFASLLIQRYTEALAAQELKKVITHQLVNSKEQLDRIEKEVADGAKPESDIYDIQVIYTQEQKLLKQTEQDELNKKALLVQLINKEDISVANMNLIQDVPSNDNPSPSVLWENNPAVMKEQLTQQKLQQEYRQLLHQYLPTVRLNYSYGTFYATAIDQIFDTSFKFGSQLKDNRSQYLGLNLSIPIFSKGDVRRLRTRKNIDILQQQEVITKKETELKNELQNQSRKQQQYAELEATLTEASLYASKAYETTKVKYEYGKVDVSAYKAAKNQLLMARYDVLNNALSEWMTGKIIQNLLSDQYIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSU7</accession>
    <name>D7VSU7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56848">
        <property type="protein sequence ID" value="EFK56848"/>
        <property type="gene ID" value="HMPREF0766_14051"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3317182_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="39" mass="4832" checksum="8502030F9794DEDD" modified="2010-10-05" version="1">MKQKYFFNKLYQFKKFVFFVALFVKTTIDDFLQQAIITM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSV8</accession>
    <name>D7VSV8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">uppP</name>
        <name evidence="15" type="ORF">HMPREF0766_14062</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 14"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995847.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14062"/>
    <dbReference type="EnsemblBacteria" id="EFK56859">
        <property type="protein sequence ID" value="EFK56859"/>
        <property type="gene ID" value="HMPREF0766_14062"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060296_2_0_10"/>
    <dbReference type="OrthoDB" id="1826154at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00753">
        <property type="entry name" value="undec_PP_bacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFK56859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="264" mass="29113" checksum="EEEDC0E58CA4AA41" modified="2010-10-05" version="1">MNLIEVIVLAIIEGLTEFLPVSSTGHMIIATALMGIEPTPFVKLFTIVIQLGTILSVLVLYYKRFFKSLTFYYKLVVAAIPASILGLLLNDYIDQWLESPLMVAVMLVIGGIILLFVDKWFNKPSTDDSDEISYAQAFKIGLYQCLALIPGTSRSASTIVGGMTQKLTRKAAAEFSFFLALPMMFGASAVKLLKFFKEGNTFTGEEINLLIIGNVVGFIVAIIAIKSFIGILTKYGFKAFGWYRIIIGMIIIIMLLTGHSLQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSZ2</accession>
    <name>D7VSZ2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995893.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14096"/>
    <dbReference type="EnsemblBacteria" id="EFK56893">
        <property type="protein sequence ID" value="EFK56893"/>
        <property type="gene ID" value="HMPREF0766_14096"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1320230_0_0_10"/>
    <dbReference type="OrthoDB" id="1869510at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="208" mass="23948" checksum="84AF77391AB311C5" modified="2010-10-05" version="1">MKNLLFVLGAVLLLLSCKKEEVYSPWKFKNGQVVELQVSHKYASTDNQLLLLPGKEPIDISLYDFTEREPGYIYKIKAKMVGLKEPPSDGSSYYLEFMKVLNKEKYNGNETFTIPLIRSFIPGGPHIEIRKKDDKYYFEGEKLILKPLNTEAAGELATLWQEQLDLEAQWKANQSAVPKWHMVTARVKHDPENFGKAYIVEKLTFTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT50</accession>
    <name>D7VT50_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996037.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14154"/>
    <dbReference type="EnsemblBacteria" id="EFK56951">
        <property type="protein sequence ID" value="EFK56951"/>
        <property type="gene ID" value="HMPREF0766_14154"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8XW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109688_1_0_10"/>
    <dbReference type="OrthoDB" id="1745756at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045788">
        <property type="entry name" value="MobC_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19514">
        <property type="entry name" value="MobC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="148" mass="17538" checksum="62779C741252D8B2" modified="2010-10-05" version="1">MNENNKRQVRKPIGRPLKTDPAIFRYSLSLNEEENAKFLALFDQSNMDVKAHFIKSRIFDKTIKTIQIDKGTVDFYMRLTSFHSQFRNVGVNYNQIIKLLYKNFSQKKASAYLFKLEKQTAEMAMLCRKIIELTEEFEAKYLKNHSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTB4</accession>
    <name>D7VTB4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphonate catabolism associated alcohol dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">adh2</name>
        <name evidence="2" type="ORF">HMPREF0766_14218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996205.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14218"/>
    <dbReference type="EnsemblBacteria" id="EFK57015">
        <property type="protein sequence ID" value="EFK57015"/>
        <property type="gene ID" value="HMPREF0766_14218"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_10"/>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="12"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="359" mass="39253" checksum="030039D1C81F0F8C" modified="2010-10-05" version="1">MIKQGNFLVFEQSNAPLALHSLPVRSLSKGEILVKICYTTLCGSDLHTYCGMRQEPCPTILGHEIVGVIEDIAPDYKAADAIGIALQKGDLVTWTVFASDPQTNSYNPDIPQKNIPLYKYGHRQLTEADSFHGGLATHIILRPHTCIRKLSASLPLPVAATINCAVATAAGAIRLAGSVKGKRILISGMGLLGLVCAAMCKEAGAACIIVSDMDQNRLELARQFGADQTFSPTNQSEEMTNSLLVDCFFDMSGSPEAMESGIDHLTVGGYAVLIGAVFKQRKLHIDAEQIIRRILTIRGLHNYNYSDFNTAVDFITDNLNKYPFARLIEKEFSLEEVNEAFAYAIDKKPVRVGILIHQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTC2</accession>
    <name>D7VTC2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative mannose-6-phosphate isomerase, class I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996229.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14226"/>
    <dbReference type="EnsemblBacteria" id="EFK57023">
        <property type="protein sequence ID" value="EFK57023"/>
        <property type="gene ID" value="HMPREF0766_14226"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1482">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_466831_0_0_10"/>
    <dbReference type="OrthoDB" id="645703at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="578" mass="66258" checksum="FE137995EE99AABE" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTG7</accession>
    <name>D7VTG7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996350.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14271"/>
    <dbReference type="EnsemblBacteria" id="EFK57068">
        <property type="protein sequence ID" value="EFK57068"/>
        <property type="gene ID" value="HMPREF0766_14271"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086407_4_1_10"/>
    <dbReference type="OrthoDB" id="1515383at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822">
        <property type="entry name" value="PTHR34822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="197" mass="23312" checksum="1659FFB91242B343" modified="2010-10-05" version="1">MKVTFEKYNPLWTASFASLETELKTYLSDFDVRIEHIGSTSVKNLSAKPIIDIMIGVKDPEDLDKIPDLLMAEDYIYYENYNADMPYRRFFVRLHQSPGSLGLPVHITSIADVTEELHNHTWRMAHIHVIPLASEHWIRHIAFRDYLRNHSVVREEYQQLKEKLSKQEWIDGNDYNAAKDSFLKREEQKAIQWYNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTH1</accession>
    <name>D7VTH1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996365.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14275"/>
    <dbReference type="EnsemblBacteria" id="EFK57072">
        <property type="protein sequence ID" value="EFK57072"/>
        <property type="gene ID" value="HMPREF0766_14275"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4709">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1371471_0_0_10"/>
    <dbReference type="OrthoDB" id="1863209at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="199" mass="23161" checksum="A07991E210E6E3E8" modified="2010-10-05" version="1">MKFKEIAFKDKNSKRIYLDYISRIQQATKSLDKTNQQEVLLEINSHIYESITDPAAMEKGEVERLLDVLEKLGQPEIFLKPLVAEKKLEEATRSFNPFHILKALILNIGNGISYVIFTLLYLLLFGFIFLIGAKLVDPENVGFFFKPNEIFILGYYRENGISYLQYEQLGHWFIPAMLLLAIILYVLITLLLRLKRILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTJ6</accession>
    <name>D7VTJ6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase-like monooxygenase</fullName>
            <ecNumber evidence="2">1.14.14.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.3" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996406.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14300"/>
    <dbReference type="EnsemblBacteria" id="EFK57097">
        <property type="protein sequence ID" value="EFK57097"/>
        <property type="gene ID" value="HMPREF0766_14300"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_2_1_10"/>
    <dbReference type="OrthoDB" id="1427241at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047646">
        <property type="term" value="F:alkanal monooxygenase (FMN-linked) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="340" mass="37881" checksum="ED94A7F809E29FAC" modified="2010-10-05" version="1">MKKIGFLSFGHWANHPAYSTQTASDTLLQSIDLAVAAEELGIDGAYFRVHHFAKQLASPFPLLSAIGARTSRIEIGTGVIDMRYENPLYMVEDAGAADLISGGRLQLGISRGSPEQVIDGWRYFGYALSEGETDADMGRRKALEFLERLQGVGFAEPNPYPMFPNPPGLLRLEPHSEGLRDRIWWGAASNATAVWAAQNGMLLQSSTLKYDESGKPFHVQQAEQIRLYKEAWKEAGHTREPRVSVSRSIFALVNDQDRYYFGHEADRDDKIGMIEADKRAIFGRSYAAEPDQLIRELAQDEAIQEADTLLLTIPNTLGVEYNVHVLSSFLEHVAPGLGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTU1</accession>
    <name>D7VTU1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002238.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14411"/>
    <dbReference type="EnsemblBacteria" id="EFK55720">
        <property type="protein sequence ID" value="EFK55720"/>
        <property type="gene ID" value="HMPREF0766_14411"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096111_1_0_10"/>
    <dbReference type="OrthoDB" id="1594801at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="2">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK55720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="209" mass="22920" checksum="A86D13DEF7483C94" modified="2010-10-05" version="1">MKKINLDIVGLSYSQTQSGAYALVLGEVGGNRRLPIIIGGFEAQAIAVEIEKMTPSRPLTHDLFKAFADAYAITLQEVIIYNLIDGIFFAKLICSDGEKISEIDARTSDAIALAVRFDAPIFTYEFIMASAGIVIESNDFAFLENIESVEAAKAPQEPRKEIPTPQKKSPYSSLSDEQLEAALEKAIADEQYETAAAIRDEITYRKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGH1</accession>
    <name>D7VGH1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10090"/>
    <dbReference type="EnsemblBacteria" id="EFK60146">
        <property type="protein sequence ID" value="EFK60146"/>
        <property type="gene ID" value="HMPREF0766_10090"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033R66">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_414413_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK60146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="662" mass="77373" checksum="E732A513132DA28E" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGJ0</accession>
    <name>D7VGJ0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">aspS</name>
        <name evidence="9" type="ORF">HMPREF0766_10109</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996595.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10109"/>
    <dbReference type="EnsemblBacteria" id="EFK59192">
        <property type="protein sequence ID" value="EFK59192"/>
        <property type="gene ID" value="HMPREF0766_10109"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014330_3_2_10"/>
    <dbReference type="OrthoDB" id="226836at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="142"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="7">
        <location>
            <begin position="197"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="530"/>
            <end position="533"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="587" mass="66452" checksum="EAFFE8592337376D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGN5</accession>
    <name>D7VGN5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996742.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10154"/>
    <dbReference type="EnsemblBacteria" id="EFK59237">
        <property type="protein sequence ID" value="EFK59237"/>
        <property type="gene ID" value="HMPREF0766_10154"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZPVQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1730234_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106922" evidence="1">
        <location>
            <begin position="20"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="151" mass="17186" checksum="0C7643D4D6D99578" modified="2010-10-05" version="1">MRKWIATVLVLIYSLTSSGAAFYFHICGNDQEHIISVSDKSSHKNCPLCIKKSSSQASKKSSSCHTDAKPDKKHVCKDVVVDLEKASDNHYSNNNQIKNFNLFTPSVITLFWVYNFNIFEELAVEHQIAQTNSTALVRQQDSYLLHCNFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGS2</accession>
    <name>D7VGS2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase, S41 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10191</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996825.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10191"/>
    <dbReference type="EnsemblBacteria" id="EFK59274">
        <property type="protein sequence ID" value="EFK59274"/>
        <property type="gene ID" value="HMPREF0766_10191"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031949_1_0_10"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107088" evidence="2">
        <location>
            <begin position="20"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="111"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="503" mass="56455" checksum="E4065E87F6DD7F13" modified="2010-10-05" version="1">MKRLFPVLLILLLFTSVYSCKKSDNPDNKNDTEEDMIKDSVFYYTKVLSLWEGSMPPGNVNTLDDKGVVRSYTKKYATGEEVLKYMMSLTPVVNGSPVDRYSFIDRQGTISGEIEEGVSTSYGMYVFYLQTSSSGDNADLYVRMVDKNSPAYQAGIRRGDRILSINGQTNIDYKTQQAQSFKLINDALNSKSMTIKFVSQTSVTTEKQIVSSLYNFDPILASKVIEQNGKKIGYLAFSSFVAIYNNRIPTAMLSSFENIFSQFEGQNISELIVDLRYNGGGSVETAEYLANRIVPASATGKRMYSYKLNRNLQAWGWAKEGGEFGPVNYAKKGTLNLNKVYFLVTESTASASELLINSLKPYFKDNQKMIGTYGADSRGNRVVENTYGKPVGFFRTSIPNTDVDLYATSFQTINADNYGDYFAGLTPDGSTYEDYFKDFGDPQEGMIAEALYYSLNGSWLSSTSKTALASVNKLRNEKYISRHRIDTRAHANGMYKFQTRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGW3</accession>
    <name>D7VGW3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996941.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10232"/>
    <dbReference type="EnsemblBacteria" id="EFK59315">
        <property type="protein sequence ID" value="EFK59315"/>
        <property type="gene ID" value="HMPREF0766_10232"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_7_1_10"/>
    <dbReference type="OrthoDB" id="2056793at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="274"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="374"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="462" mass="51622" checksum="E74DB36CD7C16489" modified="2010-10-05" version="1">MFFERIYDESLAQASYMIGCQAKGVALVIDPKRDVDTYLEIAKRNNLKITQITETHIHADFLSGSRELAELTGATLYLSDEGGEDWQYEFPHEGLKEGDKLLVGNLTLTVIHTPGHTPESISFVLTDHPASDQPIMVFTGDFVFVGDVGRPDLLEKAAGITGTKEVGAKDMFRSIQKFLTLPDFVQLWPGHGAGSSCGKALGSVPSSTLGYERIRNWALQDQKEDKFVTELLDGQPEPPAYFAMMKKLNKVDRPLLLHVPEIPLLNKEQFLKYKQDDVTIVDTRPKELFVKGHIPQSINIQHKKSFATWAGWLLQYDKPFILVAAPHEIEELTRKLMRIGLDNVLGYITDIDDLGIPLEMTKVVDLAAVKSAINNPDIQLIDVRNTNEYQSGHIKGAISLMWGKLEKNLSAIDSQKTKLIYCQGGDRASIAASLLKKKGIEHVEVYLGSMNEWLSQGQEVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGZ7</accession>
    <name>D7VGZ7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative alpha-1,2-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_10266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997038.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10266"/>
    <dbReference type="EnsemblBacteria" id="EFK59349">
        <property type="protein sequence ID" value="EFK59349"/>
        <property type="gene ID" value="HMPREF0766_10266"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003690_2_2_10"/>
    <dbReference type="OrthoDB" id="100818at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="Alpha_mannosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107191" evidence="2">
        <location>
            <begin position="26"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92N" evidence="4">
        <location>
            <begin position="31"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92" evidence="3">
        <location>
            <begin position="278"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="761" mass="85219" checksum="808811D1C9047414" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH48</accession>
    <name>D7VH48_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997157.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10317"/>
    <dbReference type="EnsemblBacteria" id="EFK59400">
        <property type="protein sequence ID" value="EFK59400"/>
        <property type="gene ID" value="HMPREF0766_10317"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9BT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056540_0_0_10"/>
    <dbReference type="OrthoDB" id="1268304at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107464" evidence="2">
        <location>
            <begin position="21"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="406" mass="45697" checksum="50AFD937C3503844" modified="2010-10-05" version="1">MKRIVSIFLCSLFAVIQVYGQQYSATLEGNKKEGYYQFKIPSGIRSVIGNDISKIRIRDNGGQEVPFVKFVYASAGDKFIPLTIVKREIIADSVTTLVIKNIKLETWTSISLRIANSNSSKRYTLTGSNDSVNWFSLSENQLLENLAGSDQTFNDQEITFPLNNYRYLKIMIRDKGSSPINVLEAGRYESVMTAATYQPVHAVKFDMKSEKKNSILHVMLPDFQIIDYVSLSVADPKLYQRKVSVLANQLVQVKRNRWEDQLVEIGQYELSPANTHMIVPSLFVKDFYIQIENLDSPPLRIDSLSLGQTALNIVTNLAAGKQYSIVIDSAYKAPDYDLSLFKNKANDQLPVLTVSKLKSIKPGSGDIKNEAWKKTFGNILLWGGMVIAIIVICYFAIGFLKDVNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH50</accession>
    <name>D7VH50_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ricin-type beta-trefoil lectin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_10319</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997161.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10319"/>
    <dbReference type="EnsemblBacteria" id="EFK59402">
        <property type="protein sequence ID" value="EFK59402"/>
        <property type="gene ID" value="HMPREF0766_10319"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016031_8_4_10"/>
    <dbReference type="OrthoDB" id="593041at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B-type lectin" evidence="5">
        <location>
            <begin position="541"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK59402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="649" mass="69791" checksum="F5833A2412F88EFA" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH72</accession>
    <name>D7VH72_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PPIC-type PPIASE domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10341</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997205.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10341"/>
    <dbReference type="EnsemblBacteria" id="EFK59424">
        <property type="protein sequence ID" value="EFK59424"/>
        <property type="gene ID" value="HMPREF0766_10341"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023843_0_1_10"/>
    <dbReference type="OrthoDB" id="1201303at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023058">
        <property type="entry name" value="PPIase_PpiC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13145">
        <property type="entry name" value="Rotamase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01096">
        <property type="entry name" value="PPIC_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="3">
        <location>
            <begin position="345"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="703" mass="76806" checksum="D55A4A22F24C0BB2" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHF9</accession>
    <name>D7VHF9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">asnC2</name>
        <name evidence="5" type="ORF">HMPREF0766_10428</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997421.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK59511">
        <property type="protein sequence ID" value="EFK59511"/>
        <property type="gene ID" value="HMPREF0766_10428"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_0_10"/>
    <dbReference type="OrthoDB" id="1844486at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="157" mass="17807" checksum="42FF9482D4F01BE8" modified="2010-10-05" version="1">MENNYSNYDLDTLDIQILSILMEDASIPYTEIAKKLIVSGGTIHVRMKKMEELGIIRGSNLIINPQKVGFDITAFLGIYLDKGSQYADAVEQLKKIKEVVELHYCTGQYSIFAKIICRDTGHLRKVLNEDIQSVKGIQRTETIISLEESIKRQISLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHG9</accession>
    <name>D7VHG9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpsM</name>
        <name evidence="8" type="ORF">HMPREF0766_10438</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997453.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10438"/>
    <dbReference type="EnsemblBacteria" id="EFK59521">
        <property type="protein sequence ID" value="EFK59521"/>
        <property type="gene ID" value="HMPREF0766_10438"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_1_2_10"/>
    <dbReference type="OrthoDB" id="1772647at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="125" mass="14166" checksum="924B6F7997901E87" modified="2010-10-05" version="1">MARIAGIDLPKNKRGVIGLTYIFGIGRQTAAYILDKAGISEDVKVQDWNDDQLAAIRTIINDELKVEGALRSEVQLNIKRLMDIGCYRGLRHRKHLPVRGQRTKNNTRTRKGKRKTVANKKKATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHP7</accession>
    <name>D7VHP7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pcrR</name>
        <name evidence="3" type="ORF">HMPREF0766_10516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997607.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10516"/>
    <dbReference type="EnsemblBacteria" id="EFK59599">
        <property type="protein sequence ID" value="EFK59599"/>
        <property type="gene ID" value="HMPREF0766_10516"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052345_4_0_10"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="222"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="320" mass="37456" checksum="896A1703A67E5A30" modified="2010-10-05" version="1">MVIKAKIKEHNEWLFWEELPEHPLAQTAISEKHIAINKFPIDISTYQILSRGIFILQADMRFAQQSKIISEIDSEAIVSQFILSKNDSGRGYTFSKHNIRYIPSLYEEHEVEPGQQFLYFLLIMTPEFYNNLVTIPSPLHALFKERMKSKTVTSIVEDDLFATAEMIKIIEDLRTTTTKNELKQIFVNARVLELIMLQFEQFNHVGGKLDDSLRAEDIQKLEEVLRILRNQFVSPPTHKQLSKLVLLNEFKLRNGFKQHFGTTIYNYITRIRMEEAKRLIIQEQKNMYEVGIKVGFKHQASFTHAFKKYYGILPSELVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHU5</accession>
    <name>D7VHU5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10564"/>
    <dbReference type="EnsemblBacteria" id="EFK59647">
        <property type="protein sequence ID" value="EFK59647"/>
        <property type="gene ID" value="HMPREF0766_10564"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3084857_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="52" mass="6196" checksum="C0D5EC259C58624D" modified="2010-10-05" version="1">MFDVIFYFFYRIYNGLPKDIDPETSASLALGACIGLFYNQNCKYNIIYFFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHU8</accession>
    <name>D7VHU8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase core domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10567"/>
    <dbReference type="EnsemblBacteria" id="EFK59650">
        <property type="protein sequence ID" value="EFK59650"/>
        <property type="gene ID" value="HMPREF0766_10567"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_31_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="111"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="267" mass="31284" checksum="B1A8B689D969E045" modified="2010-10-05" version="1">MKKALKLCERKELVDGEMKEQGISIHRACKIVCMSRSMYYYVHKKNDQTVISKLMDLAARYPSRGFQTYYGKIRLEGLLWNRKRVLRVYRSINLKLRIKRKRCIPPRIKEKLLVPGSVNETWSIDFMSDSLANGRRFRVLNVIDDYNRESLINEAFYSIPGGRLVQKIKELIIDRSTPKRIRTDNGPEFLSKVFTDFCTENGIELQYIQPGKPAQNAYIERLNRTFREDVLDAYLFDSLTEVNAIAYEWQIDYNENHPDTALNGLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHZ2</accession>
    <name>D7VHZ2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Redoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_10611</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997853.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10611"/>
    <dbReference type="EnsemblBacteria" id="EFK59694">
        <property type="protein sequence ID" value="EFK59694"/>
        <property type="gene ID" value="HMPREF0766_10611"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_11_0_10"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="41"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="192" mass="21646" checksum="B0C26ACEDC0CA4F9" modified="2010-10-05" version="1">MNKKTFHIILGIMTFLVLITGISLYALGNQINELKTDSNPLTESGYADSKTETQTIGKTDAVFKNVKGEKIVLKDIRNKVIFINMWATWCPPCKKEMPSLNNLYNKLKSNPNIVFIMMDVDGKLKQSTSYIKEKGFSLPNYIVEGNLPEEFSTNSIPTTIIIDKSGKMVTKHIGAVDFDHPEMLPFIQNLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI08</accession>
    <name>D7VI08_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10627</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10627"/>
    <dbReference type="EnsemblBacteria" id="EFK59710">
        <property type="protein sequence ID" value="EFK59710"/>
        <property type="gene ID" value="HMPREF0766_10627"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027579_2_2_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010723">
        <property type="entry name" value="HemN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06969">
        <property type="entry name" value="HemN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="347" mass="39187" checksum="C433773428DB84E3" modified="2010-10-05" version="1">MMAAMRQELELRSQSGDTKKLTSLYFGGGTPSILDAGHIQSFIDAVSEYYDIAEDAEITLEANPDDLDHKKVQQLRHTDINRFSIGIQSFYEEDLSWMNRAHNASEADAAIKRVQDAGFENITADLIYGYPLLTDQKWNANINKLLEFEIPHISAYSMTVEPQTALDHFIKKGKSPAMNESQSAAQFEILIDKLVNSGFEHYEISNFAKPDRYARHNSSYWKGDTYIGIGPSAHSFNGDNRSWNIANNALYIKGISEKTPVAEVEQLSFENKVNEYIMTSLRTMWGMDTAKIEEAFGSDTLNQLTNTIQPFIAQGEVRLQDGHYYLTAKGKLIADHIASELFLEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI27</accession>
    <name>D7VI27_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997923.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10646"/>
    <dbReference type="EnsemblBacteria" id="EFK59729">
        <property type="protein sequence ID" value="EFK59729"/>
        <property type="gene ID" value="HMPREF0766_10646"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_323582_0_0_10"/>
    <dbReference type="OrthoDB" id="96337at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106975" evidence="1">
        <location>
            <begin position="19"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M14" evidence="2">
        <location>
            <begin position="38"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="837" mass="94960" checksum="E5AEB399C6766B15" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIJ7</accession>
    <name>D7VIJ7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase, S54 family</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_10816</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998257.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10816"/>
    <dbReference type="EnsemblBacteria" id="EFK59899">
        <property type="protein sequence ID" value="EFK59899"/>
        <property type="gene ID" value="HMPREF0766_10816"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1255304_0_0_10"/>
    <dbReference type="OrthoDB" id="2053476at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="52"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="220" mass="25205" checksum="BAF49DED8C412AB2" modified="2010-10-05" version="1">MPAIFDILPTPAESPWSYTLVPVIIICSIIGFYYKPFFYKLLLHPYEICRGKRWHTLFTSALVHRSWIHLLVNVVLIYALLYDLFGLIKQEYGTNAAYLLSILIILCLVVIPNLFQTYIKKDDFTYTAVGASGLTFGLYGFSFLYFPLQKMSSFWIEAIKVSAQFWLAVLIVILLLSFVPKSKVNKGLHIFAFLLGSVLAFCVRPPAFLEFVNSFKSIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIW1</accession>
    <name>D7VIW1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">dnaA</name>
        <name evidence="13" type="ORF">HMPREF0766_10930</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the DnaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998498.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10930"/>
    <dbReference type="EnsemblBacteria" id="EFK60013">
        <property type="protein sequence ID" value="EFK60013"/>
        <property type="gene ID" value="HMPREF0766_10930"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0593">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026910_3_0_10"/>
    <dbReference type="OrthoDB" id="219876at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024633">
        <property type="entry name" value="DnaA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11638">
        <property type="entry name" value="DnaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="11">
        <location>
            <begin position="171"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="12">
        <location>
            <begin position="382"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="179"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFK60013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="475" mass="54171" checksum="89C3EB9ACDCE6928" modified="2010-10-05" version="1">MEKTYTSVWNSCLQIIKDNIPAQSFKTWFEPVKAVKLDENVLTIQVPSLFFYEWLEEHYVGILRKTVKKFLGEQGRLEYNIVVEKSSTNIPYTTNIPSNGNGAEGKRQSIPVPVNLNKNIKNPFVIPGLKKLQVDPQLNQHYTFDNFIEGECNRLARSAGFAVANKPGGTSFNPLMLYGDVGLGKTHLSQAIGNEIKRNLPDKLVIYVSCEKFCQQFVDSLKNNTINDFVNFYQAMDVIIMDDVHNFAGKEKTQDIFFHIFNHLHQSGKQIILTSDKAPKDLAGLEERLLSRFKWGLSADIQVPDLETRMAILKKKMYSDGIELPENVVEYVAHQIDNSVRELEGAMVSLLAQSTLNKKEIDLNLAKSMLKNFVKNTSKEISMEYIQKLVCEYFEVPVEMVKSKVRKREIVQARQISMYLAKNHTKSSLKSIGNFFGGRDHSTVIYACQTVEDLIETDKKFKTYVQDILKKLKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIY4</accession>
    <name>D7VIY4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">gcvH</name>
        <name evidence="6" type="ORF">HMPREF0766_10953</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998541.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10953"/>
    <dbReference type="EnsemblBacteria" id="EFK60036">
        <property type="protein sequence ID" value="EFK60036"/>
        <property type="gene ID" value="HMPREF0766_10953"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097408_2_2_10"/>
    <dbReference type="OrthoDB" id="1773485at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="22"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK60036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="126" mass="13772" checksum="0873D3640537EA5F" modified="2010-10-05" version="1">MNFPAELKYTKDHEWVRVEGDEAVIGITDFAQRELGDIVFVDINTVGEEVPANEVFGTVEAVKTVSDLFMPVTATVLAVNEAIDASPELVNSDAYGEGWIIRVKLSNPADVDALLSADQYKEEINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ50</accession>
    <name>D7VJ50_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">ppa</name>
        <name evidence="6" type="ORF">HMPREF0766_11019</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002176.1">
        <property type="nucleotide sequence ID" value="NZ_GL379779.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11019"/>
    <dbReference type="EnsemblBacteria" id="EFK59185">
        <property type="protein sequence ID" value="EFK59185"/>
        <property type="gene ID" value="HMPREF0766_11019"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073198_1_2_10"/>
    <dbReference type="OrthoDB" id="1767807at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK59185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="180" mass="20158" checksum="A033E7432709C767" modified="2010-10-05" version="1">MSTQNPWHQVSPGSNMPESVNAIIEISNGSKGKYELDKESGLLILDRVMSSAVTYPANYGFIPQTYCDDKDPLDILVICSVDIMPMSLVEAKIIGVMNMVDGGEQDDKIIAVAKNDPVMNYINNIEELPPHTMKEIVQFFETYKALENKQVVVEGVQGREKAQEILLESLELYKQTFVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ78</accession>
    <name>D7VJ78_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter, MotA/TolQ/ExbB proton channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0766_11047</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000423.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11047"/>
    <dbReference type="EnsemblBacteria" id="EFK58931">
        <property type="protein sequence ID" value="EFK58931"/>
        <property type="gene ID" value="HMPREF0766_11047"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0811">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053325_4_0_10"/>
    <dbReference type="OrthoDB" id="1796180at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="8">
        <location>
            <begin position="98"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK58931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="233" mass="25247" checksum="6113B2C1CE756837" modified="2010-10-05" version="1">MSLIQDTALALDSLGQAAQQPIQMATQEETNLIQLLMKGGWIMWPIAFLFFLGLVIFLERYITIRKASKFDNGLMSQIKSNVMSGKLDAAVAVCRSSNTPLSRMLQKGLLRVGRPIKDIEGAIENIGKIEVSKLEKNINILGIIAGIAPMLGFVGTIFGVIQIFRDVEAVGGIDIGSVSGGLYVKMISSASGLTVGILAYIGYHALNMMVERLILRMETDAVEFIDLLDEPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJF8</accession>
    <name>D7VJF8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative monovalent cation/H+ antiporter subunit C</fullName>
            <ecNumber evidence="6">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mnhC</name>
        <name evidence="6" type="ORF">HMPREF0766_11127</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.5" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000619.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11127"/>
    <dbReference type="EnsemblBacteria" id="EFK59011">
        <property type="protein sequence ID" value="EFK59011"/>
        <property type="gene ID" value="HMPREF0766_11127"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082058_3_1_10"/>
    <dbReference type="OrthoDB" id="2078994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK59011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="118" mass="12897" checksum="D379F58BA2D61619" modified="2010-10-05" version="1">MELILVVLIGLLYAAGVYMILRRSMVKLLLGIMLLGNGTNILIFLLGNITKGKPPVIDPDLSIFNDIYADPIPQALILTAIVISFGLTAFAIVLLKRVYALINSDDLDDLNTPEEDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJL9</accession>
    <name>D7VJL9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDSL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11188"/>
    <dbReference type="EnsemblBacteria" id="EFK59072">
        <property type="protein sequence ID" value="EFK59072"/>
        <property type="gene ID" value="HMPREF0766_11188"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065859_0_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01821">
        <property type="entry name" value="Rhamnogalacturan_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PTHR43695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="16"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="246" mass="27715" checksum="B65D565AFB1F7594" modified="2010-10-05" version="1">MAVSFTAPQRRPVIFLIGDSTVKNGKGKGDAGQWGWGSVLEQYFDTTRIDIQNRALGGTSTRTFISKGLWRNVLDQLNKDDYLVVQFGHNDGGPLDDTARARGTIKGIGDEVKTIYNPLLRQEETVHTYGWYLTKMIQEAKQKGAHVIICSPIPRDRWKDHKVERAEGSYPAWAEQVAQNNKVPFIDLHNLVADEYDKIGKEKVAAYFTAADHTHTSYEGAQKNAQIVVQAIKELNQTELRNYLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJQ3</accession>
    <name>D7VJQ3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="5 10">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">nrdE</name>
        <name evidence="12" type="ORF">HMPREF0766_11222</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="5 10"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000818.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11222"/>
    <dbReference type="EnsemblBacteria" id="EFK59106">
        <property type="protein sequence ID" value="EFK59106"/>
        <property type="gene ID" value="HMPREF0766_11222"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000404_4_1_10"/>
    <dbReference type="OrthoDB" id="357568at2"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026459">
        <property type="entry name" value="RNR_1b_NrdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013554">
        <property type="entry name" value="RNR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08343">
        <property type="entry name" value="RNR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04170">
        <property type="entry name" value="RNR_1b_NrdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIBORED_LARGE" evidence="11">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK59106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="701" mass="80651" checksum="7C3D6F2E2E23155C" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJR9</accession>
    <name>D7VJR9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nicotinamide mononucleotide transporter PnuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pnuC</name>
        <name evidence="7" type="ORF">HMPREF0766_11238</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000865.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11238"/>
    <dbReference type="EnsemblBacteria" id="EFK59122">
        <property type="protein sequence ID" value="EFK59122"/>
        <property type="gene ID" value="HMPREF0766_11238"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076589_2_0_10"/>
    <dbReference type="OrthoDB" id="1301128at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006419">
        <property type="entry name" value="NMN_transpt_PnuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36122">
        <property type="entry name" value="PTHR36122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04973">
        <property type="entry name" value="NMN_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01528">
        <property type="entry name" value="NMN_trans_PnuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="199" mass="23356" checksum="5220C24231D09FA1" modified="2010-10-05" version="1">MQDFFQQIARQFVQTSLLEWIGTITGFLCVYLAARQHILNWPVSIISVTIYAYLFYHSKLYGDAVLQIYFLGTAVYGWYYWIKRKKEADKPIVSFTNRQMVWTIGIILLLTAALGTFLDHQTNSDVPYIDGFCTAVSFVAQFLMTRKVLQNWLLWVFVDICYIPLYYHKDLLLTAVLYLAFAVIAWNGYKDWKKTYLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJU1</accession>
    <name>D7VJU1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998625.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11260"/>
    <dbReference type="EnsemblBacteria" id="EFK58543">
        <property type="protein sequence ID" value="EFK58543"/>
        <property type="gene ID" value="HMPREF0766_11260"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZB72">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052483_0_0_10"/>
    <dbReference type="OrthoDB" id="1619451at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="418" mass="46934" checksum="6CE0B7432D875B88" modified="2010-10-05" version="1">MLKAAALHLAIVISLIITLILGSMLYLAFFFRDQTARFNRYDLLQQELEAGITIMQTLDFPYTAKDSILHSVLYSGDSISVSKQQWGLFDIGYVRSYIQKDTLQKTFMMGIPLQDSLVLYVADEDRPISVSGKTSIIGNVQLPKAGIQPAYVDGKYYSGHKDIVQGKKKDSERQLPKLQQKRLNHILELYGLLENEDLPSIPSGNLRESFYQPAAQYRSMEALSLTADSISGHVILVVDSTLHISANSVIHDAIIVARSISIEKGFKGSAQFFALDSIIVEDEVNLQFPSVLGIVKSPKEDLQPLIRIGKKCHIEGTVFYYEDKRSPVPAVVSVGKESIISGDMLVYGMLQYEKPVQFIGTTYCYRFLVRTPASIYENFLIDLTLDRKKLSPYHLRSFLWDPSQKTVSASLLQSLNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK08</accession>
    <name>D7VK08_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998812.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11327"/>
    <dbReference type="EnsemblBacteria" id="EFK58610">
        <property type="protein sequence ID" value="EFK58610"/>
        <property type="gene ID" value="HMPREF0766_11327"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_767043_0_0_10"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="250"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="371" mass="43481" checksum="601D0F455569A2F5" modified="2010-10-05" version="1">MGIMIYIVYTILMALCLLSLHLIYSLRERRAFDWVGAGFLMVTGIHVIHNSLFRSTYVDHVLMFKIAPFEFLYGPLLYLLCIISDTKKISYWHLFHFVPFGLACLCYFFILFSAQKTFLNIFYDLHDYIVAFSWLIYSIAIWIHMALHQDSRQYRSKGLYWIATAGGLSALTVLVIDVFDADDKSKMLLTNLSNLLMFVPVLITVSFLYLYYFKLLFLKTSVKDKKPADEEYLSYKSSSLNTAQMEAYAMKITKYLRTEKYLDITFSLEILSRHTHIPKHHLSQVFTRYFKCNFTKHINMLRIDYACRILEQQDFAENVDNLVEKCGFKSKASFYRNFNLLRGCTPLEYRQSRIVCQPGSESSHSYIGKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKM0</accession>
    <name>D7VKM0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999376.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11539"/>
    <dbReference type="EnsemblBacteria" id="EFK58822">
        <property type="protein sequence ID" value="EFK58822"/>
        <property type="gene ID" value="HMPREF0766_11539"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032ZJN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2059915_0_0_10"/>
    <dbReference type="OrthoDB" id="1818934at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="110" mass="12763" checksum="D959508726B629DC" modified="2010-10-05" version="1">METKVIKTIREWLPQVIHEQICDDYTALQSLAGYFLQHIHGDEDQQAMAIEAAQIVNILYLNGKLHDKNAIENEFLSIIANEETPKSLKKHLAFFPKELRQVYLKTIIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKP9</accession>
    <name>D7VKP9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_11568</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Skp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999434.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11568"/>
    <dbReference type="EnsemblBacteria" id="EFK58851">
        <property type="protein sequence ID" value="EFK58851"/>
        <property type="gene ID" value="HMPREF0766_11568"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053320_3_0_10"/>
    <dbReference type="OrthoDB" id="1548641at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.910.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005632">
        <property type="entry name" value="Chaperone_Skp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024930">
        <property type="entry name" value="Skp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35089">
        <property type="entry name" value="PTHR35089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03938">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00935">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111384">
        <property type="entry name" value="SSF111384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005672226" evidence="4">
        <location>
            <begin position="24"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="67"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="190" mass="20933" checksum="A5932B49B1277277" modified="2010-10-05" version="1">MKNLVKSAALAAGLLFSTQLVNAQQKIGHINFGEIISGTTEFKAAQDQLKTLNDSKTKELQGMYAEYQKKQTDANEKMRNRSEANKETVDAELNKLGTELRDIETRINEVQRLAQEEVGKKQEELYQPIERKVMNAVNDIAKAKGYAYVFDISSTNIPYFAGGDDLTTDVKSKLGISATAAPAATTPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKV4</accession>
    <name>D7VKV4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999531.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK58906">
        <property type="protein sequence ID" value="EFK58906"/>
        <property type="gene ID" value="HMPREF0766_11623"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097934_3_0_10"/>
    <dbReference type="OrthoDB" id="1654302at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11530">
        <property type="entry name" value="NTP-PPase_DR2231_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033653">
        <property type="entry name" value="NTP-PPase_DR2231-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023292">
        <property type="entry name" value="NTP_PyroPHydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="156" mass="17881" checksum="8BDDF0D9160372CE" modified="2010-10-05" version="1">MTDPKTLTSVAEFHKTFQHPILDQPTIPAEKRCELRVSLIAEELKELEEAIQNKDLVEIADALCDIQYVLSGAVLEFGLKDKFNALFEEVQRSNMSKACKSVKEAEETMKYYKEEKGVDSYYKEVDGLFLVFREGDNKTLKSIYYSPADLKSIIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL00</accession>
    <name>D7VL00_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11669</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999673.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11669"/>
    <dbReference type="EnsemblBacteria" id="EFK58273">
        <property type="protein sequence ID" value="EFK58273"/>
        <property type="gene ID" value="HMPREF0766_11669"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055068_4_0_10"/>
    <dbReference type="OrthoDB" id="2053476at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="69"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="291" mass="33593" checksum="58A7DD3B9719DD51" modified="2010-10-05" version="1">MAQKEFKSFWRETFKSGSPVPIVIVGQVALFVIIHLFDLLAELKVIHYPLYDKTLQYLSLPVSFEHFLKQPWSVFSYSLVYTGLFRILFDSLWLYWMGNLFLNFLNRRQLWYIYLSSLCLGGVFYLALGQIPYLANSPQTLLNTASLPIAGVITATASLVPYTEMRLLFLGNIKLKTVAYVYLGLEVIFYALINKTAAAAYLCIILWSFMFIRSLQNGKDWSKVFAAKRKRISRLQVVHQKVEYAKYSHSTINDLPNQEEIDQILDKISLSGYESLTSREKEVLFKASKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL06</accession>
    <name>D7VL06_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999693.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11675"/>
    <dbReference type="EnsemblBacteria" id="EFK58279">
        <property type="protein sequence ID" value="EFK58279"/>
        <property type="gene ID" value="HMPREF0766_11675"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047714_0_1_10"/>
    <dbReference type="OrthoDB" id="1979131at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="7"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="334" mass="38675" checksum="5292C21B8879BEC7" modified="2010-10-05" version="1">MATRAIYISNIRILATIGVIFIHATTGYLQSAAVGSFNWDYANWINGLTRCAVPLFVMISGALLLQKDESTTDFYKNRLLKIVPPFLFWTIVYIVYYFSRYTSFDQLSFQQIVTISWQKMRTGANAHLWYLYMILGLYLTVPFLRKMIRSASLREIEIFLVIWFASLYISNKRWEEYFLKIDLTFFSGYIGYFVLGYYLSVKDFSRQKIFSLLIFTVACVFTIYITHHLSIAQQKYDPSFYGYVLPNTALAAAGIFTFLKAVSSTRNIPGWMDAVDKYSFGIYLAHILILNYVHPRLPDEIWIKVPLATIATLLGSMLLIYLIRKIPYGKYVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL49</accession>
    <name>D7VL49_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11718"/>
    <dbReference type="EnsemblBacteria" id="EFK58322">
        <property type="protein sequence ID" value="EFK58322"/>
        <property type="gene ID" value="HMPREF0766_11718"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3258024_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="42" mass="4980" checksum="DD5A1E869AC2EFAD" modified="2010-10-05" version="1">MILNDILRDKLSYHCFNALSLLLWFIYFVTFALSKNIIEGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL67</accession>
    <name>D7VL67_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDDEXK_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999815.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11736"/>
    <dbReference type="EnsemblBacteria" id="EFK58340">
        <property type="protein sequence ID" value="EFK58340"/>
        <property type="gene ID" value="HMPREF0766_11736"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013279_0_0_10"/>
    <dbReference type="OrthoDB" id="1283891at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="1">
        <location>
            <begin position="676"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="979" mass="113302" checksum="ADF82D7167D122E5" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLB9</accession>
    <name>D7VLB9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxine 5'-phosphate synthase</fullName>
            <shortName evidence="2">PNP synthase</shortName>
            <ecNumber evidence="2">2.6.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">pdxJ</name>
        <name evidence="3" type="ORF">HMPREF0766_11788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15265"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="EC" id="2.6.99.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer; tetramer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.99.2" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999978.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11788"/>
    <dbReference type="EnsemblBacteria" id="EFK58392">
        <property type="protein sequence ID" value="EFK58392"/>
        <property type="gene ID" value="HMPREF0766_11788"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0854">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074563_1_0_10"/>
    <dbReference type="OrthoDB" id="1159993at2"/>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033856">
        <property type="term" value="F:pyridoxine 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00003">
        <property type="entry name" value="PNPsynthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00279">
        <property type="entry name" value="PdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004569">
        <property type="entry name" value="PyrdxlP_synth_PdxJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036130">
        <property type="entry name" value="Pyridoxine-5'_phos_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30456">
        <property type="entry name" value="PTHR30456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03740">
        <property type="entry name" value="PdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63892">
        <property type="entry name" value="SSF63892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00559">
        <property type="entry name" value="pdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="3-amino-2-oxopropyl phosphate binding" evidence="2">
        <location>
            <begin position="214"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="238" mass="26511" checksum="76A965EA7C2B558B" modified="2010-10-05" version="1">MTRLSVNINKIATLRNSRGGNNPSVLAAALACERFGAQGITVHPRPDERHIRYTDVYDLKENITTEFNIEGNCREQKFVDLVLANKPAQVTLVPDEEGQITSNHGWDTIKHQAYLKEMCTLFKDHGIRVSIFVDPDPEMVEAAAETGTDRIELYTEAYATAFLDEREAAIQPYFKAAQKANEVGLGINAGHDLDLNNLTYFNQHIPGLLEVSIGHALIADALYLGLEETIKRYLAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLC7</accession>
    <name>D7VLC7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ser/Thr phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000002.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11796"/>
    <dbReference type="EnsemblBacteria" id="EFK58400">
        <property type="protein sequence ID" value="EFK58400"/>
        <property type="gene ID" value="HMPREF0766_11796"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2908">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061126_2_0_10"/>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043461">
        <property type="entry name" value="LpxH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34990">
        <property type="entry name" value="PTHR34990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="2">
        <location>
            <begin position="7"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="275" mass="31971" checksum="AEBF5195A854A8A4" modified="2010-10-05" version="1">MKREVDLVILSDVHLGTYGCRAQELLQYLRSIKPRKLILNGDIVDIWQFKKSYFPDSHLLVIKYIFELACQDTEVIYITGNHDEMLRKFANVHFGNILLTNKIILNLGGKLAWIFHGDVFDASVHHAKWLAKLGGWGYDKLIQLNNLVNWVLSKMGREKYSFSKKIKNSVKKAVKYINDFEETASELAIEQNYDYVICGHIHQPQIRTVKTKKGETIYLNSGDWVENLTALEYHEGEWEMFVYENSKHLLGKYPTPEVSFKTSVDQLLENILKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLD2</accession>
    <name>D7VLD2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipid A biosynthesis (KDO)2-(Lauroyl)-lipid IVA acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_11801</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000013.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11801"/>
    <dbReference type="EnsemblBacteria" id="EFK58405">
        <property type="protein sequence ID" value="EFK58405"/>
        <property type="gene ID" value="HMPREF0766_11801"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049421_4_1_10"/>
    <dbReference type="OrthoDB" id="1106624at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="274" mass="32146" checksum="471ECF76F6F043EF" modified="2010-10-05" version="1">MLYMKAQKQNNKKNLSLQHMNSMYRIMGFMIGRIFRYRYNVVIQNFARAFPDMSYTTIVHHAHDFYCILGRIVIEQLSGIFRSPKLHVQNTQLLDTPYREKRHIIILMGHYGNWELLNRLPALLSRPVQALYKPLKNNLFDRLAQKSRTREGLRLLPSSQALRTLLKEKNSPHITVFLADQYPGPENGYAVTFLNQQTYAFSGAEKIAKTLNAYVVYGEFFPTGDYNWTLRLDLICESASQTSVGEITQNYTRKLEDSIIKAPSYWLWSHRRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLD3</accession>
    <name>D7VLD3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane insertion signal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000016.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11802"/>
    <dbReference type="EnsemblBacteria" id="EFK58406">
        <property type="protein sequence ID" value="EFK58406"/>
        <property type="gene ID" value="HMPREF0766_11802"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082049_5_1_10"/>
    <dbReference type="OrthoDB" id="1035939at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025665">
        <property type="entry name" value="OMP_b-brl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13568">
        <property type="entry name" value="OMP_b-brl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107280" evidence="1">
        <location>
            <begin position="25"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl_2" evidence="2">
        <location>
            <begin position="24"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="188" mass="21138" checksum="7595D8E92FBB76D6" modified="2010-10-05" version="1">MNKNLKTGFALLALTLGLTLTAHAQKVEYGIKAGAQYSSFSYGNKSIKDEAGKIGVHIGVFARTTEKLYFQPELNFSMFKAKYTYESKVYTPKFYQANLPLQVGYKVLEKDDLNLRVSAGPQLNYDLKKVKATATTSFKQLSYDALINVGADVEKFTFDLRFNYGLNKRNKDLGARNETYGLSVGYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLE3</accession>
    <name>D7VLE3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11813</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000045.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11813"/>
    <dbReference type="EnsemblBacteria" id="EFK58416">
        <property type="protein sequence ID" value="EFK58416"/>
        <property type="gene ID" value="HMPREF0766_11813"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_0_1_10"/>
    <dbReference type="OrthoDB" id="448804at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="123"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="303"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="613" mass="69388" checksum="37E0935D9F77CA64" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLF1</accession>
    <name>D7VLF1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000067.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11821"/>
    <dbReference type="EnsemblBacteria" id="EFK58424">
        <property type="protein sequence ID" value="EFK58424"/>
        <property type="gene ID" value="HMPREF0766_11821"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025928_3_0_10"/>
    <dbReference type="OrthoDB" id="319098at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041662">
        <property type="entry name" value="SusD-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12771">
        <property type="entry name" value="SusD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="528" mass="58525" checksum="5D8600AEDE72CFBA" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLG6</accession>
    <name>D7VLG6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000109.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11836"/>
    <dbReference type="EnsemblBacteria" id="EFK58439">
        <property type="protein sequence ID" value="EFK58439"/>
        <property type="gene ID" value="HMPREF0766_11836"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1189302_0_0_10"/>
    <dbReference type="OrthoDB" id="2058305at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="230" mass="26737" checksum="563969F515FB83B9" modified="2010-10-05" version="1">MKRVLSTLLLLSGILILGCKKDPGYEELNRLADEKYQEIVQLTQSVACGDPSVWKIATIYQLGPVYLPVHPSFEERYNKLVEEYHVRRKRADNAPDAPPIPYLDYIESYPPIGIRCKNNKAELYYAKDMTLQEIEEELPKYFTEIVDFHKNDPCTNPNLWRIGYIRQDCKYIAVLYNENIRGEEFYKKGRQYESLYAQKRKLQASPPCSNQNDKPAKGVSCENGKPVIQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLM0</accession>
    <name>D7VLM0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000223.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11890"/>
    <dbReference type="EnsemblBacteria" id="EFK58493">
        <property type="protein sequence ID" value="EFK58493"/>
        <property type="gene ID" value="HMPREF0766_11890"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117507_0_0_10"/>
    <dbReference type="OrthoDB" id="1537812at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="218" mass="24504" checksum="9EA2C6B6EEACF5B3" modified="2010-10-05" version="1">MGKAKVKRTSTSIDMTAMCDVSFLLLTFFVLTSTARQPEAFPVDTPASTTKDKLPDTNLGIITIGGEGKVFFGVKEREVRKRMLERMSAKYNIQFSQEDYQKFELAEDFGVPIKNLRQLLTLDVSQRVQPGVQTGIPVDSTENTTNELYHWVQSARLATAEITKEKESEKDFVDPGPMKIAIKADANEKYPSINLVIETLRNQKQNKFSFVTGLKGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLM3</accession>
    <name>D7VLM3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative translation initiation factor SUI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_11893</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000232.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11893"/>
    <dbReference type="EnsemblBacteria" id="EFK58496">
        <property type="protein sequence ID" value="EFK58496"/>
        <property type="gene ID" value="HMPREF0766_11893"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0023">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082805_4_1_10"/>
    <dbReference type="OrthoDB" id="1752091at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11567">
        <property type="entry name" value="YciH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005872">
        <property type="entry name" value="SUI1_arc_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037511">
        <property type="entry name" value="Transl_init_SUI1_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="SSF55159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="4">
        <location>
            <begin position="42"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="116" mass="12970" checksum="15A0B53B885AC1C0" modified="2010-10-05" version="1">MNKHKKQRFEGIVYSTSDDFDYQESDITEEAETLPANKQLLKVMLDRKMRKGKVVTIVTGFIGSDTDLEILAKKLKQKCGVGGTSKNGEIMIQGDFKQKIVDLLNQDGYKVKVVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLN7</accession>
    <name>D7VLN7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000270.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11907"/>
    <dbReference type="EnsemblBacteria" id="EFK58510">
        <property type="protein sequence ID" value="EFK58510"/>
        <property type="gene ID" value="HMPREF0766_11907"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012729_0_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041700">
        <property type="entry name" value="OMP_b-brl_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14905">
        <property type="entry name" value="OMP_b-brl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107290" description="OMP_b-brl_3 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl_3" evidence="2">
        <location>
            <begin position="444"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="931" mass="103707" checksum="7E5E3992B86C1B28" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM18</accession>
    <name>D7VM18_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001210.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK58023">
        <property type="protein sequence ID" value="EFK58023"/>
        <property type="gene ID" value="HMPREF0766_12015"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2354">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059391_0_0_10"/>
    <dbReference type="OrthoDB" id="1419056at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008526">
        <property type="entry name" value="YedI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30503">
        <property type="entry name" value="PTHR30503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05661">
        <property type="entry name" value="DUF808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016660">
        <property type="entry name" value="YedI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="290" mass="30992" checksum="E476002C24E5C60C" modified="2010-10-05" version="1">MASGFFAILDDIAALMDDVAVTSKIATQKTAGILGDDLAVNAEKATGFLSSRELPVLWAITKGSLINKLIIVPIALLLNVFFPIAIKFILVLGGFYLAYEGVEKIIEYFFHRSKKGHEVIAERKENDSEVEKTKIKSAVTTDFILSVEIVIIALGTVLDKSLTLQIITVSVVALVATIGVYGIVALIVRMDDAGYKLIKHSNDKGLLSKLGHLLVSSLPIIIKCLAVVGTVALILVSGGIFVHNIDYLHHIAPNIPSIIKEVTIGLIAGLLVVALVTGSKKLIGLFKTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM43</accession>
    <name>D7VM43_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001277.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12040"/>
    <dbReference type="EnsemblBacteria" id="EFK58048">
        <property type="protein sequence ID" value="EFK58048"/>
        <property type="gene ID" value="HMPREF0766_12040"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119554_0_0_10"/>
    <dbReference type="OrthoDB" id="1526822at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="159" mass="18418" checksum="5CB426313F417C82" modified="2010-10-05" version="1">MTEKTAFTIREFEADDHAQIIGLLRLNTPEYFSSEEEADLIHYLQHEIDHYYVVESDGVIIGCGGINFAEDKTVGKISWDILHPDFQGQAIGSALLKYRINELQHTHHIQKITVRTSQLVYKFYEKNGFILTKIAKDYWAPGYDLYSMRYDPGTDQKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM53</accession>
    <name>D7VM53_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha</fullName>
            <shortName evidence="10">ACCase subunit alpha</shortName>
            <shortName evidence="10">Acetyl-CoA carboxylase carboxyltransferase subunit alpha</shortName>
            <ecNumber evidence="10">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">accA</name>
        <name evidence="13" type="ORF">HMPREF0766_12050</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the AccA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="10"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001311.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12050"/>
    <dbReference type="EnsemblBacteria" id="EFK58058">
        <property type="protein sequence ID" value="EFK58058"/>
        <property type="gene ID" value="HMPREF0766_12050"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015486_0_2_10"/>
    <dbReference type="OrthoDB" id="886663at2"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00823">
        <property type="entry name" value="AcetylCoA_CT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001095">
        <property type="entry name" value="Acetyl_CoA_COase_a_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42853">
        <property type="entry name" value="PTHR42853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03255">
        <property type="entry name" value="ACCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01069">
        <property type="entry name" value="ACCCTRFRASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00513">
        <property type="entry name" value="accA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="13" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="12">
        <location>
            <begin position="38"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="11"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFK58058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="317" mass="35208" checksum="7C2150C2C7758381" modified="2010-10-05" version="1">METTFDFEKPIADLQTQIEKVNQVAEKTKVDMSATIQDLEAKLEETKLQIYNNMTGWQKVQMSRHPERPQTFDYIEMICEEFIELHGDRNVKDDKAIVGGFASIGGEAVMVIGHQKGKNTKERQFRNFGMANPEGYRKALRLMKMAEKFNKPVITLIDTMGAYPGLEAEERGQGEAIARNLLEMSVLKVPVICIVIGEGASGGALGIGIGDRVYMLQNTWYSVISPESCSSILWRSWDHKERAAEALKLTAEDMLGNGLIDGIIAEPLGGAHQEPAIAAENVKTKILSDLAVLKAKTAEVLVQERIDKFSKMGYVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM92</accession>
    <name>D7VM92_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001379.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12089"/>
    <dbReference type="EnsemblBacteria" id="EFK58097">
        <property type="protein sequence ID" value="EFK58097"/>
        <property type="gene ID" value="HMPREF0766_12089"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4283">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124046_0_0_10"/>
    <dbReference type="OrthoDB" id="1368382at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012550">
        <property type="entry name" value="DUF1706"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40658">
        <property type="entry name" value="PTHR40658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08020">
        <property type="entry name" value="DUF1706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031551">
        <property type="entry name" value="DUF1706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="172" mass="20118" checksum="BED13095237F47B6" modified="2010-10-05" version="1">MAIPTNKEQLLIAIKSNYDKLMKELADIPLADTSIPELEGHAKDTYMSVHNLVSYLIGWGELVLKWNRKKDLQETVDFPETEYKWNQLGILAQKFYSDYETIPYPELLKRLDTTVGDILQLIGRKTNRELYEESWYEKWTLGRMIQFNTASPYTNARARIRNWKKLKGAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMD1</accession>
    <name>D7VMD1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001457.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK58136">
        <property type="protein sequence ID" value="EFK58136"/>
        <property type="gene ID" value="HMPREF0766_12128"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503361D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1093745_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="254" mass="29799" checksum="849D8491AD9BD4CF" modified="2010-10-05" version="1">MKREILFKGVTKLKVKGKDRYSALLLMVLLTLFLSCKQEDKFDLLNLSFPVKKELLNSMGIETKDYNTYLEGEIRKFSSEKDSVLIFGNVKLSGNISRYNKDLFFANYVDFFEDPLQKNIGAYQVNIHTTEETKALEEFMAEHFGKTDFYYKDKKISCRIWEADNRILFFGVMNDQHHPDLPNKVQSTCMLFVIDKSNKELMKESPQGSYFKFYKDYLDKKESTKQQAEVYIYSDFVHDSGNETIYTTNYVGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMI0</accession>
    <name>D7VMI0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_12177</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001562.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12177"/>
    <dbReference type="EnsemblBacteria" id="EFK58185">
        <property type="protein sequence ID" value="EFK58185"/>
        <property type="gene ID" value="HMPREF0766_12177"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054750_0_0_10"/>
    <dbReference type="OrthoDB" id="1274094at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="252" mass="28038" checksum="C51B1DD168741AB4" modified="2010-10-05" version="1">MQEAFDLLHSPYHWVLYFFCAMLIGMSKTGVQNIGTLAVPLFAFLFGARYSTGIVLILLCMADLIAVIYYRKQFRWSEIKGMLPAAFVGLLGGLFLANNMDDQLFRVLMGICILSGVGIMIWMEKSKSVSTVAEKSWYAPLFGFIAGFSTMIGNAAGPALSVYLLSRKLPKYAFVATGAWFIMILNYTKIPLQLFVWHNLSWAGIILNVFAIPFILLGGYLGIRIIKVIPEKQFRILAMALVAVSALLLIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMI6</accession>
    <name>D7VMI6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12183"/>
    <dbReference type="EnsemblBacteria" id="EFK58191">
        <property type="protein sequence ID" value="EFK58191"/>
        <property type="gene ID" value="HMPREF0766_12183"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2071635_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="118" mass="13898" checksum="4A05F02A8EAFE35A" modified="2010-10-05" version="1">MKYIIFLLLFGISVHSYAQIKIFVTKEKKQLDYDGYLLGLKVIKDGKSYETKPGDYYSWFYFLNNFDLKDRVRILKKLSKYFDDYSLCSKAVEPVFPGVGIPRTADRFSQQKRNTVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMK4</accession>
    <name>D7VMK4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992641.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12224"/>
    <dbReference type="EnsemblBacteria" id="EFK57151">
        <property type="protein sequence ID" value="EFK57151"/>
        <property type="gene ID" value="HMPREF0766_12224"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032SI8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138456_0_0_10"/>
    <dbReference type="OrthoDB" id="1779307at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021398">
        <property type="entry name" value="DUF3037"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11236">
        <property type="entry name" value="DUF3037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="125" mass="14457" checksum="8A1CD75290F0C100" modified="2010-10-05" version="1">MKNVFEYAVVRLVPRVEREEFINVGVILYSKRTRYSGFLWQLNDDKCSVLCRDLDVAMIRQHLHSFEQICNGSSDGGKLAELDQAERFRWLTARRSTLIQCSPVHPGLTENPADTLQDLFEKLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VML4</accession>
    <name>D7VML4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EVE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992668.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12234"/>
    <dbReference type="EnsemblBacteria" id="EFK57161">
        <property type="protein sequence ID" value="EFK57161"/>
        <property type="gene ID" value="HMPREF0766_12234"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2947">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041799_2_1_10"/>
    <dbReference type="OrthoDB" id="1829674at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="1">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="137" mass="15942" checksum="66BC2986F2424014" modified="2010-10-05" version="1">MNYFLVKSEPFKYSWEQFNKDGQTFWDGVRNYQARNNIKAMKEGDLVLFYHSNEGKEVVGIAKVVKEFYHDPTTEDERWVVVDLAPVETFKNPVTLEQIKSDTLLQDVALVRQGRLSVMPLKPEEFDRIVELGNQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMP3</accession>
    <name>D7VMP3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fibronectin type III domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992719.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12263"/>
    <dbReference type="EnsemblBacteria" id="EFK57190">
        <property type="protein sequence ID" value="EFK57190"/>
        <property type="gene ID" value="HMPREF0766_12263"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7QF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036289_1_0_10"/>
    <dbReference type="OrthoDB" id="1249411at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032530">
        <property type="entry name" value="DUF4957"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033427">
        <property type="entry name" value="DUF5123"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16318">
        <property type="entry name" value="DUF4957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17161">
        <property type="entry name" value="DUF5123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="41"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="521" mass="54571" checksum="1FE06BBCFF36475F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMR4</accession>
    <name>D7VMR4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">tatC</name>
        <name evidence="6" type="ORF">HMPREF0766_12284</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms a complex with TatA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992755.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12284"/>
    <dbReference type="EnsemblBacteria" id="EFK57211">
        <property type="protein sequence ID" value="EFK57211"/>
        <property type="gene ID" value="HMPREF0766_12284"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031942_3_2_10"/>
    <dbReference type="OrthoDB" id="1848013at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK57211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="292" mass="32926" checksum="23C133CAFE207EB9" modified="2010-10-05" version="1">MSKMTKSSLVQAIKDKGKNIEGEMSFFDHLEVLRWHIIRSVLAVAVFATLAFTFYDYVFNEIIMGPKKLDFWTYRMMCKVGELLHIDGFCVERIPFNIINTEMAGQFMLQINSCLITAVALGFPYLLFEVWLFVKPALTDIEKRSARGFVFYATILFALGVLFGYYIVVPLSVNFLSNVSLSEEITNQITIDSYLSTIATLSLGCGIVFLLPILIFILSKIGLMTPEFMRASRRYAVVIILVIAAVITPSADVITMLTVSAPMFILYEISIMVSANVKKARAAKEKEFYSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMU9</accession>
    <name>D7VMU9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yeeF</name>
        <name evidence="7" type="ORF">HMPREF0766_12319</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992814.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12319"/>
    <dbReference type="EnsemblBacteria" id="EFK57246">
        <property type="protein sequence ID" value="EFK57246"/>
        <property type="gene ID" value="HMPREF0766_12319"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_15_12_10"/>
    <dbReference type="OrthoDB" id="527053at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease_C" evidence="6">
        <location>
            <begin position="512"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="566" mass="62286" checksum="F225851A37EB8AF1" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMV4</accession>
    <name>D7VMV4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992825.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12324"/>
    <dbReference type="EnsemblBacteria" id="EFK57251">
        <property type="protein sequence ID" value="EFK57251"/>
        <property type="gene ID" value="HMPREF0766_12324"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0767">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045686_1_1_10"/>
    <dbReference type="OrthoDB" id="1253502at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="244" mass="25588" checksum="812476F087E262B3" modified="2010-10-05" version="1">MLIYHIGKYILLLKSVFKKPEKGKIYWKETMFAMTDIGLGSLGLIVIISTFIGAVMTMQIAFQLVSDLIPNSIIGQINRDSNILELGPTISALVLMGKVGSSISSQIGSMRVTEQIDALEIMGINAPGYLILPKILAGITMIPALVIVAIFCAILGGLLGGALSGAVSTADYIQGIQGSFNGFTVSVAMVKAVVFGFIITSVPAYKGFYVSGGALEVGEAGTQAVVIGCITILASDYLITALML</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN09</accession>
    <name>D7VN09_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4476 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992903.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12379"/>
    <dbReference type="EnsemblBacteria" id="EFK57306">
        <property type="protein sequence ID" value="EFK57306"/>
        <property type="gene ID" value="HMPREF0766_12379"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1115209_0_0_10"/>
    <dbReference type="OrthoDB" id="1181112at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028011">
        <property type="entry name" value="DUF4476"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14771">
        <property type="entry name" value="DUF4476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107139" description="DUF4476 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4476" evidence="2">
        <location>
            <begin position="156"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="249" mass="29128" checksum="152D786B70F2FEF3" modified="2010-10-05" version="1">MIIRKLFFSLIAFLCLTSAFAQTPNSTNGVFSVFSEREPFILYLNNVRYNDQYSTAVRIERLEKRSYDVRLEFKNRRLASIVSYNFRPTDEDGYFMDKMYLVRYSRVGRPELRLFAMFPVEFRMPDQRSFDTYDFGYPNDPVFVDPGEGEYSQRVMTAEELKDAIRVVNRQGFDSDKAKVASMIAQKNSMTVKQIGQVLDLFSFDDGKLTFARAAYATCYDRRNYHTLLDKLVFSDSKEKLMSFINSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN18</accession>
    <name>D7VN18_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease, YjgP/YjgQ family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_12388</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992914.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12388"/>
    <dbReference type="EnsemblBacteria" id="EFK57315">
        <property type="protein sequence ID" value="EFK57315"/>
        <property type="gene ID" value="HMPREF0766_12388"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028799_6_0_10"/>
    <dbReference type="OrthoDB" id="1558251at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="494" mass="56551" checksum="D55D513F73A241BF" modified="2010-10-05" version="1">MKKIHLLILQSFIKPFIVTFCIVMFVLLMLFLFKYIDDLIGKGFEWYVILQLIGYQCAVQMQMALPLSMLLSSIMTFGNLGESYELVAIKAAGVSLRKAMTPLFILVALFSAGSFLFSDYILPVVNLKMGSLLYDVRNKKADFLIKPGIFNNTIPGYAIRAKSKSKDGTVLNELMIYDHTSGSSSNNVLLAKEGFVQNSPDNSYMVLKLKDGIRYEESKGKDSKSYDPRKQFVRFQFKETEQKFDMGDFQMKRTDENLFKSHHAMLNLRQLKMYTDSNHRQMDSVGRMAEHDIRNYYNYYSNYFRSPGMKIVPAKVKPFKNLLEDVVPATERRQIVGSAMTQSRYITETLGNKTLEYKAFRDKDIRYRLEFHRKFTLAVSCLLLFGIGAPLGAIIRKGGLGLPVVMAIIFFLIYHIISTVSEKAAKDASLAPMTGMWMAIIVLTPLAIFLTYKSTTDSSLFDVEQYKLKAQSIWKWIRTRFTKHKNIPQQGTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN37</accession>
    <name>D7VN37_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VRR-NUC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_12407</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992937.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12407"/>
    <dbReference type="EnsemblBacteria" id="EFK57334">
        <property type="protein sequence ID" value="EFK57334"/>
        <property type="gene ID" value="HMPREF0766_12407"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033CID">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129193_0_1_10"/>
    <dbReference type="OrthoDB" id="2021091at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VRR-NUC" evidence="4">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="118" mass="13466" checksum="817B6E30DF90CBDF" modified="2010-10-05" version="1">MSEIQLQSKCFQWLWNNYPQTRRKFFHVPNGGSRNAVEGMQLKASGVVAGIPDCVLIHMGNAYGFEMKTQSGKVSPEQQKVHKVWQDDGTPVYIIRSFEEFQFEIFTIIGEPKKEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN99</accession>
    <name>D7VN99_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, alpha/beta domain protein</fullName>
            <ecNumber evidence="2">3.1.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993020.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12469"/>
    <dbReference type="EnsemblBacteria" id="EFK57396">
        <property type="protein sequence ID" value="EFK57396"/>
        <property type="gene ID" value="HMPREF0766_12469"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_4_10"/>
    <dbReference type="OrthoDB" id="1361074at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="83"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="310" mass="34564" checksum="5A3052D6BE2AD35B" modified="2010-10-05" version="1">MKTVQFNPEINKIMENIQMIHVFDGKTPLDIGRKGYETMAVQLSGKKEPVTIIEEFNIPGNNHEIPVRIYRPKGVEREKSAAIIYLHGGWFVSGSFETHDAVVRQLANATGEAIVFVDYRLAPEHPFPAGLNDALSATQWIISNADHLHINKNKIGIIGDSAGGALAVSAATQLGRKLKFQVLIYPAADNKLNTVSWQKYETGPIINKEEGIRAWNWYLSTPEDQHNQLAVPLLIKDFKDTPPALVLLAEHDPLRDEGRQLAENMKTSGVHVKTVVYKDMVHGFMHMGAVLKETKEAILEIAAFTKENLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNC7</accession>
    <name>D7VNC7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacterial stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">terZ</name>
        <name evidence="2" type="ORF">HMPREF0766_12497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993055.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12497"/>
    <dbReference type="EnsemblBacteria" id="EFK57424">
        <property type="protein sequence ID" value="EFK57424"/>
        <property type="gene ID" value="HMPREF0766_12497"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055120_3_1_10"/>
    <dbReference type="OrthoDB" id="1437267at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="203" mass="22421" checksum="050BD204EE86349A" modified="2010-10-05" version="1">MAINLQKGQKINLQKNNGSTLQNICVGVNWGAIEKKGWLGNVTREAVDLDASCVLYDTSRNLIDVVYFGSLRSKDGAILHSGDDLTGDMDGDDGLDNEIITLDFTRLNPAVNHVAFVLNSFRGHDFGTIPFASIRIYEGTPTRVNEVFATYDIVKGTGFAGHVSMVLGIFYKRNGEWKFNAVGEPTKDRKLEETIKTVAQNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VND3</accession>
    <name>D7VND3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein, TerC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">alx</name>
        <name evidence="7" type="ORF">HMPREF0766_12503</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TerC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993066.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12503"/>
    <dbReference type="EnsemblBacteria" id="EFK57430">
        <property type="protein sequence ID" value="EFK57430"/>
        <property type="gene ID" value="HMPREF0766_12503"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045644_1_2_10"/>
    <dbReference type="OrthoDB" id="1917125at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="PTHR30238:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03718">
        <property type="entry name" value="R_switched_Alx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="339" mass="37951" checksum="E9AAAA23810ED212" modified="2010-10-05" version="1">METSILDLHPGLVWGFALTVIIMLLLDLGVFNKKSHIVTSKEATIWTFVWISLAMIFSGIVYYVFNGDAGGHQLAIEKFTQFQAAYWIEKALSVDNLFVFILVFSYFKVPRNLHHKVLFWGILGALVFRAIFIFAGVGIINITYLPAMQLLGHTVEINVVLTLFGLFLIYAGIKSWGGGDEDDEQDFSNSAGARLIKKLYKVSDNYDRDRFFTVQNGMKIATPLLVVVAVIEFTDVLFAVDSIPAIFAISKDPFILYTSNIFAILGLRSLYFLLSNFIHMFSKLPYGLSVILAFIGIKMLISPWFHIPSPVSLGIVGGVLIISVLLSILFPEKKELETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNG2</accession>
    <name>D7VNG2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonine synthase</fullName>
            <ecNumber evidence="5">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">thrC</name>
        <name evidence="12" type="ORF">HMPREF0766_12532</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993103.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12532"/>
    <dbReference type="EnsemblBacteria" id="EFK57459">
        <property type="protein sequence ID" value="EFK57459"/>
        <property type="gene ID" value="HMPREF0766_12532"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015170_0_0_10"/>
    <dbReference type="OrthoDB" id="428821at2"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Thr_synth_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="PALP" evidence="10">
        <location>
            <begin position="97"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK57459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="435" mass="48187" checksum="039DC929A2A4F59B" modified="2010-10-05" version="1">MKLYSTQNKDLRVSFKDAVFNSLPADKGLYMPEVIPQLDPMFIRNIQQYSLEEIAFTVAHALIGQDIPADDLKKIIKDAINFDAPVRFLSKDTAVLELFHGPSYAFKDFGARFMSRVMGYFSQSDDKLLDVLVATSGDTGGAVALGFLGVEGTRVTILYPKGKVSEVQEQQLTTNGQNIRALEVDGTFDDCQALVKKAFNDAELNRELRLTSANSINIARLIPQTFYYFYAYAQLKAQGINQVVFSVPSGNFGNIGAGLLAFKMGLPVEKFVAATNVNDTVPRFLSSGQYQPKPSVQTLANAMDVGDPSNWVRILDLFDQDLEALKKVVTSYTYDDEATKAAMKQLYLEYQYVACPHTAIAWLASQAYLGEHPGQYASVFLSTAHPCKFPDAIDADVFEKVKLPEGAETLSGKEKLAKELPVDYDLFKAYLLENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNI1</accession>
    <name>D7VNI1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 13">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">yidC</name>
        <name evidence="16" type="ORF">HMPREF0766_12551</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993130.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12551"/>
    <dbReference type="EnsemblBacteria" id="EFK57478">
        <property type="protein sequence ID" value="EFK57478"/>
        <property type="gene ID" value="HMPREF0766_12551"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016535_2_0_10"/>
    <dbReference type="OrthoDB" id="524437at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01810">
        <property type="entry name" value="YidC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019998">
        <property type="entry name" value="Membr_insert_YidC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028053">
        <property type="entry name" value="Membr_insert_YidC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038210">
        <property type="entry name" value="YidC_periplasmic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038221">
        <property type="entry name" value="YidC_periplasmic_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14849">
        <property type="entry name" value="YidC_periplas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00701">
        <property type="entry name" value="60KDINNERMP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03593">
        <property type="entry name" value="yidC_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="481"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="522"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="YidC_periplas" evidence="15">
        <location>
            <begin position="87"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="575"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="575"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFK57478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="607" mass="68922" checksum="008D8DFCA14DA30E" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNK1</accession>
    <name>D7VNK1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PRTRC system ThiF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993153.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12571"/>
    <dbReference type="EnsemblBacteria" id="EFK57498">
        <property type="protein sequence ID" value="EFK57498"/>
        <property type="gene ID" value="HMPREF0766_12571"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070016_0_0_10"/>
    <dbReference type="OrthoDB" id="1414532at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022500">
        <property type="entry name" value="PRTRC_ThiF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03736">
        <property type="entry name" value="PRTRC_ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="22"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="268" mass="29986" checksum="3C1CFD16B7C12C38" modified="2010-10-05" version="1">MSKEILKVHFTDSDLINPTNPITVNVIGAGGTGSKVMTALLEMNHSLNELGHAGLFIRLWDDDVITQANLGRQRFAESEVGLYKSVAIINRINRFSGTNWKAEARKFEKDNSDSFPENAGASIYISCVDSVKARFEIAEILSELSNGRPYSNRPRYWLDFGNSQHTGQVLLSTIGKIRQPNSEKYETVASLPMVTDEFGELLKQSELEDDTPSCSLAEALEKQDLYINSSLVQMGCSLLWGMFKNGLTPYRGFFHNLKDFRTHPIKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNR1</accession>
    <name>D7VNR1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993237.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12631"/>
    <dbReference type="EnsemblBacteria" id="EFK57558">
        <property type="protein sequence ID" value="EFK57558"/>
        <property type="gene ID" value="HMPREF0766_12631"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093779_0_0_10"/>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="204" mass="22896" checksum="BD37E2910F0DDD06" modified="2010-10-05" version="1">MYKNLAETIKGISDVQTVSEERKTILQPLIDFVQQKVSNGQVINLNFICTHNSRRSHLSQVWAQVASVYYHIPNVYCYSGGTEETALFPKVVETLNEQGFSAFKISEADNPVYAIKYSENALPIIGFSKKYDSPFNPVSAFTAIMTCSQADDGCPFIAGAEKRIPITFEDPKISDGTTEQTKIYAERSLEIATEMFYVFSMIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNU7</accession>
    <name>D7VNU7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993298.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12667"/>
    <dbReference type="EnsemblBacteria" id="EFK57594">
        <property type="protein sequence ID" value="EFK57594"/>
        <property type="gene ID" value="HMPREF0766_12667"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131572_0_0_10"/>
    <dbReference type="OrthoDB" id="1866491at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="154" mass="17610" checksum="5798C904E5B19FC2" modified="2010-10-05" version="1">MKNYVYKEAKAFSTNEINIFKNILINANEVSEVTFDGLIEKNPKLLIVGNIKEPLGIAALKNPNKTYKEKVFRLSGTEKDSKEYRFELGWVVSLEKGNGNKIVELISNSENNIYSTVREKNQKMISLLKKYGFSQAGNSYKSERGDYQILLFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNZ8</accession>
    <name>D7VNZ8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HlyD_D23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993385.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12718"/>
    <dbReference type="EnsemblBacteria" id="EFK57645">
        <property type="protein sequence ID" value="EFK57645"/>
        <property type="gene ID" value="HMPREF0766_12718"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_13_1_10"/>
    <dbReference type="OrthoDB" id="949250at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="2">
        <location>
            <begin position="106"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="436" mass="47875" checksum="A6898950C88C952F" modified="2010-10-05" version="1">MKRNYIVKLVQDRTTGRLLQTCSRKDRKGTKLRKLQIAFTFPALIILLLTTVFVSCKQESKKEHHDVGKITIDSSLSTLLQPSNKQVVGNMAVVKASYQSKIMLAEVQGIVNYDNRAETGVASRVGGRLEKINVKYNYQPVRKGQLLFEIYAPDLAAAQQELLYLAQSGEEPLLSRARQRLMLLGMTAEDIQKVLQIKKVNYRIPVYSPADGFILEKSVANAISTPAPAMTSGGGGDGMAGMNGSNETATTAAPATTIQNTSVMLREGQYVSAGQSLFTIYKSDQLLAEFALKPALAAYVNKGTKLGFYKTTDKEGTFQTSTIGLIQPMIKSGENFTLARVYLTKGRFKAGEILTAKIPIYIKGSYWLPASAILSAGAQRIVFKKENNVFKPVNIETGLRIDGMVQINQDISPWEFAKDAAYLVDSESFIKAGNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP93</accession>
    <name>D7VP93_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease R</fullName>
            <shortName evidence="6">RNase R</shortName>
            <ecNumber evidence="6">3.1.13.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rnr</name>
        <name evidence="8" type="ORF">HMPREF0766_12813</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.13.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RNR ribonuclease family. RNase R subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.1" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993561.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12813"/>
    <dbReference type="EnsemblBacteria" id="EFK57740">
        <property type="protein sequence ID" value="EFK57740"/>
        <property type="gene ID" value="HMPREF0766_12813"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002333_7_3_10"/>
    <dbReference type="OrthoDB" id="1602988at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008859">
        <property type="term" value="F:exoribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01895">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040476">
        <property type="entry name" value="CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013223">
        <property type="entry name" value="RNase_B_OB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004476">
        <property type="entry name" value="RNase_II/RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011805">
        <property type="entry name" value="RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17876">
        <property type="entry name" value="CSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08206">
        <property type="entry name" value="OB_RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00358">
        <property type="entry name" value="3_prime_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02063">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="627"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK57740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="709" mass="81116" checksum="7A592685DF2E11EF" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPB3</accession>
    <name>D7VPB3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transketolase, C-terminal domain protein</fullName>
            <ecNumber evidence="4">2.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tktA2</name>
        <name evidence="4" type="ORF">HMPREF0766_12833</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993592.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12833"/>
    <dbReference type="EnsemblBacteria" id="EFK57760">
        <property type="protein sequence ID" value="EFK57760"/>
        <property type="gene ID" value="HMPREF0766_12833"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_350462_0_0_10"/>
    <dbReference type="OrthoDB" id="900125at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="3">
        <location>
            <begin position="472"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="806" mass="90698" checksum="7ACC0A1717313C49" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPF5</accession>
    <name>D7VPF5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993660.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12875"/>
    <dbReference type="EnsemblBacteria" id="EFK57802">
        <property type="protein sequence ID" value="EFK57802"/>
        <property type="gene ID" value="HMPREF0766_12875"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_1_0_10"/>
    <dbReference type="OrthoDB" id="1031920at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="171"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="338" mass="38276" checksum="67A443E58506FD60" modified="2010-10-05" version="1">MSDSENKNIVSDLLTEPQYRGLRYLFVFVAILATTLSQSFFVFGKSAEISTGTIYFFGAALALSTFIIIYFNVSYFAPYYLSKKEYASYLLILFLLVSILVFAKGAGEFYLFATAGIQKHVNMITILDGLSNMVLYSICVASTSIGIIFRQLLEDKTKIENLESKQLRNSIEEIKNRIQPAFLYATLDYTSKIVKSKPIQASDTLYKLSDLLRYQLYDSTRHQVLLTSEIAFIRNYLLIHQQNNEGNFSFEVIMNGNCNKLIAPSVFTPCIEVLIGLNATNICADFSIQGEEVELKLLVSGIDEENDFNEAFKKLKSVYENPILIKKAANNLKIRIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPJ6</accession>
    <name>D7VPJ6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, ATP-binding protein</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_12916</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993764.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12916"/>
    <dbReference type="EnsemblBacteria" id="EFK57843">
        <property type="protein sequence ID" value="EFK57843"/>
        <property type="gene ID" value="HMPREF0766_12916"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_10"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="321"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK57843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="541" mass="61267" checksum="B39304D8FFEBAFBA" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPP9</accession>
    <name>D7VPP9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57896">
        <property type="protein sequence ID" value="EFK57896"/>
        <property type="gene ID" value="HMPREF0766_12969"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3239796_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="43" mass="5036" checksum="17CECACADB934696" modified="2010-10-05" version="1">MFHNYRLGNTAMLLIISLKKIEPKLHFYLKQKTVILLTTFAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPZ1</accession>
    <name>D7VPZ1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993957.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13045"/>
    <dbReference type="EnsemblBacteria" id="EFK55842">
        <property type="protein sequence ID" value="EFK55842"/>
        <property type="gene ID" value="HMPREF0766_13045"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_466108_0_0_10"/>
    <dbReference type="OrthoDB" id="324626at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="Pectate_lyase_SF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pectate_lyase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pectate_lyase_3" evidence="1">
        <location>
            <begin position="239"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="585" mass="63719" checksum="089EBCAD13E143AC" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ58</accession>
    <name>D7VQ58_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">infB</name>
        <name evidence="12" type="ORF">HMPREF0766_13112</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994059.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13112"/>
    <dbReference type="EnsemblBacteria" id="EFK55909">
        <property type="protein sequence ID" value="EFK55909"/>
        <property type="gene ID" value="HMPREF0766_13112"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0532">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006301_0_1_10"/>
    <dbReference type="OrthoDB" id="347113at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="523"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="108"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="189"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="298"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="532"/>
            <end position="539"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="579"/>
            <end position="583"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="633"/>
            <end position="636"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK55909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1024" mass="110908" checksum="05E116457158FFA1" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ92</accession>
    <name>D7VQ92_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994105.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13146"/>
    <dbReference type="EnsemblBacteria" id="EFK55943">
        <property type="protein sequence ID" value="EFK55943"/>
        <property type="gene ID" value="HMPREF0766_13146"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50348YX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2048228_0_0_10"/>
    <dbReference type="OrthoDB" id="2040415at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="122" mass="14153" checksum="CC28E454EFF63A20" modified="2010-10-05" version="1">MSGQNLEIQITISNNELRSIQEDPQQLITHIPSENWEALKSGIVDQLTDRDGAPQLDQIRIQNFRWNENSHKGSFRMQFLINRHFCCSDTEACAMDYVDWNFVYNAGLLSAEANYVNWTLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQM1</accession>
    <name>D7VQM1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrophobic domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994385.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13275"/>
    <dbReference type="EnsemblBacteria" id="EFK56072">
        <property type="protein sequence ID" value="EFK56072"/>
        <property type="gene ID" value="HMPREF0766_13275"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1808">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032897_0_0_10"/>
    <dbReference type="OrthoDB" id="1371086at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005240">
        <property type="entry name" value="DUF389"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20992">
        <property type="entry name" value="PTHR20992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04087">
        <property type="entry name" value="DUF389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="430" mass="48235" checksum="699D55BDC9507982" modified="2010-10-05" version="1">MIKLLRFIDLHNGEDAKEKVLENVTSNISFRGSNLWILACAIVVASVGLNVNSTAVIIGAMLISPLMGPIVGAGFALGTYDFALLKKSLKNLLIATLVSLSVSFIYFLLSPFKDAQSELLARTSPNIYDVLIAFFGGLVGVIAITRVEKGNPIPGVAIATALMPPLCTAGYGLAIGNLSYFAGALYLYSINCFFICISTFFIVKYLKYPKVKFVDKGREKRITRTITLLIMVMIIPSFYLAYVLLQQKKYTQLVDHFINTELVQKGYTVVYEKTSFNSNPKKIELAFLSRKFTPEEIKKLNLSLSGYGIFNTQLIIRQDSTDLKKDILEEINKRSENLSQKDIAIRNLNNELAMYKFDDPKLINEIDILFPEIKVYSVGKQLHVIRQDSTVVNTVLLYEAESPLSDENKSKLQTWLGSRINDPHIEIVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQS6</accession>
    <name>D7VQS6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_13330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994456.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13330"/>
    <dbReference type="EnsemblBacteria" id="EFK56127">
        <property type="protein sequence ID" value="EFK56127"/>
        <property type="gene ID" value="HMPREF0766_13330"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012730_0_0_10"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="233"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="364"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="153"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="582" mass="66633" checksum="6F06814FDCDD49F9" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQZ7</accession>
    <name>D7VQZ7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994545.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56198">
        <property type="protein sequence ID" value="EFK56198"/>
        <property type="gene ID" value="HMPREF0766_13401"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1577526_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="169" mass="19487" checksum="6DFC376E1F2725B7" modified="2010-10-05" version="1">MAKQAILLFSIFICLRSVRAQDLRAETLENQQWSWVSTLSAAGIGAGTTWTFLPDNRFEAKDWYSGGAYWTNIFTGKYHYDPETATVYLTYEKTTKQKIKLPKSCIRLVPDLQDTATFWPVFYDKWKKVKGEYRPAGEPLHSKSTSSSDKSAFYPAFQYHFEIKVLNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR11</accession>
    <name>D7VR11_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma factor regulatory protein, FecR/PupR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994570.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13415"/>
    <dbReference type="EnsemblBacteria" id="EFK56212">
        <property type="protein sequence ID" value="EFK56212"/>
        <property type="gene ID" value="HMPREF0766_13415"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050192_1_0_10"/>
    <dbReference type="OrthoDB" id="1381035at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032508">
        <property type="entry name" value="FecR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16344">
        <property type="entry name" value="DUF4974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="178"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4974" evidence="3">
        <location>
            <begin position="320"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="387" mass="44014" checksum="6E37F93D30610C1C" modified="2010-10-05" version="1">MMNPTQIEELIRKCLNGEATDKEQQLLNSYLEQISQHDLPVSEDRLSDMKQESWTKLQQQFAGNEPLKQKKSTKRWLWPAVAAAVVLITATGLLFLRSPKIDKQPLTAKKVSADTVVYPAADKAYLVLANGGTIDLETPENAQKEVKQQLDANINIDKGMISFGNTNKNKEAVGLYQTLVVPAGATYKLTLSDGTRVWMNAASRLKFPLGFEKDRRLVEMDGEAYFEVAKDKDRPFIIKSRRQEVKVLGTSFNMTDFANDKNSRTTLVEGSVEITNHKTNQKLYMKPGEQTVAGEQFRKMKVDPSPYIAWKNGYFDFTESNSLVEVMKQVERWYNVKVIFTNPNENRSWAGKMKRNMTLNELVGQLNFTGIKCEIENRNTIKNLIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR16</accession>
    <name>D7VR16_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994575.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13420"/>
    <dbReference type="EnsemblBacteria" id="EFK56217">
        <property type="protein sequence ID" value="EFK56217"/>
        <property type="gene ID" value="HMPREF0766_13420"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9D3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_642355_0_0_10"/>
    <dbReference type="OrthoDB" id="703808at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107178" evidence="1">
        <location>
            <begin position="22"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="427" mass="45864" checksum="8FD1AC262A7A0EDA" modified="2010-10-05" version="1">MKKRNLIGCIALGVLSLWATACSKNDNPTPPVEEASSRYVLITLADRVSGNKGGFISSFATYPTGVISNATANSLEGQGMGGWRVHNNMIFKMFSTAGYISGIEKIEVSKDGKVTAGKFISSKIPTEAAKYFGTGNLVIQNDNAGYYWDAAEPLKVQKFNPATMVNTGSIDLSAAVNARGKDEALIKFRAAGQKFLAIKAGKLYVNLTYAKNDASQVGFFDDFYTDVYLAVVDIATGTYEKTITIKETGSIAYINENHMYDFDTNGDLYIVTQGRTAVGGKSKIVRIKAAETDIDSSWELKFSDFRAADDGKFTNVFAKDGRLIFTLNTEKLTGGATGNINSEDIWKFYSLNVSDRKFNAIAGVPTGTNPGAAMVAVEVDGKILLRGATKAGENGYYEYNAANNTATSSFSVNVGGAVSGFVKVQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR20</accession>
    <name>D7VR20_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fetB</name>
        <name evidence="2" type="ORF">HMPREF0766_13424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994582.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13424"/>
    <dbReference type="EnsemblBacteria" id="EFK56221">
        <property type="protein sequence ID" value="EFK56221"/>
        <property type="gene ID" value="HMPREF0766_13424"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_3_1_10"/>
    <dbReference type="OrthoDB" id="1942521at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01140">
        <property type="entry name" value="FatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033870">
        <property type="entry name" value="FatB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="51"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="310" mass="33900" checksum="75BA8CB547C09857" modified="2010-10-05" version="1">MNKLIKNISCIILLAVAASCNSSKKNDGTATDSITVEHKLGKAQVVASPSHIVVFDIGALETLDQLGIPVAGVPKDNIPDHLIKYKNDEAVANVGSVKEPNYEKINALNPDLILISSRQEKFYDELNKIAPTVFVGVDDKDYMSSFRKNTLLIGQLVGKEAEAKSKLDAIDEKLKTAQGQLKGDNHKALIILHNNGRFSAYGKGSRFGFIHDVLGVKPAQEQLEVAIHGQKISNEFIAETNPDYLFIIDRNAVVAGKAGNKSEIENKLIQQTNAYKNGKLIYLNPQIWYLSGGGITSTDMMIDEIIKALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRB2</accession>
    <name>D7VRB2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YceI-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994698.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56313">
        <property type="protein sequence ID" value="EFK56313"/>
        <property type="gene ID" value="HMPREF0766_13516"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071003_2_2_10"/>
    <dbReference type="OrthoDB" id="1767227at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107193" evidence="1">
        <location>
            <begin position="24"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="YceI" evidence="2">
        <location>
            <begin position="28"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="195" mass="21252" checksum="7FE6C30976D5B324" modified="2010-10-05" version="1">MKSKIFSILLLTVINSFSILTYAQKTETYRVDGSKSSILWKGDKVSGSHTGTVDLTTGTLDFTGKKLTGGGFVINMASIKDADKSAGLEKHLKADDFFGVEKFPTAHFIIKKVEGSGNNVNITGNLTLKGVTQSISFPATITWNSDKTISATADKITVDRTKFGIQYKSKSIFSDIGDKFIYDEFTLSVKLLAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRC5</accession>
    <name>D7VRC5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4401 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994712.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13529"/>
    <dbReference type="EnsemblBacteria" id="EFK56326">
        <property type="protein sequence ID" value="EFK56326"/>
        <property type="gene ID" value="HMPREF0766_13529"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZCHA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1569714_0_0_10"/>
    <dbReference type="OrthoDB" id="1258345at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025513">
        <property type="entry name" value="DUF4401"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14351">
        <property type="entry name" value="DUF4401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4401" evidence="2">
        <location>
            <begin position="44"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="170" mass="18754" checksum="72D9291D0848E15A" modified="2010-10-05" version="1">MKNKEQIIEVLDYIRSKRENKESFVCDEEAIAASYQKSGYSESLAIKILSIFGGLLASLAFVGFLLISGLYDSGIGLVILGFVCIVIAVLVNKKSDKIILDTVTVLFYIIGFVLMTMGFNKFKMEDSSILLIFILIASCSLMIVHNYILSFISILILNGCIFGLILTNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRF3</accession>
    <name>D7VRF3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAAX amino terminal protease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994748.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13557"/>
    <dbReference type="EnsemblBacteria" id="EFK56354">
        <property type="protein sequence ID" value="EFK56354"/>
        <property type="gene ID" value="HMPREF0766_13557"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097145_0_0_10"/>
    <dbReference type="OrthoDB" id="1623593at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="232" mass="25940" checksum="E6486E2C79A8C7F5" modified="2010-10-05" version="1">MKNKVNYLAVLTFYIIAVALRYLTNKTDLLEDVPGSFIKVLLQASGPAIGALVVFYVFKIKPVLTLKGNYKSILIPFLLYWALPIVLILGVEYFIKGTVSFAAISAILIYGLLEEIGWRGFLQRELKPLPEFLNILLVATLWFIWHLNFDLTSSNLLFFGILVLGSWGIGKVADNTFSLLAVSAIHSLNNFFPEMNTTKICILLILLSVWGTALVIRKRNVKNKGSEESVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRL7</accession>
    <name>D7VRL7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, 2OG-Fe(II) oxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994844.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13621"/>
    <dbReference type="EnsemblBacteria" id="EFK56418">
        <property type="protein sequence ID" value="EFK56418"/>
        <property type="gene ID" value="HMPREF0766_13621"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048788_5_2_10"/>
    <dbReference type="OrthoDB" id="1391445at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035552">
        <property type="term" value="P:oxidative single-stranded DNA demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="PTHR31212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="104"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="206" mass="24003" checksum="DE3BD26E06A4E344" modified="2010-10-05" version="1">MKLFEDQSYKSRNLLPQDGEVYYYGTVLSVQEASEYYERLLQHIAWKNDQAVIFGKHIETKRKVAWYGDETFSYTYSNITKSALPWTEDLLKLKQIAEKHTGEKYNSCLLNLYHSGEEGMAWHSDGEKDLKKNGAIASMSFGAERKFAFKHKETKQMIAMVLEHGSLLVMKGTTQTHWMHRLPPTKRIFGPRINLTFRTIVKDTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSD7</accession>
    <name>D7VSD7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995515.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13891"/>
    <dbReference type="EnsemblBacteria" id="EFK56688">
        <property type="protein sequence ID" value="EFK56688"/>
        <property type="gene ID" value="HMPREF0766_13891"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50336Q6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123234_0_0_10"/>
    <dbReference type="OrthoDB" id="1833498at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025409">
        <property type="entry name" value="DUF4303"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14136">
        <property type="entry name" value="DUF4303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="185" mass="21906" checksum="B409F630BC379AB8" modified="2010-10-05" version="1">MNLDFEKLAIQIEAATRKTFQEMVASHAGENIYAFALYSDGGAMTVCPSINTMDFLATRPQDDLTYYTFEPAEWCYEGSRPGDGFSAISHQLYEAIEEDQEEVDDDDNDEEFEEFQQTLYQTCFDVLLKLKQENFFKNLVRKDIFLMFSVTDYEFDRNKLKEMIILLNDNPYQQEYLDWMKTWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSR4</accession>
    <name>D7VSR4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0502 protein HMPREF0766_14018</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0502 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995737.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14018"/>
    <dbReference type="EnsemblBacteria" id="EFK56815">
        <property type="protein sequence ID" value="EFK56815"/>
        <property type="gene ID" value="HMPREF0766_14018"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057831_1_0_10"/>
    <dbReference type="OrthoDB" id="1721848at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01584">
        <property type="entry name" value="UPF0502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007432">
        <property type="entry name" value="DUF480"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38768">
        <property type="entry name" value="PTHR38768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04337">
        <property type="entry name" value="DUF480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="180"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="216" mass="24292" checksum="272E3B3F1597E14F" modified="2010-10-05" version="1">MENKSLPQLSAEELRVLGSLLEKSKTTPEYYPMTLNGLQTACNQKTSRKPVVNYDEPTLIAALDALKKRGLVSTVVGGGSRVTKYKHNLAIQFPLIPSDLAVLCLLILRGPLTAGEINSNSGRLHEFEGLEDVQEHLNKLSEGEIEYVKQLPKRPGQKEVRYVHLLGEVNEEDYDEPVSNGVQQSQVKELENRVLVLEEQLQQLRAEFDSLMQELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSR7</accession>
    <name>D7VSR7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995742.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14021"/>
    <dbReference type="EnsemblBacteria" id="EFK56818">
        <property type="protein sequence ID" value="EFK56818"/>
        <property type="gene ID" value="HMPREF0766_14021"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_24_0_10"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043906">
        <property type="entry name" value="Gfo/Idh/MocA_OxRdtase_bact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19051">
        <property type="entry name" value="GFO_IDH_MocA_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="45"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C2" evidence="2">
        <location>
            <begin position="169"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="422" mass="47788" checksum="5D32FFF6580EF185" modified="2010-10-05" version="1">MKKQENSRREFLKKSIIGAAAFTIVPRFVLGGQGYLAPSDHLTKGVIGVGSMGRGHFAYAGTKTVAICDVDTRHLAIAQKTLGGGVREYHDFRELIKSPEVDIVHIATPPHWHGLMAVEAARAGKDIWCEKPMTRTIGEGQKVKEAVKQHGNIFRLNTWFRFEDNFYGMQVPVRKIKKLVDTGMLGWPLKVTISKHTGFDWKFFWIGKQNLPVEQVPAELDYDMWLGPAPYKPYSTHRTHLTFRGYWDYDGGGLGDMGQHYLDPVQYFLGKDEESPVSIEVDAPQQHNDAVGTWRRITYTYADGCQIILDGEGKDEGLAYIEGPKGKLYKGFVSDIPDLERKLSQYPEPAPQITNFLESVRTRQKFALNEENGYRSCTLVNLGLIALRLNRSLKFDSDKQVFINDEGANRLIHQPMRGPWTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSS2</accession>
    <name>D7VSS2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphodiester phosphodiesterase family protein</fullName>
            <ecNumber evidence="3">3.1.4.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glpQ2</name>
        <name evidence="3" type="ORF">HMPREF0766_14026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.46" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14026"/>
    <dbReference type="EnsemblBacteria" id="EFK56823">
        <property type="protein sequence ID" value="EFK56823"/>
        <property type="gene ID" value="HMPREF0766_14026"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_3_1_10"/>
    <dbReference type="OrthoDB" id="1542724at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107541" evidence="1">
        <location>
            <begin position="23"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="37"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="305" mass="34952" checksum="737BE5D5C79777BC" modified="2010-10-05" version="1">MKFYFFALCGLALTLGFSSCSMLNKKNQLMNDRFPDFSAEAHRGGRGLYPENTIEAMKMTIEHMPHITTLEMDCHITADKKVVVTHDDYLNPKYIRYADGKDIPADKKDLKIYKFDYNELKTYDTGSKLYSDFPDQLKLKTHIPLLSELIDAAEAEAKLHRKSPMFYNIETKSSPKGDNILHPQPSTFVDLMVEVIMNKGIGSRTVIQSFDKRTIQYLNKMYPQLKSSYLIDGKNKQSVEELINDLGFTPFIISPNYSLVTKEFVADCHARGIKVIPWTANTKEEIKRLKKLKVDGIISDYPNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSW1</accession>
    <name>D7VSW1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995854.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14065"/>
    <dbReference type="EnsemblBacteria" id="EFK56862">
        <property type="protein sequence ID" value="EFK56862"/>
        <property type="gene ID" value="HMPREF0766_14065"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033227_0_0_10"/>
    <dbReference type="OrthoDB" id="1439085at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033922">
        <property type="term" value="F:peptidoglycan beta-N-acetylmuramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008302">
        <property type="entry name" value="NamZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42915">
        <property type="entry name" value="PTHR42915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07075">
        <property type="entry name" value="DUF1343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016719">
        <property type="entry name" value="UCP016719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="407" mass="45805" checksum="0D6F9112FB09A882" modified="2010-10-05" version="1">MKQIPVFLSVVCLFLFCKSEVDAQQKLVYSNDKIKTGAEQTEKYVDYLKGKRVAILGNQSSVIGKTHLVDSLLALKINIVKIFGPEHGFRGNASNGTEVSDEVDTKTGIRIISLYGDRRKPSAKDLADVDLFIFDVQDMGVRFYTNINTLRDIMEACADNGKELMILDRPNPNAYLIDGPILDMKHKSGIGQFPVPVAHGMTIAEFAQMINGEKWMKAKTTCKLKIIPVSNYNHSMLYKLPVNPSPNLNTEESILLYPSTCLFEGTKLNHGRGTDYPFTVIGSPVYKGIYSFSFTPVSKKGMSESPLFMNQVCYGLDLRKVDLAKLVASKKLNLDWMKELYRKSPEKSAFFDRSFSTQIGSIETLAGVSDFRKQIESGASDQEIRKSWEPGLTNYKKMRKKYVIYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT45</accession>
    <name>D7VT45_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996027.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14149"/>
    <dbReference type="EnsemblBacteria" id="EFK56946">
        <property type="protein sequence ID" value="EFK56946"/>
        <property type="gene ID" value="HMPREF0766_14149"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9HA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1304222_0_0_10"/>
    <dbReference type="OrthoDB" id="912299at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="211" mass="23486" checksum="23D55050A93C35DF" modified="2010-10-05" version="1">MEIVIVICLLIVIALLLQDKIVIKKRSEQKPTKGKINPHLPDIMGQPKPKLSHSVPNTANESQIEEVEINLDNLDIEYDENENVSIQIPQEELDEVFSNIPDLEDEEEDWNRYGIPNGDDGFAQGVTFEELSSVGVLLQKEKLETAQKETAVAIVQKLQGTELFSLLENSVADASRKIAELLDSSLSTETEPGSSTLRKNDLGNFDIGEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT73</accession>
    <name>D7VT73_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Antioxidant, AhpC/TSA family</fullName>
            <ecNumber evidence="5">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_14177</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.15" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996087.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14177"/>
    <dbReference type="EnsemblBacteria" id="EFK56974">
        <property type="protein sequence ID" value="EFK56974"/>
        <property type="gene ID" value="HMPREF0766_14177"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_381255_0_0_10"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107270" evidence="3">
        <location>
            <begin position="20"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="588"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="726" mass="83616" checksum="38E8BB7A45BABB3E" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT84</accession>
    <name>D7VT84_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996118.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14188"/>
    <dbReference type="EnsemblBacteria" id="EFK56985">
        <property type="protein sequence ID" value="EFK56985"/>
        <property type="gene ID" value="HMPREF0766_14188"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50337Z0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149369_0_0_10"/>
    <dbReference type="OrthoDB" id="1903250at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107561" evidence="1">
        <location>
            <begin position="23"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="141" mass="15858" checksum="BCC2483E631201D3" modified="2010-10-05" version="1">MKNAIKSIATALILVTSLSAFAGENTNPVKTNSVSTVKSFLEATTLGNLNFNNQLFAKDFEYYTASKPNEKFNKNQYTEFLKNTKGLQYDCITSYQVLDENSDICVAKATMAFKSFTRVDYITLTRSQDVWKVSKVVTTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT95</accession>
    <name>D7VT95_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_14199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996152.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14199"/>
    <dbReference type="EnsemblBacteria" id="EFK56996">
        <property type="protein sequence ID" value="EFK56996"/>
        <property type="gene ID" value="HMPREF0766_14199"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_1_3_10"/>
    <dbReference type="OrthoDB" id="554994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107365" evidence="5">
        <location>
            <begin position="22"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="SusD-like_3" evidence="7">
        <location>
            <begin position="87"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="6">
        <location>
            <begin position="296"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK56996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="457" mass="51594" checksum="401C9CF6798BF969" modified="2010-10-05" version="1">MKRSFKYIFAGFVLLMTTACSDSLLDKDPISNFSGQGYYKKPSDAQAGVNGIYNSMQSLFRLNFAYWGEGRADNVTTRHSGDPFALQQNVLTPIINSARWDNFYTLISRANYAIKYTPQVFGEGESELKKQLLGQSHALRAIAYFYLVRIWGEVPLITEPYESVEQDLFVKQNTTAEVLAKVEEDLLFATENCASSYSGARNRVLITKGAAYAYLTQLYMWQKKYDKAIAAAQNILGDPQYSLVAMSDWNDIFVKGSSTESIFEVGYNETQTNGLRILYAIGSDSDYVPSTSFIASIEQGDLRKARIYDVTQVQPRKIWKFFGQGFNDESADPSSNNIVLTRLADIILLKAEAHAQLQQPTEALELLNRIRRRAGLSVMDEASANNLYGNLVNAILHERSIELCFEGHRWFDLVRTGKAISTMKPINGLADERNLVWPIHESAVLRNPNLNQNEFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTB0</accession>
    <name>D7VTB0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996192.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14214"/>
    <dbReference type="EnsemblBacteria" id="EFK57011">
        <property type="protein sequence ID" value="EFK57011"/>
        <property type="gene ID" value="HMPREF0766_14214"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153788_1_3_10"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="93" mass="10475" checksum="C999CCE67AFC3498" modified="2010-10-05" version="1">MKRQPVLPKFQAILEQMGENIKLARKRRKLTAVQVAERAGIARSTLYLIEKGDSSVAMGAYFNVLRVLGLQDDFLKLAADDVFGRKLQDLDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTI8</accession>
    <name>D7VTI8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996391.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14292"/>
    <dbReference type="EnsemblBacteria" id="EFK57089">
        <property type="protein sequence ID" value="EFK57089"/>
        <property type="gene ID" value="HMPREF0766_14292"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032SGC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098578_1_0_10"/>
    <dbReference type="OrthoDB" id="1739403at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107667" evidence="2">
        <location>
            <begin position="23"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="161" mass="19865" checksum="493ABE79C5C91C96" modified="2010-10-05" version="1">MKKLLYITLLIGGIFSFTPSQAQVRINVNIGSQPLWGPVGYDYVRYYYMPEMDVYYDVVHRRYTYYHGNRWVTRSSLPSKYRRYNMYRTYKVVVNDHNPWHRHNHYHERYHRYSGNYSQVNLRDGRGRSDRHDRDRYDRHDRKDNHKGNKHRGKNKGRHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTN7</accession>
    <name>D7VTN7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LytTr DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_14357</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001675.1">
        <property type="nucleotide sequence ID" value="NZ_GL379777.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14357"/>
    <dbReference type="EnsemblBacteria" id="EFK55796">
        <property type="protein sequence ID" value="EFK55796"/>
        <property type="gene ID" value="HMPREF0766_14357"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_14_1_10"/>
    <dbReference type="OrthoDB" id="1958442at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK55796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="250" mass="29384" checksum="CE207332205E1EC8" modified="2010-10-05" version="1">MNIIIIEDEMPSARLLKRKVENMGYTVTALLHSVEDAKAWLLSNPEPELIFLDIQLSDGLSFEIFEEVNVQSAIIFTTAYDEFVLRAFKMNSIDYLLKPIIEEELKFAFDKFLKLQHSKEAVDMNEIRSLLKLTKKESYKERFTIKIGQTIKVIDIQDIACIYSEHKGTYLWTRQGNNYLLDITLDKVEKMIDPNRFFRISRSHIIQIDSIKEIAVHSNSRLRIYLQPDPDQEMIVSRERVSDFKSWLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGB6</accession>
    <name>D7VGB6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_10035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10035"/>
    <dbReference type="EnsemblBacteria" id="EFK60091">
        <property type="protein sequence ID" value="EFK60091"/>
        <property type="gene ID" value="HMPREF0766_10035"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_3_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="210"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK60091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="330" mass="37133" checksum="0CEFDB5680776A14" modified="2010-10-05" version="1">MMSREKRLVLLSLLTGLVLMLIKFTAYLITDSNAIFTDAAESIVNVVASGFAFYSIYLSARPRDENHPYGHGKVEFFSVFVEGGLIFIAGLIILVKAVYNLFFPNELFNLSEGIGLIALTGLINFIVGLYLVKRGRALKSLTIEADGKHLQVDAYSTFGLITGLLLITWTGLVWIDIVISLMLGAFILFNGYRLLRKSIGGLMDESDLELVNEVVDTLNTVRRTEWIDIHNLRVQRYGNELHVDCHLTLPRYYKLDRVHDEISALDNIVNAKLSTRTEFFVHADPCLPECCSYCGIADCPVRSAAFTNDIQWDIQNVTRNKKHFESIDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGD8</accession>
    <name>D7VGD8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10057"/>
    <dbReference type="EnsemblBacteria" id="EFK60113">
        <property type="protein sequence ID" value="EFK60113"/>
        <property type="gene ID" value="HMPREF0766_10057"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044440_2_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005672221" evidence="1">
        <location>
            <begin position="24"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="217" mass="24713" checksum="67E3A5ED5F88409B" modified="2010-10-05" version="1">MKFQPKKCIVALFLVVASGYVNAQEQIIKDNLQIGEYDYSIELGPGKRLYFGGISESTDFLSMYRYNEAFNSSHLRVEIGDDHGSPGDRFVVGAKDYRTGLYHPYFQVLANGNIGVGMNEPAERLSVNGNIRTKEIKVEAANWPDYVFKKDYKLRSLSELNTYIEEHGHLPDIPKAAEVEKEGVSLGEMNKLLLKKVEELTLYILNQEKRISELEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGE1</accession>
    <name>D7VGE1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RHS repeat-associated core domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10060"/>
    <dbReference type="EnsemblBacteria" id="EFK60116">
        <property type="protein sequence ID" value="EFK60116"/>
        <property type="gene ID" value="HMPREF0766_10060"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004466_1_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045619">
        <property type="entry name" value="DUF6443"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20041">
        <property type="entry name" value="DUF6443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6443" evidence="1">
        <location>
            <begin position="132"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1179" mass="132439" checksum="285EC51942CD1256" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGH6</accession>
    <name>D7VGH6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002047.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10095"/>
    <dbReference type="EnsemblBacteria" id="EFK60151">
        <property type="protein sequence ID" value="EFK60151"/>
        <property type="gene ID" value="HMPREF0766_10095"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105794_0_0_10"/>
    <dbReference type="OrthoDB" id="1792718at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="225" mass="26255" checksum="1BEDE949547C18BF" modified="2010-10-05" version="1">MDIPHQHQTEPATSVPPQEKTTQSPYDYPQILRMLEEKGKELFGSSFHFQTQDHPLIIQLTAYFLRDQLTCDQAHISLDKGLLLSGPIGCGKTTLITLMRYITQPVNKYFIKSCRDISFEFIQDGYEVIHRYSKGKLYEPSTRNYCFDDLGVENNLKYYGNECNIMAEIILSRYDLYISRQLQTHITTNLSASEIEAYYGNRVRSRMRELFNLIAFPNDARDKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGQ1</accession>
    <name>D7VGQ1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK59253">
        <property type="protein sequence ID" value="EFK59253"/>
        <property type="gene ID" value="HMPREF0766_10170"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3276841_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="41" mass="5122" checksum="0B7CC7D42C78F5BC" modified="2010-10-05" version="1">MVNTVNKQFKKELFHLHYTLFDHFKYKNEHICLSYKTYSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGW0</accession>
    <name>D7VGW0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK59312">
        <property type="protein sequence ID" value="EFK59312"/>
        <property type="gene ID" value="HMPREF0766_10229"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3189163_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="46" mass="5320" checksum="3493C71069E5858A" modified="2010-10-05" version="1">MLSIALADNVQLLRYNNNPHYKSNDSGIEATKISNLIGFRFHWPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH93</accession>
    <name>D7VH93_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dGTPase</fullName>
            <ecNumber evidence="2">3.1.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dgt</name>
        <name evidence="2" type="ORF">HMPREF0766_10362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.5.1" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997250.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10362"/>
    <dbReference type="EnsemblBacteria" id="EFK59445">
        <property type="protein sequence ID" value="EFK59445"/>
        <property type="gene ID" value="HMPREF0766_10362"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028163_2_0_10"/>
    <dbReference type="OrthoDB" id="370035at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023293">
        <property type="entry name" value="dGTP_triP_hydro_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027432">
        <property type="entry name" value="dGTP_triphosphohydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006261">
        <property type="entry name" value="dNTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020779">
        <property type="entry name" value="dNTPase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF32">
        <property type="entry name" value="PTHR11373:SF32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01353">
        <property type="entry name" value="dGTP_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="65"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="454" mass="51367" checksum="41AC3CDD6883C996" modified="2010-10-05" version="1">MSENMQMNWKQLLSAKRWGYEDRINKDHLEARSEFQRDYDRLIFSSPFRRLQNKTQVFPLPGAVFVHNRLTHSLEVASVGRSLGRLFYAKMKEANPDVDEDYPFLQEVGNIVSAACLSHDLGNPAFGHSGESAISTYFTEGEGRKFQEQVTAEEWADLTHFEGNANALRILTHPFNGKDDKGFALTYTSLASIVKYPCAAIDGHIKKNHHRKKYGFFTAERESFAKIATELGLLQDPTNPKGYLRHPLVYLVEAADDICYNIIDLEDAHHLKILSYKEVEELLLPLCGGENLRNRLDSLNDTASRVALLRAKAINTLIHGCVDVFFKEQDKFLAGTFPMALMDALEDDVVQQMKKISKISVAQIYNAPTVVQIEVAGYKVMNALLAEFVPAYLKKNKNGYDQKLVALVPNQFYTTNDDAYSKIRSILDYVSGMTDVYAIDLYRKIKGITIPSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH97</accession>
    <name>D7VH97_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10366"/>
    <dbReference type="EnsemblBacteria" id="EFK59449">
        <property type="protein sequence ID" value="EFK59449"/>
        <property type="gene ID" value="HMPREF0766_10366"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3048117_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="54" mass="6343" checksum="C3113F563D7219F0" modified="2010-10-05" version="1">MINWHDKVYFKNMKQYSVKPAKGLFGARKEMPNIGQKQHLQSSLLLKRSCPRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH98</accession>
    <name>D7VH98_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAH family protein</fullName>
            <ecNumber evidence="2">3.7.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fahA2</name>
        <name evidence="2" type="ORF">HMPREF0766_10367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997260.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10367"/>
    <dbReference type="EnsemblBacteria" id="EFK59450">
        <property type="protein sequence ID" value="EFK59450"/>
        <property type="gene ID" value="HMPREF0766_10367"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_3_3_10"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="84"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="327" mass="36388" checksum="4A16A6D577EA6B84" modified="2010-10-05" version="1">MRLVTCEYDNKEQLGFILDDQIYICSQTAPGLPVSMNDFLEGGQQSMQAMSRTVELAKKGKFSNIALDSRHIKLLAPVPYPSSFRDAYAFRQHVSTSRRNRGLEMIPEFDKFPVFYFSNHRAVMGPGSVSCMPLHFDQLDFELEVAVVLNKRGKNIPASEADQYIAGYMIMNDLSARNLQMEEMKLNLGPAKGKDFATMTGPYLVTKDELEPYKIATPEGHTGDTYNLHMSCAVNGKQVSAGNLADMNWTFAEIIERVSYGVEVFPGDLIGSGTVGTGCFLELNGTGKRNDPNYQVQWLQPGDHISMQVTGLGQLDNTVVLEPINKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHG2</accession>
    <name>D7VHG2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetylglutamate kinase</fullName>
            <ecNumber evidence="7">2.7.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetyl-L-glutamate 5-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">NAG kinase</fullName>
            <shortName evidence="7">NAGK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">argB</name>
        <name evidence="9" type="ORF">HMPREF0766_10431</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetylglutamate kinase family. ArgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997430.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10431"/>
    <dbReference type="EnsemblBacteria" id="EFK59514">
        <property type="protein sequence ID" value="EFK59514"/>
        <property type="gene ID" value="HMPREF0766_10431"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0548">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053680_1_0_10"/>
    <dbReference type="OrthoDB" id="901370at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00082">
        <property type="entry name" value="ArgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="42"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="265" mass="28705" checksum="055457ABCD161CBA" modified="2010-10-05" version="1">MGVSTLNIIKIGGNVIDNEQDLNDFLEKFSALSGKKILVHGGGKIATRLAADLGIEANLIDGRRVTDAEMLKIVTMVYAGLTNKSIVSKLQNLNCDALGLSGADGDTIRTMKRPVKDIDYGFVGDIMHDSINTASIKKVLEAGFVPVFSAITHNGIGQLLNTNADTIASALAVALADLYETSLIYCFEKNGVLRDVKDENSVFERINAKDFEQLKKEGVIHTGMIPKLQNAFDAIRKGVKHVYVGNANNLHLFQQSHFGTCLVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHP9</accession>
    <name>D7VHP9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron chelate uptake ABC transporter, FeCT family, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hmuU</name>
        <name evidence="8" type="ORF">HMPREF0766_10518</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997613.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10518"/>
    <dbReference type="EnsemblBacteria" id="EFK59601">
        <property type="protein sequence ID" value="EFK59601"/>
        <property type="gene ID" value="HMPREF0766_10518"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_0_3_10"/>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="347" mass="36622" checksum="1447CFDEB8C53F21" modified="2010-10-05" version="1">MSGMKYILIYSLLSILLILVLIFSLGMGSIRIPSQDVVVILLQKLHLFSDRPMDELNANVIYQIRLPRILLGVLVGAALGVSGAAIQGVFRNPLAEPGLMGISTGASLFAAIVISFEAALAAAVSATFNSYMLAFAAFLGASLAVFFVYRISITDGKPHIATMLLAGIAINAFAGALTGLLSYLATEQQLRSITFWSLGSLAGANWDNIKVLFPCVLLPILALPFFGKKLNVFALGESQAEMMGVNTGKLKVLVITFSTLAVGAAVAFSGVISFVGLLVPHAIRLVGGVDNRYVLVGSALAGALVLTLSDLVARTIIQPLELPIGVITALLGTPVFLYILIRDKSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHS3</accession>
    <name>D7VHS3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PglZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997677.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10542"/>
    <dbReference type="EnsemblBacteria" id="EFK59625">
        <property type="protein sequence ID" value="EFK59625"/>
        <property type="gene ID" value="HMPREF0766_10542"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_527616_0_0_10"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013973">
        <property type="entry name" value="PglZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08665">
        <property type="entry name" value="PglZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="517" mass="60998" checksum="EDE76C3453AAD1F9" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI84</accession>
    <name>D7VI84_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD dependent epimerase/dehydratase family protein</fullName>
            <ecNumber evidence="2">5.1.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">wbpP</name>
        <name evidence="2" type="ORF">HMPREF0766_10703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998037.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10703"/>
    <dbReference type="EnsemblBacteria" id="EFK59786">
        <property type="protein sequence ID" value="EFK59786"/>
        <property type="gene ID" value="HMPREF0766_10703"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_10"/>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="322" mass="35796" checksum="8F26131F01764A0E" modified="2010-10-05" version="1">MSKILITGGAGFIGSNLTEYFLSKGHQVVVLDNFATGHRHNLEQHAHNTNFELIEGDIRNVSDCEKAVKGVDYVLHQAALGSVPRSIKDPQTSNEVNVSGFLNMLVAARDANVKRFIYAASSSTYGDSEALPKIEEKIGKPLSPYAITKYVNELYAEIFSKTYGLETIGLRYFNVFGRRQDPNGAYAAVIPLFVKQLMKHESPVVNGSGDYSRDFTYIDNVIQMNELAMNTVNSEAVNTVYNTAVGDRTTLNQLLAYLKDALSEYDSEIANVEVIHGPNRQGDIPHSLASVEKARRLLGYEPSHTIRSGLKEAVKWYWQNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIA9</accession>
    <name>D7VIA9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998088.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10728"/>
    <dbReference type="EnsemblBacteria" id="EFK59811">
        <property type="protein sequence ID" value="EFK59811"/>
        <property type="gene ID" value="HMPREF0766_10728"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030ZXN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153095_2_1_10"/>
    <dbReference type="OrthoDB" id="1802338at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="138" mass="15737" checksum="1975242336A4F7AB" modified="2010-10-05" version="1">MDEEQKFSLSGTFQKSKEYLDSQIELLKLKAIARGSRMLGSLILDISKVVLTLFIVFFLSLAFAFYLGELMNSNALGFLTTGGIFILLVVIVRLTETKLEAKFMDLSIRKLLGKWNEEDEEDVKSENGKRNEETFKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIR1</accession>
    <name>D7VIR1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998391.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10880"/>
    <dbReference type="EnsemblBacteria" id="EFK59963">
        <property type="protein sequence ID" value="EFK59963"/>
        <property type="gene ID" value="HMPREF0766_10880"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032WFK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109380_0_0_10"/>
    <dbReference type="OrthoDB" id="1478746at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="220" mass="23691" checksum="8CD4E3DA51AD300A" modified="2010-10-05" version="1">MKSYFKIISTLTLSAVLLSACGGNKKSEDGDTSTEEKGGITDVVSGVKNLNNLTDGAAKMEEVQNKLKGLTPLSNEELKSFFPETLEGLKRTSISVGNGEMYGNIATGNATYSDEAGKEITVKLMDGAGELGSGVVSLLVLGYQVESESENGNRVEKTGEFNGKRGKTEESKENDGTADYFVSSVSFLEKDRYNVELRGQHFSLAELQKAMDKLNYAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ14</accession>
    <name>D7VJ14_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002101.1">
        <property type="nucleotide sequence ID" value="NZ_GL379779.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10983"/>
    <dbReference type="EnsemblBacteria" id="EFK59149">
        <property type="protein sequence ID" value="EFK59149"/>
        <property type="gene ID" value="HMPREF0766_10983"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4818">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095018_2_1_10"/>
    <dbReference type="OrthoDB" id="2012653at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="121" mass="13798" checksum="76A071FE284F5C91" modified="2010-10-05" version="1">MVYTFGYINKIVMDKKTLSILSYVTIIGWIVAYVKNKDLQPKSDLVNYHLKQGFGFFILSVIINVALSVIVFIVPALTFLSYIGIILFILWIFGLINAVNEQKKPIPIVGKMFEGKFDFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ22</accession>
    <name>D7VJ22_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002117.1">
        <property type="nucleotide sequence ID" value="NZ_GL379779.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10991"/>
    <dbReference type="EnsemblBacteria" id="EFK59157">
        <property type="protein sequence ID" value="EFK59157"/>
        <property type="gene ID" value="HMPREF0766_10991"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121830_0_0_10"/>
    <dbReference type="OrthoDB" id="1031920at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="98"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="190" mass="22091" checksum="EFD06893181E2385" modified="2010-10-05" version="1">MTELNIKNMVCDRCIHVVKGELKKIGYETADVSLGYVKIDQNLNKESREKIGNLLSSFGFELLDSDKAKMIERIKNLVIMRIHHTDELDLKVNWSTLLSAELNHDYSFISSLFSSVEGVTLEQYIIRQKIERVKELLFYDELSLKEIAYKLDYSSVQHLSTQFKKITGQTPTDFKMKRAERLPRQAIDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ23</accession>
    <name>D7VJ23_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002119.1">
        <property type="nucleotide sequence ID" value="NZ_GL379779.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10992"/>
    <dbReference type="EnsemblBacteria" id="EFK59158">
        <property type="protein sequence ID" value="EFK59158"/>
        <property type="gene ID" value="HMPREF0766_10992"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026364_0_0_10"/>
    <dbReference type="OrthoDB" id="305021at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107286" evidence="1">
        <location>
            <begin position="21"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="657" mass="76274" checksum="07C96178F433EC01" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ33</accession>
    <name>D7VJ33_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0766_11002</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002140.1">
        <property type="nucleotide sequence ID" value="NZ_GL379779.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11002"/>
    <dbReference type="EnsemblBacteria" id="EFK59168">
        <property type="protein sequence ID" value="EFK59168"/>
        <property type="gene ID" value="HMPREF0766_11002"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_21_1_10"/>
    <dbReference type="OrthoDB" id="626183at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005580">
        <property type="entry name" value="DbpA/CsdA_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03880">
        <property type="entry name" value="DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="34"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="216"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="539"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="539"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK59168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="603" mass="67721" checksum="EDD1D418FABC48C0" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ49</accession>
    <name>D7VJ49_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HMPREF0766_11018</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002173.1">
        <property type="nucleotide sequence ID" value="NZ_GL379779.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11018"/>
    <dbReference type="EnsemblBacteria" id="EFK59184">
        <property type="protein sequence ID" value="EFK59184"/>
        <property type="gene ID" value="HMPREF0766_11018"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_0_10"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="220"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="284"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK59184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="437" mass="49009" checksum="AC016BAEA3433E2E" modified="2010-10-05" version="1">MALDVFWTLLLVLANGFFVAAEFAIVKVRASQIELQAKSGSKVAKVAKNITEHLDGYLAATQLGITLASLALGWIGERVMTDIVGNFFQFVGVDISAGWAKTGGHVLAFAIITILHVVLGELAPKSIAIQKPVATTMRLAIPLRVFYYLFIPFIWVLNGFANFLLKLIGIQPHSSESHHSSEELQYLLDKGKESGALDFSEHELIKNVFDFNERIVKNIMVPRTKIVAIDKDATADEFINTVTEEGYSRIPIYDDNIDQIVGIVHTKDILPIIVKGKEVVLKNIMRKPYFIPETKKINDLMAEFQLKRIQIAIVLDEFGGTAGMVTLEDIVEELVGEIQDEYDEETPVVERISETEYMIDAGASVHDVNEYLPLELPESSDYDTMAGLVSDLFDKIPEVGEYKELYGYTFTIMKKTQQNIEFVKLELIETPHDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ90</accession>
    <name>D7VJ90_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, BlaI/MecI/CopY family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11059"/>
    <dbReference type="EnsemblBacteria" id="EFK58943">
        <property type="protein sequence ID" value="EFK58943"/>
        <property type="gene ID" value="HMPREF0766_11059"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119090_4_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="128" mass="14880" checksum="21E261623E290DF7" modified="2010-10-05" version="1">MFKSKITDMEKLTIQEEEAMLSIWQLNGGFIKEVLDNIKGSAVPYTTLASTIKNLERKGYVKAVKYANAKRYEPLITEEEYKKRFMSGFVGDYFKNSYKEMVSFFVKEDKLSASELEEIMDMIKNNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJK9</accession>
    <name>D7VJK9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SusD_RagB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11178</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000714.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11178"/>
    <dbReference type="EnsemblBacteria" id="EFK59062">
        <property type="protein sequence ID" value="EFK59062"/>
        <property type="gene ID" value="HMPREF0766_11178"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032RCN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_477915_0_0_10"/>
    <dbReference type="OrthoDB" id="445604at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107577" description="SusD_RagB domain-containing protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="6">
        <location>
            <begin position="345"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="541" mass="62362" checksum="71EDDF1538495127" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJL8</accession>
    <name>D7VJL8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl hydrolase, family 88</fullName>
            <ecNumber evidence="1">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000732.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11187"/>
    <dbReference type="EnsemblBacteria" id="EFK59071">
        <property type="protein sequence ID" value="EFK59071"/>
        <property type="gene ID" value="HMPREF0766_11187"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042785_0_0_10"/>
    <dbReference type="OrthoDB" id="982403at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="381" mass="44316" checksum="6AB62AD789511850" modified="2010-10-05" version="1">MKTNSLKSLFTILSVFFLTVQVSGQNFTSKKQVIKDLRLANDYFMKKWPDPTKNIITNKERTSNIWTRGVYYEGLLAFYGIDQQKRYYDYAVEWADFHKWLPVRGERYTRHADNQNCGQSYIDLYRIDPQPVRIAGIKENIDSVIRSGRVNDWTWIDAIQMAMPIFVKLGVTYNDPSYFDAMYKFYHHIKYKEAQHGLYNPKDQLWWRDKDFVPPYKEPNGEDCYWSRGNGWIAAALVRVLEELPKTDPHYQEYETDLKNLLAALVPLQRKDGFWNVSLHDPDHFGGKEASGTALFVYGMAWGINNGILDKKIYLPVVQKAWTALRKESLHKNGFLGYLQATGKEPKDGQPVTYTSVPDFEDYGLGCFLLAGTEIYKLVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJT8</accession>
    <name>D7VJT8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998617.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11257"/>
    <dbReference type="EnsemblBacteria" id="EFK58540">
        <property type="protein sequence ID" value="EFK58540"/>
        <property type="gene ID" value="HMPREF0766_11257"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2059934_0_0_10"/>
    <dbReference type="OrthoDB" id="1311928at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="119" mass="13335" checksum="58E1AE3A7D2B8C69" modified="2010-10-05" version="1">MKIPFLIAAVTLFSSCADFIEYPLEKEQVALLGPVDNFSTTDTLITFWWDTHQDAKAYRLQIVSPDFDKVGSDVIDTLVAGDKARLSLKAGAYTWRVRPENNGSAGIYTYRKLEIKATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJX7</accession>
    <name>D7VJX7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, NUDIX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998718.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11296"/>
    <dbReference type="EnsemblBacteria" id="EFK58579">
        <property type="protein sequence ID" value="EFK58579"/>
        <property type="gene ID" value="HMPREF0766_11296"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_3_1_10"/>
    <dbReference type="OrthoDB" id="1846332at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045830">
        <property type="entry name" value="AraR_wHTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19368">
        <property type="entry name" value="AraR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="221" mass="26141" checksum="F1D0BF94F75C1D5D" modified="2010-10-05" version="1">MFTNFTIDCVIFGFHDGYLKVLLTERNEYPFKDWWALPGFFVNNDEEMEDAVKRILYENTGLKDIYMEQLAALAGLKRHPQGRILTVAYFALMQLDHAKIKVKPVTSYMRQANWFSVHELPDLAFDHKQIIELSLEKLKRKIGYSPVAFELLPEKFTLTQLQLVYEAILGKKLDKRNFRKKMLNYGFLKELSEFQKGVSYRAARLYKLDKRKFHKAFSHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJY5</accession>
    <name>D7VJY5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998747.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11304"/>
    <dbReference type="EnsemblBacteria" id="EFK58587">
        <property type="protein sequence ID" value="EFK58587"/>
        <property type="gene ID" value="HMPREF0766_11304"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4856">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069602_0_0_10"/>
    <dbReference type="OrthoDB" id="992089at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="315" mass="36328" checksum="1F7A9AED85F71252" modified="2010-10-05" version="1">MALRRFNKSQKRKISIFLRCILISFIAWTLFAISNKYVYSMKAGIQYVNLPDNKAFHPLQSDTVSLKVEMSGWKLLLSRFRQDTANIQVDLSGLKNRNWIVFSNQIGFINRQFPNDKHVVSVSPDTLYFDFSKQTQRKVPIKAVYSVDFAKQYGIIGDTRSLPEYVTITGPLEDVANIESWETDTIRGTGINADIRTMAYLDRNQKANINVYPAYAEVTIPVGELTEKVMELPIKVENAEKYTSVRTLPTKVKVIILVSLKDYNKWTQRDFEAVVDIEDWEENRVPNLPVILTKIPPYCKIVSVEPQNVDFFIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK67</accession>
    <name>D7VK67_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998977.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11386"/>
    <dbReference type="EnsemblBacteria" id="EFK58669">
        <property type="protein sequence ID" value="EFK58669"/>
        <property type="gene ID" value="HMPREF0766_11386"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_6_10"/>
    <dbReference type="OrthoDB" id="1616572at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="304" mass="34902" checksum="E09A6E992D646B0D" modified="2010-10-05" version="1">MKKIRPTIVVFGCTGTVGREVMHQLTEYDCIVRGVLRHPDRMYPVRTDSRTSNITYVSADLNSIEQLQKACVGADALFLLTATSPQQVQYEINIIDAAKQSGIKRIVKLSAPVVQPAAHVEVSQWHNIIDDYLVQNMDEFCCLRPHSFMQNWERNTFTIQYFGKIYGTLGDAKRNYIDCRDVATVAIHYLLTPEQVKEGSVILAGPQAISNIEMADKLSHVTGRKIEYVNITADEFFSLLTRKAKLPEWLASHIVELDNLALHIPEPECDTITNLILRKPRIMDEYLQEYRYLFKRKPFWKLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKB5</accession>
    <name>D7VKB5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD/DEAH box helicase</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lhr</name>
        <name evidence="3" type="ORF">HMPREF0766_11434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999098.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11434"/>
    <dbReference type="EnsemblBacteria" id="EFK58717">
        <property type="protein sequence ID" value="EFK58717"/>
        <property type="gene ID" value="HMPREF0766_11434"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002025_0_1_10"/>
    <dbReference type="OrthoDB" id="35275at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026362">
        <property type="entry name" value="DEXH_lig_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017170">
        <property type="entry name" value="Lhr-like_ATP-dep_RNA_helic_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045628">
        <property type="entry name" value="Lhr_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19306">
        <property type="entry name" value="Lhr_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037307">
        <property type="entry name" value="Lhr-like_helic_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04121">
        <property type="entry name" value="DEXH_lig_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="24"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="239"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="807" mass="92175" checksum="777F325EE0990BF0" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKD3</accession>
    <name>D7VKD3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999154.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK58735">
        <property type="protein sequence ID" value="EFK58735"/>
        <property type="gene ID" value="HMPREF0766_11452"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032S97">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115019_1_0_10"/>
    <dbReference type="OrthoDB" id="946586at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02118">
        <property type="entry name" value="TIGR02118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107237" evidence="1">
        <location>
            <begin position="23"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="135" mass="14951" checksum="D7938E796DFA4443" modified="2010-10-05" version="1">MKTKTGLLIVMLALLISCQQSSAPSLAFHKKGMIKVTIFYPNGEGKTFDMDYYINKHMPLVQRVYGNALKGLTIDKGIGGGSPDTPAPYMAIGHLYFENIAAYEEGLKKNRETFAADFPKYTNVMPVVQISEVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKQ6</accession>
    <name>D7VKQ6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Polyphosphate kinase</fullName>
            <ecNumber evidence="6 7">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-polyphosphate phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Polyphosphoric acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ppk1</name>
        <name evidence="6" type="synonym">ppk</name>
        <name evidence="12" type="ORF">HMPREF0766_11575</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6 7">An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the polyphosphate kinase 1 (PPK1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="6 7"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999448.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11575"/>
    <dbReference type="EnsemblBacteria" id="EFK58858">
        <property type="protein sequence ID" value="EFK58858"/>
        <property type="gene ID" value="HMPREF0766_11575"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0855">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009678_5_0_10"/>
    <dbReference type="OrthoDB" id="76567at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009358">
        <property type="term" value="C:polyphosphate kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1840.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00347">
        <property type="entry name" value="Polyphosphate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003414">
        <property type="entry name" value="PP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041108">
        <property type="entry name" value="PP_kinase_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024953">
        <property type="entry name" value="PP_kinase_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036830">
        <property type="entry name" value="PP_kinase_middle_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025200">
        <property type="entry name" value="PPK_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025198">
        <property type="entry name" value="PPK_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036832">
        <property type="entry name" value="PPK_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30218">
        <property type="entry name" value="PTHR30218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02503">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13090">
        <property type="entry name" value="PP_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17941">
        <property type="entry name" value="PP_kinase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13089">
        <property type="entry name" value="PP_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015589">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140356">
        <property type="entry name" value="SSF140356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03705">
        <property type="entry name" value="poly_P_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PP_kinase_N" evidence="9">
        <location>
            <begin position="8"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase" evidence="8">
        <location>
            <begin position="121"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C_1" evidence="11">
        <location>
            <begin position="326"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C" evidence="10">
        <location>
            <begin position="497"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphohistidine intermediate" evidence="6">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="558"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="586"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK58858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="682" mass="79768" checksum="E9708FBCE7732A66" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKR5</accession>
    <name>D7VKR5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-70 region 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sigH</name>
        <name evidence="4" type="ORF">HMPREF0766_11584</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999461.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11584"/>
    <dbReference type="EnsemblBacteria" id="EFK58867">
        <property type="protein sequence ID" value="EFK58867"/>
        <property type="gene ID" value="HMPREF0766_11584"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_1_4_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="17"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="109"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="167" mass="19473" checksum="F45E613504EB11AD" modified="2010-10-05" version="1">MTKFEFNSMVIQQASSLKLYAKNFTRDQDDANDLVQDTLLKAVTYFGNFKEGTNLKGWLYTIMKNTFINNYRRIVKTNSFITKEEEITSANLFVSATHNDGENKFIMEDINKALTNLSDEYYIPFSMYFEGYKYHEISDHLNIPIGTVKTRIHVARKAMKKTLTAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKS1</accession>
    <name>D7VKS1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999467.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11590"/>
    <dbReference type="EnsemblBacteria" id="EFK58873">
        <property type="protein sequence ID" value="EFK58873"/>
        <property type="gene ID" value="HMPREF0766_11590"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_2_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plug" evidence="1">
        <location>
            <begin position="123"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1058" mass="117902" checksum="DD2C18DE395727A1" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKY8</accession>
    <name>D7VKY8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Siderophore-interacting FAD-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999640.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11657"/>
    <dbReference type="EnsemblBacteria" id="EFK58261">
        <property type="protein sequence ID" value="EFK58261"/>
        <property type="gene ID" value="HMPREF0766_11657"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2375">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040923_3_1_10"/>
    <dbReference type="OrthoDB" id="1630289at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="277" mass="31373" checksum="843DF5B2D9080238" modified="2010-10-05" version="1">MAAKTKSKSGQFEARVVEKIYLTPHLIRIILTSEDVPLYADATIGVNNKILIPPAGVDEIHFPTFDFETGKWLYPAPEVAPVVRTYTHRAIDVEKKQLVIDFVAHGEAGPASRWAIHAQKGDLLGIMMHMDPSVLYAEADWYFLIGDATAIPVISAILEDLPANAHAEVLLEVHGKEDEIEPETNASYRIHWLHNINPEKSSDLASFARSIEIPQDVRKFAYVATEYRTVKELRNYFRKELEWTKDELYAYSYWKAGQTEDGSAADRHEESYGKQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL45</accession>
    <name>D7VL45_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999760.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11714"/>
    <dbReference type="EnsemblBacteria" id="EFK58318">
        <property type="protein sequence ID" value="EFK58318"/>
        <property type="gene ID" value="HMPREF0766_11714"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_2_10"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="183"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="282" mass="33508" checksum="42FD5BD948E2C3DB" modified="2010-10-05" version="1">MVTKETFATLELKEFQFDPRSDYSLLYHGSHGRNKIEKAHKHDFYLLFLIEKGNGIHSIDFVDYPVSDFQIHILFPDQIHKWDLGEETSGYQLMISKRVFETFSTSMQFSFLLYQSHPVLQLSQPLFHDILFEYESLKRELALHPVYWDIVYSRSKLITQLVNREIERKFDDISLYRTNPILLRYHSLIDYHFKEEKTVTFYADKLNISANYLNILCKNNLKVTALYLIQTRTTLEAKRLLHSSQQSIKEITFELGFNDIAYFSNFFKGQTGVSPRQFREQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLA7</accession>
    <name>D7VLA7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein</fullName>
            <ecNumber evidence="4">2.7.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11776</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.-" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999941.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11776"/>
    <dbReference type="EnsemblBacteria" id="EFK58380">
        <property type="protein sequence ID" value="EFK58380"/>
        <property type="gene ID" value="HMPREF0766_11776"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039822_0_0_10"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="199"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="411" mass="47060" checksum="04AF86B894ABEF6C" modified="2010-10-05" version="1">MNPYQYNKQRWKFLLLIFAAIIAGASLFYTNNLVKNLSASERTKAQVWAMSTKSIITMPDVDDEFITFIYAVRDSLALPAIITDQKDNIIFWRDLDSTKTNIRHSEQDSVAANSPVYDPGYFQKELKEMKRSHPPITINLDNGDQWQVFYKDSNELIQLRIFPYVQLSVIAIFLIIAYTVFNSIKKSEQNLVWVGMAKEAAHQLGTPISSLMGWLELVRMRFDAEDDNILNEMERDVKRLEIVADRFSKIGSIPSLSNYNVYTIVNDFINYFRVRTSDKITFTLTGDTHIEAKLNAPLFDWILENLLKNAVNAIESEGLVSVNISENIAKEEIFIDISDTGKGIPKSNFETVFQPGFTTRKRGWGLGLSLTKRMVDYHKGQIFVKESEIGKGTTFRIVLKSNLRYEPTQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLB6</accession>
    <name>D7VLB6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR substrate binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999969.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11785"/>
    <dbReference type="EnsemblBacteria" id="EFK58389">
        <property type="protein sequence ID" value="EFK58389"/>
        <property type="gene ID" value="HMPREF0766_11785"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_10"/>
    <dbReference type="OrthoDB" id="1439189at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="295" mass="33997" checksum="3F75124E9DECD1A5" modified="2010-10-05" version="1">MISKTNQIELRQLRYFRALAEELHYHKAADKLHISQSALSQQIKLLEQQLGVSLFDRLNKKISLSDPGELFYAEAIHILQQVERSMERLDQFHTGSAGTLKIGFVASAMSSFLPEAIKKFHTAYPAIHLRFEEMNNFEQLPALENGDIDIGFMRSNQVRDQMHILRVFEETFTLILPRNHRFGNYHFKDLSILKDEDFILFPNAKSEFYFQQIINLCSDSGFYPRITHQAIHGPTIFSLVGCGMGISIIPTSLAQLHTEDVIAIELKSIPQRTQIFAVWDKSNQNPQIQRFMKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLC2</accession>
    <name>D7VLC2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="8">HTPA reductase</shortName>
            <ecNumber evidence="8">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">dapB</name>
        <name evidence="11" type="ORF">HMPREF0766_11791</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999988.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11791"/>
    <dbReference type="EnsemblBacteria" id="EFK58395">
        <property type="protein sequence ID" value="EFK58395"/>
        <property type="gene ID" value="HMPREF0766_11791"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0289">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047479_1_0_10"/>
    <dbReference type="OrthoDB" id="803114at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="10">
        <location>
            <begin position="106"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="8">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="75"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="100"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK58395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="247" mass="27658" checksum="C61687F2C1E09388" modified="2010-10-05" version="1">MKIVLLGYGKMGQLIEKFAQKRGHEVILVVDQHNRETLTAQDIQDADVAIDFSVPSGALENISLCFEASVPLVVGTTGWYDHLDEVKDICLETDQSLLYGSNFSIGVNIFFHINKMLAKAIQPYHQYDVQVEEIHHVHKLDAPSGTAITIAEGILNNSDIKQQWVNELVDDGDGIIPKPNELLIESLRIEEVPGTHTVLYSSEVDQIEFKHIAHNREGFALGAVIAAEWLQGKKGFYQVTEMFDFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLC3</accession>
    <name>D7VLC3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF5683 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11792</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999991.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11792"/>
    <dbReference type="EnsemblBacteria" id="EFK58396">
        <property type="protein sequence ID" value="EFK58396"/>
        <property type="gene ID" value="HMPREF0766_11792"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZCD0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060256_1_0_10"/>
    <dbReference type="OrthoDB" id="1271497at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043738">
        <property type="entry name" value="DUF5683"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18935">
        <property type="entry name" value="DUF5683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107649" description="DUF5683 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5683" evidence="3">
        <location>
            <begin position="85"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="246" mass="28279" checksum="14B3FAE12DCA47A6" modified="2010-10-05" version="1">MMIKYLFTLFVLISTTVACFAQKADTVKTIPAKNTKPEIEKVVTQDTIKKEESRKERRKREKAEKEAKEKSEEVFKDSARLAIEHKSKVAWKRSLILPGWGQHYNGGLWWIKVPVIYGGFVSTGLIIEFNQRYYSQVLKELDFRISTGDTERKDPELRGMSTTGLIQAKDNFRRNRDLAILGTLGWYGLNIVEAYVDSMLKNRWNIGDAKNVNIRFSPTIISNNSYAFQSGPIRPSVGLKMTMQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLI0</accession>
    <name>D7VLI0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000145.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11850"/>
    <dbReference type="EnsemblBacteria" id="EFK58453">
        <property type="protein sequence ID" value="EFK58453"/>
        <property type="gene ID" value="HMPREF0766_11850"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z90P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042640_0_0_10"/>
    <dbReference type="OrthoDB" id="1496175at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025366">
        <property type="entry name" value="DUF4270"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14092">
        <property type="entry name" value="DUF4270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="453" mass="49615" checksum="4D4E4392199BD459" modified="2010-10-05" version="1">MSRFFKRRNIRYILPILFIAVVTSCNKDISISLDGSDNNLGLSVTDSFTVNVSTFQMDNLPTAATGTILVGKANSAKTGSISSSSYFRLGLGNVSATIPDGATFDSLTLVIKPNQARYYYGDTTVNQKISVHEVTENIILKDITTGIDNNLTPAFVTGPTLFGKQQFNYNSTPLGELTFSPRIKSLDTLSVRLDQNLGNTLFNLFKNNDIKVSSNANFQEFFKGMVIVPAASNTVVLGFNDTLAVKVNYSYIGSDGFKTQAAKTFTIDSKSYQHNNITFDRTGTPYASLNYTNKELKSSETNQEVFVQGGTGVVANIKIPSLREFILDEKISINKAELIIETPNSNTGMYPVPPSVMLMVANINGIPVTAVNFPFTTTIQQVSFSKGNDTGANGKYVFDLIAYLKNINTVNYYDTSLFLTVASPSLFSTANTLEIAKENNKPKVKLNIVYTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLN5</accession>
    <name>D7VLN5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Malonyl CoA-acyl carrier protein transacylase</fullName>
            <ecNumber evidence="3">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fabD</name>
        <name evidence="6" type="ORF">HMPREF0766_11905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fabD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000266.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11905"/>
    <dbReference type="EnsemblBacteria" id="EFK58508">
        <property type="protein sequence ID" value="EFK58508"/>
        <property type="gene ID" value="HMPREF0766_11905"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030558_0_1_10"/>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004410">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00128">
        <property type="entry name" value="fabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="5">
        <location>
            <begin position="6"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000446-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="294" mass="31129" checksum="23BE609F4DAADBA5" modified="2010-10-05" version="1">MKTAYVFPGQGAQFVGMGQDLYNLNDETKALFEQANDILGFRITDIMFNGTDEELKQTKVTQPAIFLHSVILAKALGENFKPDMVAGHSLGEFSALVAAGALTFEDGLQLVAKRANAMQKATEIEPSAMAAILGLEDAIVEETCAKVEETVVAANFNCPGQVVISGTVAGVDKACELLLAAGAKRALKLNVGGAFHSPLMEPARVELQAAIEAVDIKSPVCPIYQNVDAKPQTDPAVIKENLIAQLTGAVRWTQTVQHILSDGAEAFVEVGPGNVLQGLVKKVDRQIPTSAATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLR4</accession>
    <name>D7VLR4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NOL1/NOP2/sun family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yebU</name>
        <name evidence="6" type="ORF">HMPREF0766_11934</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000323.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11934"/>
    <dbReference type="EnsemblBacteria" id="EFK58537">
        <property type="protein sequence ID" value="EFK58537"/>
        <property type="gene ID" value="HMPREF0766_11934"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0144">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_6_0_10"/>
    <dbReference type="OrthoDB" id="1064993at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031341">
        <property type="entry name" value="Methyltr_RsmF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027391">
        <property type="entry name" value="Nol1_Nop2_Fmu_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17125">
        <property type="entry name" value="Methyltr_RsmF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13636">
        <property type="entry name" value="Methyltranf_PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="5">
        <location>
            <begin position="11"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="111"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="453" mass="51441" checksum="D136D73F790097CD" modified="2010-10-05" version="1">MSNILPNSLIRKLGANPLFDEQAFIDIHENGERQSSIRINEKKITTAPFAHAEPIPWCDRGFYLVERPSFTLDPLYHAGCYYSQDASSMFISHIIQHLKLDGEPLKALDLCAAPGGKTTLLNSYLHPQSLLVANEIIKTRVPILMENMVRWGNSNVVITNNDPSAFRRLPGYFDLVLIDAPCSGSGMFRKDSGAIDEWSEANVKLCSERQQRILAEAMGCLKTDGILLYSTCSYSQEENEDIADWLVKEYGLKSIQIPVREEWGIEETKSDISTCFGYRFYPHKVKGEGFFITAFVKTAFQETFNRKKIKPEKSDVPNGIIEHWLNNASTHTAFLHHENVHIFPKDYETDLKILQNVLYLKNAGTNIGKLAGKELIPAHGLALSTAIKANFPTLELTLEEAQNYLRKENIDPEHNLKNGWTLVTYKNVKLGWIKILANRINNYYPKESRIAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLV2</accession>
    <name>D7VLV2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RHS repeat-associated core domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12206"/>
    <dbReference type="EnsemblBacteria" id="EFK58214">
        <property type="protein sequence ID" value="EFK58214"/>
        <property type="gene ID" value="HMPREF0766_12206"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_359253_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="779" mass="86517" checksum="93E48A413C19375C" modified="2010-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLX7</accession>
    <name>D7VLX7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK57982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001086.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11974"/>
    <dbReference type="EnsemblBacteria" id="EFK57982">
        <property type="protein sequence ID" value="EFK57982"/>
        <property type="gene ID" value="HMPREF0766_11974"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031960_9_2_10"/>
    <dbReference type="OrthoDB" id="991474at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107090" description="Beta-lactamase2 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase2" evidence="2">
        <location>
            <begin position="50"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="300" mass="34032" checksum="5AFEC9C82140FC3D" modified="2010-10-05" version="1">MKNLSLFLTLFLLSVASSAFAQKTDQKLEKKLKELTRDFHGDIGIYVRHLRTNKEVMINADSIFPTASIIKVPILAGVFNKIGKGELKYNDKFVYRQSRVYGGSGLMQFFKDSIETDLSTMAALMIGYSDNVTSIWCQELAEGTKINELMDELGLPNTRVNSRTAGREAIWKKYGWGHTTPREMATLLTLIRAGKVISPDLSDKMYRILGNVFYNERSLSQIPSYIKTASKSGSLEDVRTEVVLVNAPSGDYVFSVFTKNNKDRSWEKSNEAEVLTRSISSLLWNYFEPKHPFPKQRLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM66</accession>
    <name>D7VM66_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001343.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12063"/>
    <dbReference type="EnsemblBacteria" id="EFK58071">
        <property type="protein sequence ID" value="EFK58071"/>
        <property type="gene ID" value="HMPREF0766_12063"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1467669_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107327" evidence="1">
        <location>
            <begin position="23"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="190" mass="21230" checksum="BBDA992CBA004C24" modified="2010-10-05" version="1">MRKSKKTMIGIILIMASFYLSSCKNSSIEVPVKSKNEFKMNYTAAKTSNELIALRENKNANVIRTGLDLESVISSQSTALSKLSNEQLEKFMKGIVFKENVGVVGFNYQILNNSLAADDFAEVMALFGLDVKHGFWGFSSDKNIAEKLSINEEIRGGSARSLMFEDYKGYRCESPHNCRMNSDYICLTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMJ6</accession>
    <name>D7VMJ6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gldA</name>
        <name evidence="5" type="ORF">HMPREF0766_12216</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992625.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12216"/>
    <dbReference type="EnsemblBacteria" id="EFK57143">
        <property type="protein sequence ID" value="EFK57143"/>
        <property type="gene ID" value="HMPREF0766_12216"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_10"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="235" mass="26308" checksum="0E89BDE0F7E2D40A" modified="2010-10-05" version="1">MSIVLRQITKTYHQQKALDEISFDVSSNTIVGFLGPNGAGKSTTMKIMTGLIPADSGTVVINGLNLKNSHREIKKLIGYLPENNPLYGEMYVREILAFEAGVHQIPNKSQRIEEVMHLTGLESEQHKKVQQLSKGYRQRVGLAMAIIHDPQVLILDEPTTGLDPNQILEIRSLIKTLGKEKTVIFSTHIMQEVEAICDAVIILKKGKVMENFPLKESDIKYPGLTMEDIFVQITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMK6</accession>
    <name>D7VMK6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Cysteine synthase</fullName>
            <ecNumber evidence="5 11">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cysM</name>
        <name evidence="13" type="ORF">HMPREF0766_12226</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5 11"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992647.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12226"/>
    <dbReference type="EnsemblBacteria" id="EFK57153">
        <property type="protein sequence ID" value="EFK57153"/>
        <property type="gene ID" value="HMPREF0766_12226"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_10"/>
    <dbReference type="OrthoDB" id="1033353at2"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005858">
        <property type="entry name" value="CysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314:SF100">
        <property type="entry name" value="PTHR10314:SF100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01138">
        <property type="entry name" value="cysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 9 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="6"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="9">
        <location>
            <begin position="171"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFK57153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="290" mass="31650" checksum="1747E37979401DE2" modified="2010-10-05" version="1">MGNIIDTIGNTPLVEITKFHNNPKVKIYAKMEGNNPAGSVKDRAALNMIRSALKRGEITGESKLIEATSGNTGIALAMIAGMYGLSLELVMPSTSTRERTLTMEAFGAKVTLLESMEVCRDYAEDKAASGEYFILNQFANPDNYKAHIKTTGPEIWRDTEGKITHFVSAMGTTGTIMGNSMFLKEKNADIQIVGCQPTEESSIPGIRRWPQEYLPKIFDASRVDRVIDISQAESTQMARELVKREGIFAGMSTGGAFAAALKVANELEEGVIVFIACDRGDRYLSSDLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMP0</accession>
    <name>D7VMP0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_12260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992716.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12260"/>
    <dbReference type="EnsemblBacteria" id="EFK57187">
        <property type="protein sequence ID" value="EFK57187"/>
        <property type="gene ID" value="HMPREF0766_12260"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_0_10"/>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="336" mass="38130" checksum="97EFF89CE73EACA7" modified="2010-10-05" version="1">MKFENYTIKDIAQALNLSTSTVSRALRDSYEISPETKKIVLEYAEKVNYRANPIARSLKEKRSYSIGIVLSEIANNFFSQVINGVESVAYQKNYNVMISQTHESAEREKLNVEYLSSRSVDGLLIALASETEDISYLRKLYERGFPIVFFDRVPEDFDTFKVIVNNYKGAFAATEQLILSGKRKIAHLNNAKNLSITRERLKGYQDALKKYHIPFNEDLVKHCLYGGMNLNELENVVDELLEQNFDAIFISGDRLSTGFLMALKSKNPELANKIAISGFTNSNVVSLFSPTMNVVRQPAVEMGKIATELLIKMIESNYPIEEFETITLQTELIKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMT1</accession>
    <name>D7VMT1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">rplK</name>
        <name evidence="11" type="ORF">HMPREF0766_12301</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6 8">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992779.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12301"/>
    <dbReference type="EnsemblBacteria" id="EFK57228">
        <property type="protein sequence ID" value="EFK57228"/>
        <property type="gene ID" value="HMPREF0766_12301"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074237_2_1_10"/>
    <dbReference type="OrthoDB" id="1702697at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="10">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="9">
        <location>
            <begin position="71"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK57228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="147" mass="15541" checksum="0A723C9A776E8A2E" modified="2010-10-05" version="1">MAKEVSALVKLQVKGGAANPSPPVGPALGAKGVNIMDFCKQFNARTQDKPGKVLPVVITVYSDKSFDFIIKTPPVAIQLKEATGLKSGSGEPNRKKVASVTWDQVKTIAEDKLVDLNAFTVEAAMRMVAGTARSMGITVSGNAPWNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMU4</accession>
    <name>D7VMU4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane lipoprotein carrier protein LolA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992806.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12314"/>
    <dbReference type="EnsemblBacteria" id="EFK57241">
        <property type="protein sequence ID" value="EFK57241"/>
        <property type="gene ID" value="HMPREF0766_12314"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105362_0_0_10"/>
    <dbReference type="OrthoDB" id="1933827at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16325">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004564">
        <property type="entry name" value="OM_lipoprot_carrier_LolA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35869">
        <property type="entry name" value="PTHR35869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03548">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107447" evidence="1">
        <location>
            <begin position="24"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="218" mass="24399" checksum="B4E23A15F02941EF" modified="2010-10-05" version="1">MKTTLWSFVVAAFMLFISNPVSAQQEAFAKKLLNQVSAKYDGYKTIKASFSFSAKQANGGTYTDAGTLYLDKKANKYLIEMKSQDLISDGKSSWTILKEEDEVQINDADQSNDNINPSNIFSFYKTGFKYVSADDEKVGATTLNVIELSPIDTKKNYFKIKLRINKASKLIYDATIFDKSGSRYTYTIKSLNGNASIAASTFTFNKSKYPGMEIVDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMX4</accession>
    <name>D7VMX4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF695 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992854.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12344"/>
    <dbReference type="EnsemblBacteria" id="EFK57271">
        <property type="protein sequence ID" value="EFK57271"/>
        <property type="gene ID" value="HMPREF0766_12344"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8C2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_754052_0_0_10"/>
    <dbReference type="OrthoDB" id="743650at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016097">
        <property type="entry name" value="DUF695"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05117">
        <property type="entry name" value="DUF695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF695" evidence="1">
        <location>
            <begin position="239"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="364" mass="42501" checksum="4803B795BBEE6D95" modified="2010-10-05" version="1">MSFLKNIFGNKKETVKTYEDFWIWFQANEQTFHNIIKNGKNPEKDFFDKLSQKLSEIKDGFYFLVGMLNDNTAELVFTPDGIIQNIVFVEELVNAAPILPHWKFTALKPSVDIENLGIKMGNYEFNSNNLSFYAIDHAGYPDEVDIVIIHSNYNEEDKSTIINGTFIFLDNYLGELNAVTTIDNAIVISREQAEKEPIPITKLKDYLIWREKEFVEKYSGIRYNTENDSYASLEAELNNGLPLIAIVNSTLLQWNSKASHPWILTIEINYKDSNNNGMPDKNTYELLNELEDQVMLKLKDIDGYLNIGRQTADNSREIYFACHDFRKPSKVLHELSKKYSNKLDIKYNIYKDKYWQSFERFRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN02</accession>
    <name>D7VN02_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD hydrolase, TIGR02254 family</fullName>
            <ecNumber evidence="1">3.1.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yjjG</name>
        <name evidence="1" type="ORF">HMPREF0766_12372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992896.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12372"/>
    <dbReference type="EnsemblBacteria" id="EFK57299">
        <property type="protein sequence ID" value="EFK57299"/>
        <property type="gene ID" value="HMPREF0766_12372"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_1_10"/>
    <dbReference type="OrthoDB" id="1204073at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011951">
        <property type="entry name" value="HAD-SF_hydro_IA_YjjG/PynA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02254">
        <property type="entry name" value="YjjG/YfnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="233" mass="27166" checksum="6A7DB3E7FB97EB3D" modified="2010-10-05" version="1">MFHHKKDIFFDLDHTIWDFDKNAEETLDELFFKYDFDKLFNHSSADLFISTYTSNNHRLWNLYHHGKIDKPTLRKARFENTFTDLGVDPSLFPKDFEEEYLFICPQKTNLFPNAHETLAYLKERYNLHLISNGFKEACEVKLGKSDLEQYFQHIFISELVGVNKPDPLIFHHAMQTAGTSATHAVMIGDNLDADVRGARNVGMDAIYFNPNQTQLPKDVSHSITDLSELKHMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN51</accession>
    <name>D7VN51_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992960.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12421"/>
    <dbReference type="EnsemblBacteria" id="EFK57348">
        <property type="protein sequence ID" value="EFK57348"/>
        <property type="gene ID" value="HMPREF0766_12421"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2221548_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="106" mass="11638" checksum="7C7A64E3F1340A23" modified="2010-10-05" version="1">MKKPIIIPVTLSNGENVKIPLLYTITNDDNNPNIRFIDCQVDLPDEEIPEWLSPTTFTIRQVCLPGEAGGLGVTNTEVSHIRCKNTDTAKFIGNTFLGIKGIEGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN61</accession>
    <name>D7VN61_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992974.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12431"/>
    <dbReference type="EnsemblBacteria" id="EFK57358">
        <property type="protein sequence ID" value="EFK57358"/>
        <property type="gene ID" value="HMPREF0766_12431"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1785660_0_0_10"/>
    <dbReference type="OrthoDB" id="2051472at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="145" mass="16290" checksum="B248DA8D624FB27C" modified="2010-10-05" version="1">MIAKVLKNSIEGMKDVKSVLIVAGIEDLITGEIRLFQRKLGSTKEDCVINTLIWDAEQIQGGVLNINFHVPNLPGSSAENPTVVDNTQPDIQRMEYLGRIASSKLDGYIGPNFSLKLRDPGHIENFGKQWLYNIQVEYTFLRTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN87</accession>
    <name>D7VN87_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993001.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12457"/>
    <dbReference type="EnsemblBacteria" id="EFK57384">
        <property type="protein sequence ID" value="EFK57384"/>
        <property type="gene ID" value="HMPREF0766_12457"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2829030_0_0_10"/>
    <dbReference type="OrthoDB" id="166930at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="66" mass="7352" checksum="3A2406E03C2D5B4C" modified="2010-10-05" version="1">MFNKDFFPTPKEVIHQMLAPYELTGKTVLEPSSGKGDIIDEMVELGANVICCELNDDLALPESIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNA8</accession>
    <name>D7VNA8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter, ATP-binding protein</fullName>
            <ecNumber evidence="11">3.6.3.43</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">lktB</name>
        <name evidence="11" type="ORF">HMPREF0766_12478</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.43" evidence="11"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993033.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12478"/>
    <dbReference type="MEROPS" id="C39.001"/>
    <dbReference type="EnsemblBacteria" id="EFK57405">
        <property type="protein sequence ID" value="EFK57405"/>
        <property type="gene ID" value="HMPREF0766_12478"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_95_3_10"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005074">
        <property type="entry name" value="Peptidase_C39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03412">
        <property type="entry name" value="Peptidase_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50990">
        <property type="entry name" value="PEPTIDASE_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C39" evidence="10">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="178"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="492"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="526"/>
            <end position="533"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK57405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="733" mass="83355" checksum="79721825E313F3C6" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNJ2</accession>
    <name>D7VNJ2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage/plasmid-related protein TIGR03299</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993143.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12562"/>
    <dbReference type="EnsemblBacteria" id="EFK57489">
        <property type="protein sequence ID" value="EFK57489"/>
        <property type="gene ID" value="HMPREF0766_12562"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7QU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058825_1_0_10"/>
    <dbReference type="OrthoDB" id="1540547at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026325">
        <property type="entry name" value="DUF932"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017686">
        <property type="entry name" value="Phg/plasmid-like_prot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06067">
        <property type="entry name" value="DUF932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03299">
        <property type="entry name" value="LGT_TIGR03299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="357" mass="39241" checksum="22EC1397B6B7B7C7" modified="2010-10-05" version="1">MAHNINYNEKTGRYSFFSVQQKAWHGLGQIVEQYPTSEEAIRHAGLDYEVVKSPLFTKGSGITETADGIEIGSNELEVPNCFANIRTDNNAVLGVVGKDYHIVQNREAFSFFDAIVGGGEGILYETAGALGKGERIFITAKLPDYIRVGNGDDVTEKYIFLTTSHDGSGSITAAFTPIRIVCQNTLNASLRNMTNVVRIKHTSGAKQRIENAHRIMGLANTLSDQLQGIFNDWTTIRATDQEVRKLIQLALCPNKETLELIKKGAEDEISTMFKNAVNDAFAYAMTSDTQQMDTTKGTLFGAYNAVTGYFQNVRNYRDDEAKLQSIVLGGTAQMKGQKAFDLCTAFATDGAEILNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNP5</accession>
    <name>D7VNP5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3347 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993215.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12615"/>
    <dbReference type="EnsemblBacteria" id="EFK57542">
        <property type="protein sequence ID" value="EFK57542"/>
        <property type="gene ID" value="HMPREF0766_12615"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101306_0_0_10"/>
    <dbReference type="OrthoDB" id="1905459at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021782">
        <property type="entry name" value="DUF3347"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11827">
        <property type="entry name" value="DUF3347"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107084" description="DUF3347 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3347" evidence="3">
        <location>
            <begin position="56"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="192" mass="21323" checksum="983A463D6F5434CA" modified="2010-10-05" version="1">MTMKHLFVGLLASSVLTLAACNGASEKKSESDVHTETTVSNESNAASDQGTFSELFSHYQHLTFALSSDNDKEAANAAKGMLEALPKINTEGFSAEQKSTFDDIAADIQEHSEHIGDNIGNIAHQREHLVILSKDFYDITKEFGTEKPMYKIFCSMYDDNKGAYWLSDSKEVKNPYYGEDMLTCGEVQEELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNR4</accession>
    <name>D7VNR4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12634"/>
    <dbReference type="EnsemblBacteria" id="EFK57561">
        <property type="protein sequence ID" value="EFK57561"/>
        <property type="gene ID" value="HMPREF0766_12634"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_3_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="192" mass="20571" checksum="FCAC6D801289A1FA" modified="2010-10-05" version="1">MGEKIKLPEDYHIEYGGQFEAEAEASQTLIATSLLSILIIFLILFREFKTVKLAAIILINLSLALIGGVFSIYFTSGILSIPAIIGFITLFGVATRNGILLVSHYNTLCDEGLDLYDTVIQGSKNRLSPILMTALTAGLALIPLAIAGDLPGNEIQSPMAKVILGGLLTSTLLNIFIVPAVYYLSNKKAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNU5</accession>
    <name>D7VNU5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993296.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12665"/>
    <dbReference type="EnsemblBacteria" id="EFK57592">
        <property type="protein sequence ID" value="EFK57592"/>
        <property type="gene ID" value="HMPREF0766_12665"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032TG4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133781_2_2_10"/>
    <dbReference type="OrthoDB" id="2076478at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="41"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="93" mass="11271" checksum="E6F40BDBD2A0C2C9" modified="2010-10-05" version="1">MNIDRMEFIAWMERIMDRFDMLGDNIDDLKKKRNSIDGEELLDNQDLLQMLKISNRSLQRYRSIGKLPYYTISGKLYYKLSDVHQFIRESFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNZ6</accession>
    <name>D7VNZ6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heavy metal efflux pump, CzcA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cusA2</name>
        <name evidence="2" type="ORF">HMPREF0766_12716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993380.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12716"/>
    <dbReference type="EnsemblBacteria" id="EFK57643">
        <property type="protein sequence ID" value="EFK57643"/>
        <property type="gene ID" value="HMPREF0766_12716"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_10"/>
    <dbReference type="OrthoDB" id="91817at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="511"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="601"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="645" mass="71770" checksum="7EAACB1B398B34A9" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP09</accession>
    <name>D7VP09_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_12729</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12729"/>
    <dbReference type="EnsemblBacteria" id="EFK57656">
        <property type="protein sequence ID" value="EFK57656"/>
        <property type="gene ID" value="HMPREF0766_12729"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="129"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="438"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1065" mass="117641" checksum="E10874580CC35339" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP30</accession>
    <name>D7VP30_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12750"/>
    <dbReference type="EnsemblBacteria" id="EFK57677">
        <property type="protein sequence ID" value="EFK57677"/>
        <property type="gene ID" value="HMPREF0766_12750"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2587952_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="80" mass="9217" checksum="AE973B3345140359" modified="2010-10-05" version="1">MVEIRLNIKSLKMDLNFREMVKNKFRLMLLTFIIFTACSIQGCSGSRDLCSAYDSHKSPRKSKTSMGMHSGKKQKWQNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP43</accession>
    <name>D7VP43_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993457.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12763"/>
    <dbReference type="EnsemblBacteria" id="EFK57690">
        <property type="protein sequence ID" value="EFK57690"/>
        <property type="gene ID" value="HMPREF0766_12763"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_0_1_10"/>
    <dbReference type="OrthoDB" id="1031920at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="191"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="377" mass="44150" checksum="FE20C71858F3517B" modified="2010-10-05" version="1">MEYNKEVIITEKKLSTNKVKRILLVVFAFLLFYLVSFLIDPYGEFWQEYFQRGIFEIIEELVISFIFCFLISESSIFIHSRLNKYAPWTKNKIKRLVLELSLNFFVVLILIVLNSVCYYLIYDDPAYSQSEPSIEEIRNLLQFIIVSMIISFMIISINTGSYLINNWVNTETQVANHKLRTAEWKQASVEAELNALKLQLNPHFIFNNLSVLSELILEDQQLGYAYSENFSKVYRFLLVNSKKNMILLEEELKFLNSYIFLIKHRIGEGVHFEIDVQEESKNMYIPPLTLQLLIENALKHNKTDRKNPLRITIRTSTQHILTVENTLSLIEKPEGYSTGIGLTNIISRFNLLSKQPPEIVTSTDSFKVIIHLMEYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP80</accession>
    <name>D7VP80_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993525.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57727">
        <property type="protein sequence ID" value="EFK57727"/>
        <property type="gene ID" value="HMPREF0766_12800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033III">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_192311_0_0_10"/>
    <dbReference type="OrthoDB" id="2049335at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="59" mass="6726" checksum="2C3E70C6327602B9" modified="2010-10-05" version="1">MGVTRLKRKDRRNKTVSRVEVQFLKLGRNIELGSKSQMPKDSQITKNNAILDQLASKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPJ2</accession>
    <name>D7VPJ2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993754.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12912"/>
    <dbReference type="EnsemblBacteria" id="EFK57839">
        <property type="protein sequence ID" value="EFK57839"/>
        <property type="gene ID" value="HMPREF0766_12912"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_10_4_10"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="326"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="434" mass="48277" checksum="6802288956E35815" modified="2010-10-05" version="1">MKIKLLGLGALLVFAHLDGFSQEKRKMTLAEIIQLASTQSTEAHLSDTKIESRRLEVQSAKNSQLPEAQLSGQYMLMTTPDINFHIPLGGSGGAPDIKANQLMLGRATINMPIYTGGKITESIHASENALKAEQWSALATKDQLSKRALSLYLNLYKAQQTNLLIEENIKRSRQRVEDFKAMETNGVIARNDLLKAELQLSNYLVAQQEAQKNVKVMNYQLANFLKLDEQTEFAQIDLEAVNVPNLHASMETAVANRSDLKAAEAQHDVALNQVKIAKAANYPTLFATGGYTAMDVKNVITVKNAMNVGVGVSYDISSLYKNKKNVNVARNKVREVEDNMSLLNDQIKVQVQQANENYELAKAQDRVYVQAVDQANENFRIVKDKYDNGVADTDDLLEADVQQLQSRINLAIGKANTVEKYYDLLLTNGEINQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPN3</accession>
    <name>D7VPN3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroneopterin aldolase</fullName>
            <ecNumber evidence="2">4.1.2.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">folB</name>
        <name evidence="2" type="ORF">HMPREF0766_12953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993814.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12953"/>
    <dbReference type="EnsemblBacteria" id="EFK57880">
        <property type="protein sequence ID" value="EFK57880"/>
        <property type="gene ID" value="HMPREF0766_12953"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112632_1_2_10"/>
    <dbReference type="OrthoDB" id="1858654at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006760">
        <property type="term" value="P:folic acid-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FolB" evidence="1">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="121" mass="13760" checksum="2D91589979257CD0" modified="2010-10-05" version="1">MATRIQTIAINDARFYAPVGYYAEEIVTGNEFLVDIEVSYPYKVHSQDELTNTLNYEQLYAIAADVMKQKRKLIESAVEEILETIVNQFDFAEQVNVSITKINPLFGGDRANSRIALSYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPW5</accession>
    <name>D7VPW5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14325"/>
    <dbReference type="EnsemblBacteria" id="EFK57122">
        <property type="protein sequence ID" value="EFK57122"/>
        <property type="gene ID" value="HMPREF0766_14325"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3317198_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="39" mass="4130" checksum="A519822D6977A028" modified="2010-10-05" version="1">MKVIITGATGMVGEGVLLECLNNTAVVEVLIIGRKNYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPZ3</accession>
    <name>D7VPZ3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_13047</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993960.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13047"/>
    <dbReference type="EnsemblBacteria" id="EFK55844">
        <property type="protein sequence ID" value="EFK55844"/>
        <property type="gene ID" value="HMPREF0766_13047"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_0_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="141"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="460"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK55844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1053" mass="116112" checksum="7179AFC6A151F79C" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPZ7</accession>
    <name>D7VPZ7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpmI</name>
        <name evidence="6" type="ORF">HMPREF0766_13051</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993964.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13051"/>
    <dbReference type="EnsemblBacteria" id="EFK55848">
        <property type="protein sequence ID" value="EFK55848"/>
        <property type="gene ID" value="HMPREF0766_13051"/>
    </dbReference>
    <dbReference type="GeneID" id="66688127"/>
    <dbReference type="eggNOG" id="COG0291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169643_4_3_10"/>
    <dbReference type="OrthoDB" id="2046660at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK55848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="66" mass="7383" checksum="7AC7E8A9A83EDF7D" modified="2010-10-05" version="1">MPKVKTNSSAKKRFKLTGTGKIARKNAFKSHILTKKSTKRKRNLTQTSYVSDGDMGNVKRMLAIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPZ8</accession>
    <name>D7VPZ8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rplT</name>
        <name evidence="7" type="ORF">HMPREF0766_13052</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993965.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13052"/>
    <dbReference type="EnsemblBacteria" id="EFK55849">
        <property type="protein sequence ID" value="EFK55849"/>
        <property type="gene ID" value="HMPREF0766_13052"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123265_0_1_10"/>
    <dbReference type="OrthoDB" id="1932144at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK55849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="114" mass="12990" checksum="E7E214A4A917DEF7" modified="2010-10-05" version="1">MPRSVNAVASRRRRKKILKLAKGYYGSRSKVYTIAKNTVEKGLQYAYRDRKTKKREFRALWIQRINAGSRQHGISYSQLIGKLNAKNIGLNRKVLADLALNNPDAFKAVVDAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ15</accession>
    <name>D7VQ15_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993988.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13069"/>
    <dbReference type="EnsemblBacteria" id="EFK55866">
        <property type="protein sequence ID" value="EFK55866"/>
        <property type="gene ID" value="HMPREF0766_13069"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008878_4_0_10"/>
    <dbReference type="OrthoDB" id="365211at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="1">
        <location>
            <begin position="63"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="2">
        <location>
            <begin position="425"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK55866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="561" mass="62746" checksum="3321BB83FF6A8F6C" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ38</accession>
    <name>D7VQ38_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">merR</name>
        <name evidence="2" type="ORF">HMPREF0766_13092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994024.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13092"/>
    <dbReference type="EnsemblBacteria" id="EFK55889">
        <property type="protein sequence ID" value="EFK55889"/>
        <property type="gene ID" value="HMPREF0766_13092"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_20_1_10"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="47"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="104" mass="12043" checksum="EA775F5DA125FA6F" modified="2010-10-05" version="1">MKTDVEKKHKNIKTFAQHLDKRYGVTGTKERIDFEIKAKSFAIGEMIKQERKLAKMTQEQLAEKIGAKKSFISRIENGHSDIQLSTLYKLIEFGLGRKINFTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ80</accession>
    <name>D7VQ80_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13134"/>
    <dbReference type="EnsemblBacteria" id="EFK55931">
        <property type="protein sequence ID" value="EFK55931"/>
        <property type="gene ID" value="HMPREF0766_13134"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3103960_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="51" mass="5969" checksum="49466C07DCB11834" modified="2010-10-05" version="1">MLICFSTKEQVGQNRVERCISDIKKCLFDIKKSIILNKNVDLLFIEYLAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQI2</accession>
    <name>D7VQI2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13236"/>
    <dbReference type="EnsemblBacteria" id="EFK56033">
        <property type="protein sequence ID" value="EFK56033"/>
        <property type="gene ID" value="HMPREF0766_13236"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1915764_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="141" mass="16078" checksum="849C3D7D6EB64F95" modified="2010-10-05" version="1">MIINSYNMQKKIPKYSFLLLTIALSFLSRCSTTVKFGKLAKYNLRYKNDKNIENGKTAISINLFDLNDKNEIEIANVKTLPGLTIDSSNNYKLLLFDSDSIPSNIRIDKPGKIPIPIYPKKGKKNLIIYKIYLGDDIRGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQL9</accession>
    <name>D7VQL9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994383.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13273"/>
    <dbReference type="EnsemblBacteria" id="EFK56070">
        <property type="protein sequence ID" value="EFK56070"/>
        <property type="gene ID" value="HMPREF0766_13273"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030011_2_0_10"/>
    <dbReference type="OrthoDB" id="704008at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="456" mass="50826" checksum="D78F90A8495AF0B7" modified="2010-10-05" version="1">MTLNDTLIAAHHSFTGYFGVAECDITPPLDIYARNWGAAPSDQASGLHRPLLMQCVLFQTEDEISLVMITADLGWWKNEPDERNLRHYILQQTDLQEEQLLFCLSHTHSGPVICTADADKPGGEYIRPYLESLAVQSVELIQQAQHNLIAGTLTWTYGKCDLAKKRDLKIDDSYLIGYNPSDRADDTVLVGCIRDNANQTLATLVNYACHPTTFAHENRLLSPDFVGAMREEVTSKTGGICMFLQGASGDLAPMEQYVSDPAIVDRHGRRLGFAVLSALESLPANNQGLYFKEALVSGAPLALWKTCDLPPHQLLTKKIVEVVVDYKKLPTVAEITAEYEACTDRVLKDRLWRKLNTRKSIGDQKQAVIRLWVWQLGNSVIVGQANEAYSIIQEQIRAAFPDKSVAFINIANGYVGYLPPAELYGLDIYAVWQTPYAQGSLEILINKTIQAIQELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQP6</accession>
    <name>D7VQP6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase, C-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0766_13300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994415.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13300"/>
    <dbReference type="EnsemblBacteria" id="EFK56097">
        <property type="protein sequence ID" value="EFK56097"/>
        <property type="gene ID" value="HMPREF0766_13300"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_528673_0_0_10"/>
    <dbReference type="OrthoDB" id="514740at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="26"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="120"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="231"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK56097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="496" mass="56210" checksum="77E0F2EC19466390" modified="2010-10-05" version="1">MKEGFEIFLRKFEDRIHELFHHESDINELSINRGLPQDVWDKIMELKPLSVAIPENFGGRGAKVSECLSILAAASYESLPLSLTFGINIALFLEPLARYGHSDVQQPIFDRFLHHKAMGGLMITEPDFGSDALNMRTQYEESEAGYKLKGQKHWQGLTGMADFWIIAARKDAGKGDLARDVEFFVTDNSRPEQQIQVEHYFNNLGLYMIPYGMNTIDLEVPANQKLLQKSTGIKMMLDILHRSRLQFPGMGMGFIKRMLDEALSHCTNRKVGGQQLLALDSVQYQISRIQSSYSLCSGMCARSSSMSGIDQDLATAGLEANSMKALVTDLMQEAAQICVQLSGSSGYKIDHVAGRGIVDSRPFQIFEGSNEMLYTQIAEMVIKQMKKSRETNFGQYLQGFERCDRVAVLFKPVLDFQITESLVQRQMVVLGKIIARLVCLQYVGDMTDKGFRTDLYDNCVKHIEMDIKKLLSDFLNYNDAKPIVEYEEQSNWIDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQQ1</accession>
    <name>D7VQQ1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994421.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13305"/>
    <dbReference type="EnsemblBacteria" id="EFK56102">
        <property type="protein sequence ID" value="EFK56102"/>
        <property type="gene ID" value="HMPREF0766_13305"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009942_2_1_10"/>
    <dbReference type="OrthoDB" id="751534at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="76"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="577" mass="63865" checksum="532B389996ED0A7E" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQX8</accession>
    <name>D7VQX8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994520.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13382"/>
    <dbReference type="EnsemblBacteria" id="EFK56179">
        <property type="protein sequence ID" value="EFK56179"/>
        <property type="gene ID" value="HMPREF0766_13382"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1554306_0_0_10"/>
    <dbReference type="OrthoDB" id="1854395at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="172" mass="19363" checksum="179B526B2FF10EA4" modified="2010-10-05" version="1">MLSAREGKTMSKFILCIIGSFLFSTGCRDIGKNTVSNETKVVEEPTKVTKTYFLNHDIRNINYEIFVNDSLLAQSHNGDGIPAPYELTAYLKDSGKQQIHVKVIPDGQINKAITPGIVKEINKNLGIYLLEGKDYGNAKEIKHLSFPEINSDLPHYEYTWEFEVGDVPNIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR09</accession>
    <name>D7VR09_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TonB-dependent siderophore receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0766_13413</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994567.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13413"/>
    <dbReference type="EnsemblBacteria" id="EFK56210">
        <property type="protein sequence ID" value="EFK56210"/>
        <property type="gene ID" value="HMPREF0766_13413"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_9_4_10"/>
    <dbReference type="OrthoDB" id="169533at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107257" evidence="7">
        <location>
            <begin position="21"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="9">
        <location>
            <begin position="132"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="8">
        <location>
            <begin position="330"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK56210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="794" mass="88045" checksum="7329F71E48661063" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRJ6</accession>
    <name>D7VRJ6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TonB_dep_Rec domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994800.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13600"/>
    <dbReference type="EnsemblBacteria" id="EFK56397">
        <property type="protein sequence ID" value="EFK56397"/>
        <property type="gene ID" value="HMPREF0766_13600"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_1_0_10"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107479" description="TonB_dep_Rec domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="2">
        <location>
            <begin position="489"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1102" mass="120556" checksum="4BC5846C0C49474A" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRL8</accession>
    <name>D7VRL8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulator, AraC family</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ada</name>
        <name evidence="7" type="ORF">HMPREF0766_13622</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994848.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13622"/>
    <dbReference type="EnsemblBacteria" id="EFK56419">
        <property type="protein sequence ID" value="EFK56419"/>
        <property type="gene ID" value="HMPREF0766_13622"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_0_10"/>
    <dbReference type="OrthoDB" id="1327994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="6">
        <location>
            <begin position="16"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="287" mass="32078" checksum="13626D9B822002C5" modified="2010-10-05" version="1">MIIMDTQQEVDYQRIANAITYIRDHFKAQPSVEEIAAHIHVSPAHFQRMFASWAGTSPKKFLQYISVEHAKKLLREDSRISLFDATYDTGLSSTSRLHDLFIKIEGMTPAEYKNGGKNLLIRYSFTDSPFGKLIIGSTEKGICFMGFAEHEEDGTEQLRQRFPNASLITGTDSMQEHAALIFQHDWSRLSEIKLHLKGTPFQLKVWETLLKIPMGQLATYGQLAKEIGNTKASRAVGTAIGSNPVAFLIPCHRVIQSTGSIGGYMWGPTRKTAIIGWESALQETAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRR7</accession>
    <name>D7VRR7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_hyd_65N_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994973.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13671"/>
    <dbReference type="EnsemblBacteria" id="EFK56468">
        <property type="protein sequence ID" value="EFK56468"/>
        <property type="gene ID" value="HMPREF0766_13671"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014621_0_0_10"/>
    <dbReference type="OrthoDB" id="179460at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hyd_65N_2" evidence="1">
        <location>
            <begin position="30"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="750" mass="85573" checksum="47A5CEB6A7E3DEAB" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRS7</accession>
    <name>D7VRS7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yijO</name>
        <name evidence="2" type="ORF">HMPREF0766_13681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994999.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13681"/>
    <dbReference type="EnsemblBacteria" id="EFK56478">
        <property type="protein sequence ID" value="EFK56478"/>
        <property type="gene ID" value="HMPREF0766_13681"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_2_10"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="183"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="283" mass="33210" checksum="A94589B3F6C2F7D5" modified="2010-10-05" version="1">MVASIPILDQCSLSRTQENTITVEALSSYLSRNKNLVFPHRHSFYQLLLFTQGGGTHAIDFETFEVVPWQIYMMLPGQIHRWDFEGEMDGFIVNFQPDFFHTFLLRPEYLNQFSFFSGLIKDQVFDISPDLQNEVVRLFRELLSTRDLDFAKITLLYLFRTLEKRPLLQDKSESAVYNHTLLRNFISLIESNYRTLRLPKDYAKLLFITPNHLNALVKESIGLSAGELIRNRVLLEAKRLLVIQDYSISEIAYGLNFNDNSYFTKFFKKNEGITPEEFRKKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS04</accession>
    <name>D7VS04_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13758"/>
    <dbReference type="EnsemblBacteria" id="EFK56555">
        <property type="protein sequence ID" value="EFK56555"/>
        <property type="gene ID" value="HMPREF0766_13758"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_34_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="116" mass="13468" checksum="D8531F3EFA9717AB" modified="2010-10-05" version="1">MSPKIKQLKTGHKCLDLSNKMKKTRFTETQIVRALKEGEEGRKTDDICRELEISKATFYNWKSRYGGMEVSDVKRLKELEEENARLKKMFAELSMNHDILKEVITKKGWGSGNKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSC9</accession>
    <name>D7VSC9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13883"/>
    <dbReference type="EnsemblBacteria" id="EFK56680">
        <property type="protein sequence ID" value="EFK56680"/>
        <property type="gene ID" value="HMPREF0766_13883"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033H5E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1915761_0_0_10"/>
    <dbReference type="OrthoDB" id="1993957at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="150" mass="17070" checksum="79F9A4683B6CC6CD" modified="2010-10-05" version="1">MNNGSIKLLQACLLICTVMILTIMQGYWALWEYRTAPSSSCLDCSFFPDLMISSLLPLLAMAVIHLAFVWIKPRLIIKAGTVALTLILCWYLIDTAIFDEREASWSTYTELWSVSLYMCALQIITFGLIAAGVYYKLYSKKTPVKKTYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSU8</accession>
    <name>D7VSU8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995822.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14052"/>
    <dbReference type="EnsemblBacteria" id="EFK56849">
        <property type="protein sequence ID" value="EFK56849"/>
        <property type="gene ID" value="HMPREF0766_14052"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZBYD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063208_0_0_10"/>
    <dbReference type="OrthoDB" id="864360at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107543" evidence="1">
        <location>
            <begin position="23"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="298" mass="34183" checksum="F458396728FDF750" modified="2010-10-05" version="1">MKYWFISVCLGIGILTVQSAHAQKPSGKAMQVWQDSLLSIGNRVFQNPSEPERIDANFRFVKTLVSALKEKNSFDFGFDQLKMISVLNSPDNKFRIFSWNVPLNDGSYLYYGSIQLKTGNGELSLIPLLDKTFEIQQAEQAVVSSSSWYGAQYYEIIQNADHYLLLGWKGHNRLFTQKVIEVLSLKGKEATFGKKLFSDQPQISRKIFNYTRQASMLLRYDAAKKRIVFDHLVPADKSLEGKYQYYGPDLTYDAYEIVPAKLFFKSNIEFTNPVRGDEDQYLNPARKKIEKKSGFNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSX0</accession>
    <name>D7VSX0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_14074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14074"/>
    <dbReference type="EnsemblBacteria" id="EFK56871">
        <property type="protein sequence ID" value="EFK56871"/>
        <property type="gene ID" value="HMPREF0766_14074"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2913">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_3_5_10"/>
    <dbReference type="OrthoDB" id="406005at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="10"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="331"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="456" mass="50060" checksum="228005046BAEB5E4" modified="2010-10-05" version="1">MWATSCEKMLEVDPRQSIDASTALTSPEAITAATNGVYAKLREVSLYGRDLIAIPELLADNAINTGAGNRLIRESNNEIGAHITNWQQSYYGINQINLILDALENIELEANFKNNIKGQNLFLRALLYHNLLRVYAYDPTAIVSASDRGGVPIVLKGVLEVDQIAFASRNTIQEGYKQVYQDLTEASTLIAESNNSKAPAFASRGAVAALFSRVALYNGDYEKAVAEADKAMASGVATFPANAQLISSWRSEKHPESFFEIAFTTADNLGSNESLRATFMTRTTVTSNATASFGNVVVSDDLYAKYSANDTRRGLIMKGLGANASRNEMTKFASKNGVANLDNVPVIRYAEVLLNKAEALANLGKDSDARTALNRIRTRANLAEVSLSGTALMDEIILQRRLELAFEGHRFFDIKRRGKDIIKDAGNVMFNDFRILGRLPIREIEINPNLIQNPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT40</accession>
    <name>D7VT40_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">merR2</name>
        <name evidence="3" type="ORF">HMPREF0766_14144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996019.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14144"/>
    <dbReference type="EnsemblBacteria" id="EFK56941">
        <property type="protein sequence ID" value="EFK56941"/>
        <property type="gene ID" value="HMPREF0766_14144"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166154_0_0_10"/>
    <dbReference type="OrthoDB" id="1654692at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="61"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="120" mass="13670" checksum="9199D917220B72C9" modified="2010-10-05" version="1">MAVSGFVGGNFQNESGNFQMLFIQFTVGSMQLLNYICTFVIKSILILFEMKISGRHIGEMLKEAREQRQLTQEQLAQKVGKKRSYISKVETDYGNNIKLQTLKEIVEKGFDGTVKINLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT52</accession>
    <name>D7VT52_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002978466.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14156"/>
    <dbReference type="EnsemblBacteria" id="EFK56953">
        <property type="protein sequence ID" value="EFK56953"/>
        <property type="gene ID" value="HMPREF0766_14156"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_7_3_10"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="124" mass="14496" checksum="4D494CD90130B168" modified="2010-10-05" version="1">MDNNSCIRQQADIKQINRCKDRVSELNGSFDYLSNGLELAGNNVRLKILFLLYEEKRLCVCDISDILGMTISAVSQHLRKLKDRKLIETEREAQTIFHSLTKEYEKMLKPFFKILDENKILETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT59</accession>
    <name>D7VT59_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_14163</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002978450.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14163"/>
    <dbReference type="EnsemblBacteria" id="EFK56960">
        <property type="protein sequence ID" value="EFK56960"/>
        <property type="gene ID" value="HMPREF0766_14163"/>
    </dbReference>
    <dbReference type="GeneID" id="66690338"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_10"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="304" mass="34071" checksum="33D6B3E5049AABCC" modified="2010-10-05" version="1">MADVVLNNIVKTYNKGEVKAVNDVSFEVNKGELFGLIGADGAGKTSIFRILTTLLLPDSGTASVNGFDVVKDYKAIRKNVGYMPGKFSLYQDLSVEENLNFFATVFNTTVAENYDLVKDIYVQLEPFKNRRAGKLSGGMKQKLALCCALIHRPTVLFLDEPTTGVDVVSRKEFWEMLKGLKQQGITILVSTPYMDEATLCERIALIQNGSIMSIDTPDTIIKQFPDKLFAVKANDMGKLLNALRNNTQIKSCFSFGDFHHITFQNDNERSQNELIQTLQEADFQDIELKHITPSIEDCFINLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTA4</accession>
    <name>D7VTA4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-phytase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996176.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="SMR" id="D7VTA4"/>
    <dbReference type="STRING" id="525373.HMPREF0766_14208"/>
    <dbReference type="EnsemblBacteria" id="EFK57005">
        <property type="protein sequence ID" value="EFK57005"/>
        <property type="gene ID" value="HMPREF0766_14208"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044211_0_0_10"/>
    <dbReference type="OrthoDB" id="1018030at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:3-phytase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003431">
        <property type="entry name" value="BP_Phytase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02333">
        <property type="entry name" value="Phytase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51662">
        <property type="entry name" value="BP_PHYTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107567" evidence="1">
        <location>
            <begin position="24"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="BPP" evidence="2">
        <location>
            <begin position="28"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="362" mass="40216" checksum="99AA2EFD37607E8C" modified="2010-10-05" version="1">MNKLQKINLAVLALALMSQYACQQPGKQRTGSTDSSEVQPAVISEAVQFDSDDPAIWINKEDPSKSLVLGTDKDENGALYVFDLQGKIVKDKVVRNLKRPNNVDLAYGLMLNGKPTDIAITTERFTHKLRIFSLPDMKAVDNGGIPVFEGETGTDYRDLMGIAIYTAPTGKMYAIVGRKNGPKDGYLWQYLLEDNGQGQVKATLVRKFGEYSGKKEIEAIAVDNELGYVYYSDEQTGVRQYYADPEKGNKQLALFATSGFAEDHEGISIYKLTDSTGYILVSDQGANRFQIFSREGTKGNPYAHQLLKTVPVAARQSDGSDVVNVPLNDTFKNGLFVAMSDDKTFHFYRWEDIAGKELKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTA8</accession>
    <name>D7VTA8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996187.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14212"/>
    <dbReference type="EnsemblBacteria" id="EFK57009">
        <property type="protein sequence ID" value="EFK57009"/>
        <property type="gene ID" value="HMPREF0766_14212"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033RCZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_992577_0_0_10"/>
    <dbReference type="OrthoDB" id="1598347at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="282" mass="32140" checksum="D5A42DCE20D22E4D" modified="2010-10-05" version="1">MYLGTTIQGRSDQFIVLEKGDSAADISALMKAENINNIIISGKEVDADVLSNTAFSGVFSEMKIVHLSDIGLDKSEELFQFKNVKRLEIKNCKFKGNESLDWSQLIHLEELFTSYSKRFQNLFTHPALKTLYIEKFEEEGFEFPVNYQLETLSIEKSKDCNWDSLPNFKNLKALYLVSIPSIVDITWITGISQLEDIDFTSCKNMENVIETLSQVKSLKTIFLANTSDFKTLLPLKNLTHLQELNIESSGKLMDKKNIDFLNQMPDLEFSIEMKNCAVSNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTF3</accession>
    <name>D7VTF3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996312.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14257"/>
    <dbReference type="EnsemblBacteria" id="EFK57054">
        <property type="protein sequence ID" value="EFK57054"/>
        <property type="gene ID" value="HMPREF0766_14257"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048863_0_0_10"/>
    <dbReference type="OrthoDB" id="407111at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="93"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="317" mass="36608" checksum="5925E1DC7144EFEA" modified="2010-10-05" version="1">MVKRVGILFGMEDTFPWAFIDKVNELGKGKIIAEPVKIEILEQGADYGYAVIIDRISQDVPFYRAYLKNAAVNGTYIINNPFWWSADEKFFNNALMSKLGIPLPKTVLLPSHERPVNTSETSFRNLSFPHDWEYIFEYVGFPAYMKPHDGGGWRNVYRVENPDDLWNKLGETDQLVMMVQEEIVFEDYYRVYCLGKKYVHIMPYEPRNPHHLRYAAKSQYSGKQLKDLLKTIHDYTITMNQALGYDFNTVEFAVRDGIPYAIDFCNPAPDADKNSVGEENFAWIVEHAAKLAIEKAKEYTPGKPNISWGTFVKDSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTH7</accession>
    <name>D7VTH7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996377.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14281"/>
    <dbReference type="EnsemblBacteria" id="EFK57078">
        <property type="protein sequence ID" value="EFK57078"/>
        <property type="gene ID" value="HMPREF0766_14281"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026364_0_0_10"/>
    <dbReference type="OrthoDB" id="305021at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107282" description="TGc domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="302"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="656" mass="75165" checksum="661DA1CD54D3F620" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTJ8</accession>
    <name>D7VTJ8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996408.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14302"/>
    <dbReference type="EnsemblBacteria" id="EFK57099">
        <property type="protein sequence ID" value="EFK57099"/>
        <property type="gene ID" value="HMPREF0766_14302"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZC64">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046825_3_0_10"/>
    <dbReference type="OrthoDB" id="1802360at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022134">
        <property type="entry name" value="DUF3667"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12412">
        <property type="entry name" value="DUF3667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="231" mass="27081" checksum="50F4FB256D0AE402" modified="2010-10-05" version="1">MKQEKAGNFEDQKLKRINSNYISHEIQHLIHFEKGFPFTIKNLLLRPGKSIREFLFENRDKYVKPVLFLVVSSVVFLLLMSFLHIHLSFFNIDTMEILKGKIRSKEIGAWTNKNMGYSQLIMGIFISLWIKVFYRKYKYNIFEILVLLSFVLGEALLIFAFFIIVANIVQSENVAVFGIIVYFVYIIWAIGQFFGEKKAINYIKSFFVYFLGNATYLATLVSIAYLLKFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTK3</accession>
    <name>D7VTK3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996413.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14307"/>
    <dbReference type="EnsemblBacteria" id="EFK57104">
        <property type="protein sequence ID" value="EFK57104"/>
        <property type="gene ID" value="HMPREF0766_14307"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1894443_0_0_10"/>
    <dbReference type="OrthoDB" id="2051456at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="133" mass="15016" checksum="7610406249D50BB4" modified="2010-10-05" version="1">MLHHSHNRFQSGVFISFAGNCKEALTYYQTCFGGELHFQMMDKHLDGFAKIPVISGSLISDSVTIYGSDLVPDEGRQTGNYLAIFMLCNSAESRKLLLEKLMPIPKKTDAKNDEKIALIEVTDRYDVRWLLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTM4</accession>
    <name>D7VTM4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK55783">
        <property type="protein sequence ID" value="EFK55783"/>
        <property type="gene ID" value="HMPREF0766_14344"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3140833_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="49" mass="6287" checksum="1DD9A6CCB87584FE" modified="2010-10-05" version="1">MYVFRKDHGEWLQHYIQPFKADLFYTIKQMLDEIDQEIFHKEWKWKIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTP5</accession>
    <name>D7VTP5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ExsB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001698.1">
        <property type="nucleotide sequence ID" value="NZ_GL379777.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14365"/>
    <dbReference type="EnsemblBacteria" id="EFK55804">
        <property type="protein sequence ID" value="EFK55804"/>
        <property type="gene ID" value="HMPREF0766_14365"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0603">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081854_1_0_10"/>
    <dbReference type="OrthoDB" id="1681374at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018317">
        <property type="entry name" value="QueC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42914">
        <property type="entry name" value="PTHR42914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06508">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="198" mass="22231" checksum="BB62330DBD5B373B" modified="2010-10-05" version="1">MESLKQGLLLSGGVDSICLAYGLKPDIAYTINYGQIPASREIYVSRYICNLLRIQHKVIEVNCKSLGSGILINEERLDISPSQEWWPYRNQLLITLAAMQAIKDKIGVLHLASVKSDSFHKDGTPQFYDLINELVKYQEGNISIVCESTGYYSHELVKKYNVPLEIIAFAHSCHISNTACGQCPGCKKQIKVRHELSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTT2</accession>
    <name>D7VTT2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="6">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yraL</name>
        <name evidence="6" type="synonym">rsmI</name>
        <name evidence="8" type="ORF">HMPREF0766_14402</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002220.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14402"/>
    <dbReference type="EnsemblBacteria" id="EFK55711">
        <property type="protein sequence ID" value="EFK55711"/>
        <property type="gene ID" value="HMPREF0766_14402"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044779_4_0_10"/>
    <dbReference type="OrthoDB" id="1059309at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018063">
        <property type="entry name" value="SAM_MeTrfase_RsmI_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01296">
        <property type="entry name" value="RSMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK55711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="243" mass="27413" checksum="6FB6649E2DC0C37E" modified="2010-10-05" version="1">MAKYKVPHQRHTSFHKKPLPLTMLYLVPTPIGNLEDMTFRAIRVLKEADLILAEDTRTSAPLLKHFGIDKKVFAHHQHNEHKAVTEIIRFLKEGQQIALISDAGTPAISDPGFLLVRAALKEGLEVQCLPGATAFVPALVNSGLPNDRFCFEGFLPVKKGRQTRLKNLTDEKRTMIFYESPHRLLKSIDEFIAVFGEERQGSISRELSKMYEENVRGTLASLKLHFENNPIKGEFVICIAGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTX8</accession>
    <name>D7VTX8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="10">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">murG</name>
        <name evidence="13" type="ORF">HMPREF0766_14448</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="10"/>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002295.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14448"/>
    <dbReference type="EnsemblBacteria" id="EFK55757">
        <property type="protein sequence ID" value="EFK55757"/>
        <property type="gene ID" value="HMPREF0766_14448"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037404_0_1_10"/>
    <dbReference type="OrthoDB" id="1165736at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01133">
        <property type="entry name" value="murG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="11">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="12">
        <location>
            <begin position="192"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetyl-alpha-D-glucosamine binding" evidence="10">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFK55757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="365" mass="39502" checksum="367A9F42E93A8E04" modified="2010-10-05" version="1">MAKKVIISGGGTGGHIFPAIAIANALLRLDPATEILFVGANGKMEMEKVPAAGYQIEGLDIVGINRQHLWKNIMLPFKLIRSLWQARKIIKKFKPDVAVGVGGFASGPLLMMANRMAIPTLLQEQNSYAGVTNKKLSVKAAKICVAFEGMEQFFPADKILLTGNPIRRASVNIEGKEQEALNAFGLDINKKTILVTGGSLGARTLNDCVKNSLELLKANDVQVIWQCGGYYYDSLQQELKDTLPEQIKMTAFLQRMDYAYAAADCIIARSGAGTISELCVVGKPVIMVPSPNVAEDHQTKNALSLVNKKAAILVRDAEAGEKLITTALQLLNDAERSAELSTNIKKLALLDADDVIAKQVIEIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D7VG86</accession>
    <name>D7VG86_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10005"/>
    <dbReference type="EnsemblBacteria" id="EFK60061">
        <property type="protein sequence ID" value="EFK60061"/>
        <property type="gene ID" value="HMPREF0766_10005"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044440_3_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106911" evidence="2">
        <location>
            <begin position="20"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK60061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="221" mass="24695" checksum="C75232C2BD521CEE" modified="2010-10-05" version="1">MKKLISTSLFAMLFSLSYGQTNIFPEDGNVGIGTLYPDNSQLWDKVLELKGPQHAKLLVTTNAGIKLGMFSHIGYNAKIGTESNTNLTLTAGYWNDVMTLTTSGNVGIGTLQPLEKLSVNGNIRAKEMKVENLNWPDYVFKPSYQLMPLSKIAYFIQENGHLPDVPSAKDVSENGIDLGANQATLLKKIEELTLHMIDMEKNLRKLEKENFEIKEVLKKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGD5</accession>
    <name>D7VGD5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nhaP2</name>
        <name evidence="8" type="ORF">HMPREF0766_10054</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001953.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10054"/>
    <dbReference type="EnsemblBacteria" id="EFK60110">
        <property type="protein sequence ID" value="EFK60110"/>
        <property type="gene ID" value="HMPREF0766_10054"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_8_2_10"/>
    <dbReference type="OrthoDB" id="1194802at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004705">
        <property type="entry name" value="Cation/H_exchanger_CPA1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00831">
        <property type="entry name" value="a_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 6" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="8"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK60110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="527" mass="59123" checksum="A43F172F195A9290" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGE0</accession>
    <name>D7VGE0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10059"/>
    <dbReference type="EnsemblBacteria" id="EFK60115">
        <property type="protein sequence ID" value="EFK60115"/>
        <property type="gene ID" value="HMPREF0766_10059"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_501427_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK60115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="543" mass="62159" checksum="A6AAA1F76A35E0C4" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGG5</accession>
    <name>D7VGG5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative TIGR02646 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002027.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10084"/>
    <dbReference type="EnsemblBacteria" id="EFK60140">
        <property type="protein sequence ID" value="EFK60140"/>
        <property type="gene ID" value="HMPREF0766_10084"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_969402_0_0_10"/>
    <dbReference type="OrthoDB" id="1843957at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK60140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="302" mass="34815" checksum="4F8051B22FA9DB14" modified="2010-10-05" version="1">MRFVIKREEDKTDRLASDETYRALLEITNTRNKDLITDTIYREAYDHPDGKRSRVEDHLSIAYHNKCAYCERICKADIEHYRPKKGVKEDGSHPGYYWLCYEWTNLIPSCITCNREGAKHNKFPVIGPRVSAPVLLVDGSINLALSKAGVDPLLSERPYLLHPEVDHPEDYFEFEIDPNGEGIKIVGIDGEGRGNATIEICLLNRLEVKLDRVERVINDFKDAINALFVKLENGNIDDNQLADRINEHIDLLYIRSQQENRNHTYLSKYIVASDQNFEKIVLPFLPDRTRAIILAAFRAYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGL0</accession>
    <name>D7VGL0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase</fullName>
            <ecNumber evidence="2">3.5.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">amiD</name>
        <name evidence="2" type="ORF">HMPREF0766_10129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.28" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996655.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10129"/>
    <dbReference type="EnsemblBacteria" id="EFK59212">
        <property type="protein sequence ID" value="EFK59212"/>
        <property type="gene ID" value="HMPREF0766_10129"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014322_4_0_10"/>
    <dbReference type="OrthoDB" id="1184688at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MurNAc-LAA" evidence="1">
        <location>
            <begin position="101"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="284" mass="31792" checksum="86D465B06753BCB5" modified="2010-10-05" version="1">MDVKKIFGRTKLIALSLLIIFLILPSTNKSQSKSPYKIKTIVIDAGHGGHDSGARGRETLEKHIALQVALKLGKLIESELPGVKVLYTRKTDEFVELYKRIYYANDNHADLFISIHCNSGGISRVTTRNRKGKRVTSSVTNSSAKGTETLVSGYGRLGEQDAALRENASLLLESNYKDNYQGFDPKDPESYIVFSLMKNQFRDQSIKLASYMQNEYVKSGRTNRGVWEKSLAVLARAGMPAVLTEIGFISNPDEEQFMMSDSGQNEIINNLLNAIKTYKRSVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGM8</accession>
    <name>D7VGM8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996721.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10147"/>
    <dbReference type="EnsemblBacteria" id="EFK59230">
        <property type="protein sequence ID" value="EFK59230"/>
        <property type="gene ID" value="HMPREF0766_10147"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033UNC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1748485_0_0_10"/>
    <dbReference type="OrthoDB" id="1897006at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="149" mass="17283" checksum="EB4AA7B268623707" modified="2010-10-05" version="1">MRKYIFALGLLWIIPFLGLAQSPDKDLPYIRKFVHDLSVDSIATDVLLSQYVTVNKEVDDDYLDYLVASLDEVRLNIQNKNINEIEYLNWNQIPKKETRDIDPEGLDVNSMYFLKYKGRQVVALYLENGKIASFTLVSKGNRTAHFVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGP5</accession>
    <name>D7VGP5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996770.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10164"/>
    <dbReference type="EnsemblBacteria" id="EFK59247">
        <property type="protein sequence ID" value="EFK59247"/>
        <property type="gene ID" value="HMPREF0766_10164"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052345_5_1_10"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="235"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="346" mass="40061" checksum="77C5ED7E032F060F" modified="2010-10-05" version="1">MKLNLDYYLTTDERWLRNFSDTLSEITGYENKIRENSLVLHSEVGEGMFELSTFGDGLSLLRVDCIFHTDLNLNRSPDPKNEEFIIHFNMSEDPVYANNIKNHKKKSWLNFSEAVYYSSSGTGLETRIQQGDHIKLLLFIVDRRWINTNITEKDLIESSIVDQFRNNKCVKGILNMDLVDYNLASEILDLSFPPHAFKLHTHGATLTMLAHLFKKINIREHALKKEISLGTEPFSILKDKLLQQLHRPWPPLETLANEHNMSKTKFIQSFTRILGKNYSQFYLDARMEKSARMILEGISVSMAGMEVGYTNLGHFSKIFKRYYGISPRQYAKQKELILIPTKTTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH04</accession>
    <name>D7VH04_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997061.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10273"/>
    <dbReference type="EnsemblBacteria" id="EFK59356">
        <property type="protein sequence ID" value="EFK59356"/>
        <property type="gene ID" value="HMPREF0766_10273"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_1_10"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="401" mass="43854" checksum="222046A6077E7993" modified="2010-10-05" version="1">MEKSNLSHKELILSILYYNKSHSIADLSIKTRKSIPSISKIINELHFNRLIIEDGLAPSTGGRRPTTYCINSNLDKYILSVAIDQHYSRAVIFNLSNEAQTPVLETENNFNTPDIAFQNIIDLIKTTLEHGSYNSGNILGIGISMPGFVDTAQGTNGSFKDKNENLYNIKHEVENRFQIPTYLENDSTAIAIAEQYFGQAKDTSHALIINIGWGVGLGIIVDNKLFRGYSGYAGEFSHIPLSASDKLCSCGKRGCLEVEASLSAAIQFSEERLQNGEKSILAQRLTDDKPGNSHLLIQSALEGDQLAISALAKSGYMLGKGIATLIHILNPEKIILSGRGSQAGSILMPQIQTAINEFCIPRIARKTTIKVSDLTDKAQLIGSACIVLEYSLSKFANSTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH35</accession>
    <name>D7VH35_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase</fullName>
            <ecNumber evidence="2">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dacB</name>
        <name evidence="2" type="ORF">HMPREF0766_10304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997131.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10304"/>
    <dbReference type="EnsemblBacteria" id="EFK59387">
        <property type="protein sequence ID" value="EFK59387"/>
        <property type="gene ID" value="HMPREF0766_10304"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017692_1_2_10"/>
    <dbReference type="OrthoDB" id="720131at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000667">
        <property type="entry name" value="Peptidase_S13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30023">
        <property type="entry name" value="PTHR30023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02113">
        <property type="entry name" value="Peptidase_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00922">
        <property type="entry name" value="DADACBPTASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00666">
        <property type="entry name" value="PBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="457" mass="50178" checksum="91327586C512E421" modified="2010-10-05" version="1">MINIFAQDPKAIQQAYSTFEQQANLRYGIASLTVLDSKTGNVIFSKNGQTGLPTASTLKVITSATALDLLGPNFTFKTKLYYTGEIDSLGTLKGNIVIEGGGDPTLASPRFEGMNEETLLNKWVYAIQNAGIKCVEGSIIGDDRFFNGHTVPGGWIWTDIGNYYGAGVSGLNWRENSVGVQFKAGNTAGSKATLTSLTVDSSYLDIHNETLTGSKGSGDNVYAYSAPYSTRIYIRGTYGLDLKKTIEIAVPDPAFDAAFQLQKSLRRAGILTENEPLTGKQLTERGETIAKDRKELDVHESPKMQDIVYWFNQKSINLYGETLLKTIGMYSGQKMETADAADMVKKFWKAKLNIPEGELNIVDGSGLSPQNRVTSLAMAKIMNYAKTRNWYEIFYKSLPTYNEMKMKSGTIGGVLGYTGYQTSKAGQEYTFTLLVNNYEGSGSAMRKSMFGLLDILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH46</accession>
    <name>D7VH46_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate binding module (Family 6)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_10315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10315"/>
    <dbReference type="EnsemblBacteria" id="EFK59398">
        <property type="protein sequence ID" value="EFK59398"/>
        <property type="gene ID" value="HMPREF0766_10315"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009397_11_2_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM6" evidence="5">
        <location>
            <begin position="252"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="3">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK59398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="390" mass="43925" checksum="0E8E6CC5EF18FCFD" modified="2010-10-05" version="1">MKDWRVFSTSDLVNWKQETVISPNDNYMGGNSTDCWAGDAAERNGKYYFYFSDRKRSIGVMKSDTPGGKYTDALGKPLVAPMHDPTILTDDDPDKTPYLVYGDKEGGGYHIARLNDDMISLAEAPKPITITGKEWEKAGGWMDKNYIFKYKGTYYLSWGTDYAISKNIYGPYTGAGSTGKGHHLGSLAHSSFFWWKGQFYHVWCYYLKPGYKFRATIITYCHFDNQGRIITDTDFLDKHFATGVGQYDADWPKIEAEWFYEKDSLTRKQSSADGGFELAGMRNGSWLRFANVDMTSSSKQFTAQLAGLSPKGKLEIRTGSINGPLIGTIQSVTNKSKDANQYQILSCKINPPKGKTDIFLVYTDADKKAALSLDWISFNQKTDAHHISNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHE0</accession>
    <name>D7VHE0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinate dehydrogenase cytochrome B subunit, b558 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sdhC</name>
        <name evidence="2" type="ORF">HMPREF0766_10409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997366.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10409"/>
    <dbReference type="EnsemblBacteria" id="EFK59492">
        <property type="protein sequence ID" value="EFK59492"/>
        <property type="gene ID" value="HMPREF0766_10409"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7RU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077968_0_1_10"/>
    <dbReference type="OrthoDB" id="750409at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011138">
        <property type="entry name" value="Cytochrome_b-558"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02046">
        <property type="entry name" value="sdhC_b558_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="257" mass="29185" checksum="500DFF45AEEA5A34" modified="2010-10-05" version="1">MSKSKPVLSSSLGKKLIMSLTGLFLCTFLIVHLIGNLQLFKSDEGLAFNQYAYTMTHFAPIKVVSYLLYASIIIHAIYALVLTLKNKAARPIGYAKYDGAANSAWNSRNMGILGTVLLVFIATHMANFWWKYHNDQTPYIEYKTDLATNVTTSKELSQSEFTDFRIEVKDGVQTIQARDLYKQVDYAFQNVWLVLLYVVAMAALSFHLIHGFQSAFQTVGFNHRKYIPIVRFLGIWVFGVLIPIGFAAMPLYFFFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHH4</accession>
    <name>D7VHH4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpmD</name>
        <name evidence="8" type="ORF">HMPREF0766_10443</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997468.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10443"/>
    <dbReference type="EnsemblBacteria" id="EFK59526">
        <property type="protein sequence ID" value="EFK59526"/>
        <property type="gene ID" value="HMPREF0766_10443"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131047_1_1_10"/>
    <dbReference type="OrthoDB" id="2084745at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_L30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="PTHR15892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="7">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="59" mass="6606" checksum="7F9DE712E28D0996" modified="2010-10-05" version="1">MAKIKITQIKSVIDRSERQKKTIEALGLKRINHSVEVEATPSIIGMVRKVNHLVAIEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHQ2</accession>
    <name>D7VHQ2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10521"/>
    <dbReference type="EnsemblBacteria" id="EFK59604">
        <property type="protein sequence ID" value="EFK59604"/>
        <property type="gene ID" value="HMPREF0766_10521"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZBKJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092723_0_0_10"/>
    <dbReference type="OrthoDB" id="1118154at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12105">
        <property type="entry name" value="HmuY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025921">
        <property type="entry name" value="HmuY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14064">
        <property type="entry name" value="HmuY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="233" mass="25951" checksum="F0F5D63EFC696BB4" modified="2010-10-05" version="1">MNKFRYAIICFTAVILWTGCSKSNDGPNVELSDGTSTVITDLAGDVDASVGNSAPGKEKRDFHTFLFRLSDQKQTWLKTAADSAKYIKGTDWDIAFSGLYNSTLYVNNGQLNGNPAAGNTSRHKVILVKESYDRVNTAPSDADFDKSQLNDFGMIGNEDSQGWYNYNLTNHLVAVVPNRTYVIRLTNGKYAKLQIVNIYKGNPPAVTDLNWPAPYFTFKYFVQEDGSKNLKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHR1</accession>
    <name>D7VHR1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione hydrolase proenzyme</fullName>
            <ecNumber evidence="4">2.3.2.2</ecNumber>
            <ecNumber evidence="4">3.4.19.13</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase large chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase small chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="6" type="primary">ggt</name>
        <name evidence="6" type="ORF">HMPREF0766_10530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Cleaved by autocatalysis into a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="4"/>
    <dbReference type="EC" id="3.4.19.13" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997652.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10530"/>
    <dbReference type="MEROPS" id="T03.001"/>
    <dbReference type="EnsemblBacteria" id="EFK59613">
        <property type="protein sequence ID" value="EFK59613"/>
        <property type="gene ID" value="HMPREF0766_10530"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014813_0_3_10"/>
    <dbReference type="OrthoDB" id="595845at2"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102953">
        <property type="term" value="F:hypoglycin A gamma-glutamyl transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00462">
        <property type="entry name" value="G_GLU_TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106951" description="Glutathione hydrolase proenzyme" evidence="5">
        <location>
            <begin position="27"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK59613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="562" mass="60973" checksum="7B52ED1A742352D1" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHS5</accession>
    <name>D7VHS5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-70 region 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10544</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997682.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10544"/>
    <dbReference type="EnsemblBacteria" id="EFK59627">
        <property type="protein sequence ID" value="EFK59627"/>
        <property type="gene ID" value="HMPREF0766_10544"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_2_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="117"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="181" mass="21173" checksum="AE293667232A4871" modified="2010-10-05" version="1">MKQHDIDEVWKKCKTGDRKSQSLLYQHFAPRMYAVCIRYAVDTLEAEDMLQTGFIKVFAKHHLFDERGSLEGWIRRVMVNTAIEIHRKNKVSFCDIDENLQAHMLKSSIGTDQSAYQDLMQLVKQLPVGYRTVFNLYAIEGYTHHEIAKSLHISEGNSKSQLSRARTWLKDKLQKLEETER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHW3</accession>
    <name>D7VHW3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997792.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK59665">
        <property type="protein sequence ID" value="EFK59665"/>
        <property type="gene ID" value="HMPREF0766_10582"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063037_0_0_10"/>
    <dbReference type="OrthoDB" id="1806453at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20169">
        <property type="entry name" value="Peptidase_M90_mtfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010384">
        <property type="entry name" value="MtfA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042252">
        <property type="entry name" value="MtfA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30164">
        <property type="entry name" value="PTHR30164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06167">
        <property type="entry name" value="Peptidase_M90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="265" mass="30205" checksum="75AE90208B4CFDCD" modified="2010-10-05" version="1">MQYNPVVVVIIIFIIGVVLVYYVMKNVSNKKIVVDNQSVSLDEIQQVLLEEVGFYKGLNPDEQLKFCNRVSYFLNTTRISAEKGVQIVNADKILVAASATIPLFHFENWSYENLDEVLIYPGTFSEKFDTEEGDRNILGMVGDGVLGRKMILSLSALRNGFRSGSGENTAIHEFVHLIDKADGETDGIPEYLIPKSLIHPWLKEMHKTISMIKRDKSDIREYAATNEAEFLAVTSEYFFQKPKLLKEDHPELFELLTEIYEKKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHW8</accession>
    <name>D7VHW8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperonin GroEL</fullName>
            <ecNumber evidence="6">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Chaperonin-60</fullName>
            <shortName evidence="6">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">groL</name>
        <name evidence="6" type="synonym">groEL</name>
        <name evidence="10" type="ORF">HMPREF0766_10587</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997806.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10587"/>
    <dbReference type="EnsemblBacteria" id="EFK59670">
        <property type="protein sequence ID" value="EFK59670"/>
        <property type="gene ID" value="HMPREF0766_10587"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016503_3_0_10"/>
    <dbReference type="OrthoDB" id="265347at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK59670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="545" mass="57690" checksum="E5DBC5DFD8727D72" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHY3</accession>
    <name>D7VHY3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10602"/>
    <dbReference type="EnsemblBacteria" id="EFK59685">
        <property type="protein sequence ID" value="EFK59685"/>
        <property type="gene ID" value="HMPREF0766_10602"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3222236_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="44" mass="5166" checksum="0F98C11D7E797715" modified="2010-10-05" version="1">MCISFTNTDTWLSYYQGNRRFTPAEHNALSYKQTKKGSCFSRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI15</accession>
    <name>D7VI15_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative bacteriocin export ABC transporter, lactococcin 972 group</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_10634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997900.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10634"/>
    <dbReference type="EnsemblBacteria" id="EFK59717">
        <property type="protein sequence ID" value="EFK59717"/>
        <property type="gene ID" value="HMPREF0766_10634"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_10"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="224" mass="25350" checksum="4612CF7664A63F73" modified="2010-10-05" version="1">MIKIHQLKKFYRTDEIETLALNNVDVHVTEGEFVAVMGPSGCGKSTLLNVLGLIDDFEEGSYLFNETEVAKFNESKRSDLRKHAIGFVFQSFNLIDELTVYENVELPLIYTNVPAAERKKRVEEVLEKVQIAHRRNHFPQQLSGGQQQRVAVARAVINNPKLILADEPTGNLDSNNGNEVMQLLTELNESGTTIIMVTHSEHDAKFAHRVIRMLDGEVIMETQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI33</accession>
    <name>D7VI33_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">ndk</name>
        <name evidence="4" type="ORF">HMPREF0766_10652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997935.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10652"/>
    <dbReference type="EnsemblBacteria" id="EFK59735">
        <property type="protein sequence ID" value="EFK59735"/>
        <property type="gene ID" value="HMPREF0766_10652"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060216_8_1_10"/>
    <dbReference type="OrthoDB" id="1752581at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="3">
        <location>
            <begin position="3"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="139" mass="15154" checksum="AFDB68B6A6BBE448" modified="2010-10-05" version="1">MATNRTFTMIKPDAVANGHIGAILNDIISGGFKIVALKYIQLTNESAGNFYAVHKERPFYGDLVSFMTSGPIVAAILEKDNAVEDFRTLIGATNPAQAAEGTIRNKYAKSIDANAIHGSDSDENAEIEGNFFFSQFERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI54</accession>
    <name>D7VI54_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative alpha-1,2-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_10673</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997977.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10673"/>
    <dbReference type="EnsemblBacteria" id="EFK59756">
        <property type="protein sequence ID" value="EFK59756"/>
        <property type="gene ID" value="HMPREF0766_10673"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003690_2_2_10"/>
    <dbReference type="OrthoDB" id="100818at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="Alpha_mannosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107256" evidence="2">
        <location>
            <begin position="25"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92N" evidence="4">
        <location>
            <begin position="32"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92" evidence="3">
        <location>
            <begin position="298"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="769" mass="87144" checksum="412E4EDB1333706F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI73</accession>
    <name>D7VI73_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10692"/>
    <dbReference type="EnsemblBacteria" id="EFK59775">
        <property type="protein sequence ID" value="EFK59775"/>
        <property type="gene ID" value="HMPREF0766_10692"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1044693_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="253" mass="29636" checksum="50EDD65506DBCDDD" modified="2010-10-05" version="1">MMKEDIKIDFAIIDDVESIVSLVRSSFDKSYLEISIYKCKGIASFIITELNNQYSPYKYLVAKIGDKIVGFVEFKMFPHNSTAFLNMIATDNTHKGLGIAKKIFSYSENYFREQLYSNIQLDVFQSNEVARQWYEKMGFVKEESSYFCQQHIGDASKHIQDILILNLSQFNCLYEKFGFSFLQMSAGEQSFTLGIIDENIIIREDKISEEILVAVKSFFKDYNFKMIYYKGQDKNLEKYKYIGEIHRMKLTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIA7</accession>
    <name>D7VIA7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">trmB</name>
        <name evidence="2" type="ORF">HMPREF0766_10726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998084.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10726"/>
    <dbReference type="EnsemblBacteria" id="EFK59809">
        <property type="protein sequence ID" value="EFK59809"/>
        <property type="gene ID" value="HMPREF0766_10726"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050910_2_2_10"/>
    <dbReference type="OrthoDB" id="1025521at2"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="195"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="217" mass="25391" checksum="ACD66DD8841D6400" modified="2010-10-05" version="1">MGKDKLRKFAEVSTFKNVVQLDEGKDLKGKWGSQHFGNNNPIVLELACGKGEYTVNLAKLFPQKNFIGIDYKGNRIWRGAKTALEEGIDNVGFLRIQIETILEHFEENEVDEIWITFPDPQPQDSREKKRLTNPKFLERYQYIMKPDGLMHLKTDNDGFYAYTLDQIDVLGLTKEAQTDDLYHSELVDDVLSIKTYYEKKYLAHNKNINYVRWTFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VID9</accession>
    <name>D7VID9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">comB</name>
        <name evidence="4" type="ORF">HMPREF0766_10758</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998145.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10758"/>
    <dbReference type="EnsemblBacteria" id="EFK59841">
        <property type="protein sequence ID" value="EFK59841"/>
        <property type="gene ID" value="HMPREF0766_10758"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_7_2_10"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="63" mass="6963" checksum="7ED5B6C54605C862" modified="2010-10-05" version="1">MNTGTVKFFNETKGFGFITPQDGSADVFVHTTGLKNQVREGDEVTYEVERTPKGLNAINVRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIF3</accession>
    <name>D7VIF3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK59855">
        <property type="protein sequence ID" value="EFK59855"/>
        <property type="gene ID" value="HMPREF0766_10772"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZC5W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046395_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032560">
        <property type="entry name" value="DUF4932"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16286">
        <property type="entry name" value="DUF4932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="387" mass="45540" checksum="A6608384FC51DF88" modified="2010-10-05" version="1">MQKQSDSMKTIILFLTTILYLYPSIPVFGQQKDLNFDAAYKKQNDQKVTIEINELQELAYIILSLTDIAKNNKVMTDQGTEYYREIIAHFTPYAGHEVVHKFNTLLSENIINYFILAGNAYGFRFEKDKIVPTGIYNFPAKGVGKFEAETNPIITYINDLEDFAKKSKFRKFYKDHNRFYNDLKKEYHTFAAIDEQKKWLEKEFDYNINSYRVLTSPLIGGMNATHTFEDNDFKETLLFLPTIKKDKEWTENYRKAINTRIIFTEIDHNYVGPVSENNKEKINSIFDNRAKWVDSTNRSTQHYPTPVKVFDEYLTWGLFLLYAHDLFPDDQVVFNQMVENVNTMMISKKGFPKAKEFNEELLKLYMEHKDKGIASLYAPLLEWSARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIT1</accession>
    <name>D7VIT1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998433.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10900"/>
    <dbReference type="EnsemblBacteria" id="EFK59983">
        <property type="protein sequence ID" value="EFK59983"/>
        <property type="gene ID" value="HMPREF0766_10900"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2262044_0_0_10"/>
    <dbReference type="OrthoDB" id="2044055at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="103" mass="11807" checksum="AB6C1FCCA0FC9268" modified="2010-10-05" version="1">MKNLEHQTKQAFLFSLAFYVIGLLACFINIQFATLIISVSLLISLIWVFLVLREIFLSGRISNVERLGLAIFIVMGNILAGAVYFWFLRNRVIHSAVKNKFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIX5</accession>
    <name>D7VIX5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">GTP cyclohydrolase 1 type 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998525.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10944"/>
    <dbReference type="EnsemblBacteria" id="EFK60027">
        <property type="protein sequence ID" value="EFK60027"/>
        <property type="gene ID" value="HMPREF0766_10944"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037423_1_0_10"/>
    <dbReference type="OrthoDB" id="502462at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017221">
        <property type="entry name" value="DUF34/NIF3_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037489">
        <property type="entry name" value="UCP037489_NIF3_YqfO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR037489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK60027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="365" mass="40674" checksum="BE2E4C5B8DCD022F" modified="2010-10-05" version="1">MKIFELTNYLESIAPLAYQESYDNSGLLVGSPGDEIHRALISLDCTEAVVDEAIAEGCDIIISHHPIVFGGLKKFTGSNYVERVIIKAIRNNIAIYAIHTNLDNIFGGVSSKIAEKLHLENTAILKQKKNLLNKLVVYVPRTHVEIVRDALFEAGAGNIGNYDQCSYNSAGYGTFRPLEGADPAIGEIGQQERVEETKIEVIYPQIKEREILVAMYASHPYEEVAYNIVTLQNNYQTIGSGVIGNLSEPMSEIDFLRYLKEKLNLTVIRHTELRGKEVSRVAVCGGAGGFLLADAKRSGADFFVTADYKYHEFFDAEGQIVIADTGHFESEQFTQELLLEIIRNKFANFAVLITETDTNPIKYYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIX6</accession>
    <name>D7VIX6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative zinc ribbon domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998527.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10945"/>
    <dbReference type="EnsemblBacteria" id="EFK60028">
        <property type="protein sequence ID" value="EFK60028"/>
        <property type="gene ID" value="HMPREF0766_10945"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073076_2_0_10"/>
    <dbReference type="OrthoDB" id="833439at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003743">
        <property type="entry name" value="Zf-RING_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02591">
        <property type="entry name" value="zf-RING_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-RING_7" evidence="2">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK60028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="249" mass="28877" checksum="19B426D2B31E00F9" modified="2010-10-05" version="1">MEQTVEQKLKALWSLQTIHTKVDKIRQIRGELPIEVADLEDEIAGLETRIEKIRTDLDELEDSIVKRKNMIKDAQGAIKKYEGQLNEVKNNREYDAITKEIEIQGLEIQVCEKRIKEYEFEIRNKTEQYESTEKTLAYNKTELEGKRKELDTITAETQKEEDALLKNAEAAEKNIEERLINVYNRLRNSFKNGLAVVSIDRDSCSGCHNKIPAQMQSEIRQRKKIIICEHCGRVIVDEGILLEVEGEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ69</accession>
    <name>D7VJ69_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0382 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000399.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11038"/>
    <dbReference type="EnsemblBacteria" id="EFK58922">
        <property type="protein sequence ID" value="EFK58922"/>
        <property type="gene ID" value="HMPREF0766_11038"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096548_3_3_10"/>
    <dbReference type="OrthoDB" id="1985942at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="PTHR43461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="129" mass="14077" checksum="2D966CDAF8CFE2C8" modified="2010-10-05" version="1">MNKQIILTASFFGLIAVALGAFGAHGLEGKISEDHIGTWKTANQYHFYHTFALLFLSTFSRAKNTSIRVAFFAFTIGILLFSGSLYILSVREITGFGNPRILGPITPLGGLSYMIGWVGLFVAALKNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJB4</accession>
    <name>D7VJB4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase, group 2 family protein</fullName>
            <ecNumber evidence="4">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11083</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000536.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11083"/>
    <dbReference type="EnsemblBacteria" id="EFK58967">
        <property type="protein sequence ID" value="EFK58967"/>
        <property type="gene ID" value="HMPREF0766_11083"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_24_0_10"/>
    <dbReference type="OrthoDB" id="1445278at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="8"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_transf_7C" evidence="3">
        <location>
            <begin position="165"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="271" mass="31618" checksum="788D545102F30960" modified="2010-10-05" version="1">MTNKTKISLLISTYNWPEALHLCLESILLQTILPDEIVIADDGSREETREEIEKFRLRTNISIQHIWHEDNGFQLSQIRNKAISQVSNPYIIQIDGDVILHSCFIQDHLIISEQNAFITGSRVNLDENFSKKMLLRGVLPDLHTLRYKSKNILNSLHIPFLAKIFADKYKVNGRYRDFTRGCNMAYWKDDIIKVNGYNESMHGWGSEDKELVARLRNLGLKKRFLKFSGIVYHIWHPFASREKEIVNDSIYKSTVSQNKTFTENGINKYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJI7</accession>
    <name>D7VJI7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sigma factor regulatory protein, FecR/PupR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000669.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11156"/>
    <dbReference type="EnsemblBacteria" id="EFK59040">
        <property type="protein sequence ID" value="EFK59040"/>
        <property type="gene ID" value="HMPREF0766_11156"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050192_1_0_10"/>
    <dbReference type="OrthoDB" id="1381035at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FecR" evidence="1">
        <location>
            <begin position="182"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="391" mass="43877" checksum="20549080028A312E" modified="2010-10-05" version="1">MTDEQIHDLFRKYYDKTASEKERQQLFHWFSNQDNREKAEELLLLHYNDEFEAQDNSLPQIDPHAVIQSILATKPVSVATSKKIRWIKPLSIAASILIVLGIYFFSQNHTPQPLITDATTYDIPAGGNKAILTLSNGNKVILDSLSEGAAIEEGNIRITKSNDGQVTYSVRSASTSRLTFNTIETPVGGFYQILLPDGTRVWLNALSSLKFPTSFTSGSRKVQLKGEAYFEVAKDKSKPFIVDVNDMQVTVLGTHFNINSYSPQSAIYTTVLEGAVAVSKSNLKKTVLPGQQLQYSGANMMKLENNVDLDQIMAWKDGYFTKKSISLNALMAEVARWYGVDIVYSEPIQAEFVMKLPKDISLKELITVLELTEEVKFDLNLKTLKVMKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJM6</accession>
    <name>D7VJM6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11195"/>
    <dbReference type="EnsemblBacteria" id="EFK59079">
        <property type="protein sequence ID" value="EFK59079"/>
        <property type="gene ID" value="HMPREF0766_11195"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3222238_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="44" mass="5258" checksum="5EF98AF6CEB4977E" modified="2010-10-05" version="1">MQKVLKISFCCKSLENPVYQLLAKNNVSIFPLLYQFFDWLFTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJN3</accession>
    <name>D7VJN3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11202</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11202"/>
    <dbReference type="EnsemblBacteria" id="EFK59086">
        <property type="protein sequence ID" value="EFK59086"/>
        <property type="gene ID" value="HMPREF0766_11202"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_1_4_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="61"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="307"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="427" mass="47476" checksum="D206AFD32584F63B" modified="2010-10-05" version="1">MGQIAQDQFFNSETNANAAVLGAYRTMMNSFSFGQSIVIVPEFSAGHVRHSASFPEYQNFAEHKIQAINPWTANMWQAVYATINAANQIIEEVPNMTPAMITGEKKNIFVGEAKFIRALNYFFLVRAFNKVPLKLTYTKEGDNFDIPESGKEAIYTQIVNDLTEAVAALPQANPNTGDAAKGRASYWAAKALLAKVYLYQAAFTNDYKKAADLANEIITTAGFGLVTDFSTIWTTQNTNEAIFEIQFDDQATNPLAAVANDNASVLFFAKDSTIQDLYSPQDKRRAFTVKKGSKNNYFMGKFPNFSPASQNLTVIRLAEIYLIHAEAQARVDNSVSTAAYNSLKAVQDRAGVTVPISTYSNLEAFITAVQEEKEKELMFEGETWFDYSRTKLALRKYDTLTDERYLLYPIPSAQIALGTGLTQNPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJX9</accession>
    <name>D7VJX9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998724.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11298"/>
    <dbReference type="EnsemblBacteria" id="EFK58581">
        <property type="protein sequence ID" value="EFK58581"/>
        <property type="gene ID" value="HMPREF0766_11298"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084727_0_0_10"/>
    <dbReference type="OrthoDB" id="1589192at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="285" mass="32562" checksum="9BC686DE18ED1031" modified="2010-10-05" version="1">MIAVVFSGSRYADWRLADKSRVVSGFRTTGINSYIQDERFITQLLNKNTNLINYAEKIKRIYFFGAGASSLERQSKIKKVFESFFKNAKVKVNHDVLASAISTFGDEKGIIGILGSGSNAAYYNGRKILKNNFGMGYILADEGSTNWIGRQLLKDFLSGTMPVDIREKLLSRYNLDRKIILEKVYNHPNPNIFLTSFADFVQENKDEPYLSTIIKEGLFLYCDTYLVPLSERYPDHKINFTGSVATHYADWLRDIGENEFGLEIGTIIKEPIHNLVKYYLNLNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJY3</accession>
    <name>D7VJY3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998739.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11302"/>
    <dbReference type="EnsemblBacteria" id="EFK58585">
        <property type="protein sequence ID" value="EFK58585"/>
        <property type="gene ID" value="HMPREF0766_11302"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050517_1_0_10"/>
    <dbReference type="OrthoDB" id="580619at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="315" mass="36488" checksum="074566894E5A9340" modified="2010-10-05" version="1">MPDILADFLVRRPEGYYCRYGDFYIDALEPVRIDVVSHAHGDHATKGHAQIIATEATAAFMQYRYSKQPLHTFLVKRFEESFNIAEVVLTFIPAGHILGSAQILMEYKGVRYLYTGDYKVDADPTCEPIHIVKADVLITESTFANPEVSHPDAVAEILKLKDRPFNILLGCYALGKAQRITALLNQHCPERHVLVHHNILPFHRIYDQLGNFPMKYEPYNRQVMKHGEPDKVYLVPPMTFNSYFRATKVQRAFASGWKRLQQHNDIELYISDHVDWQDILDYVDQVQPRQIWTIHGDGRLLKEYYGTNLDVRDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK64</accession>
    <name>D7VK64_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998968.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11383"/>
    <dbReference type="EnsemblBacteria" id="EFK58666">
        <property type="protein sequence ID" value="EFK58666"/>
        <property type="gene ID" value="HMPREF0766_11383"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032RYV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2059254_0_0_10"/>
    <dbReference type="OrthoDB" id="1574405at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="119" mass="13895" checksum="32FADB973A925D63" modified="2010-10-05" version="1">MENKDRVINRVGWVTQMKSTPPLTGEYIQRQYRFFENQVHFLQDNGFTTRTILKAGEKATNDSQITVGDLTPLGLKFYLFGIRPWTARYDRNKDKDKAVDDLSFINKKLTDFIKMNGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK68</accession>
    <name>D7VK68_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998980.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11387"/>
    <dbReference type="EnsemblBacteria" id="EFK58670">
        <property type="protein sequence ID" value="EFK58670"/>
        <property type="gene ID" value="HMPREF0766_11387"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033HXM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1904464_0_0_10"/>
    <dbReference type="OrthoDB" id="1992727at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="135" mass="15391" checksum="F73E4EC614BF4D4F" modified="2010-10-05" version="1">MRNRNYIPSAFNLRTLVAAAVPSYVFPALMSFLSGYFLQKTELMRASYTTIGLSSLLSTLFSFIILWQFESRQILVQNKLIRSLIVVFLMISLGIFCTSLLNLPSECFNITFSAFLGAVILTARQHMKNYKDEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKJ3</accession>
    <name>D7VKJ3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999324.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11512"/>
    <dbReference type="EnsemblBacteria" id="EFK58795">
        <property type="protein sequence ID" value="EFK58795"/>
        <property type="gene ID" value="HMPREF0766_11512"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1626023_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107615" evidence="2">
        <location>
            <begin position="20"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="163" mass="17575" checksum="EC857DDC6D7E97C6" modified="2010-10-05" version="1">MKKLIFTGLLLTCLATVSAQIVVNPDGTHSVVSGSHIINSNGTVSAIHGDHIISSDGSISAIHGNHIVNSNGTISAIHGSHIINMNSGTISVVQGVYPLHENGSLNLLQSNLLLPEISPSNQKKYSFNPFKMVNYSDSLRTYDPTSKETRSKKRIKLSKKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLB3</accession>
    <name>D7VLB3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999960.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11782"/>
    <dbReference type="EnsemblBacteria" id="EFK58386">
        <property type="protein sequence ID" value="EFK58386"/>
        <property type="gene ID" value="HMPREF0766_11782"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062228_0_0_10"/>
    <dbReference type="OrthoDB" id="1533499at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021314">
        <property type="entry name" value="DUF2911"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11138">
        <property type="entry name" value="DUF2911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107014" evidence="1">
        <location>
            <begin position="21"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="278" mass="30912" checksum="F37F826F698FAFE5" modified="2010-10-05" version="1">MKKSILTLLVASALAFGAQAQLKIPQPSSATEVTQAIGIHNVVLKYSRPNTNGRTIFGDLVPYGQVWRTGANTVSTLTFEEEVTIQGTKVPAGTYGIFTIPNKNEWTIILSKNSKQWGAYTYKQEEDLVRFNVKPTTLANKVETFTISFDQVTTTSGVVSIAWDKVSVQFNIKVDQSKEILASIDQAMQGEKKPYFQAALYYFNNNLDIKKAVEWVNIADQGNTEAPWIKYWKSQILLKSGDKKGAEETAQQGIDMAKAGKNDEYIKLNTQALNNAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLI7</accession>
    <name>D7VLI7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, DeoR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_11857</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000159.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11857"/>
    <dbReference type="EnsemblBacteria" id="EFK58460">
        <property type="protein sequence ID" value="EFK58460"/>
        <property type="gene ID" value="HMPREF0766_11857"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060699_2_1_10"/>
    <dbReference type="OrthoDB" id="1629121at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="247" mass="27289" checksum="D563B06B0AD54D09" modified="2010-10-05" version="1">MLKEERQAYIIHQINLHNKVLSSDLSVQLNVSEDTIRRDLNELAENGQVLKVYGGALSKSFQFPFQDGNVYAKESKKEIARKSISLIQNGMTVLVGGGTTVIELARIIPEDIQCTFFTISPLVALELAEKENIEVISIGGKLSRNTNIVTGAQVINELSEIKVDLCILGTNSLSIDDGITDSDWEVVQIKRAMIKCSHKVAILSIAEKLNSNQKMKVAPLRDVSFLVTDLTPDHPSLKEFAKTIKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLL9</accession>
    <name>D7VLL9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0766_11889</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000221.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11889"/>
    <dbReference type="EnsemblBacteria" id="EFK58492">
        <property type="protein sequence ID" value="EFK58492"/>
        <property type="gene ID" value="HMPREF0766_11889"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085305_0_0_10"/>
    <dbReference type="OrthoDB" id="1537812at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK58492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="183" mass="20359" checksum="A23E76EB30B7E5A6" modified="2010-10-05" version="1">MAELNQDSGKQGKGGKVRSKKNGGKVDLTAMVDLAFLLITFFMLTTSLNKPQAMDVAMPDKNKMDATDNLEIADNRSITLLLGSDNKILWYYGQLKSPITPPTAIDYGKDGLRKVITEMKARVPAAAGGKDLIVVIRPSEKSVQRNLVDVLDEMKIVDIKRYMISKITPEEIDVLKRENLYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLM5</accession>
    <name>D7VLM5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 17" type="primary">metK</name>
        <name evidence="17" type="ORF">HMPREF0766_11895</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000237.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11895"/>
    <dbReference type="EnsemblBacteria" id="EFK58498">
        <property type="protein sequence ID" value="EFK58498"/>
        <property type="gene ID" value="HMPREF0766_11895"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041802_1_1_10"/>
    <dbReference type="OrthoDB" id="1024388at2"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="3"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="113"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="244"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="241"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="256"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFK58498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="417" mass="46055" checksum="D8B70D521FAFA1AD" modified="2010-10-05" version="1">MAYLFTSESVSEGHPDKVADQISDALIDNFLAWDQDARVAIETLVTTGQVVLAGEVKSKIYLDVQKIARSVIEKIGYTKSAYMFEANSCGILSAIHEQSADINQGVDRKTKQEQGAGDQGIMFGYATNETENYMPLALDLSHRLLYELADLRRENKEITYLRPDAKSQVTLEYDSNHKPVRIDTIVISTQHDDFDEESTMLNKITEDIKAILIPRVKAQLKPELQSLFDDKIKFHINPTGKFVIGGPHGDTGLTGRKIIVDTYGGKGAHGGGAFSGKDPSKVDRSAAYATRHIAKNLVAAGVAEEILVQVSYAIGVKDPMGVYVNTYGTSKVNLTDGQIAQKISELFDMTPYGIETRLGLRNPIYSETAAYGHMGRTPRSVTKTFENSNGEQKTVEVDLFTWEKLDFVDQIKAAFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLR6</accession>
    <name>D7VLR6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, GntR family</fullName>
            <ecNumber evidence="3">2.6.1.39</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.39" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000007">
        <property type="protein sequence ID" value="EFK58218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000949.1">
        <property type="nucleotide sequence ID" value="NZ_GL379775.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11936"/>
    <dbReference type="EnsemblBacteria" id="EFK58218">
        <property type="protein sequence ID" value="EFK58218"/>
        <property type="gene ID" value="HMPREF0766_11936"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_1_10"/>
    <dbReference type="OrthoDB" id="1320028at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="495" mass="56314" checksum="B0C94064DFB69C13" modified="2010-10-05" version="1">MASPVSVPYQSFIQIDRNLDCSVYLQISNQLINAIQRGFLTAGTKLPGTRTLGNLLQIHRNTIVAAYDELHAQGWVDMRPNQGTFVLVKSDDKPYKIRSAQQNQLAVYPSSTGYSFRKSILLDNPFEHSACEYVFNDGIPDIRLTQIDHLSSLYSANLKRKSNHKKLGYYNHDGSEYFKKNLSNYLNLSRGLHISKDNILITRSTEMSVYIASEILLSAGELVLVGEMSYFSVNMIFQKSGAHIMSVPIDEEGIDVDAVREICERQQVRMLYITPHHHYPTTVTLSAERRIALLDLASQFGFIILEDDYDYDFHYDKAPVLPLASADTNGMVVYIGSFGKSLAPGFRTGFIVAPQNLMIEMRKHLGIIDRQGDIMMEQVLGEMIEEGDIHRYLKKSLKVYQERRDYFASLLEQHLHEYLDFRKPSGGLAVWATWKQPINLLQLSRSCARNNLFIPRTLLYQNVSITATRLGFGHFTTAEMEESIAILYQAVLSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM34</accession>
    <name>D7VM34_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OmpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001256.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12031"/>
    <dbReference type="EnsemblBacteria" id="EFK58039">
        <property type="protein sequence ID" value="EFK58039"/>
        <property type="gene ID" value="HMPREF0766_12031"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014978_0_0_10"/>
    <dbReference type="OrthoDB" id="583204at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="3">
        <location>
            <begin position="529"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="650" mass="72858" checksum="411C104029776E71" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM36</accession>
    <name>D7VM36_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12033"/>
    <dbReference type="EnsemblBacteria" id="EFK58041">
        <property type="protein sequence ID" value="EFK58041"/>
        <property type="gene ID" value="HMPREF0766_12033"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3222239_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="44" mass="4761" checksum="509B3F7D3DD1CDBA" modified="2010-10-05" version="1">MTGLTVVNSLAQVCCLCLYMLPVWTPTNAVEASVGVPANSMRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM70</accession>
    <name>D7VM70_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001351.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12067"/>
    <dbReference type="EnsemblBacteria" id="EFK58075">
        <property type="protein sequence ID" value="EFK58075"/>
        <property type="gene ID" value="HMPREF0766_12067"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2928">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068050_4_1_10"/>
    <dbReference type="OrthoDB" id="1305123at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007462">
        <property type="entry name" value="COV1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31876">
        <property type="entry name" value="PTHR31876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04367">
        <property type="entry name" value="DUF502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="198" mass="21933" checksum="F759C1715FF05351" modified="2010-10-05" version="1">MFSKIFRGFLNYLIKGTLVMVPLAGAIFLIVWIVASVDSTLNLTEHFLEDESGHPLYIPGIGILTVILILVLAGVIFTNFVTDPIKQWITRQINRIPLFNTLYSSIKDFTEAFVGDAKKFNEPVLVTVNDMGLKKIGFLTQHDLSKLNLPDDVIVYFPYSYSFAGQVVIVKADKVEKLNMSATDAMKLVVSGGVSGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM80</accession>
    <name>D7VM80_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001362.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12077"/>
    <dbReference type="EnsemblBacteria" id="EFK58085">
        <property type="protein sequence ID" value="EFK58085"/>
        <property type="gene ID" value="HMPREF0766_12077"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8DB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024790_0_0_10"/>
    <dbReference type="OrthoDB" id="248458at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038636">
        <property type="entry name" value="Wzi_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107329" evidence="1">
        <location>
            <begin position="29"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="546" mass="63085" checksum="BCD574CE3C700358" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMD3</accession>
    <name>D7VMD3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001460.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12130"/>
    <dbReference type="EnsemblBacteria" id="EFK58138">
        <property type="protein sequence ID" value="EFK58138"/>
        <property type="gene ID" value="HMPREF0766_12130"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_10_0_10"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005672227" evidence="2">
        <location>
            <begin position="31"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="445" mass="50871" checksum="AF6C86FC22F02373" modified="2010-10-05" version="1">MVFQMKINMKSNKIILSILATTALFNWAFAQQVPQKATLQQLIDYALQNKISIKQAEIDEAIGEKDIDISLSGWYPQLALTGNYNHNLKIPTNAFGGQTVVMGQKNSSNLTLQADQQLLNPALMQASKAAELTRLSNKQNTENVRINTVVDVSKAYYDILTSEEQINIVRENIIRLDKQLKDAQVRYEVGLVDKTDFKRAQIALSNARADEKRTVELRKYKYDYLKQLLALDIKDPLTLSFDNANMETEILLDTTGGLDNSKRIEFQQLETAKKLQQLNTQYYKWTYLPSLSAFINYGLDYRNDKFGDLYNDSFPRSTVGLNLTFPIFQGFKRKNQINKSQLQEARIDWDIQNLNNQISTEYSLAKASYNANLSDWKTSKDNVDLSKEVYNTIKLQYDEGIKTYLDLMTAETDLKTSQLNYLNALYALLSSKLDVQKALGNIQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMD8</accession>
    <name>D7VMD8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycerol-3-phosphate acyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Acyl-PO4 G3P acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Acyl-phosphate--glycerol-3-phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">G3P acyltransferase</fullName>
            <shortName evidence="10">GPAT</shortName>
            <ecNumber evidence="10">2.3.1.275</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lysophosphatidic acid synthase</fullName>
            <shortName evidence="10">LPA synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">plsY</name>
        <name evidence="11" type="ORF">HMPREF0766_12135</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:34075"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="2.3.1.275"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably interacts with PlsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the PlsY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.275" evidence="10"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001465.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12135"/>
    <dbReference type="EnsemblBacteria" id="EFK58143">
        <property type="protein sequence ID" value="EFK58143"/>
        <property type="gene ID" value="HMPREF0766_12135"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081254_4_0_10"/>
    <dbReference type="OrthoDB" id="1691856at2"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01043">
        <property type="entry name" value="PlsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00023">
        <property type="entry name" value="TIGR00023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK58143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="216" mass="23356" checksum="E7DE374B08C1911A" modified="2010-10-05" version="1">MISIYLLGIVILAYLFGSIPTAVWLGQAFYGVDVREYGSGNAGATNTFRVLGPKAGSAVMFIDILKGWTATNLPHLLDPTIVGMPEAPQFVNFQLALGVIAVLGHLFPIFAGFRGGKGVATLFGMVLAIHLPAALCCVSIFILTLLITHYVSLSSILAGFTFPFSIAFIFHTSVPSVLLYGIAICALILITHQKNIERLLKGHESKIYLFRKKNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VME6</accession>
    <name>D7VME6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12143"/>
    <dbReference type="EnsemblBacteria" id="EFK58151">
        <property type="protein sequence ID" value="EFK58151"/>
        <property type="gene ID" value="HMPREF0766_12143"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50330NM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1160504_0_0_10"/>
    <dbReference type="OrthoDB" id="2054859at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="239" mass="27345" checksum="A3AA63ABE7FD512F" modified="2010-10-05" version="1">MIITIITYFDDSVFENINNRKFLLKLYHLTEMNFKIIVPFLLTGICLSAGCQSNSNIKNTSQSDTAIALKADSTTGKDTITATVDDCIFDNDMERLTKDAVSEFDPALKGVWDTTTHQLTVNLRNGDRLQLMIGGCNHFIYDAYLETDIPFENTSELLQKMVWITSSFFGKGYGEDYQRIVDKKQYQLSRTEIDDNKDTVHYYDITEPSAEPDNMIREGFYLYDKGQKGAAIRVSFYMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMN9</accession>
    <name>D7VMN9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12259</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992715.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12259"/>
    <dbReference type="EnsemblBacteria" id="EFK57186">
        <property type="protein sequence ID" value="EFK57186"/>
        <property type="gene ID" value="HMPREF0766_12259"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013798_1_1_10"/>
    <dbReference type="OrthoDB" id="1184688at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008756">
        <property type="entry name" value="Peptidase_M56"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05569">
        <property type="entry name" value="Peptidase_M56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M56" evidence="3">
        <location>
            <begin position="139"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="2">
        <location>
            <begin position="336"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="2">
        <location>
            <begin position="466"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="546" mass="61550" checksum="D144D7455BD54708" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMW6</accession>
    <name>D7VMW6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12336"/>
    <dbReference type="EnsemblBacteria" id="EFK57263">
        <property type="protein sequence ID" value="EFK57263"/>
        <property type="gene ID" value="HMPREF0766_12336"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3189160_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="46" mass="5714" checksum="23A3083C90B21E51" modified="2010-10-05" version="1">MTAEERYYFFFENNKELFNQVPLQYIASMLGMRPETFSRIRKKQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN08</accession>
    <name>D7VN08_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15 16">Protoporphyrinogen IX oxidase</fullName>
            <shortName evidence="15">PPO</shortName>
            <ecNumber evidence="15 16">1.3.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HMPREF0766_12378</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16">Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>3 A + protoporphyrinogen IX = 3 AH2 + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:62000"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="15 16">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 15 16">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Cell membrane</location>
            <topology evidence="3 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15 16">Belongs to the HemJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="15 16"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992902.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12378"/>
    <dbReference type="EnsemblBacteria" id="EFK57305">
        <property type="protein sequence ID" value="EFK57305"/>
        <property type="gene ID" value="HMPREF0766_12378"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1981">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125006_0_0_10"/>
    <dbReference type="OrthoDB" id="1433260at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070818">
        <property type="term" value="F:protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02239">
        <property type="entry name" value="HemJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005265">
        <property type="entry name" value="HemJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40255">
        <property type="entry name" value="PTHR40255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03653">
        <property type="entry name" value="UPF0093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004638">
        <property type="entry name" value="UCP004638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15 16" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 15 16" id="KW-0349">Heme</keyword>
    <keyword evidence="13 15 16" id="KW-0408">Iron</keyword>
    <keyword evidence="14 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR004638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFK57305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="177" mass="20572" checksum="CFBCA6E11607FC85" modified="2010-10-05" version="1">MVYLYAKAIHIIFVVCWMAGLFYIVRLFIYHIEAKRKSAGEYTILHKQFVIMESKLWWIITTPAMYLTIAAGALMLYLSPSWLQMGWMHVKLLFVAGLVVYHFICQRIMRQLAAETCTWSSTNLRLWNELATLFLFAIVFTIVLKSAINWIFGVVGLVGLSVVLMMAVKLYKKYRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN57</accession>
    <name>D7VN57_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992967.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12427"/>
    <dbReference type="EnsemblBacteria" id="EFK57354">
        <property type="protein sequence ID" value="EFK57354"/>
        <property type="gene ID" value="HMPREF0766_12427"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2262043_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="103" mass="11193" checksum="91102D20762AB29F" modified="2010-10-05" version="1">MADQENKQGTQPGVPSSSPQGAEDAKLKAEQEAKAKADKDAADAKAKADAKAEKDKKSKKYTVISPFADKDNFGKKWVEGDDVSHFEQDRLDLCVERGLVKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN65</accession>
    <name>D7VN65_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992978.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12435"/>
    <dbReference type="EnsemblBacteria" id="EFK57362">
        <property type="protein sequence ID" value="EFK57362"/>
        <property type="gene ID" value="HMPREF0766_12435"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133639_0_0_10"/>
    <dbReference type="OrthoDB" id="2007530at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="143" mass="15542" checksum="ED15D162B2D7DD4B" modified="2010-10-05" version="1">MEELKKYILASLSCDFGVNGVKTANSVKDLISLLKSSQGIEFCMENSFPSLDILKVYESELLASGVYLQGKYSLENPNLVIAFGGTIGIHLDGYTVCQVYGTNDAQINVFGNDSSIAMVEVHGDANVFVQQLDESSINVFQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VND4</accession>
    <name>D7VND4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993068.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12504"/>
    <dbReference type="EnsemblBacteria" id="EFK57431">
        <property type="protein sequence ID" value="EFK57431"/>
        <property type="gene ID" value="HMPREF0766_12504"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50339XQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2345249_0_0_10"/>
    <dbReference type="OrthoDB" id="2042516at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="104" mass="11599" checksum="D0F61A4129B82FD3" modified="2010-10-05" version="1">MKTYLIFLLIFNSITCTNTRTETNKDIPVNAFADTKSTSDTHAGSASETREDSKDKVYICSSKTAKRYHYKENCRGLSNCGSKIVKTTIDKAKDSGKTLCGWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNE0</accession>
    <name>D7VNE0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RND transporter, HAE1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yegN2</name>
        <name evidence="2" type="ORF">HMPREF0766_12510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993077.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12510"/>
    <dbReference type="EnsemblBacteria" id="EFK57437">
        <property type="protein sequence ID" value="EFK57437"/>
        <property type="gene ID" value="HMPREF0766_12510"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_10"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="856"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="881"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="907"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="956"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1025" mass="113198" checksum="505EE997B37B323C" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNF0</accession>
    <name>D7VNF0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpsB</name>
        <name evidence="8" type="ORF">HMPREF0766_12520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993088.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12520"/>
    <dbReference type="EnsemblBacteria" id="EFK57447">
        <property type="protein sequence ID" value="EFK57447"/>
        <property type="gene ID" value="HMPREF0766_12520"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040318_1_2_10"/>
    <dbReference type="OrthoDB" id="1623045at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="224"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK57447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="270" mass="30029" checksum="A7DC3A552CC8354B" modified="2010-10-05" version="1">MARTTYQDLLDAGVHFGHLTRKWDPKMAKYIFMERNGIHIIDLNKTLTKLEEAASAIKQIVKSGRKVLFVATKKQAKEIIAQQAKEVNMPFVTERWLGGMLTNFATVRKSIKKMSNIDKMQKDGTYDVLSKKEKLMIQRERIKLESLLGGIADLNRLPAALFIIDVKKEHIAVSEAIKLNIPTFAMVDTNSDPTNIDFPIPANDDATKSISLIAGIISKAIQEGLDERKRDKEDEAEKEAAAAKAQVDNGGEAQEANAGAKRPRKAKDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNP0</accession>
    <name>D7VNP0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993207.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12610"/>
    <dbReference type="EnsemblBacteria" id="EFK57537">
        <property type="protein sequence ID" value="EFK57537"/>
        <property type="gene ID" value="HMPREF0766_12610"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178571_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="74" mass="8335" checksum="A44B08451A169946" modified="2010-10-05" version="1">MPVILIPKKLSPGINHIVVTKSKIIQKIIARKTAVNLKTPQAMNVPEIVGLRRATALLIVFLQHPRFLNMFKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP04</accession>
    <name>D7VP04_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993398.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12724"/>
    <dbReference type="EnsemblBacteria" id="EFK57651">
        <property type="protein sequence ID" value="EFK57651"/>
        <property type="gene ID" value="HMPREF0766_12724"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0627">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037618_3_1_10"/>
    <dbReference type="OrthoDB" id="1828423at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107093" evidence="1">
        <location>
            <begin position="19"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="266" mass="30377" checksum="96FB06CC8A205277" modified="2010-10-05" version="1">MKIYFFLLLFLLSGLCFAQETVLISSQSLQTTDSVYVYKPKGYSKKKQYPVVYLLHSHGANYRTFSRILDLQRLSDTYRFLIVCPDGLKSSWFMNSPLKSGIQYEDFFIRELMPYINKHFGGRADASFVTGASMGGHGALWLFVNYPASFLSAGSSSGVVNLRHSGFKKTTIAEHLGEYSDTNENFDRYSVVTNIKRLKGLSKTFIFDCGTEDYLYKANKSLRDSCDQWKIKATYIARPGAHTGTYWSESLPVHFEYFNTLLKTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP79</accession>
    <name>D7VP79_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PF03932 family protein CutC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">cutC</name>
        <name evidence="3" type="ORF">HMPREF0766_12799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993522.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12799"/>
    <dbReference type="EnsemblBacteria" id="EFK57726">
        <property type="protein sequence ID" value="EFK57726"/>
        <property type="gene ID" value="HMPREF0766_12799"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050555_3_2_10"/>
    <dbReference type="OrthoDB" id="1728422at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00795">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="Cu_homeostasis_CutC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="PTHR12598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="SSF110395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="254" mass="27896" checksum="C03F407F686C6808" modified="2010-10-05" version="1">MIGKEKDLNGYKLEICANSITSAIAAEEGGASRVELCQNLENGGTTPSYGQIRITRERLSIGIHVLIRPRGGDFLYSDDEFNEILADVTYCKEIKCDGVVVGILDKEGNVDIPRMQKIIETARPLKVVFHRAFDKCRDPYSSLEDIISLGCDRILTSGQANSAWEGKELLRELIGKAEGRIEIMPGGGVNEDNIAELLSYTQALSAHSSAKEDVASGMLYKDNKVMGMDEGTVLSSTKKVRLMADILKKPLKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP91</accession>
    <name>D7VP91_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993556.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12811"/>
    <dbReference type="EnsemblBacteria" id="EFK57738">
        <property type="protein sequence ID" value="EFK57738"/>
        <property type="gene ID" value="HMPREF0766_12811"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030VAC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1884460_0_0_10"/>
    <dbReference type="OrthoDB" id="2023839at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107403" evidence="1">
        <location>
            <begin position="20"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="135" mass="14624" checksum="1431137CBB473303" modified="2010-10-05" version="1">MKMKAMYLMVVALVMVAFVGCSDKDDPAPSGGSIDAVLGNYKGTIKIIGGAEVFDQTLVITKVNDKKVKVTAQNTSLNLPVRELEVINNMNISIQAVATEPQGSLIYTFENKGLMFVAERTAEGQLEYSFNGTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPL8</accession>
    <name>D7VPL8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993794.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="ESTHER" id="9sphi-d7vpl8">
        <property type="family name" value="Duf_900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57865">
        <property type="protein sequence ID" value="EFK57865"/>
        <property type="gene ID" value="HMPREF0766_12938"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_792029_0_0_10"/>
    <dbReference type="OrthoDB" id="997135at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010297">
        <property type="entry name" value="DUF900_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05990">
        <property type="entry name" value="DUF900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107489" evidence="1">
        <location>
            <begin position="23"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="350" mass="40294" checksum="B3520E64512A5711" modified="2010-10-05" version="1">MNRYIACLVCLFVVTSCGITHNVPLNQTPNSFEKPNISNSFVDQNGNFYPDNWKKSYGAPPENGKKNDYSLMKIATERGEGDKLRSYETQQLKQVAKRLANKKRVFIFVHGFNSDVRTSNQSYDYIRKQLNVNSNQDEVIRFYWDGLVTNNPFSGAKIWFAATSFSQMAGEFGLRRLLNTMHNKNIYIISHSRGASVVLSALSTPVFKEKFVEEVKDIHHVDIDDASSLKENKNNITCIMLAPAVGLADFRPKDYREGDSTYCIFSEQVKKIHITTNNTDKMLKKVFGFLSDKLEPTDLGYKEDVYNVLCKHYPFFEMTDFSGMDSHEFKRYIRNPKFKTILKEHKIGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPP7</accession>
    <name>D7VPP7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12967"/>
    <dbReference type="EnsemblBacteria" id="EFK57894">
        <property type="protein sequence ID" value="EFK57894"/>
        <property type="gene ID" value="HMPREF0766_12967"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_5_2_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="123" mass="14520" checksum="F9A09837A4A68614" modified="2010-10-05" version="1">MEHSQIEHTDCPLQSSRTLMLIKDALDTIQGKWRIRIIAVLLDGPKRFRELSTELETITDRMLSLELKNLEINMLISKKIKSRYRTEMEYELTRHGYTLKPLISELIAWGDLHRSKITEKLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ12</accession>
    <name>D7VQ12_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8 10">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Flavin transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">apbE</name>
        <name evidence="11" type="ORF">HMPREF0766_13066</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Magnesium. Can also use manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the ApbE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="2 8 10"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993985.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13066"/>
    <dbReference type="EnsemblBacteria" id="EFK55863">
        <property type="protein sequence ID" value="EFK55863"/>
        <property type="gene ID" value="HMPREF0766_13066"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044403_0_0_10"/>
    <dbReference type="OrthoDB" id="2021063at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006268">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005968370" description="FAD:protein FMN transferase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006268-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK55863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="346" mass="38632" checksum="DA8911CB6FE8FAA7" modified="2010-10-05" version="1">MKRSWTVLVIFFIGCLGAYAGQPNKISDRHVIDGRAQGTTYHIVYYAEKTIPKSAIDSMLNDIDNSMSVYNKNSLISKFNLPETTSIEMDHHMQKVVNKSFAYYKLSKGQFDITVAPLVQLWGFGPARISALPDEEQIRETLKNVGMNQLKVRGKLLLKKNPKVSIDLNGIAQGYSVDVLADYLLQQGIQNFIVELGGELRINGKKSDGERLKVGIERPVKTNGNTELKQDVIVPPGGAITTAGNFEKFLMDKNRKITHHINPKTGYSFETNIVSVTVHAPTAMEGDALDNIFMAMSPDEAIVFANKIKNIDIYIIYNNQQGDILEKHTKGFENLFDINPIPNLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQB1</accession>
    <name>D7VQB1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-deoxy-manno-octulosonate cytidylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">CMP-2-keto-3-deoxyoctulosonic acid synthase</fullName>
            <shortName evidence="2">CKS</shortName>
            <shortName evidence="2">CMP-KDO synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">kdsB</name>
        <name evidence="3" type="ORF">HMPREF0766_13165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23448"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:85986"/>
            <dbReference type="ChEBI" id="CHEBI:85987"/>
            <dbReference type="EC" id="2.7.7.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KdsB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.38" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994153.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13165"/>
    <dbReference type="EnsemblBacteria" id="EFK55962">
        <property type="protein sequence ID" value="EFK55962"/>
        <property type="gene ID" value="HMPREF0766_13165"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065038_0_1_10"/>
    <dbReference type="OrthoDB" id="1345588at2"/>
    <dbReference type="UniPathway" id="UPA00358">
        <property type="reaction ID" value="UER00476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008690">
        <property type="term" value="F:3-deoxy-manno-octulosonate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033468">
        <property type="term" value="P:CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02517">
        <property type="entry name" value="CMP-KDO-Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00057">
        <property type="entry name" value="KdsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003329">
        <property type="entry name" value="Cytidylyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004528">
        <property type="entry name" value="KdsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02348">
        <property type="entry name" value="CTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00466">
        <property type="entry name" value="kdsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK55962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="246" mass="28022" checksum="BD1B3956CFDBD4EC" modified="2010-10-05" version="1">MKIIGIIPARYASSRFPGKPLIDIAGKSMIQRVYEQVKQTPGLHEVVVATDDIRIEEHVRSFAGNVVMTSDTHESGTDRCAEVISKVSGFDIAINIQGDEPFINPLQIELLISCFENERTQIATLVKEIHTEAELLNVNIPKVVRSASGEAIYFSRQTIPFIRNTEQKNWLTAHQFYKHIGIYGYRKNILQELTKLPVSILEKAESLEQLRWVENGYRIQTAVTTHETIAVDTPQDLEHIMQTYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQL3</accession>
    <name>D7VQL3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heparinase II/III-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13267"/>
    <dbReference type="EnsemblBacteria" id="EFK56064">
        <property type="protein sequence ID" value="EFK56064"/>
        <property type="gene ID" value="HMPREF0766_13267"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_321002_0_0_10"/>
    <dbReference type="OrthoDB" id="442785at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040925">
        <property type="entry name" value="HepII_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18675">
        <property type="entry name" value="HepII_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HepII_C" evidence="1">
        <location>
            <begin position="820"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="910" mass="103817" checksum="37329B010358732F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQN3</accession>
    <name>D7VQN3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13287"/>
    <dbReference type="EnsemblBacteria" id="EFK56084">
        <property type="protein sequence ID" value="EFK56084"/>
        <property type="gene ID" value="HMPREF0766_13287"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075802_2_0_10"/>
    <dbReference type="OrthoDB" id="1740922at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018764">
        <property type="entry name" value="Anti-sigma_K_RskA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10099">
        <property type="entry name" value="RskA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="269" mass="29560" checksum="694A8D1769DC1632" modified="2010-10-05" version="1">MGLASEEEVSILECVRKNNAEVEQAILEAQQTLEEFATVHAMPPPAGLKTAIWDKISAQESTDSDNEKIVPFISQAEENPQPVEQKSEEDPRIKNLDRVQSSRTVSRIAVAASLISVCSLLGNLYLHNKSKENESQLAKVAAENNVNQQALASLQDKWKMVYDPHMKTITLAGVENHPDLKALVFWDSKSKNVYLSMENMPAAPEGMQYQLWAIVDGKPVDAGVFPQDKAADVNMMSTIPSAQAFAITLEKQGGSPTPTMSQMYVMGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQP4</accession>
    <name>D7VQP4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13298"/>
    <dbReference type="EnsemblBacteria" id="EFK56095">
        <property type="protein sequence ID" value="EFK56095"/>
        <property type="gene ID" value="HMPREF0766_13298"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3222230_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="44" mass="5425" checksum="FFEB96654B682E26" modified="2010-10-05" version="1">MDKNDRFKSFLCHIFAALYEEDNWEEGNITSNIEFIFRNQYFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQR0</accession>
    <name>D7VQR0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994437.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13314"/>
    <dbReference type="EnsemblBacteria" id="EFK56111">
        <property type="protein sequence ID" value="EFK56111"/>
        <property type="gene ID" value="HMPREF0766_13314"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3495">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144198_0_0_10"/>
    <dbReference type="OrthoDB" id="1921364at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="166" mass="19110" checksum="8F51E32F54BE3F01" modified="2010-10-05" version="1">MVLHFIIPLLIVFLSISIIQPSEAQQNVQQQHLTDHKALMNKTWEVFDQLMYKVEKRADKTVYIPHFPPALQQLNNKSVSLQGYIVPINTGRKHNWFLLSVLPVAQCMFCGQNGIPPMAEIMMKNKHKITYSELPVHIRGIVYLNADKDGHTEIQIRDAELIINNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQR4</accession>
    <name>D7VQR4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0766_13318</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994442.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13318"/>
    <dbReference type="EnsemblBacteria" id="EFK56115">
        <property type="protein sequence ID" value="EFK56115"/>
        <property type="gene ID" value="HMPREF0766_13318"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_24_0_10"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043906">
        <property type="entry name" value="Gfo/Idh/MocA_OxRdtase_bact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19051">
        <property type="entry name" value="GFO_IDH_MocA_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107159" evidence="6">
        <location>
            <begin position="31"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA" evidence="7">
        <location>
            <begin position="42"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C2" evidence="8">
        <location>
            <begin position="209"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK56115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="443" mass="49705" checksum="3280A4DAD499350D" modified="2010-10-05" version="1">MNTRRQFLKKTSLLAGSGLLASSLPNSVFAMFNNSVMPNEQVNIAVIGAKGMGWSNVNAAMKIPGVNLIGICDVDKNVIDNRLAELNKKNIDTNKIKTYGDYRALLDNKDVDAVIIGTPDHWHALQMIHACEAGKDVYVEKPVGNSIVECNRMVAAQTRYNKVVQAGQWQRSQKHFKDAVDFINTGQLGNIRTVKVWCYQGWMKPGPVVPNSAVPTGVDYKQWLGPAPLVPFNSSRFHFNFRWFWDYAGGLMTDWGVHLLDYALLGMKAELPKSIVGLGGRFAYPDLYEETPDTLTTLYEFDKFNMVWDSAMGIDNGSYNRDHGIAYIGNNGTLILNRGGWEVIEEKKSQNKVVVPFTAASDNGLQNHMQNFIDVIKSRKMEDLKCSIQAGSHVATVAQMGNISYRSGEKLMWNKNNNSFTDSKINKLYLEKEYHNGYKLPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQT1</accession>
    <name>D7VQT1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994461.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13335"/>
    <dbReference type="EnsemblBacteria" id="EFK56132">
        <property type="protein sequence ID" value="EFK56132"/>
        <property type="gene ID" value="HMPREF0766_13335"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180000_0_0_10"/>
    <dbReference type="OrthoDB" id="2056222at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="103" mass="11319" checksum="A000F858B7668475" modified="2010-10-05" version="1">MATDRTLRTCEKGHTFYKSTTCPTCPQCNKKKGTATGFLTYLSNPAKNSLLYHGIDTLEALSAYTRKQILNLHGIGKASIPTLEKLLAGQGLSFRSEQPVQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQY8</accession>
    <name>D7VQY8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13392"/>
    <dbReference type="EnsemblBacteria" id="EFK56189">
        <property type="protein sequence ID" value="EFK56189"/>
        <property type="gene ID" value="HMPREF0766_13392"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3222232_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="44" mass="5497" checksum="3E8CCDEF7B82FDD4" modified="2010-10-05" version="1">MVTTSPFVLSVYLQEGCFLFFITDWFIVVKWYWFLFTYREYPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR33</accession>
    <name>D7VR33_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994600.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56234">
        <property type="protein sequence ID" value="EFK56234"/>
        <property type="gene ID" value="HMPREF0766_13437"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_789135_0_0_10"/>
    <dbReference type="OrthoDB" id="496713at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="351" mass="40442" checksum="B683232E8106A683" modified="2010-10-05" version="1">MKTFLKIIKYTLITILSICLILFFYFFISNKLFLGSKNEDNISYLTKNKSQITDSINSELFDQDFYKSNVFLLGEIHGYADNQKLDKELLFFLNKRLGVRYYIAEMDSLTAKKLTAFLKDSSKNENNLKEVVTAIKKRIPQQSSQELFDKWSDIYDYNQKLADSLKITVIGIDKGFDDASKVSRDSVMFVNFKNAVKEMKLENEKFYGLFGFFHALQNKVQGGNETFASELKKSGIKVSSFVSYTLDSEMYLPKNAQFPTPKDEKIDWVNADGPLQLVKGINDLKDLSSPNTITLFRINAQHSPYFKSQNLITVKSRVFGENIVPEKDSFATDYFQYIFLLRNAKALTKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR44</accession>
    <name>D7VR44_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="7">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="7">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fabH</name>
        <name evidence="10" type="synonym">fabHA</name>
        <name evidence="10" type="ORF">HMPREF0766_13448</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994611.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13448"/>
    <dbReference type="EnsemblBacteria" id="EFK56245">
        <property type="protein sequence ID" value="EFK56245"/>
        <property type="gene ID" value="HMPREF0766_13448"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039592_3_1_10"/>
    <dbReference type="OrthoDB" id="872193at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="9">
        <location>
            <begin position="114"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="8">
        <location>
            <begin position="243"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="7">
        <location>
            <begin position="260"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK56245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="332" mass="36712" checksum="34611CBE45D8E9F9" modified="2010-10-05" version="1">MNNSLPTRLFASITAIGGYVPQNRRTNYDLEKVCNTSDEWIVKRTGIKERRILEENLATSDMAVRAIHDLVEKFNKNIYDVDAILVATSTPDMPMPATANIIAEKLGLANIWAFDINAACSGFLYALDMGASLIETNRYKNILVIGADNISTFVNVEDRSTNILFGDGAGVVWLEPSTVGGIMDAYLRSNGTGREFLNIEAGGSLYPHKNEPTESERKYLKQDGKTVFKQAVQSMSDACNNVLQKNNLTIDDVRWLVPHQANQRIIDAVGRSINIAEGKTLSNIEYLGNTIAATIPLCIWENLKQINRGDLVMLTAFGAGFSWGASLLRWMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR49</accession>
    <name>D7VR49_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6265 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994617.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13453"/>
    <dbReference type="EnsemblBacteria" id="EFK56250">
        <property type="protein sequence ID" value="EFK56250"/>
        <property type="gene ID" value="HMPREF0766_13453"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_972163_0_0_10"/>
    <dbReference type="OrthoDB" id="1708897at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046232">
        <property type="entry name" value="DUF6265"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19780">
        <property type="entry name" value="DUF6265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6265" evidence="1">
        <location>
            <begin position="25"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="286" mass="32533" checksum="995C954963B012A1" modified="2010-10-05" version="1">MKAILALILWSVLVPAFGQSLLPVFLKGTWKVNNAEIYEHWDQLNDKTLKGFSYRIKNGQINVTEYLNLTQSKDRIVYTATVVNQNLGKPVPFTMKEKEGAFIFENLKHDFPKQIIYKKISDMEIEVQISDLKQKEHRFNMRKLSSNTQQDTATSNSNYDALLAEKLGGDAYGMKKYILVILKTGTNNTTDKTFINESFSGHLQNINRLVEQGKLIVAGPLGKNQNNYRGIFILNNINTLEEAKEILQTDPAVKAGLLDIELFNWYGSAALPEYLPASDKIWKQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR91</accession>
    <name>D7VR91_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_13495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994671.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13495"/>
    <dbReference type="EnsemblBacteria" id="EFK56292">
        <property type="protein sequence ID" value="EFK56292"/>
        <property type="gene ID" value="HMPREF0766_13495"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010756_0_0_10"/>
    <dbReference type="OrthoDB" id="1034540at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="40"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="972" mass="108326" checksum="4A98F22FC57601BD" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRE5</accession>
    <name>D7VRE5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, AAA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994736.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13549"/>
    <dbReference type="EnsemblBacteria" id="EFK56346">
        <property type="protein sequence ID" value="EFK56346"/>
        <property type="gene ID" value="HMPREF0766_13549"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_25_0_10"/>
    <dbReference type="OrthoDB" id="1115436at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="49"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="240" mass="27418" checksum="2085280400B463E0" modified="2010-10-05" version="1">MNIYDLLINDKEKVSLADIFLEDSSKQSFVQLIKEHTYIEELHTYGLPVNNKILLHGSSGCGKTMTAKAIAKELDKNILILNLSNIVCSRIGETSQNIKQVFDKAGREKAVLFLDEFDQIGKARGNDDKDVGEMRRLVNTLIQLIDYYPENALLLCATNHAEIIDTALLRRFQLRVNFEMPSKKVLDTYYDKLLAAFPEDLQYIDRKYNISFAEAKDHTFTLVKAKLIRELEAGKKSVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRJ4</accession>
    <name>D7VRJ4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mg2+ transporter-C family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mgtC</name>
        <name evidence="8" type="ORF">HMPREF0766_13598</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MgtC/SapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994797.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13598"/>
    <dbReference type="EnsemblBacteria" id="EFK56395">
        <property type="protein sequence ID" value="EFK56395"/>
        <property type="gene ID" value="HMPREF0766_13598"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079292_0_0_10"/>
    <dbReference type="OrthoDB" id="2022224at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK56395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="214" mass="23958" checksum="2A3AC3D10884FF7A" modified="2010-10-05" version="1">MFGDFFQDERVQAVFVSILCGCVIGFEREYRNKSAGFRTVVLICFGSTIFTMVSMLGEQSDDRIAANIVTGIGFLGAGVIFKGKMSVLGLTTAAVIWSMAAIGMVIGTGEFVLAFFLTGCMFVILAFFHKIERMLSGFFFTKTLYITFQDIGLYHLKDFEELLLDGSVKPVRKGLEKRGNQLMVIYDITGRRKHIQAVNEKIVGLDYVYEFSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRL6</accession>
    <name>D7VRL6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5'-nucleotidase, C-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994839.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13620"/>
    <dbReference type="EnsemblBacteria" id="EFK56417">
        <property type="protein sequence ID" value="EFK56417"/>
        <property type="gene ID" value="HMPREF0766_13620"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094493_0_0_10"/>
    <dbReference type="OrthoDB" id="1884225at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5_nucleotid_C" evidence="1">
        <location>
            <begin position="30"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="214" mass="23459" checksum="4FA08D19725AC21B" modified="2010-10-05" version="1">MNNTIAADSAVIALYAPYKQQMESEMNRVIGYSDTYLTKTRDAESLIGNFFADALLDIGKTLDKDAVFSFATKGGIRTDMRQGDITVGKIFEIMPFENKISILELSGKDVLTLADFIAQTGGQPIGGMRMEIVGKKATSVKINGQDIDPAKHYKMVTYDYIANGGDNLDALASPVSRKDYESKVREGLMDYIGRQTKAGKHINAVLDGRVKISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRQ1</accession>
    <name>D7VRQ1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994932.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13655"/>
    <dbReference type="EnsemblBacteria" id="EFK56452">
        <property type="protein sequence ID" value="EFK56452"/>
        <property type="gene ID" value="HMPREF0766_13655"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1359676_0_0_10"/>
    <dbReference type="OrthoDB" id="2066422at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107304" evidence="1">
        <location>
            <begin position="19"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="201" mass="21494" checksum="A4AD9B6666228264" modified="2010-10-05" version="1">MTTVKSFFKTALAIAALATLTVSCNKDNEKVTPLELNKAQANSSLYVIDGQWWSPMNAANWPNIYVDLSGSGDQSTNASDIHQVIFGSHVNGNISAGSGYAIKFIDKDYSTVVASDWNSSSAISATTLGRQTTTTPPYGWYTYNTTTRANEAIAGRTILVRSDDGSEIYAVKLIEFTNVSQTGSGAGLQVKADANIAFKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRX9</accession>
    <name>D7VRX9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tat pathway signal sequence domain protein</fullName>
            <ecNumber evidence="4">4.1.2.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13733</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.5" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995137.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13733"/>
    <dbReference type="EnsemblBacteria" id="EFK56530">
        <property type="protein sequence ID" value="EFK56530"/>
        <property type="gene ID" value="HMPREF0766_13733"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029381_0_4_10"/>
    <dbReference type="OrthoDB" id="1124266at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004793">
        <property type="term" value="F:threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="3">
        <location>
            <begin position="68"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="398" mass="44256" checksum="37FAD7C9E2477876" modified="2010-10-05" version="1">MSSFKRRDFLKLSGLALPAIAQIVPSTSFADSASKDKILNDSDAVYFINDGIFYKPDDFIAQLQAIQAKDPIERDSYATDGTMKKLLDKCIKITGKEAAIYMPSGTLANQLAISVLGKSATKAFVQEKSHVYRDEGDAAQTLFNKRLIPLATDNHWFDQKELQQAVDVHEQGEAFAVPGAVVSIETPVRRADNRVFPLEEIKKIAEYCNLKGYRMHLDGARLHVASAYTGHAIADYAQYFDTVYLCLYKYLGATGGAVLCGDKVVIDQMHHLVKIHGGGVFTNWPNAAMALHHLEDIDRVMQEVKDKSQTLFNLFNRMDDIQVEHPEHGSNISLMKIGKGIDSVKLRGHLRHEHNIILGQPRQADGMIAVKTNATLLRRANSQLVSAFEDAIRMAKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS24</accession>
    <name>D7VS24_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56575">
        <property type="protein sequence ID" value="EFK56575"/>
        <property type="gene ID" value="HMPREF0766_13778"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3122806_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="50" mass="5709" checksum="30E56CCFA3102CE8" modified="2010-10-05" version="1">MESGIIYECILFTVLFGEVVVNTKSKLEIRSNGIILEKLLKPYQITSFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS58</accession>
    <name>D7VS58_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ycnE</name>
        <name evidence="2" type="ORF">HMPREF0766_13812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995322.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13812"/>
    <dbReference type="EnsemblBacteria" id="EFK56609">
        <property type="protein sequence ID" value="EFK56609"/>
        <property type="gene ID" value="HMPREF0766_13812"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131496_11_1_10"/>
    <dbReference type="OrthoDB" id="1909149at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="96" mass="11486" checksum="2AE1EC452B089144" modified="2010-10-05" version="1">MNIYLTAVIKAKSEYRDEVLEILKNMVSRTLQEPACQKYDLHEDLEDPNWFVFYEIWQDQQGLDVHNQQSYIRDFVAVVPEKLQEAPLIIRMKKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS68</accession>
    <name>D7VS68_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
            <ecNumber evidence="1">1.1.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gdhII</name>
        <name evidence="1" type="ORF">HMPREF0766_13822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995352.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13822"/>
    <dbReference type="EnsemblBacteria" id="EFK56619">
        <property type="protein sequence ID" value="EFK56619"/>
        <property type="gene ID" value="HMPREF0766_13822"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_10"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047936">
        <property type="term" value="F:glucose 1-dehydrogenase [NAD(P)] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="250" mass="26061" checksum="E89F52B3578CC0C2" modified="2010-10-05" version="1">MGILDNKVAIVTGAGSGIGRAVALSYGKEGAKVVVSDINEKAGQETVDTVVRAGGTAFFFKADTSSAEENEALVEATIEKYGKLDIACNNAGIGGAAALSGDYGLEDWKKVTDINFNGVFYGCKYQLKAMEKNGGGAIVNMASIHGMVAAPMSSAYTASKHAVVGLTRNIGAEYGPKNIRCNAVGPGYIMTPLLTTHLGKEQLEALRAKHPMGRLGDAEEVAELVLFLSSDKASFMTGGYYLIDGGYTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS92</accession>
    <name>D7VS92_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6268 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995420.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13846"/>
    <dbReference type="EnsemblBacteria" id="EFK56643">
        <property type="protein sequence ID" value="EFK56643"/>
        <property type="gene ID" value="HMPREF0766_13846"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZA7A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069817_0_0_10"/>
    <dbReference type="OrthoDB" id="1238966at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046235">
        <property type="entry name" value="DUF6268"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19783">
        <property type="entry name" value="DUF6268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6268" evidence="1">
        <location>
            <begin position="39"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="319" mass="36552" checksum="8632E2F814F7F809" modified="2010-10-05" version="1">MNTVLAQSADSVAREAQITKLTLAYAALKFKELRPFNAEYSYLTPYNYSAQIAAENLPDRKMTNFSQAMVGVNLNLIKKQKWALGTTLGYRYIMTESEPTYTSGADKSTQRNDYQAHYTSVNLAYFTRFFNKMTIFSSSVAVDGSEKDFERVRGLITGTMILKANRQTRMAIGLLWNIDPSALIPIIPTFLYEHEFDNGFIADINLPRNLMLRKHVFRKGRVSMGAELDGNSFYLYNIDGTSQKYQYSQMDINSGFVYEHLLGNYFIIAAKTGVRIVPTARVFEKEKSFEDYIYKIKPDPAFYFNIGLSFNPFSKIKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSE2</accession>
    <name>D7VSE2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995524.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13896"/>
    <dbReference type="EnsemblBacteria" id="EFK56693">
        <property type="protein sequence ID" value="EFK56693"/>
        <property type="gene ID" value="HMPREF0766_13896"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9R9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_559993_0_0_10"/>
    <dbReference type="OrthoDB" id="274403at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107528" evidence="2">
        <location>
            <begin position="18"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="494" mass="57644" checksum="55CC7C3C205874E0" modified="2010-10-05" version="1">MKITVLYILFMLTSVTACTQEIKDNSSLVSTKMKTIHTVPYLTREDNFIYVDKTSLKPVIEQKFKTASLFTPTGFAIVGNEKGESSIIDETGKIVLHYSADEINIDVINGLTFYKKEIEYEKKMPVWKWDWNIMGSGVKKEQTYHKVEIGVLETKQVLLSEDVPYLEDEYSLNFVSVDENHVFWNRSLYEIKKGRLNKIENNITELLEDKRFIKASNATFSVYELNQKKAIYNSLKGTEALSFRFGNETITLKEVNKERFEPEVPKLLSNSKTNDVYVFPQYEKAFPKQITKATASQINFIKKTSLVYSITNSPYFLLGVFNYDNDVWAYDWLYIDTKGNVADTIDPYNFKVLDQVGYLVWPDRKMILPNQFNKKNWKFGKISYYQGMNDLYLIRIEDEKEVRTMGLWNSKTKAWEIKPEHNDISVLDTEKEIYALQKEKDGLYTLYDNKNKKNIGSNAYKSINSDGLVNAKLHEGETIYYYIDIYSGREYKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSF6</accession>
    <name>D7VSF6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995553.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13910"/>
    <dbReference type="EnsemblBacteria" id="EFK56707">
        <property type="protein sequence ID" value="EFK56707"/>
        <property type="gene ID" value="HMPREF0766_13910"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042641_0_0_10"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="119"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="498" mass="55471" checksum="FC7B429C36C7A91A" modified="2010-10-05" version="1">MKTYLKLGLAIFIIYFYCTGCSEELIEKTVTATVKGMVVKFKTNEPLANVKITSSPTTQTVFSASDGTFEIKGMPLGDYAIKAELNGYVTEIKGANLTNADQSVSLVFEMKDDKSLNSPPTVPQLISPADNAINLPLSVKLTWNCTDPDEDSLSYRLIIKNNKSGDIRDIKNIKDKSYQLENLEYGTSYFWQVVASDSIHAEVFSPSYKLTTSETPQNRFHYVRKSGDNYLIVSSDENNQSFNLTSNQTNSLRVRKSNVAGVLAFIRVTDGNAHIFTTKADGSALSRVTTIPIAGFNITELDFAWSANGKEIVYPNFDKLYRVNKDGSGTEMIYRTPDGSFISECDWSNDGSKIALKTNDIDGYKTKIYVIDILGNVQHSILENVKGAAGGINFSVSGDKILYTHDISGYESQDYRQLKSHIFLYNLVDNTKTDLSAFTKIPAGYNDLDARFSPNEAEVIFTQTSNDGISQKDIYKIAITNETSRKLLFTNAWMPDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSL4</accession>
    <name>D7VSL4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13968"/>
    <dbReference type="EnsemblBacteria" id="EFK56765">
        <property type="protein sequence ID" value="EFK56765"/>
        <property type="gene ID" value="HMPREF0766_13968"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033KDA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1894862_0_0_10"/>
    <dbReference type="OrthoDB" id="1691219at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107249" evidence="1">
        <location>
            <begin position="20"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="122" mass="14340" checksum="26B60764BF7745A5" modified="2010-10-05" version="1">MFKRLFGFLMLFFYMNAIAYHETCILDKIDNDIHSGVTLVNIILDELLDLPANNEQETSDFQYDEYRTANQANAILPILLIVFYLPRVLKTDTLRAPISKRINKAIPLQLGYYQYLFRLKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSM9</accession>
    <name>D7VSM9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH-quinone oxidoreductase subunit D</fullName>
            <ecNumber evidence="2">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">NADH dehydrogenase I subunit D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">NDH-1 subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ndhD</name>
        <name evidence="2" type="synonym">nuoD</name>
        <name evidence="4" type="ORF">HMPREF0766_13983</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995658.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13983"/>
    <dbReference type="EnsemblBacteria" id="EFK56780">
        <property type="protein sequence ID" value="EFK56780"/>
        <property type="gene ID" value="HMPREF0766_13983"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_1_2_10"/>
    <dbReference type="OrthoDB" id="473681at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 2" id="KW-0874">Quinone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="3">
        <location>
            <begin position="140"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="398" mass="45440" checksum="0D88915A82A979D8" modified="2010-10-05" version="1">MTNEVYNQAFTNYQNRIAAIGSQEMVINMGPQHPSTHGVLRLELITDGEIVKDIIPHLGYLHRCFDKHAESVNYTKTIPFTDRLDYLASMNNSHAYVMGVERMLGLDSRIPKRVEYIRVLVCELNRIASHLIAIGTYGIDIGAFTPFMWCFRDREHIMNMLEWASGSRMLYNYIWIGGLFYDLPVGFEERCAEFVNYFKPKLVELDELLTQNQIFISRTANIGALPADVAINYGCSGPMLRASGIKWDLRRVDGYSVYPELEFDIPVGKGEMGQLGDCWDRYKVRVDEIKESVRIVEQCLERLQKDFQRTTDFDPRALVPKKVNIKAQDYYVRAENPKGELGFYFVAQDKTDIPKRVKSRGPSFNNLSVLPELGKGVLIADLIAILGSIDIVLGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSQ1</accession>
    <name>D7VSQ1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative N-carbamoylputrescine amidase</fullName>
            <ecNumber evidence="2">3.5.1.53</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cpa</name>
        <name evidence="2" type="ORF">HMPREF0766_14005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.53" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14005"/>
    <dbReference type="EnsemblBacteria" id="EFK56802">
        <property type="protein sequence ID" value="EFK56802"/>
        <property type="gene ID" value="HMPREF0766_14005"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_4_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050126">
        <property type="term" value="F:N-carbamoylputrescine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="300" mass="34019" checksum="4E3047AB7016EFC7" modified="2010-10-05" version="1">MFNNFDKLEMSKVKVGIVQMSCEKDKQANLDKAIVKVREAAAKGAQIVCLQELFTSLYFCDVEDYDNFDLAESIPGPSTDALAAVAKELGVVIIASLFEKRTQGLYHNTTAILDADGSYLGKYRKMHIPDDPAFYEKFYFTPGDLGYKVFSTKFGKIGILICWDQWYPEASRITALMGAEILFYPTAIGWATDQDEETNTDQYNAWQTIQRSHAVANGVPVVSVNRVGFEQDGAMKFWGGSFAANAQGKLLYLASHDQEEVEVVELDLNQSDYFRKHWPFLRDRRIDSYQPITKRFIDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSR8</accession>
    <name>D7VSR8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, DeoR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">agaR2</name>
        <name evidence="5" type="ORF">HMPREF0766_14022</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995744.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14022"/>
    <dbReference type="EnsemblBacteria" id="EFK56819">
        <property type="protein sequence ID" value="EFK56819"/>
        <property type="gene ID" value="HMPREF0766_14022"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060699_3_1_10"/>
    <dbReference type="OrthoDB" id="1629121at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="261" mass="29061" checksum="CDB77BD584251FED" modified="2010-10-05" version="1">MKFELKPIMNSVERHHLILEKLKQVGNITVSELCEELGVSTVTIRKDLKFLEDSSLLFRVHGGATRQNPYTTDRPVFEKEKLHTLEKSKIGKTAASFVEPNDSIIIASGTTMQAMAKEIEPQGLLTVVTSALNVAQQLIQHQNVEIIQLGGTMRKTSMSVTGAYAEMILKDFFCSKLFLGVDGIDLDFGITTTNAQEARLNRVMMESAQKVIVLVDSSKFGRKSFGKIAEINQIDILITDNYVNPRYVEKLESLGIKVIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSV9</accession>
    <name>D7VSV9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="4">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="4">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">truB</name>
        <name evidence="7" type="ORF">HMPREF0766_14063</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995850.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14063"/>
    <dbReference type="EnsemblBacteria" id="EFK56860">
        <property type="protein sequence ID" value="EFK56860"/>
        <property type="gene ID" value="HMPREF0766_14063"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0130">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_2_0_10"/>
    <dbReference type="OrthoDB" id="1166299at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="5">
        <location>
            <begin position="47"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C_2" evidence="6">
        <location>
            <begin position="189"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="236" mass="26664" checksum="7EC01AE4FE245319" modified="2010-10-05" version="1">MQDHITENFQTFHFAEGQMLLIDKPLTWTSFDVVGKIRNTLKPLKLKVGHAGTLDPLATGLLIVCTGKMTKQIDSFQAEDKEYTGIITLGATTPSYDLETEIDQRFDISGITEEMIFDTARSFEGEINQFPPAHSAIKINGERVYEKARRGEEVELKSRKVTINSFAIEKIELPHVSFRISCSKGTYIRSIANDFGKLLNNGSHLSELRRTKSGNYHVDNAWNLENLIEVIKSQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT21</accession>
    <name>D7VT21_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995976.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14125"/>
    <dbReference type="EnsemblBacteria" id="EFK56922">
        <property type="protein sequence ID" value="EFK56922"/>
        <property type="gene ID" value="HMPREF0766_14125"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZH4T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1718645_0_0_10"/>
    <dbReference type="OrthoDB" id="1444358at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="145" mass="16917" checksum="A386E3AC3A52DD1D" modified="2010-10-05" version="1">MKLSDKATAHILVKANTNSEWDNCEFAIIHLSEEWKQEQAKRLALVKPLEGNHYFCSMNYYDTAVDFYCTGEDDTPNIEEMLNDKEWAFVELDEGEQEMFTAPENRLDCYRLVLRANGTGYYTAYGKHTSEEFWTEEFSLIQLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT79</accession>
    <name>D7VT79_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpoE4</name>
        <name evidence="4" type="ORF">HMPREF0766_14183</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996105.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14183"/>
    <dbReference type="EnsemblBacteria" id="EFK56980">
        <property type="protein sequence ID" value="EFK56980"/>
        <property type="gene ID" value="HMPREF0766_14183"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_4_1_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014327">
        <property type="entry name" value="RNA_pol_sigma70_bacteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02985">
        <property type="entry name" value="Sig70_bacteroi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="25"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="126"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="202" mass="23549" checksum="11FB1B1E6F5C7329" modified="2010-10-05" version="1">MYPLQHEEEFVKHLSEGSQNAYELLFSRYWTHVFAVVRLLVKSQEQAEDITQEIFVKVWNRREDLGEVKNIKAYLYTIARNTTLDHLRKKVLVTENLEQMIHYFTDHALTPVQRIEYKELEDIISKGIATLPSKVKEVFVMSRIDGLSHEEIAARLDISVTSSKTYVVRALKLLRLYMSKNTDLQVLVLAALLLEKIISQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTD4</accession>
    <name>D7VTD4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14238"/>
    <dbReference type="EnsemblBacteria" id="EFK57035">
        <property type="protein sequence ID" value="EFK57035"/>
        <property type="gene ID" value="HMPREF0766_14238"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2920436_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="61" mass="6986" checksum="7703A0FB9F90494C" modified="2010-10-05" version="1">MSVSFIDVFQVFKHLETADKMHLVSLIPPNRFDLQKRSVSLHLDSALSKILLPKISQIQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTE3</accession>
    <name>D7VTE3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14247"/>
    <dbReference type="EnsemblBacteria" id="EFK57044">
        <property type="protein sequence ID" value="EFK57044"/>
        <property type="gene ID" value="HMPREF0766_14247"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3157940_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="48" mass="5498" checksum="8F6D616B324D0EA0" modified="2010-10-05" version="1">MKNVILLFVINIVVVIGFFAALSMKTPWVGFAIAFSVWFIYLWKSTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTN8</accession>
    <name>D7VTN8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14358"/>
    <dbReference type="EnsemblBacteria" id="EFK55797">
        <property type="protein sequence ID" value="EFK55797"/>
        <property type="gene ID" value="HMPREF0766_14358"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_0_2_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="168"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK55797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="354" mass="40453" checksum="69A2137822D0A185" modified="2010-10-05" version="1">MQVNNTDMKAFLKSLLLGIVISAGISLLFSAYYLITYGNLDIQFYKSRGAQIGMIYGVMGYMLNSNLAAYIHSKVPDDNHWRKRLSYFIPGSILVTVLMVFVVNCFFQVIFGKLSFSEFLLRQHLGTYIMTTLIALVVGLGFYAFYFYKAYKNAQIQKQKQIAGNATAQFESLKNQIDPHFLFNSLNVLTGLIEESPEKAVDFTTSLSRIYRYVLEQKDKELVPAQQELKFAQIFLNLLRLRFEEALVVEIDDSYIEEEENIIPLSLQLLIENAIKHNVVSTVRKLHIRIVKKDKYLYVSNNLQPKETLGESTGIGLSNIINRYHLLTTEEVIIKDQNGNFEVGLPLLAIKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTZ0</accession>
    <name>D7VTZ0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14460"/>
    <dbReference type="EnsemblBacteria" id="EFK55769">
        <property type="protein sequence ID" value="EFK55769"/>
        <property type="gene ID" value="HMPREF0766_14460"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2939440_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="60" mass="6002" checksum="E97FD853890EF0E2" modified="2010-10-05" version="1">MDDVIRIGASAGAAIGVWSGGVGEVPRALIGGGSGVIGGFIGGYYGSEWAVQVVNHYHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGG0</accession>
    <name>D7VGG0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002015.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10079"/>
    <dbReference type="EnsemblBacteria" id="EFK60135">
        <property type="protein sequence ID" value="EFK60135"/>
        <property type="gene ID" value="HMPREF0766_10079"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104987_0_0_10"/>
    <dbReference type="OrthoDB" id="1623547at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="96"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="187" mass="21810" checksum="9EE12426B57ECBE6" modified="2010-10-05" version="1">MKTHFDIEKLVESGAITSELDYERALIADRNLRLLAKDNDHFKKLRFRLRDLIEQYENTEWNNADQIDEDKIRESDKAERLAEIERIFIRNRKEAIRDTLKRLTLTQQDLATLLGHKSKTHMSELINGIKPFTLTDLVIINRILKIDITLLVPTFLSFKDQVKVKAAVTKIDKPQLKLAIDDLVVCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGM0</accession>
    <name>D7VGM0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_10139</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996685.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10139"/>
    <dbReference type="EnsemblBacteria" id="EFK59222">
        <property type="protein sequence ID" value="EFK59222"/>
        <property type="gene ID" value="HMPREF0766_10139"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_0_3_10"/>
    <dbReference type="OrthoDB" id="113583at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="61"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="267"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="589" mass="66114" checksum="DA14598A824A5E07" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGQ4</accession>
    <name>D7VGQ4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacteroidetes fimbrillin superfamily. FimB/Mfa2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10173"/>
    <dbReference type="EnsemblBacteria" id="EFK59256">
        <property type="protein sequence ID" value="EFK59256"/>
        <property type="gene ID" value="HMPREF0766_10173"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059697_0_0_10"/>
    <dbReference type="OrthoDB" id="1592124at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014941">
        <property type="entry name" value="FimB/Mfa2/Mfa3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08842">
        <property type="entry name" value="Mfa2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="317" mass="35843" checksum="66ABD53E3D5A180A" modified="2010-10-05" version="1">MQPDSMIQTEMIKRYLKRIYIQLLMIAMLVAINGCIKDDLTRYTFDITLSFTDRAGSCPDKTVYTGTTAMTVYAFDENGYFAAQVSQKDIDFSPESTMKITLPQGNYTLVAWAGTAQGQFEDRLLIKGETHIDELDMPTFTRSSGLRAMPDQVLFQGVLKNINAETAAYTPAQRIDLKNITKPLYVSLEKYDTLKNYQIRISHNAALCQFQTAEMRDAGDHYTVTELQEQKESATYTAQTALLWRLEDRNPIITIRDMETGADIFSASVKELLEKLPQLNLNCEPAVDLKIIRKFPTQAEITVIINGWILVESEGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGS8</accession>
    <name>D7VGS8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sua5/YciO/YrdC/YwlC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yciO</name>
        <name evidence="2" type="ORF">HMPREF0766_10197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996838.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10197"/>
    <dbReference type="EnsemblBacteria" id="EFK59280">
        <property type="protein sequence ID" value="EFK59280"/>
        <property type="gene ID" value="HMPREF0766_10197"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_3_0_10"/>
    <dbReference type="OrthoDB" id="1913202at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="206" mass="23055" checksum="D743B136BBABE415" modified="2010-10-05" version="1">MLIRIYENNPNEKAIQQVVDVLKRGGVIIYPTDTVYGIGCDITNHKAIERVCEIRGMKVDKANLSFICYDLTDISQYTKPFDTSVFRVLKKALPGPFTFIFNASGQVPKLLSSKKKTVGIRVPDNHIVREIVRVLGNPIVTASIRDEDDILEYSTDPELIHEKYENMVDLVIDGGYGDNVASTVVDLTGGDFEIVREGKGDLEQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGS9</accession>
    <name>D7VGS9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996847.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10198"/>
    <dbReference type="EnsemblBacteria" id="EFK59281">
        <property type="protein sequence ID" value="EFK59281"/>
        <property type="gene ID" value="HMPREF0766_10198"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160523_0_0_10"/>
    <dbReference type="OrthoDB" id="1918294at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007922">
        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05258">
        <property type="entry name" value="DciA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="104" mass="12291" checksum="5A6799C0868131BB" modified="2010-10-05" version="1">MYKKKVDEIHSNDDIGIKQAIEKWVDTYRLRRKFDESSIVNAWPEIIGKAIANRTQKIYIKDRKMYVKVESAVIKNELALMRRQIIGRLNEYVGQVVIEELIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGT9</accession>
    <name>D7VGT9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative deoxyhypusine synthase</fullName>
            <ecNumber evidence="2">2.5.1.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996875.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10208"/>
    <dbReference type="EnsemblBacteria" id="EFK59291">
        <property type="protein sequence ID" value="EFK59291"/>
        <property type="gene ID" value="HMPREF0766_10208"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1899">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057081_0_0_10"/>
    <dbReference type="OrthoDB" id="589228at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008612">
        <property type="term" value="P:peptidyl-lysine modification to peptidyl-hypusine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="PTHR11703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="326" mass="36493" checksum="B1753DB14006A502" modified="2010-10-05" version="1">MSTQKGPISQFLEKNYLHFNAAALVDAAKGYEAHLNEGGKMLISLGGAMSTAELGISLAEMIRQDKVAIISCTGANLEEDVMNLVAHSHYKRVPNYRDLTPEQERELLDNHYNRVTDTCIPEEEAFRRLQKHLEDVWHAAEAKGERYLPHEFLYQVVNSGVLEQYYEIDPKNSWIVAAAEKNLPIICPGWEDSTTGNIFAANVIKGNLKASTVKSGIEYMIYLTEWYRENSSGKGVGFFQIAGGISGDFPICVVPMMYQDLEWEDVPFWSYFCQISDSTTSYGSYSGAVPNEKITWGKLDIDTPKFVIESDATIVAPLVFAYVLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGW1</accession>
    <name>D7VGW1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fic family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_10230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10230"/>
    <dbReference type="EnsemblBacteria" id="EFK59313">
        <property type="protein sequence ID" value="EFK59313"/>
        <property type="gene ID" value="HMPREF0766_10230"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040460_2_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="4">
        <location>
            <begin position="194"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="278"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="310"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for autoinhibition of adenylyltransferase activity" evidence="3">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="347" mass="40389" checksum="6FAA15D049CD9B6A" modified="2010-10-05" version="1">MIDAETYSLNFIKFTNESRYSKIFLPANNSKIKAIIYCIFAGNGKYTINSMNYISVREFAKRWNIPERTARNYCATGKIKGAFLTGKTWNIPEDSLLPEKGNKKKFSDNVLLNHFKEQKEMKLKGGIYHRTQIDLTYNSNRIEGSKLTHDQTRYIFETNTIGASKEVINIDDIIETTNHFRCIDLIIDKAKSKLTESFIKELHFLLKSGTSYSRKDWFNVGEYKKLPNEVGGNETCPPKAVSTEMSALLSDYHSIAKKTLEDIIDFHYKFEIIHPFQDGNGRVGRLIMFKECLANNIVPFIIDEDLKLFYYRGLQEWRHIKEYLLDTCLTAQDNYKAILVYFEIEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGW6</accession>
    <name>D7VGW6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">YeeE/YedE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0766_10235</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996949.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10235"/>
    <dbReference type="EnsemblBacteria" id="EFK59318">
        <property type="protein sequence ID" value="EFK59318"/>
        <property type="gene ID" value="HMPREF0766_10235"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037802_3_0_10"/>
    <dbReference type="OrthoDB" id="1518604at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="29"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="137" mass="15488" checksum="91B35021017AB223" modified="2010-10-05" version="1">MRKLVFILIGLILGLTMYKAEAASWFRIYEMFNFQSFHMYGFIGSALIIGIGAIQWIKRRKIKDMDRHQIQITPKEKTFSRYLFGGIIFGLGWALAGACPLPMFVLVGAGVFPILIVILGAVAGTWLYGLIRHKLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGW7</accession>
    <name>D7VGW7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">YeeE/YedE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0766_10236</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996952.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10236"/>
    <dbReference type="EnsemblBacteria" id="EFK59319">
        <property type="protein sequence ID" value="EFK59319"/>
        <property type="gene ID" value="HMPREF0766_10236"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1452982_0_0_10"/>
    <dbReference type="OrthoDB" id="1899767at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="119"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="183" mass="19548" checksum="210021F73AE2E9FC" modified="2010-10-05" version="1">MEWIFEPWPWYIGGPLVAFCMIALLLAGKNFGVSSNFRTICAACGAGKTSDFFKFDWKAQRWNLLILIGAVLGGYVGAHILSDGAQIPAIHPDTITKLHELGFQSAGKAYAPAELYDTLDLRTLALLLTGGLLVGFGSRYAGGCTSGHAISGLSDLQLPSLIAVVGFFIGGLLMVHVIFPVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGX9</accession>
    <name>D7VGX9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996984.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10248"/>
    <dbReference type="EnsemblBacteria" id="EFK59331">
        <property type="protein sequence ID" value="EFK59331"/>
        <property type="gene ID" value="HMPREF0766_10248"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104065_0_0_10"/>
    <dbReference type="OrthoDB" id="1623896at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007352">
        <property type="entry name" value="DUF420"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37692">
        <property type="entry name" value="PTHR37692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04238">
        <property type="entry name" value="DUF420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="181" mass="20342" checksum="099BC39C89A40B57" modified="2010-10-05" version="1">MGQQTLEEKKYNKWIVILSVTIPVVVAILFGVNLRKLGYDVQPLSFLPPIYAAINGLTAILLVWAVAAIKRGNKALHERLIKVCIACSVAFLAMYVAYHMTSDSTPYGGEGAMRYIYFVILISHILLSIIIIPFVLVTFVRGIAGAYERHKKLARITYPMWLYVAVTGVIVYLMISPYYTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGY4</accession>
    <name>D7VGY4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="8">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cyoE</name>
        <name evidence="8" type="synonym">ctaB</name>
        <name evidence="9" type="ORF">HMPREF0766_10253</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997001.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10253"/>
    <dbReference type="EnsemblBacteria" id="EFK59336">
        <property type="protein sequence ID" value="EFK59336"/>
        <property type="gene ID" value="HMPREF0766_10253"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029631_3_2_10"/>
    <dbReference type="OrthoDB" id="1875497at2"/>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PTHR43448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="302" mass="33766" checksum="A2378B156DE38F89" modified="2010-10-05" version="1">MKQFISDFNKLVKLRLTLTVVFSASISFLIGATQQGEIIWFNWLLLTIGGFFVTGAANGFNEIIEKDLDKLMTRTEDRPLPAGRMTTGQALVLSLFMGIFGTLILVKLNFIAGLLSVFSIFLYAFVYTPLKQKSPIAVFVGAFPGALPPLIGYYAAFKSAGFGLEYAAISEAAVVITPLVLFVIQFVWQFPHFWAIAWVADDDYKKAGFRLLPTKERDRVSAWMLFISAVLMIPVGFLPMYFGFGGWIFTIVSLLGGLMFAWYGYKHLAEQSIGSAKRVMFTSFIYLPVTQLVLLLNFIPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHI7</accession>
    <name>D7VHI7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 9">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rplV</name>
        <name evidence="10" type="ORF">HMPREF0766_10456</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="5">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="6 9">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997494.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10456"/>
    <dbReference type="EnsemblBacteria" id="EFK59539">
        <property type="protein sequence ID" value="EFK59539"/>
        <property type="gene ID" value="HMPREF0766_10456"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083987_3_1_10"/>
    <dbReference type="OrthoDB" id="1666043at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK59539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="143" mass="16009" checksum="AF3EFD083F14AEBB" modified="2010-10-05" version="1">MEATRKLKKSVLIKQRKEQEKAQIGGASTAKLLNCPTSPRKMRLVVDLIRGEKVENALYILKHSSKEAASRVEKLLLSAIKNWEAHNEGQSVEDSALFVKEVSVGGGRQLKRLRPAPQGRGYRIRKRSNHVTLVVDSLNNVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHL5</accession>
    <name>D7VHL5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997543.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10484"/>
    <dbReference type="EnsemblBacteria" id="EFK59567">
        <property type="protein sequence ID" value="EFK59567"/>
        <property type="gene ID" value="HMPREF0766_10484"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50339SD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_209802_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="61" mass="6589" checksum="B9487C9077C4A7DD" modified="2010-10-05" version="1">MNPMNRIFPITLVILMTSLLTSCAAIEGIFKAGVWSGVIMVVVVVALLIWILAKLFGGNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHW2</accession>
    <name>D7VHW2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_10581</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997789.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10581"/>
    <dbReference type="EnsemblBacteria" id="EFK59664">
        <property type="protein sequence ID" value="EFK59664"/>
        <property type="gene ID" value="HMPREF0766_10581"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_1_2_10"/>
    <dbReference type="OrthoDB" id="208162at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="41"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="282"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="523" mass="58501" checksum="E40D3F1E6C268E7F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI06</accession>
    <name>D7VI06_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_10625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997883.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10625"/>
    <dbReference type="EnsemblBacteria" id="EFK59708">
        <property type="protein sequence ID" value="EFK59708"/>
        <property type="gene ID" value="HMPREF0766_10625"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_1_3_10"/>
    <dbReference type="OrthoDB" id="554994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="72"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="389"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="509" mass="58140" checksum="623C7BB10065FCFB" modified="2010-10-05" version="1">MKRYFNKKNVSCFLMLMTGLTGMITISCENKLDIDSANVASETKQWTDISDTRSSLMGLYGLTRAALQDNNAHWVYGEMRGKDFVSYKRSDLEAVYKNDLKASYPMISALSNWRRFYAVVNAASIFIERAPEVYEKDERYTELNLKYDIAQARAIRAFAYFYMVRIWGDVPLLTKSYDDGKFTEFGRTDQASVLAFASQELLKAAEDLPYLYGVNLQTYYGVTSVEWRGVLFNKLTAYALLAHIAAWQGKYIDADVFSKFVLDNYGKVGLFYSNISQLTGRTGIFSSSEKYSQLLNFQSSYAFNEATATGHIEQLTLAKPLTNKTMPDIFVPKDSVITIFNDPNDTRFGIDTISGLTRTNYFTNFSGEIPIFSKIKVIRDGDGDSDFNIFGSNLVFTRLEEITLLRAEAKAALGEISEARTLLNVIRTSRGLPAFHEGRTENIVDVIFEERRRELMGEGWRWYDIIRFNKLRKKDSNVVKLINDGGIYWPIATDVLRNNSQLVQNPYWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI71</accession>
    <name>D7VI71_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetyltransf_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FemABX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998010.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10690"/>
    <dbReference type="EnsemblBacteria" id="EFK59773">
        <property type="protein sequence ID" value="EFK59773"/>
        <property type="gene ID" value="HMPREF0766_10690"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055609_0_0_10"/>
    <dbReference type="OrthoDB" id="891566at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003447">
        <property type="entry name" value="FEMABX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51191">
        <property type="entry name" value="FEMABX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="2">
        <location>
            <begin position="158"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="353" mass="41606" checksum="3C033BE8C446F73E" modified="2010-10-05" version="1">MFKILDLSKKEDEDLYKSIIEERDFQSAYNRLEYFKVFCGGTNMLICFLYQEGTKVILLPGYLKQIKIYSSVKNTFDFSSPYGYTGPFFSTDVDEDNLSLFWEEVKNWQLNNNVVSEFIRFNLFNNSKGYNGTIQKTMLNIKGVIISEPDQWSSFEPKVRKNVKRAQRENLISKIYYRKIEQEYINEFYSIYIETMRRTNATDFFFYSLESFNSFILNNSELCAICTIYDDSKPISTELLLISDNSVFSFLGGTLVDAFEKRPNDFLKFEVINWARSMEFKYYVLGGGYGYEDGIFKYKKAFFPDDVIEYNTGRKIVNDDLYLSYVEEVNKAKENSNELDLNDTSFFPLYNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI90</accession>
    <name>D7VI90_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10709"/>
    <dbReference type="EnsemblBacteria" id="EFK59792">
        <property type="protein sequence ID" value="EFK59792"/>
        <property type="gene ID" value="HMPREF0766_10709"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3222237_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="44" mass="5367" checksum="832230705D1A91E2" modified="2010-10-05" version="1">MLLYVVDKVKKIDTLYRINTLFIHRIDENESISNPEIFLFFCFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIA4</accession>
    <name>D7VIA4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998078.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10723"/>
    <dbReference type="EnsemblBacteria" id="EFK59806">
        <property type="protein sequence ID" value="EFK59806"/>
        <property type="gene ID" value="HMPREF0766_10723"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025928_1_0_10"/>
    <dbReference type="OrthoDB" id="377914at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041662">
        <property type="entry name" value="SusD-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12771">
        <property type="entry name" value="SusD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="509" mass="57901" checksum="1822B973081FA662" modified="2010-10-05" version="1">MKKNIIYIICACVGMSVFFQSCDKNFQEINTDPNKSLEAYPYQFMAPALVNSVSYNMNRNRGFNNELMQVTVNVGDSEGKVFRYDFRRNWADYMWNNLYPVLNSWREMYKKADGGINDNASYRAISLINQSWIFSILTDTYGDIPYSQALLGKDSLIIEPKFDTQKDIYAAIFAKLDTANAWLKANKSINASQDPVFQGNVSRWRKLGNSLYLRLLLRVSGKPEVSALVQAKIKEILETNASNYPIMTSNDDSAILRWTGVAPYTSPFATVREADFRQPGIASFFIDNLVNWNDPRINTSLGTNGVNRWSIAPYQGGFVGVPSGYAPGEGFDRKAYFYSTNQKVGDYNATTLMTDPMTGMIMNFAELEFIKAEVALKGWTSKNAGELFKSGVKNSITLWLPTWSVPIDEYLDAADFNWSESESFEAKMQKIHLQKYYSLFLVDMQQWFEYRRTGYPVLPKGKGLQNNGEMPARMTYPVSIQSTNPTNYKLAIGIQGPDEINTKVWWQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VID1</accession>
    <name>D7VID1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lrp2</name>
        <name evidence="5" type="ORF">HMPREF0766_10750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998128.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10750"/>
    <dbReference type="EnsemblBacteria" id="EFK59833">
        <property type="protein sequence ID" value="EFK59833"/>
        <property type="gene ID" value="HMPREF0766_10750"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_0_0_10"/>
    <dbReference type="OrthoDB" id="1534467at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="156" mass="17680" checksum="BB719A499112C3C9" modified="2010-10-05" version="1">MPFQPDKTDLKILKLLQENGRVTNLQLASSIGLSPAPTLERVRKLENSGFIKSYHAFVDEEKLGLGIKSFIQISLDFHTHNAIPEFVEAVKGIPEVTECHHVTGNCDFILKVYVKDIKAYEAVIMEKISKIPFVKTFQTMMIMSTSKKEPIIPLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIJ6</accession>
    <name>D7VIJ6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998255.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10815"/>
    <dbReference type="EnsemblBacteria" id="EFK59898">
        <property type="protein sequence ID" value="EFK59898"/>
        <property type="gene ID" value="HMPREF0766_10815"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZVBS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3140824_0_0_10"/>
    <dbReference type="OrthoDB" id="2217587at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="49" mass="5806" checksum="B90A30C8EA4994A1" modified="2010-10-05" version="1">MNNLEKKTTESQVELKELTLEEQITINAGSRNDPKQEDLWDIISKWLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIJ9</accession>
    <name>D7VIJ9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC-type bacteriocin transporter</fullName>
            <ecNumber evidence="11">3.6.3.43</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">lktB2</name>
        <name evidence="11" type="ORF">HMPREF0766_10818</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.43" evidence="11"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998261.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10818"/>
    <dbReference type="EnsemblBacteria" id="EFK59901">
        <property type="protein sequence ID" value="EFK59901"/>
        <property type="gene ID" value="HMPREF0766_10818"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_10"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005074">
        <property type="entry name" value="Peptidase_C39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03412">
        <property type="entry name" value="Peptidase_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50990">
        <property type="entry name" value="PEPTIDASE_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C39" evidence="10">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="166"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="478"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="511"/>
            <end position="518"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK59901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="720" mass="80692" checksum="F1529192E6B3CE88" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIM5</accession>
    <name>D7VIM5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="12">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">rlmN</name>
        <name evidence="14" type="ORF">HMPREF0766_10844</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="12"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998315.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10844"/>
    <dbReference type="EnsemblBacteria" id="EFK59927">
        <property type="protein sequence ID" value="EFK59927"/>
        <property type="gene ID" value="HMPREF0766_10844"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029101_2_0_10"/>
    <dbReference type="OrthoDB" id="1111428at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="102"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="12">
        <location>
            <begin position="167"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="12">
        <location>
            <begin position="222"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="12">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFK59927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="352" mass="39647" checksum="0D3001A1B76E37CA" modified="2010-10-05" version="1">MAVKSNIIDIRSLTLDQLKQKLVEMGEQGFRAKQIYEWLWQKSCTDFDEMSNLSKALRDTLKANFAINAVTVKESQVSSDRTIKSSFWLYDNNVIEGVLIPTTDRMTACVSSQVGCSLTCKFCATGYMDRKRNLNADEIYDQVVLISKQAEEKYGQPLTNIVYMGMGEPLLNYANMMKSVERITSPDGLNMAAKRITVSTAGIAKMIKKLGDDGVKFNLALSLHAANDQKRNEIMPINEQNTLKALAEALKYFYLKTKSPITFEYIVFNNFNDELEDAKELARFCKHVPSKVNLIEYNPISLADFTNADADKIDVFAEYLRSQGIITNVRRSRGKDIDAACGQLAIKEEEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ86</accession>
    <name>D7VJ86_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="1">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoribosyl pyrophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">prs</name>
        <name evidence="9" type="ORF">HMPREF0766_11055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000448.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11055"/>
    <dbReference type="EnsemblBacteria" id="EFK58939">
        <property type="protein sequence ID" value="EFK58939"/>
        <property type="gene ID" value="HMPREF0766_11055"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_2_0_10"/>
    <dbReference type="OrthoDB" id="1011035at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK58939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="318" mass="34707" checksum="B357BD9301F80C80" modified="2010-10-05" version="1">MPLQFNTVKLFAGSGTQELSEKIAKSYGKPLGDKTLSKFSDGEIQPFYNESVRGSDVFLIQSTNQPTDNLLELLLMIDAAKRASAHYITAVVPYFGFARQDRKDKPRVAIGAKMIANLITASGAHRIMTMDLHAAQIQGFFDIPVDHLDGSVIFVPYIKSLNLPNLTIASPDMGGSYRARTFAKFFNAEVIICDKRRKRANEIESMSIIGDVTGQDVVLIDDICDTAGTLSKAAALIMENGAKSVRAVCTHAVLSGKAYETIENSVLTEMIVTDTIKLDADKMNTCSKIKVLSTADLFANAIKNVNEHSSISDLFQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJC8</accession>
    <name>D7VJC8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_11097</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000576.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11097"/>
    <dbReference type="EnsemblBacteria" id="EFK58981">
        <property type="protein sequence ID" value="EFK58981"/>
        <property type="gene ID" value="HMPREF0766_11097"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079503_3_3_10"/>
    <dbReference type="OrthoDB" id="1724595at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017003">
        <property type="term" value="P:protein-heme linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004329">
        <property type="entry name" value="CcmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036127">
        <property type="entry name" value="CcmE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03100">
        <property type="entry name" value="CcmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82093">
        <property type="entry name" value="SSF82093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="139" mass="15754" checksum="66047E2E784D23DE" modified="2010-10-05" version="1">MKKSSIILIIIIAIAIAMILVIYTDSSTYSTFTQAKEKKTELYVVGVLNKEKQLHYEPTKDANHFSFYMYDNDSTECQVVFNGAKPQDIERSEQIVLTGKMEGNVFHASKILMKCPSKYNQDQIEVTESAATPKTAYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJC9</accession>
    <name>D7VJC9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative cytochrome c-type biogenesis protein CcmF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ccmF</name>
        <name evidence="6" type="ORF">HMPREF0766_11098</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000578.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11098"/>
    <dbReference type="EnsemblBacteria" id="EFK58982">
        <property type="protein sequence ID" value="EFK58982"/>
        <property type="gene ID" value="HMPREF0766_11098"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015041_3_0_10"/>
    <dbReference type="OrthoDB" id="213184at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032523">
        <property type="entry name" value="CcmF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003567">
        <property type="entry name" value="Cyt_c_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43653">
        <property type="entry name" value="PTHR43653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16327">
        <property type="entry name" value="CcmF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01410">
        <property type="entry name" value="CCBIOGENESIS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="787"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="4">
        <location>
            <begin position="105"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="CcmF_C" evidence="5">
        <location>
            <begin position="355"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="822" mass="92527" checksum="BC1F53F50689C4AA" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJI0</accession>
    <name>D7VJI0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrABC system protein C</fullName>
            <shortName evidence="6">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">uvrC</name>
        <name evidence="9" type="ORF">HMPREF0766_11149</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UvrC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000654.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11149"/>
    <dbReference type="EnsemblBacteria" id="EFK59033">
        <property type="protein sequence ID" value="EFK59033"/>
        <property type="gene ID" value="HMPREF0766_11149"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014841_3_2_10"/>
    <dbReference type="OrthoDB" id="1036075at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="GIY-YIG" evidence="7">
        <location>
            <begin position="15"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="8">
        <location>
            <begin position="269"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="603" mass="70079" checksum="637AD4EB78C4CDE4" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJR6</accession>
    <name>D7VJR6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 19" type="primary">uvrB</name>
        <name evidence="19" type="ORF">HMPREF0766_11235</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000858.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11235"/>
    <dbReference type="EnsemblBacteria" id="EFK59119">
        <property type="protein sequence ID" value="EFK59119"/>
        <property type="gene ID" value="HMPREF0766_11235"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0556">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009621_2_1_10"/>
    <dbReference type="OrthoDB" id="95696at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="24"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="429"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="16">
        <location>
            <begin position="635"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="631"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFK59119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="677" mass="77382" checksum="1A43E8E366B5489A" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJS0</accession>
    <name>D7VJS0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nicotinamide-nucleotide adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000867.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11239"/>
    <dbReference type="EnsemblBacteria" id="EFK59123">
        <property type="protein sequence ID" value="EFK59123"/>
        <property type="gene ID" value="HMPREF0766_11239"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052648_3_0_10"/>
    <dbReference type="OrthoDB" id="1392851at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA_28" evidence="1">
        <location>
            <begin position="8"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="175" mass="20414" checksum="351DCDCF50F79253" modified="2010-10-05" version="1">MANQILKKIAVVGPESTGKSTIAQAIARHFNTVCVPEYAREYCKNLKNEYTLQDEVNMYYGQIALEDSLIPLSQHQILICDTTILTVKVWCDYLFGNTPEEVKNEIRHRDYDLYLLMDIDLPWEDDPLRDFPNEREHFLAVWKKELDSLEARYSLISGLGEERLKNALKAIEEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJS1</accession>
    <name>D7VJS1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">ahcY</name>
        <name evidence="9" type="ORF">HMPREF0766_11240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4 6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 6">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000870.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11240"/>
    <dbReference type="EnsemblBacteria" id="EFK59124">
        <property type="protein sequence ID" value="EFK59124"/>
        <property type="gene ID" value="HMPREF0766_11240"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0499">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_10"/>
    <dbReference type="OrthoDB" id="522981at2"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="8">
        <location>
            <begin position="197"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="163"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="226"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="305"/>
            <end position="307"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="438" mass="48111" checksum="24EDCDE2413D9E4D" modified="2010-10-05" version="1">MSSIESTYVPYKVKDISLAEWGRKEIELAEAEMPGLMSLREEFGAAKPLKGARIAGCLHMTIQTAVLIETLVELGADVTWSSCNIFSTQDHAAAAIAAAGIPVYAWKGMNAEEFDWCIEQTLYFGEDRQPLNMILDDGGDLTNMVFDKYPELISGIKGLSEETTTGVHRLYERMKNGTLHLPAINVNDSVTKSKFDNKYGCRESLVDAIRRATDLMLAGKVAVVAGYGDVGKGSAESLRSAGVRVIVTEIDPICALQAAMEGFEVKKFADAVKEANIVVTTTGNKDIVRAEHFKTMKDKTVVCNIGHFDNEIDVAWLNTNYGNTKIEIKPQVDKYTIDGNDIILLAEGRLVNLGCATGHPSFVMSNSFTNQTLAQLELWTNTAAYENKVYTLPKHLDEKVARLHLAKIGVELDTLTEDQAAYIGVTVDGPYKADAYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJY4</accession>
    <name>D7VJY4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">coaE</name>
        <name evidence="2" type="ORF">HMPREF0766_11303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998742.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11303"/>
    <dbReference type="EnsemblBacteria" id="EFK58586">
        <property type="protein sequence ID" value="EFK58586"/>
        <property type="gene ID" value="HMPREF0766_11303"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057180_3_1_10"/>
    <dbReference type="OrthoDB" id="1515383at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="195" mass="21669" checksum="C3AE89BEB29153ED" modified="2010-10-05" version="1">MGLKIGITGGIGAGKSIICNIFKVLGVPVYNADQEAKDIMIKSEEVKAALKETFGNETYFEDGSLNRAFLSSKVFGDEAQLKLLNGIVHPAVIRAGEEWSEKQTAVYSLKEAALLFETGSYRQLDYTILVTAPEDIRIARVVARDHTDEAKVRDRISKQMSDKEKSELADFIVINDGIQPLLPQVLHLHQQFLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK06</accession>
    <name>D7VK06_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_11325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998806.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11325"/>
    <dbReference type="EnsemblBacteria" id="EFK58608">
        <property type="protein sequence ID" value="EFK58608"/>
        <property type="gene ID" value="HMPREF0766_11325"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_1_10"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="145"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="216" mass="24639" checksum="F5BAB4B7653BF310" modified="2010-10-05" version="1">MSTRNILIADSHPVARLGVSTLLEQFLTDIDIYIASNFEELQSMLLVVKYDLLIMEIELPNGNWVAIVDQILSVQKDLKIIILSKQDNKFLASASFMKKTFAYVCKDQSIEYIRNVIQTVLSGSKHFRKEKTSQQFILKEPNNETQTISIILSPREMEVSFLLLKGSSIKDIAKVLNLSKTAVSTYKIRLFKKLGVKNIAELYNLLNHKQLPSFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK37</accession>
    <name>D7VK37_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pdhR</name>
        <name evidence="5" type="ORF">HMPREF0766_11356</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11356"/>
    <dbReference type="EnsemblBacteria" id="EFK58639">
        <property type="protein sequence ID" value="EFK58639"/>
        <property type="gene ID" value="HMPREF0766_11356"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_9_2_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="219" mass="25293" checksum="94282032A6AED223" modified="2010-10-05" version="1">MIKQKERLSDQVYKRIKSDIQQGLYLAGHKIPSESELMDIYKVGRSTVREAINSLASSGILVVKRGDGTYIRRLSEESAIDEHLRTANFEEVNDARRLLETELVRRACTYATTPQLDEIAHYLQLRKEAILIEDKSACIHADIQFHLRIASAANHHVFYILYQNFTHLISNFFQEREPRGISYFAMSHHLHTQLFEAIKAKDEQQALHVLAHILTNNHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK85</accession>
    <name>D7VK85_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999024.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11404"/>
    <dbReference type="EnsemblBacteria" id="EFK58687">
        <property type="protein sequence ID" value="EFK58687"/>
        <property type="gene ID" value="HMPREF0766_11404"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4818">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095018_2_1_10"/>
    <dbReference type="OrthoDB" id="2012653at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="108" mass="12132" checksum="BC70A7F8B96D8BF3" modified="2010-10-05" version="1">MDRKTTAIISYITLIGWLIAYFQYKDKTKDAFVSYHLKQSLGITIISILLGLVLNIVVIAVPALAVLTYANIFILILWILGIVNAVKEEMKPVPVVGTIFEQKFSFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK96</accession>
    <name>D7VK96_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flavoprotein family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yhiN</name>
        <name evidence="1" type="ORF">HMPREF0766_11415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999052.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11415"/>
    <dbReference type="EnsemblBacteria" id="EFK58698">
        <property type="protein sequence ID" value="EFK58698"/>
        <property type="gene ID" value="HMPREF0766_11415"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2081">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025174_2_0_10"/>
    <dbReference type="OrthoDB" id="1513550at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004792">
        <property type="entry name" value="BaiN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023166">
        <property type="entry name" value="HI0933-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42887">
        <property type="entry name" value="PTHR42887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00275">
        <property type="entry name" value="TIGR00275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="396" mass="43464" checksum="3B7552CE841CCED0" modified="2010-10-05" version="1">MQYDAVIIGGGACGLMCAVQAGLLGKKTLILERNNKPGAKILISGGGRCNYTNLGTTPANFVTQNPDFLHGIFKRWTVDDTVRFFESYGIFGQEKTLGQLFPITNKAKDIVGVFTNLMFETGQDIWLDSLVKSVDQADGGFRICVDTPSEEKTLKTAKVVMASGGLPVQKLGASDFALRLARRFELAIVPTAPALVPLTITGKDAEWYASLSGNSVFSRVYNKEISFEENILFTHWGLSGPAILQISSYWRAGQEFTIDLLPQFSMEQIIKDERNSGGKRLLSQVLNDYFTRKMVDAFGKFLPLTTKIASLSKADAKLIVETIHRFQVKPAGDKGYDKAEVMRGGVDTNELNSSTLESKRIPGLYFGGEAVDVTGWLGGYNFQWAWASAYTIAQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKD4</accession>
    <name>D7VKD4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter, major facilitator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11453</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11453"/>
    <dbReference type="EnsemblBacteria" id="EFK58736">
        <property type="protein sequence ID" value="EFK58736"/>
        <property type="gene ID" value="HMPREF0766_11453"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_16_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="37"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="448" mass="48650" checksum="78B21147DEF1049B" modified="2010-10-05" version="1">MFQFRSIVNHFFIFIDRSVPFGVFSKLFYMQNSWKKKFSIIWVGQFISLLSSTAVNFAVIIWLSLETGSAEVLAYAAIAGLLPQAIIGPIAGVYIDRWDRKKTMMFADGFVAFCTLIMSVSFYMGNESLLLLYVMLALRSVGSAFHMPAMQAAIPMLAPQSELLRIAGINQIIQSVSSIAGPALGALAIGFMSIGNVLLLDIAGAVVAIASLLFVHIPNPEIAEKAKASVQQVWKDINLGWEEIRKNRGLSYLFLYSVIATFCIMPVAVLFPLITINHFGGNKTEMSIVEMAWGVGMLVGGGLLGIWKPDIHKVIIINIMHMLLGISLAISGWLPVSGFILFVVLTGIGGLAASVYNASFMTVLQEEVNPAMMGRVFSMFFSIVVIPSVIGLLSTGFVADTIGVNLTFIILGLVVVGVGLLSFFTPSLMMLGKVKETTHKEAEPSEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKE1</accession>
    <name>D7VKE1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3347 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999165.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11460"/>
    <dbReference type="EnsemblBacteria" id="EFK58743">
        <property type="protein sequence ID" value="EFK58743"/>
        <property type="gene ID" value="HMPREF0766_11460"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101306_0_0_10"/>
    <dbReference type="OrthoDB" id="1905459at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021782">
        <property type="entry name" value="DUF3347"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11827">
        <property type="entry name" value="DUF3347"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107042" description="DUF3347 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3347" evidence="2">
        <location>
            <begin position="55"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="190" mass="21500" checksum="2566A9476F3A5EED" modified="2010-10-05" version="1">MKRMIILLLAPLLLMACQSGTTSNKSHPEDSASSLKDSLEAYSAETSGTDSSSSVVTAYLDLGKSLYIQDQDKIMKAANFFAQILKIQHPDETNVNSREDIKDILENTTENIQHILDSKDNLIHQREHYEIISQDIYDYIKLVGIQHTLYKFDCKLSSKPQTWLSDTREVQNPYLGIEKKVCGTLTETLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKE3</accession>
    <name>D7VKE3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Copper-resistance protein, CopA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_11462</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999177.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11462"/>
    <dbReference type="EnsemblBacteria" id="EFK58745">
        <property type="protein sequence ID" value="EFK58745"/>
        <property type="gene ID" value="HMPREF0766_11462"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009100_0_1_10"/>
    <dbReference type="OrthoDB" id="971126at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13848">
        <property type="entry name" value="CuRO_1_CopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13874">
        <property type="entry name" value="CuRO_2_CopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13896">
        <property type="entry name" value="CuRO_3_CopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034284">
        <property type="entry name" value="CuRO_1_CopA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034282">
        <property type="entry name" value="CuRO_2_CopA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034279">
        <property type="entry name" value="CuRO_3_CopA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="36"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="3">
        <location>
            <begin position="226"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="442"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="751" mass="86222" checksum="FB1D967A4386B1D7" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKG2</accession>
    <name>D7VKG2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999230.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11481"/>
    <dbReference type="EnsemblBacteria" id="EFK58764">
        <property type="protein sequence ID" value="EFK58764"/>
        <property type="gene ID" value="HMPREF0766_11481"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010457_3_0_10"/>
    <dbReference type="OrthoDB" id="1706506at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011935">
        <property type="entry name" value="CHP02231"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037291">
        <property type="entry name" value="DUF4139"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025554">
        <property type="entry name" value="DUF4140"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005">
        <property type="entry name" value="PTHR31005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13598">
        <property type="entry name" value="DUF4139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13600">
        <property type="entry name" value="DUF4140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02231">
        <property type="entry name" value="TIGR02231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4140" evidence="3">
        <location>
            <begin position="35"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4139" evidence="2">
        <location>
            <begin position="219"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="543" mass="60245" checksum="DE99548B52991F16" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKK1</accession>
    <name>D7VKK1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999339.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11520"/>
    <dbReference type="EnsemblBacteria" id="EFK58803">
        <property type="protein sequence ID" value="EFK58803"/>
        <property type="gene ID" value="HMPREF0766_11520"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50330D3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182198_0_0_10"/>
    <dbReference type="OrthoDB" id="1973287at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025629">
        <property type="entry name" value="DUF4287"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14117">
        <property type="entry name" value="DUF4287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="72" mass="7981" checksum="044EA87DD1352AD9" modified="2010-10-05" version="1">MSFQAYIENIETKTGKSPEDLQALATGKGFVENGKLKSDVKAAQIIEWLKADFDLGHGHAMSIYAYFKGKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKM9</accession>
    <name>D7VKM9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999395.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11548"/>
    <dbReference type="EnsemblBacteria" id="EFK58831">
        <property type="protein sequence ID" value="EFK58831"/>
        <property type="gene ID" value="HMPREF0766_11548"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZHCT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054360_0_0_10"/>
    <dbReference type="OrthoDB" id="983011at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107248" evidence="1">
        <location>
            <begin position="21"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="336" mass="39122" checksum="CE731DABEF9DCE86" modified="2010-10-05" version="1">MVRRLITSLLLLLLYTNSNAQNVGYQIDFLGYADNREFKAPYTESKTIFGTRISPELYFKLSDNHTVHGGIHVAQEFGEREHKNPMLRPIIYYNYKNENFDFSIGHIPRYDLMKNTPRAILNDTLIYFRPNIEGMMLAYRNDHFQQRLFIDWTSKQSDKYREEFLVGMNGKVTVGDFYFSDDLILWHNALSANSNIDEHIQDNGVGIFKLGSNLTNKTPLDSLIIDAGIMMGIDRIRSQYDFRVKKGFIANVYMAFKSFSLENTFYKGGSQNTPYADSYYRYSTYDRLDVGWSPIQSANIQGTLKLALHFTPGRIDNQQMFTLRYLLNRAIRVNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKN8</accession>
    <name>D7VKN8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
            <ecNumber evidence="2">1.1.1.276</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sdh</name>
        <name evidence="2" type="ORF">HMPREF0766_11557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.276" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999412.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11557"/>
    <dbReference type="EnsemblBacteria" id="EFK58840">
        <property type="protein sequence ID" value="EFK58840"/>
        <property type="gene ID" value="HMPREF0766_11557"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_10"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031132">
        <property type="term" value="F:serine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="254" mass="27852" checksum="E911B03FE35EE35B" modified="2010-10-05" version="1">MEKIAFITGASSGIGAACAEVLAKEGYHLLLCARRIERLEELKQHISAQYPDCNIYIFKLDVRNAEEVQLSVNNLPEKWKNIDVLINNAGLSQGLDPIQNGDIGDWDRMIDTNIKGLLYVTRTVVPFMEARKKGHIVNLGSIAGKEVYPNGNVYCATKHAVDALNKAMRIDLLSKGIKVTGINPGMVETEFSEVRFHGDTDRAAAVYKDITPLSGKDIAETIAFVLSRPAHVNINDLLIMPAAQATGTIVHRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKP4</accession>
    <name>D7VKP4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="6" type="ORF">HMPREF0766_11563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999425.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11563"/>
    <dbReference type="EnsemblBacteria" id="EFK58846">
        <property type="protein sequence ID" value="EFK58846"/>
        <property type="gene ID" value="HMPREF0766_11563"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_0_3_10"/>
    <dbReference type="OrthoDB" id="1463423at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="74"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="148"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="189"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="294" mass="32753" checksum="B19F8C3609255B80" modified="2010-10-05" version="1">MKIAIYGREFNLSVLSYVQQLFDFLNKKDLEICIYADFYEFLKSKFPCQDNLSTFTSHEDIPKDVAFMLSLGGDGTMLSAVSIIKDSGLPVAGINFGRLGFLATINKTDIEKALIQILNNAYTLQKRALLTVESDEEKLFEGKNFALNDITVFRYDSSAMITVNAHINGELLNSYWADGLIIATPTGSTAYSLSCGGPIIMPGSGNFVVTPISPHNLNVRPIVISSDFELDLEIESRTGKYILSCDSQSVTLSSTTKLKIKKAPFFINLIRLDKEGYFSTLREKLLWGIDVRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKR8</accession>
    <name>D7VKR8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999464.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11587"/>
    <dbReference type="EnsemblBacteria" id="EFK58870">
        <property type="protein sequence ID" value="EFK58870"/>
        <property type="gene ID" value="HMPREF0766_11587"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032SKE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_859692_0_0_10"/>
    <dbReference type="OrthoDB" id="1299905at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032173">
        <property type="entry name" value="DUF5007"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16398">
        <property type="entry name" value="DUF5007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="359" mass="40622" checksum="11C107E9E390E6A7" modified="2010-10-05" version="1">MTTMKSTIKLWTMVATIAAVGFGSCKKVETGYLSDNIRYASNPVTVEQGVFVITQGIIPDASTPPFKITLLDIRNKETGKREEAFYKDYNVTVWKQPYNPKTDTTLALITAKQGIEKKAAFSVLEKSGQFLFTQATDSIPAGDYLVDIRVENPRGVKTYEGVTTIRIKPVQQYTYENVPYFLALPANSETAIRFPYDDQWFNPDKGQSASMTLKITRVADGPNQIVLKVVDKNGKVFPGKALERRPSGNSYLNTLSTFAYKTTVTDTAVLYDYAQARFPDVYWDTQTNGINCYYRIYEKWLASVDKVDPASWNPPNSVDYLTYTDQPVKINIRFNTKIYKPGKYIYEMKLRATLKEGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKS2</accession>
    <name>D7VKS2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11591"/>
    <dbReference type="EnsemblBacteria" id="EFK58874">
        <property type="protein sequence ID" value="EFK58874"/>
        <property type="gene ID" value="HMPREF0766_11591"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3276843_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="41" mass="4759" checksum="DFA7BA8D98C27C7C" modified="2010-10-05" version="1">MATNTSSFKTEISKRDKPSEYFLTSGQAIAIRIFLQIRDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKS5</accession>
    <name>D7VKS5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 10">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2 7 10">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">pgk</name>
        <name evidence="12" type="ORF">HMPREF0766_11594</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 10">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2 7 10"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999473.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11594"/>
    <dbReference type="EnsemblBacteria" id="EFK58877">
        <property type="protein sequence ID" value="EFK58877"/>
        <property type="gene ID" value="HMPREF0766_11594"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025427_0_2_10"/>
    <dbReference type="OrthoDB" id="462069at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="19"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="58"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="353"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK58877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="396" mass="42522" checksum="2FD03105C0A2FAD2" modified="2010-10-05" version="1">MKTIDDLNFSGKKALIRVDFNVPLDDQFNITDDNRIQGAAPTIKKILKDGGSVILMSHLGRPKDGPTDKYSLKHIVSHLSKVLGVDVQFAADCIGQEAVDKAASLKSGEVLLLENLRFYKEEEKGDVAFAEKLSKLGDVYVNDAFGTAHRAHASTAVIAQFFPGNKYFGYLMAAEVQNAEKVLNHPERPFTAIMGGAKVSDKLELIEALLEKVDNLIIGGGMAYTFVKARGGEIGQSLVELDKLDLANHLVKKAEEKGVNLVLPTDSQIADRFANDAEVYDGPNDQIPADKMGLDIGKESGEHFAEIISASKTILWNGPMGVFEMDTFAKGTKAVADAVVAATERGAFSLIGGGDSAAAVSKFKMTEHVSYVSTGGGALLEYMEGKELPGVKAINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKW3</accession>
    <name>D7VKW3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0766_11632</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11632"/>
    <dbReference type="EnsemblBacteria" id="EFK58236">
        <property type="protein sequence ID" value="EFK58236"/>
        <property type="gene ID" value="HMPREF0766_11632"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07660">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0798">TonB box</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="STN" evidence="8">
        <location>
            <begin position="57"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="9">
        <location>
            <begin position="242"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="615"/>
            <end position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK58236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1211" mass="135003" checksum="E396C879AEDEDF63" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKZ9</accession>
    <name>D7VKZ9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase, S54 family</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11668</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999670.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11668"/>
    <dbReference type="EnsemblBacteria" id="EFK58272">
        <property type="protein sequence ID" value="EFK58272"/>
        <property type="gene ID" value="HMPREF0766_11668"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055068_4_1_10"/>
    <dbReference type="OrthoDB" id="2053476at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="43"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="225" mass="25344" checksum="CBBF6734F5A3A605" modified="2010-10-05" version="1">MFPNLSPVVKNLLIINIIFFIGSSLVSQSYEYLAAFYPDSPYFKVWQIITYMFMHGGFTHIFFNMFSLLMFGPMIEQVLGSKRFLNFYLFTGLGALVLQYGIQAIELYQLVGTSFPVRQGIDMNALSFEQIAFIKEINYTPLVGASGAIYGILLAFAYLFPNIPLQLIFIPIPIKAKYFIGGLIVIEIYLSLSRPGDSVAHLAHVGGALFAFILLKMWGIRKGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL14</accession>
    <name>D7VL14_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999713.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11683"/>
    <dbReference type="EnsemblBacteria" id="EFK58287">
        <property type="protein sequence ID" value="EFK58287"/>
        <property type="gene ID" value="HMPREF0766_11683"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033YPE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2048232_0_0_10"/>
    <dbReference type="OrthoDB" id="2151242at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="133" mass="15331" checksum="3EBEA27BF8BF8211" modified="2010-10-05" version="1">MKNKALPFYKTTFVILLLVQAFLIFSDNEICFRTGLGILLSYLLIPIWNLLLKRGRKNMQILFKLYIIICGLFFIMSGAYLLATHIMITDYFMLSLAVKGLLMGIGVVIIFKYQELTEMYQAYLGRGIKSIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL26</accession>
    <name>D7VL26_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma factor regulatory protein, FecR/PupR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999737.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11695"/>
    <dbReference type="EnsemblBacteria" id="EFK58299">
        <property type="protein sequence ID" value="EFK58299"/>
        <property type="gene ID" value="HMPREF0766_11695"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050192_1_0_10"/>
    <dbReference type="OrthoDB" id="1381035at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032508">
        <property type="entry name" value="FecR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16344">
        <property type="entry name" value="DUF4974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="174"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4974" evidence="3">
        <location>
            <begin position="312"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="381" mass="43621" checksum="39EA2882BD3DAA84" modified="2010-10-05" version="1">MLTKEEYIRLYEKYQQGLCTEEEYIMLESYEDSFELEETNWNEMRMGKKEDVKRRIHGKIKDHIKISHFRKYKILYRGIQTAAAVLILCFGAYWLWNLKDDSGNNLRAKVVNKKILPGGNKATLTLDNGTEVDLNALKTGDLTFEGQVVASKNAEGQLTYDQPSSVASKISYHVLRTPRGGQYQIDLSDGTRVWLNAESSVRFPTSFTGEERVVEITGEVFFDVQKQNGKPFIVKTADQKITVLGTRFNVNAYVEESSVQTSLIEGKILLDVNSKRYNLNPGQRTTYDKGSKRVDTETFNPKEILAWQSGNFFFDAEGIESIMRKIARWYDVEIVYQGDMKDKIFSGTISRFGEVQDVLDMLALTGSVKFRIEGRRIYVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL36</accession>
    <name>D7VL36_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, 2OG-Fe(II) oxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999747.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11705"/>
    <dbReference type="EnsemblBacteria" id="EFK58309">
        <property type="protein sequence ID" value="EFK58309"/>
        <property type="gene ID" value="HMPREF0766_11705"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_6_3_10"/>
    <dbReference type="OrthoDB" id="400496at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="170"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="320" mass="36358" checksum="6C3221AB95145CB2" modified="2010-10-05" version="1">MALVNIPRLDLLNYTSGSKEQREQFIQDIGKAFNETGFVTIANHGLSKELIDELYQVVPAFFALPDDTKYQYEFPELAGQRGYTTKGREKAKDSKTPDLKEFWQRGQTIVGEEYSKTDFPDNPEVKELPRFNTITAEVYKKLEDTGRQLLKAIATYLDLEENYFEQYVINGNSILRAIHYFPILHPEELAPDAVRAGAHEDINLITLLIGASADGLEVLTKDGEWYPIKAKGEDIVINVGDMLQRLTNNKLKSTTHRVVNPPLEKMGTSRFSIPFFLHPKSSMSLACLSSCIDEKHPKAYPDYTAGEYLDERLREIGLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLA9</accession>
    <name>D7VLA9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4HBT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999947.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11778"/>
    <dbReference type="EnsemblBacteria" id="EFK58382">
        <property type="protein sequence ID" value="EFK58382"/>
        <property type="gene ID" value="HMPREF0766_11778"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_13_1_10"/>
    <dbReference type="OrthoDB" id="2060970at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="52"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="142" mass="15508" checksum="A00BAA745BFC50E3" modified="2010-10-05" version="1">MSSIWFKEYNLDELNVIFAKNMTGFLGIKATELTENSITATMPVNEKTKQPFGLLHGGASAVLAESVGSIASNMVVNDEKYMGVGLEINANHIRSATDKEVTAICSPLHIGATTHVWDIRINNHRGQLLCISRLTVAIVPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLW4</accession>
    <name>D7VLW4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-hydroxylase, aspartyl/asparaginyl family</fullName>
            <ecNumber evidence="2">1.14.11.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aspH</name>
        <name evidence="2" type="ORF">HMPREF0766_11961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.16" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK57969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001047.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11961"/>
    <dbReference type="EnsemblBacteria" id="EFK57969">
        <property type="protein sequence ID" value="EFK57969"/>
        <property type="gene ID" value="HMPREF0766_11961"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092409_0_0_10"/>
    <dbReference type="OrthoDB" id="1564693at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062101">
        <property type="term" value="F:peptidyl-aspartic acid 3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018193">
        <property type="term" value="P:peptidyl-amino acid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007803">
        <property type="entry name" value="Asp/Arg/Pro-Hydrxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05118">
        <property type="entry name" value="Asp_Arg_Hydrox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asp_Arg_Hydrox" evidence="1">
        <location>
            <begin position="14"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="225" mass="26331" checksum="0AC77B89E724A466" modified="2010-10-05" version="1">MKNFIKFDVQYDVAQLQQELAYCLKEVWTDHFNTKDYQGRWECISLRSETGNQQDIRSNPGNNTFQDTTLLQHVPYIRSIIDSWNFEKESIRLMALYPGSEIKPHRDPGCRYQDGALRLHIPVVTHPLVQFNVDGEDLKLEEGNCWYIDFSKVHWIRNSSDTVRVHLVIDGKSNPDMDKVFESHGIPSNEKPVYDERTKQAMIAQLELMDTDTARQIIKQLKDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM47</accession>
    <name>D7VM47_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dnaE2</name>
        <name evidence="9" type="ORF">HMPREF0766_12044</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001289.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12044"/>
    <dbReference type="EnsemblBacteria" id="EFK58052">
        <property type="protein sequence ID" value="EFK58052"/>
        <property type="gene ID" value="HMPREF0766_12044"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001600_1_0_10"/>
    <dbReference type="OrthoDB" id="561611at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Exonuclease" evidence="7">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="POLIIIAc" evidence="8">
        <location>
            <begin position="260"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK58052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1474" mass="165674" checksum="99E03387075BBA63" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM76</accession>
    <name>D7VM76_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">M42 glutamyl aminopeptidase</fullName>
            <ecNumber evidence="9">3.2.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">celM</name>
        <name evidence="9" type="ORF">HMPREF0766_12073</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="9"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001358.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12073"/>
    <dbReference type="EnsemblBacteria" id="EFK58081">
        <property type="protein sequence ID" value="EFK58081"/>
        <property type="gene ID" value="HMPREF0766_12073"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047249_1_0_10"/>
    <dbReference type="OrthoDB" id="900854at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK58081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="372" mass="41763" checksum="C65F3620307936BC" modified="2010-10-05" version="1">MAKKSEKTEKKHIPIVTKESLSFFEKYINNPSPTGFEWEGQRMWLDYLKPYVDTTYIDNYGTAVGIINPDAPYKVVIEAHADEISWFVNYITKDGLIYVIRNGGSDHQIAPSKRVNIHTDKGTVKAVFGWPAIHTRSGEKEEAPTLKNIFLDCGCTSKEEVEALGIHVGSVVTYEDEFMILNDRYYVGRALDNRAGGFMITEVARLLKENKKKLPFGLYIVNSVQEEIGLRGAEMIADYIKPHVAIVTDVTHDTQTPMINKITQGDLACGSGPVLSYAPAVQINLNKLLVRVAEQNQIPFQRQASSRYTGTDTDAFAYSNGGVPSALISLPLRYMHTTVEMIHKEDVDNVIRLIYETVLAIEEGQDFRTFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMB9</accession>
    <name>D7VMB9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001433.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12116"/>
    <dbReference type="EnsemblBacteria" id="EFK58124">
        <property type="protein sequence ID" value="EFK58124"/>
        <property type="gene ID" value="HMPREF0766_12116"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034649_0_0_10"/>
    <dbReference type="OrthoDB" id="620166at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107429" evidence="2">
        <location>
            <begin position="23"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="520" mass="58138" checksum="E7C69423C53DDE22" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMI8</accession>
    <name>D7VMI8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="2">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 7" type="primary">sucD</name>
        <name evidence="7" type="ORF">HMPREF0766_12208</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992612.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12208"/>
    <dbReference type="EnsemblBacteria" id="EFK57135">
        <property type="protein sequence ID" value="EFK57135"/>
        <property type="gene ID" value="HMPREF0766_12208"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052104_0_0_10"/>
    <dbReference type="OrthoDB" id="1081709at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2 3">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="290" mass="29904" checksum="F55E8E998CC5604D" modified="2010-10-05" version="1">MSVLVNKDSKVIVQGFTGTEGTYHATQMIEYGTNVVGGVTPGKGGQQHLDRPVFNTVQDAVDKTGANVSIIFVPPAFAADAIMEAAAAGIEVIVCITEGIPTKDMIQVKSYLSDKNSRLIGPNCPGIITADEAKIGIMPGFIFKKGNVGIVSKSGTLTYEAVDQTVKAGLGITTAIGIGGDPIIGTTTKEAVELLMNDPETKGIIMIGEIGGGMEAEAARWIKEHGTKPVVGFIAGQTAPPGRRMGHAGAIVGGADDTAAAKMKIMAECGIRVVESPAEIGKAIAEELAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMQ5</accession>
    <name>D7VMQ5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pectinesterase</fullName>
            <ecNumber evidence="3">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_12275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992735.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12275"/>
    <dbReference type="EnsemblBacteria" id="EFK57202">
        <property type="protein sequence ID" value="EFK57202"/>
        <property type="gene ID" value="HMPREF0766_12275"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012243_3_1_10"/>
    <dbReference type="OrthoDB" id="1095798at2"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045330">
        <property type="term" value="F:aspartyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pectinesterase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="320" mass="36209" checksum="EBBEE72D0D119640" modified="2010-10-05" version="1">MRNLVLFTVMLFTGLQYAVARSYDYCVAQDGSGQFKTVQEALNAVPDFRKTVTTIYIKNGIYKEKLILAGSKQNVRLIGEQVEKTILTYDDFAQRKNTFGEEKGTSGSSSVYLYGDGFVAENITFQNSAGPVGQAVAVWVASDRAVFSNCRFLGFQDTLYTYGKGSRQYYYNCYIEGTVDYIFGSSTAWFEECELYCKNSGYITAASTPDTVAYGYVFNKCRVTGDKDTKRFYLGRPWRPYAKVIFMNTQLPAFIASEGWHNWGKESNEQTVLYAEYNNTGAGSLSQNRVKWSHQLSEDEAKKVTLEAVFKDWNPLLSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMZ3</accession>
    <name>D7VMZ3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">atpG</name>
        <name evidence="10" type="ORF">HMPREF0766_12363</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992881.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12363"/>
    <dbReference type="EnsemblBacteria" id="EFK57290">
        <property type="protein sequence ID" value="EFK57290"/>
        <property type="gene ID" value="HMPREF0766_12363"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0224">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050669_0_1_10"/>
    <dbReference type="OrthoDB" id="1701531at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK57290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="297" mass="32692" checksum="9EF92036950E9DA9" modified="2010-10-05" version="1">MANLKEVRNRITSVSSTQQITKAMKMVSAAKLKRATNAIVQLRPYATKLRDILADVSASVEGNDSPFTKDREPNKVLLIVVSSNRGLAGAFNANVIKATNNLVASKYAEQLRKGNVSIIAIGKKGNDFYAKRDAYHVIANHSDLFAELNFENTSKITEFVMEQFKLGNFDRVEVIYNQFRNAAVQVLTAEQILPLLPGEDSKPKDKQPKEVDYIIEPSKEKIIEELIPKAIKTQLYKAILDSHASEHGARMTAMDKATENAGDLLKALKLSYNQARQAAITTELTEIVSGAAALSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN21</accession>
    <name>D7VN21_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992918.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12391"/>
    <dbReference type="EnsemblBacteria" id="EFK57318">
        <property type="protein sequence ID" value="EFK57318"/>
        <property type="gene ID" value="HMPREF0766_12391"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2262042_0_0_10"/>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="103" mass="11667" checksum="890F2C29111EADCF" modified="2010-10-05" version="1">MATKGQKIKTFRMMKGITQEQLAEKFNGNKSTVSRIENDTMEPNAQVLAALASFGMNIDDLLQAENGYVKEKALQMRVTELELKLMQIESKLEGLVKFIEEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN66</accession>
    <name>D7VN66_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992979.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12436"/>
    <dbReference type="EnsemblBacteria" id="EFK57363">
        <property type="protein sequence ID" value="EFK57363"/>
        <property type="gene ID" value="HMPREF0766_12436"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032UBB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1676734_0_0_10"/>
    <dbReference type="OrthoDB" id="1718582at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="157" mass="18117" checksum="2242A8C6FCF62F9A" modified="2010-10-05" version="1">MTSQYKLNNNDLYTIFGVVVEGGSNSFLAYPSRKDSMTHDFTDKNGLDIDLQDPRFNSREFTLNCALTASSVEDFWTKYNALFTELSNSGTHKLSITDLGKDYRVYYKEQRNIRKLTPLSGKPEVWIKFDLVFGEANWTDNIESVYLIDHDGNYLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN71</accession>
    <name>D7VN71_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992985.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12441"/>
    <dbReference type="EnsemblBacteria" id="EFK57368">
        <property type="protein sequence ID" value="EFK57368"/>
        <property type="gene ID" value="HMPREF0766_12441"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2275664_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="102" mass="12018" checksum="538C1F3B5D061726" modified="2010-10-05" version="1">MKENEDYIGNRVNDLGKIYKWIKDNPMAFLCSVMTVIAFLFIWLFVDAKNENIRITQQMSKQITDEVRRQVPISVREQLQPIKDSVDNTKSNIDKLIERVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN76</accession>
    <name>D7VN76_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12446"/>
    <dbReference type="EnsemblBacteria" id="EFK57373">
        <property type="protein sequence ID" value="EFK57373"/>
        <property type="gene ID" value="HMPREF0766_12446"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2737992_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="71" mass="8816" checksum="91A85AAC845685EC" modified="2010-10-05" version="1">METFKLDYNENSKLWICIHPDTGVYCQFKQYYFRRTYEFNIFEYSTNPIDELCDIIDSMITWLYEHHSNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNA0</accession>
    <name>D7VNA0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993021.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12470"/>
    <dbReference type="EnsemblBacteria" id="EFK57397">
        <property type="protein sequence ID" value="EFK57397"/>
        <property type="gene ID" value="HMPREF0766_12470"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_5_1_10"/>
    <dbReference type="OrthoDB" id="2057904at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="122" mass="14175" checksum="20E0F3026B0079E8" modified="2010-10-05" version="1">MGKRKENSTNSLNESYIVENCDLTYAVCKIGGRWKLLILCKLENGKLRFSELRNQINGITERMLTLQLRELEKEGLVKRTVYAEVPPRVDYELTAIAKELVPIWSQLSQWGAKHKNLVQQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNB2</accession>
    <name>D7VNB2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12482"/>
    <dbReference type="EnsemblBacteria" id="EFK57409">
        <property type="protein sequence ID" value="EFK57409"/>
        <property type="gene ID" value="HMPREF0766_12482"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199837_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025842">
        <property type="entry name" value="Bacteroid_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026437">
        <property type="entry name" value="CxxCx5CxxC_targ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14406">
        <property type="entry name" value="Bacteroid_pep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04139">
        <property type="entry name" value="CxxCx5CxxC_targ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="62" mass="6916" checksum="C44D7BEAE68F1DAF" modified="2010-10-05" version="1">MKSFSSLENKKLDLNSSTAVLGSLEAGPKYIASNFLNENGCRDVDYYHGGKWRARFYDCSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNF2</accession>
    <name>D7VNF2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6 7" type="primary">rplM</name>
        <name evidence="7" type="ORF">HMPREF0766_12522</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993090.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12522"/>
    <dbReference type="EnsemblBacteria" id="EFK57449">
        <property type="protein sequence ID" value="EFK57449"/>
        <property type="gene ID" value="HMPREF0766_12522"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082184_2_2_10"/>
    <dbReference type="OrthoDB" id="1822215at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="147" mass="16595" checksum="F1875C0059D68A64" modified="2010-10-05" version="1">MNTLSYKTVSANKNTVNKEWIVVDAEGEILGRLASEIAKVIRGKHKPTFTPHVDCGDNVIVINADKIRLTGDKLGDKVYVRYTGYPGGQRFITPKELLAKHPERIIEKAVRGMLPKNRLGRQLFKNLYVYAGTEHKHDAQNPKPVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNH6</accession>
    <name>D7VNH6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NifU-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993121.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12546"/>
    <dbReference type="EnsemblBacteria" id="EFK57473">
        <property type="protein sequence ID" value="EFK57473"/>
        <property type="gene ID" value="HMPREF0766_12546"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0694">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060555_0_2_10"/>
    <dbReference type="OrthoDB" id="2010888at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="SSF110836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nfu_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="184" mass="20387" checksum="40C41F110537E17B" modified="2010-10-05" version="1">MATINVYTESTPNPATMKFLVNKLLINGSLDYPNKEKAQESPFAFELFKFNFVTGVFFASNFVTITKSDDVEWSDIEAILKDFVKGAVESELAVKEVHHDEDTNFEGTEVEVKIQQVLHDYVRPAVEQDGGAIHYKSFDNGIVTVELRGSCSGCPSSTITLKSGIEGLLKRMVPEVEEVVAEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNJ7</accession>
    <name>D7VNJ7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PRTRC system protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12567</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993149.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12567"/>
    <dbReference type="EnsemblBacteria" id="EFK57494">
        <property type="protein sequence ID" value="EFK57494"/>
        <property type="gene ID" value="HMPREF0766_12567"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8BB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095268_0_0_10"/>
    <dbReference type="OrthoDB" id="1478045at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022273">
        <property type="entry name" value="PRTRC_protein-E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19556">
        <property type="entry name" value="PRTRC_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03741">
        <property type="entry name" value="PRTRC_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRTRC_E" evidence="3">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="92"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="202" mass="23090" checksum="3C702C97E9376481" modified="2010-10-05" version="1">MNTNFFNQVQQLDFTGILQLNISKGIENKLIVTVLLNNEQCGDSAKNLIPPLIFNATSQEFDEGFFEQINAPIKAISGLMVDMEAFMKQMETVKLQSEMEKQKTEKAKKEKETKDKKYKDGMAKVDELEKEGKFREAWMKVPDITEFPEKADEIRKRKTSLSDKFGTPSLFGGVTEEQPEPPKTEEVATYCPINTTNEEVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNP2</accession>
    <name>D7VNP2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993211.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12612"/>
    <dbReference type="EnsemblBacteria" id="EFK57539">
        <property type="protein sequence ID" value="EFK57539"/>
        <property type="gene ID" value="HMPREF0766_12612"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178571_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="103" mass="11825" checksum="060B80595CDE5C90" modified="2010-10-05" version="1">MRVNRIPKKLLSRRSHVAVPTSSIIQKINVRKTAVSLRMTRAMNALEIVDLRPATALLIVFLQHPHFLGTLKILFFLKVKNHTLYTKNPFILQGNLPFGNRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNY8</accession>
    <name>D7VNY8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12708"/>
    <dbReference type="EnsemblBacteria" id="EFK57635">
        <property type="protein sequence ID" value="EFK57635"/>
        <property type="gene ID" value="HMPREF0766_12708"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3140827_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="49" mass="5746" checksum="82A58A3C99ACFB09" modified="2010-10-05" version="1">MDIVIRHKQIAAVRRIAEAENFQLAANCSHYLFVDQQVLFISFVQQNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNZ4</accession>
    <name>D7VNZ4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12714"/>
    <dbReference type="EnsemblBacteria" id="EFK57641">
        <property type="protein sequence ID" value="EFK57641"/>
        <property type="gene ID" value="HMPREF0766_12714"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134973_0_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107091" evidence="1">
        <location>
            <begin position="31"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="125" mass="13767" checksum="BF32696BE92AE9F3" modified="2010-10-05" version="1">MGTTKTQIFMKSLKMIAIVALTMFGTAALAQSKTEKIKVLGNCGMCKKRIEASLKDEAITNADWDKNSKILTVTYNSNKINSQTIQQKIANAGHDTPQVKAKNEIYDKLPGCCQYDRTGKPSKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP12</accession>
    <name>D7VP12_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5009 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993417.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12732"/>
    <dbReference type="EnsemblBacteria" id="EFK57659">
        <property type="protein sequence ID" value="EFK57659"/>
        <property type="gene ID" value="HMPREF0766_12732"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4299">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_582372_0_0_10"/>
    <dbReference type="OrthoDB" id="768508at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032176">
        <property type="entry name" value="DUF5009"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16401">
        <property type="entry name" value="DUF5009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5009" evidence="2">
        <location>
            <begin position="5"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="461" mass="52509" checksum="28F692E074D436DE" modified="2010-10-05" version="1">MQVKRNNSLDTLRGIAILLMVLSASIAFGVMPGWMYHAQVPPPDHQFNPAIAGITWVDLVFPFFLFSMGAAIPLSMQNKLTRLSSWQILLSIAKRFILLVFFALFTMHARAWVLSDSPGTKEYVLSILSFGLLFLIYVDLEQKIGKRNDWIVKIISYLACAAIVFWGKDQDKSFNIHNPDIIILVLANMALFGTLIWWLTAKNIWIRMGVLPLIMAVFLASKNEGSINYYIYNWTPADWLYKFYYLKYLFIILPATLVGEWIITEQKSPSDWKTCKSSYLMVGMIGFLLLLGNVILLYSRELVLNFFLSVVLMFTAVYLIRKIGTVNIISRLVYTGSYLLLLGLLLESYEGGIKKDFSTYSYYFVCSGLAFFTMSSLYVLEVYGLFSRITRILASVGKNPMVAYTAGNLLLIPVLRLSGLEEYLNRLNHGLGDGTLRGVIFTGIVALFTIWTTEKKWFWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP26</accession>
    <name>D7VP26_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dipeptide epimerase</fullName>
            <ecNumber evidence="5">5.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">catB</name>
        <name evidence="7" type="ORF">HMPREF0766_12746</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4 5">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the mandelate racemase/muconate lactonizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993436.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12746"/>
    <dbReference type="EnsemblBacteria" id="EFK57673">
        <property type="protein sequence ID" value="EFK57673"/>
        <property type="gene ID" value="HMPREF0766_12746"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4948">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_4_3_10"/>
    <dbReference type="OrthoDB" id="951991at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016855">
        <property type="term" value="F:racemase and epimerase activity, acting on amino acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03319">
        <property type="entry name" value="L-Ala-DL-Glu_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034603">
        <property type="entry name" value="Dipeptide_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="6">
        <location>
            <begin position="175"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for (R)-substrate epimerization" evidence="3">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for (S)-substrate epimerization" evidence="3">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR634603-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR634603-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="377" mass="42164" checksum="F149137E602DA306" modified="2010-10-05" version="1">MPESNGRKCLKNKNISSNFNTTKRPIMSTTADWIAKDFGAFKLRYRPYTLELRHVFTVASFSRSTTPVVLTELEYDGIIGYGEASMPPYLGESQESVINFLNQIDLSSFNSPFQTEEILHYVDQTMLKNTAAKAAIDIALHDLLGKILQQPFYKIWGLDAALIPPTSYTIGIDTEEMIRQKVAEADQFKILKVKLGLDTDKMIIDTIRKVTDRPLCADVNQGWKSREQALEMAHWLAERNVVFLEQPMPKEQIDDNAWLTEHSPIPTIADEACQRLADVPALKDVYTGINIKLMKCTGMREAKKMAELARALEMKVMIGCMTETSCAISAAAQLAPLVDWADLDGALLIANDIYDGMQVVDGKCILPERPGIGILKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP34</accession>
    <name>D7VP34_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma factor regulatory protein, FecR/PupR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12754</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993448.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12754"/>
    <dbReference type="EnsemblBacteria" id="EFK57681">
        <property type="protein sequence ID" value="EFK57681"/>
        <property type="gene ID" value="HMPREF0766_12754"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050192_2_3_10"/>
    <dbReference type="OrthoDB" id="1381035at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032508">
        <property type="entry name" value="FecR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16344">
        <property type="entry name" value="DUF4974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="127"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4974" evidence="3">
        <location>
            <begin position="293"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="360" mass="41448" checksum="1034A7161312A67B" modified="2010-10-05" version="1">MINTRYENVEDFLIDDTFQQYCSGENQQCIQYWETYLRHHPEQREKILQAKKLYIILVGNKKPLNVQVNKLKADIEVNSPPAENKIVRFSLWLKIAAAVVVFAGGLFWGIQRWNVQEELSSASRISYVTANGEKKTIELSDGTKVTLNAGSQLFVDNSFNKNERNVTLIGEAFFDVSKNKDKPFVLHTQDFDIRVLGTAFNVKAYPDEKTSEAVLIHGLIEMRSKRGNENSLILKPNQKVIISKADKKEETLPETAKKTKKLPLQEITIQDLQPVTAELPLADIAWKEGRLEIVDQDFSSLEHILERWYDVDIQLEGQQLNNFRFTATFSKEDIEQVLSSLQKVNPFKYKIYGKKITIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP55</accession>
    <name>D7VP55_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase, M28 family</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993477.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12775"/>
    <dbReference type="EnsemblBacteria" id="EFK57702">
        <property type="protein sequence ID" value="EFK57702"/>
        <property type="gene ID" value="HMPREF0766_12775"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019932_2_1_10"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA" evidence="2">
        <location>
            <begin position="144"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="3">
        <location>
            <begin position="307"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="552" mass="60547" checksum="2C99774AE18FA273" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPF1</accession>
    <name>D7VPF1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993652.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12871"/>
    <dbReference type="EnsemblBacteria" id="EFK57798">
        <property type="protein sequence ID" value="EFK57798"/>
        <property type="gene ID" value="HMPREF0766_12871"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3663">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094865_1_0_10"/>
    <dbReference type="OrthoDB" id="2034230at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026353">
        <property type="entry name" value="Hypoxan-DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04274">
        <property type="entry name" value="hypoxanDNAglyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="1">
        <location>
            <begin position="7"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="160" mass="18446" checksum="A4DF8B8BFAEB54BA" modified="2010-10-05" version="1">MLKESFPPVCGLSPKFLILGSLPGDKSLEQQQYYAHPQNRFWKLLFHLMEKKYESDYSKRIQLLEDHHIALWDTCASAIRPGSMDTAILSELPNDIISLLQHVTSIQHVIFNGNKAKQLYDRYHKRLSQISYHSLPSTSPANARFSFDKLVDSWSILKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPF6</accession>
    <name>D7VPF6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12876"/>
    <dbReference type="EnsemblBacteria" id="EFK57803">
        <property type="protein sequence ID" value="EFK57803"/>
        <property type="gene ID" value="HMPREF0766_12876"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_1_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="162"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="343" mass="39722" checksum="9F682F8BE2945E5A" modified="2010-10-05" version="1">MINKLNSLTSQLLWETGFRFLRHLLIFLMVSLITMNILWDEPIRILPDRYMAWIIYLLLFLTVIYINMYGLVPKLLLPGKIKKYLFAVAGLMFFFLISVGTLQNVADEDSIPLRTPPIIGILSGLATFMLFITGLTALQFFKYRLRNQQKINQLEKATMEIELANLQSQINPHFLFNMLNNANIMVEEDAKKSSEILSRFNALLQYQVEKGAAKSVTLNEEIIFLNDYLNLEKLRRDRFNFVIEPDDFVDVDLPPLLFIPFVENAVKHNPENDAFIEITFQKSGNALRFVCRNNKPKSVVVKKEGGIGLSNIQQRLNLLFEKKHSLQVLNEKDVYIVIMEIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPS3</accession>
    <name>D7VPS3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12993"/>
    <dbReference type="EnsemblBacteria" id="EFK57920">
        <property type="protein sequence ID" value="EFK57920"/>
        <property type="gene ID" value="HMPREF0766_12993"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025928_2_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024302">
        <property type="entry name" value="SusD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12741">
        <property type="entry name" value="SusD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="534" mass="59161" checksum="D767E83C683646DA" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPX1</accession>
    <name>D7VPX1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Magnesium-transporting ATPase, P-type 1</fullName>
            <ecNumber evidence="5">7.2.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mg(2+) transport ATPase, P-type 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">mgtA</name>
        <name evidence="16" type="ORF">HMPREF0766_14331</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Mediates magnesium influx to the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + Mg(2+)(out) = ADP + H(+) + Mg(2+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10260"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.14" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996452.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14331"/>
    <dbReference type="EnsemblBacteria" id="EFK57128">
        <property type="protein sequence ID" value="EFK57128"/>
        <property type="gene ID" value="HMPREF0766_14331"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_6_3_10"/>
    <dbReference type="OrthoDB" id="178322at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015444">
        <property type="term" value="F:P-type magnesium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02077">
        <property type="entry name" value="P-type_ATPase_Mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006415">
        <property type="entry name" value="P-type_ATPase_IIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01836">
        <property type="entry name" value="MGATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01524">
        <property type="entry name" value="ATPase-IIIB_Mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="770"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="805"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="835"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="871"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="15">
        <location>
            <begin position="31"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFK57128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="901" mass="100962" checksum="9933F05B5A182390" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ67</accession>
    <name>D7VQ67_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994069.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13121"/>
    <dbReference type="EnsemblBacteria" id="EFK55918">
        <property type="protein sequence ID" value="EFK55918"/>
        <property type="gene ID" value="HMPREF0766_13121"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094950_0_0_10"/>
    <dbReference type="OrthoDB" id="894718at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="301" mass="33983" checksum="E2DB99FFA7562BD7" modified="2010-10-05" version="1">MAEKIKILGVTRKSRFSPNHIGNDAAIFNEVCEKLTLTGADIEICNEDEFMEKESVPQDFIVTMARTKTLVKRLQKLEKEGKTVINSGWGIENCFRKNMTNVLLEGGIPYPASYVVSTTSDITEVFNSLKGKGVWIKRGDFHAIHKEDVTFASSAEEAKYILNEYALRGIKEAVISEHLVGDLLKFYAVKDTGFFHYFYPYEHNHHKYAVYEQINGETVHYPFDEEKLKIIADRAATILGVHIYGGDIIIGPDGNFHIIDLNDWPSFAPCRAEAADAICSLLNNVFTTQQHAKRDISIQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQT6</accession>
    <name>D7VQT6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994468.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13340"/>
    <dbReference type="EnsemblBacteria" id="EFK56137">
        <property type="protein sequence ID" value="EFK56137"/>
        <property type="gene ID" value="HMPREF0766_13340"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZAIH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071247_0_0_10"/>
    <dbReference type="OrthoDB" id="1906975at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="328" mass="37453" checksum="7E927946A84F70A6" modified="2010-10-05" version="1">MIKLEIKERFSLPEKSYILDRRSIILDNGTFVTLAEELEGVALVTLDNGHMRKVIADSSDAFENHHNMMLFAFKSQIGMVEDLSNLKLFNTDLNISAEITITGKELFSEYSMFGLTPRISGVSAIGQINNTYAIIFSEPITSQNNRYLAFLHIDFSKQTAHWQQIISLNADDYPMDRFGGFEAEEIPKEAPIIGHVISTDNKLLAFAEGSDTMSLNRYGMDFYTYGEIDSSGKLINRLLEQKGFKRDTKKHGVRGVFTSSLQYLILTPVFKSDEWKGKQKLLSIQDNKLLDIELPRGFKDFKVIEHFKEQYWLTDNRNEILCCTEVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQU2</accession>
    <name>D7VQU2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YtkA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13346"/>
    <dbReference type="EnsemblBacteria" id="EFK56143">
        <property type="protein sequence ID" value="EFK56143"/>
        <property type="gene ID" value="HMPREF0766_13346"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1561898_0_0_10"/>
    <dbReference type="OrthoDB" id="1271513at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032693">
        <property type="entry name" value="YtkA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13115">
        <property type="entry name" value="YtkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107452" description="YtkA domain-containing protein" evidence="1">
        <location>
            <begin position="37"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="YtkA" evidence="2">
        <location>
            <begin position="79"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="182" mass="19948" checksum="EDB34CCFAEF2669F" modified="2010-10-05" version="1">MILRYSNNFQNMIKNNRKAGLLAMICLLLTLTYSCGDTTKSNNLRSENKPDTVNQTIDLSNVREAKYARTLATVTKDDGRVSVSCLLPAEVKTGSNPIRFVLHNTDKNNSPELEGYSIALEPYMPAMGHGSSGNKNAEGTGEGHYRGTVQLSMPGEWLIKAKLLKDGNVVSQDSLVFPVLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR01</accession>
    <name>D7VR01_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994552.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13405"/>
    <dbReference type="EnsemblBacteria" id="EFK56202">
        <property type="protein sequence ID" value="EFK56202"/>
        <property type="gene ID" value="HMPREF0766_13405"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130980_0_0_10"/>
    <dbReference type="OrthoDB" id="1526822at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="171" mass="19748" checksum="E7A0BB6A8459E183" modified="2010-10-05" version="1">MKIITKFVIATEQDIEKLSMLAKDISTEKFSLVVEEQQLRTYLAANFNEKHLLKEVNSLSNQWLMVSVDDRPAGFARITSKGIRPDMAPRKRMIRIADFGILKVYANTTAKDSLLQKCLELCRSYDSIWIAEYVEDSLKEYFERNAFITLHNSGEHEGLLLPAVYMLREQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR63</accession>
    <name>D7VR63_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin-like_fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994633.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13467"/>
    <dbReference type="EnsemblBacteria" id="EFK56264">
        <property type="protein sequence ID" value="EFK56264"/>
        <property type="gene ID" value="HMPREF0766_13467"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_8_0_10"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13098">
        <property type="entry name" value="Thioredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107825" description="Thioredoxin-like_fold domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="2">
        <location>
            <begin position="38"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="157" mass="18000" checksum="4E21A5A3F7834696" modified="2010-10-05" version="1">MNNGSLYKVVVCAYVMLSLSVEAQLKPVPVQDITDSVQINGKPVVVLISTADCGYCYMQQKQLQNSPDILQLMTKFNYATLDAGTKENILFNKQRYRYKAQEHVHELAEYLGRDEKGRLSYPCWIVLNNKYDIIFRYQGLLAPSELNKILEKSVEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR70</accession>
    <name>D7VR70_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13474"/>
    <dbReference type="EnsemblBacteria" id="EFK56271">
        <property type="protein sequence ID" value="EFK56271"/>
        <property type="gene ID" value="HMPREF0766_13474"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3122805_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="50" mass="5873" checksum="9F7CCDB419DEAEDE" modified="2010-10-05" version="1">MLCCCVVSVLPVEEGLQEQSMWSTDKTRIEGSMFIILIWYKYNINALVWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRG8</accession>
    <name>D7VRG8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994764.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13572"/>
    <dbReference type="EnsemblBacteria" id="EFK56369">
        <property type="protein sequence ID" value="EFK56369"/>
        <property type="gene ID" value="HMPREF0766_13572"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1736873_0_0_10"/>
    <dbReference type="OrthoDB" id="1831956at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="175" mass="20939" checksum="3726109025DAEAAB" modified="2010-10-05" version="1">MKYSLLNKQDVVRKIVSGELLLKEAMVEYNIKSERTIIRWLDEYQRKQQREKEKEMSSTKDSIIYAELSCRVLPSKLLENFELIRIVEKEKALFFYLEEYEKAPRGFEKDLLIPKGFLDSIIIQDFPIRGQKSFLCLKRRKWIIDGLDKMVYSKWDDFTTLVRVTNEFGEYMKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRP5</accession>
    <name>D7VRP5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 10">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fabF</name>
        <name evidence="14" type="ORF">HMPREF0766_13649</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 10"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994913.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13649"/>
    <dbReference type="EnsemblBacteria" id="EFK56446">
        <property type="protein sequence ID" value="EFK56446"/>
        <property type="gene ID" value="HMPREF0766_13649"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_10"/>
    <dbReference type="OrthoDB" id="606297at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="13">
        <location>
            <begin position="4"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFK56446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="414" mass="44575" checksum="DF929CCEB9862BBD" modified="2010-10-05" version="1">MRRVVITGLGALTPIGNNVKKFWHSLIHGVSGAAPITKFDSSKFKTKFACELKDFDPLDYMDKAEIRKYDPFTQYALIAAEEAIKDANINFEELNRNRIGVIWGSGNGGIQTFQQQVSEFALGDGTPRFNPYFIPKMIVDIAAGMISIKYGLRGINFSTVSACATSNTAIIDAFNYIRWNKADMIITGGSEAPITESSVGGFNSAKALSTRNDAPEHASRPFDVNRDGFVMGEGAGALILEDLESAKKRGATIIAEIVGGGMAADAYHMTGTHPEGEGAYLGMLAALEDANLQPQDIGYLNTHATSTAQGDLSELRAALRVFGAESNVHISATKSMTGHLLGAAGAIEAIASIKAVQENIIPPTINSVEIEPEFKDVFDFTLAKAQQKELHYAMNNTFGFGGHIATSIFKKYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRY1</accession>
    <name>D7VRY1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter, major facilitator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_13735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995140.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13735"/>
    <dbReference type="EnsemblBacteria" id="EFK56532">
        <property type="protein sequence ID" value="EFK56532"/>
        <property type="gene ID" value="HMPREF0766_13735"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_10"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="8"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="462" mass="49410" checksum="DFA019209B4FBE47" modified="2010-10-05" version="1">MQTRKNLILILASVGTFVEALDIAIINLTIPAIQEQFGIGSDSIQWLQTLYVLFFGGFLIIGGKLSDQVGRKKIFLWGAALFMFTSLGAGLSTDFIMLAIFRALQGLGAALIMPAALSLVTNTFRETQERNRALGVFSSFAAIGSGSGLSIGGIISTYLSWHWVFLINVPILLLTLILAVFYLPADEKQSIRAKTDTVSGILLVLGLLSLTYGAHELMHIALHPVLVGGSLLLAVVLLILVFMRLRSVSEPLIDLKLFRNTSLVVSNLAFFTLGAFFIGFLFLISLMLQKDMGHTAAAAGLMLVPFSILSALVAKFVLPQISKVLNPVRMGILGWSCMFLGAVSLFASVYTGHPIVLVLLGAACISGIGMTFCFTSLSVLGIRGVDPACYGIASSLTSTSYFLGAGIGLSFMTLLSQLFPSEWVVGGLSIGILVVYALIAIGLLLYLILADQKIRQSNLALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSA6</accession>
    <name>D7VSA6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LytTr DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995448.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13860"/>
    <dbReference type="EnsemblBacteria" id="EFK56657">
        <property type="protein sequence ID" value="EFK56657"/>
        <property type="gene ID" value="HMPREF0766_13860"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_14_1_10"/>
    <dbReference type="OrthoDB" id="1958442at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="132"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="232" mass="27243" checksum="90ECF3415F674807" modified="2010-10-05" version="1">MKRKINCLILDDEPFAVNLLADYASKVSQLNVIYAGSDAFEVIEILNSESVDLIFIDIQMPQLTGIELMQMFNQKHNFIITSAYSEYALDAFQFNVIDFLLKPITFNRFYQSVEKFNRWQDTFQSSESDNSLFVKADRKHYKIQPEDILYIEGLKDYIRIHTVSERMVVLENMKDILDRLPQHQFVRIHRSYIVPLKRIKVIEGSQIVMTNGEYLPIGETYRKLIGEWLGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSC8</accession>
    <name>D7VSC8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995494.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13882"/>
    <dbReference type="EnsemblBacteria" id="EFK56679">
        <property type="protein sequence ID" value="EFK56679"/>
        <property type="gene ID" value="HMPREF0766_13882"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030V8J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1427183_0_0_10"/>
    <dbReference type="OrthoDB" id="1749373at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="190" mass="21892" checksum="14B97D8C8DC12518" modified="2010-10-05" version="1">MKNSMLKIYGIISLLLLMDILAYCFFKISLRGYYSDVVLVWLWFTGSFTIIILFWKRILAKILLGAITGGLILSILPMAMPFYALLFSNTPFGLWLDTDLNANYRAQIVGYSVMSHPVLQVIEKKGLLEKQIFQCNDRDLLNDNYEVKIRYAKDIIFERETDNTLTLTLFYGGSNKTLTFDKSTGKIIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSG0</accession>
    <name>D7VSG0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sigma factor regulatory protein, FecR/PupR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13914"/>
    <dbReference type="EnsemblBacteria" id="EFK56711">
        <property type="protein sequence ID" value="EFK56711"/>
        <property type="gene ID" value="HMPREF0766_13914"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050192_1_0_10"/>
    <dbReference type="OrthoDB" id="1381035at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="186"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="391" mass="44862" checksum="A756EFA005EFEFD3" modified="2010-10-05" version="1">MSLTLYNQSADQTVRHKIMTDKNKIRAIISRIHKGDYSDEDLLQYNAWCNRQQDVDEESDLSDKSEQIFRSVKKRINGRKHRNIVVRTAAVAASVLFFFLLQLLLKNDKNIDSGGSIAMIHEHQIPKGFRKAVLTLSDGDTIDLIKDRAQNRFIQDNSITSVSPDNIVRIYDTQSDTDRMEVSYNTLATSRGQQFKIILSDGTKVWLNAASSIRYPLSFSHQKERKVELMGEAYFEVTKSEQQPFIVTSRNQQVKVLGTHFNINSYPDEPLVKTTLLEGAVEVNQEIVLKPGEQSQVDKTNYASKIRVDPEIVTSWKNGYFEFRNENIYEIMRKVVRFHDIQVAYEGIIPLDGMSGQIRMEDDIVKILDILGSTSLLKITQDDNRVNICKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSR9</accession>
    <name>D7VSR9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD dependent oxidoreductase</fullName>
            <ecNumber evidence="8">1.1.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glpD</name>
        <name evidence="8" type="ORF">HMPREF0766_14023</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995746.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14023"/>
    <dbReference type="EnsemblBacteria" id="EFK56820">
        <property type="protein sequence ID" value="EFK56820"/>
        <property type="gene ID" value="HMPREF0766_14023"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0578">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015740_4_1_10"/>
    <dbReference type="OrthoDB" id="360065at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052591">
        <property type="term" value="F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="6">
        <location>
            <begin position="19"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="DAO_C" evidence="7">
        <location>
            <begin position="415"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK56820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="522" mass="58034" checksum="83F43F73A257DBC4" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT82</accession>
    <name>D7VT82_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma factor regulatory protein, FecR/PupR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_14186</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996112.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14186"/>
    <dbReference type="EnsemblBacteria" id="EFK56983">
        <property type="protein sequence ID" value="EFK56983"/>
        <property type="gene ID" value="HMPREF0766_14186"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050192_1_0_10"/>
    <dbReference type="OrthoDB" id="1381035at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032508">
        <property type="entry name" value="FecR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16344">
        <property type="entry name" value="DUF4974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="179"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4974" evidence="3">
        <location>
            <begin position="315"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="387" mass="43950" checksum="5A609305982CADFB" modified="2010-10-05" version="1">MKQKPEPQRLQYLAEKWLNGTISAAEKQEFDEWYFSFEDHIVTDHTAEELDAVASDLYKNIQLRAGMTVPPRNKKIYPSRRILYWAASVLILISAGIILYLRQENVQHQYAKTAVIVPGSSKGNLQMGDGNAYDLEQLDTGIFLKRNGVEIVKTRQGEINYTVRSIEALNSHEIVDNSVSTPNGGQYQIQLSDGTRIWLNAASAIRFPIAFVGDKRIVELQGEAYFEVAKDARKPFIVKTGKEEVRVLGTHFNVNSYDGESVSRVSLLEGKVEVLAKQGLYKTHLTPGQQTVNTAKSLTVESFNMEESIAWKNGEFIFNNERLDQVMLKVGRWYDADITVDPEIAKILIWGSISKSEQIDKVLKLIQLTNENIKYRIEGRRIYMSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTB2</accession>
    <name>D7VTB2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA modification GTPase MnmE</fullName>
            <ecNumber evidence="6">3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mnmE</name>
        <name evidence="6" type="synonym">trmE</name>
        <name evidence="9" type="ORF">HMPREF0766_14216</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996199.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14216"/>
    <dbReference type="EnsemblBacteria" id="EFK57013">
        <property type="protein sequence ID" value="EFK57013"/>
        <property type="gene ID" value="HMPREF0766_14216"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019624_4_1_10"/>
    <dbReference type="OrthoDB" id="263682at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TrmE-type G" evidence="8">
        <location>
            <begin position="223"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="233"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="252"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="277"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK57013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="458" mass="50833" checksum="670B4424F15D8BEE" modified="2010-10-05" version="1">MSTSSIQQQETIVALATANGNGAIAVIRLSGKDAIEIANQVFRGKDLSAQPSHTVHFGTIRDGEEILDEVLVTLFVGPNSYTKEHVVEISTHNSKYIIERIISLLIRKGARAAKPGEFTLRAFLNGGMDLSQAEAVADLIASNSAASHQIAMQQMRGGFSNQLRRLRDDLIHFASLIELELDFSEEDVEFANRDQLKQLILQINSVVRKLIQSFEQGNVLKNGVPVVIAGKPNVGKSTLLNALLNEERAIVSDIAGTTRDTIEDEINIHGVTFRFIDTAGIRETVDVIEAKGVERTREKMKQARLIIYLFDPVQDTIADVETQLEEVRSLNIPFVTIINKSDLLTEEQRAEYRTLSPVFISAKEQIGVEELKDELLRQVNLANLNTDDVMVTNIRHVEALQHTEDSLSRVLFGIDNPVTSDFLAMDIRQALYHLGEITGSVSTDDLLDNIFSKFCIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTC8</accession>
    <name>D7VTC8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidinol dehydrogenase</fullName>
            <shortName evidence="4">HDH</shortName>
            <ecNumber evidence="4">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 11" type="primary">hisD</name>
        <name evidence="11" type="ORF">HMPREF0766_14232</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5 10">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996251.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14232"/>
    <dbReference type="EnsemblBacteria" id="EFK57029">
        <property type="protein sequence ID" value="EFK57029"/>
        <property type="gene ID" value="HMPREF0766_14232"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006732_3_0_10"/>
    <dbReference type="OrthoDB" id="935289at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="1 4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 9" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="4 6">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4 6">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 8">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 8">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK57029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="428" mass="46795" checksum="1B781C6EEEFA2D87" modified="2010-10-05" version="1">MLKKYNYSQLSSQDIADLVDRNTDPSSAIQDTVLHIIDEVRRHGDRALVDYAHQFDKVKLDKLYLDADDIDELAFTINREQQRALEIAFQNIHKFHSYQLKRERVVETMPGVKCWREPRPIEKVGLYIPGGSAVLPSTLLMLGVPARIAGCKEIVVCSPPQASGKINGFVAYCLKLLNIKRIYLVGGAQAVAAMAFGTESIPKVDKIFGPGNQFVTKAKSMLQGMTNVSIDMPAGPSEVLVLADETANPAYIAADLLAQAEHGVDSQAVLVATSDTLIDEVNKQLDEQLAVLPRKEMAQKALENSYAILVSDLTEGMKFSNAYAPEHLIIESDQWKSMSNQILNAGSVFLGHLTPESAGDYASGTNHTLPTSGYARSYSGVSVDSFVKKITFQHISEEGLLQIGSTVEILAELEGLHAHKNAVSIRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTD1</accession>
    <name>D7VTD1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996259.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14235"/>
    <dbReference type="EnsemblBacteria" id="EFK57032">
        <property type="protein sequence ID" value="EFK57032"/>
        <property type="gene ID" value="HMPREF0766_14235"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_956151_0_0_10"/>
    <dbReference type="OrthoDB" id="1629654at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="291" mass="33414" checksum="B35B91230802DAA9" modified="2010-10-05" version="1">MEVAEDIKWIKNVKRNNCEGWAYENAKVGNNFYLNWPTKMRGSAETPKTGEVIVLFQKPNFINGQRNRLVHLTHLVVPVSEDIHVDENSLKHRWCREVKLLAKAKPIQTIPNPGYYNSFKPNRGLTNPIINLENRENLTEDEVKVDLWELFGGFFSDSLSSENLYGRLPAHMYEGSEGDKIVRAHILQELTRRNPAIVRRAKEEALKRGNGRIRCECCGFDFVAAYGPLGDRFIECHHKIHLNKGALHCLRFPYTSNGGPFTLYAPLNMPDKNLQTNSQNILSSFRCLPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTG4</accession>
    <name>D7VTG4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996343.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14268"/>
    <dbReference type="EnsemblBacteria" id="EFK57065">
        <property type="protein sequence ID" value="EFK57065"/>
        <property type="gene ID" value="HMPREF0766_14268"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062440_3_1_10"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="37"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="254" mass="28526" checksum="C2F575960FE9DA8B" modified="2010-10-05" version="1">MDNKHYGAGYLVDTGDFLKQLKIHSYTPFANLQQGVILDLGCGTGMDAINIADMVGERGQVIGIDHDQAMIGHARTTVGERKNIDFVQAGVDKLDFEDNSVSGIRMERVVQHLPEPDATFREVYRVLKTDHPFVVVETIWDSLNFYTQHIATEQKIRNYLTGQKVNNGWAGNKLTADLNANGFRNIQLDTFCMVVRTKEEANRYVFLDLILAEMVDKSVLTKEESEDFINSLLSADNNGYFTVSMNLVIAKAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTS2</accession>
    <name>D7VTS2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002200.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14392"/>
    <dbReference type="EnsemblBacteria" id="EFK55701">
        <property type="protein sequence ID" value="EFK55701"/>
        <property type="gene ID" value="HMPREF0766_14392"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133146_0_0_10"/>
    <dbReference type="OrthoDB" id="2075088at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009325">
        <property type="entry name" value="DUF983"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06170">
        <property type="entry name" value="DUF983"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="134" mass="15441" checksum="EDFB78FDA4DAA600" modified="2010-10-05" version="1">MATSKFSALTHSKCPRCRVGKVFEGKAYGFRKQKMNEFCPVCGVKFEVEPGYFYAAMYVSYAFSVAQIVSLAVATYIITRSESPWLYLGVLFFTTLVFAPFNFRYSRLVLLHYMTPKISYNPRYEEEAADVEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTW6</accession>
    <name>D7VTW6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal bacterial protein YeaZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yeaZ</name>
        <name evidence="2" type="ORF">HMPREF0766_14436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002282.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14436"/>
    <dbReference type="EnsemblBacteria" id="EFK55745">
        <property type="protein sequence ID" value="EFK55745"/>
        <property type="gene ID" value="HMPREF0766_14436"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064886_1_0_10"/>
    <dbReference type="OrthoDB" id="1826274at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="38"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="233" mass="25674" checksum="DCAF58D3DD3D621B" modified="2010-10-05" version="1">MNKNYILQIETATPACSVAVSLDGDVITTVGAEENNIHATHLTVFIEKALQDAGISVRDLATIAVSMGPGSYTGLRIGVSAAKGLCYALDIPLIAIDTLSAMFCGFSKRIIQENEKVLLCPMIDARRMEVYSALYDKQGHQVVPVGANIIDQDFFHAYEEEGYQLHLFGSGAPKFNTLFEANPLIHVYDDFSNSAAHMTVQAFEKLNSQSFEDVAYFEPYYLKDFIATTPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTX5</accession>
    <name>D7VTX5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Cell division protein FtsA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">ftsA</name>
        <name evidence="9" type="ORF">HMPREF0766_14445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Self-interacts. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="5">Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002291.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14445"/>
    <dbReference type="EnsemblBacteria" id="EFK55754">
        <property type="protein sequence ID" value="EFK55754"/>
        <property type="gene ID" value="HMPREF0766_14445"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0849">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037850_4_1_10"/>
    <dbReference type="OrthoDB" id="1044637at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02033">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020823">
        <property type="entry name" value="Cell_div_FtsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003494">
        <property type="entry name" value="SHS2_FtsA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02491">
        <property type="entry name" value="SHS2_FTSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003101">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00842">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01174">
        <property type="entry name" value="ftsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsA" evidence="8">
        <location>
            <begin position="15"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR003101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK55754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="458" mass="50031" checksum="5F963937F76F51F5" modified="2010-10-05" version="1">MKPRITDSEKENPIIVGLDIGTTKICVTVGRRSGTNKIELLGVGKAESAGVNRGVVANIQKTVTSIKEAVALAEGLSNVDIKVVNVGIAGQHIKSIQHRGILTKNDDDEVGRRDIERLISDMYKLVLPPGEEIIHVLPQEFTIDNEPGIKEPVGMAGRRIEANFHIISGRVTDIKNIKRCVDYSSLEVSSLVLEPLASSEAVLDEDEKNAGVVLVDIGGGTTDVAIFHEGIIRHTAVIPLGGNIVTEDIRQGCSVLRNQAELLKVRYGSALADENKENEVICVPGIRGREAKEISVKNLAYIIQARMEEIIEHVYYEIKSSGYEDKLIGGIVVTGGGAQLKHLVQLVEYITGIDCRIGYPNEYLAKTDLLNKQLFDELKSPLYATGIGLLIKGIQAIEDEEASEHEDSIKRTPKTASAPGVKDIAEKQQKKEGWLKKFLTEFIKDDAGIDDDTFIGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D7VG87</accession>
    <name>D7VG87_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">map</name>
        <name evidence="5" type="ORF">HMPREF0766_10006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001822.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10006"/>
    <dbReference type="EnsemblBacteria" id="EFK60062">
        <property type="protein sequence ID" value="EFK60062"/>
        <property type="gene ID" value="HMPREF0766_10006"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_0_2_10"/>
    <dbReference type="OrthoDB" id="1285136at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="11"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK60062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="250" mass="27236" checksum="AD73937B3E7EC133" modified="2010-10-05" version="1">MIISDDNELKKMKAVSQAVAVTLLKMQQFARPGISTQELDEFGGDILSEFGARSAPRLTYGFPGYTCISLNNEVAHGIPSPGRILRDGDLINIDVSAELDGYWSDNGGSIVVGEDLHGHTPLVDASKNILLSAISRIKGGVRINEIGHYIETEARKRGYLVIKNLGGHGLGKALHEEPFDLLNYKDPDDKRRFRKGTVVAIETFINTQSTLAIEQADGFTLLGNKGGFAVQHEHTLVVTDEKPIILTAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGE6</accession>
    <name>D7VGE6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10065"/>
    <dbReference type="EnsemblBacteria" id="EFK60121">
        <property type="protein sequence ID" value="EFK60121"/>
        <property type="gene ID" value="HMPREF0766_10065"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3157944_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK60121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="48" mass="5546" checksum="63C03CCCA4690E36" modified="2010-10-05" version="1">MLKYTIFSLLLVSCNFTEKGKIRKNDINQSDVSVISNHLFMEKQGKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGF4</accession>
    <name>D7VGF4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002004.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10073"/>
    <dbReference type="EnsemblBacteria" id="EFK60129">
        <property type="protein sequence ID" value="EFK60129"/>
        <property type="gene ID" value="HMPREF0766_10073"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8F9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076073_0_0_10"/>
    <dbReference type="OrthoDB" id="1972507at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK60129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="252" mass="27220" checksum="322E577C3CC7A77C" modified="2010-10-05" version="1">MARQKGIIKLKGTIGDITFYKSEDGYLAREKGGIDGSRIANDPAFQRTRENGAEFGRARKAGKLLRTALRPLLLSSTDSRMVGRLTQSMMKVIQADTVSVRGLRNVIDGEAELLTGFEFNIRGALSTSMFAPYAIETDRVAGKVKLGIGGFVPANMIAAPVGATHFRIVSGIALVDFEGEAFEAKFLETAVMPWNNVAIADIAQEHDFTPGSKKPLFVVLGVAFYQQINGEMYLLKNGAFNALSIVKVDGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGM6</accession>
    <name>D7VGM6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_10145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996703.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10145"/>
    <dbReference type="EnsemblBacteria" id="EFK59228">
        <property type="protein sequence ID" value="EFK59228"/>
        <property type="gene ID" value="HMPREF0766_10145"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_10"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="252" mass="27423" checksum="2B2D61F0EAFB69B0" modified="2010-10-05" version="1">MADNTLIQITDIGRKYIIGSETIHALNSVSLSIKKGEFVALMGPSGSGKSTLMNILGCLDTPSKGEYVLNGINVSQMTENELAEVRNKEIGFVFQTFNLLPKSTALENVALPLIYAGKSKKVRDEKALATLTSVGLEHRTDHKPNELSGGQRQRVAVARALINDPSIILADEPTGNLDTKTSIEIMGLLEDIHAKGNTIILVTHEEDIAQHAHRIVRMRDGLIEDDYPNTNIKSVSPRLAALNAKGSDFENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH12</accession>
    <name>D7VH12_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997079.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10281"/>
    <dbReference type="EnsemblBacteria" id="EFK59364">
        <property type="protein sequence ID" value="EFK59364"/>
        <property type="gene ID" value="HMPREF0766_10281"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025928_1_0_10"/>
    <dbReference type="OrthoDB" id="377914at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041662">
        <property type="entry name" value="SusD-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12771">
        <property type="entry name" value="SusD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="537" mass="61463" checksum="53B9B55B1E7C54E8" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH18</accession>
    <name>D7VH18_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997092.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10287"/>
    <dbReference type="EnsemblBacteria" id="EFK59370">
        <property type="protein sequence ID" value="EFK59370"/>
        <property type="gene ID" value="HMPREF0766_10287"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025928_1_0_10"/>
    <dbReference type="OrthoDB" id="319098at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041662">
        <property type="entry name" value="SusD-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12771">
        <property type="entry name" value="SusD-like_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="563" mass="63149" checksum="2D8A79C4744437F7" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH23</accession>
    <name>D7VH23_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal-phosphate dependent protein</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cysK2</name>
        <name evidence="4" type="ORF">HMPREF0766_10292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997104.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10292"/>
    <dbReference type="EnsemblBacteria" id="EFK59375">
        <property type="protein sequence ID" value="EFK59375"/>
        <property type="gene ID" value="HMPREF0766_10292"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_10"/>
    <dbReference type="OrthoDB" id="1033353at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="23"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="362" mass="39574" checksum="EEE079C11D479569" modified="2010-10-05" version="1">MKLKSISECLSPELDSRFTHLWHLVGNTPMLELHYTYKGKQDKIYVKCENYNLTGSIKDRMALYILYKAYMNCQIRPDDVIVEATSGNTGIAFSAIGKALGHQVKIIMPDWLSKERIDIIKSMGADIQLVSKEEGGFLGSIRISEELAAGGGVFLPRQFENQFNAEAHELTTGREIALQLSSLGLVADAFVAGVGTGGTVMGVGNYLRVQNPNVRIHPLEPAESPTLSTGHKVGSHRIQGISDEFIPAIVKLDSLDNVINACDGDAIIMAQKLARELGLAVGISSGANVIGAIKLKEEMGRDATVVTLLCDDNKKYLSTDLVRNEPVKEGYISTDLSFTGFHPVCRLEKPLFGNTLKEYNNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH86</accession>
    <name>D7VH86_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trypsin</fullName>
            <ecNumber evidence="4">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10355"/>
    <dbReference type="EnsemblBacteria" id="EFK59438">
        <property type="protein sequence ID" value="EFK59438"/>
        <property type="gene ID" value="HMPREF0766_10355"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_760100_0_0_10"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="123"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="370" mass="41274" checksum="C202FCD94DE8B32C" modified="2010-10-05" version="1">MAMMSQQEFYDLADRYLRNEMTTEERVSFEAFCAENPTFSIQLQQHRIFISDMQSVAARMDFKNQLKNVSASYHRSHKHKTQTKETPVVPIQARFKLNIAVAAAVAIISVFSTLWMSGYYTNLEKASTDYSALRRDMNNVKRNVNEHNAALRNIDTKKKDINNKVDSHYGATGFMVTKDGYVVTNFHVINGADSIHLQNNKGDSFRASVIYTDAAKDLAILHINDSNFRKLKSIPYTFKSRSSDLGEDIYTIGFPRDEAVYGQGYLSSATGYAGDTIAYQISIPVNPGNSGGPVLDNKGNIIGIISGKQTGLDGAGFAIKTKILLDALNEIPANSLNGDIVLNKKNSLSNLSRTDQIKQLQDYIYMVKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH87</accession>
    <name>D7VH87_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TPM_phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_10356</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997237.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10356"/>
    <dbReference type="EnsemblBacteria" id="EFK59439">
        <property type="protein sequence ID" value="EFK59439"/>
        <property type="gene ID" value="HMPREF0766_10356"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035211_4_0_10"/>
    <dbReference type="OrthoDB" id="1720318at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="TPM_phosphatase" evidence="6">
        <location>
            <begin position="53"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="465"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="504" mass="55954" checksum="1F5806ED998E2335" modified="2010-10-05" version="1">MKNNKSMIRVLFYTIYCIVIHAFLLFGSLTAQAQYTVEEIPNPKENGQNYYVSNPNGILSSAAESEINQMAVEIEEKTKAEVAVVVVSDFEGDDDFAFVHRLFNTWGIGKKEANNGLLLFIGTDRHYYRFVTGYGMEALLPDAYLKRVGESFLVPHFRNSDYDAGVIAAMQAIKQSLLAPDSVKELDSILKRNNSFWFKHAELLNKTGIILLIVLIVYLYLGWITKSLSGRVKIKKGLHPVVSGCGCFGILIFFSVFIFAFGFNNLEEVFKLKNLPIFLAILGSLILAMKYNQSRTLISDSYQDDESKSTALSKFSTRTLLIPLIAPLAFFDLFAVSKFRNKVKVRFIPPDESGQWKRINKDEISAKELTKYLNDGQRNEQKVNSKIFEFWKNTLSGKIQVNSFDGEEASSYEECPQCHFFTFHIPYIKTITAATYSNSGTGIEKQDCRNCRYEIELGKVTIPKKVRSSSSGSSGSSGSSGSSGSSGGSFGGGSSGGGGAGGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHA8</accession>
    <name>D7VHA8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997283.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK59460">
        <property type="protein sequence ID" value="EFK59460"/>
        <property type="gene ID" value="HMPREF0766_10377"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032WSN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154568_0_0_10"/>
    <dbReference type="OrthoDB" id="2042070at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="134" mass="15358" checksum="934C8E96114D9903" modified="2010-10-05" version="1">MLIIRKNFALAGVILCLLSGMLPMLKVPIKGNWNLYQTDEALFFITYGIIGITGLLFFIRQLKGYRLMTRIAAGWYLLSISAVYFKINNYFGWKFADGLLSKAIHMRWGWIVYLIGILCLLISTKQLKQAEQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHF8</accession>
    <name>D7VHF8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997417.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10427"/>
    <dbReference type="EnsemblBacteria" id="EFK59510">
        <property type="protein sequence ID" value="EFK59510"/>
        <property type="gene ID" value="HMPREF0766_10427"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7J4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_798888_0_0_10"/>
    <dbReference type="OrthoDB" id="438227at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="347" mass="41339" checksum="CA5F0BF7A8AC4249" modified="2010-10-05" version="1">MEYDDVKISRKKPIFPVGSGLHKYLKMYQRDGKLPIAYKDLLTFTETVPVMDKYGNDTFWETPLYPPYLQDQLYEGLKIIYAQLKASGNTRIVQHKYIDRIEYCAFGNTRPFRIRIVNRLNDVYDYFYIKQADASRIYGLELEEILSPNQVNYLVDHETLVEEHIVGIPGDVFTKSRMYSPDYNMTRIAKEFVKFNERCIITLLGDMRAYNFVMQITPDFDDFQFRIRAIDFDQQFYEGNPKVYMPQFFKENFPYVKICMDYLNDRTVSQYQQEERSSIVHRVRSERHRIADLRDASKTQQLSSVENINRLKEGYAEFHDNKQYLKCNSMTDIIELNVKNVIRQVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHG4</accession>
    <name>D7VHG4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase, class III</fullName>
            <ecNumber evidence="3">2.6.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">argD2</name>
        <name evidence="3" type="ORF">HMPREF0766_10433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997437.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10433"/>
    <dbReference type="EnsemblBacteria" id="EFK59516">
        <property type="protein sequence ID" value="EFK59516"/>
        <property type="gene ID" value="HMPREF0766_10433"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4992">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_1_10"/>
    <dbReference type="OrthoDB" id="572533at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="378" mass="41377" checksum="6038763A37364C1E" modified="2010-10-05" version="1">MDLFNVYPINPINIVKAKGSTVWDAAGNAYLDLYGGHAVISIGHTHPHYVRRLTDQLNEIGFYSNSVEIPIQKELARLLGELSGKSDYHLFLCNSGAEANENALKLASFYNKRKKVISFTKAFHGRTSLAVAATDNPNIVAPVNETDNVVFLPFNDEEALQQAFDSYGDEISSVIIEGIQGVGGIQEASVPFLRLIRSLCDQHNAVFIADAVQCGYGRTGSFYSHDYAGIDADIYTMAKGMGNGFPIGAISIAPKFKAVFGMLGTTFGGNHLACAAAVAVLEVIKQDNLLKNAEEVGQYLITELKKIDRIKEVRGRGLMIGIDLPEDLSTLKKELLEKEKIFTGEAKPNVIRLLPALNITKAHADQFLEAFDRRLKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHH9</accession>
    <name>D7VHH9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpsN</name>
        <name evidence="5" type="ORF">HMPREF0766_10448</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997479.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10448"/>
    <dbReference type="EnsemblBacteria" id="EFK59531">
        <property type="protein sequence ID" value="EFK59531"/>
        <property type="gene ID" value="HMPREF0766_10448"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139869_0_0_10"/>
    <dbReference type="OrthoDB" id="2032609at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00537">
        <property type="entry name" value="Ribosomal_S14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023036">
        <property type="entry name" value="Ribosomal_S14_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="89" mass="9958" checksum="D96C61FEED6E73C9" modified="2010-10-05" version="1">MAKEGLKAREVKRAKLVAKYADKRAALKAAGDYEALDKLPKNASPVRLHNRCKLTGRPKGYMRQFGISRVTFREMALDGKIPGVKKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHP5</accession>
    <name>D7VHP5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase, alpha/beta domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menH</name>
        <name evidence="3" type="ORF">HMPREF0766_10514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997602.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10514"/>
    <dbReference type="EnsemblBacteria" id="EFK59597">
        <property type="protein sequence ID" value="EFK59597"/>
        <property type="gene ID" value="HMPREF0766_10514"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_760546_0_0_10"/>
    <dbReference type="OrthoDB" id="1498437at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107482" evidence="1">
        <location>
            <begin position="26"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="70"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="363" mass="41304" checksum="DD899A0BFED501A1" modified="2010-10-05" version="1">MSSQICLKPLLLFMALICAHLVATAQQQTGLSSYTQAHQLYTAYEARHGNYIQTPNVRLHYLSWGDPKNPAVVWLHGSLTNAYELMSIAPQLADAGYFVIAIDYYGHGQTPIPAHEVSLYHAADDVHFLLNELNISKAYIGGFSRGAYIATAFYDSYPSSVRGLILEEGGTVAFNSYFHRLSDATLDSLIQKQTALSAQSNPYLQEFDSQQAAFDFLKDSTDQSSQFELLSWISRNKQDKWIIYKDLEPFLGLSTAEDFKNIVLRPSKSPMFARSVTSIDPMIIYRNLSVPVLLMEACSDTDPLPFDEENRIFTKQFKPWVTHKRYPGIEHNIHFEQPKLFTKDIIEFLNQHYHDDQRSTGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHZ8</accession>
    <name>D7VHZ8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F5/8 type C domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997866.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10617"/>
    <dbReference type="EnsemblBacteria" id="EFK59700">
        <property type="protein sequence ID" value="EFK59700"/>
        <property type="gene ID" value="HMPREF0766_10617"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_391128_0_0_10"/>
    <dbReference type="OrthoDB" id="464410at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035423">
        <property type="entry name" value="M60-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042279">
        <property type="entry name" value="Pep_M60_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031161">
        <property type="entry name" value="Peptidase_M60_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17291">
        <property type="entry name" value="M60-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13402">
        <property type="entry name" value="Peptidase_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01276">
        <property type="entry name" value="M60-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51723">
        <property type="entry name" value="PEPTIDASE_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M60" evidence="2">
        <location>
            <begin position="105"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="517"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="675" mass="76094" checksum="FB9667035E5E0A13" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI25</accession>
    <name>D7VI25_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997919.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10644"/>
    <dbReference type="EnsemblBacteria" id="EFK59727">
        <property type="protein sequence ID" value="EFK59727"/>
        <property type="gene ID" value="HMPREF0766_10644"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZD9S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115785_0_0_10"/>
    <dbReference type="OrthoDB" id="1478929at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="193" mass="22576" checksum="C2D471B7C3D42667" modified="2010-10-05" version="1">MSLHQDPELKKAVLTLPQKEKDKLLVRLISKDKMLIKQLHYQLLEDENDLEDRITHLRAQLQQLFDTGTSQVGGSPNFSNFTGLNRLVKQASGMVNEHEKVTKDKVSEVEFRIYILRRAIEGYPELFQSSYQSAAHKLHKYISGRLKHVLTKYDKLHEDLQFDFREDLQRILDVATKSALHSYMRDLKLQTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI92</accession>
    <name>D7VI92_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S23 ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998053.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10711"/>
    <dbReference type="EnsemblBacteria" id="EFK59794">
        <property type="protein sequence ID" value="EFK59794"/>
        <property type="gene ID" value="HMPREF0766_10711"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129874_0_6_10"/>
    <dbReference type="OrthoDB" id="2023580at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="117" mass="13258" checksum="15F9EA69FD894D85" modified="2010-10-05" version="1">MASHKDLKVWQESMDLVMLIYEIVAVFPKDELFGLTSQIKRAAISIPSNIAEGAGRQSNAEYIRFLYIALGSVSELETQLEIAFRLGFINDVDMYNSKVHFIKSMLSNLIKNLKSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIE2</accession>
    <name>D7VIE2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10761"/>
    <dbReference type="EnsemblBacteria" id="EFK59844">
        <property type="protein sequence ID" value="EFK59844"/>
        <property type="gene ID" value="HMPREF0766_10761"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3173338_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="47" mass="5549" checksum="045B3002964E724D" modified="2010-10-05" version="1">MLFRKKKVAKTILEEPDDQPAGYAIYWTILIAVVILAILYFVFFKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIG0</accession>
    <name>D7VIG0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998187.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10779"/>
    <dbReference type="EnsemblBacteria" id="EFK59862">
        <property type="protein sequence ID" value="EFK59862"/>
        <property type="gene ID" value="HMPREF0766_10779"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1633309_0_0_10"/>
    <dbReference type="OrthoDB" id="1471186at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037079">
        <property type="entry name" value="AF2212/PG0164-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015018">
        <property type="entry name" value="DUF1905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08922">
        <property type="entry name" value="DUF1905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="163" mass="18263" checksum="3B3F111BC6634973" modified="2010-10-05" version="1">MHFTAVIDKIGINPFVFVPELVLLELITAAGQHKGKIPVSLTIEGIVFTQTLVKYAGEWRLYINGPMLKATGKTVGDTADFTLEFNAEKPEIQIHPLLAKALQQNVEAYTVFQSLSPSLQLEIVRYISHLKQEDSIARNVGKAIQFLLGKERFIGREPIKKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIL1</accession>
    <name>D7VIL1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the XseB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998285.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10830"/>
    <dbReference type="EnsemblBacteria" id="EFK59913">
        <property type="protein sequence ID" value="EFK59913"/>
        <property type="gene ID" value="HMPREF0766_10830"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1722">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145918_4_1_10"/>
    <dbReference type="OrthoDB" id="2057189at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="75" mass="8328" checksum="AD1E3EE5698093E2" modified="2010-10-05" version="1">METNYSYTDAFNELQQIVNDISSGSTNIDELSEKIKRAALLIKICRTKLTSTEEEVNQLLANLAPAEAPANPEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIR6</accession>
    <name>D7VIR6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S12 methylthiotransferase RimO</fullName>
            <shortName evidence="7">S12 MTTase</shortName>
            <shortName evidence="7">S12 methylthiotransferase</shortName>
            <ecNumber evidence="7">2.8.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ribosome maturation factor RimO</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">rimO</name>
        <name evidence="11" type="ORF">HMPREF0766_10885</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37087"/>
            <dbReference type="Rhea" id="RHEA-COMP:10460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10461"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:73599"/>
            <dbReference type="EC" id="2.8.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the methylthiotransferase family. RimO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.4" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10885"/>
    <dbReference type="EnsemblBacteria" id="EFK59968">
        <property type="protein sequence ID" value="EFK59968"/>
        <property type="gene ID" value="HMPREF0766_10885"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_0_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103039">
        <property type="term" value="F:protein methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018339">
        <property type="term" value="P:peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01865">
        <property type="entry name" value="MTTase_RimO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041582">
        <property type="entry name" value="RimO_TRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18693">
        <property type="entry name" value="TRAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00274">
        <property type="entry name" value="ribosomal_protein_S12_methylth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01125">
        <property type="entry name" value="TIGR01125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="9">
        <location>
            <begin position="26"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="155"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="8">
        <location>
            <begin position="388"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK59968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="455" mass="51883" checksum="E1E2D17EBC147E21" modified="2010-10-05" version="1">MILYSKNLQGNMKTKSVRSAEIKQKPRVNVITLGCSKNIHDSEVLMGQLKGNQMEVVHEASNIQNNDIVVINTCGFIDNAKQESIDTILQYSELKEQGKINKVIVTGCLSERYKPELQAEISSVDAYFGTNDLPELLSSIGADYRHELLGERMLSTPLHFSYFKIAEGCNRPCSFCAIPLMRGKHVSKPMEDLVKEAKFLASNGTKELILIAQDLTYYGLDIYGKRNLSDLLRNLSDVDGIEWIRLQYAYPSGFPMDILDAMAERSNICNYLDMPLQHISDNMLKSMRRGTTKQKQIDLVNQIRDKVPDIALRTTLICGYPGETEQDFQEMLEWVEESRFDRLGCFTYSHEEKTHAYSLTDDVPEEVKESRVEQIMEVQQGISYDINQEKIGKTYKVLVDKVDGDYFIGRTEYDSPEVDNEVLISAKDTYARIGDFVQVKIDRAEDFDLYGTIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIR7</accession>
    <name>D7VIR7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">ftsY</name>
        <name evidence="7" type="ORF">HMPREF0766_10886</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998405.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10886"/>
    <dbReference type="EnsemblBacteria" id="EFK59969">
        <property type="protein sequence ID" value="EFK59969"/>
        <property type="gene ID" value="HMPREF0766_10886"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_3_4_10"/>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="6">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="126"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="208"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="272"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="324" mass="34992" checksum="6720D2C8E7C15923" modified="2010-10-05" version="1">MGLFDFFKKKQETPEAQEALDKGLEKTKEGFLSKITKAVVGKSTVDDDVLDELEEILVTSDVGVTTTLKIIDRIQARVAKDKYINTSELNNLLKDEIQALLAENNSSDFENFEYGNHKPYVIMVVGVNGVGKTTTIGKLAHQLKAAGNKVVLGAADTFRAAAVDQLKLWGERVGVRVVAQAMGSDPASVAFDTIKSAVSNGDDVAIIDTAGRLHNKVGLMNELGKIKNVMQKVIPGAPHEILLVLDASTGQNAIEQCTQFTQATDVNALALTKLDGTAKGGVVIGISDQFKIPVKYIGVGEKIDDLQLFNKKEFVDSLFKESAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIR9</accession>
    <name>D7VIR9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpmG</name>
        <name evidence="5" type="ORF">HMPREF0766_10888</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998409.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10888"/>
    <dbReference type="EnsemblBacteria" id="EFK59971">
        <property type="protein sequence ID" value="EFK59971"/>
        <property type="gene ID" value="HMPREF0766_10888"/>
    </dbReference>
    <dbReference type="GeneID" id="66690022"/>
    <dbReference type="eggNOG" id="COG0267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190949_3_0_10"/>
    <dbReference type="OrthoDB" id="2034291at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="60" mass="6980" checksum="7106935C5340DC7C" modified="2010-10-05" version="1">MAKKGNRVQVILECTEHKESGLPGMSRYITTKNKKNTTERLELKKFNPVLRKVTVHKEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIV2</accession>
    <name>D7VIV2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SNARE-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10921</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998478.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10921"/>
    <dbReference type="EnsemblBacteria" id="EFK60004">
        <property type="protein sequence ID" value="EFK60004"/>
        <property type="gene ID" value="HMPREF0766_10921"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044208_6_1_10"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK60004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="216" mass="24705" checksum="BC6FF20B8F986286" modified="2010-10-05" version="1">MEVISSLIDFILHIDKHLVEIVNDYQTWTYLILFIIIFAETGFVVTPFLPGDSLLFATGAIIAKPETDLNIWLMWVLLMVAGILGDMVNYHIGKYIGPKAFSGKYRFLKKDYLDKTEKFYEKYGGKTIIYARFVPIVRTFAPFVAGVGSMSYRKFASYNVIGAIVWVSSFLFLGFKFGELEFVKKNFTYVILGIIVFSILPPVVEVIKEKFKKKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ32</accession>
    <name>D7VJ32_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">OmpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HMPREF0766_11001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002138.1">
        <property type="nucleotide sequence ID" value="NZ_GL379779.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11001"/>
    <dbReference type="EnsemblBacteria" id="EFK59167">
        <property type="protein sequence ID" value="EFK59167"/>
        <property type="gene ID" value="HMPREF0766_11001"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047401_0_0_10"/>
    <dbReference type="OrthoDB" id="583204at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103647">
        <property type="entry name" value="SSF103647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0626">Porin</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107010" evidence="11">
        <location>
            <begin position="24"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="12">
        <location>
            <begin position="325"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="242"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFK59167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="438" mass="47260" checksum="879F81919E48EAEC" modified="2010-10-05" version="1">MKLNLKSAAVFTIAGLLTSTSFAQSTATVEGTTPFGSSSEYRTWSFGVNAGVLNLSNVFGVNRRGYNSLENNIGYSAYIKKQISPSFGLKAQYLGGKVAGKTEDGSRSYETKTPWSAALSGEFTLANTNFRFFNSIIKPYFAIGLGALNFEPTTKAGNTETTHDSKTKLFVPADFGFKFAISKGVNLDLGYQLNWANQDFDGARVGTIKHDLFSYAHAGVEFALGNSSKPALSNSNPVATLVNDYTAKYDQLKAEREALVAANNALKSQVDQLNADLKDDDGDGVANKYDKCPNTPSGTKVDGAGCPLPVAETKVVEKIVVTEEDRKVVDEAIKNLEFDLGKSTIRSTSYPSLDRVASLLIEKNFSLKLAGHTDNTGSMKTNLRLSKERAEAVKAYLSGKGANPSRIEATGYGPNQPIASNATAEGRQQNRRVEFTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJB1</accession>
    <name>D7VJB1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000526.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11080"/>
    <dbReference type="EnsemblBacteria" id="EFK58964">
        <property type="protein sequence ID" value="EFK58964"/>
        <property type="gene ID" value="HMPREF0766_11080"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097532_0_0_10"/>
    <dbReference type="OrthoDB" id="1519412at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025350">
        <property type="entry name" value="DUF4254"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14063">
        <property type="entry name" value="DUF4254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="201" mass="23677" checksum="7F5DBD98A1E96EAB" modified="2010-10-05" version="1">MISAIANPIFQRAIEDYHVNDAIDHPIENPYDKTSLEHLLYLKCWIDTVQWHMEDVVRNPEIDPKDALYWKRRIDESNQYRTDTVEYIDSYYLQKYADIQPLDDAKVNTESPAWAIDRLSILALKIYHMEQETLRSDAAAEHIEACQQKLNILLEQRKDLSVSIDELLNDIEQGHKYMKVYKQMKMYNDPALNPVLYTAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJR2</accession>
    <name>D7VJR2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">proA</name>
        <name evidence="9" type="ORF">HMPREF0766_11231</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000844.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11231"/>
    <dbReference type="EnsemblBacteria" id="EFK59115">
        <property type="protein sequence ID" value="EFK59115"/>
        <property type="gene ID" value="HMPREF0766_11231"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030231_0_0_10"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="7"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="422" mass="46391" checksum="87EC14FC608126D3" modified="2010-10-05" version="1">MILYSYNVENITSQLLAARAATQAIQHIPAEKRAQVLIQLADVLEQHVPEILDANQTDLDAMDKEDPKYDRLLLTAERIDGLCSSLREIAILEDPTGKLLSSKRLENGLLVEKKTVALGVVAVIYESRPNVSIDVAALCIRSGNVCLLRGGSDAWHTNTVLVKLIRKVLADMSVDPAVVQLLPTARKFVTELLEATKYVDIIIPRGSQSLIDFVRNHAKVPVIETGAGVCHTYVESTADLDKAAAIVANAKISRPSVCNALDTVLVDREIANTFLPKLVDAFSKAEVEVFADNTAYEVLKNERYPFLKHAEESDFGREFLDLKCSIKVLDNTEEALDHIALYSSRHSECIISNDAEKIERFMNSVDAAAVYANASTRFTDGGEFGLGAEIGISTQKLHARGPFALEKLVTEKWFVTGDGQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJY6</accession>
    <name>D7VJY6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Preprotein translocase, YajC subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yajC</name>
        <name evidence="9" type="ORF">HMPREF0766_11305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998750.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11305"/>
    <dbReference type="EnsemblBacteria" id="EFK58588">
        <property type="protein sequence ID" value="EFK58588"/>
        <property type="gene ID" value="HMPREF0766_11305"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1862">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116157_5_2_10"/>
    <dbReference type="OrthoDB" id="2082059at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01853">
        <property type="entry name" value="YAJCTRNLCASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK58588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="107" mass="11771" checksum="C1DF4EC0E744EC71" modified="2010-10-05" version="1">MISTIFLQAGGSGGGFMTFLPMILIIVVFYFFMIRPQMKKQKDHKKYIEELGVNTKIVTTAGIHGRIVEVSETTFLVDVGSGVKIRFDKSAIALDASKAANDANKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK17</accession>
    <name>D7VK17_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xanthine phosphoribosyltransferase</fullName>
            <shortName evidence="1">XPRTase</shortName>
            <ecNumber evidence="1">2.4.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">xpt</name>
        <name evidence="2" type="ORF">HMPREF0766_11336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine</text>
            <dbReference type="Rhea" id="RHEA:10800"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.22" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998839.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11336"/>
    <dbReference type="EnsemblBacteria" id="EFK58619">
        <property type="protein sequence ID" value="EFK58619"/>
        <property type="gene ID" value="HMPREF0766_11336"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099015_0_0_10"/>
    <dbReference type="OrthoDB" id="1532478at2"/>
    <dbReference type="UniPathway" id="UPA00602">
        <property type="reaction ID" value="UER00658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000310">
        <property type="term" value="F:xanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046110">
        <property type="term" value="P:xanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01184">
        <property type="entry name" value="XPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010079">
        <property type="entry name" value="Xanthine_PRibTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01744">
        <property type="entry name" value="XPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-phospho-alpha-D-ribose 1-diphosphate binding" evidence="1">
        <location>
            <begin position="127"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="189" mass="20711" checksum="A1168581D0DA4110" modified="2010-10-05" version="1">MDILKDRILKDGQSFAGGILKVDSFINHQMDPVLMKSIAVEFVRRFGHLPVNKIITIEASGIAPAIMLGYLLELPVVFVKKAMPKTMQNMLVSSVYSFTKDKTYDICVSRDFLGPADRVVFIDDFLANGNAALGICDLVKEAGATLLGMGFIIEKSFQMGGELLRAMPDIQVESLAKIKKLGDGHIIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK33</accession>
    <name>D7VK33_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glutathione synthetase, ATP-binding domain protein</fullName>
            <ecNumber evidence="12">6.3.2.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HMPREF0766_11352</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="12"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998883.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11352"/>
    <dbReference type="EnsemblBacteria" id="EFK58635">
        <property type="protein sequence ID" value="EFK58635"/>
        <property type="gene ID" value="HMPREF0766_11352"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068239_0_0_10"/>
    <dbReference type="OrthoDB" id="878336at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006284">
        <property type="entry name" value="Glut_synth_pro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004218">
        <property type="entry name" value="GSHS_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004215">
        <property type="entry name" value="GSHS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21621:SF4">
        <property type="entry name" value="PTHR21621:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02955">
        <property type="entry name" value="GSH-S_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02951">
        <property type="entry name" value="GSH-S_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="135"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK58635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="335" mass="37777" checksum="E58DD8410540C339" modified="2010-10-05" version="1">MKIAFVINQTHKEEASFTTTLLALRALQRGHDICYIGLADFVYLEEERVAAHARSVAPSPDIKDTKQLLDILRSTAKLRIEMDHIDVMWLRFDPVLDMIGRPWAATMGLQFAQLAQKQNVLVINDPHALIGAENKLYLENFPEEVRPKTMVTRSYEDVLQFFEEQDQHIILKPLKGSGGKNVFMVNKNEVKNLKQIVEVICRDGYLIAQEYLPEAQKGDIRFFLLDGEPVVVNGKYASVNRVQQAGEIRSNIHQGAKAQVAHITPEILTLVGKVAEKLKHDGMYFVGLDIVGNKIMEINVFSPGALPQASALNEEDYTTVIIENLEKKVSLNKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK39</accession>
    <name>D7VK39_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11358"/>
    <dbReference type="EnsemblBacteria" id="EFK58641">
        <property type="protein sequence ID" value="EFK58641"/>
        <property type="gene ID" value="HMPREF0766_11358"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140339_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012861">
        <property type="entry name" value="DUF1634"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07843">
        <property type="entry name" value="DUF1634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="142" mass="15522" checksum="7D8CD264E7A9CB2E" modified="2010-10-05" version="1">MGLIINSNHMKKLFSKDYWADQDIEILVGQILRIGVISASIVVIIGGIVYLIAHGQQLVPDYQHFVGEGEVNTTISGILEGVAKFQAPQIIQFGVVILIATPILRIICSLFGFVLERDRLYIIITCIVLAIITFSILGGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKC5</accession>
    <name>D7VKC5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK58727">
        <property type="protein sequence ID" value="EFK58727"/>
        <property type="gene ID" value="HMPREF0766_11444"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3173345_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="47" mass="5289" checksum="7A6CD1B1D716B184" modified="2010-10-05" version="1">MKAIHNLERLNPEKPPVVVNIIKSKNESNSQPGYEMFSLGSGCCKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKC7</accession>
    <name>D7VKC7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK58729">
        <property type="protein sequence ID" value="EFK58729"/>
        <property type="gene ID" value="HMPREF0766_11446"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2958444_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="59" mass="6634" checksum="8A5F78D671EB2787" modified="2010-10-05" version="1">MKAIHNLRKMKQLNTLVVVNIIKSKNESNSQLTVVLVSPKCVVVNIIKSKNESNSQLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKE5</accession>
    <name>D7VKE5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5017 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999186.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11464"/>
    <dbReference type="EnsemblBacteria" id="EFK58747">
        <property type="protein sequence ID" value="EFK58747"/>
        <property type="gene ID" value="HMPREF0766_11464"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031WDC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066814_0_0_10"/>
    <dbReference type="OrthoDB" id="1733299at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032185">
        <property type="entry name" value="DUF5017"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16409">
        <property type="entry name" value="DUF5017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5017" evidence="1">
        <location>
            <begin position="16"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="308" mass="33759" checksum="3511CC641EEEEEC9" modified="2010-10-05" version="1">MKKIVYILSLCYILVACEKRENLPVSLSVSTEKANYKVGDTVRFTLSGNPDQLVFWSGEESHRYIYRDRTRAESEVIQLSFATNRRYGADAQQPGSLRLLATQNFNAVYDATGIKPSDWVDITSAFTLSPIQSNDATYAPSGTVNILALQQTGLTVDVQKPIYFAFKYTGVTGSTQPRWWINAFNINTITSDGQVLAVSGIKEAGWKFVKVLPSSQVTWIFGTDNILKYAGGAAAVGSNQVWAVTAGLNLTSVSPDTGVPLKNMATRMDTYSHVYTKPGKYTVTFVAANANIYGQDQVTKDVTINVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKG6</accession>
    <name>D7VKG6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_11485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999242.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11485"/>
    <dbReference type="EnsemblBacteria" id="EFK58768">
        <property type="protein sequence ID" value="EFK58768"/>
        <property type="gene ID" value="HMPREF0766_11485"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_71_10"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="265"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="339"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="416"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="379"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="635" mass="73644" checksum="CA4DD64E0A15D475" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKS8</accession>
    <name>D7VKS8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HPt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999480.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11597"/>
    <dbReference type="EnsemblBacteria" id="EFK58880">
        <property type="protein sequence ID" value="EFK58880"/>
        <property type="gene ID" value="HMPREF0766_11597"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157042_0_0_10"/>
    <dbReference type="OrthoDB" id="1808456at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="3">
        <location>
            <begin position="4"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="103" mass="11975" checksum="0FD284B395C58353" modified="2010-10-05" version="1">MMDNSDIIREFITLYVAQTPVDEEALRTAIRNNNLNEIASKAHHIKPTMEYIGAFALKDRIITIESLAKEQADINLIKDEFAILEKQLQDLYQELQHYLNSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKZ3</accession>
    <name>D7VKZ3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999653.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11662"/>
    <dbReference type="EnsemblBacteria" id="EFK58266">
        <property type="protein sequence ID" value="EFK58266"/>
        <property type="gene ID" value="HMPREF0766_11662"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045521_0_0_10"/>
    <dbReference type="OrthoDB" id="786563at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107060" evidence="1">
        <location>
            <begin position="21"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="438" mass="46600" checksum="588760E2E9CC3D4A" modified="2010-10-05" version="1">MKRNKLYVGLALLVLGVASCKPEIKDFTPAAGGTANFSKYIAVGNSLTSGFADGGLYREGQQVAFTNLMAQQFKQVGGGEFTTPLFSEAQANGSGYIQLESLVNGQPVMKQITENLAYRSASPKLLTKYTDPIQNLGVPGMRLDLAFVPQFSSLNMYFERLLPDDQVGKKTYFTYATEHDHTFFSFWLGNNDALGYATNGAVYNPLDPTTKLTDLATFTGAYQNFINGLTAKGSQGVVATIPDVTAVPFFTTVTRAALLAAANAAAKAANPNAPEIKDIYIATKTTPRAATDKDYFVLPFSSAGLLGKPNGANIPYGLHPANPVADNFVLDEAEAAQVVTRINEFNAAIKSIATAKGLAVADVNAFLTSVKNGIRINGLAVSNKFITGNAFSLDGIHLTPIGNAIVANVFIDAINSKYGSSVSKVDVSQFRGVKLPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL82</accession>
    <name>D7VL82_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11751</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999862.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11751"/>
    <dbReference type="EnsemblBacteria" id="EFK58355">
        <property type="protein sequence ID" value="EFK58355"/>
        <property type="gene ID" value="HMPREF0766_11751"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_3_2_10"/>
    <dbReference type="OrthoDB" id="144124at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="23"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="383"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="509" mass="57211" checksum="B8A2F9A662609E73" modified="2010-10-05" version="1">MKNTGFIKILALGALFLASCNKDYLDTVPTEKIGTPTVFETTANVKLAVNGLAKMMTSQYLESQGFNGEGTIKMYYGNYPGNHFFVNLGGWAAIINAGYNENVTSIYLYYPWYYYYKIIGNANIIIHSVDAATGPESEKQFLKAQALTYRAYSFMMLAQIYGYRWSDSNNGSTSGLILRTDMSTGDKALSTLGESYAQIYDDLNTALALYEQSGLKRTKNFEVNKDVAYAIYARAALNRQDYINAEKYAKLAVQDYPLMSVNDYKAGFSTPNAEWIWSSYGALDENLHFYSFFSYIGYNSSAGAVRNTPKCISRELFNKIPATDIRKGLFLDPKTDAYTTSTGVAGAALKARAFQLFPALQSNATTYAYMQFKLKATDMPGVGNLNHFRSSEMYLIEAEAKYFQNKPASEVQTVLNNLTAKSGRDAQYNATATGEDLLKEIKKYRAIELWGEGFDWFDMKRWGDSIDRKIYANGGNFITDLAKVITPEKNNKWTWRIPLRESDYNGALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLE4</accession>
    <name>D7VLE4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_11814</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11814"/>
    <dbReference type="EnsemblBacteria" id="EFK58417">
        <property type="protein sequence ID" value="EFK58417"/>
        <property type="gene ID" value="HMPREF0766_11814"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_1_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107076" evidence="5">
        <location>
            <begin position="23"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="137"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="463"/>
            <end position="1121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1173" mass="129810" checksum="08C11449B01D41D1" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLI1</accession>
    <name>D7VLI1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000148.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11851"/>
    <dbReference type="EnsemblBacteria" id="EFK58454">
        <property type="protein sequence ID" value="EFK58454"/>
        <property type="gene ID" value="HMPREF0766_11851"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054483_0_0_10"/>
    <dbReference type="OrthoDB" id="1977684at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="SSF117281"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107285" evidence="1">
        <location>
            <begin position="25"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="329" mass="35853" checksum="056F4FC21744BEE0" modified="2010-10-05" version="1">MNKKNWLILFLACTIALTSFNSCKKSDDTDSNTDTGPAEWFKTSAFDGDPRSAAAYFSIGDNGFITTGILRTNERVKDTWLFDSKKGSWSKKADFIGDARNAAVGFAINGVGFVGTGYNGTDALNDFYKYDSATDKWTAIAPLPGEARYGAVAFSLGGFGYVGLGSTKAEKTLKDFYKYDPATNTWTSVGTIFANKRVNAFSFVIGNTAYVGGGFDNNSFPEDFYKFDGTTWTRLKDIKTDDIDVTRQSASAFTVGQTAFVVGGKKSSILNSTWRYNPSSDSWESKHQAFQGSAREGAAAFSVNGKGYITTGANGTFKFDDTWEFIPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLR2</accession>
    <name>D7VLR2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_11932</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000319.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11932"/>
    <dbReference type="EnsemblBacteria" id="EFK58535">
        <property type="protein sequence ID" value="EFK58535"/>
        <property type="gene ID" value="HMPREF0766_11932"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032SSJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140821_0_0_10"/>
    <dbReference type="OrthoDB" id="2012249at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="109" mass="12658" checksum="786B518AD1C1B6A2" modified="2010-10-05" version="1">MSQTNNNSLPNSTVTRDLRQLDKGTDNLYESIVVISKRANQVAVDMKEELNGKLAEFASNNDNLEEVFENREQIEISKHYERMPKPTLVAIDEFLHDKVYFRNPSKEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLV7</accession>
    <name>D7VLV7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage Tail Collar Domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK57962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001024.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11954"/>
    <dbReference type="EnsemblBacteria" id="EFK57962">
        <property type="protein sequence ID" value="EFK57962"/>
        <property type="gene ID" value="HMPREF0766_11954"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087872_1_1_10"/>
    <dbReference type="OrthoDB" id="1837650at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011083">
        <property type="entry name" value="Phage_tail_collar_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037053">
        <property type="entry name" value="Phage_tail_collar_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07484">
        <property type="entry name" value="Collar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Collar" evidence="1">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="199" mass="20580" checksum="3C60FF0ED8BD5B26" modified="2010-10-05" version="1">MEGTMAEIRLFAGNFAPKTWALCYGQTLAISTNQALFSLLGTTYGGNGVTTFQLPDFRGRIPVGTGSGQTVGMGTITSGQKAGIENVTLFENNLPAHVHQVSISGTLPLTVSKSVADKSTVIDGLSLAAPARSAGRAKTPTLGYNSQTGSISLNPASIDLSGMTLALAPVGNTIAHNNLQPALGLNYIICLQGIYPSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM44</accession>
    <name>D7VM44_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class II glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">purF2</name>
        <name evidence="2" type="ORF">HMPREF0766_12041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001279.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12041"/>
    <dbReference type="EnsemblBacteria" id="EFK58049">
        <property type="protein sequence ID" value="EFK58049"/>
        <property type="gene ID" value="HMPREF0766_12041"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0034">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_431919_0_0_10"/>
    <dbReference type="OrthoDB" id="267682at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="9"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="636" mass="72333" checksum="B32BB47DCB664740" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM52</accession>
    <name>D7VM52_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycoamylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001308.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12049"/>
    <dbReference type="EnsemblBacteria" id="EFK58057">
        <property type="protein sequence ID" value="EFK58057"/>
        <property type="gene ID" value="HMPREF0766_12049"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023287_1_0_10"/>
    <dbReference type="OrthoDB" id="1384939at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019282">
        <property type="entry name" value="Glycoamylase-like_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10091">
        <property type="entry name" value="Glycoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoamylase-like" evidence="1">
        <location>
            <begin position="621"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="716" mass="82234" checksum="2C3EE5F8D4F4B701" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM62</accession>
    <name>D7VM62_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sel1 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001335.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12059"/>
    <dbReference type="EnsemblBacteria" id="EFK58067">
        <property type="protein sequence ID" value="EFK58067"/>
        <property type="gene ID" value="HMPREF0766_12059"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0790">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017853_0_0_10"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="828" mass="95713" checksum="D8DFDD2D5E8C4221" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM94</accession>
    <name>D7VM94_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12091"/>
    <dbReference type="EnsemblBacteria" id="EFK58099">
        <property type="protein sequence ID" value="EFK58099"/>
        <property type="gene ID" value="HMPREF0766_12091"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_9_2_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="48"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="209" mass="25429" checksum="62EBBFE6D418C3ED" modified="2010-10-05" version="1">MAIFDDAACLLCTLNRIYMSELFKQHLQKFIVIDEEKFNDVLSFFELKTVKKKENVLVEGQVCKFNYFVLNGCMRMFFINEKGVEHTTQFAIENWWITDNMAYEHQLQTEFYIQAVEDTRLLTLHAESQEKLLSRYPEMERYFRYIYQRAYAAAQRRIKYIYDFSREELYNHFQLVNPQFVQRIPQYLIASYLGFTPEYLSEIRRKKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMG9</accession>
    <name>D7VMG9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001527.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK58174">
        <property type="protein sequence ID" value="EFK58174"/>
        <property type="gene ID" value="HMPREF0766_12166"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122293_0_0_10"/>
    <dbReference type="OrthoDB" id="1948290at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="192" mass="21684" checksum="7D80F56C9432C823" modified="2010-10-05" version="1">MLNSDTYSYPDKFTDILLKTRNSGFNMASDIHTGSLLKTLSASKPNARFLELGTGTGLSTSWLLSGMDESSTLLSVDHDPAFLTIAQEYLSSDPRLTLVQQDAGEWLLENKELKFDFIFADTWHGKFLELSTCLDMLDRGGIYFIDDLLPQPNWPEGHDQKVRNLIRDLDIRADLCLTRLHWSTGVIVAVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMH7</accession>
    <name>D7VMH7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12174"/>
    <dbReference type="EnsemblBacteria" id="EFK58182">
        <property type="protein sequence ID" value="EFK58182"/>
        <property type="gene ID" value="HMPREF0766_12174"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50348XY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152539_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="143" mass="16546" checksum="C946656BB2FBFB7C" modified="2010-10-05" version="1">MANHFVIFLYKGDKTMINNEDNNKQGKTDEEKDNLADNLSYNTEKDSYELDVDDDDPDYDHPADYDTLAEGAEDDDSTYDDSNPFVGDEYADEDDLEADDWEKEGMHETDAEHLRVSRKDQELSRTAEDLRDDLDEEGYPKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMK1</accession>
    <name>D7VMK1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992634.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12221"/>
    <dbReference type="EnsemblBacteria" id="EFK57148">
        <property type="protein sequence ID" value="EFK57148"/>
        <property type="gene ID" value="HMPREF0766_12221"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031JTV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_821125_0_0_10"/>
    <dbReference type="OrthoDB" id="1358817at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107437" evidence="1">
        <location>
            <begin position="22"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="338" mass="39192" checksum="9C8E75250504A635" modified="2010-10-05" version="1">MKSINYAFLLLLSLSGSVVSAQSKEELKKKYENSDLHKETEKKMRNTHNYPDSVILPPLHFTNSFVQLDSTITDFQSFSIDVDILNDIPDEYAFYISPFNIQLNGMPVYGGIQTHSDGYSVKDNVYQQIGRGGIFSRWYERSKEATNSAGYYNSSDGEGDFISVRNKLNWNKGKYRLKLTKTKYEKGKSIAPDFIPKDLYFSWGDVEHSWVTYTVENLQTHRTDTIGSLAFPGKKIRMDKTIVYFTEQYHKYFDFGTPDRHLGDNFIYYKDIPVIDMTLSNLTINGKVFIPKEIKTYHNRTHHPDQDQIKMPMPVLSRDKYDPATGVLTYRIGELVHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMN4</accession>
    <name>D7VMN4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">pyrH</name>
        <name evidence="8" type="ORF">HMPREF0766_12254</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12254"/>
    <dbReference type="EnsemblBacteria" id="EFK57181">
        <property type="protein sequence ID" value="EFK57181"/>
        <property type="gene ID" value="HMPREF0766_12254"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0528">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033861_0_0_10"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="31"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="36"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="159"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK57181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="261" mass="29401" checksum="FF96814B158E7610" modified="2010-10-05" version="1">MIFFKQAIKGLKKLSYLWLLENFQKKIMKYKRILLKLSGEALMGEQNYGIDIHRVRQYANDIKEIHSLGMEIAIVIGGGNIYRGLSAEKSGMDRVQADYMGMLATVINSMALQDALEKVELKTRLLTAIKMEQICEPFIRRRAVRHLEKGRIVIFGAGTGNPYFTTDTAASLRAIEINADAVLKGTRVDGIYTADPEKDPSATRFDEISFTEVYERGLNVMDMTAFTLCQENNLPIIVFDMNKEGNLKKLANGEHVGTVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN72</accession>
    <name>D7VN72_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12442"/>
    <dbReference type="EnsemblBacteria" id="EFK57369">
        <property type="protein sequence ID" value="EFK57369"/>
        <property type="gene ID" value="HMPREF0766_12442"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3030112_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107457" evidence="1">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="55" mass="6092" checksum="E95C1A3E2EFE7A4A" modified="2010-10-05" version="1">MKRIALFIIVMAATTVMISSGTAGELERSPNVEMIKSMNELKNSVDSLTRILNHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN89</accession>
    <name>D7VN89_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993004.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12459"/>
    <dbReference type="EnsemblBacteria" id="EFK57386">
        <property type="protein sequence ID" value="EFK57386"/>
        <property type="gene ID" value="HMPREF0766_12459"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2195257_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="108" mass="12262" checksum="C8B1E715E8ABC86B" modified="2010-10-05" version="1">MDLNMKYSVPFPVDLLKSIGFEDGGNCWGDGCENYRTIWLGNGITIDVVSMRKVFLQCDNSYKELPEVNDISKLIIILKLLGSKSPIDFEVLQIYPGIYDIAPEREEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN92</accession>
    <name>D7VN92_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase family protein</fullName>
            <ecNumber evidence="1">5.4.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.-" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993009.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12462"/>
    <dbReference type="EnsemblBacteria" id="EFK57389">
        <property type="protein sequence ID" value="EFK57389"/>
        <property type="gene ID" value="HMPREF0766_12462"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_9_5_10"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="208" mass="23401" checksum="0C1BD8660EBA528A" modified="2010-10-05" version="1">MGKVKNIITIQHPESVHHINGMIGSWTDWPLTESGREQASNIAFNLGKEVEGKSYLLYSSPLLRTKETAEIIGATLLITPQFSDALKERSLGKAVGQSVAWLKENIEREELTVFDRCFDDAESRSDVWERLYPFYDDVLSDAAENIILISHGDTLSIFNVMWLGLELEALNAIELYGVSGSISFLQQNIEGKRIIRKLGDTSYMKIMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN94</accession>
    <name>D7VN94_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57391">
        <property type="protein sequence ID" value="EFK57391"/>
        <property type="gene ID" value="HMPREF0766_12464"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2773801_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="69" mass="8020" checksum="F6067DA16DF2E15A" modified="2010-10-05" version="1">MLADEADGHIGMVFKIRTGRPLNGVVKKNNTKPIHKVRLIFSQVIFSYVDVKTFITFGRYPNVYFVIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNB4</accession>
    <name>D7VNB4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12484"/>
    <dbReference type="EnsemblBacteria" id="EFK57411">
        <property type="protein sequence ID" value="EFK57411"/>
        <property type="gene ID" value="HMPREF0766_12484"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072993_4_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="57" mass="6293" checksum="BDAABDBEC9112034" modified="2010-10-05" version="1">MVIRKGKVVKCPVDVPHWHGASADTAFVQVVITGREKGETVWLKPVTDAEYHSGPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VND7</accession>
    <name>D7VND7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative chlorophyll synthesis pathway protein BchC</fullName>
            <ecNumber evidence="3">1.1.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gutB</name>
        <name evidence="3" type="ORF">HMPREF0766_12507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.14" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993074.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12507"/>
    <dbReference type="EnsemblBacteria" id="EFK57434">
        <property type="protein sequence ID" value="EFK57434"/>
        <property type="gene ID" value="HMPREF0766_12507"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_10"/>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="27"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="169"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="338" mass="37023" checksum="E1054CE94E905DAE" modified="2010-10-05" version="1">MKKLVCLTPGEFVYTEESVAALPADYTLLRMKRLGICGTDYHAFEGTQPFFSYPRILGHEIAAEVIDTQENKDLKTGDLVTISPYFYCGKCIACRRGKTNCCVNIKVFGVHIDGAMQEYIAVPTSSVLKGRGLTADELATVEPLAIGAHGVRMAQIEPGDNVLILGAGPIGLGTIAFAKIAGGNVMVLDVNDNRLNFCREKLDVEHTINPLKMDASEQIKTITNGDMATVIIDCTGNLNAINNGFQHLAHGGKFIMIGLQKGTIEVVHPEFHKREAVLMSSRNALPLDFDFVISCIRNGQIKPMDFITHRLTFDEVKDKFSTLSDKDADVIKALIVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNG3</accession>
    <name>D7VNG3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_12533</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993105.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12533"/>
    <dbReference type="EnsemblBacteria" id="EFK57460">
        <property type="protein sequence ID" value="EFK57460"/>
        <property type="gene ID" value="HMPREF0766_12533"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014042_0_0_10"/>
    <dbReference type="OrthoDB" id="468283at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041532">
        <property type="entry name" value="RlmI_PUA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17785">
        <property type="entry name" value="PUA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="394" mass="44290" checksum="3FCC51EC398251C5" modified="2010-10-05" version="1">MKSVILNKGKDKAAWQLHPWVFSGAVNNVSGNVENGEVVSVFNSDREFIAYGIYHNQSRVAVRLLEWHPDTTIDENWWRNRIRKAVEARQHLLTAETNTVRLIFAEADFIPGLIADKYADYISIQVHAAGTENVKAVIIDELTRLLQPKGIYERSDLKSREHEGLPNTNGLLSGELPPEFVDVVENGIRYKVNIIDGQKSGFYCDQRENRFLTAQYVKDKKVLDCFCYSGGFTLNSIQQGAAAVTAVDSSALAIETLERNMVVNGFDTSGHQFILSDVNKQLRTFIEEEARFDVVILDPPKYAPSRSSLEKASRAYKDLNRRGMMLLESGGLLATFSCSGAMDISTFKQVIAWAALDAGKEIQFIRQFHQPEDHPVRASFPEGEYLKGLLVRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNH9</accession>
    <name>D7VNH9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase, C-terminal domain protein</fullName>
            <ecNumber evidence="9">1.3.8.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gcdH</name>
        <name evidence="9" type="ORF">HMPREF0766_12549</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.6" evidence="9"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993127.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12549"/>
    <dbReference type="EnsemblBacteria" id="EFK57476">
        <property type="protein sequence ID" value="EFK57476"/>
        <property type="gene ID" value="HMPREF0766_12549"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_8_2_10"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045008">
        <property type="entry name" value="ACX4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43188">
        <property type="entry name" value="PTHR43188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="76"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="191"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="301"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK57476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="450" mass="49731" checksum="2C551CE0EA6A42A8" modified="2010-10-05" version="1">MFDKIKNMMGLMKSVDLEQIEKISKKIDLKQVMEAISKMDDKQLQAVTKMLTGGGNKKKELPPINGDFYDIDAKLSPEDRALQLKVRSFMETEIKPIVNNYWLRDEFPFEIIPKFAALNIAGYTYEGYGCAGGTSLMEGVVAAEIARVDASIATFFGVQSGLAMGSIYICGSDEQKQEWLPKMQKMEVIGAFGLTEPEVGSGAAGGLTTTCQKTEQGWVLNGQKKWIGNSTFSDITIVWARDLDDGEVKGFIVRKETPGFEVEKIKGKMALRIVQNGLITMTNCVVAESDRLQNANSFKDTAKVLQMTRAGVAWMAVGCARGAYENALDYTRQRKQFGKPIAAFQLIQNHLVEMLSNLTAMQTLVFRLSELQDAGQLKDEHASLAKVFCSLRTRDIVSKAREVMGGNGILLEYNVARFLADAEAIYSYEGTKEINSLIVGRSITGFSAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNI5</accession>
    <name>D7VNI5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Voltage-dependent potassium channel beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993134.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12555"/>
    <dbReference type="EnsemblBacteria" id="EFK57482">
        <property type="protein sequence ID" value="EFK57482"/>
        <property type="gene ID" value="HMPREF0766_12555"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_10"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="16"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="329" mass="37073" checksum="049A15A5A2E03888" modified="2010-10-05" version="1">MEYRRMGKTGLQLSVLSFGSWVTFARQTDDQQNDRLMSLAYDAGINFFDNAEVYSNGLSEEMMGRILKQKDWDRSSYVVSSKAFFGWKGADKKPNQHGLSRKHLTEACHEALTRLQVEYLDLYYCHRPDKNVPVEEVVRTMNTLIQQGKILYWGTSEWSAAEIVEAHAAAGRLGLEAPAVEQPEYNLFNRQKMEADYLTIFKNLGMGTTIWSPLASGLLTGKYNNGIPEDSRLALEGYGWLKDRALAQDKLNRVEELGKLAVQLGVSLPTLAIAWCVRNPNVTTAILGATKESQLLENLKALEVLPLLTPEVLTQINDIMQTKPFVSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNL3</accession>
    <name>D7VNL3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993168.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12583"/>
    <dbReference type="EnsemblBacteria" id="EFK57510">
        <property type="protein sequence ID" value="EFK57510"/>
        <property type="gene ID" value="HMPREF0766_12583"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9MM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119992_0_0_10"/>
    <dbReference type="OrthoDB" id="1415295at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018899">
        <property type="entry name" value="Conjug_transposon_Tra0"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10626">
        <property type="entry name" value="TraO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107079" evidence="1">
        <location>
            <begin position="21"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="186" mass="21110" checksum="3F1142170F85F69C" modified="2010-10-05" version="1">MKKYIYTVMLVLMGITMAQAQRMLPKQKGLEISTGVLSNDKIGNDYYISVAMTVNGKNGNYQLWALEYTHQYHDYKDLRIPQESYSAEGGYSFYLLGDARKNITLNLGITGVVGYESINRGEAMLYDGSKILSEDNFIYGAGGRLTFETYLSDRFVLVLQGRTKVLWGKDLEQFRPSVGMGLRFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNN0</accession>
    <name>D7VNN0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12600"/>
    <dbReference type="EnsemblBacteria" id="EFK57527">
        <property type="protein sequence ID" value="EFK57527"/>
        <property type="gene ID" value="HMPREF0766_12600"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2994411_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="57" mass="7008" checksum="10752853BCDA86BB" modified="2010-10-05" version="1">MQRHLEELDKSRTASSRLSLLHLIRPEGRIFVFTRTRQDTIMKSKLFRDFFENKIQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNR6</accession>
    <name>D7VNR6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12636</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993247.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12636"/>
    <dbReference type="EnsemblBacteria" id="EFK57563">
        <property type="protein sequence ID" value="EFK57563"/>
        <property type="gene ID" value="HMPREF0766_12636"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121830_0_0_10"/>
    <dbReference type="OrthoDB" id="1031920at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="72"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="187" mass="21525" checksum="F1368B8448ED4B53" modified="2010-10-05" version="1">MNTLFIKNMVCDRCIMVVQNELDKLGLDAKNVKLGEVTLTKEITPTEKEALVKTLEPLGFEVIDDKKGRIIEKIKNIIIDLVHHQDSDVKTNLSDVLSDKLHHDYNYLSNLFSEVEGTTIEKYFIAQKVEKVKELLVYDELSLSEIAMRLNYSSVAYLSNQFKKVTGLTPSYFKQVREDKRKPLDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNU3</accession>
    <name>D7VNU3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Omega-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Relaxing enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Swivelase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Untwisting enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">topB</name>
        <name evidence="12" type="ORF">HMPREF0766_12663</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993293.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12663"/>
    <dbReference type="EnsemblBacteria" id="EFK57590">
        <property type="protein sequence ID" value="EFK57590"/>
        <property type="gene ID" value="HMPREF0766_12663"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_5_2_10"/>
    <dbReference type="OrthoDB" id="100725at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005738">
        <property type="entry name" value="TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025589">
        <property type="entry name" value="Toprim_C_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13342">
        <property type="entry name" value="Toprim_Crpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01056">
        <property type="entry name" value="topB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK57590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="694" mass="78373" checksum="574B7D5CF90BBE06" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNU8</accession>
    <name>D7VNU8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12668"/>
    <dbReference type="EnsemblBacteria" id="EFK57595">
        <property type="protein sequence ID" value="EFK57595"/>
        <property type="gene ID" value="HMPREF0766_12668"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZVFT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_787217_0_0_10"/>
    <dbReference type="OrthoDB" id="1564787at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="348" mass="40546" checksum="0D170E4E66E5EEDF" modified="2010-10-05" version="1">MYILTEMNSIKDLIYFDYDKAKSLNSQLNDGLLSRLTKTIEEESGDNSEIGIDIKILKAKVGGNGKDKNIKTETIEIYHELLNQIETSLFKKGILTDINDKFENDGKSFNDFLQEVPSFKYIKATGWSTFEDFERFKRIMSNFNEIQRLIYGSAIKNNPEIKKQKEQINELKRDLKKNPNSQKELIRLIAIEKNFDKQLESQVNANFLDETFIEGVQIFLDTFSAHRLNFRLAPFDIFNDFQILANLKNEYLVNGSFDDIIYTYGSRPNIKLSVFGIITSCPQKKDNRKDLNDEYLGYDDSELEDSELFIKAFRNVFSSFQGFEKFFFVPSYPKISISPIAIYQEIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNZ5</accession>
    <name>D7VNZ5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heavy metal efflux pump, CzcA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cusA</name>
        <name evidence="2" type="ORF">HMPREF0766_12715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993378.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12715"/>
    <dbReference type="EnsemblBacteria" id="EFK57642">
        <property type="protein sequence ID" value="EFK57642"/>
        <property type="gene ID" value="HMPREF0766_12715"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_2_3_10"/>
    <dbReference type="OrthoDB" id="91817at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="435" mass="48157" checksum="065809DB58586B1C" modified="2010-10-05" version="1">MVHQIIEWSMRNRFIVLVLAIGIFVWGIFAVKKNPIDAIPDLSENQVIVFTEWMGRSPQLIEDQVTYPLVTNLQGIPKIKYVRGSSMFGMSFIYVIFEDDVDVYWARERVMERISTISSTLPQGATPQLGPDGTGVGHVLWYTLDAPDTDLGEQRAIQDWYVKFALQNVPGVSEIASFGGFQKQYQIAIDPNKLLYYKLTVPQVIAAVRSNNNEAGGRKFEMSDIGYIIKTSGYLKSIDEIANIQLKSQNGTPIRMSDIAVVQMTGETRLGIFDQDGAGERVGGIVVMRYGENAAEVIDNVKAKMTEVARGLPKGMKFDIVYDRGELIKESVDSITHTLIEEMIVVSLIVIIFLFHWRSAVSIVLQIPITIAASFILLNAFDISSNIMSLTGIALAIGVIVDNGIIMSENAYKHLAERYAEVIGANGSKANSSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP08</accession>
    <name>D7VP08_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993407.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12728"/>
    <dbReference type="EnsemblBacteria" id="EFK57655">
        <property type="protein sequence ID" value="EFK57655"/>
        <property type="gene ID" value="HMPREF0766_12728"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0644">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029779_0_0_10"/>
    <dbReference type="OrthoDB" id="1513550at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107180" evidence="2">
        <location>
            <begin position="19"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="609" mass="67597" checksum="7F70D9E98A1560A0" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP87</accession>
    <name>D7VP87_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor G</fullName>
            <shortName evidence="6">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">fusA</name>
        <name evidence="8" type="ORF">HMPREF0766_12807</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993542.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12807"/>
    <dbReference type="EnsemblBacteria" id="EFK57734">
        <property type="protein sequence ID" value="EFK57734"/>
        <property type="gene ID" value="HMPREF0766_12807"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_10"/>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="6"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="83"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="137"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK57734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="707" mass="77948" checksum="81A179088DDE06D2" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPK6</accession>
    <name>D7VPK6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_12926</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993780.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12926"/>
    <dbReference type="EnsemblBacteria" id="EFK57853">
        <property type="protein sequence ID" value="EFK57853"/>
        <property type="gene ID" value="HMPREF0766_12926"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015525_0_0_10"/>
    <dbReference type="OrthoDB" id="979208at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Elp3" evidence="6">
        <location>
            <begin position="73"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="363" mass="41132" checksum="13A77EF4931C835B" modified="2010-10-05" version="1">MLIFLVFLGMEESNYFKGRGAQVNPNNKFFVSQYVQEHIEGLDEPFLEHVPTQLIPTHPKKIISVSDSPDLHFTQSINPYQGCEHGCIYCYARNAHEYWGFSAGLDFERKILVKYDAARLLEKQFNNVNYQPSAIMLSGNTDCYQPIERKLKITRSILEVMLKYRHPVSIISKNTLMLRDLDIIEELAKLQLISVAVTINSLSEDVRQKMEPRTVTASARLKLIEKLTGKGVPVMLMVAPIVPGINSDEMPLLIKSAAAAGARSASYTIVRLNGAIADIFKDWLYKNYPDRADKVLHGIADCHNGKLNDSEFGRRIRGEGNLAESIRDLFRLSVKQHMGKNDHPTIRTDLFQVPNRGRQLGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPK8</accession>
    <name>D7VPK8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993782.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12928"/>
    <dbReference type="EnsemblBacteria" id="EFK57855">
        <property type="protein sequence ID" value="EFK57855"/>
        <property type="gene ID" value="HMPREF0766_12928"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50311XN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1694412_0_0_10"/>
    <dbReference type="OrthoDB" id="1806345at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="180" mass="21065" checksum="D7742B18DFEDABBB" modified="2010-10-05" version="1">METKNLNTTIAEPVRKQMRIEFFGQVTGLVALLFVPYYFNFNQAMTSVYIVFYALTLSFSGYYLYKFYSFYKSALTIDLENAKDLTWFYHELKLNVNIYTNFNFIMIITALAYGITCLYITNFNFDPIAHKIESLIPGTTAYIALTISTLVFLFTIAEYSAKSTYQKYEDRMKDILNQFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPQ7</accession>
    <name>D7VPQ7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993855.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57904">
        <property type="protein sequence ID" value="EFK57904"/>
        <property type="gene ID" value="HMPREF0766_12977"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50346W4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1440527_0_0_10"/>
    <dbReference type="OrthoDB" id="196910at68336"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="199" mass="23090" checksum="F85E55F3285263D1" modified="2010-10-05" version="1">MDTYNQHSTLKQYFNSVVSLDQPVHWHEYYRISKLVANMLLEKLRMDNYDSGIHMDINNTAFVKTSINAYYHLGIALEIGLNGMIGNSHDTISYPKSQRMNGVSLKQKTQNLLQLADEIGLFNKNRMDFKSFTDYENLKQVLVHLSDIIKWNERYPHAESSTTISKLSNKIPFLIFNGSHITQMVQPLFDLLESEIEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPQ9</accession>
    <name>D7VPQ9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma factor regulatory protein, FecR/PupR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12979</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993859.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12979"/>
    <dbReference type="EnsemblBacteria" id="EFK57906">
        <property type="protein sequence ID" value="EFK57906"/>
        <property type="gene ID" value="HMPREF0766_12979"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050192_2_3_10"/>
    <dbReference type="OrthoDB" id="1381035at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032508">
        <property type="entry name" value="FecR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16344">
        <property type="entry name" value="DUF4974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="113"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4974" evidence="3">
        <location>
            <begin position="254"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="322" mass="37057" checksum="6B69CB3F84BF8147" modified="2010-10-05" version="1">MKTRIFNLLIQRYRDGSATADERQLVDRWYEQLDREQLPEKSISENLQHRIYGEICSHIDGATVRQVGSMISWKFVVSIAASLFICLGVMWWMTAQDQIPLQHMVADPEIRVFETIAGERKQVILPDSSVITLNSMTRLKLDVASFNKTNRQLELSYGEAFFDVRRDTLRPFIVTSGALQTQVLGTSFTIRSYTDLPEQTVAVFSGRVQVKRNDQMLGILIKGQQIRYDKSNENSTTESFDLENRNAWIIGKTYLNKASFEELALTIRNNYGVTLQTTNTRIADQQYTLSIQKQISLDDLLQVITTVHHNKFRKEGDVVMIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPR1</accession>
    <name>D7VPR1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993861.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12981"/>
    <dbReference type="EnsemblBacteria" id="EFK57908">
        <property type="protein sequence ID" value="EFK57908"/>
        <property type="gene ID" value="HMPREF0766_12981"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034925_1_1_10"/>
    <dbReference type="OrthoDB" id="468923at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107212" evidence="2">
        <location>
            <begin position="17"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="454" mass="47146" checksum="B4C2EC378718A14B" modified="2010-10-05" version="1">MKKFLFAASVCAIALASCNKDNLAPQADFKAGLPAKPQAHVPVDVNGLITKSFLSKDTVWLIDGVSFVAPGQTLTIEAGTFLTSGNVKSYNDEVYGAQNIRGVLVVPKTAKLNAIGTAAAPIVFTSPNASGSRNPGDFGGVIMLGNATTNQPATTRIEGVPAPIGVDVTYGGSNPADNSGTLKYVRIEFAGYNLTENNEINGLTLGGVGNGTTLENIQVSWGKDDGFEFFGGTVNAKYLVASSNDDDDFDFDFGYTGTIQYALSLKDPNATNSVSGGNSDSNGLESDNNGAGDASRLPLTNPKLRNFTFLGIKDAAVAATKLKYGNRWRRASSLDIESSIIAGYATGASFESISGGNFSNNVVHGYAAAFNGSAPGSGNSTTVSSDATSYLALAGGTNIFYPVSGGFNPFVLRPTATSPAYGTGTSYKGAIDPAVTNPSQVWTFGWTQFSPKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPR7</accession>
    <name>D7VPR7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993867.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12987"/>
    <dbReference type="EnsemblBacteria" id="EFK57914">
        <property type="protein sequence ID" value="EFK57914"/>
        <property type="gene ID" value="HMPREF0766_12987"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170099_0_0_10"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="127" mass="14265" checksum="036B3605A9827D56" modified="2010-10-05" version="1">MAIHTNQSTVYHKAIRSIYEHLQYGAEKPDIKVILETSATKEIRICMKNNQLMKTHKSPFPIVIHIVQGAIRLGIATEIYDMKSGDIIGLESNIPHDLTATEDTIIRLSISHSDTAKRVQEVVNTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPS0</accession>
    <name>D7VPS0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12990"/>
    <dbReference type="EnsemblBacteria" id="EFK57917">
        <property type="protein sequence ID" value="EFK57917"/>
        <property type="gene ID" value="HMPREF0766_12990"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_386798_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044023">
        <property type="entry name" value="Ig_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19081">
        <property type="entry name" value="Ig_7"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013265939" evidence="1">
        <location>
            <begin position="16"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Ig_7" evidence="2">
        <location>
            <begin position="183"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Ig_7" evidence="2">
        <location>
            <begin position="269"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Ig_7" evidence="2">
        <location>
            <begin position="354"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Ig_7" evidence="2">
        <location>
            <begin position="437"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Ig_7" evidence="2">
        <location>
            <begin position="520"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="714" mass="73439" checksum="227DAE837960B9F6" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ40</accession>
    <name>D7VQ40_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994029.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13094"/>
    <dbReference type="EnsemblBacteria" id="EFK55891">
        <property type="protein sequence ID" value="EFK55891"/>
        <property type="gene ID" value="HMPREF0766_13094"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_9_2_10"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="15"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="189" mass="22369" checksum="A769F2622E563B3B" modified="2010-10-05" version="1">MREQLSRYIQNTITVNTDELQTILSYFKPLKPKRNELLLLQGETSQRTFFVGKGCLRIFFINEDGQESTRYFAFEDQFATALTSFITGDPSDEFIQAIEHTELLYINHNDFYHLLDIIPQWEKFYRKYLEFGYVNNTRRLQSFISMDALDRYRNLLIQSPVIVRRLPNKIVASYLGISQETLSRLKSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ44</accession>
    <name>D7VQ44_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">dnaJ</name>
        <name evidence="10" type="ORF">HMPREF0766_13098</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994036.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13098"/>
    <dbReference type="EnsemblBacteria" id="EFK55895">
        <property type="protein sequence ID" value="EFK55895"/>
        <property type="gene ID" value="HMPREF0766_13098"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_7_10"/>
    <dbReference type="OrthoDB" id="1738789at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="139"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="152"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="169"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="195"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="209"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="139"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK55895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="382" mass="41315" checksum="5730C9A4ACA29CE3" modified="2010-10-05" version="1">MSKRDYYDVLGVARGADASEIKSAYRKLAIKYHPDKNPDNKEAEEKFKEAAEAYEILSNPEKRQRYDQFGHAGNSASGFGGGGMNMDDIFSQFGDIFGGGNPFESFFGGGSRGGGGRRVQKGTNLRIKVKLTLDEIAKGVEKKVKVNKQVSCTTCNGTGAKDKSSYHTCNTCGGSGSVRRVTNTILGQMQTTSTCPTCNGEGVEITAKCTTCKGEGLTRGEETISINIPAGVSEGMQLSMSGKGNAAPRGGIPGDLIILVEEVPHEQLKRDGINVIYDLYINFADAALGTSVEIPTIDGKAKIKIDPGTQGGKILRLKGKGIPEVNSYHKGDQLIYVNVWTPKAVSSEEKALLEKLRESPNFKPQPGRSEKSFFERIKEYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQD9</accession>
    <name>D7VQD9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylglyoxal synthase</fullName>
            <shortName evidence="1">MGS</shortName>
            <ecNumber evidence="1">4.2.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">mgsA</name>
        <name evidence="4" type="ORF">HMPREF0766_13193</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dihydroxyacetone phosphate = methylglyoxal + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17937"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="EC" id="4.2.3.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylglyoxal synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.3" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994224.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13193"/>
    <dbReference type="EnsemblBacteria" id="EFK55990">
        <property type="protein sequence ID" value="EFK55990"/>
        <property type="gene ID" value="HMPREF0766_13193"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120420_1_0_10"/>
    <dbReference type="OrthoDB" id="1726279at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008929">
        <property type="term" value="F:methylglyoxal synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019242">
        <property type="term" value="P:methylglyoxal biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01422">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00549">
        <property type="entry name" value="Methylglyoxal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004363">
        <property type="entry name" value="Methylgl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30492">
        <property type="entry name" value="PTHR30492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006614">
        <property type="entry name" value="Methylglyox_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00160">
        <property type="entry name" value="MGSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MGS-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="36"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="55"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1 2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006614-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK55990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="125" mass="13408" checksum="37E2D900FF428A19" modified="2010-10-05" version="1">MKKTIALIAHDGKKAEMVAFVKDHIESLRHAHLVATGTTGSYVQQTGLPVELKLSGPKGGDAQIAAMAAEGLVNGIIFFRDPLGKHPHEPDIQMLMRICDLYNVPLATNPATGALIIEGLLEDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQL7</accession>
    <name>D7VQL7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mandelate racemase/muconate lactonizing enzyme, N-terminal domain protein</fullName>
            <ecNumber evidence="2">4.2.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dgoD</name>
        <name evidence="2" type="ORF">HMPREF0766_13271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.6" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994381.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13271"/>
    <dbReference type="EnsemblBacteria" id="EFK56068">
        <property type="protein sequence ID" value="EFK56068"/>
        <property type="gene ID" value="HMPREF0766_13271"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4948">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_3_2_10"/>
    <dbReference type="OrthoDB" id="1825548at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008869">
        <property type="term" value="F:galactonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="141"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="392" mass="44073" checksum="2FADAFFE15F7A839" modified="2010-10-05" version="1">MKITAIETYVCHARMRNWIFVKVVTDQPGLWGWGEATLEWHTKSVVGAIEDISQLLIGEDPRRIEHLWQMMYRQHFWHGNGIVRGTAISGIDIALWDILGKIHNVPCHELWGGRVRDHVRLYCHLGGGKMEDFYETAPGDAKRFGELALQAVEEGFTAFKSMAVPETMSLEGLQPIKYAEACVRAMREAVGDQIDIMVDCHARPSPRMGMMFAKALEPYGLYFFEEPCWPETMEDIALIQRAVTTPIASGERLVGVHAFRELLEKRAVSVIQPDITHCGGLTEARRIGALAEAYRVSMAPHNPQGPVSTAASLELGFSSPSYIICESVHSDVEWRSDVVSEGFTVQKQGRIVLPNQKPGLGIEINEEEVKKHPFQQEILQRTFYKDGSVGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQU7</accession>
    <name>D7VQU7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sodA</name>
        <name evidence="9" type="ORF">HMPREF0766_13351</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994481.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13351"/>
    <dbReference type="EnsemblBacteria" id="EFK56148">
        <property type="protein sequence ID" value="EFK56148"/>
        <property type="gene ID" value="HMPREF0766_13351"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031625_0_1_10"/>
    <dbReference type="OrthoDB" id="1440645at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="7">
        <location>
            <begin position="46"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="8">
        <location>
            <begin position="133"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK56148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="244" mass="27464" checksum="C81403BC0835382D" modified="2010-10-05" version="1">MENKNRRTFIKNSLGLTTGLLMTQVLTGSAVPSILGGADKFRFAKAALPYGYADLEPAIDAQTMQIHYERHYNNYVVAANEAIEAEKVDVKQAQDLLRNISKYSGKLRNNAGGAYNHELFWSVLRPVRTDNKPGGSLAKAIDTAFGSFDKFKEEFTKTALSQFGAGWAWLVADQGKLKIGGTPNQDNPLMDISAFKGVPLLGLDVWEHAYYLHYQNKRVEYVNSWWSLVNWDRVQQYFDKSDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR59</accession>
    <name>D7VR59_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13463"/>
    <dbReference type="EnsemblBacteria" id="EFK56260">
        <property type="protein sequence ID" value="EFK56260"/>
        <property type="gene ID" value="HMPREF0766_13463"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072573_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="57"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="239" mass="26997" checksum="7BAA107D3F9D7083" modified="2010-10-05" version="1">MSVAKYIAIQKNSFFLINSKLSQFPAIEYNLTQFGDALIFLSFLTVFVVLAPKLWEALIVTSLISCLYSGILKKIFAVPRPAAVFDVTSFVIIGKTLTGHNSLPSGHSVTVFSTLTVLLFAFIPQKFWHKILWIFSIVTVGLVLIFTRVGVGAHYPIDVIVGGIIGYIAGLTGIFITRKYKVCNWINCKKYYPVFIILFIACCISIFNKIIHENLIIFYFAFFSLVFSLYKTVRIYVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR60</accession>
    <name>D7VR60_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arylsulfatase</fullName>
            <ecNumber evidence="10">3.1.6.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0766_13464</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.-" evidence="10"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994630.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13464"/>
    <dbReference type="EnsemblBacteria" id="EFK56261">
        <property type="protein sequence ID" value="EFK56261"/>
        <property type="gene ID" value="HMPREF0766_13464"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018534_1_1_10"/>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012549">
        <property type="entry name" value="EptA-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040423">
        <property type="entry name" value="PEA_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30443">
        <property type="entry name" value="PTHR30443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08019">
        <property type="entry name" value="EptA_B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="EptA_B_N" evidence="9">
        <location>
            <begin position="58"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="8">
        <location>
            <begin position="314"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK56261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="505" mass="57836" checksum="FF62F2A00938A4A5" modified="2010-10-05" version="1">MFKNDIKLTHFVLLISLLNFLFFHYPFFTFVFNNVDYTSFSSILMIVSLVILMLVANAFVFYLFCFLSHIFGKLLLVITFLINAVAVYFINTYNVIMDESMVGNILNTNYSESSSFFSFKLVLYILLLGVLPSIYIIKAKIVKETLKRFSITVLAALSFILVVIFLNASNWLWIDKNSKTLGGLAMPWSYSVNISLFYIHKSQKNKKEIRLPDATIKDNVKSVVILVIGESARSANFSLYGYKKDTNPLLSKIPDVMHFNANSSATYTTAGVKSILEYKDVGDLYEILPNYLDRNNVEVIWRTTNWGEPPVHIKNYQDGNFLAKTCKGEGCNYDEILITDLKEQILASKKNKNLIILHTSTSHGPSYSKKYPVQFEVFKPVCNSVELGKCSQTELINAYDNTIVYTDYILSKIIEDLKQLKEYKSAMIFVSDHGESLGEKNLYMHGLPMSMAPKEQYEIPFIVWTDGSRQLKPNNMLTQHHVFHSVLSFLNIQSPVFDEKMNIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR93</accession>
    <name>D7VR93_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994675.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13497"/>
    <dbReference type="EnsemblBacteria" id="EFK56294">
        <property type="protein sequence ID" value="EFK56294"/>
        <property type="gene ID" value="HMPREF0766_13497"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058234_0_1_10"/>
    <dbReference type="OrthoDB" id="1688876at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107828" evidence="1">
        <location>
            <begin position="21"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="297" mass="34074" checksum="25DC0DEB7DCEA77B" modified="2010-10-05" version="1">MRIRYLILILIILKCCVIEAQQSTVPVSRSSLGKLTDPRMQEASGLVASSVNKQHFWTHNDSGDEGRIFLIDNKARLRAIYTLEGVDAVDCEDIAWLEIDGEPYLLLADIGDNLAHRSFVSLYLFKEPMADTSRLVHRIPKEQIRHIPLRYPDKARDAEAIIVLPENNQIMIFSKRDFRTGIYVSDVLGDSLKNDEQLKKVGELPFNFITAADISRDGRQLIMKNLTNVYYWKLDPPTGILENLKKPFVKLPYSPEPQGEAIAFDLDGTCFYTLSEQPFGLSSYLYQYKFYNYDQNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR96</accession>
    <name>D7VR96_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994680.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13500"/>
    <dbReference type="EnsemblBacteria" id="EFK56297">
        <property type="protein sequence ID" value="EFK56297"/>
        <property type="gene ID" value="HMPREF0766_13500"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016599_0_0_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041700">
        <property type="entry name" value="OMP_b-brl_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14905">
        <property type="entry name" value="OMP_b-brl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plug" evidence="1">
        <location>
            <begin position="142"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl_3" evidence="2">
        <location>
            <begin position="334"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="774" mass="88196" checksum="95AA0CE8668CA4D6" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRA0</accession>
    <name>D7VRA0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_13504</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994686.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13504"/>
    <dbReference type="EnsemblBacteria" id="EFK56301">
        <property type="protein sequence ID" value="EFK56301"/>
        <property type="gene ID" value="HMPREF0766_13504"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_14_1_10"/>
    <dbReference type="OrthoDB" id="1532186at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="4">
        <location>
            <begin position="66"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="5">
        <location>
            <begin position="136"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="112"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK56301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="455" mass="49534" checksum="3370E77530E37ABF" modified="2010-10-05" version="1">MAKKKNRLPLILVIAAVVILVVFVAGNKLGWFGDGNVIKVAVDKVQERTVHELVSASGKIQPEFEVKLSSEVSGEIIELNIKEGDVVRKGQVLCRVKPDILQSGFDQAVASLNIQRATLASSQQQLKQQEANFVNTEATFKRNQELFKKRVISAAEMDKAEADYRSALASIEAQRQSVRATRYGIDQSQASVKQAGDNLARTTIYAPSDGVISLLSVELGERVVGTAQMAGTEIMRIANMSSMEVNVDVNENDINRVKLGDQADIEVDAFQGRKFVGVVTEIASSSKSAATTTAASTAEQVTNFNVKVRISPESYADILNNNLKNPSPFRPGLSATVQIRTKTSSGLVVPIQSVTIRTDEIKSDESKGDDEANKENKAKKAATTENAGAKEYVFVVNGKEVDMVEVKTGIQDDNYIIILSGLKKDQEVVSRPFNAISKTLKDKSKVEKVDKDKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRJ3</accession>
    <name>D7VRJ3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endonuclease MutS2</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mutS</name>
        <name evidence="7" type="synonym">mutS2</name>
        <name evidence="11" type="ORF">HMPREF0766_13597</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994795.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13597"/>
    <dbReference type="EnsemblBacteria" id="EFK56394">
        <property type="protein sequence ID" value="EFK56394"/>
        <property type="gene ID" value="HMPREF0766_13597"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011252_2_1_10"/>
    <dbReference type="OrthoDB" id="256392at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00092">
        <property type="entry name" value="MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005747">
        <property type="entry name" value="MutS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF14">
        <property type="entry name" value="PTHR11361:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005814">
        <property type="entry name" value="MutS_YshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01069">
        <property type="entry name" value="mutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="10">
        <location>
            <begin position="716"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="553"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="341"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK56394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="791" mass="89517" checksum="B91CA4EF4CA14C49" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRM7</accession>
    <name>D7VRM7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994873.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13631"/>
    <dbReference type="EnsemblBacteria" id="EFK56428">
        <property type="protein sequence ID" value="EFK56428"/>
        <property type="gene ID" value="HMPREF0766_13631"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50335TP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159948_1_0_10"/>
    <dbReference type="OrthoDB" id="2079242at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="109" mass="12434" checksum="46094418B5914A27" modified="2010-10-05" version="1">MFSTSFLLVFIGFFLWYNTSKKAGWKNKPAYLAKLGSRPQFSKFLCAALFIIATGLFVYYLGWMSGIFIAIVSIMTAGSLLVAIFPFRYLNYKSILALYAVCLLFEFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRN2</accession>
    <name>D7VRN2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13636"/>
    <dbReference type="EnsemblBacteria" id="EFK56433">
        <property type="protein sequence ID" value="EFK56433"/>
        <property type="gene ID" value="HMPREF0766_13636"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141496_0_0_10"/>
    <dbReference type="OrthoDB" id="1804290at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="153" mass="16968" checksum="8D6505ABB5F66C2A" modified="2010-10-05" version="1">MEIFVLICVGIFGSLLSFYTHVHLKQGPIRSSALLTMLVAGFLYFFPELLSPYLTKNIPYVFIGSSFIGMVSSGQLSSYLGLGLAGLIFTFIFLNTSRFFDGFGGALGTSACVSLLAVMSIPYLKTNRKVTIGFLQLRRLVLKNKKRHIRKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS10</accession>
    <name>D7VS10_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13764"/>
    <dbReference type="EnsemblBacteria" id="EFK56561">
        <property type="protein sequence ID" value="EFK56561"/>
        <property type="gene ID" value="HMPREF0766_13764"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1874121_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107608" evidence="1">
        <location>
            <begin position="21"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="136" mass="15051" checksum="E84DADCFF22906A9" modified="2010-10-05" version="1">MKRPLISTILTLLTLSTVSAQNTDLILTSYSGQSQIKAQGSVTLKPGFHIPSGSTVRIYTSSSLQTHPVLQTQPSGNQNYILTRTFRKAGVTLANLSQSRTVEEENQSIQYFDGLGRPCKVYRSWLPLPTKTLYSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSA3</accession>
    <name>D7VSA3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arginase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rocF</name>
        <name evidence="3" type="ORF">HMPREF0766_13857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995441.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13857"/>
    <dbReference type="EnsemblBacteria" id="EFK56654">
        <property type="protein sequence ID" value="EFK56654"/>
        <property type="gene ID" value="HMPREF0766_13857"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_6_2_10"/>
    <dbReference type="OrthoDB" id="1598732at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="PTHR43782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="319" mass="35786" checksum="41B4070E80BE6DEF" modified="2010-10-05" version="1">MRRSIELIKNRSDIGAGTRGSDLGIDAIEIAAINKGSLFFKKYPFVDVQTRNDSVYENDFNPFGKHIKQVYQQCKQVASIVEDSILKENFPLVFSGDHSSAIGTISGIKAALPDKRLGVIWIDAHADIHSPYTTPSGNLHGMPIAAVLQKDNLLSRINEVDSHTQTYWEKLKHVGTAEPKLMAEDLVYFGVRDTEEPEDMLIERLGIKNYQVGEVRTKKVEQCVKEVFDQLKNCDILYVSFDVDSMDSEKISEGTGTPVPEGFFPFEVTLLLQELIRSEKVVCMEVVEVNPLLDHHGNRMAEVTFDILEQVAPVIESTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSD1</accession>
    <name>D7VSD1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995502.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13885"/>
    <dbReference type="EnsemblBacteria" id="EFK56682">
        <property type="protein sequence ID" value="EFK56682"/>
        <property type="gene ID" value="HMPREF0766_13885"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50334V5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146677_0_0_10"/>
    <dbReference type="OrthoDB" id="1929406at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107526" evidence="1">
        <location>
            <begin position="22"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="126" mass="14635" checksum="32A85C7D51FA50F7" modified="2010-10-05" version="1">MKNSIVLLFLSAYLFSTTELAQVLKIPVLIQHYAEHKQYEDQLSIIDYLVHHYAGHEKDADWDTDMKLPFVKHINLLQFTVCLPFTPVTLPKGETVWIASETLIFYLNKEIPSYNPSAVWQPPQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VST1</accession>
    <name>D7VST1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14035"/>
    <dbReference type="EnsemblBacteria" id="EFK56832">
        <property type="protein sequence ID" value="EFK56832"/>
        <property type="gene ID" value="HMPREF0766_14035"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_16_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="412" mass="46950" checksum="9F53FB4DCFD2083D" modified="2010-10-05" version="1">MDIAIPRKNRKKQYIALSILGFLAIITAGIYLATRPSSLNIKKEEVQIKAVKYDSFEDFVVFQAQVDPLHAMLINIVEGGAVQELFVENGAMVTQGMPLARLYNPNTEFNFLSQETAIIEQMNNLNVQKLSLRNQELELSKELITIDHDYNDTKLQYDMNQKLYSNKVLAKNEWEQTQEKHRYQEERKNLIQKNISREKEVNQIQIAQINQALQAMHKSLETLRENKKNFLVLAPVSGRLSSFDAVLGQTYQAGTSIGKVDVMKGYKLMALIDEFYLEKINSGQTGNIEMKGESVPVRVSKILPEVKNGQFKIELDFTDKQPEGLQQGLSFGVKLILSGKEKKLVIPKGTFSNVSQGKWIFVVEGNKANRRSIELGRENPYYYEVISGLKEGDRIITSGYEDYKNIQLLNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSU9</accession>
    <name>D7VSU9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995824.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14053"/>
    <dbReference type="EnsemblBacteria" id="EFK56850">
        <property type="protein sequence ID" value="EFK56850"/>
        <property type="gene ID" value="HMPREF0766_14053"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050006_6_2_10"/>
    <dbReference type="OrthoDB" id="1007505at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="61"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="292" mass="32531" checksum="1D42D075DAC0E91F" modified="2010-10-05" version="1">MNSRRDFLKNLGLATAGVALAPNLDLFAAKKPWFEISLAEWSLHKTLFKGDLKNIDFPEFAVKKFGIHAVEYVNQFFKDKAKDMTYLKDLNQRAKDNGVRNVLIMIDGEGYLGDEDTAKRKEAVENHYKWVDAAAFLGCHAIRVNAAGKGTPEEVKGRVVESLSTLADYGKKSNISVIVENHGGISSHGDWLAGVLKAVGKKNCGSLPDLGNFYEYDRYQGVTDLMPYAHGVSAKSHDFDAEGNETQIDYARMMKIVKDAKFKGFVGIEYEGDKHSEIDGVLLTKKLLQKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT55</accession>
    <name>D7VT55_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TraG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_14159</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996047.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14159"/>
    <dbReference type="EnsemblBacteria" id="EFK56956">
        <property type="protein sequence ID" value="EFK56956"/>
        <property type="gene ID" value="HMPREF0766_14159"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019050_1_1_10"/>
    <dbReference type="OrthoDB" id="246216at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032689">
        <property type="entry name" value="TraG-D_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025988">
        <property type="entry name" value="YWFCY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12696">
        <property type="entry name" value="TraG-D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14293">
        <property type="entry name" value="YWFCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="YWFCY" evidence="3">
        <location>
            <begin position="5"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="TraG-D_C" evidence="2">
        <location>
            <begin position="459"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="666" mass="76166" checksum="2F2C725A90794383" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTG6</accession>
    <name>D7VTG6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996348.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14270"/>
    <dbReference type="EnsemblBacteria" id="EFK57067">
        <property type="protein sequence ID" value="EFK57067"/>
        <property type="gene ID" value="HMPREF0766_14270"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032P2E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190766_0_0_10"/>
    <dbReference type="OrthoDB" id="2227911at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="82" mass="9017" checksum="9D1374EBFD1E1ED7" modified="2010-10-05" version="1">MKTENLKEMSDEELLKKKRITSTATGVLAGMLLLLLILATYISLTKGFSALIVIPIALSPTLILNFKTVKEIKLELKSRGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTI7</accession>
    <name>D7VTI7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996390.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14291"/>
    <dbReference type="EnsemblBacteria" id="EFK57088">
        <property type="protein sequence ID" value="EFK57088"/>
        <property type="gene ID" value="HMPREF0766_14291"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052178_0_0_10"/>
    <dbReference type="OrthoDB" id="1701876at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="94"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="312" mass="35921" checksum="115D735E8A383730" modified="2010-10-05" version="1">MRLIGNVVAGMALSVLVLSTQSCGNNQSSQKTSTVEHQDSVTKKEEHNTEKKEIQTKKDTLTIDSVKKKEPVDKAKLTKAQRDSINAKLDSLPKHIYLTFDDGPLIGSSAIDSIATAKNIKINVFLIGKHANMSKRLKKDYLRYYNNPLVDCYNHSYTHANNKFSVFYSNPNHAFSDFEKNEADLALKYKITRMPGRNIWYFKDRRRIDLQSGTSTADLLYANGYEIMGWDVEWKIHGLTGKPVQSVNEIYQRMKNRLKKKDSFTANNVVLLMHDDMFQNRKGQKLLSDLIDSLKSNPNYHFEHMRDYPVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTJ3</accession>
    <name>D7VTJ3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996401.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14297"/>
    <dbReference type="EnsemblBacteria" id="EFK57094">
        <property type="protein sequence ID" value="EFK57094"/>
        <property type="gene ID" value="HMPREF0766_14297"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1585430_0_0_10"/>
    <dbReference type="OrthoDB" id="1945734at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="168" mass="18863" checksum="61F894186B2D1B5C" modified="2010-10-05" version="1">MKTTLFSAIIALLVLTSCGGKYDYGYNEKMSSLFLSCMEKVDESHEKLMNGEYNISKANNEISYDMALKNANGLIKYTNQIKTEAQELTHSEIANKFHDASIAYMTEIGDGYAPLLVKYIEEQDSVSREAIRKELILKKESVDKAADKSQEVQIEFLNKAGIKINTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTL1</accession>
    <name>D7VTL1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996422.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14315"/>
    <dbReference type="EnsemblBacteria" id="EFK57112">
        <property type="protein sequence ID" value="EFK57112"/>
        <property type="gene ID" value="HMPREF0766_14315"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_0_3_10"/>
    <dbReference type="OrthoDB" id="1617768at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="106" mass="12411" checksum="8A1CAF52406516B8" modified="2010-10-05" version="1">MNLRRDVFQAVADPTRRAILLLVATQSMTAGAIASNFDTARPTVSRHLQILTECELLTSKQNGREITYQLNPYKMKEIADFIEPFRQMWEERFNKLETIMKQYKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGK0</accession>
    <name>D7VGK0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB family domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tonB</name>
        <name evidence="3" type="ORF">HMPREF0766_10119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996624.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10119"/>
    <dbReference type="EnsemblBacteria" id="EFK59202">
        <property type="protein sequence ID" value="EFK59202"/>
        <property type="gene ID" value="HMPREF0766_10119"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_874077_0_0_10"/>
    <dbReference type="OrthoDB" id="1997695at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106880" evidence="1">
        <location>
            <begin position="19"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="2">
        <location>
            <begin position="242"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="318" mass="36813" checksum="081B6F76B9FE32A7" modified="2010-10-05" version="1">MKLLLVLFFVCCYSASNAQQNLVNYFKKDNGPAKKENAYYYRVLNIPESKLDTIFIKEFYVNGNKPKLTAKTKKIQNPTTYYGNVYRYYENGNLASKEFYSTDGIAIDSAFYYYPEGQLRDVWYYKSVYENDKTKVKDSLYIKHFDTTGKLVLKDGNGTATSYWDKDTESGEYVNHKKNGLWKGTFNDKKYRFEEQYNAGKLVKGTTYDSLNNETLYTQQEIAPEYPGGIRSLMQKVANTFKYSREMMENNINGTVIISFVVKKDGKVDNIEIEKDLGYGSGEAGVRVVENLRKWSPGIQRGIPVNVRYRLPIRLNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGM1</accession>
    <name>D7VGM1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_10140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10140"/>
    <dbReference type="EnsemblBacteria" id="EFK59223">
        <property type="protein sequence ID" value="EFK59223"/>
        <property type="gene ID" value="HMPREF0766_10140"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_1_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="151"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="451"/>
            <end position="1105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1107" mass="124510" checksum="B2E3678C6B4F4132" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGP7</accession>
    <name>D7VGP7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antioxidant, AhpC/TSA family</fullName>
            <ecNumber evidence="2">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.15" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996776.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10166"/>
    <dbReference type="EnsemblBacteria" id="EFK59249">
        <property type="protein sequence ID" value="EFK59249"/>
        <property type="gene ID" value="HMPREF0766_10166"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072057_0_0_10"/>
    <dbReference type="OrthoDB" id="1635603at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033395">
        <property type="entry name" value="DUF5106"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17127">
        <property type="entry name" value="DUF5106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="162"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="305" mass="35035" checksum="FA3F05AA8FA891AC" modified="2010-10-05" version="1">MKNLVLIASCTAFIIACQSPYRKENNVNDKNIDSLTASIHGQEHKHYLAEHYWDDMPFSDSISTAGLPAFKESLADYLLLLHTFQPSVAKETMTGFLNRKITSATLLLQMGDLLENYLYDPLSPLRNDELYATFLKYKLTFPNIEDMYLVRTRYQLNIISKNNVNQTAENFTYMTAHSKKTSLSAIKSNYTLLYFYNPDCPYCKDTTAKMKHSNVLKELKTVRQGLSILAICTEPTKNTWTDYILSLPADWINGYNDKLPTQQLYDLRALPSLYLLDENKKVICKDATFEQIETILAELQQQGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGP8</accession>
    <name>D7VGP8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10167"/>
    <dbReference type="EnsemblBacteria" id="EFK59250">
        <property type="protein sequence ID" value="EFK59250"/>
        <property type="gene ID" value="HMPREF0766_10167"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2976965_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="58" mass="6781" checksum="F5C90EB048F2CD03" modified="2010-10-05" version="1">MFGRIVHFRVYAVPLESVVIKKQNENKKPNSNLQNGIPYIEFSARYIGINMHKIVQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGU0</accession>
    <name>D7VGU0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dipeptide epimerase</fullName>
            <ecNumber evidence="5">5.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_10209</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4 5">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the mandelate racemase/muconate lactonizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996878.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10209"/>
    <dbReference type="EnsemblBacteria" id="EFK59292">
        <property type="protein sequence ID" value="EFK59292"/>
        <property type="gene ID" value="HMPREF0766_10209"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4948">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_4_0_10"/>
    <dbReference type="OrthoDB" id="951991at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016855">
        <property type="term" value="F:racemase and epimerase activity, acting on amino acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03319">
        <property type="entry name" value="L-Ala-DL-Glu_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034603">
        <property type="entry name" value="Dipeptide_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="6">
        <location>
            <begin position="139"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for (R)-substrate epimerization" evidence="3">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for (S)-substrate epimerization" evidence="3">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR634603-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR634603-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="365" mass="40578" checksum="1B7DC524D1833F42" modified="2010-10-05" version="1">MVITTIEIYRLSIPMEPFVIATGTMDYAQNTFIRVNTDEGIYGVGECSAFPMIVGETQNTCLVLARDFAKLWKGKDPLAIHERLAELDLYIAGNKTIKSAFDSALFDLASKHAGLPLYQFLKGERRDITTDITLGIASPEEMAEKAANLQREGAVILKVKLGKDPQTDINRIKAIRKAVGFDMPVRIDANQGWSYEQAVQALQGLEPFKIQYCEQPMRTWNDHLLPQLRTETIVPIMADESVYSHYDAERLCREDACDYINIKFSKSGGIAEALRIDAVAAEFGIPCMIGGMLESRLALAAKVHFAYAAKTVRFYDLDTCMVGHLEDPVIGGVQYDGYRISVSDAPGIGADIDPEYLKKCESWVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGU2</accession>
    <name>D7VGU2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridine nucleotide-disulfide oxidoreductase</fullName>
            <ecNumber evidence="7">1.4.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gltD</name>
        <name evidence="7" type="ORF">HMPREF0766_10211</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996884.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10211"/>
    <dbReference type="EnsemblBacteria" id="EFK59294">
        <property type="protein sequence ID" value="EFK59294"/>
        <property type="gene ID" value="HMPREF0766_10211"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_3_1_10"/>
    <dbReference type="OrthoDB" id="671513at2"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_20" evidence="6">
        <location>
            <begin position="24"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="145"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="488" mass="53714" checksum="8E4FEB1CFC0A7642" modified="2010-10-05" version="1">MGKPTGFLEYDRTLPKKEAVENRKQHYQEFVKSYSDTQLNEQAARCMNCGIPFCHSGCPLGNVIPEFNDAVYDGRWEDAYNILISTNNFPEFTGRICPAPCESACVLGINKPPVAIEEIEKHIIEIAFKNKFVKPNRSYLKTGKTVAVIGAGPAGLAAAAQLNKAGHDVVVYERDDKVGGLLRYGIPDFKLDKSIIDRRIEIMEQSGIVFRTNSEVGKNVPVSELAPFDAIVLTGGSTIPRNLQIPGRELKGVHYAMEFLKQQNKRVGQSPIEVEEITATGKNVLVIGGGDTGSDCVGTSNRHGAVSVTQFELMPQPPNARTNGMPWPTYPMLLKTTTSHEEGCQRHWSISTKSFVGDDNGNLKGAIVVDLEWETDTLGRPVKFTEIEGSEREIPCELVTLAMGFLHPQHEGLLQQLGVALDGRGNVQATEGEYRTSVDKVFSAGDMRRGQSLVVWAISEGRECARKVDEFLMGSSNLESKETIYNYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGV2</accession>
    <name>D7VGV2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta</fullName>
            <shortName evidence="1">ACCase subunit beta</shortName>
            <shortName evidence="1">Acetyl-CoA carboxylase carboxyltransferase subunit beta</shortName>
            <ecNumber evidence="1">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">accD</name>
        <name evidence="3" type="ORF">HMPREF0766_10221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996908.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10221"/>
    <dbReference type="EnsemblBacteria" id="EFK59304">
        <property type="protein sequence ID" value="EFK59304"/>
        <property type="gene ID" value="HMPREF0766_10221"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0777">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015486_1_0_10"/>
    <dbReference type="OrthoDB" id="504557at2"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01395">
        <property type="entry name" value="AcetylCoA_CT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00515">
        <property type="entry name" value="accD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="25"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="280" mass="31025" checksum="20A8C0D39075C9C4" modified="2010-10-05" version="1">MSWFKREKAGINTATENKKEAPDGLWNKCPSCKKPLLNIEQIENNYVCQYCGYHIRIGSAAYFSILFDDNNFTELFSDLRSGDPIHFVDTKPYAERLVEVQAKTGLKDALRSAHGKLNGQDLVVACMDFTFIGGSMGSVVGEKIARSIDYCLEHKIPFMLISKSGGARMMEAAFSLMQMAKTSAKLALLSQAKIPYICLLTDPTTGGVTASYAMLGDINIAEPGALIGFAGPRVIKETIKKDLPKGFQTSEFLLEHGFLDFIVDRRELKQKVSTFLKLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGX5</accession>
    <name>D7VGX5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="16">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="16">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 20" type="primary">metG</name>
        <name evidence="20" type="ORF">HMPREF0766_10244</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 16">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 16">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="16"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996974.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10244"/>
    <dbReference type="EnsemblBacteria" id="EFK59327">
        <property type="protein sequence ID" value="EFK59327"/>
        <property type="gene ID" value="HMPREF0766_10244"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_1_2_10"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005524">
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    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
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    </dbReference>
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    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
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    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
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    <dbReference type="CDD" id="cd02800">
        <property type="entry name" value="tRNA_bind_EcMetRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
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    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
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        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
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        <property type="entry name" value="Met-tRNA_ligase_1"/>
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        <property type="entry name" value="Met-tRNA_synth"/>
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        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
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        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="SSF57770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00399">
        <property type="entry name" value="metG_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 16 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="12 16 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 16 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 16 18" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 16 17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 16 17" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="11 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TRNA-binding" evidence="19">
        <location>
            <begin position="588"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="16">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="16">
        <location>
            <begin position="342"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EFK59327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="689" mass="78637" checksum="73287C035EDB9A65" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH28</accession>
    <name>D7VH28_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 9">Xylose isomerase</fullName>
            <ecNumber evidence="2 8 9">5.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">xylA</name>
        <name evidence="11" type="ORF">HMPREF0766_10297</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8 9">
            <text>alpha-D-xylose = alpha-D-xylulofuranose</text>
            <dbReference type="Rhea" id="RHEA:22816"/>
            <dbReference type="ChEBI" id="CHEBI:28518"/>
            <dbReference type="ChEBI" id="CHEBI:188998"/>
            <dbReference type="EC" id="5.3.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the xylose isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.5" evidence="2 8 9"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997116.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10297"/>
    <dbReference type="EnsemblBacteria" id="EFK59380">
        <property type="protein sequence ID" value="EFK59380"/>
        <property type="gene ID" value="HMPREF0766_10297"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037261_1_0_10"/>
    <dbReference type="OrthoDB" id="481478at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009045">
        <property type="term" value="F:xylose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00455">
        <property type="entry name" value="Xylose_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013452">
        <property type="entry name" value="Xylose_isom_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001998">
        <property type="entry name" value="Xylose_isomerase"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00688">
        <property type="entry name" value="XYLOSISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02630">
        <property type="entry name" value="xylose_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51415">
        <property type="entry name" value="XYLOSE_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0859">Xylose metabolism</keyword>
    <feature type="active site" evidence="8">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK59380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="442" mass="50080" checksum="C1A57CD9B00FB8B5" modified="2010-10-05" version="1">MNYIKGQKEFFAGIGQIQYEGLDSDNPFAFRWYDPNRIVRGKSMAEHLKFACAYWHSFNGNGADPFGGATHIFPWDQKADAVDRAKDKMDAAFEFMTKMQLPYYCFHDVDLVDYTNNVAENERRLQAITAYALDKQQESGIKLLWGTANLFSHERYMNGAATNPDFHVLSHGAAQVKAALDATIALGGQNYVFWGGREGYMSLLNTNMKREQEHLARFLHLAKDYARKNGFSGTFFIEPKPCEPTKHQYDYDAATVISFLRQYDLLDDFKLNLEVNHATLAGHTFQHELQVAADAGLLGSIDANRGDEQNGWDTDQFPYNINELTESMLIILEAGGFQGGGINFDAKIRRNSTDREDLFFAHIGGMDLFARALLIADKILEKSSYLQLRKERYQSFDTGKGAEFEKGNLSLEDLRDFAAANGEPEVKSGKQEFLENLINRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHT2</accession>
    <name>D7VHT2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide biosynthesis protein</fullName>
            <ecNumber evidence="4">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">capD</name>
        <name evidence="4" type="ORF">HMPREF0766_10551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997702.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10551"/>
    <dbReference type="EnsemblBacteria" id="EFK59634">
        <property type="protein sequence ID" value="EFK59634"/>
        <property type="gene ID" value="HMPREF0766_10551"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013560_5_2_10"/>
    <dbReference type="OrthoDB" id="662797at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_2" evidence="3">
        <location>
            <begin position="292"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="638" mass="72285" checksum="5C85506B749870CB" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHV4</accession>
    <name>D7VHV4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997763.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10573"/>
    <dbReference type="EnsemblBacteria" id="EFK59656">
        <property type="protein sequence ID" value="EFK59656"/>
        <property type="gene ID" value="HMPREF0766_10573"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032UYA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071048_0_0_10"/>
    <dbReference type="OrthoDB" id="1951686at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="326" mass="37912" checksum="D6A2CAC7362CA4A0" modified="2010-10-05" version="1">MIRIVIVFLLTVYSGYGYAQEIKDSVLSTANRISYLLEKVDRFNKEPLYQLEVESLFSFSILINGCPVYSNFDKISGMVRLDINPYILKSGKQLITVELYPGYDQQNMRKQFLENGSKFSLKIEKTGWGKEGYQSISEEILSYKTADETTDLTKLQTYKRDISFNASVPYRLEGWKNGKDLTQLDKKQLEEQVLHFYKQIISLFERNDYDALNSQFMKADAEWYQSMYFSEDIITRFQTTKGRKAKSVMTMLSGSQQNSRTFFPLENYVLRFYGDGRMVRLEPTEGINKGESLLGYVDDKNGMSRRTFVDMLLYIPKGETALKIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHX9</accession>
    <name>D7VHX9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">23S rRNA (Uracil-5-)-methyltransferase RumA</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rumA</name>
        <name evidence="7" type="ORF">HMPREF0766_10598</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997828.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10598"/>
    <dbReference type="EnsemblBacteria" id="EFK59681">
        <property type="protein sequence ID" value="EFK59681"/>
        <property type="gene ID" value="HMPREF0766_10598"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014689_7_2_10"/>
    <dbReference type="OrthoDB" id="1421660at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="6">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="469" mass="53263" checksum="A195DF254B187962" modified="2010-10-05" version="1">MRRRIPQEKKFISDIAVIDIAEEGKGVGKTDELVLFIDKAIPGDVVDVELIRKKKNFAEAKVAALKKASEYRIDPFCEHFGVCGGCKWQHMDYNGQLKFKQQTVDNVLARIGKVDTSIMEPILGSGETEYYRNKLEYTFSNKRWLTSVDDANEGLEMNALGFHVPGRFDKILDIDHCYLQQDPSNAIRNQIRAFAIEHQISFYDLREHAGALRNLIIRTASTGELMVIVVFAYPQEGQVELLMNYINNSFPDIDSLLYIINQKKNDTIFDQDIHIFKGRDFIYEEMEGLKYKIGPKSFYQTNSLQAYELYKITREFAGLTGDELVYDLYTGAGTIANFVAKTAREVIGVEYVPTAIEDAKINSAINQIGNTKFYAGDMKDVLTADFIAEHGKPDVVITDPPRAGMHGDVVQRLLEMEAEKIVYVSCNAATQARDLALLNEKYTVDRIKPVDMFPHTQHVENVVLLKLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI97</accession>
    <name>D7VI97_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="2">1.1.1.271</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">wcaG</name>
        <name evidence="2" type="synonym">fcl</name>
        <name evidence="4" type="ORF">HMPREF0766_10716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:18885"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.271"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998065.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10716"/>
    <dbReference type="EnsemblBacteria" id="EFK59799">
        <property type="protein sequence ID" value="EFK59799"/>
        <property type="gene ID" value="HMPREF0766_10716"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_18_0_10"/>
    <dbReference type="OrthoDB" id="1558163at2"/>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="15"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="168"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="320" mass="35766" checksum="47B378B3FF5B7F12" modified="2010-10-05" version="1">MDANPLLNSKIYIAGHRGMVGSAIERVLRARGYTNIIGKTSSELDLRDQQQVGDFFEKENPQVVIDAAARVGGILANSTYPYQFLIENLQIQNNLIDFAVKGNVEKFIFLGSSCIYPKFAAQPLTEDSLLTDTLEPTNEAYAIAKIAGVKACEAVRKQYGKDFVSLMPTNLYGVNDNFDLNSSHVLPAMIRKFHEAKISGDQPVILWGSGTPLREFLFVDDLAEATIFALENTLPEHLYNVGTGEDLSIRDLAITIQEIVGHKGEILWDTEKPDGTPRKLMDVSKMHALGWKHRVELKAGIQTTYQWFLANTDRYKEVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIE5</accession>
    <name>D7VIE5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein</fullName>
            <ecNumber evidence="3">2.7.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">uhpB2</name>
        <name evidence="3" type="ORF">HMPREF0766_10764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998157.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10764"/>
    <dbReference type="EnsemblBacteria" id="EFK59847">
        <property type="protein sequence ID" value="EFK59847"/>
        <property type="gene ID" value="HMPREF0766_10764"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_756269_0_0_10"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="51"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="278"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="366" mass="42351" checksum="C5D48ABD51A28582" modified="2010-10-05" version="1">MNKKIENGANNFNDQKNESDYIKGQYSLFEEDFDRDELCFDIFFKEGPFGIMLLDRYFQIGRLNQKLEKMLEYKPKEMLGRQVFEFLAGEDALSLKSVLQNGQALKTPLLVSLRFIKDKNKVLITDTYVRKYKTKIGDEQYCLLIFDKEFSPNGQLLELKQEIYHTIIATQEQERQNIGSLLHDSTAQLLYAIRLNLQHQTLKSGEKDWMLPMKEMLNEAIFQIRNISMDLVPSVLNDFGLKAAIGSMSERITIPDFQVIPLVQEKCEELSEEMKLAIYRIVQELLNNCMKHAVATRIRVKVTMKDDWVNVEVGDNGKGFKKEVKECMEEGSGLRNIQNRINFYNGSIKIKTQNTGTTVLVTLQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIJ3</accession>
    <name>D7VIJ3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">DNA repair protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">radA</name>
        <name evidence="8" type="ORF">HMPREF0766_10812</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998249.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10812"/>
    <dbReference type="EnsemblBacteria" id="EFK59895">
        <property type="protein sequence ID" value="EFK59895"/>
        <property type="gene ID" value="HMPREF0766_10812"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018264_0_1_10"/>
    <dbReference type="OrthoDB" id="505485at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01121">
        <property type="entry name" value="Sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01498">
        <property type="entry name" value="RadA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
        <property type="entry name" value="DNA_repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00416">
        <property type="entry name" value="sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RECA_2" evidence="7">
        <location>
            <begin position="73"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Lon-protease-like" evidence="5">
        <location>
            <begin position="357"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RadA KNRFG motif" evidence="5">
        <location>
            <begin position="258"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="102"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="461" mass="50626" checksum="ADE03874010BA01D" modified="2010-10-05" version="1">MAKSKSAYFCQNCGYESPKWLGQCPSCKQWNSFVEEVVEKGNSKVPEWRSTTTTSVSKRANKAAIIHEIIYQDESRILTPDQEFNRVLGGGIVPGSLVLIGGEPGIGKSTLMLQLALSIPQVKTLYISGEESEQQIKMRAERLSQSSKANCYILTETSTQNIFKQIEAVQPDVIVIDSIQTLHSSQIESAPGSVSQVRECTAELLRFAKETSTPVFIVGHITKDGSIAGPKVLEHMVDTVLQFEGDRHHVYRILRAVKNRFGSASELGIYEMQGSGLREVSNPSEIMISQRDAPVSGVSIAAMLEGMRPMMIEVQALVSNSAFGTAQRSSTGYDTKRLNMLLAVLEKRFGFRLSAQDVFLNIAGGLRVEDPAIDLAVIVAIISSQQDMPIKTTIAFAGEVGLSGEIRAVNRIEQRIAEAEKLGFEGIFISKFNIKGLDPKKYNIAIRPMATLEDIFRALFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIN0</accession>
    <name>D7VIN0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacterial virulence protein (VirJ)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998326.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10849"/>
    <dbReference type="ESTHER" id="9sphi-d7vin0">
        <property type="family name" value="VirJ"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK59932">
        <property type="protein sequence ID" value="EFK59932"/>
        <property type="gene ID" value="HMPREF0766_10849"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3946">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094145_0_0_10"/>
    <dbReference type="OrthoDB" id="1254521at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010333">
        <property type="entry name" value="VirJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06057">
        <property type="entry name" value="VirJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106994" evidence="1">
        <location>
            <begin position="20"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="VirJ" evidence="2">
        <location>
            <begin position="37"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="226" mass="25326" checksum="F3939BD40670A7D6" modified="2010-10-05" version="1">MKKNWGLLAALMILMVVQAQQNTVPMKEWQGNTKVPFILFFSGDGGLNTFSSNLCSTLANKGYGISAVDSKKYFWNKKSPQQLANDMAVYLHKILDKRPNTQFVIAGFSFGADAVPFLVNRLPADLKNKLYRAIMIEPSTSTDLEIHLADMVGRSRVKRSLDVIAEINKIENTQTLLLMGNDTRDFPSSQLITKHLRIQVLKGDHHFDGHEDEVANAVISELTSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIX2</accession>
    <name>D7VIX2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein ApaG</fullName>
            <ecNumber evidence="2">3.1.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">apaG</name>
        <name evidence="2" type="ORF">HMPREF0766_10941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998519.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10941"/>
    <dbReference type="EnsemblBacteria" id="EFK60024">
        <property type="protein sequence ID" value="EFK60024"/>
        <property type="gene ID" value="HMPREF0766_10941"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2967">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128074_0_0_10"/>
    <dbReference type="OrthoDB" id="1835593at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007474">
        <property type="entry name" value="ApaG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036767">
        <property type="entry name" value="ApaG_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04379">
        <property type="entry name" value="DUF525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110069">
        <property type="entry name" value="SSF110069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51087">
        <property type="entry name" value="APAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApaG" evidence="1">
        <location>
            <begin position="3"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="128" mass="14816" checksum="89C87E45BB1502E0" modified="2010-10-05" version="1">MVSLITEGVKISVESIYQPEYSNPEKEHFMFAYRISIENVGDYTVQLLRRHWQIFDAIGEHREVEGDGVVGEQPVIQPGESHQYVSGCNLKSEMGYMEGTYQMSRQLDGEIFYVEIPRFNLIANHRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIY7</accession>
    <name>D7VIY7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Futalosine hydrolase</fullName>
            <shortName evidence="1">FL hydrolase</shortName>
            <ecNumber evidence="1">3.2.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Futalosine nucleosidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Menaquinone biosynthetic enzyme MqnB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mqnB</name>
        <name evidence="3" type="ORF">HMPREF0766_10956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>futalosine + H2O = dehypoxanthine futalosine + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:25904"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:58863"/>
            <dbReference type="ChEBI" id="CHEBI:58864"/>
            <dbReference type="EC" id="3.2.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.26" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998547.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10956"/>
    <dbReference type="EnsemblBacteria" id="EFK60039">
        <property type="protein sequence ID" value="EFK60039"/>
        <property type="gene ID" value="HMPREF0766_10956"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031248_3_1_10"/>
    <dbReference type="OrthoDB" id="1860206at2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00991">
        <property type="entry name" value="MqnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019963">
        <property type="entry name" value="FL_hydrolase_MqnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03664">
        <property type="entry name" value="fut_nucase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="31"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK60039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="205" mass="22872" checksum="BDEBF2E523ABC854" modified="2010-10-05" version="1">MKTLIVAATSFEIQPFLEKKQDNPACETLITGVGMTNTAYQLGKHLANNHYNLIINAGIAGSFDKNLMIGEVLEITEDRFAELGAEDGATFLPIERLGFGQSVYFSTTPPDWKIRLDSYKKCTAITVNKVHGHEQTIEDVKRLFPSVSLESMEGAAVFMAAAEENIPVIQLRSISNYVERRNRETWNIPLAIKNLNAQLLDLLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ29</accession>
    <name>D7VJ29_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002132.1">
        <property type="nucleotide sequence ID" value="NZ_GL379779.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10998"/>
    <dbReference type="EnsemblBacteria" id="EFK59164">
        <property type="protein sequence ID" value="EFK59164"/>
        <property type="gene ID" value="HMPREF0766_10998"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_2_4_10"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="285" mass="32523" checksum="4A3432522FD42ADC" modified="2010-10-05" version="1">MKKTLLVPTDFSNNSMAAAKYASKLAIERDYSIHLIHYYTTASSSFPSEELSKEFENSAILKADLTILEFEKKLQEEFPSVYYTHRTSRGLLKENLPLEAKKEGYEAIVMGTKGLGDSKSELWGSNTSSIASKSPIPVLAIPGYYNVFKTGRIALLTNFKEDELHTLNEFIDTFGEINALDLIHVYQESEQEATVIQKIEAWKSRIFQQLSLENINYYIDKEQKDKEDLDTVPEVIHKLVEQHAPDIVLITKSRKSFFKRLFYPSVSKAVVLDINKPSYFSKVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJB5</accession>
    <name>D7VJB5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, group 2 family protein</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000539.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11084"/>
    <dbReference type="EnsemblBacteria" id="EFK58968">
        <property type="protein sequence ID" value="EFK58968"/>
        <property type="gene ID" value="HMPREF0766_11084"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_24_0_10"/>
    <dbReference type="OrthoDB" id="1445278at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="269" mass="31310" checksum="3CE62A7A5C6A59AA" modified="2010-10-05" version="1">MLASVIISTYNSPEWLKKVLIGYSIQTYKDFEVIIADDGSDNSTKVIIEEFKNIFTSLIHVWHEDNGFRKCEILNKAIVASSSPYLIFTDGDCIPRKDFVETHISNRKRKHFLSGGYFKLPLSISQDITPYDIQTQNCFDLKWLRKKKLPYSFKNQKLSTYKGFLRILNALTTTKPTWNGHNASGWKEDILAINGFDERMKYGGEDREMGERLLNNSILPIQIRYKAICIHLDHARGYVNKRDWELNNAIRRQTKKNKSIWTIHGIDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJL1</accession>
    <name>D7VJL1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fasciclin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000718.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11180"/>
    <dbReference type="EnsemblBacteria" id="EFK59064">
        <property type="protein sequence ID" value="EFK59064"/>
        <property type="gene ID" value="HMPREF0766_11180"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_487178_0_0_10"/>
    <dbReference type="OrthoDB" id="485530at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106956" evidence="1">
        <location>
            <begin position="22"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="37"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="526" mass="59593" checksum="9C5005D247B477EE" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJL3</accession>
    <name>D7VJL3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11182</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000722.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11182"/>
    <dbReference type="EnsemblBacteria" id="EFK59066">
        <property type="protein sequence ID" value="EFK59066"/>
        <property type="gene ID" value="HMPREF0766_11182"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_1_3_10"/>
    <dbReference type="OrthoDB" id="554994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="21"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="326"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="488" mass="55779" checksum="F3D9820568846520" modified="2010-10-05" version="1">MKRIIFILFAFIITFSSSCNKWLDVKPENEQISDSYWSNKEEVEAVLGAAYVKMQQSVQLMLVWGEARGNGLSLGGFINNDLQRFKSFDVIPSNSFVKWSNFYSIINYANMVIRYAPEVVAKDPSFNEATMRSYLSEAYYLRALAYFYIVRNFKDAPLILEPYMDDQTSFEIATSTSAQIFTQIISDLQQSIGSSKEFWPTVWETKGRVTKWAVYATLADVYLWTEQYDLAIEACDKVLNSGRVGLIQGKVNTKNNWFTIFSPGNSNEGIFEIQFDFTKNQTNSLVSWFGSSYNWIISPLMVARFQQNPDDIRGLGASYSGVDFKVWKYLGSEGGTTIPRQNSDQNWILYRMADIYLMKAEAYVMKGAGHYQEALDLVSAVRARAGITQPLSIASNQLEMLNIVLNEKALEFIGEGKRWYDLLRVGKRNNYEYKDYLIEQVLLGTAGGSSPIIRSKLLNNNSHYLPIHIDELKSNRLLVQNPYYDSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJP7</accession>
    <name>D7VJP7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="13">1.1.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">3-IPM-DH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Beta-IPM dehydrogenase</fullName>
            <shortName evidence="13">IMDH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">leuB</name>
        <name evidence="16" type="ORF">HMPREF0766_11216</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 13 14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="13"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000799.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11216"/>
    <dbReference type="EnsemblBacteria" id="EFK59100">
        <property type="protein sequence ID" value="EFK59100"/>
        <property type="gene ID" value="HMPREF0766_11216"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_3_10"/>
    <dbReference type="OrthoDB" id="1551125at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01033">
        <property type="entry name" value="LeuB_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="PTHR42979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 13 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13 14" id="KW-0520">NAD</keyword>
    <keyword evidence="10 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="15">
        <location>
            <begin position="4"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="13">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="13">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFK59100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="357" mass="39179" checksum="BEB6435DEC635756" modified="2010-10-05" version="1">MKKNILIIPGDGIGQEVTTWGKKALEKVATKYGHDFIFDEAIMGHTAIEATGDPLPAETLEKAKSSDAILFGAIGHAKYDNDPSAKVRPEQGLLKIRKELGLYANLRPILLFDELLDASSLKPEVLRGTDILFFRELTGDVYFGEKKRNEDNTFASDLMNYHRYEVERIARKAYEAARTRSKKLCSVDKANVLETSRLWREVVQELAKEYSDVETEHMFIDNAAMQLVKNPKKFDVVLTANLFGDILTDEASQIAGSMGMLASASVGDGTGFFEPIHGSAHDIAGQNKANPLASILSAALMLDISFGLHTEAKELTQAVADTLKAGWRTGDIANASTPAEQVLGTKEMGARVLEFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJW4</accession>
    <name>D7VJW4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11283"/>
    <dbReference type="EnsemblBacteria" id="EFK58566">
        <property type="protein sequence ID" value="EFK58566"/>
        <property type="gene ID" value="HMPREF0766_11283"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1097970_0_0_10"/>
    <dbReference type="OrthoDB" id="1851189at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107032" evidence="2">
        <location>
            <begin position="23"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="219"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="253" mass="28843" checksum="1EAB1FE11829E1C8" modified="2010-10-05" version="1">MKKMKYIIMSVCSLFLWKHIEAQTVLNSSGNYVWNANVEPKVFNKKLQLSFVSAAEGFPDYGTVLAGGGYWDDQDGAAFQLYVPYSNYYGGNAPQIRMGKYDNGGWTAWHTFYTSVNANNKDTDWKAKNLFIEEKIGIGTSSPDYRLDVVGAVRAHELRVETTKTADYVFEEGYKLPDLKTTQRFIKEHGHLPGIPSAVEMRRDGINVGDLQIDLLKKIEELTLHLIEKEQQLQTQQEELNALKVQFKTFLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJW5</accession>
    <name>D7VJW5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11284"/>
    <dbReference type="EnsemblBacteria" id="EFK58567">
        <property type="protein sequence ID" value="EFK58567"/>
        <property type="gene ID" value="HMPREF0766_11284"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_914994_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="304" mass="34317" checksum="D38DECD89FD15631" modified="2010-10-05" version="1">MKRLAILIMVMSLFPVIVWSQIRNDAGLRGDAGATSGFFEAYEPVNFPTGATNWWHLLDVRHSRPDNNHAMQFSGSFFDQYLYFRKTNNNPATPWSRVLLETNGKVGVGTLNPSTELEVNGTAIIYNKNGNNFNENLRLPSSQYGSASIALGAIPGTSGTGYGQWTLLKFSEEQASKFSIRHFHTGHLTILTNGNVGIGTEDPTERLSVNGNIRAKEIKVETNNWPDYIFEEEYKLKSLSEVETFIKTNKHLPDVPSAREIEEEGLSLGEMNKLMMKKIEELTLYLIEKDKEIQRLNKLLIKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJW8</accession>
    <name>D7VJW8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11287"/>
    <dbReference type="EnsemblBacteria" id="EFK58570">
        <property type="protein sequence ID" value="EFK58570"/>
        <property type="gene ID" value="HMPREF0766_11287"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_828687_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106967" evidence="1">
        <location>
            <begin position="26"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="320" mass="36544" checksum="5652FC47F6D2019B" modified="2010-10-05" version="1">MKNTKTAFCILLMICLAGTKLTIQAQVYRNLVEYSYNGVPTHGVKIKTNIPFMHQVDMPTVKIQGYNYGNGEVMDLTLVFYIFNNDANLPKVWASSVSTAGSYTPRIFLAQENGKVVIFIDDKNYFLRFFVDAFTHGFNNAPAYYKSWATADEALSSNEIVQLEYRNSFNGNVRFPENGVWNTNGNVGIGTTTPTERLSVNGNIRAREIKVETNNWPDYVFEEDYKLTPLAEVETFIKANKHLPEVPSAREIEEDGLSLGEMNKLMMKKIEELTLHLIEKDRQLQQQNTSQQTLLQDVNMLKERVSQQANEISQLKTKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK91</accession>
    <name>D7VK91_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase</fullName>
            <ecNumber evidence="5">2.5.1.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">metY</name>
        <name evidence="5" type="ORF">HMPREF0766_11410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.49" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999039.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11410"/>
    <dbReference type="EnsemblBacteria" id="EFK58693">
        <property type="protein sequence ID" value="EFK58693"/>
        <property type="gene ID" value="HMPREF0766_11410"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2873">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_4_0_10"/>
    <dbReference type="OrthoDB" id="637281at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="435" mass="47297" checksum="D7A0F710022F9B2D" modified="2010-10-05" version="1">MSENTNLKFETLQVHAGQVADPTTGSRAVPIYQTTSYVFENAEHGANLFALKQFGNIYTRIMNPTTDVFEKRIAALEGGVAAVAVASGQAAQFIALNNILESGENFVAGSNLYGGTYNQFKVAFKRLGIDVRFAQDSEAEHIESLIDDKTKAIYIETIGNPSFNIPDFEKIAAVAKKYDIPLIVDNTFGAGGYLFKPLEHGAHVVVESATKWIGGHGTSIGGVIVDGGNYNWGNGKFKQFSEPSEGYHGLVFADVFGPDGPFGNIQFAIRARVEGLRDFGPALSPFNSFLLLQGLETLSLRVQRHVDNALEVAQWLEAHPQVEKVSYPGLKSSPYHNNAQKYLRNGFGSVLSFAIKGDPQKANEFIDSLQLISHLANVGDTKSLIIHPAATTHQQLSEEAQIGAGVYPGLLRISVGIEHIDDIKADLQQAFEKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKK8</accession>
    <name>D7VKK8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lycopene cyclase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999353.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11527"/>
    <dbReference type="EnsemblBacteria" id="EFK58810">
        <property type="protein sequence ID" value="EFK58810"/>
        <property type="gene ID" value="HMPREF0766_11527"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042644_0_0_10"/>
    <dbReference type="OrthoDB" id="1597893at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="393" mass="46178" checksum="549FBC6F4051487B" modified="2010-10-05" version="1">MMKETEAHKNSFDYIVIGAGLSGLSLVTALKDYLISTGKKLLLIDRSFEDYANRTWSFWEEHHGNFDFLCNTRWQKLRLYVDEKQIISPTNPFTYKSVSSEDFRSYCFNIIQSHPQITMHTDDVTDIMQSKAEELIVITKSGRFMTNYVFDSRFDPDMLKQSNVNTLWQQFQGYFVKTDFAAFDEEVADIMDFRGEQKNHVAFFYTLPSATNNALIEYTLFTPILQPPEYFERNLRQYLDQHIGRNHYEITKTEEGKIPMTSYRFPKRKGNIIYLGTAAGCSKASTGYTFYFIQKQIGQILKHLKNETLDQYALSSTFDRFHFYDCILLRILKDQPEKGHRILFSMFQRNDAARVFRFLNNDTSFLEELKLFVKLPIFLFSLYALKELFGVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKL6</accession>
    <name>D7VKL6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999369.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11535"/>
    <dbReference type="EnsemblBacteria" id="EFK58818">
        <property type="protein sequence ID" value="EFK58818"/>
        <property type="gene ID" value="HMPREF0766_11535"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z88H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043652_0_0_10"/>
    <dbReference type="OrthoDB" id="384212at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011486">
        <property type="entry name" value="BBP2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07642">
        <property type="entry name" value="BBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106988" evidence="1">
        <location>
            <begin position="26"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="366" mass="41149" checksum="0195B76AA6B1C0C1" modified="2010-10-05" version="1">MNTTLKLIVMLTGICLSGISEMVFAQTNAQTNPLRFGGYAEVYYTQDFNKPGNHIRPGFLYSHNRSDEINLNLAYVKASYSADRVRSNLALAAGTYMSANYAAENDVMKNVYEANVGVRLSAKHDLWIDAGIMPSHLGFESAVGKDNWALTRSLFAENSPYFETGAKITYTTADGRWMMSALILNGWQRIRRVDGNNTLSFGHQLTFKPMERLTLNSGSFVGNDQADSIRQMRYFHNLYAIYQVSERFGLTAGFDIGAQQQKKGSKDYDVWYTPVLLARYAASDKVSLTARGEYYQDKKTVIIASDSPNGFQTFGYSANIDYHILSDVIWRTELRNLNSKDAVFTDRNQRMTDNSFTATTALAISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKT7</accession>
    <name>D7VKT7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 10">Thymidine kinase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">tdk</name>
        <name evidence="12" type="ORF">HMPREF0766_11606</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>ATP + thymidine = ADP + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 11">Belongs to the thymidine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="2 8 10"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999496.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11606"/>
    <dbReference type="EnsemblBacteria" id="EFK58889">
        <property type="protein sequence ID" value="EFK58889"/>
        <property type="gene ID" value="HMPREF0766_11606"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1435">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064400_3_0_10"/>
    <dbReference type="OrthoDB" id="1279539at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00124">
        <property type="entry name" value="Thymidine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020633">
        <property type="entry name" value="Thymidine_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="PTHR11441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035805">
        <property type="entry name" value="TK_cell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00603">
        <property type="entry name" value="TK_CELLULAR_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="95"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR035805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK58889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="192" mass="21411" checksum="FCA21DA2C7443637" modified="2010-10-05" version="1">MLFSEHNFGARRATYGSIEVICGSMFSGKTEELIRRLKRAQFAKLNVEIFKPSVDIRYDEQRVVSHDQNSISSTPVSNSSAILLLSADTRVVGIDEAQFFDDELPNVCVQLANKGLRVIVAGLDMDFKGKPFGPIPAIMAVAEHVTKVHAVCVRCGAPANYSYRLTNNDKQVLLGEKESYEPRCRSCYYNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKX2</accession>
    <name>D7VKX2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">L-lysine 6-transaminase</fullName>
            <ecNumber evidence="2">2.6.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Lysine 6-aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lat</name>
        <name evidence="7" type="ORF">HMPREF0766_11641</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + L-lysine = (S)-2-amino-6-oxohexanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21200"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="EC" id="2.6.1.36"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.36" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999593.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11641"/>
    <dbReference type="EnsemblBacteria" id="EFK58245">
        <property type="protein sequence ID" value="EFK58245"/>
        <property type="gene ID" value="HMPREF0766_11641"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_1_10"/>
    <dbReference type="OrthoDB" id="572533at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045484">
        <property type="term" value="F:L-lysine 6-transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017657">
        <property type="entry name" value="L-lysine_6-transaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03251">
        <property type="entry name" value="LAT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="431" mass="49185" checksum="3DFD622DA6305964" modified="2010-10-05" version="1">MIKEATVHERLAKHILADGLPLVIDLEKSHDSYIVDIEGNEYLDMFSMFASSPIGYNHPHIVKNSDLLKKVAINKLALSDIYPREFADFVDTFERVAIPAELSYCFFIDGGALAVENALKAAFDWKTRLNISRGIQQEASEVIHFKQAFHGRTGYTLSLTNTKDPRKYMYFPKFDWPRITNPKLHFPLTEESVTETIKAEQQAIQEIEAAIAKNPDAIACLILEPIQAEGGDNHFRTEFFQELRRICDDHDILLILDEVQTGLALTGKMWAYEHYGIIPDLISFGKKSQVCGVLAHREKFDRVEKHVFKESSRINSTFGGNLVDMMRFKLILEVIEQENLVQQAESLGEYLLEKLEQLAKRHSQLSNVRGKGLLASFDFQTEQQRDEFVKRAMNNKLLILGCGDKSIRFRPHLTVTVEQLDKALALVEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL19</accession>
    <name>D7VL19_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_11688</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0324 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999723.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11688"/>
    <dbReference type="EnsemblBacteria" id="EFK58292">
        <property type="protein sequence ID" value="EFK58292"/>
        <property type="gene ID" value="HMPREF0766_11688"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2855">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033541_6_0_10"/>
    <dbReference type="OrthoDB" id="1856009at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018383">
        <property type="entry name" value="UPF0324_pro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30106">
        <property type="entry name" value="PTHR30106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03601">
        <property type="entry name" value="Cons_hypoth698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="417" mass="45583" checksum="513542D7AC360A0C" modified="2010-10-05" version="1">MDNQKFQFSEDWVVVILGLGIIALALSGIIIPTPKFSWSDLSSLQHDVLNFENIRAIFFQFAAVYGTAIVGAILLSKPLKALLIVFPVVFVLTVLALIAAGNAVVKDYNLEAVIFSLVIGLVISNFFKLPQWFKDALSTELYVKIGLVLLGTTVIFGDILKAGSLGLIQALVVVLSVWYFAFWLCKKLKIDNEMSLMISSAVSICGVSAAIATSGAIKGDSKKLSYVISLVLITAIPMMIFMPYMASWMGLSQEVTGAWLGGSIDTTGAVVASGSLVGEEALKISTIVKFSQNVLLGIAAFAISIYWSYSKSVNEETKQEKPTLKVIWERFPKFVIGFIFASLLFSFVISPEKVDTVKGSLKSLQGLWFALAFTSIGLETNFKDLFKQDNKKPLYAFLIAQTFNIIVTLLIALVLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL25</accession>
    <name>D7VL25_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_11694</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999735.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11694"/>
    <dbReference type="EnsemblBacteria" id="EFK58298">
        <property type="protein sequence ID" value="EFK58298"/>
        <property type="gene ID" value="HMPREF0766_11694"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_2_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107359" evidence="5">
        <location>
            <begin position="41"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="231"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="497"/>
            <end position="1121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1124" mass="124000" checksum="6C207D9AB59C5977" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLJ5</accession>
    <name>D7VLJ5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11865"/>
    <dbReference type="EnsemblBacteria" id="EFK58468">
        <property type="protein sequence ID" value="EFK58468"/>
        <property type="gene ID" value="HMPREF0766_11865"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1915765_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="132" mass="15309" checksum="89CAF37078D8977C" modified="2010-10-05" version="1">MFSPYFFCFDSVKYFFGSFGIIPKSGCKCQFLFLIDLFFLDINVKDASSGMLHDPSSLEYVLWSCIKSKDLKVLSHLSGLLTFLNLVFFVFQRALRKGNMFVFHLIGRGNLLSLNKYKSYVTKNRFYADKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLP3</accession>
    <name>D7VLP3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000282.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11913"/>
    <dbReference type="EnsemblBacteria" id="EFK58516">
        <property type="protein sequence ID" value="EFK58516"/>
        <property type="gene ID" value="HMPREF0766_11913"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z80K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027065_0_0_10"/>
    <dbReference type="OrthoDB" id="1230371at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="596" mass="68568" checksum="D1F02A3BF0844D6F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLQ6</accession>
    <name>D7VLQ6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative gliding motility-associated lipoprotein GldD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000308.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11926"/>
    <dbReference type="EnsemblBacteria" id="EFK58529">
        <property type="protein sequence ID" value="EFK58529"/>
        <property type="gene ID" value="HMPREF0766_11926"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZRB2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118000_0_0_10"/>
    <dbReference type="OrthoDB" id="1779336at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107293" evidence="1">
        <location>
            <begin position="23"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="194" mass="22998" checksum="7B0CE5F9DE9C9D3A" modified="2010-10-05" version="1">MRYFVLYLLSAFLFSAIFTACHEDYSPKPRGYFRIEFPDKKYKMTQTGCPFDFEIPAYATLDKDREKDAKPCWLNLDFPQFNARLHLSYFDINKNVSFQQLSEDARTFAFNHTVKATAIEQKRINKEDRRIFGVQYLIRGNTASNDQFFVSDSIHHYLRGALYFNEKPHLDSIQPVLDFINADIERIIQTIHWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLR3</accession>
    <name>D7VLR3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">coaBC</name>
        <name evidence="7" type="ORF">HMPREF0766_11933</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000321.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11933"/>
    <dbReference type="EnsemblBacteria" id="EFK58536">
        <property type="protein sequence ID" value="EFK58536"/>
        <property type="gene ID" value="HMPREF0766_11933"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033319_0_1_10"/>
    <dbReference type="OrthoDB" id="1346419at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="6"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="186"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="191"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="402" mass="43465" checksum="A71DF3382CFC5DDE" modified="2010-10-05" version="1">MSLQGKNIVIGVCGSIAAYKIATLVRLLVKEKAAVQIIMTPDAVEFITPLTLSTLSNKPVLVDYFDKKTGSWNNHVHLGLEADLLLIAPATANTLAKMANGQCDNLLTAVYLSAKCPVFVAPAMDLDMWKHPATQRNITLLKSYNNTIIHPGNGELASGLTGEGRLAEPEEILAYLSNYFTRSQPLSGRKALVTAGPTHEAIDPVRFIGNHSSGKMGYAIAEELKNLGAQVTLVSGPTHLSAPGDVNRISVISASQMLEAANTYFDAADIIVMSAAVADYTPETVADQKIKKKEDTFAIPLKKTTDILATLGKRKTDKQVLIGFALETNNELENAKGKLQKKNLDYIVLNSMQDKGAGFSTDTNKVTIIAKDGTLKEFSLKTKQEVAKDICNIIIRHPYPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLU7</accession>
    <name>D7VLU7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001597.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12201"/>
    <dbReference type="EnsemblBacteria" id="EFK58209">
        <property type="protein sequence ID" value="EFK58209"/>
        <property type="gene ID" value="HMPREF0766_12201"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2425426_0_0_10"/>
    <dbReference type="OrthoDB" id="1639867at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="91" mass="9903" checksum="1946E201AFDF7083" modified="2010-10-05" version="1">MSQYKIGTTLTGQTVKETTKAVTREIVKDAKGNLTDGVYTVSKEAMKKHVVGGVQGKSIFYPTLDPEQAVLKAAQNKRQMSLGHGLEIKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLW7</accession>
    <name>D7VLW7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11964</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK57972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001058.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11964"/>
    <dbReference type="EnsemblBacteria" id="EFK57972">
        <property type="protein sequence ID" value="EFK57972"/>
        <property type="gene ID" value="HMPREF0766_11964"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2913">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_3_1_10"/>
    <dbReference type="OrthoDB" id="554994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="21"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="347"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="475" mass="53293" checksum="9A38A9597CF6F6F6" modified="2010-10-05" version="1">MRSYLYIFIGFIICSLTACESYLDAGPPKDQMPSELAFSDDKTATASVTGVLSRMNQLNYQFANVLSMILPAMSADEFVYAVASAPYDEFKNNAVLSSNSNVTTLWSQPYTYIAQANLCVEGLEASTNLSPKVKSQLLGEAKFIRAFCYFYLVNYFGDVPLIRGTNVMENNTKPRTPQAEVYAAIIEDLKDAKAKIFQGYPQVDKADANGERIRANKSAASALLARAYLYTKQWDLAEQESSEVLGATQYKLQPTADLDKVFQANNQEAIWQLQVVNTAGGRNTWEGFLIVPAAPTSAPLFRLIPGYLYDAFENGDQRLTRWVGSMTTAAGVTHRYPYKYKIRTGVTPAKEYTMVLRLGEQYLIRAEARLMQSKWGLAQEDINVIRNRAGLQSLSLGNDAVALRKALEQERRVELFGEWGHRWLDLRRWPSETGQEGKTRADDILPALKPKWQSKAIYFPLPDVALRTNPNLVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLY9</accession>
    <name>D7VLY9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 4-hydroxybenzoate polyprenyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_11986</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK57994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001124.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11986"/>
    <dbReference type="EnsemblBacteria" id="EFK57994">
        <property type="protein sequence ID" value="EFK57994"/>
        <property type="gene ID" value="HMPREF0766_11986"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034879_5_1_10"/>
    <dbReference type="OrthoDB" id="1472516at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006371">
        <property type="entry name" value="HB_polyprenyl-transferase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PTHR11048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01475">
        <property type="entry name" value="ubiA_other"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="284" mass="32095" checksum="4A2300BE91FA46BD" modified="2010-10-05" version="1">MKKYFSLVLFAHSVFALPFALIGFFLAVHTTSYSFEWIKLVLMLVCMVTARNAAMAFNRYLDRDIDAKNPRTVMRDIPAGRISARQALLFTIINCAIFTGATYLINPLCFYLSPIALFVVLFYSYTKRITPLCHLVLGVGLGLAPIGAYLVVTGQFNIIPVFYGIAVMTWASGFDIIYALQDEEFDRANNLNSIPVRLGTKNALRVSECLHVISFIFVVLPAFYMHVSWFYYLGLAFYGLLLIYQHRIVSPTDLSKVDRAFMTTNGIASVIFAVFYLLDVIFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM77</accession>
    <name>D7VM77_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">lgt</name>
        <name evidence="3" type="ORF">HMPREF0766_12074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001359.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12074"/>
    <dbReference type="EnsemblBacteria" id="EFK58082">
        <property type="protein sequence ID" value="EFK58082"/>
        <property type="gene ID" value="HMPREF0766_12074"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013386_1_0_10"/>
    <dbReference type="OrthoDB" id="435911at2"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="276" mass="32106" checksum="BC3584C79770CE06" modified="2010-10-05" version="1">MENLFNIIYWDIHPEIFKIGSFGLRYYALCWLAAFAISYVLMLKIFKREGKTQEQLDQLSIYIFLGTLIGARLGHCLFYEFDYYKDHIMEIFLPFRWDANGNFQMTGFAGLASHGAAVGILTSIYLFARKTKINFMWVADRLVIVVPIAGAFVRLGNFFNSEMIGPPTDLPWAVVFKNIDNIPRHPGQLYEALAYVIIFIVMWYLYNKKSILKPGYLFGIFLVLLFGARFVLEYFKIDQEDFEKNMLFNMGQILSIPFILAGFYLIFRKPKEGQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM87</accession>
    <name>D7VM87_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter, DASS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_12084</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001370.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12084"/>
    <dbReference type="EnsemblBacteria" id="EFK58092">
        <property type="protein sequence ID" value="EFK58092"/>
        <property type="gene ID" value="HMPREF0766_12084"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0471">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005170_7_3_10"/>
    <dbReference type="OrthoDB" id="626718at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030676">
        <property type="entry name" value="CitT-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42826">
        <property type="entry name" value="PTHR42826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002457">
        <property type="entry name" value="DASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00785">
        <property type="entry name" value="dass"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="476" mass="51629" checksum="A3F369447B09EEC4" modified="2010-10-05" version="1">MKEINIKNVCITFIVAIIIWFIPIPKGVTPEAWHLFAIFAATILGIILKAAPMGTMCMMAIGFTALTQVLAPGNASASIVKSLSGFGDKVIWLIGISFFIARGFIKTGLGNRIAFLFIKVFGKSSLGLAYGLGLADVCLAPAIPSNTARGGGIIYPIMKSMAISFGSMPDDPKTHRKLGAFLTLNSYYMNLIASSMFLTGTASNPMCQKFAANLGIDITWMSWAIAGFVPGAVAFFIVPLVLYKLFPPELKKTGDAPKMASEKLKEMGPVKKNEWLMLLAFFILLFLWIFGGSLSIDATTTAFIGLTLLLLTSVLTWEDVKSEKGAWDTIVWFAVLVMMASSLNELGFIGWFSDLIKVQIGGLNWLVAFPVIILVYFFSHYIFASATAHVAAMYAALLGVGVSLGIPPMLLAMMLGFMGSIYGVLTHYGHGPAPVFFGSGYVELKAWWLRGLEIGIVLLIIYMAVGGLWMKVIGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMA0</accession>
    <name>D7VMA0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5008 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001394.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12097"/>
    <dbReference type="EnsemblBacteria" id="EFK58105">
        <property type="protein sequence ID" value="EFK58105"/>
        <property type="gene ID" value="HMPREF0766_12097"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_507966_0_0_10"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013431">
        <property type="entry name" value="Delta_60_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032175">
        <property type="entry name" value="DUF5008"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16400">
        <property type="entry name" value="DUF5008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17164">
        <property type="entry name" value="DUF5122"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107427" description="DUF5008 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5008" evidence="2">
        <location>
            <begin position="20"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="537" mass="57174" checksum="03DDFBCAF840BE28" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMB0</accession>
    <name>D7VMB0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Stearoyl-CoA 9-desaturase</fullName>
            <ecNumber evidence="8">1.14.19.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_12107</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="7">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.2" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001415.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12107"/>
    <dbReference type="EnsemblBacteria" id="EFK58115">
        <property type="protein sequence ID" value="EFK58115"/>
        <property type="gene ID" value="HMPREF0766_12107"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034505_0_0_10"/>
    <dbReference type="OrthoDB" id="644190at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045300">
        <property type="term" value="F:acyl-[acyl-carrier-protein] desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102786">
        <property type="term" value="F:stearoyl-[acp] desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01050">
        <property type="entry name" value="Acyl_ACP_Desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005067">
        <property type="entry name" value="Fatty_acid_desaturase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31155">
        <property type="entry name" value="PTHR31155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03405">
        <property type="entry name" value="FA_desaturase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000346">
        <property type="entry name" value="Dlt9_acylACP_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000346-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="331" mass="38366" checksum="9058F44B10E6CEEA" modified="2010-10-05" version="1">MQELNQQIPEGSRKEVMTYLEPFMLNEMSEYLKPVEEMWQPADFLPDASRDTFFEEVRDLQESAKELSYDLVAVLIGDTLTEEALPTYESWLTMVDDVEKNEQGGWMKWVRAWTAEENRHGDLLNKYLYLTGRVNMKEFERSAQYLIQDGFDIGTGRDPYRNFIYTSFQEIATNVSHRRVAGLAKKHGDKLLAKMCGVIASDEARHAKAYMSFISQALVVDASEVILAFEDMMRKKIVMPAQFLRESGEPQGEAFAHFSDAAQRLGVYTAIDYVDILKELNTDWNIDKLTGLNEQAEKARDYLLKLPDRLLRLADRMKTPLKEYKFKWIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMS7</accession>
    <name>D7VMS7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7 8">Elongation factor Tu</fullName>
            <shortName evidence="7">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">tuf</name>
        <name evidence="10" type="ORF">HMPREF0766_12297</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992774.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12297"/>
    <dbReference type="EnsemblBacteria" id="EFK57224">
        <property type="protein sequence ID" value="EFK57224"/>
        <property type="gene ID" value="HMPREF0766_12297"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_0_0_10"/>
    <dbReference type="OrthoDB" id="621774at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK57224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="394" mass="42938" checksum="D7C0027FCD962A81" modified="2010-10-05" version="1">MAKEKFDRSKPHLNIGTIGHVDHGKTTTTAAITKVLADAGLSEARSFDSIDSAPEEKERGITINTAHVEYQTANRHYAHVDCPGHADYVKNMVTGAAQMDGAIIVVAATDGPMPQTREHILLARQVGVPALVVFLNKVDLVDDSELLDLVEMEVRELLSFYEYPGDDIPVIKGSALGALNGEQQWVDSIMELMDAVDNYIPIPPRLTELPFLMPVEDVFSITGRGTVATGRIERGVINSGDPVEILGMGAENLKSTVTGVEMFRKILDYGEAGDNVGLLLRGIEKTDIRRGMVICKPGSVTPHDNFKAEVYVLSKAEGGRHTPFFNKYRPQFYFRTTDVTGEITLAEGTEMVMPGDNVTITVKLISPIAMEKGLRFAIREGGRTVGAGQVTEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMY9</accession>
    <name>D7VMY9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit c</fullName>
            <shortName evidence="13">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">atpE</name>
        <name evidence="15" type="ORF">HMPREF0766_12359</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992877.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12359"/>
    <dbReference type="EnsemblBacteria" id="EFK57286">
        <property type="protein sequence ID" value="EFK57286"/>
        <property type="gene ID" value="HMPREF0766_12359"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148047_5_0_10"/>
    <dbReference type="OrthoDB" id="2078221at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="14">
        <location>
            <begin position="7"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="13">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFK57286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="63" mass="6155" checksum="AF7013047C2554E7" modified="2010-10-05" version="1">MIPNLVGAGLIVIGAGLGLGKIGGSAMEAIARQPEAASKIQTAMIIIGALVEGLAFGALILGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN03</accession>
    <name>D7VN03_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12373"/>
    <dbReference type="EnsemblBacteria" id="EFK57300">
        <property type="protein sequence ID" value="EFK57300"/>
        <property type="gene ID" value="HMPREF0766_12373"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3239794_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="43" mass="4844" checksum="B8E18B0C033E5D74" modified="2010-10-05" version="1">MTIIGKTFITFAAACVYGNLFLSLLEDKIIRILVPCINIYFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN43</accession>
    <name>D7VN43_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992950.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57340">
        <property type="protein sequence ID" value="EFK57340"/>
        <property type="gene ID" value="HMPREF0766_12413"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1516997_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="177" mass="20681" checksum="EA24F3B1BD14C515" modified="2010-10-05" version="1">MDYEKLDDILDFLRRSQGYAGWASYTQDVARRQNVHFDTINNSTSYAGWCNTLLHFGLVDYKFDANLLHTYIINPKGLDLLNNEKSTLDVHQEYINKEILEGAILKQTNQSFKLNNIQFIITAILTLGTLGSLIIQWKTFEMEKDKTKLEIRDLQYRLDSIQKPNNFKIDNKNIKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNG7</accession>
    <name>D7VNG7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993112.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12537"/>
    <dbReference type="EnsemblBacteria" id="EFK57464">
        <property type="protein sequence ID" value="EFK57464"/>
        <property type="gene ID" value="HMPREF0766_12537"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50331PZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112450_0_1_10"/>
    <dbReference type="OrthoDB" id="1973876at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107154" evidence="1">
        <location>
            <begin position="25"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="151" mass="17671" checksum="901E80BC85E99825" modified="2010-10-05" version="1">MMLQLKKILAACCFVFLLTLSAHAQRDNERFKAIENEKIAYITKELNLSSSEAQQFFPLYNEYSQEMWAIRNEKIGPRQSAPSRSNGFRQGGSRDVIAYDAKELEIKKEYRAKFARIIGNSRASQFFEIEQNFIELLYKEWQSRKNGSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNH3</accession>
    <name>D7VNH3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993118.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12543"/>
    <dbReference type="EnsemblBacteria" id="EFK57470">
        <property type="protein sequence ID" value="EFK57470"/>
        <property type="gene ID" value="HMPREF0766_12543"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026375_2_0_10"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="243"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="443" mass="51288" checksum="F2C6DC9A7C3DD077" modified="2010-10-05" version="1">MNGKLSRLILTFSILFIVLVGIQVYFISNTYQLKRREIIEDVKQSLSSLEDDVDIFDKSLLKDNEAQEAVWKVEKKQWTESDLRSLYARKAKSVEAKLTRYVDSTFAEKGYKVGVMKEFVNVISRSTNRPLIQHPLLIYKTSTPVSKKYLMTSGKWETSYNSTTTTDDKKTKISSQRKYSYHLVRKTYFEINNLKWVVFKDLLFLIITSLLILTAVLILFYLTYKNLLRQRKQIDVLHDMMDNISHELKTPIATLKIASKTLAHNTDSQVVQVIGRQVDRLENMLQPIMQQERRDELTYWTIADAKAFVSDFQLAHPMITLEVEQLFDHDLKLDKYDIETILTNLLNNSIKYGAKSVSLSFELNEGLVKIVVKDDGVGIDKLEQPYIFEKFYRIQKDNIHDTKGLGLGLYIVKQIVSKYKGEVTVLSELSKGAAFRISLPYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNW9</accession>
    <name>D7VNW9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Urease subunit gamma</fullName>
            <ecNumber evidence="4 5">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Urea amidohydrolase subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">ureA</name>
        <name evidence="6" type="ORF">HMPREF0766_12689</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4 5">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the urease gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="4 5"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993333.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12689"/>
    <dbReference type="EnsemblBacteria" id="EFK57616">
        <property type="protein sequence ID" value="EFK57616"/>
        <property type="gene ID" value="HMPREF0766_12689"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0831">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145825_1_0_10"/>
    <dbReference type="OrthoDB" id="1826954at2"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00739">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012010">
        <property type="entry name" value="Urease_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001223">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="SSF54111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK57616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="100" mass="11420" checksum="ACA489A4192F9D19" modified="2010-10-05" version="1">MHLTPRETEKLMLHLAGELAAKRLKRGVKLNYPESIAYISAELMEKARDGKSVAELMEWGTRLLKRKQVMEGVPEMIHDVQIEVTFPDGTKLVTVHNPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNY2</accession>
    <name>D7VNY2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993352.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12702"/>
    <dbReference type="EnsemblBacteria" id="EFK57629">
        <property type="protein sequence ID" value="EFK57629"/>
        <property type="gene ID" value="HMPREF0766_12702"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098671_1_0_10"/>
    <dbReference type="OrthoDB" id="1983082at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="167" mass="19427" checksum="F232906D06AF5948" modified="2010-10-05" version="1">MNKDLIIKRVSEQDIDELITYVSQARKLLFPMLDHRKMPHDLQYFAQTYIHSPVGAFLEARDHRGDLMAVIGMMTYDQRFPFLHLEQENTVEVVRLYVNPKGRRKGIATALFQELVEVAKAQAVSTLYLHTHPFLTGAYEFWLQCGFQTLVRKDHSGFATIHMKCEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP06</accession>
    <name>D7VP06_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12726"/>
    <dbReference type="EnsemblBacteria" id="EFK57653">
        <property type="protein sequence ID" value="EFK57653"/>
        <property type="gene ID" value="HMPREF0766_12726"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9VV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046382_0_0_10"/>
    <dbReference type="OrthoDB" id="818419at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="293" mass="32996" checksum="C183074CFF631C75" modified="2010-10-05" version="1">MYKYIITGIGILLAGCGSIKKNTMPLDNAGITSSDVRFFKGEIRPEQAKACFEGAYYRKLVSSEDNWVGIEGKVLLPQLEFDKTRINPKKSKQYLDNPSVYLGGCMDGQETDIGLSWEVIKDERGVVSEERKAFRPFMRRTGHGTEQAAVFVNAPAIKDYYWYPGEEVHMSVVLIRDGLLRFVVEGAGKKFEYDFECAGYTFGRKGEFKRVNAIDQMSNEGKPAQATTTKVKGSRWFYTNLIRHEMGALVAVPFHEERYTEMACPKAEYFDIVSAKEWTAKGGEEISISGAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPH0</accession>
    <name>D7VPH0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Redoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993700.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12890"/>
    <dbReference type="EnsemblBacteria" id="EFK57817">
        <property type="protein sequence ID" value="EFK57817"/>
        <property type="gene ID" value="HMPREF0766_12890"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131488_0_0_10"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107487" evidence="1">
        <location>
            <begin position="18"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="20"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="160" mass="18563" checksum="EF2CC1ED91ABAAAB" modified="2010-10-05" version="1">MKKLIVILLSVYFTSHAAAQKAPVTIPDFTFYLLQNNQPFKQDKLPSSGYIVFNYYDPGCGHCQKMAAGIAKNIDKFSKTQIYFVTINDKPYVDGFIEMYIPALKNRKNVVFLHDKDIEFIPKFNPTQYPSVYLYDAKTRKLIKHFDGEEDARKLVTYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPM7</accession>
    <name>D7VPM7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="9">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">asnB</name>
        <name evidence="9" type="ORF">HMPREF0766_12947</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="9"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993807.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12947"/>
    <dbReference type="EnsemblBacteria" id="EFK57874">
        <property type="protein sequence ID" value="EFK57874"/>
        <property type="gene ID" value="HMPREF0766_12947"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014658_2_2_10"/>
    <dbReference type="OrthoDB" id="610569at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="347"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK57874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="563" mass="63162" checksum="8107E0E422BCD8E1" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPQ3</accession>
    <name>D7VPQ3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiazolinyl imide reductase</fullName>
            <ecNumber evidence="3">1.1.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">idh</name>
        <name evidence="3" type="ORF">HMPREF0766_12973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.18" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993848.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12973"/>
    <dbReference type="EnsemblBacteria" id="EFK57900">
        <property type="protein sequence ID" value="EFK57900"/>
        <property type="gene ID" value="HMPREF0766_12973"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_778099_0_0_10"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050112">
        <property type="term" value="F:inositol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="152"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="357" mass="39819" checksum="87531A2F315DA18C" modified="2010-10-05" version="1">MQKIKILVVGCGNMGASHAQAYHELPDFEIVGLVSRGDSKRELNVRLNASYPLYEDYAEALADSKPDAVCIATYPDTHETYAVMAFDSGAHVFIEKPLADTVTGAERVIAAAERSGKKLVVGYILRHHPSWIKFIETGRQMGYPLVMRMNLNQQSQGYMWDVHRNLMKSLSPIVDCGVHYIDVMCQLTDARPVQVSAIGARLTNDIPEDNYNYGQLQIRFDDGSVGWYEAGWGPMMSETAFFVKDVIGPLGCVSIVANEASGSGHSDSVASHTRTESLRIHHAAIDDQNKFVRKDEWIHLEDEPDHQELCNREQLFFLKAIRENPDLSKSMQDALNSLRIAIACDESVKTGQMVSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPX2</accession>
    <name>D7VPX2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mg2+ transporter-C family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mgtC2</name>
        <name evidence="8" type="ORF">HMPREF0766_14332</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MgtC/SapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996454.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14332"/>
    <dbReference type="EnsemblBacteria" id="EFK57129">
        <property type="protein sequence ID" value="EFK57129"/>
        <property type="gene ID" value="HMPREF0766_14332"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079292_0_0_10"/>
    <dbReference type="OrthoDB" id="2022224at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK57129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="234" mass="25454" checksum="D5AA67174A2A7675" modified="2010-10-05" version="1">MNTLDFTIRLALSLLLGASIGFERQWRQKSAGLRTNTLVSLGSTAFILLSVSIGGDATGRVASYIISGIGFLGAGVIMKDGMSVQGLNTAATIWCSAAIGSLVGVGLYAEAVILSFFVVLIHLLMRPLGQRIGQSHFIKSSLIQTDYRFSIICRAEVENHIRILLLQQLGNHEKLLLKSLSSDDYENPQKAIITAEIHAASQQDSFMERVASLLTIEEKVMKVSWEIIGTQSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ56</accession>
    <name>D7VQ56_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rimP</name>
        <name evidence="6" type="ORF">HMPREF0766_13110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994055.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13110"/>
    <dbReference type="EnsemblBacteria" id="EFK55907">
        <property type="protein sequence ID" value="EFK55907"/>
        <property type="gene ID" value="HMPREF0766_13110"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0779">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070525_3_1_10"/>
    <dbReference type="OrthoDB" id="1595498at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036847">
        <property type="entry name" value="RimP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74942">
        <property type="entry name" value="SSF74942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="DUF150" evidence="4">
        <location>
            <begin position="21"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="DUF150_C" evidence="5">
        <location>
            <begin position="89"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK55907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="156" mass="17716" checksum="6CA22BBA7E6F825B" modified="2010-10-05" version="1">MKTKVEKRVEELVLEKIGDREDLFIVSIKMQSNGVLEILVDGDSGIAIDDCVKISRHVGFHLEEENVIETAYRLEVSSPGIDSPLIMIRQYKKNIGRNVRVKNHEGEKREGKLLNVTESNITIEESKKEKGKKAVPVESVIPFEQIKETKVLISFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ69</accession>
    <name>D7VQ69_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_13123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994072.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13123"/>
    <dbReference type="EnsemblBacteria" id="EFK55920">
        <property type="protein sequence ID" value="EFK55920"/>
        <property type="gene ID" value="HMPREF0766_13123"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052307_1_0_10"/>
    <dbReference type="OrthoDB" id="1585225at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK55920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="342" mass="38616" checksum="56142EC72759B1E2" modified="2010-10-05" version="1">MASKIYKIIFFILGLGTLGYMVYSLGPEVIWENIEKTGWWFIPVLLSWLVIYLMNAMALRDILLEKDNPKTRLPFGKIFQLIVTGFSINYITPFVALGGEPYRIMELKPYVGNSKAGSSVLLYTMMHILSHLVFWVASVGLILWFVPASKIVVIACVTIILMAVLGVWWFSKGYKKGITVSLMKSLSKLPFVGKKIALYEQEHHELLTDVDNQVRSLYVDRKRNFYTSLCWEFFARVVGCAEIYFIAHALGLPMTYVECLIVSSGSSLFANLIFFFPMQLGTREGGMAMAVASVGYQASVGVFIGIATRIRELVWIAIGLLMMSFARRSKTKREAQLNDSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ72</accession>
    <name>D7VQ72_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Redoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13126"/>
    <dbReference type="EnsemblBacteria" id="EFK55923">
        <property type="protein sequence ID" value="EFK55923"/>
        <property type="gene ID" value="HMPREF0766_13126"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_1_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107435" evidence="2">
        <location>
            <begin position="20"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="325"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK55923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="471" mass="53825" checksum="42DE113571286F6E" modified="2010-10-05" version="1">MKKITLILLLCLYTSLVIAQQKTATITVDLEGGLKLDSIRLFKYDSYNLYAKPDAGSKYKFEIKDKLPIGVIINGPKDKQIYAFLESGEDLQLKTDFDQKIVFSGKDAANSTVLNNYMKALDNFNKKINYTNMSVPTQIMDTVYKADQIPIDLLMANKAKVTPGFYNFQKVNLEYELLQDKAWTSYMVAHQKKDKFKMSEGLPPDFADLIKQVKFDDQLLNIPNYRYLLTVYYPSYLHRREIMLAGKMDSPHELKDALNEYKMILKYYPAGMIRDEAFKICIRQVLDQAKDVSLTKPTIDDYIAKYASAAEAGEILDEYNRKLKMSAGQMAPAFSLKSLDGKEVSLQDFKGKVVYIDFWASWCGPCRYEMQNGSPKLHARFKDIKDVVFLYVSFDSKVDDWKKAIADDKIEGIHLLSQARSGLDTPIAKAFNINGIPHYVIIDKEGRIFDNNASRPSENGTEARIREALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ85</accession>
    <name>D7VQ85_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13139"/>
    <dbReference type="EnsemblBacteria" id="EFK55936">
        <property type="protein sequence ID" value="EFK55936"/>
        <property type="gene ID" value="HMPREF0766_13139"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042767_1_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="1">
        <location>
            <begin position="56"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="181" mass="21016" checksum="CB28BCE0395FEAA3" modified="2010-10-05" version="1">MDNYPISAHLLGLLFQLDGKQLQEQYKNHLSDFHDWDQKHHAECWIVFPENISEQLSIDETSLSNGELYTIVSSKASKGRKGTLLATISGTKAEDIIAVLERIPLRLRNKVREVTMDLAPNMAKAIRRCFKNARRVIDRFHGQKLAYDAVQELRIRYRCKVLDEESKKITRSTKKRYSLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ96</accession>
    <name>D7VQ96_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipocalin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994114.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13150"/>
    <dbReference type="EnsemblBacteria" id="EFK55947">
        <property type="protein sequence ID" value="EFK55947"/>
        <property type="gene ID" value="HMPREF0766_13150"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109259_2_1_10"/>
    <dbReference type="OrthoDB" id="1979306at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024311">
        <property type="entry name" value="Lipocalin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13924">
        <property type="entry name" value="Lipocalin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="162" mass="18376" checksum="19E6EBBFD46D392C" modified="2010-10-05" version="1">MTSVKNELVGSWKLLSYIELPIDGSDSLFPVGKNPEGILMYSPDGFMSVQIMAQDRPPLVSGDRFAATQEESLAVINTFIAFSGAYQILENRVVSYQIKTSLFPNWAGQTQERIFDFEGDVLYLKSTEPILSNGVMVNSYMTWQKHKKAQYKEAQLERQTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ99</accession>
    <name>D7VQ99_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994120.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13153"/>
    <dbReference type="EnsemblBacteria" id="EFK55950">
        <property type="protein sequence ID" value="EFK55950"/>
        <property type="gene ID" value="HMPREF0766_13153"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032Y9I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048279_0_0_10"/>
    <dbReference type="OrthoDB" id="909035at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK55950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="456" mass="49118" checksum="D996952368375BB5" modified="2010-10-05" version="1">MAKENKKELIDDIADKLRDYELPYREGAWEKFASLDKGRKSRVLWPYWSAAAVILALGISYITYNTGDLQGDNAGVNTIAKKENTTQHAMPGAGQDSPSAPVESSDANVNQVHPNITNSSSKGLENRLASLSDPQQHTTTYIAADQSARVSVPFNELRTAALSADPIRAKESDLPDKTGTGLSRYNGLSGIKADDEPQPESKFSLSVLGTDNQQQTLANQQINRPKGMGRKWELGAFVSPASASSEVSMGGGLSVAYNLTKKLSVRSGVAVQNYQMAMALNPGKPSSASPAYMDSPVSNNAYLIDMSSAQSRLNPNFTAVSGSVLTLDIPVEMKYAITRNLYTTAGVSMVSVLQQERLNHYVENINGNTFAGKNANGVGAAESNNIQAVNKTVKSNEQNVGTNGFNGFINLSIGRKLPIKKTFSISVEPFYRLPLGQFKNSDVNYSNGGIKVITNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQC8</accession>
    <name>D7VQC8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994199.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13182"/>
    <dbReference type="EnsemblBacteria" id="EFK55979">
        <property type="protein sequence ID" value="EFK55979"/>
        <property type="gene ID" value="HMPREF0766_13182"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043019_2_0_10"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107146" evidence="3">
        <location>
            <begin position="22"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK55979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="389" mass="42952" checksum="5D5AD7D7827D941A" modified="2010-10-05" version="1">MNIKRTIVLSVLLSAGTFVFAQTGNLKKAKAAIAKFEELKGAGQAKLGESNLKTASEAINEAIAHEKTKDLAETWTYYALVNANYASMNNSAEDAQKAEEGIKKATELDTDKKNADNIKVATQILGQYNFNQGVAAWEKQDFQTAYKAFDKGLVYLPGDTTLTYYSGLAAIQNKDYKSAIDKYKLLIPEKNFSNHKSVLVDLPKLYLSALDTASALEYASIAAKEYPTDNAAAVQNIELNLIAGNEQKIVTDIESQLAKDPTNKTLYYYLGIARSATKETDKALEAYKKAIELDPNYFEANTNAAVTIMNLVREDINKANNDRSLKPAEYNAAVAAAKDKLKPALPYLLKLVELEPKNVDSLKYLKSYYDFIQDEAKSKEVQAKIDALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQD6</accession>
    <name>D7VQD6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter, small conductance mechanosensitive ion channel MscS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_13190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13190"/>
    <dbReference type="EnsemblBacteria" id="EFK55987">
        <property type="protein sequence ID" value="EFK55987"/>
        <property type="gene ID" value="HMPREF0766_13190"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_952277_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK55987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="304" mass="34405" checksum="6A6B2F9B85596C70" modified="2010-10-05" version="1">MLKKGAKLFSLAAQVNISMQDYSKKGKWPIVFIVKVVVWLALILSFPILQDVYKRSTYLSQIAYALNTFLTASVLFSVGRFVMIALYTRRTERQSVRGNFVLGINRVTAVLNSIFAIIALMLAFGINPVGFVTSMTIVAMAIAVTFREYITNMISGLILMFSDQFSIGDRIKVGEYHGKIVDITLANIVVKNDEDDIVLIPNNAAFTEKIVNKSVNQSNKLSVKFELPLYAAANMEELEEKLKKLLMYHPDVHWTDDVALKVVNIGKDYVQYKIEFNALNSTNKLHRQLENEVLTLILKQQREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQK5</accession>
    <name>D7VQK5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gdhB</name>
        <name evidence="6" type="ORF">HMPREF0766_13259</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13259"/>
    <dbReference type="EnsemblBacteria" id="EFK56056">
        <property type="protein sequence ID" value="EFK56056"/>
        <property type="gene ID" value="HMPREF0766_13259"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012253_0_1_10"/>
    <dbReference type="OrthoDB" id="567019at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="398"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK56056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="502" mass="55610" checksum="0F0B08A2C7198549" modified="2010-10-05" version="1">MLRFNTFIIVAVIVFMASCGPKKLPENAEFVQLQQTVLSLTPEADSLDVPWDLQYDQAAHAIIFSEIAGKIKKLDLKTSKVENLITIPEVYHQRTLGLLGMALFQEKDSPSYLYLSYTSKSSDSIFSNLVRYDYSTTSKLSNPKTLLKIPGNTGHNGSRIIVTHDQKIIWATGDAASDTYAQDSTSLNGKILRLNPDGSIPKDNPIPGSYVYAWGFRNMQGLTQSPTGNIYTSEHGDAIEDEINLIRPLHNYGWPQIEGMHDTETEKAIAKKSPRTEPIRSWTPVIAPAGLAYYSNDAIPEWKNTLLLTTLKSQSLRILKLSDDGSRIVDEDIVFADKLGRLRSVMVLPDGDIYFCSSNRDWNPQKGFPKPADDVIYKLSKTDVRPVKTIKPTKPVAQTTKSGQELYKAYCASCHKDDGSGVPSSFPPLKQSALVNGAPEPLIHILLKGLTNQKTGKVQYEGAMPAFSFLRDEEIASIATYIRSNFNNQASAISATQVKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQK6</accession>
    <name>D7VQK6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13260"/>
    <dbReference type="EnsemblBacteria" id="EFK56057">
        <property type="protein sequence ID" value="EFK56057"/>
        <property type="gene ID" value="HMPREF0766_13260"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3066345_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="53" mass="6258" checksum="B9B5E64EB1411205" modified="2010-10-05" version="1">MSNFRFTGIYPQVKDKASIVESNVNINLRKSNNIVYNFKLYLFTILNMMLQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQM4</accession>
    <name>D7VQM4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994388.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13278"/>
    <dbReference type="EnsemblBacteria" id="EFK56075">
        <property type="protein sequence ID" value="EFK56075"/>
        <property type="gene ID" value="HMPREF0766_13278"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_2_10"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="191"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="303" mass="35378" checksum="62AA6533FDC0A109" modified="2010-10-05" version="1">MNKSESISEFYARVPQVSRELLPEAQSAGVGHFNVFTRDACSFLAPYSRRDFFKVSYIIGKGRLYFADQWIYIDKPALLLSNPKVPYAWEAESMDQKGWFCLFTDSFLNHDEKFKFFQQTPLFQTHIHPVFFPDEVQQQEISAIFKRMLVEINSGYLHKYDVLRSYLHVLVHEALKIQPPDTFVKHKDASARITQLFLELLERQFPIDTPEFRLQLHTPKEFAACLSVHVNHLNRSVKKETGKTTGELIATRILAEGKALLQHSNWSISEIAYSLGFESPAYFTNFFKKYQQQSPLEYRKNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQN2</accession>
    <name>D7VQN2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994396.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13286"/>
    <dbReference type="EnsemblBacteria" id="EFK56083">
        <property type="protein sequence ID" value="EFK56083"/>
        <property type="gene ID" value="HMPREF0766_13286"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029630_6_0_10"/>
    <dbReference type="OrthoDB" id="1564715at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="276" mass="29577" checksum="160DFD540CB343C6" modified="2010-10-05" version="1">MNLFNLFETITQVDPEFNERVSPRREAIKNMTSFGKKVTLAAMPFVLSELLKKAYGQVPTDVNGVLNYALTLEYLEAEFYTRGAAAANLVPAGKPMGAITTIRDHEVAHVNFLKTVLGNNAVAKPTFDFTAGGTFGNVFTNYDTFLALAQAFEDTGVRAYKGQAGILKGNRVVLTAALQIHSVEARHASHIRQMRRARGGAAADQKPWITGANDSGIGAVVDPIYAGEDNKVQGGVDITTLNAVNGKVSANAATQSFDEPLTAEAVLNIASLFIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQP3</accession>
    <name>D7VQP3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-70 region 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13297</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994412.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13297"/>
    <dbReference type="EnsemblBacteria" id="EFK56094">
        <property type="protein sequence ID" value="EFK56094"/>
        <property type="gene ID" value="HMPREF0766_13297"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_4_4_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="13"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="99"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="171" mass="20366" checksum="47A56824AC8C045B" modified="2010-10-05" version="1">MTQETFKSVVFIHKDKLFRFANRFLIDPQDAFDIVQEVLIKLWESRMELSKVSNVEAYAMRMTKNLSLNKINREAVKYKAESYEMPDIQKEKYPALTRDLILKLIDRLPEKQRLVMYLRDIEEYEFDTICELTGIDENAARVNLSRARNTVKNGLTMIFDYEERRIRAIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQS9</accession>
    <name>D7VQS9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994459.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13333"/>
    <dbReference type="EnsemblBacteria" id="EFK56130">
        <property type="protein sequence ID" value="EFK56130"/>
        <property type="gene ID" value="HMPREF0766_13333"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50337Z0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149369_0_0_10"/>
    <dbReference type="OrthoDB" id="1903250at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107811" evidence="1">
        <location>
            <begin position="23"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="141" mass="15913" checksum="732504EFBC8B8AC1" modified="2010-10-05" version="1">MKNAIKSIATALILVTSLSAFAGENTNPVKTNSVSTVKSFLEATTLGNLNFNNQLFAKDFEYYTVSKPNEKFNKNQYTEFLKNTKGLQYDCITSYQVLDENSDICVAKATMAFKNFTRVDYITLTRSQDVWKVSKVVTTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQZ3</accession>
    <name>D7VQZ3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994539.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56194">
        <property type="protein sequence ID" value="EFK56194"/>
        <property type="gene ID" value="HMPREF0766_13397"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033VYP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1407960_0_0_10"/>
    <dbReference type="OrthoDB" id="2140995at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107458" evidence="1">
        <location>
            <begin position="24"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="193" mass="22171" checksum="42282E08DE72AB03" modified="2010-10-05" version="1">MIRLYILKPMKKVLFLVIPILFACQSNSPANYPYSEKETKEFLDQISSNIMVLNSDLTLIHKKPAHEFDILTYYPLPKSKVEEYNKNGHIVNKMDDIADFATYEIKDYELINEKNEKLQLLEDISAPSLQDFSLWTYKDVLCGQLGIYVKLHKNFETLKGHITVLLAMPGGHTRTVKVPVNISITDKDPRPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR30</accession>
    <name>D7VR30_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_13434</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994596.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13434"/>
    <dbReference type="EnsemblBacteria" id="EFK56231">
        <property type="protein sequence ID" value="EFK56231"/>
        <property type="gene ID" value="HMPREF0766_13434"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013529_0_0_10"/>
    <dbReference type="OrthoDB" id="15185at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="206"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="433"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1002" mass="112393" checksum="B34B9BE19B0F43A4" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRC3</accession>
    <name>D7VRC3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994710.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13527"/>
    <dbReference type="EnsemblBacteria" id="EFK56324">
        <property type="protein sequence ID" value="EFK56324"/>
        <property type="gene ID" value="HMPREF0766_13527"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1474278_0_0_10"/>
    <dbReference type="OrthoDB" id="1282004at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="183" mass="21495" checksum="BED7528577BE26DC" modified="2010-10-05" version="1">MAEKHPELLNAYLAFSPVVNQTKSEQILLENLKLDAKEKANPEALKELNIVKIPFNSYEDMYYSRKWMLSYDGHPVAEKDLPLLKQYMEDWSKVWMPTWNEVMKHNLLVELPTIKCPVYFFLGEKDLQTNCNIARDYYNILKAPKKNIYTFKNAGHSVLVDEAEQVQKIIIAEIFKNDNNQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRD4</accession>
    <name>D7VRD4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Addiction module antidote protein HigA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">higA</name>
        <name evidence="1" type="ORF">HMPREF0766_13538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994723.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13538"/>
    <dbReference type="EnsemblBacteria" id="EFK56335">
        <property type="protein sequence ID" value="EFK56335"/>
        <property type="gene ID" value="HMPREF0766_13538"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1634309_0_0_10"/>
    <dbReference type="OrthoDB" id="1616608at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="167" mass="19697" checksum="35F1FB94C4743715" modified="2010-10-05" version="1">MIKQFEKYKGIHPGIVIDRELKKRSIKQRPFALSLEEHPQTFNAITKGKRGISTALALKIERELGLEEGTLVILQAYYDIQKIKEKEIKRTPDLHILSKALFWDTVIQHIDWKRQYRAVIQRVFERGNENDKNEIIRFYGAEKVKQALEDSNIRSPYTIYRPNKTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRN8</accession>
    <name>D7VRN8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter, major facilitator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_13642</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994896.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13642"/>
    <dbReference type="EnsemblBacteria" id="EFK56439">
        <property type="protein sequence ID" value="EFK56439"/>
        <property type="gene ID" value="HMPREF0766_13642"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_47_1_10"/>
    <dbReference type="OrthoDB" id="1452500at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="12"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="403" mass="44237" checksum="406F4BDCB98055FD" modified="2010-10-05" version="1">MKLYNPKYEGVCTLSIFLMIPLSGLVTDVYLPSFPEMQKMLHTHSAGIQLTLTYFLISYGISLLIAGSIVDSFGRYRIVLVALTAFLLSNLAIATIHNLHFIYLMRVLQGISAAFIVVGKRAFLVDIYSGRKLQHYTSMLTIIWAMAPITAPFIGGYLQQAFGWTANFYLLAGYSLICLLLELFFSGEALQVRKPFDTLNIRQSYQHVLGAPDFSIGLLVLGFSYGMVMVFGMAAPFIVEQRFHFSAVTTGYCALLSGLGLMTGGILGKTLHNKPFFSKLVSAVAIQLALSVIMYASSGYNPGIYVLMAFVLCLHVMSGFIYNIYFTYCLTRFPAHAGVASGLTSGGCYLVTSLASMILIKTIKINGQEGLAVSYFIFALLIVLSLIVFMKSVKPSEIPTVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRQ9</accession>
    <name>D7VRQ9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13663"/>
    <dbReference type="EnsemblBacteria" id="EFK56460">
        <property type="protein sequence ID" value="EFK56460"/>
        <property type="gene ID" value="HMPREF0766_13663"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZEYD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2332216_0_0_10"/>
    <dbReference type="OrthoDB" id="2178673at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="118" mass="14135" checksum="CBFDEF90017F60A4" modified="2010-10-05" version="1">MVFYIKYLSKNRYQSIKQFLMSNLSSSTPVKVQQMLESYYAEQQLQHSKKRQYILENILLHRDWIDAVDLWISLQRHVSISCIYQTLKLLVKAGIVEQRTGEDRKTHYRPLLQMSRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRU3</accession>
    <name>D7VRU3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">ychF</name>
        <name evidence="7" type="ORF">HMPREF0766_13697</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995045.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13697"/>
    <dbReference type="EnsemblBacteria" id="EFK56494">
        <property type="protein sequence ID" value="EFK56494"/>
        <property type="gene ID" value="HMPREF0766_13697"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018395_0_1_10"/>
    <dbReference type="OrthoDB" id="603226at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="3"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="6">
        <location>
            <begin position="281"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="366" mass="40239" checksum="72E8CD0E890B97FF" modified="2010-10-05" version="1">MALQCGIVGLPNVGKSTLFNCLSNAKAQAANFPFCTIEPNVGVITVPDERLNKLADLVKPQRLVPNTIEIVDIAGLVKGASKGEGLGNQFLGNIRTTNAIIHVLRCFDDGNVIHVDGSVDPIRDKEIIDTELQLKDLDTVVKRIQKVEKMAKTGGDKDAKRTFDILSVVKEHLESGKSVRTSPIEKEDFEFIQDLALLTAKPVLYVCNVDEASVNTGNSYVDKVKEAVKDENAEVLIISAQIESEIAQLESFEERQMFLDDLGLTESGVHKLIRAAYSLLDLATYFTAGVQEVRAWTIEKGYTAPQAAGVIHTDFEKGFIRAEVIKYADFIQYGSESAVKEAGKLSVEGKTYIVEDGDIMHFRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRX7</accession>
    <name>D7VRX7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995131.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56528">
        <property type="protein sequence ID" value="EFK56528"/>
        <property type="gene ID" value="HMPREF0766_13731"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50341NK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1852028_0_0_10"/>
    <dbReference type="OrthoDB" id="1897243at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107861" evidence="1">
        <location>
            <begin position="29"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="146" mass="15932" checksum="3087B21446B23761" modified="2010-10-05" version="1">MKNTFSMKHRLFIIAVLISFVCMSEVQAQSKTVATNYFSIAGKEICNFAGKYSSEGEEIGVIAFDMSQTGTKVKGKARYMTFGKKAKTLTLSVDGNIKSDIAYIQFKDQKGAVVAKGTLSIDGEDTLIFKQTTSSGLIPHEAVLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRY8</accession>
    <name>D7VRY8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995156.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13742"/>
    <dbReference type="EnsemblBacteria" id="EFK56539">
        <property type="protein sequence ID" value="EFK56539"/>
        <property type="gene ID" value="HMPREF0766_13742"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033FGP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1395524_0_0_10"/>
    <dbReference type="OrthoDB" id="1970553at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="195" mass="22118" checksum="426BF4886F5AC4FE" modified="2010-10-05" version="1">MKTILFAIPFVLLYSCNSKPENKKDLSAGDSISSAVSADTISKPVSDTKDLTWASIPVKQLPVTDSTNFDNYKPATKQNPELIKKINLKKAIEDATDFNINYSIPFSEKFETVVVTYHKGEMELCTSMLTVDKNYKIIDILPVAYDEVAESAFRKISTIEKGKITIEDWNYMQEEPTKETHIYTLQENGKFKEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS18</accession>
    <name>D7VS18_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sigma-70 region 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13772"/>
    <dbReference type="EnsemblBacteria" id="EFK56569">
        <property type="protein sequence ID" value="EFK56569"/>
        <property type="gene ID" value="HMPREF0766_13772"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4941">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035311_1_2_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="421" mass="48324" checksum="464CB0C0D7D627F7" modified="2010-10-05" version="1">MSGEKAHKDLLPHLFRQEYAKMTAVLCRHFGLHAIEIAEDIANDTFLKASEYWAINGIPENPVAWLYTVAKNKTKDYVKRTAIFETQIKQEIKPEHIDKEKEFEYNDQLIADSQLAMIFAVCNPANSRESQICLALQILCGFSIEEIADAFLKNTETIKKRLLRARTKLRNTSFQIKSISEGQIKSRLEVVLKTLYLLFNEGYFSKANKQQIRINLCSEAIRLTLFLTENPITNTSETSALMALMCFQSSRLQARMDINGETILFDGQDRTLWDQSLIQRGNYYLVNATTQSAKSPTKYHLEAGIAYWYTTSTDHSKWINILQLFDQLIIIEDSPITALNRVFAFANVHGKEKAILEAEKLNLIKNTSYQALMGYLYAHTDIDRSLAHYEQAIRLSRSSTEKHTLKKEIERLKFAKINAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS42</accession>
    <name>D7VS42_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995288.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13796"/>
    <dbReference type="EnsemblBacteria" id="EFK56593">
        <property type="protein sequence ID" value="EFK56593"/>
        <property type="gene ID" value="HMPREF0766_13796"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049717_2_0_10"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="310" mass="35398" checksum="A033A2CA42E0219A" modified="2010-10-05" version="1">MQTILGANGQIAKELAKELHRAYTTDIRLVSRSPKKVNDTDTLFTADLLDKVKADEAVAGSTIVYFTLGLPMDTRLWENQFPLLMRNVIEACQKHKTKLVFFDNTYMYPQNGAVLTEESVFEPVGRKGMVRKKMADMLLSEIEAGQIEAVICRAPEFYGPGKTQSITNTFIFDRIKQNRKLLVLLKDDTLRSLIWTPDASKATALIGNTPDAYGQTWHLPVDDNRLTYKAFIELVSDVYAKPLSYSVVPNIILKLGAVFNRKTREIQELLPRYAYDNIFDSDKFKKRFPDFSVTSFREGITQIKKEHQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS46</accession>
    <name>D7VS46_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13800"/>
    <dbReference type="EnsemblBacteria" id="EFK56597">
        <property type="protein sequence ID" value="EFK56597"/>
        <property type="gene ID" value="HMPREF0766_13800"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1915764_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="133" mass="15378" checksum="5974FD301DCFC647" modified="2010-10-05" version="1">MKNSKIKYIGIIMFLGLMVGCITSKKPAWQGRYTKKNVYDKNIEKDKIAVSINLFDYRDNSKIDISDVKDLPGKVIASSENSKLFLFHKDSVPESIWIEKLNKGAIKIRPKKEHKKNLIIYNLYLGHLPRNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS94</accession>
    <name>D7VS94_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995424.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56645">
        <property type="protein sequence ID" value="EFK56645"/>
        <property type="gene ID" value="HMPREF0766_13848"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1980155_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="126" mass="14224" checksum="935939151608D2C5" modified="2010-10-05" version="1">MNRIINGIIIVCFMALVSCSTYKFVEGSVLKSWTVKSGEVAVLKSSKSKIYRFRIINNSYEDNDLIVKNADGTFIRQIASHDTAEVKAALNDIRIENSGQKDAIFTLSVFLNRESFKMPEVKKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSE9</accession>
    <name>D7VSE9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TonB-dependent siderophore receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0766_13903</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995540.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13903"/>
    <dbReference type="EnsemblBacteria" id="EFK56700">
        <property type="protein sequence ID" value="EFK56700"/>
        <property type="gene ID" value="HMPREF0766_13903"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_9_4_10"/>
    <dbReference type="OrthoDB" id="169533at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107325" evidence="7">
        <location>
            <begin position="23"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="9">
        <location>
            <begin position="139"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="8">
        <location>
            <begin position="319"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK56700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="805" mass="89514" checksum="15562F5A491019A2" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSI0</accession>
    <name>D7VSI0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative alpha-1,2-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_13934</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995587.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13934"/>
    <dbReference type="EnsemblBacteria" id="EFK56731">
        <property type="protein sequence ID" value="EFK56731"/>
        <property type="gene ID" value="HMPREF0766_13934"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003690_0_1_10"/>
    <dbReference type="OrthoDB" id="100818at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="Alpha_mannosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107243" evidence="2">
        <location>
            <begin position="19"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92N" evidence="4">
        <location>
            <begin position="30"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92" evidence="3">
        <location>
            <begin position="264"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="763" mass="86522" checksum="E1FE0A4CC5044694" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSJ5</accession>
    <name>D7VSJ5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lacA2</name>
        <name evidence="6" type="ORF">HMPREF0766_13949</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995602.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13949"/>
    <dbReference type="EnsemblBacteria" id="EFK56746">
        <property type="protein sequence ID" value="EFK56746"/>
        <property type="gene ID" value="HMPREF0766_13949"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_3_0_10"/>
    <dbReference type="OrthoDB" id="1878940at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039369">
        <property type="entry name" value="LacA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43017">
        <property type="entry name" value="PTHR43017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mac" evidence="5">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK56746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="198" mass="22370" checksum="064C1AE8CB9EABE7" modified="2010-10-05" version="1">MKTAKELMLSSEPYRAMGKELFEDRQYAKEELYKYNSLAPSKIRERNQIIKKLFAKTGSRLFIEPPFRCDYGYNIEIGDNFYANYNCTILDGAKVSIGENVMFAPNVSLFTAGHPIHATPRNEGWEYAFPIIIGDNVWIGGNVVINPGVMIGENTVIGAGSVVTRDIPANVIAVGNPCRVLRPITDEDKQYYFRDKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSM7</accession>
    <name>D7VSM7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995653.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13981"/>
    <dbReference type="EnsemblBacteria" id="EFK56778">
        <property type="protein sequence ID" value="EFK56778"/>
        <property type="gene ID" value="HMPREF0766_13981"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3911">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114480_0_0_10"/>
    <dbReference type="OrthoDB" id="1392851at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_28" evidence="1">
        <location>
            <begin position="10"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="185" mass="21943" checksum="17C1A7948C5FAD58" modified="2010-10-05" version="1">MNTIERNNFYILTGGPGTGKTSLLETLADDVQIVAEVARTIIKEQIRSNGRALPWADQQAYAKLMFEYSLRDFKYFNNQNHNQITLFDRGLPDTLCYLEMLGENIPVQMDTAVRNYRYSPVVFILPAWKEIYEQDQERKQSWEEAEQTYYYMKQTYEKYGYRLIDVPKASLEERRIFILDQLHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSP8</accession>
    <name>D7VSP8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carb-bd_dom_fam9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995700.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14002"/>
    <dbReference type="EnsemblBacteria" id="EFK56799">
        <property type="protein sequence ID" value="EFK56799"/>
        <property type="gene ID" value="HMPREF0766_14002"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106157_0_0_10"/>
    <dbReference type="OrthoDB" id="922127at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010502">
        <property type="entry name" value="Carb-bd_dom_fam9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16011">
        <property type="entry name" value="CBM9_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carb-bd_dom_fam9" evidence="1">
        <location>
            <begin position="27"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="216" mass="24746" checksum="FD8C4A56852BAA9F" modified="2010-10-05" version="1">MKNLTVKYAEQKQNNNYSGLLEIFKGATVHAIAEATWKDEYPDQPEVHFQIVYTSEAIFIHYKVREDYIKAQYIRPNEAVWEDSCVEFFISFDQKVHYYNIEMNPLGTGLVGYGTADKDSRSRLTAEQIQQINTYTEVSSIGGQKLWNTILEIPFTLFTSAGTMVSAESLKGQSVHANFYKCGDGLPAPHFVSWNRIDFPTPNFHLPEFFGEISFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSX3</accession>
    <name>D7VSX3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995868.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14077"/>
    <dbReference type="EnsemblBacteria" id="EFK56874">
        <property type="protein sequence ID" value="EFK56874"/>
        <property type="gene ID" value="HMPREF0766_14077"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_4_3_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="122"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="193" mass="22486" checksum="5AD5B475D3F01BDB" modified="2010-10-05" version="1">MSVQHRPSVLVEYPLNTGVESDFDYIYLTYFAPLCYFASKFVDDQAVDIVNSLFAKLWTSEIVLNNANHAQSFLYLSARNACLDFIKTSGRAKERDAEFSYLYQLSEEDLQLEVVYVEYMAEIYREINNLPVQCSKIIKLSYLDGVKNEKIAEQLNISVQTVKNQKSKGLKILRKLFINHPDKYLFFLFLFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSZ3</accession>
    <name>D7VSZ3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56894">
        <property type="protein sequence ID" value="EFK56894"/>
        <property type="gene ID" value="HMPREF0766_14097"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_735490_0_0_10"/>
    <dbReference type="OrthoDB" id="1812882at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="377" mass="45512" checksum="030C0978BEBBB97B" modified="2010-10-05" version="1">MRHLAYGINYTILLTDEEIRNPFIVLDDVFRSNSSCFQMQERLWDLVTVAMRPNYWMHYDSPLEICNLYTSIVRLVEAGWLISQIRPAKEQKATLSDKFMTREPHQKRTFIKPIEQHTVLNAYKVMLQSYKEDKFFSLRIDLFEFLFEGLHPTCVDYSPSLSEYLVDRYHCLSRLIDALYMIHDQEKRRESSEEDLLILEKYQKDDTSGIRQTDIYRHQLADMFTYSKKEDLRQALSSSYEVLYHKDFWKYHHDPANVLYYFHDFEFIMDRSYVFLKESLLKNTAPDQEWGIPDNILQEMESLHLKENKRPLKYLKEMFDIRTLKEWKSELANWQEAVLSNKKIPYDQKTTYKEVRQFLTGLIEFIELIPYEPEVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT23</accession>
    <name>D7VT23_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">narL</name>
        <name evidence="3" type="ORF">HMPREF0766_14127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995984.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14127"/>
    <dbReference type="EnsemblBacteria" id="EFK56924">
        <property type="protein sequence ID" value="EFK56924"/>
        <property type="gene ID" value="HMPREF0766_14127"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1155804_0_0_10"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="100"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="240" mass="27327" checksum="712772CDFAC2F3BE" modified="2010-10-05" version="1">MDGKDIFYPEFDHPATQLSAFSLCIDVFIISLKNGEIVHFKPNEIAHFKDWLDRFKVRDIEVDKGIPYVTRTPNLSKAPNGFFNLIKLSKKKMSKEQIIKVGMIDDHDMLRKGICDFLMGFGFEILFEAENGKMAMKKMEEIEVVPDVMVVDINMPVMNGFETAKALNEKYPQTKVLAFSINDDVQDVVKMLQRGVKGYILKGADPEELKKAITVINDGGHYFSAGVAEIAKEYYKQFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT61</accession>
    <name>D7VT61_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_14165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002978445.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14165"/>
    <dbReference type="EnsemblBacteria" id="EFK56962">
        <property type="protein sequence ID" value="EFK56962"/>
        <property type="gene ID" value="HMPREF0766_14165"/>
    </dbReference>
    <dbReference type="GeneID" id="66690336"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_8_3_10"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="368" mass="41539" checksum="37A6DA0D81F43288" modified="2010-10-05" version="1">MKQFLSFVRKEFYHVFRDSKTLLMLFGLPIVQIVLFGFALTNEIKNSKIVICDYAKDEATQQIINKIEASRNFEIQKALMSHKQIEEAFKEGNTKLAIIFPTNFNKDLLHLNQAQVQIIADASDPNTANTLTNYATNIIMDYQQELMKNNAMPFRIVPELRMLYNPELKGATNFVPGVMALVLMLICVMMTSVSIVREKETGTMEVLLVSPFNPFLVIISKAIPYLFLSLINLTIILVLSITLLDMPINGSVLLLFATSTLLIICALSLGLLISNVTQSQQAAMLISMMGMLVPTMLFTGFMFPIENMPVPLQVICNLIPSKWYYTIVKSIMIKGLGFSAIWKEILVLFGMTCFLLVVSFKKFKTRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT85</accession>
    <name>D7VT85_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-2-macroglobulin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996122.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14189"/>
    <dbReference type="EnsemblBacteria" id="EFK56986">
        <property type="protein sequence ID" value="EFK56986"/>
        <property type="gene ID" value="HMPREF0766_14189"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001849_0_0_10"/>
    <dbReference type="OrthoDB" id="231654at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041246">
        <property type="entry name" value="Bact_MG10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17973">
        <property type="entry name" value="bMG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A2M" evidence="2">
        <location>
            <begin position="1226"/>
            <end position="1316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1953" mass="223882" checksum="5B542071F2E437F9" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTK8</accession>
    <name>D7VTK8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996418.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14312"/>
    <dbReference type="EnsemblBacteria" id="EFK57109">
        <property type="protein sequence ID" value="EFK57109"/>
        <property type="gene ID" value="HMPREF0766_14312"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116201_0_0_10"/>
    <dbReference type="OrthoDB" id="1278667at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016786">
        <property type="entry name" value="YdeI_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021308">
        <property type="entry name" value="UCP021308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="18"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="193" mass="22578" checksum="BA20FD7B4DF53C83" modified="2010-10-05" version="1">MNTAAGHFFERNQKWSTEFHLLREIITENTDLLEDFKWMHPCYTLNGKNIVLIHGFKEYCALLFHKGALMTDPEHILIRQTENVQSARQIRFTNSEQITALRSVITAYIREAVEIEKSGKKVEMKKTADYPVPDEFQRAMEEDTALKKAFHTLTPGRQKGYLFYFNQAKQAATRESRIEKYYQHILDGKGLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTK9</accession>
    <name>D7VTK9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_14313</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996419.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14313"/>
    <dbReference type="EnsemblBacteria" id="EFK57110">
        <property type="protein sequence ID" value="EFK57110"/>
        <property type="gene ID" value="HMPREF0766_14313"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031BQE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142057_0_1_10"/>
    <dbReference type="OrthoDB" id="1753156at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016944">
        <property type="entry name" value="UCP030066"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030066">
        <property type="entry name" value="UCP030066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK57110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="146" mass="16009" checksum="E8658CFC202155EF" modified="2010-10-05" version="1">MTDCKVYVINLYNTIMTGETNFARSLRLRKVLYWIGTGLLAAGMLSGGLAQLSGAKKSAEGIAHLGYPVYLMYILGSWKIAGVIAILIPGFKLLKEWAYAGFFFAMSGATLSHIAAGDAFSQALASFIFILLILISWYFRPAERKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTN9</accession>
    <name>D7VTN9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001681.1">
        <property type="nucleotide sequence ID" value="NZ_GL379777.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14359"/>
    <dbReference type="EnsemblBacteria" id="EFK55798">
        <property type="protein sequence ID" value="EFK55798"/>
        <property type="gene ID" value="HMPREF0766_14359"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZB91">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103294_0_0_10"/>
    <dbReference type="OrthoDB" id="1702213at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107926" evidence="1">
        <location>
            <begin position="21"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="207" mass="23169" checksum="3DEFEE10AC30122A" modified="2010-10-05" version="1">MKTTLLLLALLITNSMFAQSAYEKGMANGMQLWQSGKNTEAAAQFERIAQVEKDNWIPAYYQSFITILSAFNARDADSKMSLIKTAKTILDAYPAQHNNPEWLVLKAMNYTAELTTDPMTKAQELSPLIIATYEKAKAIAPENPRVILSLAQFQMQSKKYFHQDTSAECESIKKALHLFDTQKSETAFAPSWGKEQAEQIVSSCASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTS1</accession>
    <name>D7VTS1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002198.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14391"/>
    <dbReference type="EnsemblBacteria" id="EFK55700">
        <property type="protein sequence ID" value="EFK55700"/>
        <property type="gene ID" value="HMPREF0766_14391"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503495S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157289_0_0_10"/>
    <dbReference type="OrthoDB" id="1286390at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025563">
        <property type="entry name" value="DUF4286"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14114">
        <property type="entry name" value="DUF4286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="94" mass="10983" checksum="123DE31E0781C1D6" modified="2010-10-05" version="1">MYLYNISIITEDSVHAEIMDWVKTEILSQNEYPAKFLALLNSPHEGQTHCIQLVVEKEQDIETFNAKYLVPFQEFISTSHHGKAFIFDSIMKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTU0</accession>
    <name>D7VTU0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron transfer flavoprotein FAD-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">etfA</name>
        <name evidence="3" type="ORF">HMPREF0766_14410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002235.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14410"/>
    <dbReference type="EnsemblBacteria" id="EFK55719">
        <property type="protein sequence ID" value="EFK55719"/>
        <property type="gene ID" value="HMPREF0766_14410"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034178_0_1_10"/>
    <dbReference type="OrthoDB" id="1400253at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="2">
        <location>
            <begin position="3"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK55719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="324" mass="33706" checksum="910375403B7BB4F8" modified="2010-10-05" version="1">MSVLVYIENIEGQFKKSAFEAISYAKAIADQTGTTVTAISIGDVSNSELEKPGQFGASKVLNVQNGDLKNFVNQAYASVIAEAAHKEGSKIVVLSNSFSGKGLAPRIATKLHAGLADGVIELPQISGDSLSVKKTAFSNKAFATVELSSAVKVISVNPNAYEAKAVGGSAAIEAFTPQLQATDLSTIVKEIVRATDKVSLPEAEIVVSAGRGLKGPENWAIIEELADVLGAATACSKPVSDAGWRPHSEHVGQTGIVVSPNLYIAIGISGAIQHLAGVSSSKTIVVINKDPEAPFFKVADYGIVGDAFDIVPKLTAALKAYKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VG97</accession>
    <name>D7VG97_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
            <ecNumber evidence="2">3.5.2.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pyrC</name>
        <name evidence="2" type="ORF">HMPREF0766_10016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001850.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10016"/>
    <dbReference type="EnsemblBacteria" id="EFK60072">
        <property type="protein sequence ID" value="EFK60072"/>
        <property type="gene ID" value="HMPREF0766_10016"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_1_0_10"/>
    <dbReference type="OrthoDB" id="1319925at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="55"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="421" mass="45329" checksum="88A7B3CBC095D48B" modified="2010-10-05" version="1">MSTLLITSATVILPGNEHHRKEVDVLIENGKIVKIGKRIKASDSAANVVDAKGAFLAPGFFDLNVNFGEPGLETKEDIQTGTAAAAAGGFTGVAVQPNTEPAIQSRSEVALVINAAKGNLVDVYPVGAISKKREGKELAELYDMQQTGAVAFSDGNRSVQQAGLMSRALLYSKGFNGLIISHPEDESMAGGNQMNEGVVSTYLGMKGIPNLAESLMLSRDLYLAEYNESPIHFSTISTAEAVDLIKKAKAKGQQVTCDVAAHHLVLSDKEVEGFDSNYKVNPPLRTKQDIKALLKGLKDGIINAVVSQHTPQEVEYKKVEFHIAKNGIIGLQTVLPLLVQAGLDEEIIVEKLSIGPRKVLGLEVPSLQEGEAANIVLFDTKQKWTFDTAQNKSKSENSPFFGQEMTGKVLLVFNNGKIFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGA8</accession>
    <name>D7VGA8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10027"/>
    <dbReference type="EnsemblBacteria" id="EFK60083">
        <property type="protein sequence ID" value="EFK60083"/>
        <property type="gene ID" value="HMPREF0766_10027"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078522_2_0_10"/>
    <dbReference type="OrthoDB" id="1436862at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018750">
        <property type="entry name" value="DUF2306_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10067">
        <property type="entry name" value="DUF2306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="213" mass="25284" checksum="2BA8B422EE8D8E4F" modified="2010-10-05" version="1">METSYKNLTIQLFWLLIFSYSCYLMAEITWRYRFFELDVAFLQIKQTEIQHVSWYKYIFYTHVCTAILALPAGFTQFNSRLLLCYPRIHRRVGYLYVGIILFLAAPSGILIGLHANGGITAQVAFVLLGLLWFYFTLMAVLTIRKGNVRSHQKFMYRSFALTCSALTLRYWKVVIVYFFQPNPMDVYQIIAWLGWVPNLLIIEWFIYRKFNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGD1</accession>
    <name>D7VGD1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0766_10050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001943.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10050"/>
    <dbReference type="EnsemblBacteria" id="EFK60106">
        <property type="protein sequence ID" value="EFK60106"/>
        <property type="gene ID" value="HMPREF0766_10050"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_10"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="172"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="233"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK60106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="451" mass="51302" checksum="46652767CAABAF19" modified="2010-10-05" version="1">MRSYNKTLYFSIGILIVYTVLFVTFIFYSISNFAFSDFYKRLELRRKLAAERLLKTDHSGDQQHLQTEYVENLFNQKEFMAEIDKQGNFRSIVAFPADLSGQISKNGPSNFKDGKIFYSTNIYQKDGRHYLIGVSAENYFYTHHLAYLRNLLFISLLFACLLIIVISMIVKRSFLKPIHKIIKEVEIIGSENLYLRLNESKDKSVLNKLAATFNSMLNRIETSFETQKNFISNASHELNTPLTSIIVTADLALSKQRTDDEYRTALSRIMDAAGHLEKKTHALLLLARTGYEGNKINFKPTRVDQAVMDAELMVKQINNKFRIKTDFSLLPEDSMRLKVNGVLPLLHLAFSNIISNACKYSADQTAYIALGASKDKVVIVIKDNGIGIPEKELKHIYDPYFRASNTLNYSGYGIGLPLARNIIHMHNGQLRVSSVEGQGTTVTIELPSLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGV4</accession>
    <name>D7VGV4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996913.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10223"/>
    <dbReference type="EnsemblBacteria" id="EFK59306">
        <property type="protein sequence ID" value="EFK59306"/>
        <property type="gene ID" value="HMPREF0766_10223"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045945_5_1_10"/>
    <dbReference type="OrthoDB" id="1661714at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="111" mass="13272" checksum="4C4ED93FCDDEF2A0" modified="2010-10-05" version="1">MPYKEREINKLYYTMGEVTEMFNVNASQIRFYEREFTVLQPKKNKKGNRLFTQEDIANLKIIFNLVKEKGYTLQGARDYLRTNKNEARENQRVIDSLEKLKGFLLEVRDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGY8</accession>
    <name>D7VGY8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997011.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10257"/>
    <dbReference type="EnsemblBacteria" id="EFK59340">
        <property type="protein sequence ID" value="EFK59340"/>
        <property type="gene ID" value="HMPREF0766_10257"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042661_1_0_10"/>
    <dbReference type="OrthoDB" id="1778971at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="411" mass="46698" checksum="DD2E3D2A39DF80F1" modified="2010-10-05" version="1">MGTHSHHHDYNFSERFAFGGKAKVFSIIAIVIGLVAIAYGLFAGDSHTTERTYANLLLMGYYFTCVCAAGAFFVALQSVTQSAWSAGLIRIPQAMGSVLPIAALVLFIIIAAGLNSHSLYHHWAGHGLTDPNSPNYDALIAGKSTFLNVPLFLVRQILFMGSYSIFAFILTKLSYKEDLEGSLNSYKKTFKLSAIFLVVFGFTTPIWAFDTIMSLEAHWFSTMFGWYNFAAMWVSGLATIAIILILVKKAGYLAWVNENHLHDLGKLIFGFSIFWTYVWFAQFMLIWYSNIPEETVYFYKRWEPEYKPWFWLNILINFVSPVLLLMDRDAKRKQNMMLFVCIVLLLGHWLDYYIMIMPGTVDNHPGFGFIEVGTAIGFVGLFTFLVMSKLSKHALVPKHHPFLEESLNHQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGZ5</accession>
    <name>D7VGZ5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">msrB</name>
        <name evidence="5" type="ORF">HMPREF0766_10264</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997032.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10264"/>
    <dbReference type="EnsemblBacteria" id="EFK59347">
        <property type="protein sequence ID" value="EFK59347"/>
        <property type="gene ID" value="HMPREF0766_10264"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_8_1_10"/>
    <dbReference type="OrthoDB" id="1650261at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PTHR46081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MsrB" evidence="4">
        <location>
            <begin position="45"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="165" mass="18688" checksum="670F97AD268C0DDE" modified="2010-10-05" version="1">MLRKLFISLSVILSLWIIGTTFATGSFYSGKSTRDTLKNTLKMDDNSKYNELTPEEEYVILRKGTEYPFTGTLLDNKKKGTYICKRCNAPLYRSEDKFESHCGWPSFDDEIKGAVKHVPDADGRRTEIVCNACGAHLGHVFTGEQFTAKNTRHCVNSISMKFVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH61</accession>
    <name>D7VH61_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PhoH family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">phoH</name>
        <name evidence="4" type="ORF">HMPREF0766_10330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997182.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10330"/>
    <dbReference type="EnsemblBacteria" id="EFK59413">
        <property type="protein sequence ID" value="EFK59413"/>
        <property type="gene ID" value="HMPREF0766_10330"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051654_0_0_10"/>
    <dbReference type="OrthoDB" id="445854at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="3">
        <location>
            <begin position="119"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="324" mass="36248" checksum="778CAFAA986351AB" modified="2010-10-05" version="1">MNELLITLEEVNLVTLWGTQNENFEYIKKQFPKIRMVARGNELKVLGEEQEQQHFKGVFDQILSHIERFHSLSVLDLEEIIGVKHPVAEKKADGSEKKQEGAPAFSGEPIVYGPNGIIVRARTLNQRRMVDSISKNDILFAIGPAGTGKTYTAVALAVRALRNKEIKRIILTRPAVEAGENLGFLPGDLKEKVDPYLRPLYDALDDMIPAEKLKGYLENRTIEVAPLAFMRGRTLDNCFVILDEAQNATDMQLKMFLTRMGPTAKFIVTGDMTQIDLPKKNQSGLSTAVKLLEGIEGIDMIYLSGGDVVRHKLVKRILEAYGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHB5</accession>
    <name>D7VHB5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cytR</name>
        <name evidence="5" type="ORF">HMPREF0766_10384</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997298.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10384"/>
    <dbReference type="EnsemblBacteria" id="EFK59467">
        <property type="protein sequence ID" value="EFK59467"/>
        <property type="gene ID" value="HMPREF0766_10384"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_0_10"/>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="337" mass="37632" checksum="F1C9D28C5A98264A" modified="2010-10-05" version="1">MKKNIGIKEIADILNISVSTVSRALRDTYDVNPETRNRVLELAKELNFKPNKNAAALASGSTKNIGIVIPFITNYYFSTVISGIQEQAYESGYNVILYVTNDNAERERDLLENLAITSLDGLLISISSDSLLEDHFERLRNDGVPIVFFDRAPMNSTASKVLQDDFQGAYEATNYLIKHGYSRIAHIAGPKELKFTQQRLNGYLKALEQHRLPVRSDYIIHSGFSQNNGSEDTEKLLGLTQRPDAIFAVNDRKAVGAILTLKQHHIQVGAEVGVIGFTNDPIASVVEPNLTTIEEPAFEIGKRSCELLIKHIKNRNYESKDVILPGRLIVRDSVSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHC0</accession>
    <name>D7VHC0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl xylan esterase (AXE1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10389"/>
    <dbReference type="EnsemblBacteria" id="EFK59472">
        <property type="protein sequence ID" value="EFK59472"/>
        <property type="gene ID" value="HMPREF0766_10389"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3458">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_398867_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008391">
        <property type="entry name" value="AXE1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05448">
        <property type="entry name" value="AXE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107110" evidence="1">
        <location>
            <begin position="20"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="AXE1" evidence="2">
        <location>
            <begin position="90"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="665" mass="74782" checksum="53F3C8F00E3C416C" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHQ7</accession>
    <name>D7VHQ7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997639.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10526"/>
    <dbReference type="EnsemblBacteria" id="EFK59609">
        <property type="protein sequence ID" value="EFK59609"/>
        <property type="gene ID" value="HMPREF0766_10526"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061789_2_0_10"/>
    <dbReference type="OrthoDB" id="1431378at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="51"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="274" mass="31527" checksum="E9FC4B0C188B8369" modified="2010-10-05" version="1">MRKTNLISSSIERFYNKASEEDRLSKGMGIFEFERIKSLMELHLKPQSIILDIGGGTGKYSEWLSKLQHQVYLVEPIDKHLHIAKERSSKLKNKFQVIKGEARKLEFPNNFADVVILHGPLYHLQKEEDRLLVIKEAKRVVKKGGIILGFGINFTASTLAGLLNGLIYKPSFLEMCKSELLTGIHNPPDDFPWLLAEAFYHKPSEFKNEFLKCNLKIEKIYAVEGIIWLDSNFFANMLDEGRKKVLKELLSTTENEEFLLPFSPHMMIVTTKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHT4</accession>
    <name>D7VHT4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ribH</name>
        <name evidence="8" type="ORF">HMPREF0766_10553</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997708.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10553"/>
    <dbReference type="EnsemblBacteria" id="EFK59636">
        <property type="protein sequence ID" value="EFK59636"/>
        <property type="gene ID" value="HMPREF0766_10553"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0054">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089358_1_1_10"/>
    <dbReference type="OrthoDB" id="1680292at2"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="65"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="89"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="94"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="163" mass="17325" checksum="01B8D089DC84B7B7" modified="2010-10-05" version="1">MASNLKNLSDFSHIQVGDAKQFKFGIVVSQWNAQVTGALLNGAVEGLLKHNALESNIEIVEVPGSYELISGADILLRNKDFDAVICLGCVIQGETRHFDFICDAVANGVANAALKYGKPVIFGVLTTDNLQQALDRAGGIHGNKGEEAAITAIQMAHISAKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHW5</accession>
    <name>D7VHW5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK59667">
        <property type="protein sequence ID" value="EFK59667"/>
        <property type="gene ID" value="HMPREF0766_10584"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3122808_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="50" mass="5524" checksum="062C2B364543B617" modified="2010-10-05" version="1">MNSPLASAAGAIKARQTFNRALWKKSVFLRVVCSVNIDKYAPQKQEDGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHZ0</accession>
    <name>D7VHZ0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase family M1</fullName>
            <ecNumber evidence="3">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997849.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10609"/>
    <dbReference type="EnsemblBacteria" id="EFK59692">
        <property type="protein sequence ID" value="EFK59692"/>
        <property type="gene ID" value="HMPREF0766_10609"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015077_1_0_10"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106971" evidence="1">
        <location>
            <begin position="20"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="2">
        <location>
            <begin position="348"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="620" mass="71106" checksum="89437EA1576DCBEE" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI09</accession>
    <name>D7VI09_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997888.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10628"/>
    <dbReference type="EnsemblBacteria" id="EFK59711">
        <property type="protein sequence ID" value="EFK59711"/>
        <property type="gene ID" value="HMPREF0766_10628"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_4_10"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="228"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="439" mass="50125" checksum="E81DE6C4424C40DD" modified="2010-10-05" version="1">MTRFKWWIACSYVLLIGLGAICCFALISEWYLLASLAGLLAIVTFTAGLKAQFEIYDVFMDFVQSTRQRDFTRYYVTKKTSSTKRRIHETFNEINAAFKEITVSKELQYQYLNQIVNMLDTAIFTYYPDKDKVIWMNEAFRVMFDIPYVGKFTSLEKRNKELFKIINNLQTGQQHIEAVSSAKGKVKLLMQLSELVTQEGRCQIVVFQNVNEAIDETETKAWHKLLRVLTHEIMNSIAPISSLAETMSQHLDRLNPAEELEDVRIGVDTIRNRSEGLLKFAKSYRTINKVDKPQLQEIMVSDLFENIYQLLEPTFVQKNIEFDVILKPTRIQLFADANLVEQVLINLVLNAMEAVKDVEKPYITMSAIEKGGNVQIHVSDNGIGIDTELMENIFTPFFTTRKTGSGVGLTLSKQIMLIHGGNILVESAVGKGSTFTLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI49</accession>
    <name>D7VI49_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997968.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10668"/>
    <dbReference type="EnsemblBacteria" id="EFK59751">
        <property type="protein sequence ID" value="EFK59751"/>
        <property type="gene ID" value="HMPREF0766_10668"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032TSW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129762_0_0_10"/>
    <dbReference type="OrthoDB" id="1517289at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107160" evidence="1">
        <location>
            <begin position="22"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="176" mass="19677" checksum="13F01173303D2C64" modified="2010-10-05" version="1">MKWLVLLLIFISFANAETAFAQVARPVQLNIILHEVQHLSVNPEQSTTNLEYKTVKDYREGVSKTQNNHLTVLSTTPYIIKVQVMENEQQAGTSASVSSPSLELFAQPTNSTFPVHTELQQLSTKDASLISSDHPSTGTYYDVIYKSTGQQSAIDFIKNNEKTTYSNTILYSIESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI53</accession>
    <name>D7VI53_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10672"/>
    <dbReference type="EnsemblBacteria" id="EFK59755">
        <property type="protein sequence ID" value="EFK59755"/>
        <property type="gene ID" value="HMPREF0766_10672"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9EE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_318514_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="921" mass="104340" checksum="526A028E756E29C2" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI60</accession>
    <name>D7VI60_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_10679</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997988.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10679"/>
    <dbReference type="EnsemblBacteria" id="EFK59762">
        <property type="protein sequence ID" value="EFK59762"/>
        <property type="gene ID" value="HMPREF0766_10679"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_3_10"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK59762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="227" mass="26523" checksum="18A7689D4454F2EA" modified="2010-10-05" version="1">MKGKILIIEDDIDLGLVTQQYLQTSGFETLLATSSREAEELCQKQLFDLLIVDVQLPDDTGFDLVRQLLETQPEQRFIFLTARNTKESKIYGLKLGGDDYITKPFDIEELSWRIHNIINRQQVRRSADLAIGDIRIIQDQMMLIFENNYEVKLTEREFAVWKYFALNPNRVLKREDILLAVWGENDYFLGRSLDVFVSRIRKLLSHSANVQLETVYKVGFIFRIPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI62</accession>
    <name>D7VI62_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide biosynthesis protein</fullName>
            <ecNumber evidence="4">3.6.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ppx2</name>
        <name evidence="4" type="ORF">HMPREF0766_10681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.11" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997992.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10681"/>
    <dbReference type="EnsemblBacteria" id="EFK59764">
        <property type="protein sequence ID" value="EFK59764"/>
        <property type="gene ID" value="HMPREF0766_10681"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013560_5_2_10"/>
    <dbReference type="OrthoDB" id="662797at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_2" evidence="3">
        <location>
            <begin position="300"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="647" mass="74207" checksum="CFF9E2FD6DCFC447" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIB4</accession>
    <name>D7VIB4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LUD_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10733"/>
    <dbReference type="EnsemblBacteria" id="EFK59816">
        <property type="protein sequence ID" value="EFK59816"/>
        <property type="gene ID" value="HMPREF0766_10733"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1556">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090664_3_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="126"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="234" mass="26326" checksum="7982BFDB759CABE4" modified="2010-10-05" version="1">MYCSFAYGTSFFIAVNTSQMNIKNTTAKEKMLKKIRQALLQKRENPHPDFEDSPLYKDEEESLDVTFAREFTAISGKFVYCDGEINLIENLIAFAEQQNVTRIYGWEDSVKQLLGQYGFPLMTDDQNFQQAQVGITACEALIARNGSIMISNANAGGRRLSIYPPVHIVIAKASQLVMDVKHALNGIKQKYGDHLPTMITTITGPSRTADIEKMLVLGAHGPKELYVFMLEDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIJ8</accession>
    <name>D7VIJ8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998259.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10817"/>
    <dbReference type="EnsemblBacteria" id="EFK59900">
        <property type="protein sequence ID" value="EFK59900"/>
        <property type="gene ID" value="HMPREF0766_10817"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2525847_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="84" mass="9804" checksum="28A30DBB9FC1A570" modified="2010-10-05" version="1">MIFREKNIKYLTEIIFSLFMFMVLPFINIPTTQSAKEITLPANKNSALYAPVDKELIVDTWLQHYNEKINRYDTVLFISSATIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIN9</accession>
    <name>D7VIN9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cdsA</name>
        <name evidence="2" type="ORF">HMPREF0766_10858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10858"/>
    <dbReference type="EnsemblBacteria" id="EFK59941">
        <property type="protein sequence ID" value="EFK59941"/>
        <property type="gene ID" value="HMPREF0766_10858"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058561_7_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="229" mass="25628" checksum="F2BF8798C4D65840" modified="2010-10-05" version="1">MLTDMETGIVNALILSGLFLSLFAVAELLYHCCKVRAEFTRKIVHAGTGLLALLFPLMLDNHWWVLVLCTSFTILLICSVHFRLLRSIHAIDRRSVGSLAYPVAVYGCYLSYTFLNNQLIYYYLPVLILAISDPLAALSGKRWPLGAYQIRGAHKTMVGSLFFFISAYLIMLVSCLIFRYPLQGQELLVLALLSIITALTEALSREGYDNVTIPFAVSAGFYIFDTLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIY9</accession>
    <name>D7VIY9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="5">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP cyclohydrolase I</fullName>
            <shortName evidence="5">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">folE</name>
        <name evidence="7" type="ORF">HMPREF0766_10958</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998551.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10958"/>
    <dbReference type="EnsemblBacteria" id="EFK60041">
        <property type="protein sequence ID" value="EFK60041"/>
        <property type="gene ID" value="HMPREF0766_10958"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049768_3_1_10"/>
    <dbReference type="OrthoDB" id="1632367at2"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="6">
        <location>
            <begin position="30"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK60041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="210" mass="23566" checksum="DC1465FD0A941716" modified="2010-10-05" version="1">MSNPSSLDHEEMDGYVKIDKYNPLHVDRIATHYTDILQALGEDPAREGLLKTPERVAKALKFLTHGYDLDPAAVLKGAMFEEDYSQMVVVKDIEVYSLCEHHMLPFFGKAHVAYIPNGHIVGLSKIPRVVDIFARRLQVQERLTNEIRDCIQETLGAQGVAVVMECKHMCMAMRGVQKQNSVTTTSAFTGAFQNDVTRSEFLRLITASLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ04</accession>
    <name>D7VJ04_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK60056">
        <property type="protein sequence ID" value="EFK60056"/>
        <property type="gene ID" value="HMPREF0766_10973"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3012015_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="56" mass="6850" checksum="18210E73AB48DB23" modified="2010-10-05" version="1">MPLRLYLEAYLRMYVHTGTRSKQVLPLKIIFQKKKTEKKESHFNKADRRKNQKETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ20</accession>
    <name>D7VJ20_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002113.1">
        <property type="nucleotide sequence ID" value="NZ_GL379779.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK59155">
        <property type="protein sequence ID" value="EFK59155"/>
        <property type="gene ID" value="HMPREF0766_10989"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142279_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107553" evidence="1">
        <location>
            <begin position="21"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="156" mass="18068" checksum="1BF798BEB829B687" modified="2010-10-05" version="1">MSKVILLIVFCISVLSCSFAQVKDDGFRFEHTEVVLAIKNIQMAIQANDRNTLKKLTTAAIKCPSCTPEKRNIYDPTRVKRKIFLNNLMQHRIIPLDETEENRISIKKDRNYEADLYVTLYSKSSLTNNSKPIYQLLLKRERNIFKLSGIKSLQTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJB7</accession>
    <name>D7VJB7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, group 1 family protein</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000545.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11086"/>
    <dbReference type="EnsemblBacteria" id="EFK58970">
        <property type="protein sequence ID" value="EFK58970"/>
        <property type="gene ID" value="HMPREF0766_11086"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_0_10"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="230"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="414" mass="47215" checksum="C88A311272A5D3F2" modified="2010-10-05" version="1">MKILFIQHLHFLNGSGGTEKICSFLANGFAKQGHQVTIATNQDIIGKPVFEIDRNIEVVNIYNPRVIQKELKSLYNYKGRNPIIWLISKIKKKSAKIYNNVLRKDLGGDAGIYKFNLSKRAELWNAYINELSPDVIVTMSISSLLEVTYNNKINIPIVNSVNGRPDYDYRNIFGRRSDFEMQLLEESFKNLSGIQVLFKSYCNFLPSTFNGGQYVIPNPVPQTTESDVVNHLKTKGKYRVIHIGRLDDDCKQQSIAIKIFNKIGSGFPEWELEFWGIGHDHNMLMQMISSYRLNNRVFLRGFTENPLEKIKEGDIFIFPSKYEGFGLALGEAMSAGLPCLGFQSCSGVNELIEHGVTGFLAKDESEMQKHLEELMQNRALRKEMGFQAHLAMKRYSPCHVLDAWKNLISDIVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJV3</accession>
    <name>D7VJV3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RHS repeat-associated core domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11272"/>
    <dbReference type="EnsemblBacteria" id="EFK58555">
        <property type="protein sequence ID" value="EFK58555"/>
        <property type="gene ID" value="HMPREF0766_11272"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004466_1_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045619">
        <property type="entry name" value="DUF6443"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20041">
        <property type="entry name" value="DUF6443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107586" evidence="1">
        <location>
            <begin position="21"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6443" evidence="2">
        <location>
            <begin position="109"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1143" mass="127869" checksum="A22218ABDFD1DE83" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKA5</accession>
    <name>D7VKA5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase family protein</fullName>
            <ecNumber evidence="1">5.4.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpm</name>
        <name evidence="1" type="ORF">HMPREF0766_11424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.-" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999073.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11424"/>
    <dbReference type="EnsemblBacteria" id="EFK58707">
        <property type="protein sequence ID" value="EFK58707"/>
        <property type="gene ID" value="HMPREF0766_11424"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_9_5_10"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="209" mass="24127" checksum="35E17F339C5E0FA1" modified="2010-10-05" version="1">MKKTFYFIRHGQTDLNLKGIVQGRGVNSPLNDNGRKQADAFYKAYKDVPFDKVYTSTLLRTHQTVAPFIEQGLDWEQLIGLDEISWGIYEGREQTPDIMSGFEKVIQAWRSGELDLNIEDGESPNQLVERQKEAIAYMLDQPEEKTVLVCLHGRALRILMCVLTDTDVCMMDDFPHTNTALYIVEFENGKFNVIDYYNTKHLEEIAEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKB6</accession>
    <name>D7VKB6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase (ATP)</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lig</name>
        <name evidence="7" type="ORF">HMPREF0766_11435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999102.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11435"/>
    <dbReference type="EnsemblBacteria" id="EFK58718">
        <property type="protein sequence ID" value="EFK58718"/>
        <property type="gene ID" value="HMPREF0766_11435"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005138_6_2_10"/>
    <dbReference type="OrthoDB" id="1073940at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026333">
        <property type="entry name" value="ATP_dep_DNA_lig_pp_1105_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04120">
        <property type="entry name" value="DNA_lig_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="6">
        <location>
            <begin position="303"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="530" mass="61048" checksum="6D2D652227427818" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKE8</accession>
    <name>D7VKE8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polysaccharide lyase family 8, super-sandwich domain protein</fullName>
            <ecNumber evidence="7">4.2.2.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cslA2</name>
        <name evidence="7" type="ORF">HMPREF0766_11467</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polysaccharide lyase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.5" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999194.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11467"/>
    <dbReference type="EnsemblBacteria" id="EFK58750">
        <property type="protein sequence ID" value="EFK58750"/>
        <property type="gene ID" value="HMPREF0766_11467"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004172_2_1_10"/>
    <dbReference type="OrthoDB" id="941406at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030341">
        <property type="term" value="F:chondroitin AC lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038970">
        <property type="entry name" value="Lyase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011071">
        <property type="entry name" value="Lyase_8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012970">
        <property type="entry name" value="Lyase_8_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004103">
        <property type="entry name" value="Lyase_8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003159">
        <property type="entry name" value="Lyase_8_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38481">
        <property type="entry name" value="PTHR38481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02278">
        <property type="entry name" value="Lyase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02884">
        <property type="entry name" value="Lyase_8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08124">
        <property type="entry name" value="Lyase_8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49863">
        <property type="entry name" value="SSF49863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107326" evidence="3">
        <location>
            <begin position="24"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Lyase_8_N" evidence="6">
        <location>
            <begin position="41"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Lyase_8" evidence="4">
        <location>
            <begin position="339"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Lyase_8_C" evidence="5">
        <location>
            <begin position="597"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="696" mass="79136" checksum="3240FDE3F6F8E729" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKG7</accession>
    <name>D7VKG7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FUSC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999245.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK58769">
        <property type="protein sequence ID" value="EFK58769"/>
        <property type="gene ID" value="HMPREF0766_11486"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1289">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013315_0_1_10"/>
    <dbReference type="OrthoDB" id="1338660at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032692">
        <property type="entry name" value="YccS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12805">
        <property type="entry name" value="FUSC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="453"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="FUSC-like" evidence="2">
        <location>
            <begin position="88"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="672" mass="75914" checksum="E0231F7B69F518D2" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKI1</accession>
    <name>D7VKI1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999286.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11500"/>
    <dbReference type="EnsemblBacteria" id="EFK58783">
        <property type="protein sequence ID" value="EFK58783"/>
        <property type="gene ID" value="HMPREF0766_11500"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027389_2_3_10"/>
    <dbReference type="OrthoDB" id="1485205at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="248" mass="27306" checksum="04113605891B03E3" modified="2010-10-05" version="1">MSQPLFKQLHQQSTPLLLGNVWDAHSAQLAEKAGFASLGSSSHAIANLLGYEDGENITFEELFFIVQRIVKAVKIPVSVDFEAGYADDPETVARYVKQLSDIGVAGINLEDGQVENGKRSLGSAQLLADKIKAIKSVTDIYINARTDTYVTKQEDALKQSIERALIYQEAGADGIFVPVIETKTDIQQFTTEVALPLNVFLTPNLPNFDELGELGVKRLSHGAKLYEWLMKQAEEALTAFKKQPVLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKU7</accession>
    <name>D7VKU7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999517.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11616"/>
    <dbReference type="EnsemblBacteria" id="EFK58899">
        <property type="protein sequence ID" value="EFK58899"/>
        <property type="gene ID" value="HMPREF0766_11616"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142165_2_0_10"/>
    <dbReference type="OrthoDB" id="1712403at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008620">
        <property type="entry name" value="FixH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05751">
        <property type="entry name" value="FixH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="140" mass="16096" checksum="4D53C395466E0030" modified="2010-10-05" version="1">MNWGKKIVVSLAVFMSGIIGAGIYMVSHNADTLEEEDYYEKGLNYDDTYNRKSNVIRDHAEPVIRAVNDTLYIDFPHPQNKGKLVFKRPSDSHLDISLPFATASTGYRLPIQSFQKGRWSLEIQWEGNAVPYIFEKHIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKV8</accession>
    <name>D7VKV8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Redoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11627"/>
    <dbReference type="EnsemblBacteria" id="EFK58231">
        <property type="protein sequence ID" value="EFK58231"/>
        <property type="gene ID" value="HMPREF0766_11627"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_1_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="290"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="435" mass="49095" checksum="FD6238B6EDEC29AA" modified="2010-10-05" version="1">MWVSLDDGKTEPQKLKPDATGMFEFSTFLERGTDGRVSIDNPVKGSIPLYLEPGDNLLIRTDFKDNTSFSGTGAENAGVLKELMDLYLANYNKLDATKIPLNVLYEQNEQMNKANLDFLDNNKSKVSKSFYDHQRTKFYYDALGMEVIMPYLLSQGLNKKFSETLPPGYMDLMKKVKFSEALLAHDTYNRFVRGTLPVFLRFRRLNQLGQLDSASTLPEAEKRKMEYEQVKEHLSGKIRSLALFGIVNNMLLSAKDVNQCKDYIKQFAADGGSKEQLAELQRVYDQALKLSAGAVPPPFTLNDINGKQVSLKDFAGKVIYIDFWASWCSPCRYEMKNGSPKLHAKLANNKDVIFLYISIDDSEDKWRQAIAEDKIEGIHLLSKGGVKSVVAKAFNISGIPRYVIIGRDGKIIDNDAPRPSQDITYDKIIDALKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKX0</accession>
    <name>D7VKX0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase, C-terminal domain protein</fullName>
            <ecNumber evidence="9">1.3.8.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gcdH2</name>
        <name evidence="9" type="ORF">HMPREF0766_11639</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.6" evidence="9"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999588.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11639"/>
    <dbReference type="EnsemblBacteria" id="EFK58243">
        <property type="protein sequence ID" value="EFK58243"/>
        <property type="gene ID" value="HMPREF0766_11639"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_8_0_10"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="14"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="130"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="239"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK58243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="386" mass="42665" checksum="CD57D438470DED82" modified="2010-10-05" version="1">MKEVDYFQIDELLSEEQLMIRNTVREFVNKEIRPVIDEAAQQHKDIPGLMQKLGAIGALGPYIPQEYGGAGLDQLSYGLIMQELEAGDSAVRSAASVQSSLVMFPIYTYGSEEQKRKFLPKLATGELIGSFGLTEPNHGSDPGAMETRLSKDGDGYILTGAKMWITNAPVCDLAVVWARDEEGKVKGIIVERGMNGFTTPETHNKWSLRASKTGELIFEDVRIPQANILPDVSSMKGPLSCLNSARYGISWGVIGAAVDCYQTALRYSLERQQFGKPVASYQLQQKKLAEFLTEITKAQLLSWRLGVLKNEGKATPQQISMAKRNNVNMALQIARESRQMLGAMGIVGEFPIMRHMMNLESVITYEGTHDIHLLITGQDITGISAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL38</accession>
    <name>D7VL38_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Emp24/gp25L/p24 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999749.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11707"/>
    <dbReference type="EnsemblBacteria" id="EFK58311">
        <property type="protein sequence ID" value="EFK58311"/>
        <property type="gene ID" value="HMPREF0766_11707"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1053392_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031712">
        <property type="entry name" value="DUF5077"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16871">
        <property type="entry name" value="DUF5077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107638" evidence="1">
        <location>
            <begin position="24"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5077" evidence="2">
        <location>
            <begin position="61"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="264" mass="29878" checksum="540AB7202DA1207D" modified="2010-10-05" version="1">MILKFFRISPLLLFIFLCETLNAQEKTFTIPANKAYAVPYTPDEKEVGVSVPVGYPEDKGSISNWTNKNRSIVWYLYQTAGTYYLDFDNTTAKGKNLTFNLKMSPCYAPLQISPSQTQIVFKGQGRQTRTSAGSILINQTGYYKYELSPQSEPSNAIVIHNLIFKSTTDNAHVNHTDYQSTPSVHINFSSAAATTKSYNWLYEEVNVPQGAARFIPSIWLSVSTEAISACRRIAKQKEECCFQYGTAKMQSMMQRLLNMIMYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL73</accession>
    <name>D7VL73_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen-III synthase</fullName>
            <ecNumber evidence="2">4.2.1.75</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hemD</name>
        <name evidence="2" type="ORF">HMPREF0766_11742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.75" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11742"/>
    <dbReference type="EnsemblBacteria" id="EFK58346">
        <property type="protein sequence ID" value="EFK58346"/>
        <property type="gene ID" value="HMPREF0766_11742"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076006_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="PTHR12390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEM4" evidence="1">
        <location>
            <begin position="59"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="259" mass="29850" checksum="9F06E5EF89083A2F" modified="2010-10-05" version="1">MNNMQTSDVERAKKVKSILVTIPKPDNDKSPYFNLAEKYNLKLDFRGFIHVEGVPAKDVRRDKINLSEHTAVIFTSKNAVDHFFRVCEEMRFEVSAEMKYFCITEAIALYLQKYIQYRKRKIFFGKQTAKDLEDVLKKHSKEKFLFPCSDVANEETQNWLQVNGYNFTPAVLFRTVISDLSDLKDVFYDIIVFFSPSSVQSLYENFPDFKQNNTRIAAFGATTQQALLDHGLILDIPAPTPAAPSMTMAVEQYIKLVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLC6</accession>
    <name>D7VLC6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase</fullName>
            <ecNumber evidence="2">1.7.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.-.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999999.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11795"/>
    <dbReference type="EnsemblBacteria" id="EFK58399">
        <property type="protein sequence ID" value="EFK58399"/>
        <property type="gene ID" value="HMPREF0766_11795"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055322_1_2_10"/>
    <dbReference type="OrthoDB" id="1818437at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="173" mass="19552" checksum="44344F778DE4A093" modified="2010-10-05" version="1">MNLIISGTNRVGSHSLKVASYYQQELSRKGEEWGLLSLGDLPENIIVSDLYNNRSEAFSVIQEQVSAAKKFIFIIPEYNGSYPGVLKVFIDACTFPVSFFNKKVALVGVSSGKYGNIRGVDHFTGVCNYLRMHVLPLKIHIPHIQSELNEDQQLFQSTTVKFVQEQIHEIIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLE2</accession>
    <name>D7VLE2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000042.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11812"/>
    <dbReference type="EnsemblBacteria" id="EFK58415">
        <property type="protein sequence ID" value="EFK58415"/>
        <property type="gene ID" value="HMPREF0766_11812"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033227_0_0_10"/>
    <dbReference type="OrthoDB" id="1439085at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033922">
        <property type="term" value="F:peptidoglycan beta-N-acetylmuramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008302">
        <property type="entry name" value="NamZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42915">
        <property type="entry name" value="PTHR42915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07075">
        <property type="entry name" value="DUF1343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016719">
        <property type="entry name" value="UCP016719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107281" evidence="1">
        <location>
            <begin position="27"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="409" mass="46164" checksum="2402938CE648E3CF" modified="2010-10-05" version="1">MKKLFTLSLITVVLMQNACTSASKQAAVRNDSVAQTIVASSPLPGADQLSAYLPLLKGKKVGLMGNQTSIVGKDKEHLVDVLLREKVNLKFGFAPEHGFRGNVERGEKVSNDVDPKTGLPLYTLYGGNEKQDSIVKSVDVMIFDLQDVGARFYTYITSLHRVMELCAKHNKELIVLDRPNPNGDQVDGPVRKDDKFKSNVSFHKIAMIHGLTVGELAHMINGEKWLEKGKQCKVTVIPVKNYDHKTMYDLPVIPSPSLPNHLSVRLYTSLCLFEGTDISVGRGTDWPFQVVGYTDPVYGQFTFTPSERAGMVKHVEGKGATNYGLDLRNLNADEQKFTLKYILHFYNKMPDKSKFFVRAEFFDKLAGTDELRKQILAGKSEQQIRDSWKQELSDYKKMRKQYLLYPDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLG8</accession>
    <name>D7VLG8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">hflX</name>
        <name evidence="9" type="ORF">HMPREF0766_11838</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000114.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11838"/>
    <dbReference type="EnsemblBacteria" id="EFK58441">
        <property type="protein sequence ID" value="EFK58441"/>
        <property type="gene ID" value="HMPREF0766_11838"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019597_2_1_10"/>
    <dbReference type="OrthoDB" id="1592033at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="8">
        <location>
            <begin position="204"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="210"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="235"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="256"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="322"/>
            <end position="325"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="363"/>
            <end position="365"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK58441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="396" mass="45243" checksum="B4892FCDA096FF92" modified="2010-10-05" version="1">MARTKIYDTALKPETAVLISVITPDTTEAKAREYLEELQFLVETAGGITNGIFTQKLAYPDKATFIGSGKMEEIKSYIDAEEIDMVVFDDELSPSQLRNIENFFKVKILDRSNLILDIFASHAKTAQAKTQVELAQLQYILPRLTRMWTHLERQRGGIGMRGPGESQIESDRRMILNKISLFKERLKSIDKQNETQRKNRGEMIRVALVGYTNVGKSTIMNMISKSDVLIENKLFATLDTTVRKVVIDNLPFLLSDTVGFIRKLPHHLVECFKSTLDEVREADVLIHVVDISHPNFEDHIHAVNETLKDLGALDKPVITIFNKIDAYKPAVEEGDEGEEREVTLEEFRNSWMGKNSDPAIFISATNKTNVEEFKQKLYDIIVKMHNARYPYNNLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLJ6</accession>
    <name>D7VLJ6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">prfB</name>
        <name evidence="7" type="ORF">HMPREF0766_11866</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11866"/>
    <dbReference type="EnsemblBacteria" id="EFK58469">
        <property type="protein sequence ID" value="EFK58469"/>
        <property type="gene ID" value="HMPREF0766_11866"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_6_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="6">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="283" mass="32072" checksum="A2E6B540FFABCC44" modified="2010-10-05" version="1">MYEFFQSGDATEQELESQYQTALQDIEELEFKNMLSAEEDQLDAILQITAGAGGTESCDWAAMLMRMYIMWGEKHGCKVTEQDSQEGDVAGIKTVTLQFSGNFAYGYLKGENGVHRLVRISPFDSNAKRHTSFASVYVYPLIDDNIEIDVKDSEIEWDTFRSGGAGGQNVNKVETAVRLHHKPTGIIIKNQETRSQLQNKENALRLLKSQLYEIEMRKRQEATAVIEGSKKKIEWGSQIRNYVLHPYKLVKDLRTSVETSNTQAVLDGDIDMFLKAYLMEFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLM9</accession>
    <name>D7VLM9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase family associated with various cellular activities (AAA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11899"/>
    <dbReference type="EnsemblBacteria" id="EFK58502">
        <property type="protein sequence ID" value="EFK58502"/>
        <property type="gene ID" value="HMPREF0766_11899"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_2_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="44"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="323" mass="36052" checksum="EB21A02502FEABC6" modified="2010-10-05" version="1">MPNFESRLDLTELQDKMESVKREVKKVIVGQDQVINMLLMSILSSGHSLIEGLPGVAKTLTAKLIAKTINSTFRRIQFTPDLMPSDVTGSSILDLKSNEFEFRKGPIFGNIILIDEINRAPAKTQASLFECMSERQVTVDGNTYPMDTPFIVLATQNPIEHEGTYRLPEAQLDRFLFKIVVNYPEFSQELTILKEHHAQKAGNKESLVQQVVSSEEIVLFQSQVKLVFAHEDVLNYIAQIIVQTRTNPNLTLGASPRASIAILEASKASAALLGRDFITPDDVKYVAPAILGHRVTLTPEKEMEGFTTEFIIKQIVDGVEIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLP1</accession>
    <name>D7VLP1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TrkA N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ktrA</name>
        <name evidence="2" type="ORF">HMPREF0766_11911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000278.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11911"/>
    <dbReference type="EnsemblBacteria" id="EFK58514">
        <property type="protein sequence ID" value="EFK58514"/>
        <property type="gene ID" value="HMPREF0766_11911"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_3_2_10"/>
    <dbReference type="OrthoDB" id="1768241at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="228" mass="25320" checksum="C668ADD77C407922" modified="2010-10-05" version="1">MKYIVLGLGHFGKSLAIHLTELGHEVIGADKNLTIVEQLKDRVTHTVCMDTTDRDSVSALPLRDSHAVIVAIGEDEGASMLTTALLKQLHVKRIIGRVVSDLQKTVMEAMEIDEYIMPEEEAAERLAMRLDNIDIVDSFKISDKYSIVETKVPAKYIGMTLEQANLTNSYGVIVLTTVNQRDVLEKGKNVKIKEATGIAKSDTMLREEDLLVLFGELSNIKKLIQKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLU9</accession>
    <name>D7VLU9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001600.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12203"/>
    <dbReference type="EnsemblBacteria" id="EFK58211">
        <property type="protein sequence ID" value="EFK58211"/>
        <property type="gene ID" value="HMPREF0766_12203"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134477_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="170" mass="19971" checksum="56D0AC2E7EE3255D" modified="2010-10-05" version="1">MRTIFLITIVSLLFSSCERKEEKKRSNDFSFYLPDADLYITTSKRMEGDFYVMFSKTDSISRLSDSTDYIKCDIEDVPLIIVFDPINKDNIYIKYPYVEKINKKNLNIIKFKKNDFNNKFYHNGIGAGPNTLKNPYKKLYVIPTSYNITFQRDSSFNSQIIIKNGNMWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM27</accession>
    <name>D7VM27_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001237.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12024"/>
    <dbReference type="EnsemblBacteria" id="EFK58032">
        <property type="protein sequence ID" value="EFK58032"/>
        <property type="gene ID" value="HMPREF0766_12024"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151208_2_0_10"/>
    <dbReference type="OrthoDB" id="1457473at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018668">
        <property type="entry name" value="DNA-binding_VF530-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09905">
        <property type="entry name" value="VF530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="74" mass="8747" checksum="FF7CE58FC981AFE6" modified="2010-10-05" version="1">MNEQPNNPLHGVRLDTIIEYLVDHFGGWEGLGKRIQIRCFNENPSLKSSLTFLRRTPWARQKVEELYVRIISHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM30</accession>
    <name>D7VM30_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12027"/>
    <dbReference type="EnsemblBacteria" id="EFK58035">
        <property type="protein sequence ID" value="EFK58035"/>
        <property type="gene ID" value="HMPREF0766_12027"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50339CB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091360_0_0_10"/>
    <dbReference type="OrthoDB" id="1706149at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107419" evidence="1">
        <location>
            <begin position="26"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="262" mass="27865" checksum="7DE86BB3BA1D5171" modified="2010-10-05" version="1">MPVMKKKINSLTTSLPLLLWVSGLATLQAQQAGVNTKNPQAVLHVDAKKDNNPTVQEADDFVVTSAGSVGIGTISPTHKLDIRGKIQIRDGGEQAGSVLTSNASGLARWNYPAVSKVVVNGIFSSNAKVTPDGGATPKYSNVYITLTRGKWIVNAGLTFVEGNRTIFQRCYLSSANNALQQNGFTFLGPAGAQSSYGGIVATNITDRTATGQQRGFVTGSVAIEVTATTATIYLLLQNQPAGAYEFNAQNYLENYFFAKPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMC9</accession>
    <name>D7VMC9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCO1/SenC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_12126</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001454.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12126"/>
    <dbReference type="EnsemblBacteria" id="EFK58134">
        <property type="protein sequence ID" value="EFK58134"/>
        <property type="gene ID" value="HMPREF0766_12126"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1999">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050131_2_0_10"/>
    <dbReference type="OrthoDB" id="1994201at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="PTHR12151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005672184" evidence="3">
        <location>
            <begin position="20"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="45"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="211" mass="24042" checksum="668E31998D64D3B9" modified="2010-10-05" version="1">MRLLYTLTLAAGLFLSACSGNDAKLPIYGDREAVEKTVDGKVVIDTAYHTIPAFSFLNQDSVLITDKNFDNKIYIANFFFTHCPSICPTMQRNLLKVYEKYKGDQRIAFLSHSIDFKYDHPYILKAYANKLGVTNDQWQFVNGSKADIYGIANDYLVFAKEDSNVPGGYDHQGYLVIVDKEKRIRGAYDGTDSEQVDKLLKDLEILFNEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMQ0</accession>
    <name>D7VMQ0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-galactarate dehydratase/altronate hydrolase domain protein</fullName>
            <ecNumber evidence="4">4.2.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UxaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.7" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992727.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12270"/>
    <dbReference type="EnsemblBacteria" id="EFK57197">
        <property type="protein sequence ID" value="EFK57197"/>
        <property type="gene ID" value="HMPREF0766_12270"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029189_0_0_10"/>
    <dbReference type="OrthoDB" id="889365at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008789">
        <property type="term" value="F:altronate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11613">
        <property type="entry name" value="SAF_AH_GD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007392">
        <property type="entry name" value="Gal/Altron_deHydtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044144">
        <property type="entry name" value="UxaA/GarD_SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04295">
        <property type="entry name" value="GD_AH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAF" evidence="3">
        <location>
            <begin position="12"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="548" mass="59469" checksum="4CE51123AF3D6F14" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMQ1</accession>
    <name>D7VMQ1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannitol dehydrogenase domain protein</fullName>
            <ecNumber evidence="3">1.1.1.58</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">uxaB</name>
        <name evidence="3" type="ORF">HMPREF0766_12271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.58" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992728.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12271"/>
    <dbReference type="EnsemblBacteria" id="EFK57198">
        <property type="protein sequence ID" value="EFK57198"/>
        <property type="gene ID" value="HMPREF0766_12271"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027324_1_0_10"/>
    <dbReference type="OrthoDB" id="1442117at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009026">
        <property type="term" value="F:tagaturonate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000669">
        <property type="entry name" value="Mannitol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00084">
        <property type="entry name" value="MTLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol_dh" evidence="1">
        <location>
            <begin position="29"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol_dh_C" evidence="2">
        <location>
            <begin position="214"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="503" mass="56452" checksum="A43387FD7A5B3F9B" modified="2010-10-05" version="1">MILNRKNLEHIQHTGLVKPSADLLDLPEKILQFGTGVLLRGLPDYFIDKANRQGIFNGRILVVKSTSQGGVDAFSTQDGLYTVAIRGIEEGKKIHENIINSSISRVLSATNDWKEILKAAHRPEMQVVFSNTTEVGIVMSEDKVTDMPPSSYPGKLLAFLYERFSAFGGTPESGMVIVPAELISDNATKLQQIVFDLAEQNNLDKQFITWLKENNHFCNTLVDRIVPGKLPQDEQNILEQQLGYTDELTIMAEPFRLWAIESEDSRVAEILSFAQADKGIFIVPSISKFKELKLRLLNGTHTLTCALAILAGFETVREAMQDEAFTAYVKGLMEDEISAAILSDSISREDTASFANSVIDRFSNPSLEHKWQSIAMNYTSKMEMRNRELFEKWYQKYEHVPQHMALGFAAYLLFMNSKNTSDGYCSTVGEKKYMLQDEHAPLLAGYWNDPETLVEKVLADQSLWGMDLNRLPGFATSVKKQLNTLQNSGAKSAIESLQAEKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMX2</accession>
    <name>D7VMX2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992850.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12342"/>
    <dbReference type="EnsemblBacteria" id="EFK57269">
        <property type="protein sequence ID" value="EFK57269"/>
        <property type="gene ID" value="HMPREF0766_12342"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_15_2_10"/>
    <dbReference type="OrthoDB" id="1900922at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="140" mass="16161" checksum="875AB61BA925C589" modified="2010-10-05" version="1">MKISKLSPNFEVIDIRKTVDFYTKNLGFNLIMAVPETQDGIDSAFAENKEYVYALVQKDNVEFMFQRSDTFKDDVVFSKGQTVGATVSFYMEIEGIKGFYENLKSKELEMTELKTAWYGMQEFYVKDLNGYILGFAEKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN11</accession>
    <name>D7VN11_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992905.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12381"/>
    <dbReference type="EnsemblBacteria" id="EFK57308">
        <property type="protein sequence ID" value="EFK57308"/>
        <property type="gene ID" value="HMPREF0766_12381"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092206_2_1_10"/>
    <dbReference type="OrthoDB" id="2019103at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007263">
        <property type="entry name" value="DCC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04134">
        <property type="entry name" value="DCC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="130" mass="15490" checksum="9F36E79EC6B440CF" modified="2010-10-05" version="1">MLHTKNIVLFDGICNVCNGTVNFIMKHDRQHKFYFSSLQSPLGQQVQQQTGHQLDSILYIRQNKVWNKSNAVLYIAKDMGFPWSLCFIFKPLPTSLRDRCYDFIARNRYKWFGKREQCRVPTAEERQHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN14</accession>
    <name>D7VN14_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12384</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992910.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12384"/>
    <dbReference type="EnsemblBacteria" id="EFK57311">
        <property type="protein sequence ID" value="EFK57311"/>
        <property type="gene ID" value="HMPREF0766_12384"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_14_4_10"/>
    <dbReference type="OrthoDB" id="1533572at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107456" evidence="3">
        <location>
            <begin position="20"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="110"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="422" mass="49016" checksum="07ED3DC85F75FB3B" modified="2010-10-05" version="1">MKYLAAISIFITVSFQSFAQQDSVVVRSKEQIEQHFLSSNLELLAGKYKIEQSRAAILQAKLWPNPTFSISEVNLWKNNPVETMSPLIGNWGRNQQVALELEQLIETAGKRKKRVRLEQLNLKNQELEFEETLRNLKFDLRESVIELQKLQGQESLYQSQFELFRNLSEAFEKQWKQGNVSEMEYVRIHSEMLSFENELAEIRASKIDLIKKIKTYSNVEGPESIVLANALQINTYVIPDLLRWKETALENRADFRMASNQLDISRQQLVIEKAERKPNVQLSLGYDRGGNVMPDFIGLGASIELPVFNRNQGNIRIAQLEIEKSTTELTQNKLMIVNEIDATVQRLVQLQRILEKLSGAFDKQLDLSLEKYTRNFQNRNISVMEFVDFVSSYLENKKNLIDRKEQYLKTIEELQYVIGKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN54</accession>
    <name>D7VN54_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992963.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12424"/>
    <dbReference type="EnsemblBacteria" id="EFK57351">
        <property type="protein sequence ID" value="EFK57351"/>
        <property type="gene ID" value="HMPREF0766_12424"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033NH2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1229242_0_0_10"/>
    <dbReference type="OrthoDB" id="2091514at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="225" mass="24564" checksum="A25835640F6FABF6" modified="2010-10-05" version="1">MNIKELIKTLLQSNFGGAQLSDARVEQLAKRLEGKVTTEDELKEKLSLLNELEPFSEKVKEDDRMRSFQSEIEKLKKGAGQSDDKDKGDEGAGGSGAASGAGSEEIPAWAKAIIDGNKTVTEKLAALEGQKVVNDRRSIIQAKLKDADKDYSSKVLRDFGRMNFATDEDFTAYLTDVETDFANHTQTQAESKLGKDNPFAGVGKDGKITEASQAEVDKLFGDIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN70</accession>
    <name>D7VN70_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine-type D-Ala-D-Ala carboxypeptidase</fullName>
            <ecNumber evidence="2">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992983.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12440"/>
    <dbReference type="EnsemblBacteria" id="EFK57367">
        <property type="protein sequence ID" value="EFK57367"/>
        <property type="gene ID" value="HMPREF0766_12440"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109248_0_0_10"/>
    <dbReference type="OrthoDB" id="1584918at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039561">
        <property type="entry name" value="Peptidase_M15C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13539">
        <property type="entry name" value="Peptidase_M15_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M15_4" evidence="1">
        <location>
            <begin position="68"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="163" mass="19049" checksum="E644B34909CED200" modified="2010-10-05" version="1">MADRRLQYADEITLARIELMHPKIREEVREIYLQINTALPKGVRLRLSQTLRTFKEQDELFNKRPKVTNAKGGQSIHNYGLAFDIVILYDKDSNGSFETASWALDINFMKVVNFFKSKGWTWGGDWKSFKDYPHFEKTFGNTWQSLIVKKSAKDSNGNYYVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNE8</accession>
    <name>D7VNE8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">Elongation factor Ts</fullName>
            <shortName evidence="5">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">tsf</name>
        <name evidence="9" type="ORF">HMPREF0766_12518</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the EF-Ts family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993085.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12518"/>
    <dbReference type="EnsemblBacteria" id="EFK57445">
        <property type="protein sequence ID" value="EFK57445"/>
        <property type="gene ID" value="HMPREF0766_12518"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047155_0_0_10"/>
    <dbReference type="OrthoDB" id="1405357at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="8">
        <location>
            <begin position="74"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="5">
        <location>
            <begin position="83"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK57445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="278" mass="29866" checksum="5E1DE48A9BCC9EE8" modified="2010-10-05" version="1">MSVQISASDVNKLRQQTGAGMMDCKKALVEANGDFEAAIDYLRKKGAKVAASRQDRESNEGVIIAKASADKKSGIVVEVNCETDFVAKNADFVAFAESIADVAIANQPASLEALKALEIDGRPIAELLIDQTGKIGEKIEVSKYEAVQAEEVIAYIHGNYRLGVLVGLSAAGEGVEEAGKDVAMQIAAMNPVAIDKDGVDTKTIERELEIAKEQIRAEGKPEEMVEKIAQGKLNKFYKESTLLNQEFVKDSSKNIAQFLDSVAKGLTVSAFKRVQLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNS6</accession>
    <name>D7VNS6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3347 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993266.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12646"/>
    <dbReference type="EnsemblBacteria" id="EFK57573">
        <property type="protein sequence ID" value="EFK57573"/>
        <property type="gene ID" value="HMPREF0766_12646"/>
    </dbReference>
    <dbReference type="GeneID" id="66688600"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101306_0_0_10"/>
    <dbReference type="OrthoDB" id="1905459at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021782">
        <property type="entry name" value="DUF3347"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11827">
        <property type="entry name" value="DUF3347"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107086" description="DUF3347 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3347" evidence="3">
        <location>
            <begin position="82"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="221" mass="23988" checksum="720909BA72F07B55" modified="2010-10-05" version="1">MKNLTLSIIAVIMAFVTVSCNQASNKNEQSSSDTAVVSQEQSASQPKEDDTVAAPVVSETPSGQEAKATGKEEAKNFSIAPIVTDYLSLKNALVSDDDKAAASSGKKLLATLNKVDMKAVPADKHKKYMDIADDAKEHAEHIGENVGNIHHQREHLASLGEDLKDLIDLFGTSQTLYQDHCPMFNDGKGAVWFSENKEIKNPYYGSKMLTCGKVEKTINSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNT6</accession>
    <name>D7VNT6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_12656</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993279.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12656"/>
    <dbReference type="EnsemblBacteria" id="EFK57583">
        <property type="protein sequence ID" value="EFK57583"/>
        <property type="gene ID" value="HMPREF0766_12656"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="138"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="490"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1082" mass="122045" checksum="38398C715DAE2ADB" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNX3</accession>
    <name>D7VNX3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">ureF</name>
        <name evidence="4" type="ORF">HMPREF0766_12693</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993340.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12693"/>
    <dbReference type="EnsemblBacteria" id="EFK57620">
        <property type="protein sequence ID" value="EFK57620"/>
        <property type="gene ID" value="HMPREF0766_12693"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0830">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049215_4_2_10"/>
    <dbReference type="OrthoDB" id="1942614at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="228" mass="25864" checksum="FF431C354DCE9EA8" modified="2010-10-05" version="1">MNPLLTLLQINDSVFPIGSFTHSYGLETYIHERIVHNSTTAQEYAESMLRHSVFYNDAAFFHQAWTLCEDKFSKVALLKLDNLVTSLKSPAEIREASRKLAIRFLKVVESFKSVKRCRTYLEAIQSGEAGGHYAIALAMYAQSQQIAYSDALSAFYYNTLNGMVTNCAKLVPISQMDGQKMMFNLQGLIQELVGKQKNMDPDMLGNCCVAQDVRCMQHEKLYTRIYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP14</accession>
    <name>D7VP14_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GDSL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">estA</name>
        <name evidence="3" type="ORF">HMPREF0766_12734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993419.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12734"/>
    <dbReference type="EnsemblBacteria" id="EFK57661">
        <property type="protein sequence ID" value="EFK57661"/>
        <property type="gene ID" value="HMPREF0766_12734"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051989_6_1_10"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107094" evidence="1">
        <location>
            <begin position="23"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="56"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="228" mass="26471" checksum="1EDF8D3E7BDEF9B3" modified="2010-10-05" version="1">MEKKRIYMILLLCLQMITGLFAQEAVIDSSYANSYYQKRQAYYDQLPKVKNAIVFLGNSITEAGQWYEIAQVSHIINRGISGDVTYGILNRLSSITALQPKKIFMTVGINDVKRGIPPEYTVQNIERIIKRVRKDSPKTKLLIQSVLPVRESMFTDGYQRVTNQKVVLLNEQIKTLCQQYDVPFIDVHQAIFMDKEGRLKQELTTDGIHLRPEAYIQWIDYLKTKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPB4</accession>
    <name>D7VPB4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993594.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12834"/>
    <dbReference type="EnsemblBacteria" id="EFK57761">
        <property type="protein sequence ID" value="EFK57761"/>
        <property type="gene ID" value="HMPREF0766_12834"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_2_0_10"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="285" mass="31906" checksum="E20C9ACD2FC18D2D" modified="2010-10-05" version="1">MPVSKRYILASDIGGSHITSAIVDTADWSILFESVTRNRVDSSSDAKSIFQNWASNLKETITKSPEEIKQLGIAMPGPFDYEKGISLMHNQDKYDSLFQLDTSAGIREAMGNSSIEIRYINDAAAFLQGEIFASKLDNEEKILGITLGTGLGSAVWSNGNKAFDADLWNTAYRDSIFEEYLVTRWFTRRFEELTGNKAEGLKEILEQHQDEAEFATLIQEYSAQLLDFLKFFSEKYNCTHYIIGGNIAKALDIITSYRTEEFSAYTIGRSNLDEKAAIIGAASIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPB9</accession>
    <name>D7VPB9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclease-like protein</fullName>
            <ecNumber evidence="2">3.1.31.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nucI</name>
        <name evidence="2" type="ORF">HMPREF0766_12839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.31.1" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993605.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12839"/>
    <dbReference type="EnsemblBacteria" id="EFK57766">
        <property type="protein sequence ID" value="EFK57766"/>
        <property type="gene ID" value="HMPREF0766_12839"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046484_5_1_10"/>
    <dbReference type="OrthoDB" id="1719840at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002071">
        <property type="entry name" value="Thermonucl_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01284">
        <property type="entry name" value="TNASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="1">
        <location>
            <begin position="29"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="161" mass="18457" checksum="69DA189FBA094B88" modified="2010-10-05" version="1">MKILLRCLPLFFIAFTSFKDPSKRLETVPDHSYIVRRVIDGDTFVIEDGSSKGTKVRFIGIDAPESRNTGRKLIGYFGAESKKYLTERLKNKHVSLTFDVAKRDRYGRLLAYVYIDSILLNAELVEKGYSVTMTVPPNVKYAAYFRELEGKARLHKAGLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPJ4</accession>
    <name>D7VPJ4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance MFS transporter, drug:H+ antiporter-2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_12914</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993758.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12914"/>
    <dbReference type="EnsemblBacteria" id="EFK57841">
        <property type="protein sequence ID" value="EFK57841"/>
        <property type="gene ID" value="HMPREF0766_12914"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_0_10"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="526" mass="58254" checksum="DE99FF4ABF7D58AE" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPJ8</accession>
    <name>D7VPJ8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_12918</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12918"/>
    <dbReference type="EnsemblBacteria" id="EFK57845">
        <property type="protein sequence ID" value="EFK57845"/>
        <property type="gene ID" value="HMPREF0766_12918"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_2_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="118"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="463"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1061" mass="117674" checksum="2AFA5F11B7AA3EAF" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPP8</accession>
    <name>D7VPP8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DEAD/DEAH box helicase</fullName>
            <ecNumber evidence="11">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rhlE3</name>
        <name evidence="11" type="ORF">HMPREF0766_12968</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="11"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993838.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12968"/>
    <dbReference type="EnsemblBacteria" id="EFK57895">
        <property type="protein sequence ID" value="EFK57895"/>
        <property type="gene ID" value="HMPREF0766_12968"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_28_3_10"/>
    <dbReference type="OrthoDB" id="643629at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="49"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="235"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="391"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK57895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="435" mass="48956" checksum="CA9F60DB0397736E" modified="2010-10-05" version="1">MQLIDTDKKVSIIKFNNLQFKDLKLIAPILKALDASGYQNPTPIQEQAIPIIFQRKDLLACAQTGTGKTAAFAIPILQMLTYSKEKTAQKRIRTLVLTPTRELAIQIKENFDAYSKELPIRNLVIYGGVGQQPQRDALRKGIDILIATPGRLLDLYNQGFIDLKQLEYFVLDEADRMLDMGFIHDVKKVISIIPKKRQTLLFSATMPAEIQKLASHILEDPSKVEVTPESTTAEKIQQSVYFVSKSDKRHLLTHLLKSENIEHTLVFSRTKHGADRIAKDLAKQGIQAAAIHGNKSQSARQNALNNFKDRKLRVLVATDIAARGIDIDDLSYVINFDLPNIPESYVHRIGRTGRAGKDGKAISFCDDEEYAYLLDIEKSIRMEIPRVEDQPYSLHISPKKPGQAAKKPGTDKNRSKARSGASKKPFRRGKFKTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPT3</accession>
    <name>D7VPT3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sigma factor regulatory protein, FecR/PupR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993885.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13003"/>
    <dbReference type="EnsemblBacteria" id="EFK57930">
        <property type="protein sequence ID" value="EFK57930"/>
        <property type="gene ID" value="HMPREF0766_13003"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050192_1_0_10"/>
    <dbReference type="OrthoDB" id="1381035at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032508">
        <property type="entry name" value="FecR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16344">
        <property type="entry name" value="DUF4974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FecR" evidence="1">
        <location>
            <begin position="196"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4974" evidence="2">
        <location>
            <begin position="330"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="401" mass="45142" checksum="3C0F1FE567D22EC3" modified="2010-10-05" version="1">MKNTTELSLLLKKYLTKRIDKEEYEILFLQLSELSNDELKKIVQQELGSVDADTDLADELIDQRLLRIYGKINSTIADKSVASISSDASKPSTGIFRTWSWIAAAASILLVCGLFFLNRPETADIHPGLVQKSNDVHPAVSAATLTFENGKKINLDTAVTGVIYEEKGFRIVKSKDGQISYEYDNQHEIETKTNIIETSKAAYTMVVLPDGSKVHLNAMSSIRYPVTFRGDKREVTLVGEGFFEVVKNSRQPFIVHTEGQDVEVLGTTFNINTYDTKKGVKTTLVEGKVSVTLPDKTSMILHPGEQALARDVITVRHVNVEEISAWKDGKFVFNNTSLLSVISEIERWYNVEFVFADKNFKDEPLSGSISRDVMLSDLLDVIQMNTSYKFKIEERRIMVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPU1</accession>
    <name>D7VPU1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_13011</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993897.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13011"/>
    <dbReference type="EnsemblBacteria" id="EFK57938">
        <property type="protein sequence ID" value="EFK57938"/>
        <property type="gene ID" value="HMPREF0766_13011"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_0_0_10"/>
    <dbReference type="OrthoDB" id="248533at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="48"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="283"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="530" mass="60887" checksum="B4764EBE73F109AD" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPZ9</accession>
    <name>D7VPZ9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993966.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13053"/>
    <dbReference type="EnsemblBacteria" id="EFK55850">
        <property type="protein sequence ID" value="EFK55850"/>
        <property type="gene ID" value="HMPREF0766_13053"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033HEZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_667142_0_0_10"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="412" mass="47075" checksum="FE5BA30CA5F57057" modified="2010-10-05" version="1">MRLNGYFKGIIFSFVVFILGSVTSCKRDEEPLKLPLEESENPNEQILSMQPFREVIINADVDGNYEGQLDPERVFSLSQDKRAYCHPDVQYFPQGFRGYRYWMVFTPYFGAVSGFSKYSAFENPTVVTSNDGINWDAPAGVKNPLIKCPAPQESFSGKPDDEDARGYWSDVDWEFYNNKFYLYYRSSWVSARALQSRGSKSTNNAAKLSKGDPQRAVLRQTSGDGVNWSPLEVCYTSDEPATPQNNFLLSPTVLHNGREFVSYEVLNNNLPDKFPGNKASYILKRTSADGVDFTSYKQGQWVQFANEPWLKLSDQYSPWHVQACMYDDYYFLIVNVGTVKKSMGDALYLAYSRDGVNFRVCKKAIEERNAYRSCVFPVSSDKNTIYLGAMVANTQGHFKYTELKIRKDKMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQA3</accession>
    <name>D7VQA3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">3-dehydroquinate synthase</fullName>
            <ecNumber evidence="10">4.2.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aroB</name>
        <name evidence="10" type="ORF">HMPREF0766_13157</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="10"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994128.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13157"/>
    <dbReference type="EnsemblBacteria" id="EFK55954">
        <property type="protein sequence ID" value="EFK55954"/>
        <property type="gene ID" value="HMPREF0766_13157"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001201_0_1_10"/>
    <dbReference type="OrthoDB" id="1677032at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="9">
        <location>
            <begin position="61"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK55954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="355" mass="39748" checksum="62D1B575A2DD5028" modified="2010-10-05" version="1">MHVINSLGYQVVFDDTLASLRTFLAEREYSKILVLVDRNTNDHCLPVLQMVLNDVKDYDIIEVDPGEENKNIDFCIGVWKTMLDFGADRKSLMINLGGGVVTDMGGFAASTFKRGLDFIQIPTTLLSQVDASVGGKTGIDLDNVKNIIGTFTQPQAVFINTNFLQTLDNRQLKSGFAEVIKHGLIFDRELYTNIKGLTDVRGISTDVIFRSVEIKNEVITQDPTEKGLRKILNFGHTIGHAIEGFSLFNDDQPLLHGEAIAIGMICEGYLSHKLAGLSKEELDDLVVTFRNHYPDYRISIENYDEFIALMKNDKKNAGSKIGFALLTGIGSCTYDHYVEEELIIESLDFYRELIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQB3</accession>
    <name>D7VQB3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">trpS</name>
        <name evidence="9" type="ORF">HMPREF0766_13167</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994158.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13167"/>
    <dbReference type="EnsemblBacteria" id="EFK55964">
        <property type="protein sequence ID" value="EFK55964"/>
        <property type="gene ID" value="HMPREF0766_13167"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029244_0_0_10"/>
    <dbReference type="OrthoDB" id="951354at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK55964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="332" mass="37432" checksum="46F97C45D448123B" modified="2010-10-05" version="1">METVVSGIRSTGKLHLGNYYGALSNFVKMQNEYNCFFFIADLHSLTTHPTPHGLQQTVRQVVVEYLAAGIDPEKSTIYIQSDVPEVAELYLYMNMNAYMGELERAASFKDKVRADPNNVNAGLLTYPVLMASDILIHHGTKVPVGKDQEQHLEMTRTFGNRFNRLYEVDYFKEAFAFSYSDKLVKVPGLDGQGKMGKSNGDANCIYLSDTPDAIRKKVMRAVSDGGPTEMNQVKPEPIQNLFDLMKVVSPASTVQHFDDLYNKCEIRYGDFKKQLAEDMIIATEDVRSRIEEISADNDYISKVVKLGADKAGESARKTIKEVREIIGFKKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQS3</accession>
    <name>D7VQS3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-glutamate methylesterase CheB</fullName>
            <ecNumber evidence="3">3.1.1.61</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheB</name>
        <name evidence="3" type="ORF">HMPREF0766_13327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.61" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994452.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13327"/>
    <dbReference type="EnsemblBacteria" id="EFK56124">
        <property type="protein sequence ID" value="EFK56124"/>
        <property type="gene ID" value="HMPREF0766_13327"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_51_2_10"/>
    <dbReference type="OrthoDB" id="1655418at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheB-type methylesterase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="189" mass="20972" checksum="F50EF9C399F14058" modified="2010-10-05" version="1">MLKQTDIFLIGGSAGSLKVILEVLPGLRKGLSFPIVIILHRKPYPDSILNALLSSYTDVQVYEVEDKMTLENGCIYVVPPDYHLLFENKTLVSLDSSEKMNYSRPSIDVTFQSAAEVFEENTVALLLSGANADGVEGLDCIKHNNGIILVQDPQTAEVDYMPRQAVSRVQVDYLLRPEELAVFINQLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQV1</accession>
    <name>D7VQV1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994488.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13355"/>
    <dbReference type="EnsemblBacteria" id="EFK56152">
        <property type="protein sequence ID" value="EFK56152"/>
        <property type="gene ID" value="HMPREF0766_13355"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503196E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134903_1_0_10"/>
    <dbReference type="OrthoDB" id="1927917at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="154" mass="18079" checksum="BE3487E29869C525" modified="2010-10-05" version="1">MYSTLLILHSLVRWLVLAFIIYAVYRSYTGYIKNRIFSNTDNAVRHWTATIAHIQLMIGMLLYIKSPVVKYFWSDVKKAIQQADLTFYSIIHFILMLLAIITLTLGSALAKRKNTDKEKFRTMLIYFSIALIIIFIAIPWPFSPLSNRPYFRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQV7</accession>
    <name>D7VQV7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_13361</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994495.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13361"/>
    <dbReference type="EnsemblBacteria" id="EFK56158">
        <property type="protein sequence ID" value="EFK56158"/>
        <property type="gene ID" value="HMPREF0766_13361"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_3_5_10"/>
    <dbReference type="OrthoDB" id="406005at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="22"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="300"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="484" mass="54455" checksum="30D58984CEB9C54F" modified="2010-10-05" version="1">MKLLLYSSVAATLILSSCGKSFLEVDPIGKLGKEQVFRDIVGLKNALDGSYNLMARYHMNEYGVYGDLRGDDVAFRTGISNPVMQTEFNYVANDQDEAGATRLMWGNGYAALNNINNIINGAEPFLESSIDKAQATSILGQALLLRALCNFDMTNIYAQQYNYSPDASHLGIPILLKTPPAGTHVARESVSAVYAQILADIEQCIQLLSQNPNVPTKIYASVDAAKALRARIYLYMGQYQNVVNQTSELITPNKYPLVSSADYKKMFTASAQRTDYTSIASEVIWQFNLEKYAKGTVQHLFSEPVEYQYYAAPGYVSLFSDQDIRKTMLQIDPATNYYRSIKYGKEDGVINDNWPLNVKVVRSAELYLNRAEANFRLGNYAEAVSDIKILQARARNVSTDLITIAYNTPEELFAIIKLERRKELGFENQRIYDIMRYKESLNRGTGCTSNLCQLTYPNDRFIMPIPRSELDINPLMQPNPTVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQW5</accession>
    <name>D7VQW5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994506.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13369"/>
    <dbReference type="EnsemblBacteria" id="EFK56166">
        <property type="protein sequence ID" value="EFK56166"/>
        <property type="gene ID" value="HMPREF0766_13369"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9M8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082062_1_0_10"/>
    <dbReference type="OrthoDB" id="1970612at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="243" mass="28297" checksum="06CDC42512476008" modified="2010-10-05" version="1">MVRYKLLILFSMIFGNMCLYGQEIHSALQLRNSHLWRGIEVATGLVYTGDIHVDYKNFYGGFWAGGDADGSYKEFNNYIGYKNKHLTVELWDIYNFSPEATYNNDEFFNYTADETGRFWDFRSYYTISDRIPLVLSWNTVVFGRDRNSGNTANKYSSFVSGEYPVFKKDDLELRARLGYSFALHTSGEKNNFFSRKAGFNELSLMLSKPFKIGNYQFPLGLWGMWNPVDNRALLQFSVQVYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR85</accession>
    <name>D7VR85_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative holliday junction resolvase Hjc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_13489</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994662.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13489"/>
    <dbReference type="EnsemblBacteria" id="EFK56286">
        <property type="protein sequence ID" value="EFK56286"/>
        <property type="gene ID" value="HMPREF0766_13489"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1787">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086368_0_0_10"/>
    <dbReference type="OrthoDB" id="1124258at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="4">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="281" mass="31976" checksum="34311F34E195646C" modified="2010-10-05" version="1">MQVKKHSGELVPFEPNSLKQSLSRSGASDQDVEKVFQSIQQNLYDGISTKELYKLAFDLLKNQRDSYAARYSLKKALRELGPEGFYFEKWIARLFADEGYKSINGQTVQGHAVSHEIDVVALKGDKMLAVECKFRNDIEAKISVTTPMYFMSRVKDISNLPFNFFGGEYTFTEGWLVTNAYFTSDSTDFGEYYKMNLLSWNYPKNSSIKVRVDDNGLYPVTCLTCLSDTEKGMLLKNQCILVKELLDNPSILQSIHVNPDKAQKILKEANELVNSPVETEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRB4</accession>
    <name>D7VRB4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoserine aminotransferase</fullName>
            <ecNumber evidence="6">2.6.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphohydroxythreonine aminotransferase</fullName>
            <shortName evidence="6">PSAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">serC</name>
        <name evidence="9" type="ORF">HMPREF0766_13518</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 6 7">
            <text>2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="6">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6 7">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994700.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13518"/>
    <dbReference type="EnsemblBacteria" id="EFK56315">
        <property type="protein sequence ID" value="EFK56315"/>
        <property type="gene ID" value="HMPREF0766_13518"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034866_0_2_10"/>
    <dbReference type="OrthoDB" id="996960at2"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PTHR43247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01364">
        <property type="entry name" value="serC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="6 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="8">
        <location>
            <begin position="4"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="74"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="232"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK56315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="355" mass="39046" checksum="A83482BAED30E35C" modified="2010-10-05" version="1">MKHNFGAGPCILPKEVFQEAAQAVIDFNNTGLSILEISHRSKDFEAVISETERLVRELLNVPQGYSILFLQGGASTQFAMVPLNLLPEGGKAAYFDTGVWATKAAKEAKKIGQVEVVASSSDRNYTYIPKNITVPSDAAYFHYTTNNTIYGTEVFDIPQSAVPVVADMSSDILSREINVADYGLIYAGAQKNMGPAGVTLVIVKDELLGKTGRTLPSIFDYDSHIKGGSMYNTPPVYSIYVSMLNLRWLKAKGGISVIEQENIVKARTLYDEIDRNSLFKGTAEVEDRSRMNVTFVMNNPELEGAFLDLAKERGHIGLKGHRSVGGFRASIYNALSISSVNALVDTMQEFEEKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRE1</accession>
    <name>D7VRE1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994732.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13545"/>
    <dbReference type="EnsemblBacteria" id="EFK56342">
        <property type="protein sequence ID" value="EFK56342"/>
        <property type="gene ID" value="HMPREF0766_13545"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2510">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120467_0_0_10"/>
    <dbReference type="OrthoDB" id="1668457at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="137" mass="14834" checksum="D78ABAA1DF59633A" modified="2010-10-05" version="1">MWKYYALLSALFAALTAILAKIGVKGVNSNLATAIRTLVVLFIAWGIVLLSGEIKEVKTLNKENWLFLTLSGIATGLSWLFYFKALQTGDVSKVAPIDKLSVAIAIGLSFWLLKEPVDVKTIVGGLLIVAGTLVIIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRG2</accession>
    <name>D7VRG2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994757.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13566"/>
    <dbReference type="EnsemblBacteria" id="EFK56363">
        <property type="protein sequence ID" value="EFK56363"/>
        <property type="gene ID" value="HMPREF0766_13566"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8RB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079006_0_0_10"/>
    <dbReference type="OrthoDB" id="1506877at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107835" evidence="1">
        <location>
            <begin position="21"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="294" mass="33084" checksum="0680E5A268C61DBC" modified="2010-10-05" version="1">MRKILLSLTAAALCLSSVSAQEMGDRNSEIGKSIFKTKYSRTESNKGKIFVHWGYNFSSYAKSDITFKGPGYNFTLHDVKAGDRPTKLSMTYLDPGRLTIPQFNFHFGYFIKDNYSLSLGWDHMKYVVDIPQRVKISGFIDPEISSPGIPTGDKAGSYNGEMITVDSSMLTFEHTDGYNFAALGLERYDDIIVNRQGKQVLTMESGVEAGLLIPRSDVHLFGEGANHFWNIAGYGGAAKVGLQYRFYKGLYLQGSFKTGYTELTNIRTTGRRGVDKAQQGIWFFENYWVLGFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRI1</accession>
    <name>D7VRI1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ssb2</name>
        <name evidence="5" type="ORF">HMPREF0766_13585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994780.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13585"/>
    <dbReference type="EnsemblBacteria" id="EFK56382">
        <property type="protein sequence ID" value="EFK56382"/>
        <property type="gene ID" value="HMPREF0766_13585"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078758_2_3_10"/>
    <dbReference type="OrthoDB" id="1942216at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="131" mass="15094" checksum="472EBD14447506AD" modified="2010-10-05" version="1">MNTLRNSIQLVGRLGIDPVIKATAKGSKMAQLRLATNEVYKNAQGEWVENVLWHNLVVWGNLTQVVEHKCFKGTQIMIEGMLTYRDYEDKDGNKKFVTEVKVRQLQILDKNSNPRDHADLLQEQVEQDLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRJ8</accession>
    <name>D7VRJ8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fmt2</name>
        <name evidence="2" type="ORF">HMPREF0766_13602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994802.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13602"/>
    <dbReference type="EnsemblBacteria" id="EFK56399">
        <property type="protein sequence ID" value="EFK56399"/>
        <property type="gene ID" value="HMPREF0766_13602"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058336_0_4_10"/>
    <dbReference type="OrthoDB" id="902542at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="233" mass="26722" checksum="D158A7022FFF6418" modified="2010-10-05" version="1">MKEDKILRAFENKTWQEIKVKDSWQIFKIMSEFVDGFEKLAKIGPCVSIFGSARTPREHKYYQMAVDIGKLLTERGYGVISGGGPGIMEAANKGAYEAGGKSVGLNIELPFEQFHNKYIDRDKLLEFNYFFVRKVMFMKYSQGYIVMPGGFGTMDELFEAITLIQTGKIARFPIVLVGSEYWGGLIDWVQNTMLGNAYISEEDLKLYRVVDSAEDAAEHIFRFYDKYLLKPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRQ2</accession>
    <name>D7VRQ2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994934.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13656"/>
    <dbReference type="EnsemblBacteria" id="EFK56453">
        <property type="protein sequence ID" value="EFK56453"/>
        <property type="gene ID" value="HMPREF0766_13656"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033DXU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_792027_0_0_10"/>
    <dbReference type="OrthoDB" id="1401732at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="350" mass="38837" checksum="07ABD8B65F599557" modified="2010-10-05" version="1">MKSKNNNPSLIRIQMFNTQIRIKNMNKVYTLLCALFCLAVTFSSCTKTEELTPLPEDKMLEYKVINLTDDQVIYGAIDNQKNTITVYLPFYYGLSVIDPEIKLSNGAKLKEEILPIQVEATGTTYTVTAANGISRTYTLHIVLQSTPSLAVSWQTPLALSQSPGKAMPAILGNFAHSNAKLVKVTLINQENQKRYSMGVNSASIMTSGNDLYLLRFNGTEYIDRIPADITNGTYKVEVQSLGHTSLIAEPLTITYVQPDVYLPKSSIDLKKTDEWEIVPQSNTVFLGLQKVTATVNGKDYVLPVKSWSRTALKVGFPTDFPGGNLPAVTVRFDFEGWKSVTLSAWLNITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRT3</accession>
    <name>D7VRT3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitroreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995019.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13687"/>
    <dbReference type="EnsemblBacteria" id="EFK56484">
        <property type="protein sequence ID" value="EFK56484"/>
        <property type="gene ID" value="HMPREF0766_13687"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_4_1_10"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02149">
        <property type="entry name" value="NfsB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033878">
        <property type="entry name" value="NfsB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="211" mass="24248" checksum="B8ABE0028427E2F3" modified="2010-10-05" version="1">MSLLEDLSWRYATKKYDPSKKVSTEDVHKIIEAARLAPTSSGLQQFRVLLITNQELKEKIVPVAMDQQIIADCSHLLVFAAWDQYTEERIDEIYNRTTDERELPRGRFSSYTDRLKSLYLQQSAEENFVHTARQAYIGFGLAIAQAAELKIDTTPVEGFNNQQLDELLGLTEKGLKSVTLLPIGYRDNEGDWLVNMKKVRNPLSEFIIEYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRV8</accession>
    <name>D7VRV8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gpo</name>
        <name evidence="7" type="ORF">HMPREF0766_13712</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995077.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13712"/>
    <dbReference type="EnsemblBacteria" id="EFK56509">
        <property type="protein sequence ID" value="EFK56509"/>
        <property type="gene ID" value="HMPREF0766_13712"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029507_2_2_10"/>
    <dbReference type="OrthoDB" id="1635499at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="PTHR11592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="163" mass="19267" checksum="1B915B672794804C" modified="2010-10-05" version="1">MQSVYNFHALEFNGEKKSLEDYHDKVLLIVNTASKCVFTSQYKALERLYQKYKQQGFEVLAFPSNNFNQQEPLTGRRLETFCRLQQQVTFPVFKRTHVIGEYVDPLFKYLSHKELNGSVDVKPLWNFHKYLINRKGEVVDFFYPFTGPNSSRITRKIEALLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRW8</accession>
    <name>D7VRW8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cobA</name>
        <name evidence="7" type="ORF">HMPREF0766_13722</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995103.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13722"/>
    <dbReference type="EnsemblBacteria" id="EFK56519">
        <property type="protein sequence ID" value="EFK56519"/>
        <property type="gene ID" value="HMPREF0766_13722"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0007">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_7_0_10"/>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="252" mass="27460" checksum="74C0EE13753638C9" modified="2010-10-05" version="1">MNRQAKVTLVGAGPGDPDLISVKGLRAIQHANVILYDALISGELLDHARLDCVKIYVGKRAEQLSASQDEINRLLVDYAVNYGNVVRLKGGDPFVFGRGGEEIDFLREHNIETEVIPGISSSIGLTGLQQIPLTYRGISESFWVITGAKSDGSMSSDLELAVRSNATVVVLMGYGKLREIVALYQRHKRGDLPVALIQNGSLPNEKVVLGTIDDILDESQERRIGVPAIIVLGEVVAKHHEFNKIKEQALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS67</accession>
    <name>D7VS67_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13821"/>
    <dbReference type="EnsemblBacteria" id="EFK56618">
        <property type="protein sequence ID" value="EFK56618"/>
        <property type="gene ID" value="HMPREF0766_13821"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3157938_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="48" mass="5799" checksum="042787E6552B3D22" modified="2010-10-05" version="1">MPYKAENLKSLNVIINSVKHKNTFLGWKQEKTRAKITFNKMKRRYTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS76</accession>
    <name>D7VS76_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSCyt1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995373.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13830"/>
    <dbReference type="EnsemblBacteria" id="EFK56627">
        <property type="protein sequence ID" value="EFK56627"/>
        <property type="gene ID" value="HMPREF0766_13830"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_583754_0_0_10"/>
    <dbReference type="OrthoDB" id="1071166at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011429">
        <property type="entry name" value="Cyt_c_Planctomycete-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07635">
        <property type="entry name" value="PSCyt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="PSCyt1" evidence="2">
        <location>
            <begin position="191"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="479" mass="53141" checksum="C3B7573E6089AF86" modified="2010-10-05" version="1">MIFIEELLSFTGRWHPVLVHLPIGMLLLAFIFAVFARFERYRYLSSAIPFSLLFGAGAAILTCITGYLLSLDGGYDTSVLSFHQWLGIAVAVLSFWTYTLYKSAHTDTGLWAKLVKYRFFFLVTVVALLGATGHFGGTLTHGKGYMKDALPSAIKKIAGIQAGEEKLMLLENVQEAPVYDAIIQPILQQRCQSCHGDKKKEGGLALHNRESILKGGEEGSVLVAGKPDKSELYARLILPEGHEGRMPPKGRTPISAEQIQLIGWWIEQGADFEKKTKDLKQNDKIAAILKSLEEGDSSSKSAYAALPDAPSLPEDAIQQLQLKGIKVIPLSADNNYVMVNAINYPEFSDADMQDLLKMKDNIVQLKLGHTAISDKALSEIAKLPVLMKLHLEHTAITNEGLKYLKGHKNLYYINLYKTKVSDEGLSYLQNIPRLEQVYVYQTGVTPGGIDKVRQTLSKSNVDTGNYQLPFLATDTTRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS81</accession>
    <name>D7VS81_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mandelate racemase/muconate lactonizing enzyme, N-terminal domain protein</fullName>
            <ecNumber evidence="2">4.2.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.6" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995393.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13835"/>
    <dbReference type="EnsemblBacteria" id="EFK56632">
        <property type="protein sequence ID" value="EFK56632"/>
        <property type="gene ID" value="HMPREF0766_13835"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4948">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_3_2_10"/>
    <dbReference type="OrthoDB" id="1825548at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008869">
        <property type="term" value="F:galactonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="133"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="388" mass="43276" checksum="5C564E070AD45B60" modified="2010-10-05" version="1">MKIVDVKVWLVEGVKYNWTLLKIYTDTGHTGVGEATNWPGSPIVFEAAKHAGQRIIGLDPMRTDFIWTKLYRDLNWIGPYGASMCAISGIDMALLDLKAKVLGVPCYELLGGAFRKDILLYANYWFTGGGHNKADYAAQALKVKEAGFTGLKFDPFAHTNYLYGEDLSSNLTLTSEQQELAFEVSKAVREAVGPDVDIMIETHAMLNFRVAVKMAERLSTLDITWYEEPAGPESADTLRAMRERIPSGVSICVGERHYTRHGIRPVLEKNVCDIMMPDITRCGGPSEMKRMATMMEAYNVLLAPHNPNGPLSTLASAHVCAAIPNFFRQEFMFNDVPWRDEVIDQPIADMINNGVLTLSERPGLGVDLIEEEMQKHPGILEPRPGFYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSD6</accession>
    <name>D7VSD6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4274 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995513.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13890"/>
    <dbReference type="EnsemblBacteria" id="EFK56687">
        <property type="protein sequence ID" value="EFK56687"/>
        <property type="gene ID" value="HMPREF0766_13890"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033BBB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1092637_0_0_10"/>
    <dbReference type="OrthoDB" id="1976138at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025369">
        <property type="entry name" value="DUF4274"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14096">
        <property type="entry name" value="DUF4274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4274" evidence="1">
        <location>
            <begin position="12"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="246" mass="29128" checksum="824B39C3A61ADE2D" modified="2010-10-05" version="1">MDQLGELINDKTSEELHYLATRHNWDNGVKVLQRITESSACSEATALELFWLAQPQDFQQYKLDITLKDEYQNEVFVLLKIILRNYPDSFYQKTAIQFDPAPFYENELTVPDWIFQKTNGEDSYIYYEEDEIEDWFDTDWKSNIQRAESAIELFNIAWFMDEPEQAALILEHPLCDKGIAVLVFWRLYNECAVYTETNGKLKEIIQDILNNAYPEVLSYDPKTDEKVDYKNTKIVWEIPEIFRKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSF0</accession>
    <name>D7VSF0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane insertion signal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995541.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13904"/>
    <dbReference type="EnsemblBacteria" id="EFK56701">
        <property type="protein sequence ID" value="EFK56701"/>
        <property type="gene ID" value="HMPREF0766_13904"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1155802_0_0_10"/>
    <dbReference type="OrthoDB" id="583204at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107881" evidence="1">
        <location>
            <begin position="22"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="234" mass="26136" checksum="F97C6C391EFD39DB" modified="2010-10-05" version="1">MRRKYSILLVSLLSVATQIYASTTDPVTITPKFQQRKNSPFYNPWFAGAGVGGQIYFGDHNKQLPFGKRITPNFDLYAGKWINANTGIRAGINGFQIKGLTQNGSHSTGEVYNAAERLQKQEFKYLYAHADILVNMNNVIDGYDNERIYSFVPYAGIGIMMTANEPKATKISPNLGVLNTFVLTENLHFTADVRGNFVGDSFDGEVGGRRGEGTLTVSLGVSYTFKKRTFYNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSG1</accession>
    <name>D7VSG1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor</fullName>
            <ecNumber evidence="4">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpoE3</name>
        <name evidence="4" type="ORF">HMPREF0766_13915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13915"/>
    <dbReference type="EnsemblBacteria" id="EFK56712">
        <property type="protein sequence ID" value="EFK56712"/>
        <property type="gene ID" value="HMPREF0766_13915"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_4_1_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="34"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="131"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="185" mass="21908" checksum="50F0FD2A6EACDE99" modified="2010-10-05" version="1">MEVDMAAFENWDDHRLMTELKTNSELAFNVIYFRYSIILYRYAFNILRDEDECTDVVQEIFVWLWENRENLHISNLKSYLMAAVRYRMIRVIATSKRKEEILARSISGTALHADDFLEVKELKNFITDFTASLPLRARATFQLSREQYLSNREIALELGVSEKTVEAQMTISLKKLRLYLNRMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSU1</accession>
    <name>D7VSU1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995803.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14045"/>
    <dbReference type="EnsemblBacteria" id="EFK56842">
        <property type="protein sequence ID" value="EFK56842"/>
        <property type="gene ID" value="HMPREF0766_14045"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033S75">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1165232_0_0_10"/>
    <dbReference type="OrthoDB" id="2053373at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107345" evidence="1">
        <location>
            <begin position="21"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="238" mass="25924" checksum="20F81BFDE28F3E6D" modified="2010-10-05" version="1">MKGHIIFLLTIIFCAPVASFAQLDCPPVIGGAKKANDKFHITAGAGPTVLYGDLPKSGMSVAFFLKADYRIYKGILVGLEGQIGSLKAAATIDTLNKRKVNNGYYAGFVNVTVFPFQFSDKRLSAYSSPTEILLNSFYLGVGFGGIQSEFKELIEADGTVSNNQGKTTNTFLFPVANAGLAIPVNKYNFNNRTGRYFSVVFNAQFSMGQNDALDGFVPVQSQHNDMYTFYSAGVRYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSX9</accession>
    <name>D7VSX9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">META domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995874.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14083"/>
    <dbReference type="EnsemblBacteria" id="EFK56880">
        <property type="protein sequence ID" value="EFK56880"/>
        <property type="gene ID" value="HMPREF0766_14083"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058026_2_0_10"/>
    <dbReference type="OrthoDB" id="2029962at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005184">
        <property type="entry name" value="DUF306_Meta_HslJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038670">
        <property type="entry name" value="HslJ-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03724">
        <property type="entry name" value="META"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="META" evidence="1">
        <location>
            <begin position="39"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="META" evidence="1">
        <location>
            <begin position="162"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="269" mass="29224" checksum="8C693695D777E0C5" modified="2010-10-05" version="1">MKSTIVMSIIAISMSLSSCGVFQKGGKKMDKTETSSSEVITGKKWKLIELNGKPVADKVNGKEPFLELDASEKRYSASGGCNGIGGNFTLSANNRISFAQGMSTMMACPDMTIEQGLSRVFTTVDNYTVKDGILSLNKARMAPLAKFQEVKEGSSSKEQALNGTWELDYISGPRIAFDGLYPNKKPTITFDTANKKANGNSSCNNYNTSIKIEGGNLHFGPVASTKMACQGSGESVYFKTLETITNYDIQDNTLHLIMGDIAVMRFHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSY3</accession>
    <name>D7VSY3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995879.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14087"/>
    <dbReference type="EnsemblBacteria" id="EFK56884">
        <property type="protein sequence ID" value="EFK56884"/>
        <property type="gene ID" value="HMPREF0766_14087"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_378855_0_0_10"/>
    <dbReference type="OrthoDB" id="38808at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107352" evidence="1">
        <location>
            <begin position="23"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="738" mass="84035" checksum="73135B97B65D3EE0" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTC9</accession>
    <name>D7VTC9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase family M3</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dcp</name>
        <name evidence="9" type="ORF">HMPREF0766_14233</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996254.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14233"/>
    <dbReference type="EnsemblBacteria" id="EFK57030">
        <property type="protein sequence ID" value="EFK57030"/>
        <property type="gene ID" value="HMPREF0766_14233"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0339">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001805_4_1_10"/>
    <dbReference type="OrthoDB" id="1935578at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06456">
        <property type="entry name" value="M3A_DCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034005">
        <property type="entry name" value="M3A_DCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43660">
        <property type="entry name" value="PTHR43660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3" evidence="8">
        <location>
            <begin position="226"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK57030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="675" mass="77501" checksum="A3996D43FC68A9C0" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTE8</accession>
    <name>D7VTE8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14252"/>
    <dbReference type="EnsemblBacteria" id="EFK57049">
        <property type="protein sequence ID" value="EFK57049"/>
        <property type="gene ID" value="HMPREF0766_14252"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2939435_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="69" mass="8404" checksum="4FF44EC04F0D5A91" modified="2010-10-05" version="1">MYINNLKKQSDHMKVFVYILIFFLVYFAVSYVLSYFWYAHIDVKWILISSFLSSALMLVFLLVDRRRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTH0</accession>
    <name>D7VTH0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase</fullName>
            <ecNumber evidence="3">3.5.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.6" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996360.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14274"/>
    <dbReference type="EnsemblBacteria" id="EFK57071">
        <property type="protein sequence ID" value="EFK57071"/>
        <property type="gene ID" value="HMPREF0766_14274"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_0_4_10"/>
    <dbReference type="OrthoDB" id="537440at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107572" evidence="1">
        <location>
            <begin position="21"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="44"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="440" mass="48935" checksum="277046E1EC38368B" modified="2010-10-05" version="1">MLKKSVTYLAVFFVASLASAQKIDTEKLDLYIQTLEDNNKFMGSIAISQNGERVYAKSVGYIDLENKIKANENSKYRIGSISKTFTTVLVLKAAEDKKLSLDQTIKQYFPAIKNADKITVGHLLNHRSGIHNFTDDADYLNWNTKVMSEKDMVDVITKAGSDFEPDSKGEYSNSNFVLLTYILEKTLKKSYADLLTANITKPLGLQNTYLGGKINVKNNEAKSYDFAGDWKPESETDISIPLGAGGIVSTPSDLTKFAEALFNGKLLTKASVELMKTIKDNYGMGLFQVPFYDKKGYGHNGGIDGFSSTFSYFEDGNVAFALTSNGTDFNNNNIAIAALRAFYNKPFDIPDFRTYENSSEDLDIYLGSYASTQIPIKITVTKDNKTLVAQASGQPSFSLEATEKHKFKFDQAGIVMEFNPDNKSFVLKQRGGEFLFTKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTM6</accession>
    <name>D7VTM6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001641.1">
        <property type="nucleotide sequence ID" value="NZ_GL379777.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK55785">
        <property type="protein sequence ID" value="EFK55785"/>
        <property type="gene ID" value="HMPREF0766_14346"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2556547_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="82" mass="9771" checksum="8A9E661E6A893155" modified="2010-10-05" version="1">MQEITRDQIKSKIEELKEDFIKLNPKMKGLSSDEIYNSYLYENQLEVPLSGDGESAGWWIKSRIEMEELQPEKFKKFLNKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTN3</accession>
    <name>D7VTN3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tricorn protease homolog</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HMPREF0766_14353</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades oligopeptides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S41B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001663.1">
        <property type="nucleotide sequence ID" value="NZ_GL379777.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14353"/>
    <dbReference type="EnsemblBacteria" id="EFK55792">
        <property type="protein sequence ID" value="EFK55792"/>
        <property type="gene ID" value="HMPREF0766_14353"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4946">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005503_0_0_10"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028204">
        <property type="entry name" value="Tricorn_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012393">
        <property type="entry name" value="Tricorn_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43253">
        <property type="entry name" value="PTHR43253"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14684">
        <property type="entry name" value="Tricorn_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036421">
        <property type="entry name" value="Tricorn_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107671" description="Tricorn protease homolog" evidence="11">
        <location>
            <begin position="22"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="12">
        <location>
            <begin position="779"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="746"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="963"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="1019"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer; via amide nitrogen" evidence="9">
        <location>
            <position position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036421-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036421-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFK55792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1056" mass="119469" checksum="93FD2241E62492AD" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTP0</accession>
    <name>D7VTP0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-dependent receptor plug domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001685.1">
        <property type="nucleotide sequence ID" value="NZ_GL379777.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14360"/>
    <dbReference type="EnsemblBacteria" id="EFK55799">
        <property type="protein sequence ID" value="EFK55799"/>
        <property type="gene ID" value="HMPREF0766_14360"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020298_0_0_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107672" evidence="1">
        <location>
            <begin position="17"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="132"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK55799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="714" mass="80567" checksum="4522F96E00EBBDB4" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTS5</accession>
    <name>D7VTS5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative virulence factor Mce family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_14395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002206.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14395"/>
    <dbReference type="EnsemblBacteria" id="EFK55704">
        <property type="protein sequence ID" value="EFK55704"/>
        <property type="gene ID" value="HMPREF0766_14395"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054524_0_0_10"/>
    <dbReference type="OrthoDB" id="807474at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="40"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK55704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="337" mass="35982" checksum="B8C50709729EB991" modified="2010-10-05" version="1">MSAAENKRTLVVGLFVLIGLIILIAGILTLGGQQKKFTKTLTVTTEFEDVKGLKVGNNVWFSGVKVGIVKDISFESIKYVKVVMSIEAKSSEFIRKDAVAKLGSDGLIGNSIITLVGGSQTAQPIEDGDILHSAKGTDMEAMMATLSVNNDNLVEITRNFAVLSQNLVDGKGMVGAMLTDSSMVVSLSKSLDNLNKLMTNANQASNNLVAVTNKLNNNQGLIHQLSTDTAVFASLRESAAQLQGVTQTASALMSNLNATSARLNDKNNVVGALTNDPEGAAEIKQILRNLNLSTAKLDQNMEAMQSNFLLRGFFKKQQKEKEKAKADSLKALSGSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTW7</accession>
    <name>D7VTW7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002283.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14437"/>
    <dbReference type="EnsemblBacteria" id="EFK55746">
        <property type="protein sequence ID" value="EFK55746"/>
        <property type="gene ID" value="HMPREF0766_14437"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0759">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144811_5_3_10"/>
    <dbReference type="OrthoDB" id="1912220at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00386">
        <property type="entry name" value="UPF0161_YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="84" mass="9719" checksum="34FFF6B88C638135" modified="2010-10-05" version="1">MKAIIFIWEKIIKGALRFFFILLIRFYQLFISPLLGANCRYTPTCSQYGMEAIKKYGPFKGGWLAIKRILRCNPWGGHGHDPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGD3</accession>
    <name>D7VGD3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001947.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10052"/>
    <dbReference type="EnsemblBacteria" id="EFK60108">
        <property type="protein sequence ID" value="EFK60108"/>
        <property type="gene ID" value="HMPREF0766_10052"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50333WX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1667055_0_0_10"/>
    <dbReference type="OrthoDB" id="1381684at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="167" mass="19632" checksum="1248B8B827AAEF2A" modified="2010-10-05" version="1">MMLRISKSTLTKVNYVLIISLLMVALTGVLFSRSPEKLIQGEWEEVGWYFEKSDYNNKTSSQSGYINEQMKLEIFDQVVPYHMNVWHFAENGSILSEQDTDSLQWYIKGRGHILELRKDGRKIESFQIQNLTRDKMELHFNLDLQVKGVVKIVLKRKELENNYAKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGH7</accession>
    <name>D7VGH7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002049.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10096"/>
    <dbReference type="EnsemblBacteria" id="EFK60152">
        <property type="protein sequence ID" value="EFK60152"/>
        <property type="gene ID" value="HMPREF0766_10096"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7WP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090961_0_0_10"/>
    <dbReference type="OrthoDB" id="1850729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="272" mass="31369" checksum="3BFEBBEDAE26C8F9" modified="2010-10-05" version="1">MNYIRHLTAFFEKVAPDQVLNPTHISLYIALFQFWNFNRFRNPISISRDEIMRISKISSKATYHKCLKNLHALGYINYQPSYNPFKGSQVYMLNFSDELKPVSRSRSNTEPPGRQATDNHCTTSQTSTEQALIPSVNSINNTNPLNNENGYTQASDPEQEIQPDQQHHPPDTSKEKKLRAKKKGFTPPELSELKEYFRTKDYPEVEADKFYNYFSSNGWLVGGKTPMKDWQAAARNWILNTPKYNNHGYTTPTSDRTRNLSTTTGKNYAEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGN7</accession>
    <name>D7VGN7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTTP/UTP pyrophosphatase</fullName>
            <shortName evidence="2">dTTPase/UTPase</shortName>
            <ecNumber evidence="2">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="2">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">maf</name>
        <name evidence="3" type="ORF">HMPREF0766_10156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + UTP = diphosphate + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:29395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTTP + H2O = diphosphate + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28534"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Maf family. YhdE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996748.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10156"/>
    <dbReference type="EnsemblBacteria" id="EFK59239">
        <property type="protein sequence ID" value="EFK59239"/>
        <property type="gene ID" value="HMPREF0766_10156"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0424">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040416_0_0_10"/>
    <dbReference type="OrthoDB" id="1469203at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036221">
        <property type="term" value="F:UTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="193" mass="21683" checksum="06EE494DA0C94B4A" modified="2010-10-05" version="1">MLDNLKNIPVILGSQSPRRKELLAGMGVDFDVVVKETDESFDPDLLPEQIVASIAEKKAAAFNNAEYEDHLLITADTIVVAHNTILGKPQDRDDAFRMLSMLSDDTHQVMTAVSVLWKGELRTFVECTDVVFPELSTDEINYYLEHYKPYDKAGAYGIQEWMGIVAIDQIKGSYTNVVGLPTARLYQELKNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGS1</accession>
    <name>D7VGS1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, LacI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_10190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996823.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10190"/>
    <dbReference type="EnsemblBacteria" id="EFK59273">
        <property type="protein sequence ID" value="EFK59273"/>
        <property type="gene ID" value="HMPREF0766_10190"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_0_10"/>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="40"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="368" mass="42115" checksum="69369433676A27DB" modified="2010-10-05" version="1">MQMACISFRRDGQNKCKCLKDFLLCKVGLIQIAMKKEKPATIKEIARKLKISPSTVSRALNDHPSIGLVTTMRVKKMAEEMNYEPNQTAIFFKQRKTFTIGVVLPSLSEPFFSAAISEIENFANERKYTVIMGQSMDDAERELRILQTLKKHRVDGVLMSIGKNTNSFDFIKSMEESEIPVVFFDCVPNLNDIDRIECDLATGVYEAIDAFVSRGHQKIALINGPDTLLASEERKLAYIKGLRKNDIAFDDRYLVNTDLTEEGNEEAMNKLLTLSDRPSAILSFNDFVTLDVMKFARQRGVSLNSDIHFISFANYPLWKYMENPPMGSIEQFPDQQAKKAAEILFNRLENKEEYKPQQFIFKSRLILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGT4</accession>
    <name>D7VGT4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996859.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10203"/>
    <dbReference type="EnsemblBacteria" id="EFK59286">
        <property type="protein sequence ID" value="EFK59286"/>
        <property type="gene ID" value="HMPREF0766_10203"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_528700_0_0_10"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107174" description="Thioredoxin domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="361"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="510" mass="58663" checksum="0370BD992A2C9BC4" modified="2010-10-05" version="1">MKGLHLIVNGLLVLISHFAYAQDAFIALTDIKFDDRYDEGRQNPVIKGTILNATENELKQLAVSLTLVRPNEPTQVNNSIRIAADGSFTYILPSVLPYQQIWFSLGDYVYSCLYINEGLNLTFDLERLKKQKVYMLGEGMEFSGKDGEINRVLNTYILYNKKHLPDFYENLYNLKVEDLRFMEKTDSLFMLKRKIDSQFLVENRNIAQHIIESETENQFLSTKIKYLLFHKMEITDITELLAPVYAVTNESGEYLRYLYWYTNNLKLHSKEERRNREILFFKIDSIFPPAFADLVKLQVSSEDVAEQLSINKDMVTGLKTDWAKRYVTEEIIILKTKSAKIQGLLTGTRDNAGASKIGKYLKSTDFNASMYLNEAKTGEELLKSIQASFPDKLIILNLWATWCAPCIQNMPHSKNVQQQVAKENLPVTFVYLCTDGGSSESVWQNKIAELEQPGEHIFVQNEQMNELLTLFNGKGYPTYAVIKPNGQIDTKTINLNRSFDIHVLQKLLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH56</accession>
    <name>D7VH56_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine biosynthesis bifunctional protein HisB</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Histidinol-phosphatase</fullName>
                <ecNumber evidence="8">3.1.3.15</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">Imidazoleglycerol-phosphate dehydratase</fullName>
                <shortName evidence="8">IGPD</shortName>
                <ecNumber evidence="8">4.2.1.19</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">hisB</name>
        <name evidence="9" type="ORF">HMPREF0766_10325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the histidinol-phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="8"/>
    <dbReference type="EC" id="4.2.1.19" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997172.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10325"/>
    <dbReference type="EnsemblBacteria" id="EFK59408">
        <property type="protein sequence ID" value="EFK59408"/>
        <property type="gene ID" value="HMPREF0766_10325"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0241">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044308_0_0_10"/>
    <dbReference type="OrthoDB" id="1278103at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01022">
        <property type="entry name" value="Bifunc_HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020566">
        <property type="entry name" value="His_synth_bifunc_HisB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005954">
        <property type="entry name" value="HisB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006543">
        <property type="entry name" value="Histidinol-phos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01261">
        <property type="entry name" value="hisB_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01656">
        <property type="entry name" value="Histidinol-ppas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Histidinol-phosphatase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Imidazoleglycerol-phosphate dehydratase" evidence="8">
        <location>
            <begin position="189"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="379" mass="42990" checksum="79E99A5177541F81" modified="2010-10-05" version="1">MPNHIKRVLFIDRDGTLILEPEDEQIDSFAKLKFYPGALQYLPRIAKELDYELVLVTNQDGLGTDSHPEANFWPVHQLVTDTFAGEGVVFAKEHIDRTFPHENAATRKPGIGMLLDYFDPEKYDLQHSFVIGDRVNDVKLAQNLGAKAIWLRANDNLGVAENLQIEESVVALETKDWKAIYEFLKLGSRTGEHHRKTNETDIYIHLNLDGSGKSDIDTGLPFFDHMLDQIARHGAIDLTIKAKGDLHIDEHHTIEDTGIALGEVFLKVLGDKRGIERYSYTLPMDDCLAQVALDFGGRNWIVWDATFNREKIGDMPTEMFFHFFKSFSDASRSNLNIKAEGENEHHKIEAIFKAFAKSIKKAVRRDADNMQLPSTKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH62</accession>
    <name>D7VH62_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAM hydrolase / SAM-dependent halogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997184.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10331"/>
    <dbReference type="EnsemblBacteria" id="EFK59414">
        <property type="protein sequence ID" value="EFK59414"/>
        <property type="gene ID" value="HMPREF0766_10331"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1912">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059734_1_1_10"/>
    <dbReference type="OrthoDB" id="1262717at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002747">
        <property type="entry name" value="SAM_Chlor/Fluor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023227">
        <property type="entry name" value="SAM_OH_AdoTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023228">
        <property type="entry name" value="SAM_OH_AdoTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35092">
        <property type="entry name" value="PTHR35092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01887">
        <property type="entry name" value="SAM_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006779">
        <property type="entry name" value="UCP006779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101852">
        <property type="entry name" value="SSF101852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102522">
        <property type="entry name" value="SSF102522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="261" mass="29426" checksum="F0CB217B347381B0" modified="2010-10-05" version="1">MGVITLTTDLGYQDFYQAALKGSIISQLPDVRIVDITHEIPSFNVQHAAFVLKNAYHYFPKKTVHLIGIDTVFQEDSRYIAMKYNGHFFVGADNGIFSIILGENQAEEVVELDIMQDLRYLHFPLADILTKATCHIAKGGKMSEIGIPIDKPIEKATFQPIFDQNSIKGHVSYIDSFGNVISNISKDLFNKIQAGRGFTLYFKRNETIDKMSWHYNEVSEGEKLCLFGISNFLEIAINKGNASQLLGLSQDEAIRVEFHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH80</accession>
    <name>D7VH80_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prolyl endopeptidase</fullName>
            <ecNumber evidence="5">3.4.21.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">f1pep</name>
        <name evidence="5" type="ORF">HMPREF0766_10349</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.26" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997223.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK59432">
        <property type="protein sequence ID" value="EFK59432"/>
        <property type="gene ID" value="HMPREF0766_10349"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011290_1_1_10"/>
    <dbReference type="OrthoDB" id="315644at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9_N" evidence="4">
        <location>
            <begin position="35"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="493"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="712" mass="78756" checksum="279CA7F302172295" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHC5</accession>
    <name>D7VHC5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997320.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10394"/>
    <dbReference type="EnsemblBacteria" id="EFK59477">
        <property type="protein sequence ID" value="EFK59477"/>
        <property type="gene ID" value="HMPREF0766_10394"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091017_0_0_10"/>
    <dbReference type="OrthoDB" id="1390922at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="238" mass="27474" checksum="6267C57A94F8F2E2" modified="2010-10-05" version="1">MTISDFLIIPAKPEHTHYAEIICDEMFESAKARGTGIARRKPEYVANKMTEGKAVIALHRDGRWAGFCYIETWSHGDYVANSGLIVNPEFRKVGLAKAIKKRVFELSREKYPHAKIFGLTTGLAVMKINSDLGYEPVTYSELTTDDEFWKGCQSCVNYDILVSKERKNCMCTAMLWDPVEKERELKEKIQRKMEAKERLDRIAKKQSLLKRIEAKLWKSTKKMVMAVFPYHRKPAKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHE8</accession>
    <name>D7VHE8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fabG7</name>
        <name evidence="2" type="ORF">HMPREF0766_10417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997390.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10417"/>
    <dbReference type="EnsemblBacteria" id="EFK59500">
        <property type="protein sequence ID" value="EFK59500"/>
        <property type="gene ID" value="HMPREF0766_10417"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_10"/>
    <dbReference type="OrthoDB" id="1582456at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="236" mass="25345" checksum="85953D62003C5DE5" modified="2010-10-05" version="1">MANIVITGASSGIGFEAVLDLTANKENNVIALARSADKLRKLHEIASSLNYDGGKLYPAQFDIVYDNYPEILVPFIQSKFDSVDILINNAGALVYKPFLETSAEDFATMLQTNVLGHVNMIRHVAPLMKNGGHIVNISSMGGFQGSVKFPGLSAYSASKGALGVLTECLAEEFKEQGIKVNCLALGSSQTEMFETAFPGVEAGTLAFEMGRYIAEFAQNGSKYYNGKILPVSNTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHG6</accession>
    <name>D7VHG6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit alpha</fullName>
            <shortName evidence="11">RNAP subunit alpha</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">RNA polymerase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Transcriptase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">rpoA</name>
        <name evidence="13" type="ORF">HMPREF0766_10435</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997443.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10435"/>
    <dbReference type="EnsemblBacteria" id="EFK59518">
        <property type="protein sequence ID" value="EFK59518"/>
        <property type="gene ID" value="HMPREF0766_10435"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053084_0_1_10"/>
    <dbReference type="OrthoDB" id="662686at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00059">
        <property type="entry name" value="RNApol_bact_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02027">
        <property type="entry name" value="rpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLD" evidence="12">
        <location>
            <begin position="21"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha N-terminal domain (alpha-NTD)" evidence="11">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha C-terminal domain (alpha-CTD)" evidence="11">
        <location>
            <begin position="253"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFK59518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="330" mass="37140" checksum="057B888F0B1B7A87" modified="2010-10-05" version="1">MAILAFQRPDKVIMQKSTDFDGTFEFRPLEPGFGVTIGNALRRILLSSLEGYAITSIRFSGVSHEFSTIKGVVEDVTEIILNLKQIRFKKTGEQGDSEKIFVVINGQEQFLAGDITKFSNNFTVLNPDFVVCNMDSSVTIEVELSVAKGRGYVNAEENKVTDGPVGLIAIDSIFTPIKNVKYTIENYRVEQKTDYEKLLLDITTDGSIHPEDALKEAAKILIQHFMLFSDENMLLESQTKEETKVVDEEILHMRKILKTELVDLDLSVRALNCLKAADIRTLAELVTYDVADMLKFRNFGKKSLSEIQELVKSKGLSFGMNLSKFKLDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHM1</accession>
    <name>D7VHM1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13 15">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="6 13 15">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">trmD</name>
        <name evidence="17" type="ORF">HMPREF0766_10490</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13 15">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 15">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13 15">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="6 13 15"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997555.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10490"/>
    <dbReference type="EnsemblBacteria" id="EFK59573">
        <property type="protein sequence ID" value="EFK59573"/>
        <property type="gene ID" value="HMPREF0766_10490"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047363_0_1_10"/>
    <dbReference type="OrthoDB" id="525632at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 13 15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_m1G_MT" evidence="16">
        <location>
            <begin position="23"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="13 14">
        <location>
            <begin position="132"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFK59573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="225" mass="25299" checksum="A34D86C9A041F397" modified="2010-10-05" version="1">MRFDIITVLPDLLTSPFAHSILQRAQKKGLAEIVVHNLRDYATNKQKSVDDYPYGGGSGMVMQIEPFAKCIEYLQSERDYDEIIFMSPDGQTLNQEIANTLSTKGNMMILCGHYKGIDQRIRDIYVTKEISIGDYVLSGGELPAAILTDAIIRLIPGVLSDETSALSDSFQDGLLDAPIYTRPAEWRGHKVPDILLSGNEAKILAWRDEQQLQRTKERRPDLLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHP6</accession>
    <name>D7VHP6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MazG nucleotide pyrophosphohydrolase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ypjD</name>
        <name evidence="2" type="ORF">HMPREF0766_10515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997605.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10515"/>
    <dbReference type="EnsemblBacteria" id="EFK59598">
        <property type="protein sequence ID" value="EFK59598"/>
        <property type="gene ID" value="HMPREF0766_10515"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1694">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142229_0_0_10"/>
    <dbReference type="OrthoDB" id="1760741at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11531">
        <property type="entry name" value="NTP-PPase_BsYpjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012359">
        <property type="entry name" value="MazG-related_YpjD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42692:SF1">
        <property type="entry name" value="PTHR42692:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029904">
        <property type="entry name" value="UCP029904_pph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="108" mass="12443" checksum="7E19E8411CD1476D" modified="2010-10-05" version="1">MTIKEAQETIDQWINTTGIRYFNELTNTAMLMEEVGEVARIMARQYGEQSFKKSDKEVNLADEMADVLFVLMCLANQTGIDLTDALEKNLEKKSIRDADRHKNNEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHW6</accession>
    <name>D7VHW6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein</fullName>
            <ecNumber evidence="6">2.7.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_10585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.-" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997803.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10585"/>
    <dbReference type="EnsemblBacteria" id="EFK59668">
        <property type="protein sequence ID" value="EFK59668"/>
        <property type="gene ID" value="HMPREF0766_10585"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_75_10"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="223"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="466"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK59668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="586" mass="67032" checksum="F3A6B58391730C6F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHY6</accession>
    <name>D7VHY6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arylsulfatase</fullName>
            <ecNumber evidence="7">3.1.6.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">arsa</name>
        <name evidence="7" type="ORF">HMPREF0766_10605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.-" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997841.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10605"/>
    <dbReference type="EnsemblBacteria" id="EFK59688">
        <property type="protein sequence ID" value="EFK59688"/>
        <property type="gene ID" value="HMPREF0766_10605"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_10_3_10"/>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032158">
        <property type="entry name" value="DUF4994"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16385">
        <property type="entry name" value="DUF4994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005672210" evidence="4">
        <location>
            <begin position="25"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="5">
        <location>
            <begin position="30"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4994" evidence="6">
        <location>
            <begin position="407"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="505" mass="55576" checksum="D17957ABFE40ABD7" modified="2010-10-05" version="1">MNVKHICCYISLAVFLFAGQQVQAQNKQKPNVLMIYVDDLGYGDLSIYGGQDIETPHLDELATSGIRFTNAHAAASTCTPSRYALMTGNNPYRAKGTGILPGDAALIIPQDKITLPKVFHQQGYTTGIVGKWHLGLGEQVEKDWNGKIAPGPLEVGYDYSFIFPATADRVPTVFLENHYVLAADAKDPIKVNYRQKIGNEPTGKENPELLKLYASPGQGHDNTIVNGIGRIGWMTGGKDARWADEELTLTFFEKAKEFIKTNHKKPFFLCYNATEPHVPRMPATLFKGKSKLGLRGDAILQLDYTVGQLVQELKNNGIYENTIIIFTSDNGPVLDDGYADQAVEKSANHDAFGGWRGGKYSAFEAGSRVPFLVSWPAVIKGGQQSDALIGQVDLLASFAGQLGVSYPKDQAVDSQNQWKALTGADKKGRTYLVKSSGTFSIIQGDYKYIKPRKGAKIDKAVNIELGNDEQPQLYNLRTDKAEKENIAAKHTNKVKELEQLLQSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI01</accession>
    <name>D7VI01_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997872.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10620"/>
    <dbReference type="EnsemblBacteria" id="EFK59703">
        <property type="protein sequence ID" value="EFK59703"/>
        <property type="gene ID" value="HMPREF0766_10620"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1081444_0_0_10"/>
    <dbReference type="OrthoDB" id="1469741at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="47"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="257" mass="29360" checksum="4B935E4A5532AF02" modified="2010-10-05" version="1">MLIGTNQIEIMKLKNIFFPAIIFIIIGLSACKKEYYEETGKHDPKYNGTIWQYLQGRKDLFDTLTKVVEYAGMKDILDKESVTFFAPPDMSIVKAMKELNEYLVSRGQDTVTSYKQVDPSVWKDFLGMYIIKDKYVLKDFPQLDTINLETFGGQGYTSYSGRVMNIGVLYNDTKTVNSNGDIQIIKYSGYRQLYLNYVENYSSSNNLFSMTTGPVATSDIQPTNGVLHVLQFSRHIFGFQRLDFVRAAVDKGIKPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI45</accession>
    <name>D7VI45_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997960.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10664"/>
    <dbReference type="EnsemblBacteria" id="EFK59747">
        <property type="protein sequence ID" value="EFK59747"/>
        <property type="gene ID" value="HMPREF0766_10664"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082049_1_1_10"/>
    <dbReference type="OrthoDB" id="1739979at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025665">
        <property type="entry name" value="OMP_b-brl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13568">
        <property type="entry name" value="OMP_b-brl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107513" description="OMP_b-brl_2 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl_2" evidence="2">
        <location>
            <begin position="22"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="210" mass="23065" checksum="41BECAE38F4D3A2F" modified="2010-10-05" version="1">MKRLSIVLAFVCMSVAVHAQYKSKIEFGVKGGLAFPTFQFSEGGNPRTYLSGFVGGFVDLPVAQYFSIQPGVSLVGKGYNDKFFESETSYGNLKTRLWVVEIPLHIVGKMLIGNDQLQFGAGPYIGFNLSGKQKFEGQSDVYKSGNIDFDFNGKEMKRQDYGISLMANYKFENGLLVNMGYGLGLSNLYGSNIDNTAKNRVLSLGVGIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI78</accession>
    <name>D7VI78_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, group 1 family protein</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998025.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10697"/>
    <dbReference type="EnsemblBacteria" id="EFK59780">
        <property type="protein sequence ID" value="EFK59780"/>
        <property type="gene ID" value="HMPREF0766_10697"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_3_10"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="178"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="358" mass="41241" checksum="27A6AAA2895D8F68" modified="2010-10-05" version="1">MKVLFIINDLNSGGIENYLLRFLKYYNKKLIPVVLCKSGNKGALENEYLKIEDIEIVPLRIGFLDFKGISSFRNFMKNNNFDSVVDFTGNFAGLTMFISYRVGIKKRITFYRGATNHFKENAIRLFYNFLVNKLVLRFSTDILSNSKAAFNYFFKNNIDNRFEVIYNGIDADQFLNCKDDIREELGIPKDGFVVGHVGRLAREKNHETIWEVAKILCSQHKNIYFILCGKGVDDTYSEMIKELKLTDQIIVLGYRRDVVKVLNSMNVFYFPSLSEGQPNALIEALIAGLPFVASNIEPIKETIPEEYQKSLVNPLDINNAVSKIEDIYINGVQGDNLKKWAITKYNPEVLFLQFFKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI88</accession>
    <name>D7VI88_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S23 ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10707"/>
    <dbReference type="EnsemblBacteria" id="EFK59790">
        <property type="protein sequence ID" value="EFK59790"/>
        <property type="gene ID" value="HMPREF0766_10707"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129874_0_6_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="91" mass="10506" checksum="A029A73BABF376D5" modified="2010-10-05" version="1">MILVEDIYRIAANFPKEEMFGLTSQIKRSVVSIPSNIAEDAGRRGKVEFIRFLYIALGSTNELETQLEISVRLGFMQKNKDIFKQIHFIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIK4</accession>
    <name>D7VIK4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arylsulfotransferase (ASST)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998269.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10823"/>
    <dbReference type="EnsemblBacteria" id="EFK59906">
        <property type="protein sequence ID" value="EFK59906"/>
        <property type="gene ID" value="HMPREF0766_10823"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZAQ1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026701_0_0_10"/>
    <dbReference type="OrthoDB" id="272464at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004062">
        <property type="term" value="F:aryl sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035391">
        <property type="entry name" value="Arylsulfotran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010262">
        <property type="entry name" value="Arylsulfotransferase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038477">
        <property type="entry name" value="ASST_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17425">
        <property type="entry name" value="Arylsulfotran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05935">
        <property type="entry name" value="Arylsulfotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107271" evidence="1">
        <location>
            <begin position="27"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Arylsulfotran_N" evidence="2">
        <location>
            <begin position="117"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="605" mass="67766" checksum="074A30521F75F2D5" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIY3</accession>
    <name>D7VIY3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anhydro-N-acetylmuramic acid kinase</fullName>
            <ecNumber evidence="1">2.7.1.170</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">AnhMurNAc kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">anmK</name>
        <name evidence="2" type="ORF">HMPREF0766_10952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O = ADP + H(+) + N-acetyl-D-muramate 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:24952"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58690"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.170"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan recycling.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anhydro-N-acetylmuramic acid kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.170" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998539.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10952"/>
    <dbReference type="EnsemblBacteria" id="EFK60035">
        <property type="protein sequence ID" value="EFK60035"/>
        <property type="gene ID" value="HMPREF0766_10952"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038782_0_0_10"/>
    <dbReference type="OrthoDB" id="736294at2"/>
    <dbReference type="UniPathway" id="UPA00343"/>
    <dbReference type="UniPathway" id="UPA00544"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097175">
        <property type="term" value="P:1,6-anhydro-N-acetyl-beta-muramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006040">
        <property type="term" value="P:amino sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01270">
        <property type="entry name" value="AnhMurNAc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005338">
        <property type="entry name" value="Anhydro_N_Ac-Mur_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605">
        <property type="entry name" value="PTHR30605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03702">
        <property type="entry name" value="AnmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="398" mass="43778" checksum="7B9AFDE02E70EE34" modified="2010-10-05" version="1">MNAQIEKLYALAQKQERMIIGLMSGTSLDGLDIALCKISGSGNNTRLELVDFETMDYEPQFRTYVREVFSKRTIDLQTLSGVNAYVGIVHAKLINQALQQWQMDASQVDIIASHGQTVYHAPQSLTHDTHLPNSTLQVGDGDHIAVITGIITLSDFRQKHIAAGGEGAPLAAYGDFLLFTDKIENRILLNIGGISNFTFLPHKDSPYEAYATDLGPGNTMMNQYMKEHFDEEMDRDAHVARSGKPDQKLLAELSKEPFLLLDFPKTTGPELFNLQYLQHLQELSGTTALSHEDVMATLCHFSADTIVAAILKQCTDLQHVAVYISGGGLHNPLLVELIKDGLPDYKITSFEELGLNPDAKEACLFALLANETLVGKPDHVNQIKDSPAVCMGKISLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ10</accession>
    <name>D7VJ10_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4375 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002092.1">
        <property type="nucleotide sequence ID" value="NZ_GL379779.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10979"/>
    <dbReference type="EnsemblBacteria" id="EFK59145">
        <property type="protein sequence ID" value="EFK59145"/>
        <property type="gene ID" value="HMPREF0766_10979"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107474_0_0_10"/>
    <dbReference type="OrthoDB" id="1520310at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025402">
        <property type="entry name" value="DUF4375"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14300">
        <property type="entry name" value="DUF4375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4375" evidence="1">
        <location>
            <begin position="45"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="168" mass="20093" checksum="D2D2E0D8BFD90413" modified="2010-10-05" version="1">MEFLPIIEKDKFEGQSDKDWDFIYTILEPYQHAIDEVEDENVILDQLCDDQHTLLIYDALYGQVTNGGFLQLIHNGYGPFVFDPVFIEDLERWSLNATAELLKEANVIYLNHKDYLEEERDLREFSALCKHFKEFEPFDDLFYEMMEDEVSRFRKYIEDHIAEFAKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ48</accession>
    <name>D7VJ48_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11017</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002171.1">
        <property type="nucleotide sequence ID" value="NZ_GL379779.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11017"/>
    <dbReference type="EnsemblBacteria" id="EFK59183">
        <property type="protein sequence ID" value="EFK59183"/>
        <property type="gene ID" value="HMPREF0766_11017"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067442_4_1_10"/>
    <dbReference type="OrthoDB" id="1490892at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="237" mass="26995" checksum="A4688CFAC9477D5D" modified="2010-10-05" version="1">MHLFYTPEIESHFANFILTEEESKHAIRVLRLANRDQIHLIDGRGGFYRAEIIDAHPKRTTLQIIEIQEAFQKPSYHLHMAVAPTKNIERFEWFLEKATEVGVQEITPVISEHSERKEVKPDRLNKVIVAAMKQSYKAYMPKLNPAMTLTNFLKQQEQVSAQKAIAHCVDSEKQYLSQVFTPQQDYVILIGPEGDFSTEEIGKTISSGFVPISLGEARLRTETAALTSCVEVALLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ53</accession>
    <name>D7VJ53_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11022"/>
    <dbReference type="EnsemblBacteria" id="EFK59188">
        <property type="protein sequence ID" value="EFK59188"/>
        <property type="gene ID" value="HMPREF0766_11022"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3157941_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="48" mass="5597" checksum="012A63AEA243525A" modified="2010-10-05" version="1">MIPVAKEENSDMWKKAAWDYALFSLFNHIFLRGLHTFAVVFHIFAVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ79</accession>
    <name>D7VJ79_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000426.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11048"/>
    <dbReference type="EnsemblBacteria" id="EFK58932">
        <property type="protein sequence ID" value="EFK58932"/>
        <property type="gene ID" value="HMPREF0766_11048"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033007">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_780553_0_0_10"/>
    <dbReference type="OrthoDB" id="929525at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="SPOR" evidence="2">
        <location>
            <begin position="274"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="355" mass="40521" checksum="610379ED289EA35E" modified="2010-10-05" version="1">MNLGKSINHVLKRHTEVKVDGIGVFKRKHTPATFDQSRNAFLPPINYLELDTQADTGYDFVTYVQRQQQVDRNQAESIVQTEVNKIKEELLQSGQAKLDDLGYLVNYGNTYVFKPLDLTGFHFEPIQDVDDKIRSLEKEIIPSQETIPAEVLPPAIPVPEVPVEREQTKPVVQEPVNTIREEFVFEDERRSSNTIWYIISAVIAIGLIGGLYYWDTYYNKPQAPAPVVNQDTLRETTPSTPVKDTVAGLVPLDTTVHELPAKDSVDIHPGEKEPQAGHEYQIVIGSHAGWTMAKEQVDAMHKKGYTQVYIHESKKSKKWKKVVWKSFSTLEEAQKELKHVQETIEPQAFYERIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJA0</accession>
    <name>D7VJA0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11069"/>
    <dbReference type="EnsemblBacteria" id="EFK58953">
        <property type="protein sequence ID" value="EFK58953"/>
        <property type="gene ID" value="HMPREF0766_11069"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1015286_0_0_10"/>
    <dbReference type="OrthoDB" id="2018534at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="289" mass="34102" checksum="97250B56B18A9B63" modified="2010-10-05" version="1">MVPFFVKNIMDWQNMIGNNDLKSANISGKIAWIKELTFQPENENLVLLGFEITHFNDAGNIVRWEVYHSDGRLTKTLTKTYNADQIMVEDTLKQSDGKYFSQNIYGEDGALLEKQYDYGQGISYKEIYDNDGNVIRNFENGIELEVDEAVNEDPYNENWDSKEVIDQSGKKIRTTRYYSFNQLFDITQSTFDQDGKLMDEKVFASDEELEKDNYIKRDTYTYDTFGNLTRKESNNKSYNGGDWITIHINTYHYDSQNNWVEKQEVMNNKITDFKDKLQFVRKREIKYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJD0</accession>
    <name>D7VJD0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP oxidoreductase coenzyme F420-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000581.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11099"/>
    <dbReference type="EnsemblBacteria" id="EFK58983">
        <property type="protein sequence ID" value="EFK58983"/>
        <property type="gene ID" value="HMPREF0766_11099"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5495">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055635_1_1_10"/>
    <dbReference type="OrthoDB" id="1194694at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018931">
        <property type="entry name" value="DUF2520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019665">
        <property type="entry name" value="OxRdtase/DH_put_Rossmann_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037108">
        <property type="entry name" value="TM1727-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10728">
        <property type="entry name" value="DUF2520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10727">
        <property type="entry name" value="Rossmann-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rossmann-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2520" evidence="2">
        <location>
            <begin position="124"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="255" mass="28381" checksum="EAFEF0C846297E6B" modified="2010-10-05" version="1">MKIVLLGSGNVANHFALRFDQLGYQIVQVYSRHKANAQALALRFNAIATDDLNTVDPLADLYVIAVSDEAIPEVAVHLSNDINGIVVHTSGATDLSILQAFMHSGVLYPVQSISKNIETDFTQIPIGVEASSTSTMESLWKIAKALSHRAFECNSKQRMALHVSAVIVNNFSNILYQLSYEMMQDNNLSFELLLPIIQETAKKVQNKPPIDGQTGPAIRNDNITINKHLNFLRENPPLQTIYQQLTLEIAKRRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJD5</accession>
    <name>D7VJD5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase</fullName>
            <ecNumber evidence="3">2.5.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gds</name>
        <name evidence="3" type="ORF">HMPREF0766_11104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.29" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000591.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11104"/>
    <dbReference type="EnsemblBacteria" id="EFK58988">
        <property type="protein sequence ID" value="EFK58988"/>
        <property type="gene ID" value="HMPREF0766_11104"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_1_10"/>
    <dbReference type="OrthoDB" id="1861068at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="325" mass="36568" checksum="1214C03118EE4132" modified="2010-10-05" version="1">MNTTLTLSRYVQEALTAAVFPQEPANMYDPIRYILTLKGKQVRPVLTLMGAQLFGEEDMEKVVPAALAIEYFHNFSLIHDDIMDKAPLRRGQLTVHEKWDDSVAILSGDGLLVKAYEQVAKCPKENLLDLLTTFNKVATEVCEGQQLDMDFESLNQVTEAQYLHMIRLKTSVLLGGALRMGAIIGQASVEQQELIYDFGVNVGIAFQLQDDILDVYGDPETFGKQVGGDIIANKKTFLLIKLLEYASETDLPHIQNLLTADLEQEPDKVELMKQFYAKYDISTLANRKKEYFTTLAFDTLAKINAPSERKAELITLAENLLNRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJF0</accession>
    <name>D7VJF0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000606.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11119"/>
    <dbReference type="EnsemblBacteria" id="EFK59003">
        <property type="protein sequence ID" value="EFK59003"/>
        <property type="gene ID" value="HMPREF0766_11119"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1676732_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="157" mass="17818" checksum="FFAC8292D97E8514" modified="2010-10-05" version="1">MNRLFSLLLPLLFAVFSCKETKDDTNPSFGLIPIDITANKATSIDPELEKLAKGNDFINIDANYFKQNTSLQNPRISSEERKKIKAVAYRLYSNIITNNNKMTLRAKSGAEIGISEEIYTIFLSSIEEANRYTEQHSKDPNYNVPSVSEDYLESLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJG5</accession>
    <name>D7VJG5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000633.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11134"/>
    <dbReference type="EnsemblBacteria" id="EFK59018">
        <property type="protein sequence ID" value="EFK59018"/>
        <property type="gene ID" value="HMPREF0766_11134"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZA2M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048099_0_0_10"/>
    <dbReference type="OrthoDB" id="1183662at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030890">
        <property type="entry name" value="LP_HExxH_w_TonB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15890">
        <property type="entry name" value="Peptidase_Mx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04549">
        <property type="entry name" value="LP_HExxH_w_tonB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="298" mass="33858" checksum="AE40DF8C4DE0B990" modified="2010-10-05" version="1">MKHLKSIFFAFILISLATSCKKEKLDSKSVFTDTQIEQNDLDKYIYKNLTQPYNIQILYKYVDRESDLNYHLVPAPYEGSVRMTKLLIYLGLEPYDKVTGSKQFIRSYFPKLLNYIGTVAVRNNGTVVLGTAESGTKITMYNLINLNATNGNSPSFLNTYYFKTIHHEFQHILNQTKPFPSNFREITGTKYVDDAWNTVYTTTGAAVADGFVSPYASKSGEEDFAELFSFYVTRSQADFDAILNSTGSTAAGRTIVNTKLNVVKNYMKGEWAIDMDVLRQEMLTRFANLSSFDQTTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJH6</accession>
    <name>D7VJH6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_11145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000649.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11145"/>
    <dbReference type="EnsemblBacteria" id="EFK59029">
        <property type="protein sequence ID" value="EFK59029"/>
        <property type="gene ID" value="HMPREF0766_11145"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_1_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107573" evidence="5">
        <location>
            <begin position="28"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="136"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="429"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1041" mass="113862" checksum="F61C8BE13CB3193F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK72</accession>
    <name>D7VK72_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998992.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11391"/>
    <dbReference type="EnsemblBacteria" id="EFK58674">
        <property type="protein sequence ID" value="EFK58674"/>
        <property type="gene ID" value="HMPREF0766_11391"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032VSQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133706_0_0_10"/>
    <dbReference type="OrthoDB" id="2034220at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="166" mass="19426" checksum="5C41B30C3CB5CAB6" modified="2010-10-05" version="1">MSIRDRLRFEHAPYGISLQPNRRIISSLMCYAVAVVISVIVLILFAQQLGEGGRILCLAVIIYFILHGLYDILFRLNVRYIFDRYDRAVYRENSPFGRRKLMMFDEAVIFINADSGSWHYSLGIKRKQFLKNYKISPNYSNGKISEKHSMEFEEEILDPLILLLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK77</accession>
    <name>D7VK77_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_11396</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11396"/>
    <dbReference type="EnsemblBacteria" id="EFK58679">
        <property type="protein sequence ID" value="EFK58679"/>
        <property type="gene ID" value="HMPREF0766_11396"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030646_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="540"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="355"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="431"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="593" mass="69029" checksum="9E2C7A7E4D542495" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKC4</accession>
    <name>D7VKC4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="14">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="14">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 19" type="primary">pheT</name>
        <name evidence="19" type="ORF">HMPREF0766_11443</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="14"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999127.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11443"/>
    <dbReference type="EnsemblBacteria" id="EFK58726">
        <property type="protein sequence ID" value="EFK58726"/>
        <property type="gene ID" value="HMPREF0766_11443"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016891_0_0_10"/>
    <dbReference type="OrthoDB" id="53568at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="43"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="18">
        <location>
            <begin position="410"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="706"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFK58726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="799" mass="88215" checksum="A7FA1640EB63A13E" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKH9</accession>
    <name>D7VKH9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rluD</name>
        <name evidence="5" type="ORF">HMPREF0766_11498</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11498"/>
    <dbReference type="EnsemblBacteria" id="EFK58781">
        <property type="protein sequence ID" value="EFK58781"/>
        <property type="gene ID" value="HMPREF0766_11498"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_4_3_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="31"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="348" mass="39718" checksum="DD15EBD6FC8518A0" modified="2010-10-05" version="1">MMAEDLALQEQDEQELFEHLRIEVDKGQALLRIDKFLMNRVENASRNKIQNAIDAGSVLVNDSVIKSSYKVKPFDIISVVLPDPPRDTEVYPEDIPLDIIFEDDEVMVVNKVAGMVVHPGFNNYTGTLVNALTHHFNQLPTMPGNAGRPGLVHRIDKDTSGLLVIAKSEWAMTYLAKQFFDHSIMRKYVAMVWGDIAEDGTVTGYIGRNLKDRRVMTMYDDSEKGKWSVTHYRVLERLGYVTLIECQLETGRTHQIRAHMQSIGHPLFNDVAYGGDRILKGTVFNKYRQFVENCFALLPRQALHAQVLGFEHPKSKEFLTFETPLPEDFRLALEKWRGYSTTSGQEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKR9</accession>
    <name>D7VKR9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999465.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11588"/>
    <dbReference type="EnsemblBacteria" id="EFK58871">
        <property type="protein sequence ID" value="EFK58871"/>
        <property type="gene ID" value="HMPREF0766_11588"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032XDM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1219079_0_0_10"/>
    <dbReference type="OrthoDB" id="1729274at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="232" mass="26341" checksum="4B9DE7C0FE23827B" modified="2010-10-05" version="1">MKTNIILILCTIGLFAVSCKKDPVIDGGIHQAKVNMTTYDFLKSHSRNMFDTTILIIDKAGLKDLVNSRGTFFVPNDYSIANFLALKQAEVRKKDERLNYTLDSLFKYFTPQMLKDSIGLYFIPERQVNWPDLAQTWSEYKTSVSNLTLWVNVESLDGYNGSGIFSEKPKVVYLNKVVGEKDLLVNGRYEDPTKDPKKLDLRSVCQTSGIETTTGIVHVLANTHIWTFKTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKU0</accession>
    <name>D7VKU0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PDZ/DHR/GLGF domain protein</fullName>
            <ecNumber evidence="2">3.4.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999501.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11609"/>
    <dbReference type="EnsemblBacteria" id="EFK58892">
        <property type="protein sequence ID" value="EFK58892"/>
        <property type="gene ID" value="HMPREF0766_11609"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3975">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022755_0_1_10"/>
    <dbReference type="OrthoDB" id="679125at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024191">
        <property type="entry name" value="Peptidase_M61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007963">
        <property type="entry name" value="Peptidase_M61_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040756">
        <property type="entry name" value="Peptidase_M61_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05299">
        <property type="entry name" value="Peptidase_M61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17899">
        <property type="entry name" value="Peptidase_M61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016493">
        <property type="entry name" value="Glycyl_aminpptds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="459"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="579" mass="66138" checksum="A77619E764E35F86" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL15</accession>
    <name>D7VL15_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase T</fullName>
            <ecNumber evidence="8">3.4.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pepT</name>
        <name evidence="8" type="ORF">HMPREF0766_11684</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999715.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11684"/>
    <dbReference type="EnsemblBacteria" id="EFK58288">
        <property type="protein sequence ID" value="EFK58288"/>
        <property type="gene ID" value="HMPREF0766_11684"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053676_0_0_10"/>
    <dbReference type="OrthoDB" id="1015417at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045148">
        <property type="term" value="F:tripeptide aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010161">
        <property type="entry name" value="Peptidase_M20B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42994:SF1">
        <property type="entry name" value="PTHR42994:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037215">
        <property type="entry name" value="Peptidase_M20B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01882">
        <property type="entry name" value="peptidase-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="M20_dimer" evidence="7">
        <location>
            <begin position="221"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR037215-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037215-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="420" mass="45910" checksum="43B1D3B57DC0A7E2" modified="2010-10-05" version="1">MSTFDINSITDFSVSERFQRYVQIDTQSDAESPSCPSTEKQKNLGNLLVEELLSLGITDAAIDENGYVYATIPSNTDKNVPKICFCSHMDTSPDSSGKDVKPLVHSNYQGQDLVLPDDTTIVIKFDQHPDLANQIGNDVITASGTTLLGADDKAGIAEIMDAARLFMNHPEIKHGDIKILFTPDEEIGRGVDKADLKRLGADFAYTMDGERAGTIEDETFSADGATITIQGVSVHPGFAKGKMQNAVKIAGAIIDALPKDRLSPESTSKKEGFIHPASVSGTVEKAVIHFIVRDHITSNLKKHEDELEAIAESVIAQYPGTTFTIEVKEQYRNMKEVLDQYPQIMEIGMEAIKRGGMTPERRSIRGGTDGSRLSFMGLPCPNIFAGGHAFHGKQEWVSVQDMQKAVITILHIAALWEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLA3</accession>
    <name>D7VLA3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diaminopimelate epimerase</fullName>
            <shortName evidence="3">DAP epimerase</shortName>
            <ecNumber evidence="3">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">dapF</name>
        <name evidence="4" type="ORF">HMPREF0766_11772</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999929.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11772"/>
    <dbReference type="EnsemblBacteria" id="EFK58376">
        <property type="protein sequence ID" value="EFK58376"/>
        <property type="gene ID" value="HMPREF0766_11772"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053306_3_2_10"/>
    <dbReference type="OrthoDB" id="1921631at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="189"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="200"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="3">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="3">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="259" mass="29156" checksum="198583379646B9C0" modified="2010-10-05" version="1">MTDQIKFYKYQGAGNDFILIDNRNGAFERANEAFIKQICDRRFGVGADGLMLLQDTKNFDFEMVYYNADGREGSMCGNGGRCIVAFARDLDIIRQDAAFLAVDGPHQAQIHDNQVNLQMIDVDQITKDETAYVLNTGSPHFIKIVSDLKNMDVYKEGYTIRNNATYKNEGINVNFVEKEENGYFVRTFERGVEDETLACGTGATAAAMAMSIEENMEGQIEIPIRVLGGQLYISFFKKGLTFREVYLKGPAKYVFEGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLD1</accession>
    <name>D7VLD1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor</fullName>
            <ecNumber evidence="4">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpoE9</name>
        <name evidence="4" type="ORF">HMPREF0766_11800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000010.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11800"/>
    <dbReference type="EnsemblBacteria" id="EFK58404">
        <property type="protein sequence ID" value="EFK58404"/>
        <property type="gene ID" value="HMPREF0766_11800"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_4_3_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014327">
        <property type="entry name" value="RNA_pol_sigma70_bacteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02985">
        <property type="entry name" value="Sig70_bacteroi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="113"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="184" mass="22310" checksum="4387EA4C4071F768" modified="2010-10-05" version="1">MLAGIEHIPLQKEHKFEMIFREHFKDLHRYAFRFLEDSAIAEEVVQQVFMRLWERDWETDIHTSLKAYLYRAVYHESLNTLKREQLKRRYQEYQLLHEKDTEYMDQGDSELKKQLHQALLQLPEKSRAVFEMSRFQDLKYKEIADLLNLSIKTVEGHMSKALRHLRVHLVDYLTFLIISLLFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLF8</accession>
    <name>D7VLF8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="8">3.5.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nagA</name>
        <name evidence="8" type="ORF">HMPREF0766_11828</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000085.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11828"/>
    <dbReference type="EnsemblBacteria" id="EFK58431">
        <property type="protein sequence ID" value="EFK58431"/>
        <property type="gene ID" value="HMPREF0766_11828"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032482_2_2_10"/>
    <dbReference type="OrthoDB" id="1026967at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047419">
        <property type="term" value="F:N-acetylgalactosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="PTHR11113:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="7">
        <location>
            <begin position="54"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="218"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="298"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="374" mass="40189" checksum="5E5191FC6625E135" modified="2010-10-05" version="1">MHTKTVIVNGRIFTGTEILSDRIIVLENDKVSSIIPSDQLPAGAKVIDANGGLVSAGLIDLQIYGAGDQLFSAELTSDSLAKIEDTLLKQGCTSYLLCLATNTIGVFKTAIAVVNKYVPRVALGLHLEGPFLNAKKRGAHPEELIIKATAEEITHLLNDDHKALVKMMTVAPELLDADCLSLLLERGILLSAGHSNATFEEATAGFDSGIQTATHLFNAMSAFHHRETGLPGAVFNHQRACASIILDGIHVNYEAAKVAKRQMGERLFMITDAVARCDKGIYKHILNVDHYVLPDGTLSGSALTMLQAVKNAVLQVDIPLEEALRMATLYPANLIGRTDLGRIEAGATANIIVFDDAFGLQQVVFEGELIDIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLJ9</accession>
    <name>D7VLJ9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/isomerase family protein</fullName>
            <ecNumber evidence="2">4.2.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">crt</name>
        <name evidence="2" type="ORF">HMPREF0766_11869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.55" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000182.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11869"/>
    <dbReference type="EnsemblBacteria" id="EFK58472">
        <property type="protein sequence ID" value="EFK58472"/>
        <property type="gene ID" value="HMPREF0766_11869"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_10"/>
    <dbReference type="OrthoDB" id="1498685at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003859">
        <property type="term" value="F:3-hydroxybutyryl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="257" mass="27816" checksum="6FA247963845297D" modified="2010-10-05" version="1">MNTLENLLVKKQSHICYITFSREQQLNALNTKTFEELSTVLDDIAADQDIWGVIVTGAGSKAFIAGADIKEFQSLDEKEGRLLATSGHGVMDRIYNFDKPVIAAINGFALGGGLELALACHMRVAAVSAKLGLPEVSLGLIPGYGGTQRLTDLVGRGKAMEMILSGNMITSEEALSWGMINHVTEVEDLLSKAEEILGHIFSRSKTSVKAAIRAINASISKEENGYEVEVAEFGKCFGQPDFTEGVSAFVEKRKPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLL3</accession>
    <name>D7VLL3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit B</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nuoB2</name>
        <name evidence="1" type="synonym">nuoB</name>
        <name evidence="4" type="ORF">HMPREF0766_11883</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000210.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11883"/>
    <dbReference type="EnsemblBacteria" id="EFK58486">
        <property type="protein sequence ID" value="EFK58486"/>
        <property type="gene ID" value="HMPREF0766_11883"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_7_3_10"/>
    <dbReference type="OrthoDB" id="1904620at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0408">Iron</keyword>
    <keyword evidence="1 2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="3">
        <location>
            <begin position="44"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="184" mass="19833" checksum="34683CB4199CDC12" modified="2010-10-05" version="1">MSNVKLAEAPPGVEGSGFFATTLDKAIGLARANSLWPLPFATSCCGIEFMATMGSTYDLARFGAERPSFSPRQADMLLVMGTIAKKMAPVLKQVYVQMAEPRWVIAVGACASSGGIFDTYSVLQGIDEIIPVDVYVPGCPPRPEAILDGVLRLQEIVKNESLNRRNTPEYKALLEKYGIATDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLR1</accession>
    <name>D7VLR1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane assembly lipoprotein YfiO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yfiO</name>
        <name evidence="2" type="ORF">HMPREF0766_11931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000317.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11931"/>
    <dbReference type="EnsemblBacteria" id="EFK58534">
        <property type="protein sequence ID" value="EFK58534"/>
        <property type="gene ID" value="HMPREF0766_11931"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068039_0_0_10"/>
    <dbReference type="OrthoDB" id="1256747at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017689">
        <property type="entry name" value="BamD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039565">
        <property type="entry name" value="BamD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13525">
        <property type="entry name" value="YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03302">
        <property type="entry name" value="OM_YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YfiO" evidence="1">
        <location>
            <begin position="40"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="304" mass="36110" checksum="ACCF49B61DB84AA8" modified="2010-10-05" version="1">MFLNRRLVAVVAGLLLIVFISGCKSKFEKLRASNNLALKYQEAVKFYEKKKYTKALALFDDLMQRYRGQAEAEDLYYYTAYTNYRLKDYTSARYHFKQFAQTFPNSAKAEECRFMTAYCFYLDSPRSSLDQENTRKAIDELQLFVNLYPESEKAKEAADLIQQLRDKLEKKAFSNAKLYYDMGLNDDYKAAVIALENVLKEYPDTKYAEEINYLIIKAQFRYAEKSTPRRQEERYSKVIDYYQDFVDDYPESKHRKEVDDIRKDSETNMAVAIKRWNEIKKSIEEQERELGVNQQRESTEEVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLS0</accession>
    <name>D7VLS0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Biotin synthase</fullName>
            <ecNumber evidence="3 13">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">bioB</name>
        <name evidence="16" type="ORF">HMPREF0766_11940</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:22060"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="EC" id="2.8.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3 13"/>
    <dbReference type="EMBL" id="ACHA02000007">
        <property type="protein sequence ID" value="EFK58222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000962.1">
        <property type="nucleotide sequence ID" value="NZ_GL379775.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11940"/>
    <dbReference type="EnsemblBacteria" id="EFK58222">
        <property type="protein sequence ID" value="EFK58222"/>
        <property type="gene ID" value="HMPREF0766_11940"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033172_1_2_10"/>
    <dbReference type="OrthoDB" id="940969at2"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="PTHR22976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00272">
        <property type="entry name" value="biotin_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 13 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 13" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 13 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="40"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFK58222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="330" mass="37032" checksum="C6A92608E9B5813B" modified="2010-10-05" version="1">MNTAIRNNWTKEEIQEIYDQPLLELVYRAATVHREWHRASEVQVCTLLSVKTGGCPEDCSYCGQAARYHTDIKVQALLPTETVIAHAQKAKDSGSTRFCMAAAWREVRDNRDFDRVIDMVKGVNDLGLEVCCTLGMLTEEQAVRLRDAGLHAYNHNLDTSEQYYEEIISTRKFDNRINTINHVRKAGITVCSGGIIGLGETHKDRISMLLTLATMPKHPESVPVNALARVKGTPLEHNPKVDIWDMVRMIATARIVMPASVVRLSAGRIEMTETEQAWCFMAGANSIFTGERETLLVTPNPGVSEDMQMFRNLGLKPMENKKSESSCQVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMC5</accession>
    <name>D7VMC5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_12122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001446.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12122"/>
    <dbReference type="EnsemblBacteria" id="EFK58130">
        <property type="protein sequence ID" value="EFK58130"/>
        <property type="gene ID" value="HMPREF0766_12122"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_10"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="294" mass="33122" checksum="5AB4973CDA3CCB22" modified="2010-10-05" version="1">MNLLIQELSKTYSNGVKALDHVNLEITPGMFGLLGPNGAGKSSLMRTIATLQKPDSGSIQFDNINVLENQMELRKVLGYLPQEFGVYPNLSAQELLQYFARLKGISSGADREKIIRRVLEVTNLWDVRNKSVSGYSGGMKQRFGIAQLLLNDPKLIIVDEPTAGLDPAERHRFLNVLREIGTNHTVIFSTHIVDDVRELCHELAILNGGKILLQGTPKDTISQLDDKIWVRIIGREQLDEYIGKFNVISTNYNQDNTLNIRVYSDSVPDETFVKAQVQLEDVYFVALKKDQRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMN0</accession>
    <name>D7VMN0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5 7" type="primary">purK</name>
        <name evidence="7" type="ORF">HMPREF0766_12250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992699.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12250"/>
    <dbReference type="EnsemblBacteria" id="EFK57177">
        <property type="protein sequence ID" value="EFK57177"/>
        <property type="gene ID" value="HMPREF0766_12250"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011534_0_2_10"/>
    <dbReference type="OrthoDB" id="1165275at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="112"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="177"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="264"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="380" mass="42983" checksum="6320F41C53ED9CA4" modified="2010-10-05" version="1">MAKDFYGELQLGILGGGQLGRMVIQEAINYNVNIHVLDPDKNAPCRKLCNRFEVGSLSDFHTVYNFGKDLDMLTIEIEKVNVDALEKLEEEGVQVFPQSRVIRLIQDKGLQKQFFKQNDIPTAPFQLISTKENLLNANINIPYIQKLRKDGYDGKGVKKIASQEDLEHAFEEPSMIEEWIDFEKEIAVIVARNDKGDISAFPLVEMEFNPQANLVEFLISPSTLSFEIQQQAEEIAKKIANDLQIVGLLAVEMFLTKQGEILVNELAPRPHNSGHQTIEGNYTSQFAQHLRAIFNLPLGNTSTRSNAVMINLLGEEGYEGLAKYEGIEEILDMEGVYLHLYGKKYTKPFRKMGHVCIVNDNRELAISNARKVQEILKVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMN7</accession>
    <name>D7VMN7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidyl-tRNA hydrolase domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yaeJ</name>
        <name evidence="2" type="ORF">HMPREF0766_12257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992711.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12257"/>
    <dbReference type="EnsemblBacteria" id="EFK57184">
        <property type="protein sequence ID" value="EFK57184"/>
        <property type="gene ID" value="HMPREF0766_12257"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089470_3_2_10"/>
    <dbReference type="OrthoDB" id="2047548at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="136" mass="15468" checksum="2B3F2C7475B8B1E4" modified="2010-10-05" version="1">MIANKEILLTELVFKFSRSGGAGGQHVNKVSSKVLLQWDVAGSTVFSEDQKAILFHALSNRINKDGVLQLESDNDRSQLKNKEIAIQRFLTIVDTALIPVKARKKTRIPYSKVVDRLDRKKRQSELKKSRSKKFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMV6</accession>
    <name>D7VMV6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltrans_SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_12326</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992829.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12326"/>
    <dbReference type="EnsemblBacteria" id="EFK57253">
        <property type="protein sequence ID" value="EFK57253"/>
        <property type="gene ID" value="HMPREF0766_12326"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051804_1_0_10"/>
    <dbReference type="OrthoDB" id="468283at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltrans_SAM" evidence="4">
        <location>
            <begin position="82"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="302" mass="34627" checksum="E2B4CA6F0923DEBC" modified="2010-10-05" version="1">MILKNTEIQLLTPQHWKDYELIDCGDFEKLERFGHLVLIRPEPQAVWPKTLSDAEWTKRYDIRFKGRSATSGDWVKKNPKAQDRWHIEYRNKDAAIKFRLGLTSFKHVGIFPEQAVNWDYISESVRSFKTDKPKVLNLFAYTGGASLIAKAAGADTTHVDSIKQVVTWANENQEISGLDNIRWVVEDALKFVKRELKRGNTYNGIILDPPAYGHGPKGEKWKLEDHIMEMMKDVVQLLDPKEHFLILNTYSLGFSSVIVENLIRTAFPKVENLEIGELYLQATAGPKLPLGVFGKFRKIAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN35</accession>
    <name>D7VN35_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional DNA primase/polymerase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992935.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12405"/>
    <dbReference type="EnsemblBacteria" id="EFK57332">
        <property type="protein sequence ID" value="EFK57332"/>
        <property type="gene ID" value="HMPREF0766_12405"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_332853_0_0_10"/>
    <dbReference type="OrthoDB" id="524800at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="1">
        <location>
            <begin position="17"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="859" mass="98973" checksum="779687D486090054" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN45</accession>
    <name>D7VN45_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4065 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992953.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57342">
        <property type="protein sequence ID" value="EFK57342"/>
        <property type="gene ID" value="HMPREF0766_12415"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110683_0_0_10"/>
    <dbReference type="OrthoDB" id="1702165at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025272">
        <property type="entry name" value="SocA_Panacea"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13274">
        <property type="entry name" value="DUF4065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4065" evidence="1">
        <location>
            <begin position="25"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="169" mass="19497" checksum="507F7E381F5F2C51" modified="2010-10-05" version="1">MVNFSLTANDIAPFFVKKKVSPLKLQKLLYYSQVWYVKKFDLKLFSDPIKAWVFGPVVPVIWNKFKIVRRSDIIAPIAHFYPCPTILPQNVLDHLEEIWNSYGHLSGSELVDLTHSEYPWNASRKGLLDTQPSDNEIIINNDTLAEYVLDRFNNIPYVKSSNSLGFFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN59</accession>
    <name>D7VN59_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992971.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12429"/>
    <dbReference type="EnsemblBacteria" id="EFK57356">
        <property type="protein sequence ID" value="EFK57356"/>
        <property type="gene ID" value="HMPREF0766_12429"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2439250_0_0_10"/>
    <dbReference type="OrthoDB" id="169425at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="90" mass="10184" checksum="207AC008BE0E2CB6" modified="2010-10-05" version="1">MIEQYPDKLVREDGSQLSCRFYPNNRSAGLKKIKDGAEVDVKFTIALPVDSPMLLVDEVITGYDRNGEVIVWQDSIAIFHRGQLHCVAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNI8</accession>
    <name>D7VNI8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993139.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12558"/>
    <dbReference type="EnsemblBacteria" id="EFK57485">
        <property type="protein sequence ID" value="EFK57485"/>
        <property type="gene ID" value="HMPREF0766_12558"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032YCE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133781_4_0_10"/>
    <dbReference type="OrthoDB" id="2076478at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="39"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="91" mass="10738" checksum="0EC6AD5AB1793BD9" modified="2010-10-05" version="1">MKVELITKEDLDSFKKELLEEIRRNRPHPRKAEKEPREWLKSYEIRELLGISAGTLQNLRLNGTLPFTKIGGLMYYRYEDIRKLMDGVDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNI9</accession>
    <name>D7VNI9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57486">
        <property type="protein sequence ID" value="EFK57486"/>
        <property type="gene ID" value="HMPREF0766_12559"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3122802_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="50" mass="5197" checksum="11CABEC813558AA8" modified="2010-10-05" version="1">MGIAERFFLKISVSEIAGKLFYCEDIAMGGKCALAAKSTGKKKAGSSNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNL1</accession>
    <name>D7VNL1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993166.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12581"/>
    <dbReference type="EnsemblBacteria" id="EFK57508">
        <property type="protein sequence ID" value="EFK57508"/>
        <property type="gene ID" value="HMPREF0766_12581"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030XU0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2435514_0_0_10"/>
    <dbReference type="OrthoDB" id="1783468at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="93" mass="10877" checksum="2B5BABD7AF12CB60" modified="2010-10-05" version="1">MVASLVIGIIFLVAGLVLRYWINRRKFYRRSSMGTEGFSSYESSIFIKLIEKVGKWIAYALIIFGLLSLWVYSREKKEKQQPDVTTEQPAQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNN1</accession>
    <name>D7VNN1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993191.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12601"/>
    <dbReference type="EnsemblBacteria" id="EFK57528">
        <property type="protein sequence ID" value="EFK57528"/>
        <property type="gene ID" value="HMPREF0766_12601"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZC9T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1480526_0_0_10"/>
    <dbReference type="OrthoDB" id="1891273at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="182" mass="21192" checksum="04619B61122EE281" modified="2010-10-05" version="1">MKQRDTNSIRYPKETDEKIEKLANSLGRSKKELFCQMVDYFYRSKKDPSDPGDEMLKRELSSGISRILSFIRQQEKDFLLPLFTDSDVLKTVSLRQKDVLEGIGKHLLAESEQTSVVAKRSVQILNGLKHLVSKQKEKEILKEQFAQLLDYYIKEREEMGWTTSGIKKEELIAHVRQSLKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNX8</accession>
    <name>D7VNX8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Urease accessory protein UreE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ureE</name>
        <name evidence="1" type="ORF">HMPREF0766_12698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993348.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12698"/>
    <dbReference type="EnsemblBacteria" id="EFK57625">
        <property type="protein sequence ID" value="EFK57625"/>
        <property type="gene ID" value="HMPREF0766_12698"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2371">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093757_3_0_10"/>
    <dbReference type="OrthoDB" id="1663151at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036118">
        <property type="entry name" value="UreE_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69287">
        <property type="entry name" value="SSF69287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="152" mass="17491" checksum="2C922169E151B73C" modified="2010-10-05" version="1">MLYISDNNYTDIPSGIAEELVYMEWYEVRKTLLERETSTGRMIRIQRESGEYLNEGQVVHLDDNYAVRLYIKPCDCIILHSKDAQMAGQFCFDVGNRHLPVFCLNEASFAVAYDGRLYSALSAKYTGHIELTSARLLPDQALHMFRKNKISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP11</accession>
    <name>D7VP11_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5017 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993416.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12731"/>
    <dbReference type="EnsemblBacteria" id="EFK57658">
        <property type="protein sequence ID" value="EFK57658"/>
        <property type="gene ID" value="HMPREF0766_12731"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503063W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066814_0_0_10"/>
    <dbReference type="OrthoDB" id="1733299at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032185">
        <property type="entry name" value="DUF5017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16409">
        <property type="entry name" value="DUF5017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5017" evidence="1">
        <location>
            <begin position="19"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="312" mass="34689" checksum="0F91E057F151AAA9" modified="2010-10-05" version="1">MKKIWINTIAILSIFYMNSCQKDIPQKVSFEANPDRMEIGLQDSVTFTYTGYADVISFYSGEKGREYQYRDRTEMEGLSMELSIASRVLYGSQEKNVKLMYSTAFSGNYSAAGIKEEEWTDISDKFTWSTAAVPNGIAATTTASGPADLSSLLVPGKPIYFAYRYESQAATSAATGGRSWRLPVFDLATRTPEGTRAVLATVRTAGWKIVPVLTGVNKASYWTISSSDPYLFFTPNSTLEPHIHWVITAPFAPTSVKPDKPLVQKAMIDPMPQRLTYKFTAPGTYKVTFVAQNVNYKGEETAVKQFDIKVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP58</accession>
    <name>D7VP58_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">recN</name>
        <name evidence="8" type="ORF">HMPREF0766_12778</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RecN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993480.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12778"/>
    <dbReference type="EnsemblBacteria" id="EFK57705">
        <property type="protein sequence ID" value="EFK57705"/>
        <property type="gene ID" value="HMPREF0766_12778"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0497">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018297_3_1_10"/>
    <dbReference type="OrthoDB" id="1074831at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="7">
        <location>
            <begin position="2"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="165"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK57705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="553" mass="61851" checksum="2C6D9FBAEC9912F7" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP65</accession>
    <name>D7VP65_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Coproporphyrinogen-III oxidase</fullName>
            <ecNumber evidence="7">1.3.98.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hemN</name>
        <name evidence="11" type="ORF">HMPREF0766_12785</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>coproporphyrinogen III + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX</text>
            <dbReference type="Rhea" id="RHEA:15425"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="1.3.98.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7 9">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (AdoMet route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the anaerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.98.3" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993493.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12785"/>
    <dbReference type="EnsemblBacteria" id="EFK57712">
        <property type="protein sequence ID" value="EFK57712"/>
        <property type="gene ID" value="HMPREF0766_12785"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027579_3_0_10"/>
    <dbReference type="OrthoDB" id="1130951at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051989">
        <property type="term" value="F:coproporphyrinogen dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004558">
        <property type="entry name" value="Coprogen_oxidase_HemN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000167">
        <property type="entry name" value="HemN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00538">
        <property type="entry name" value="hemN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="49"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="70"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="117"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000167-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000167-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK57712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="454" mass="52250" checksum="F783FE53E18866C8" modified="2010-10-05" version="1">MENKNIEHLIRKYNVAAPRYTSYPTVPFWENDRFNTPEWEERVKQTYASSTGNGVSIYIHLPFCEDLCTYCGCNTRITKNHKVEDPYITAVLKEWAMYKQLLEDTAVKISEIHLGGGTPTFFQPANLERLITGILDGNTCAEDASFSFEAHPANTTESHLKTLYRLGFRRLSLGIQDFDAKVQFVINRLQTVEDVERVVAQARAIGYTSINFDLIYGLPFQTESTITETIDKALEMQPDRISFYSYAHVPWIKPGQRRFTEMDLPEGESKLRLYKLGKQMIGQEGYEDVGMDHFARPDDELFLASRAGRLHRNFMGYADRYTPLMIGLGVSSISDAWTGFAQNVKTVEEYHRLIAEGKLPVVKGHLLTGEDEILRRYILHMMCRGEMEFERGFRLNTKIKERLEPMFLDGLLTMGADNVRITETGKSFLRNICMAFDERLQQTKEQTRLFSQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP84</accession>
    <name>D7VP84_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12804"/>
    <dbReference type="EnsemblBacteria" id="EFK57731">
        <property type="protein sequence ID" value="EFK57731"/>
        <property type="gene ID" value="HMPREF0766_12804"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3047">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100971_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107101" evidence="1">
        <location>
            <begin position="21"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="149" mass="16382" checksum="8573EEDF73AC1EC0" modified="2010-10-05" version="1">MKKLLLTVTAIAGFSFMTQAQEFGYKKTDFIVEGFFQSSNKNDKTADSKKSNLLFNPKFGYFVTDKIAVGAGLGFSNKKEVTQLSLGKAEAKINVFSAAVFGRYYFLEIGTRFKTYAELAGSYASISTEKTINSNSAKEPKANRFAVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPE2</accession>
    <name>D7VPE2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993634.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12862"/>
    <dbReference type="EnsemblBacteria" id="EFK57789">
        <property type="protein sequence ID" value="EFK57789"/>
        <property type="gene ID" value="HMPREF0766_12862"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098677_1_0_10"/>
    <dbReference type="OrthoDB" id="1807879at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009781">
        <property type="entry name" value="DUF1345"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07077">
        <property type="entry name" value="DUF1345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="219" mass="24810" checksum="B7E21634B1D889F9" modified="2010-10-05" version="1">MQSKELFIHRLRPIHRGLIALVLAIVVFFVFPRNENIMVQLLYSWLAFSLTYLLIAWATFYTMPIQKIIKLATIEDGSRIVVTLFILLASFTCLFAVLFVIESPADNPSLNIRNIGIAVASMIASWALVHTIYTFHYARLYYNDENKKAGGLDFPGSEKPDYLDFAYFSFVLGCTFQVSDVEISNKKIRHVALFHGLLSFALNTFVVALTINIVAGFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPE9</accession>
    <name>D7VPE9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zn_protease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993647.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12869"/>
    <dbReference type="EnsemblBacteria" id="EFK57796">
        <property type="protein sequence ID" value="EFK57796"/>
        <property type="gene ID" value="HMPREF0766_12869"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099424_1_0_10"/>
    <dbReference type="OrthoDB" id="1576021at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008503">
        <property type="entry name" value="Put_Zn_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05618">
        <property type="entry name" value="Zn_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_protease" evidence="1">
        <location>
            <begin position="7"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="144" mass="16861" checksum="019A08AF3915AF5D" modified="2010-10-05" version="1">MAEMRTIGWYETVDLPELGLYNFKAKIDTGARTSVLHCEEYHIEEENGHKFIQCTIIDDFETESTRVIRFPIVRQGVVKSSFGHSEIRYMIFTKIKLFDQLYNIKLSFRNRSGMKFPMLLGRNFISKKFLVDVSKYNLSESSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPJ0</accession>
    <name>D7VPJ0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12910"/>
    <dbReference type="EnsemblBacteria" id="EFK57837">
        <property type="protein sequence ID" value="EFK57837"/>
        <property type="gene ID" value="HMPREF0766_12910"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3122803_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="50" mass="5949" checksum="333637C40A294F91" modified="2010-10-05" version="1">MKKKTSQNTINTFTATYYDKENIFKKSQITSKLSFCREGNPQIIYKIIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPL2</accession>
    <name>D7VPL2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain protein</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993787.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12932"/>
    <dbReference type="EnsemblBacteria" id="EFK57859">
        <property type="protein sequence ID" value="EFK57859"/>
        <property type="gene ID" value="HMPREF0766_12932"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049344_3_3_10"/>
    <dbReference type="OrthoDB" id="1687413at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="44"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="248" mass="29111" checksum="D4A757469F9A8261" modified="2010-10-05" version="1">MKKNVDRFTDRVVDYEKYRPSYPNQILSLLTQEIGFTKDWLVADIGSGTGISTKLFVDNGNNTFGIEPNQAMREACIHHFKKNRNFIAVNATAEDTKIDDHCVDLIFAGQSFHWFDKVKTRAEFQRILKPEGHIVLVWNQRSPEDEFQRAYEEFLVRHIPEYQTVTQKNITDEHIHGFFAPKAIRKFSLPNQQTFDLKAFFGRVKSSSYFPNEESESKKLYEGLRELFDEYAIDKRLVFNYQTDIYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPL5</accession>
    <name>D7VPL5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_12935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993790.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12935"/>
    <dbReference type="EnsemblBacteria" id="EFK57862">
        <property type="protein sequence ID" value="EFK57862"/>
        <property type="gene ID" value="HMPREF0766_12935"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_1_3_10"/>
    <dbReference type="OrthoDB" id="554994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="34"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="273"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="506" mass="56735" checksum="314A8AAD668E65B6" modified="2010-10-05" version="1">MLIFKNQKVMKTNISTYISATLLALLVLSSCSKDFLDRKPLGQLTEEDLPAGSLEGQVLAIYAGLRSEGTSGLPYVGVHNMRSDDAEIGSSVGDEAGSAPNTDDFQYTTNFWLWGNYWTDHYKLIALTNTAIETADSLGDQSPEVARGLAEAKFFRAWAYFNLVRAFGEVPKIDFRVRDQKESILPKSPIADIYALIDADLEYATQHLPLNWESRFIGRITQGAAFAVQAKTFLARQQYSKALAASRMVINSGQYNLSVAYNQIFRESSENSKESVFEIQAYYAQGQTNLGITYAGRQGVRGSGAMNLGWGWNVPNERLAKAFEEGDPRKDETLLYAGRVNTPYVELIPAATATVPRAYWNKKVYTDPKIRTATGSQAGEWFNFRVIRYADVVLMAAEAANEVGEQEAALTYLEQIRVRARGGNNAILPKVTTTNQQELRLAIRHERQVELGMENERFFDLIRWNIDAETFKDAGKTNYQLRNRYLPIPQNEIDRSGGVLIQNPNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPQ8</accession>
    <name>D7VPQ8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-70 region 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12978</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993857.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12978"/>
    <dbReference type="EnsemblBacteria" id="EFK57905">
        <property type="protein sequence ID" value="EFK57905"/>
        <property type="gene ID" value="HMPREF0766_12978"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_4_1_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="36"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="134"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="213" mass="25811" checksum="7E87FB63751E4C60" modified="2010-10-05" version="1">MNILHLGHMPETRRLHQQWLVSVREQDDRYAFAEIYHCYWKELYIHAVKRVRDEQQAEDILQELFVQFWERRATLDTGMNLRAYLYGMLKFKLIDFFNSNKAQQKLLDGLAEHMFDYVQQHPEELEIYLAMEKLLEEELEAMPNNMQQAVLLRWEHYSIKEIARRLNLSEQTVKNNLTEATKRLQRGLTVRSKDVYGPLFLLFVQYMQEWLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPR0</accession>
    <name>D7VPR0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_12980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993860.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12980"/>
    <dbReference type="EnsemblBacteria" id="EFK57907">
        <property type="protein sequence ID" value="EFK57907"/>
        <property type="gene ID" value="HMPREF0766_12980"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006935_0_0_10"/>
    <dbReference type="OrthoDB" id="76759at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010917">
        <property type="entry name" value="TonB_rcpt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01156">
        <property type="entry name" value="TONB_DEPENDENT_REC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="228"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="552"/>
            <end position="1105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK57907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1106" mass="125140" checksum="569A642E8CCE497E" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ16</accession>
    <name>D7VQ16_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993989.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13070"/>
    <dbReference type="EnsemblBacteria" id="EFK55867">
        <property type="protein sequence ID" value="EFK55867"/>
        <property type="gene ID" value="HMPREF0766_13070"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_24_0_10"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043906">
        <property type="entry name" value="Gfo/Idh/MocA_OxRdtase_bact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19051">
        <property type="entry name" value="GFO_IDH_MocA_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="44"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C2" evidence="2">
        <location>
            <begin position="208"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK55867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="476" mass="52615" checksum="C6765B13A9FDA85F" modified="2010-10-05" version="1">MDKNSSTSRRDFIRSAATAAAAFMIVPRHVLGGTGFIAPSDKLQVAGIGVGGKGASDINSFFASGKADIAFLCDVDDTRAAGTVKKFPKAKYYKDFREMLDKEHKHIDAVSISTPDHNHAIQSLAAMQLGKHVYVQKPLTHDVWEARVLTDAAKKYKVVTQMGNQGASNDGPRQVREWYEAGIIGDVHTVYCWTDRPVWPSGIPWPTQKGQIPKELDWDLWLGTAPQRDYIEKLVPFNWRGWWDYGTGALGDMGCHLLEVPFSTLGLTYVQDVQASVGTVYVDEFKRGYFPESCPPSSHATLTFPKGNRTAGPVTLHWMDGGIQPPRPDELGANEIFGDGGNGILLVGTKGKILADTYGQNARLLPTSRKENVAQKYARVAGGAEGHYGQWVEACIAGYGKKEVSSPFEIAGPLTEALLMANLAIRGADMRINNKYPGRNLKLLWDNQQMKVTNFDEVNQFVKRNYRTGWDIKYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ61</accession>
    <name>D7VQ61_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gdhA</name>
        <name evidence="9" type="ORF">HMPREF0766_13115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994062.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13115"/>
    <dbReference type="EnsemblBacteria" id="EFK55912">
        <property type="protein sequence ID" value="EFK55912"/>
        <property type="gene ID" value="HMPREF0766_13115"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_2_1_10"/>
    <dbReference type="OrthoDB" id="1184827at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004353">
        <property type="term" value="F:glutamate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="8">
        <location>
            <begin position="203"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="6">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK55912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="443" mass="49155" checksum="EEAFD06680A44B35" modified="2010-10-05" version="1">MSKVYNTFIDYIEKRNPNEPEFLQAVTEVAEDLIPYIEQHQPELLKMKVLERIAEPERVISFRVTWLNDKNEIEVNRGYRVQMNSAIGPYKGGLRFAPNVNLSILKFLAFEQVFKNSLTSLPIGGGKGGSDFNPKGKSDTEIMKFCQSFISELYRHIGAETDVPAGDIGVGEREIGYMFGQYKRLQNNFTGVLTGKGANWGGSYIRPEATGYGLLYFVSCIYDYRSEELKDKIVAISGAGNVAFYAAEKAIQLGAKVITLSNSQGVLYDEQGITSEKLAFIATIGRDLDKYISKYPDAKYYEGKKPWEFKCDIALPCATQNELDGEDAQKLIDNGCTCVAEGANMPSTAEAIKLFHKARLIFAPGKAANAGGVAVSGLEMSQNSIREQWTKEKVDKKLHGIMENIHRTCVKYGHEDNYINYLKGANIGGFLKVAKAMIAQGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ75</accession>
    <name>D7VQ75_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma factor regulatory protein, FecR/PupR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994079.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13129"/>
    <dbReference type="EnsemblBacteria" id="EFK55926">
        <property type="protein sequence ID" value="EFK55926"/>
        <property type="gene ID" value="HMPREF0766_13129"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050192_1_0_10"/>
    <dbReference type="OrthoDB" id="1381035at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032508">
        <property type="entry name" value="FecR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16344">
        <property type="entry name" value="DUF4974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="161"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4974" evidence="3">
        <location>
            <begin position="294"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK55926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="367" mass="42207" checksum="B29A74AD31903380" modified="2010-10-05" version="1">MDKYQVKALLEKFDKGNCTAEELALLEEWYLNWRQTPVHLTQEQIDESLDRIWNRLQHARKKPVKLYNLRFVIRSIAAILVLAIGISLYFYRYQSVNKHVTEETVNDIEPGSNKAWIVLADGRKIDLSKDKTGVKVLKGQLTYNDGSKLLDEPELINQPVTLQTPRGGTYQVQLPDGTEVWLNAATKLIYYPVLSNKGKRIVDLEGEAYFEVAKDKAHPFIVQSKAQVVEVLGTHFNISSYPDDMLSKTTLLEGRIKINHNMLLPGQQAILKDKNLSIHHADTEHTMAWKNGDFVFKGENFKEMMQKIARWYDVQIEYSENAATDQVELAGWISRKSKLSEVLNRIQRAGKIHFKIEGRKIIVEKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQE2</accession>
    <name>D7VQE2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994230.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13196"/>
    <dbReference type="EnsemblBacteria" id="EFK55993">
        <property type="protein sequence ID" value="EFK55993"/>
        <property type="gene ID" value="HMPREF0766_13196"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134999_0_1_10"/>
    <dbReference type="OrthoDB" id="1536415at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="152" mass="17168" checksum="28DB86227F75A2C4" modified="2010-10-05" version="1">MKDPLQLKERLVKHIKETTDRRLLEIDTALVQAQESANDDTKSSAGDKYETSREMIQQDINRLQQQRAEVIRELDIINKIEQEGTEVGKLGALVVTDRFTYFVATSLGQLVIDGNKYAVVSAQSPIGKQLIGKEKGQDFEFNGIRQTIKGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQG5</accession>
    <name>D7VQG5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994274.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13219"/>
    <dbReference type="EnsemblBacteria" id="EFK56016">
        <property type="protein sequence ID" value="EFK56016"/>
        <property type="gene ID" value="HMPREF0766_13219"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1577525_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="169" mass="19724" checksum="FB93895ABBCA243E" modified="2010-10-05" version="1">MKQVIKNRYLKVFRFSFVEEASTFFKNQKAERSLSIEDTLGDSYYCYVCYHSLTKEKQFVLSFSSDESEDNLNFLFWENIFVLDTGTNIYLIDESLNIKTSLETTTPLVGLYLISNDKLLILEEAYLRIINYNGDIVRAELFGLIEDFSIKDNLLSIQTSEENRVIELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQH3</accession>
    <name>D7VQH3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13227"/>
    <dbReference type="EnsemblBacteria" id="EFK56024">
        <property type="protein sequence ID" value="EFK56024"/>
        <property type="gene ID" value="HMPREF0766_13227"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_1_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="206" mass="23575" checksum="6457DF8680CF3A39" modified="2010-10-05" version="1">MKESNRIGLKSLIFDTIDDTFSLVTMNFSLQPLLENDYVALVPLSETDFEPLYAAASDEKIWEQHPNKDRWKREVFRLFFEGAVNSKGAFKIIDKQTGEIAGSTRFYDYDEEARSILIGYTFYATKYWGKGINPAVKKMMLDYIFQYVDTVYLHVGADNIRSQTAVERIGGVSVGKREVAYYGEPSRTNVVYHITKESWLSTPGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQL0</accession>
    <name>D7VQL0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994367.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13264"/>
    <dbReference type="EnsemblBacteria" id="EFK56061">
        <property type="protein sequence ID" value="EFK56061"/>
        <property type="gene ID" value="HMPREF0766_13264"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031GGW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1812325_0_0_10"/>
    <dbReference type="OrthoDB" id="1792552at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="132" mass="14738" checksum="E6CDF3BA070A19F6" modified="2010-10-05" version="1">MKNIIKGLLLTLCISMAGCQKDYPMDSDGLLITNRAECYVSNFELLGADFQTVRTKAAVIDTVAQTIKVEVMFGTDLRNLYPQFSLVADALLDPKIVGKEDFSNLSTPRKWTVVSGNRKVRKEYTVTLTVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQM7</accession>
    <name>D7VQM7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994391.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13281"/>
    <dbReference type="EnsemblBacteria" id="EFK56078">
        <property type="protein sequence ID" value="EFK56078"/>
        <property type="gene ID" value="HMPREF0766_13281"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_1_10"/>
    <dbReference type="OrthoDB" id="1497607at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="182" mass="21590" checksum="22908C025635A168" modified="2010-10-05" version="1">MKNNKKYIFTSERLGFRNWDLADIDKLYEINTDRKVMEFFPDVSTKQQTTEFVHRMKRQFEEKAFCYFAVDRLDNREFIGFIGLSEQTYAADFTPCIDIGWRISSTEWNKGYATEGAKKCLDYALNVLKLQEVYAVAPKINLKSEHIMKKIGLEKQYEFEHALLINNERLRTCVLYKTKGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQP5</accession>
    <name>D7VQP5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994414.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13299"/>
    <dbReference type="EnsemblBacteria" id="EFK56096">
        <property type="protein sequence ID" value="EFK56096"/>
        <property type="gene ID" value="HMPREF0766_13299"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112936_1_0_10"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="156" mass="18579" checksum="ED1600214935A6FF" modified="2010-10-05" version="1">MIHRLYQEQQLNCDLQTAWTFFSAANNLSKITPPEMKFTVLTSFDNDEIYEGMLIRYRVTPLFGITMNWETRITQVDFQKSFTDFQAKGPYKLWNHHHEFIPNEKGVLMKDTVDYELPFGVLGELAHNWIVKPRLEEIFRYRRQVLDQKFGDTPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQS7</accession>
    <name>D7VQS7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gltR</name>
        <name evidence="3" type="ORF">HMPREF0766_13331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994457.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13331"/>
    <dbReference type="EnsemblBacteria" id="EFK56128">
        <property type="protein sequence ID" value="EFK56128"/>
        <property type="gene ID" value="HMPREF0766_13331"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_10"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="122" mass="13299" checksum="CA5406EB99ADB6F2" modified="2010-10-05" version="1">MRKVKRILLADDDAGIVDSTTMLLEMMGYNVDSTLDGSIVPQVVTSTSSPDLVIMDIWMAGIDGREICRIIKNDPVTSKIPVLMISASKDIKASAIESGADAFLEKPFELQELIDTIEKLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQX2</accession>
    <name>D7VQX2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994514.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13376"/>
    <dbReference type="EnsemblBacteria" id="EFK56173">
        <property type="protein sequence ID" value="EFK56173"/>
        <property type="gene ID" value="HMPREF0766_13376"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_51_0_10"/>
    <dbReference type="OrthoDB" id="1360387at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="297"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="330"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="2">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="448" mass="48758" checksum="A05ABA90F4149DA2" modified="2010-10-05" version="1">MSQSFIKACEDGKRKIAEILLEKQQVDVRYTDEMGRTALHYAAHRGYLDLVKQLISAGADISYEEHNGETPLFFAILQKQKQTALYLIEQGANLQINDFQGNSLLHVAASSGQQEIAEKLLHEGLDVNALNNQAETPLLLAVQGKFPPVVQVLLHNGANVDLTDRNGNTALNTAVSNSSVPIVNMLLDNGATVNLLNDQSESPLLIATKLGNRIIAQKLVETGADIFTESADGVSPVWYVCGSNQKELLSLFISKGLSPDYARPVDSFDGKDGQYIQKLIARTGTRTFILGYEPHYAGETLLQTATKSGYLSLMKVLIDSGAQIDKQDASGNTALHYAASYGKKDAVRFLLANGSSPDITNVLEQKAIDYSNIQGFNEITALLIEYGATPDPVVSGSVSPVKEVSIEEKPPMDMAQKKQALFDLKDLLDAGIISKEEFEQEKSKILQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR07</accession>
    <name>D7VR07_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13411"/>
    <dbReference type="EnsemblBacteria" id="EFK56208">
        <property type="protein sequence ID" value="EFK56208"/>
        <property type="gene ID" value="HMPREF0766_13411"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_15_3_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="12"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="149"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="297" mass="33647" checksum="BB7E9D32F62747BE" modified="2010-10-05" version="1">MGQEDNSFMKKSYLVLHVAVILAGFTGIFGKLITVNEGLLVWYRVLFSAIILWMILKLFHVSRQITTKEKFNIAKIGMFITLHWVFFYASIKYSNISVGVVCYCLTSFFTAVFDPLINRRKFNVNELLLSVLTLAGIALIFHFDSSYQLGIGLGIISSAFAALYTLFNERIVKNYDSRLINYYQMIGGTIGLGILMPFYLYAFPVQTVLPDLKDIGYLVILASFCTVGLYILFAESLKKIPAFTVNLSFNLEPVYAIILAFLFFNESKQLNLFFYIGLLLVMTSVVLQTIVSLKRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRG1</accession>
    <name>D7VRG1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aconitate hydratase A</fullName>
            <ecNumber evidence="4">4.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Iron-responsive protein-like</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">RNA-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">acnA</name>
        <name evidence="16" type="ORF">HMPREF0766_13565</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994756.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13565"/>
    <dbReference type="EnsemblBacteria" id="EFK56362">
        <property type="protein sequence ID" value="EFK56362"/>
        <property type="gene ID" value="HMPREF0766_13565"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_2_2_10"/>
    <dbReference type="OrthoDB" id="363064at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase" evidence="14">
        <location>
            <begin position="34"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="15">
        <location>
            <begin position="558"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFK56362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="755" mass="81827" checksum="24319B3F41552C92" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRG3</accession>
    <name>D7VRG3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994758.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13567"/>
    <dbReference type="EnsemblBacteria" id="EFK56364">
        <property type="protein sequence ID" value="EFK56364"/>
        <property type="gene ID" value="HMPREF0766_13567"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056519_2_0_10"/>
    <dbReference type="OrthoDB" id="1815576at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="42"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="278" mass="31813" checksum="A957F42EA1F89EF3" modified="2010-10-05" version="1">MQLHTIDTGFFKLDGGAMFGVVPKSLWQRTNPADEKNLCTWATRLLLIEDGSRLILVDTGLGDKQDAKFFGHYDLHGDDTLDKSLAKYGYNRQDITDVFLTHLHFDHCGGAIVRDGDKLIPSFANATYWSNEKHWNWATVDPNPREKASFLAENILPIQESGQLRFIGEGQALTEHIDIRIANGHTEAMMLPQIRYKGKTILYMADLLPSVGHIPIPYVMSYDVRPLTTMQERKSYWEEIADQEYILFLEHDPVNECCTLQHTEKGIRLKDTFRLSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRJ9</accession>
    <name>D7VRJ9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol phosphodiesterase</fullName>
            <ecNumber evidence="2">4.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Phosphatidylinositol diacylglycerol-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphatidylinositol-specific phospholipase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">plc2</name>
        <name evidence="7" type="ORF">HMPREF0766_13603</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol</text>
            <dbReference type="Rhea" id="RHEA:17093"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58484"/>
            <dbReference type="EC" id="4.6.1.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.13" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994803.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13603"/>
    <dbReference type="EnsemblBacteria" id="EFK56400">
        <property type="protein sequence ID" value="EFK56400"/>
        <property type="gene ID" value="HMPREF0766_13603"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024117_3_1_10"/>
    <dbReference type="OrthoDB" id="941044at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004436">
        <property type="term" value="F:phosphatidylinositol diacylglycerol-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLCXc" evidence="6">
        <location>
            <begin position="52"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="320" mass="35846" checksum="37697E4D89102C83" modified="2010-10-05" version="1">MHMKLYINYILLLLVVLTSCNSSEIEKLQLSQSSASVAQVLPEGTNWMSFIQGERKLSALSIPGTHDAGARYEPVSGTAKTQNLTIAEQLNAGVRFLDVRCRFVDDNFAIHHGPVYQHLNFDDVLQSCKSFLQAHPSETIIMSVKEEHTPNGNSMTFEERFIKYTDAYSGLFRLEADIPSLQQARGKIVLLRRFSSAQALGIQANNGWSDNTSFTIQNQESTLQVQDAYQVSSNTDKWNAIHTLLNTSKNTDPASGTLFLNFSSGYQKKLWVIPNIPSVSNEINPKLLNYFNQQTTSHFGVIITDFIHADLAKSIFNTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRK0</accession>
    <name>D7VRK0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994804.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13604"/>
    <dbReference type="EnsemblBacteria" id="EFK56401">
        <property type="protein sequence ID" value="EFK56401"/>
        <property type="gene ID" value="HMPREF0766_13604"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_2_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107284" evidence="1">
        <location>
            <begin position="25"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="130"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1031" mass="113074" checksum="08290859EBB5567F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRM6</accession>
    <name>D7VRM6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994872.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13630"/>
    <dbReference type="EnsemblBacteria" id="EFK56427">
        <property type="protein sequence ID" value="EFK56427"/>
        <property type="gene ID" value="HMPREF0766_13630"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093838_0_1_10"/>
    <dbReference type="OrthoDB" id="1382281at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019613">
        <property type="entry name" value="DUF4198"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10670">
        <property type="entry name" value="DUF4198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="237" mass="26552" checksum="FE4984FB51346C35" modified="2010-10-05" version="1">MKIITQLFLILILLGGKQVAMAHAIWIESKASASKNQPHDVKIFYGEYASGEKESTDKWYSDLKNLEVWLTTPDNQRVKLDVKDEQGHLATSFVPEKDGVYYISTVHATKDLGGTTKYNFSSLVPVRVGKLAISATSPKDLPFSVEKITTNGKNKSVIEVLVSSNGKAVKDAEVIVMSETGWTKTFKTNENGVVSFSPQWKGNYVVEASQMNDEAGRWHDKDYTRNWHGTTTFFEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRP1</accession>
    <name>D7VRP1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994902.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13645"/>
    <dbReference type="EnsemblBacteria" id="EFK56442">
        <property type="protein sequence ID" value="EFK56442"/>
        <property type="gene ID" value="HMPREF0766_13645"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_452619_0_0_10"/>
    <dbReference type="OrthoDB" id="2105760at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107854" evidence="1">
        <location>
            <begin position="21"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="603" mass="66020" checksum="F84BF2560AD59B1C" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRX8</accession>
    <name>D7VRX8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995135.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56529">
        <property type="protein sequence ID" value="EFK56529"/>
        <property type="gene ID" value="HMPREF0766_13732"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50339XJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2934081_0_0_10"/>
    <dbReference type="OrthoDB" id="2079190at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="63" mass="7171" checksum="6EEEAB1A78F56530" modified="2010-10-05" version="1">MEKNKASSFIFGITAVIVGSALYKQIDFEHFKVLHKGLAIIYGLTFAFSVFILIKNFRNRSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS21</accession>
    <name>D7VS21_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase family protein</fullName>
            <ecNumber evidence="3">1.5.1.34</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nfnB</name>
        <name evidence="3" type="ORF">HMPREF0766_13775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitroreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.34" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995235.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13775"/>
    <dbReference type="EnsemblBacteria" id="EFK56572">
        <property type="protein sequence ID" value="EFK56572"/>
        <property type="gene ID" value="HMPREF0766_13775"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_4_1_10"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004155">
        <property type="term" value="F:6,7-dihydropteridine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02149">
        <property type="entry name" value="NfsB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033878">
        <property type="entry name" value="NfsB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="199" mass="22726" checksum="DB21AFDAB0174209" modified="2010-10-05" version="1">MTFLKLAESRYTTKSYVTAKKISDEKIETLKDIIRLSPSSINSQPWKFAFVSDEKVKSELAAASYWNAEKINQASHLIVFSAIDDTDAFERQINEHLPEGSVNYYNRFLKPKGEGEIKSWLQHQVYLSLGFFLSACASLEIDSTPMEGIQNEEYDKILKWEGYKTLFAVAIGYRNPADSNQPSLNPKFRLTSEQIIHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS54</accession>
    <name>D7VS54_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995314.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13808"/>
    <dbReference type="EnsemblBacteria" id="EFK56605">
        <property type="protein sequence ID" value="EFK56605"/>
        <property type="gene ID" value="HMPREF0766_13808"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_438630_0_0_10"/>
    <dbReference type="OrthoDB" id="1623251at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027375">
        <property type="entry name" value="DKNYY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13644">
        <property type="entry name" value="DKNYY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="623" mass="72143" checksum="2723E30C7DEDE04F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS64</accession>
    <name>D7VS64_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_S15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995336.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13818"/>
    <dbReference type="EnsemblBacteria" id="EFK56615">
        <property type="protein sequence ID" value="EFK56615"/>
        <property type="gene ID" value="HMPREF0766_13818"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048587_0_1_10"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107866" description="Peptidase_S15 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S15" evidence="2">
        <location>
            <begin position="60"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="352" mass="39284" checksum="9BADDE2DA7AD4A7C" modified="2010-10-05" version="1">MKRLSVLAVVILMFLGQSSAQHTNNKNSEKMNYTAKTEHYTFELSDKVTRQKVTFKNRYGITLSGDLYIPKNNGSEPLAALAISGPFGAVKEQSSGLYANQMAERGFIALAFDPSYTGESGGEPRNIASSDINTEDFSAAVDFLGIQKNINRNKIGIIGICGFGGFALNATAIDKRIKAVVTTSMYDIPRASSKGYYDKVTLEERTKTLEQMSQQRWKDAETGVPAYGNCPNPDTLKGDEPQFVKDYFDYYKTKRGFHTRSVNSNAAWTLTNGFSLMNMPILSYIKEISPRPILLIAGENAHSRYFSEDIYKMAAEPKELMIIPNAVHVDLYDKVDIIPFGKLETFFKDNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS69</accession>
    <name>D7VS69_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995356.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13823"/>
    <dbReference type="EnsemblBacteria" id="EFK56620">
        <property type="protein sequence ID" value="EFK56620"/>
        <property type="gene ID" value="HMPREF0766_13823"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_9_0_10"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="13"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="193" mass="22703" checksum="77DF76E00C52AF33" modified="2010-10-05" version="1">MQSDITISSYLESFELFTDSEVDVIASHFKPKSIKKGDYFIREGNYSSEVALVVSGIFRSYYLNDNMDEITYCFRFPQELLAAYSSLIQQTPSLENIQAISNAELVVISADDIRKLDDLYPGWIRFQKMIAEQQYIELEQRIFQLQRQQAIQRYTSLLQNQPDYIRLIPLQYLATYLGITQRHLSRIRREIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSL1</accession>
    <name>D7VSL1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multidrug resistance protein, SMR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">emrE</name>
        <name evidence="6" type="ORF">HMPREF0766_13965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995628.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13965"/>
    <dbReference type="EnsemblBacteria" id="EFK56762">
        <property type="protein sequence ID" value="EFK56762"/>
        <property type="gene ID" value="HMPREF0766_13965"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133067_0_2_10"/>
    <dbReference type="OrthoDB" id="1921902at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK56762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="110" mass="12035" checksum="B2FE53CB72392E0A" modified="2010-10-05" version="1">MKSYLFLLLAIVFEIIATTFLKKSEQFTQLKPSIITVLGYLAAFYFLSMTLRTIPVGIAYAIWSGVGIVLISIVGIVLFRQTPDLPAVIGLTLIIAGVIVINVFSKMSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSV3</accession>
    <name>D7VSV3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_14057</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995834.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14057"/>
    <dbReference type="EnsemblBacteria" id="EFK56854">
        <property type="protein sequence ID" value="EFK56854"/>
        <property type="gene ID" value="HMPREF0766_14057"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_1_0_10"/>
    <dbReference type="OrthoDB" id="384945at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="24"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="285"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="567" mass="62934" checksum="B0E1DFCB56ACCE48" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT08</accession>
    <name>D7VT08_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fadJ</name>
        <name evidence="10" type="ORF">HMPREF0766_14112</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995940.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14112"/>
    <dbReference type="EnsemblBacteria" id="EFK56909">
        <property type="protein sequence ID" value="EFK56909"/>
        <property type="gene ID" value="HMPREF0766_14112"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_16_3_10"/>
    <dbReference type="OrthoDB" id="977512at2"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="9">
        <location>
            <begin position="297"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="8">
        <location>
            <begin position="479"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK56909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="693" mass="77076" checksum="8BA5142CBF2DDA12" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT09</accession>
    <name>D7VT09_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-methylcitrate dehydratase</fullName>
            <ecNumber evidence="5">4.2.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prpD</name>
        <name evidence="5" type="ORF">HMPREF0766_14113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.79" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995942.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14113"/>
    <dbReference type="EnsemblBacteria" id="EFK56910">
        <property type="protein sequence ID" value="EFK56910"/>
        <property type="gene ID" value="HMPREF0766_14113"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021803_1_0_10"/>
    <dbReference type="OrthoDB" id="688128at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012705">
        <property type="entry name" value="2Me_IsoCit_deHydtase_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="PTHR16943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="SSF103378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02330">
        <property type="entry name" value="prpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE_PrpD" evidence="3">
        <location>
            <begin position="18"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE_PrpD_C" evidence="4">
        <location>
            <begin position="287"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="483" mass="53782" checksum="21145931254D8500" modified="2010-10-05" version="1">MASIISNERPQPDQVLTDIVDYVLDYKVESDVAWRTAFYCFLDTLGCGFEALTYPACTKLLGPVVPGTIVPNGAKVPGTAYQLDPIQAAFNIGTIVRWLDFNDTWLAAEWGHPSDNLGGILATADWLSRTRVANGEKPLKAKVVLEAMVMAHEIQGVLALENSFNKVGLDHVILVKVASTAVVGKLLGLNREELINAVSLAFVDGQALRTYRHAPNTGSRKSWAAGDATSRAVRLALIAQTGEMGYPSVLTAPVWGFYDVSFKGQAFKFQRPYGSYVMENILFKISFPAEFHAQTAAEAAMQLHEQLALVGKTVEDIARITIRTHEAAIRIIDKKGPLHNPADRDHCIQYMVAVPLIFGRLTAEDYEDIIAQDPRIDILRDKMSCQEDPQFTADYHDPQKRAIANALTIEMKDGTVLPEVYVPYPIGHPRRREEGIPKLIEKYKRNLARIFSEKQQKQIIQSTLDYDTFVALDVQQLVDLMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT33</accession>
    <name>D7VT33_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996007.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14137"/>
    <dbReference type="EnsemblBacteria" id="EFK56934">
        <property type="protein sequence ID" value="EFK56934"/>
        <property type="gene ID" value="HMPREF0766_14137"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZCDF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1802666_0_0_10"/>
    <dbReference type="OrthoDB" id="1439160at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="144" mass="16689" checksum="02EB45C3D9201FAB" modified="2010-10-05" version="1">MKQLLDLDAFAKTLTDKGYDGYFQTEAAYADKIKDSISRFLEACKNGMDKPMLPNIMMLTTYLQWNGDDKPKVECNMWVKYEDGLFDVQKMNIERIDQYGQLLKQSKLTDLSTSSVPTRKEAIAQVSDKPKEQLSSPKRRFKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT83</accession>
    <name>D7VT83_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_14187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996115.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14187"/>
    <dbReference type="EnsemblBacteria" id="EFK56984">
        <property type="protein sequence ID" value="EFK56984"/>
        <property type="gene ID" value="HMPREF0766_14187"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_4_0_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="43"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="129"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="200" mass="23574" checksum="BEC03DA7196ACAEC" modified="2010-10-05" version="1">MELNSMVDVASLSEEQLVALLRDSRQHAFNEIYKRHWTGIFLSAKNRLANEEDAYEIVQNIFLNLWRKRSSFELTKNFAVYFATATKYEILKSLSRQGHLELHRNILRTSISERDDSTVNELETKELLESLEQSIRVLPEKCQLVFRLRVEKEYSQKEIAKELNISEKTVEAHLTKARKHIRNDLGILAFVHLIHYLKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTE7</accession>
    <name>D7VTE7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996296.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57048">
        <property type="protein sequence ID" value="EFK57048"/>
        <property type="gene ID" value="HMPREF0766_14251"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503414W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1554309_0_0_10"/>
    <dbReference type="OrthoDB" id="2145155at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="172" mass="19961" checksum="D9768BEE3CA82C39" modified="2010-10-05" version="1">MKGLQQQKSQLLIYDYMVRKSNTVNGTVFVNSYVKTEMTFTPYFLLLFNLSFIPHSNNHIQQKQDIQKKWKIVSEEITYLNPDHSKNEGLRGRTDYSRSEKDTIHFLPDGKFNSVDGNGSYTLSGDSIHMNIGDQKSSFAYQISDSTLIMRQDYKTPSYLKRVTLNLKVLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTM5</accession>
    <name>D7VTM5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 14">Catalase</fullName>
            <ecNumber evidence="3 10 14">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">katE2</name>
        <name evidence="16" type="ORF">HMPREF0766_14345</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the catalase family. HPII subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 14"/>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14345"/>
    <dbReference type="EnsemblBacteria" id="EFK55784">
        <property type="protein sequence ID" value="EFK55784"/>
        <property type="gene ID" value="HMPREF0766_14345"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_3_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="PTHR42821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 14" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 14" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="15">
        <location>
            <begin position="85"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFK55784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="766" mass="86919" checksum="84B3C0FE0E22DCBF" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGA0</accession>
    <name>D7VGA0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, group 2 family protein</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001860.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10019"/>
    <dbReference type="EnsemblBacteria" id="EFK60075">
        <property type="protein sequence ID" value="EFK60075"/>
        <property type="gene ID" value="HMPREF0766_10019"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_0_0_10"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK60075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="316" mass="35851" checksum="56ECA734B260AD3D" modified="2010-10-05" version="1">MDISVVVPLFNEEESLPELTAWIDRVMQANNFSYEIILVDDGSNDSSWKVIERLKEGSDNIIGVKFRRNYGKSAALNVGFAAAQGDVVITMDADLQDSPDEIPELYDRIMRQDADLVSGWKQKRYDPLTKTVPTKLFNAVTRKMSGIDNLHDFNCGLKAYKKDVVKSIEVYGEMHRYIPVLAKWAGFSAIQEQVVQHYPRKYGTTKFGPGRFVKGFLDLLSIYFVGKFGKRPMHFFGSIGVISFLIGIFITFYLIVDKLMSIANHSPYRNVTDQPLFFLSLVAILIGTQLFLTGFVAELVSRNGSERNKYQIDRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGD6</accession>
    <name>D7VGD6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_10055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0187 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10055"/>
    <dbReference type="EnsemblBacteria" id="EFK60111">
        <property type="protein sequence ID" value="EFK60111"/>
        <property type="gene ID" value="HMPREF0766_10055"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029790_4_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin/UPF0187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="UPF0187"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="PTHR33281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK60111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="356" mass="41476" checksum="6DA6363474ECFB78" modified="2010-10-05" version="1">MKYFIFEYTSHLKFMIVRKTLSLTAIFRFAGHHLWWLITYMVLVSILYKVAGWHWISIPWLPVSLVGTALAFYIGFKNNQSYDRVWEARKIWGAIVNSSRSWGTMVNAFVCNSADTQFTSNEINQLKKHLIYRHIAWLYTLREQLLVPTQWEHVSLRGHFGKIARKRQELEGVGLYRDYLNETQKQNYFFDDQELRTAANKATQLINLQSQQLAALEEQAVLHMRKQLDLQKVLSDFYDHQGRAERIKKFPIPRQYANLSFIFNCIFILLLPLGIVAEFSKLGDAGVWLMIPFGTIVGWIYVLMELIGDYSENPFEGLGTDIPMLSICRTIEIDLLQMLGETDIPKPIQPVKDVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGH3</accession>
    <name>D7VGH3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002042.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10092"/>
    <dbReference type="EnsemblBacteria" id="EFK60148">
        <property type="protein sequence ID" value="EFK60148"/>
        <property type="gene ID" value="HMPREF0766_10092"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147365_1_0_10"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="139" mass="16245" checksum="C17091C3CF090468" modified="2010-10-05" version="1">MTDTIHPNHKIHQGRNVKRFREMLGIKQDALAYELGEDWNQQKVSLLEQKETIEAQLLQQISAVLKIPVEAIQNFDEEKAIVNIQNNYEGSNPGVTNVAGYQYNNECTFNPLDKMVELYERMLQQQKEMIDRLEKLIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGI5</accession>
    <name>D7VGI5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HMPREF0766_10104</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002064.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10104"/>
    <dbReference type="EnsemblBacteria" id="EFK60160">
        <property type="protein sequence ID" value="EFK60160"/>
        <property type="gene ID" value="HMPREF0766_10104"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_0_10"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="280"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK60160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="439" mass="49179" checksum="05F8923BEABDECD2" modified="2010-10-05" version="1">MLTEIIVILILILLNGILSASEIAIVSSRKARLQAESDKKNPAAKIALDLKEHPNQFLSTVQIGITLIGILTGFFSGGTISTFIDAQLEQISFFAPYSQQLSVILVVIIITYLSLVIGELVPKRIGMAIPERYATLIAFPMHFLSKIMKPFVWFLSISTDFLVRLLNIKVSKNAVTEEEIKALVDEGVDSGIIDNIEHDIVDRLLSIGDKKAINLMVHRSKIDYLDLQDSFEENKKVITATQHTVYPICDGNFDKIKGVVHVKTLLQQYLNNEETDLSALITPIPYINENSGALSVLESFRNSKAAQAIVIDEYGIPQGIITLKDILTGLVGDFDDLNNIENSKIRKREDGSFLIDGRYQLDDFMENLEVGLSEKDEEEIRNITTVAGLVFFLLDRVPEEGDKVIYKNLEFEVLDMDGNRIDKLLVTRLPLSSDQDYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH32</accession>
    <name>D7VH32_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase M16 inactive domain protein</fullName>
            <ecNumber evidence="6">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_10301</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997125.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10301"/>
    <dbReference type="EnsemblBacteria" id="EFK59384">
        <property type="protein sequence ID" value="EFK59384"/>
        <property type="gene ID" value="HMPREF0766_10301"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_306466_0_0_10"/>
    <dbReference type="OrthoDB" id="1188251at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106892" evidence="3">
        <location>
            <begin position="24"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="4">
        <location>
            <begin position="66"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="5">
        <location>
            <begin position="265"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="5">
        <location>
            <begin position="784"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK59384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="980" mass="110453" checksum="C286AE01A87DE71C" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH54</accession>
    <name>D7VH54_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="8">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">hisA</name>
        <name evidence="10" type="ORF">HMPREF0766_10323</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8 9">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997169.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10323"/>
    <dbReference type="EnsemblBacteria" id="EFK59406">
        <property type="protein sequence ID" value="EFK59406"/>
        <property type="gene ID" value="HMPREF0766_10323"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_1_2_10"/>
    <dbReference type="OrthoDB" id="794219at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="Isoase_HisA-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK59406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="250" mass="28246" checksum="C7031EC89D126898" modified="2010-10-05" version="1">MYIIPAIDVLDKKVVRLREGNYDDVTTYDISLEEQIDRYHANGTELVHIIDLNGAKGDFSNQEYLFNIIRKTEMKIQYGGGVRSIEKVKELIDAGVYRVIVGTQAITNPEFLEELSTLNEGKIKYADHIVIAIDVLDEVIKYSGWLESSPIKLIEYIDKCLALGFYRFLCTDISKDGKLGGAGVELYKKLLDHSPIIKLIGSGGISSMDDIRKLQELGRMESCVVGKAIYENRISIEEIQDWNLKSLISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH99</accession>
    <name>D7VH99_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin_Reduct domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997262.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10368"/>
    <dbReference type="EnsemblBacteria" id="EFK59451">
        <property type="protein sequence ID" value="EFK59451"/>
        <property type="gene ID" value="HMPREF0766_10368"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059021_3_1_10"/>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="24"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="301" mass="33562" checksum="52E542309C91009E" modified="2010-10-05" version="1">MSDIKTKVIDPIQQQAIFDNLIKYAIAPRPICFASTVDLAGQVNLSPFSYFNLMSHQPPVCVFSPLRRMRDGTTKHTLENIKEVKEVVINIVNYDMVQQQSLASTEYAKGINEFEKSGFTAMPSTYVRPPRVAESPVQLECKVKDIIALSDDPGAGNLVLAEVVCMHIHEDLLDSNNQVDQAKLDLVARLGGDWYCRVTEESLFKVPKPLRNLGIGIDQLPESIRFSTVLTGNHLGMLANVEVLPEFSPTGSTSPDQKTLSSLEKWKDDPVRFQKELHTQAAKLLDTGELQKAWQLLLLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHE7</accession>
    <name>D7VHE7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_10416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997387.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10416"/>
    <dbReference type="EnsemblBacteria" id="EFK59499">
        <property type="protein sequence ID" value="EFK59499"/>
        <property type="gene ID" value="HMPREF0766_10416"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048072_2_2_10"/>
    <dbReference type="OrthoDB" id="1808868at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="304" mass="34555" checksum="B24CC58BD1ED823B" modified="2010-10-05" version="1">MNKKKYWNILKNILKVVVTIGALYWVFSKVDIKDLVEAIRNSNPLFLFLAFLAFLLSIFISSSRLLSFLKGIGLDVSEKYNFKLYQLGLFYNLFLPGGIGGDGYKIYFLRKKFKIKGRKLLSALFFDRLSGLWALCLIISALIMFMPQLKIPNALTAACFISGTIVYYLVIWKFFPDFKPRFFRTHIKAIGVQSMQVVSAIMILYALGFEGKFSPYLFLFLASSLVAIIPFSVGGLGMREIVYMWGAKIFYLDSHLAVLISLLFYIISALVSVSGAYYVFNPKGLGEEKLPSPEEVEQSRIEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHF7</accession>
    <name>D7VHF7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="11 14">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">ruvC</name>
        <name evidence="15" type="ORF">HMPREF0766_10426</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 14">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the RuvC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="11 14"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997414.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10426"/>
    <dbReference type="EnsemblBacteria" id="EFK59509">
        <property type="protein sequence ID" value="EFK59509"/>
        <property type="gene ID" value="HMPREF0766_10426"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0817">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091257_3_0_10"/>
    <dbReference type="OrthoDB" id="1815080at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020563">
        <property type="entry name" value="X-over_junc_endoDNase_Mg_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00228">
        <property type="entry name" value="ruvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01321">
        <property type="entry name" value="RUVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFK59509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="189" mass="20715" checksum="6642A043A50B3937" modified="2010-10-05" version="1">MQKEKAKERIILGIDPGTVVLGYGLVKETGKKISLISLGVIKMGHLDDHALKLQRIFKKTSALIEEYKPDCVALEAPFYGKNIQVMLKLGRAQGVAMAAALNHDIPIFEYSPRKIKQSVTGNGNATKEQVAAMLKTLLSFNETPEFLDATDGLAVAVCHSFQQNTSSSGTSKSYSGWEAFIKDNEKRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHG0</accession>
    <name>D7VHG0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase dimerization domain protein</fullName>
            <ecNumber evidence="3">3.5.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">argE</name>
        <name evidence="3" type="ORF">HMPREF0766_10429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.16" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997424.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10429"/>
    <dbReference type="EnsemblBacteria" id="EFK59512">
        <property type="protein sequence ID" value="EFK59512"/>
        <property type="gene ID" value="HMPREF0766_10429"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_2_0_10"/>
    <dbReference type="OrthoDB" id="906744at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008777">
        <property type="term" value="F:acetylornithine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="170"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="355" mass="39437" checksum="E13AC6ADC662BDFF" modified="2010-10-05" version="1">MSNMLTLIDKSITLLQELIRIPSLSREEADTAHHIQRYLESYAVKTHRKGNNIWAYNRFYDAAKPTILLNSHHDTVKPNPGYSRDPFQAEIIDDKLFGLGSNDAGGCLVSLIAVFLYYHEQKDLRYNFCLAATAEEEISGLNGISAIVDDLGRLDFAIVGEPTLMDLAITEKGLMVLDCESQGVAGHAAREEGVNAIYEAMPDIEWFRTFRFPKESESLGPVKMSVTQINAGSQHNVVPSTCSFVVDVRTTDAYSNEETLAIIQQHVRSSVKARSTRLTSSFIPKDHPVVKAGTALGRNTYGSPTMSDQALLRIPSLKLGPGDSARSHMADEYIYVYEIEQGIPLYIQILDQIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHI3</accession>
    <name>D7VHI3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rpsQ</name>
        <name evidence="6" type="ORF">HMPREF0766_10452</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997486.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10452"/>
    <dbReference type="EnsemblBacteria" id="EFK59535">
        <property type="protein sequence ID" value="EFK59535"/>
        <property type="gene ID" value="HMPREF0766_10452"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_1_0_10"/>
    <dbReference type="OrthoDB" id="2035880at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK59535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="84" mass="9767" checksum="C771B9DB5B078D37" modified="2010-10-05" version="1">MERKLRKTRIGLVVSNKMDKSIVVAVERKVKHPIYGKFVKKTTKFKAHDEENTCGIGDTVLIMETRPLSKTKNWRLVEILERAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHM5</accession>
    <name>D7VHM5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Indole-3-glycerol phosphate synthase</fullName>
            <shortName evidence="8">IGPS</shortName>
            <ecNumber evidence="8">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">trpC</name>
        <name evidence="10" type="ORF">HMPREF0766_10494</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TrpC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997563.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10494"/>
    <dbReference type="EnsemblBacteria" id="EFK59577">
        <property type="protein sequence ID" value="EFK59577"/>
        <property type="gene ID" value="HMPREF0766_10494"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034247_2_0_10"/>
    <dbReference type="OrthoDB" id="1789381at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="9">
        <location>
            <begin position="4"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK59577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="260" mass="28795" checksum="52A17FAB123F4225" modified="2010-10-05" version="1">MTILDKIVERKKTEVAEAKTKVPLEKLENYPLFRRSCYVLRDSILHPERTGIIAEYKRASPSKGLINGVSSVTEVVSGYQAAGASAISVLTDTDFFKGTLDDLTEARKALTIPLLRKEFIVDKYQIAEAKAYGADIILLIAACLTAGEILDFSAYAKQLGLNVLLEVHDQEELNRSLFDTIDAIGVNNRNLKDFSVSLDHSYDLVNKIPSQYIKVSESGISDPETIKNLKKAGFQAFLIGENFMKTENPSVAISNFVKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHN2</accession>
    <name>D7VHN2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997577.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10501"/>
    <dbReference type="EnsemblBacteria" id="EFK59584">
        <property type="protein sequence ID" value="EFK59584"/>
        <property type="gene ID" value="HMPREF0766_10501"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017617_1_0_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041700">
        <property type="entry name" value="OMP_b-brl_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14905">
        <property type="entry name" value="OMP_b-brl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMP_b-brl_3" evidence="1">
        <location>
            <begin position="405"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="832" mass="94416" checksum="3A628EE90F22CC60" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI35</accession>
    <name>D7VI35_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ybeY</name>
        <name evidence="8" type="ORF">HMPREF0766_10654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997940.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10654"/>
    <dbReference type="EnsemblBacteria" id="EFK59737">
        <property type="protein sequence ID" value="EFK59737"/>
        <property type="gene ID" value="HMPREF0766_10654"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106710_3_3_10"/>
    <dbReference type="OrthoDB" id="1830156at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="142" mass="16815" checksum="6D2DF5521171E4A2" modified="2010-10-05" version="1">MKNINFFAEDTDFKPKEKQKIRQWIADTIKSEGFKRVGELNFIFSSDAYLLEINKQYLNHDTFTDIVTFDSSEEEDTIAGDIFISIERIQDNAEKFKVAERDELHRVVIHGVLHLCGYHDKKAEDKKRMTEKEDEYLSKRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI38</accession>
    <name>D7VI38_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997946.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10657"/>
    <dbReference type="EnsemblBacteria" id="EFK59740">
        <property type="protein sequence ID" value="EFK59740"/>
        <property type="gene ID" value="HMPREF0766_10657"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141662_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107158" evidence="1">
        <location>
            <begin position="22"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="157" mass="16996" checksum="2192624D28BEA81A" modified="2010-10-05" version="1">MKKNLLSFLILMFLGSATVQAQGFLDKLDRALDKVTKASNSAEKAASAAGKVKNSGNSLLQKSNTETNGDLNKTTINIVGTDMATLRKLNAAIETCDIVTDAKLKYSSKKSSIEVFHNGSTDELLEAILKKETGIFTDKNIEDLKDGTIQVNLMPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI99</accession>
    <name>D7VI99_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase, AAA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ycaJ</name>
        <name evidence="3" type="ORF">HMPREF0766_10718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10718"/>
    <dbReference type="EnsemblBacteria" id="EFK59801">
        <property type="protein sequence ID" value="EFK59801"/>
        <property type="gene ID" value="HMPREF0766_10718"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017985_0_3_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="53"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="439" mass="48991" checksum="A9AA3FC64F61E390" modified="2010-10-05" version="1">MKVHEKSAKFVIIMATRIPLAERMRPRNIVGYVGQEHIVGEGAVLRNALEQNNIPSMILWGPPGVGKTTLALLMAKALDRPFFSLSAIQSGVKDIREVIEKADQLQKFNQEQPILFIDEIHRFSKSQQDSLLGAVERGLVTLIGATTENPSFEVISALLSRCQVYVLKHLTEEELIGIVNSAISEDEFLKEEKIEVKEYEALLRLSGGDARKLLNVLELVVNASLSLNKPITNEFVLKQVQQNMAIYDKTGEQHYDIISAFIKSIRGSDPNAAVYWLARMIEGGEDPSFIARRLLILASEDIGNANPNALLLANNCFQAVNVIGWPESRIILSQTVTYLASSAKSNASYEAINKAQALVKQTGDLSVPLHLRNAPTKLMKELNYGTEYKYSHAFPGNFVDQEFMPDKISGTLLYDPGKNAAEEKLRQSLKEKWKNKYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIB6</accession>
    <name>D7VIB6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsfS</name>
        <name evidence="3" type="ORF">HMPREF0766_10735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998101.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10735"/>
    <dbReference type="EnsemblBacteria" id="EFK59818">
        <property type="protein sequence ID" value="EFK59818"/>
        <property type="gene ID" value="HMPREF0766_10735"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092688_2_2_10"/>
    <dbReference type="OrthoDB" id="1990650at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="124" mass="13946" checksum="D8C8CF25C74495E4" modified="2010-10-05" version="1">MVKNKNAGLSSKLAEIAVHGMQEKKGNEIVRLDLRNINSSVSDYFVICHADSTTQVNAIAKSVEEEIFKAFGQDPWHKEGHGNGEWILIDFVDVVVHIFKTEKRSHYGIEDLWGDADVKTYQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIE3</accession>
    <name>D7VIE3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998154.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10762"/>
    <dbReference type="EnsemblBacteria" id="EFK59845">
        <property type="protein sequence ID" value="EFK59845"/>
        <property type="gene ID" value="HMPREF0766_10762"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZMFB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2755822_0_0_10"/>
    <dbReference type="OrthoDB" id="2206097at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107266" evidence="2">
        <location>
            <begin position="21"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="70" mass="7474" checksum="2708A4E6CF306066" modified="2010-10-05" version="1">MKNTKLMLMFAAGCMLSVAACGNSKTDNSGQSTTVPPTNGEDTRYNQNQADSLVMPIDSNVTDTSNTDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIN2</accession>
    <name>D7VIN2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998330.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10851"/>
    <dbReference type="EnsemblBacteria" id="EFK59934">
        <property type="protein sequence ID" value="EFK59934"/>
        <property type="gene ID" value="HMPREF0766_10851"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028014_2_1_10"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="424" mass="49168" checksum="A3231C506BAA4013" modified="2010-10-05" version="1">MLKKINHRLKIGLTLDFMQQQNVLIIGLVWPEPTSSAAGFRMRQLIELFLQHDLQVVFACAAQKSAYSLDLAAMGVEEAPILLNDPSFDTFIQELNPAMVVFDRFMIEEQYGWRVTQHCQDALKILDTEDLHFLRHARQQNTTDAAPDLYNDVTKRELAAILRSDISLIISETEMDLLTSTFRIDPDILYYLPFLEQEIDHERAASWKTFEERKDMMFIGNFLHEPNWHTVLNLKKNIWPLLRKKMPEASLYIYGAYPSQKVLQLHNPKERFFIAGRAEDARETMAKHRLLIAPIPFGAGIKGKFIDAMQTGTPSVTSSLGAESMADRVNWPGAVEDDVNLFTEQATILYRDREIWNEAQKKGISIINNRYSRRKFAETFIQRLFELQRAIALHRQTHFVGQILQHHTLQSTKYMSLWITEKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIX1</accession>
    <name>D7VIX1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD dependent epimerase/dehydratase family protein</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yraR</name>
        <name evidence="2" type="ORF">HMPREF0766_10940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998517.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10940"/>
    <dbReference type="EnsemblBacteria" id="EFK60023">
        <property type="protein sequence ID" value="EFK60023"/>
        <property type="gene ID" value="HMPREF0766_10940"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071330_2_0_10"/>
    <dbReference type="OrthoDB" id="948454at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="221" mass="24616" checksum="33C318F01F84BFCF" modified="2010-10-05" version="1">MDKTGYTALVLGSTGLIGSFLVEMLLDNTQYSTVYAVSRSPLQLQHPGFINIVADADSIAHHLENIAVDHLYCCLGSTKSKTPDLSAYYKIDHDYPLSVTQQLKNKVLSAVCLVSSMGANVLSNNFYLKMKGEVERDIESLSIERTFIFRPSLLLGKRKENRLLEKVSSVVMNIINYFLIGKLKDYKSIKAADVARSMMHVCLSDMTGTHIFKTAKIKELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIZ6</accession>
    <name>D7VIZ6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter, SSS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yidK</name>
        <name evidence="9" type="ORF">HMPREF0766_10965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998562.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10965"/>
    <dbReference type="EnsemblBacteria" id="EFK60048">
        <property type="protein sequence ID" value="EFK60048"/>
        <property type="gene ID" value="HMPREF0766_10965"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018808_11_4_10"/>
    <dbReference type="OrthoDB" id="231452at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="513"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="322"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK60048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="567" mass="62760" checksum="3417720AAED4C618" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ59</accession>
    <name>D7VJ59_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 8-amino-7-oxononanoate synthase</fullName>
            <ecNumber evidence="4">2.3.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bioF</name>
        <name evidence="4" type="ORF">HMPREF0766_11028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.29" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000371.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11028"/>
    <dbReference type="EnsemblBacteria" id="EFK58912">
        <property type="protein sequence ID" value="EFK58912"/>
        <property type="gene ID" value="HMPREF0766_11028"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_11_0_10"/>
    <dbReference type="OrthoDB" id="479874at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008890">
        <property type="term" value="F:glycine C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="46"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="399" mass="43929" checksum="1C95E59948E20ADF" modified="2010-10-05" version="1">MSKGKLSERISHFNIVEELKSKGLYAYFRPIQSKQDTEVMIDGKRVLMFGSNSYLGLTIDPRIIEAAQDALSKYGTGCAGSRFLNGTLDIHIELEHKLSQLVGKEASILFSTGFQSNLGPISCLMGRNDYILLDERDHASIIDGSRLSFSKVIKYGHNDMDDLRAKLSRLPSESAKLIVTDGIFSMEGDIVNLPEMVKIADEYDAALMVDDAHSLGVIGEHGAGTASHFGLTDKVDLIMGTFSKSLASLGGFVAGDADVIDYLKHNARSVMFSASMTPASVASTLKALEIMISEPEHMENLWKNTNYAKQQLLESGFDLGATESPILPIFIRNNEKTFWVTKMLQDDGVFVNPVVSPAVPSEESLIRFSLMATHTFDQIDEAVEKMVRVFKQAEIESLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJA1</accession>
    <name>D7VJA1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000495.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11070"/>
    <dbReference type="EnsemblBacteria" id="EFK58954">
        <property type="protein sequence ID" value="EFK58954"/>
        <property type="gene ID" value="HMPREF0766_11070"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033Y4H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1414382_0_0_10"/>
    <dbReference type="OrthoDB" id="1909426at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="192" mass="22677" checksum="0DE7A7CF515CE17A" modified="2010-10-05" version="1">MKVSEFEDNLKTIHQTLSSIRLNEDRNTAGTYVDVLYSFNSALPENSYPFLAYLEDTIDSIEFSIYGRNADLFMLRKNELESDKDPIPYIKGKREWESYEFTLSTLLLTEYTDWLSEQAEYKFELQLPGYGIYVPVKKYWNQFFNPFSYPNKIWLGKDHKSVLYIQNESNMLKCVANNAEDLRFAEEVLCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJD3</accession>
    <name>D7VJD3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000588.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK58986">
        <property type="protein sequence ID" value="EFK58986"/>
        <property type="gene ID" value="HMPREF0766_11102"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033I45">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1853941_0_0_10"/>
    <dbReference type="OrthoDB" id="2102601at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="132" mass="15521" checksum="C314967A283853EC" modified="2010-10-05" version="1">MEQLFPLLIGLAVFAYKIYENFNKQKKEAEQRMRQQKRPVQQQHKPQPVPATPPHPPVVKKEKYSTMSHQKVVRESNEVPAEVLKLREERERLKSDKKIQVPIPVSASKEEKVVFDLRQAVIQQAILERPYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJE6</accession>
    <name>D7VJE6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000602.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11115"/>
    <dbReference type="EnsemblBacteria" id="EFK58999">
        <property type="protein sequence ID" value="EFK58999"/>
        <property type="gene ID" value="HMPREF0766_11115"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZZB9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108362_1_0_10"/>
    <dbReference type="OrthoDB" id="1719611at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024047">
        <property type="entry name" value="MM3350-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012912">
        <property type="entry name" value="Plasmid_pRiA4b_Orf3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07929">
        <property type="entry name" value="PRiA4_ORF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159941">
        <property type="entry name" value="SSF159941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="193" mass="22540" checksum="0E327BD2FE42F817" modified="2010-10-05" version="1">MAIYRFRVTFEDYEDVYREIDMLSKQSFLDLHDAIHKTTNYETEVSSSFYVSNDQWKKGTEIALLPSERKISTDVLLMENIRLSKFIDDPHQKFYYIYNFDRPYDFHVELIKILKEEDGKEYPVVFKTVGAAPKPLGAFAAPTTPLDEDDDTADYEEETQYGVDEEDDYDMFDDEESEDGGEEKGSTGVEDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJI6</accession>
    <name>D7VJI6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000667.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11155"/>
    <dbReference type="EnsemblBacteria" id="EFK59039">
        <property type="protein sequence ID" value="EFK59039"/>
        <property type="gene ID" value="HMPREF0766_11155"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_4_1_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014327">
        <property type="entry name" value="RNA_pol_sigma70_bacteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02985">
        <property type="entry name" value="Sig70_bacteroi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="31"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="132"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="205" mass="24443" checksum="BB227DFCCA6FAFC8" modified="2010-10-05" version="1">MLNLKITSLDNEHTLLVAISNGDHKSFETLFLHYYKPFGNYVFKLLEDISLTEDVLQEVFLRIWTDRENLHTITNFKDYLFIITRNRVYNLLNEKSRKSVLFESLDEKANFKQIPQEEEEQKADLELYYTLLEQEIDNLPLQQQKIFRLSKLKKMKYEEIARMLDISVETVRKHMYLANQTLKTRLKGKEGGILLVILSAVYQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJQ7</accession>
    <name>D7VJQ7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Imidazolonepropionase</fullName>
            <ecNumber evidence="2">3.5.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hutI</name>
        <name evidence="6" type="ORF">HMPREF0766_11226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000829.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11226"/>
    <dbReference type="EnsemblBacteria" id="EFK59110">
        <property type="protein sequence ID" value="EFK59110"/>
        <property type="gene ID" value="HMPREF0766_11226"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041647_0_1_10"/>
    <dbReference type="OrthoDB" id="785930at2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="PTHR42752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01224">
        <property type="entry name" value="hutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="5">
        <location>
            <begin position="123"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK59110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="419" mass="45166" checksum="6508DE6A90EEAD92" modified="2010-10-05" version="1">MNNENQYRLTGPFREVLTMTDLPLKGALQDQQLHIEKNAGILIKGDRIERIADFELLRSESSYPDLQLTLVEEDTVVIPGMIDVHTHIAFAGTRANDFALRNAGSSYLEIAESGGGIWSTVKDTRAATTDDLVHLILERAAALIRQGITTIEVKSGYGLNVEEELKILRAIKLAAKTCKAKLISTCLAAHTLPKDFEGSHEAYLEILVKELFPVLKEEQLSNRIDAFVEKSAFSKEQIKPYFEAARALGFDITVHADQFSTSGSEVAVSFAARSADHLESSGSAEIELLAASDVIPVALPGASMGIGCAFTPARRLLDAGASLAIATDWNPGSAPMGHLLTQASVLACFEKLSNAEVFAGVTYRAAAALGLSDRGLLSKGAKADFVLFPTDSIKEITYHQGLLAPAQVWIDGAVVFDHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJR0</accession>
    <name>D7VJR0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11229"/>
    <dbReference type="EnsemblBacteria" id="EFK59113">
        <property type="protein sequence ID" value="EFK59113"/>
        <property type="gene ID" value="HMPREF0766_11229"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031879_0_0_10"/>
    <dbReference type="OrthoDB" id="324607at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035423">
        <property type="entry name" value="M60-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042279">
        <property type="entry name" value="Pep_M60_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031161">
        <property type="entry name" value="Peptidase_M60_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17291">
        <property type="entry name" value="M60-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13402">
        <property type="entry name" value="Peptidase_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01276">
        <property type="entry name" value="M60-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51723">
        <property type="entry name" value="PEPTIDASE_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107582" description="Peptidase M60 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M60" evidence="2">
        <location>
            <begin position="92"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="601" mass="68284" checksum="6B673DE4926791CC" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJR4</accession>
    <name>D7VJR4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000850.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11233"/>
    <dbReference type="EnsemblBacteria" id="EFK59117">
        <property type="protein sequence ID" value="EFK59117"/>
        <property type="gene ID" value="HMPREF0766_11233"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033NUP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_939777_0_0_10"/>
    <dbReference type="OrthoDB" id="1375638at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="296" mass="33057" checksum="71127EA52B9885AD" modified="2010-10-05" version="1">MGKRCGTKILRLGFGQIHRSCVAFGICCTFYVKKPTNMKIIQNLFVACLFLLLLSCEKSEEKQSSAEPVTISLMERADGSAKTLHLINKTVKIFNCGNYYLNSDFKLQNGTIVLNYYDVKSPDVCLTSLGPAISQFDLVNLENKSYPVEVNLGGEQIKGKLEVTANDYTLTLPEQQMVKVLYPKLNRVPAHIIFGFARSTKEKAAIVDQFLTELQNKGAVAVQLPSGKYTMFDVDNSGKVMMDLSAYNLAKPFALTYRGDVETLKTLVKSYKTTHGTDFDTEIHFSDGTEIYSFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJT4</accession>
    <name>D7VJT4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbamoyl-phosphate synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="5">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">carB</name>
        <name evidence="10" type="ORF">HMPREF0766_11253</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000913.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11253"/>
    <dbReference type="EnsemblBacteria" id="EFK59137">
        <property type="protein sequence ID" value="EFK59137"/>
        <property type="gene ID" value="HMPREF0766_11253"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0458">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000513_1_0_10"/>
    <dbReference type="OrthoDB" id="48855at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="133"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="676"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK59137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="938" mass="104085" checksum="143CED4541FD2C13" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJU6</accession>
    <name>D7VJU6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11265"/>
    <dbReference type="EnsemblBacteria" id="EFK58548">
        <property type="protein sequence ID" value="EFK58548"/>
        <property type="gene ID" value="HMPREF0766_11265"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152554_2_0_10"/>
    <dbReference type="OrthoDB" id="2086461at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010862">
        <property type="entry name" value="DUF1493"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07377">
        <property type="entry name" value="DUF1493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="105" mass="12441" checksum="C4A5FF4ACB93D65B" modified="2010-10-05" version="1">MVQIMDTRLIDLLQEYNSTDKALDENVRLYHDLNIYGDDAIELLNCFEEQFKVDLSRFCFTDYFPSEGDWILPSLFRFLTGKKPKEYKQLTLSDLNKAINISYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJU8</accession>
    <name>D7VJU8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11267"/>
    <dbReference type="EnsemblBacteria" id="EFK58550">
        <property type="protein sequence ID" value="EFK58550"/>
        <property type="gene ID" value="HMPREF0766_11267"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150514_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="124" mass="14603" checksum="34439A8CE4D71A0A" modified="2010-10-05" version="1">MNDFIKWEPIITPIPKDLYFVCLSDSKGILTIRLAEMEDNKVLEFKIKGVMAYRVVDEGARLKTLYENPSYRRFVASDNSSYLKWFHMESREMFEDWGLKHYSIGNINNIIDIICGSDIVVKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK15</accession>
    <name>D7VK15_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-70 region 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998834.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11334"/>
    <dbReference type="EnsemblBacteria" id="EFK58617">
        <property type="protein sequence ID" value="EFK58617"/>
        <property type="gene ID" value="HMPREF0766_11334"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_4_1_10"/>
    <dbReference type="OrthoDB" id="1992113at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="126"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="181" mass="21409" checksum="4CECB4747BA3A61D" modified="2010-10-05" version="1">MNTWSDKELFDVIKNNNTQAFSILFDRYSDILFRFILKRTHSVTDTEDILQEVFLSLWNKRTKIEVGDSIYPYLFKAARYEVIDWMVKSEKRVKHFEQLQVKAEKDIICLHNTEDKLMAQELAKLLEDEVQKMPFTMRSIFNLSRGEDMCIKDIASQLSISEQTVKNNISMAMSRLRILVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKD0</accession>
    <name>D7VKD0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas9</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">csn1</name>
        <name evidence="8" type="synonym">cas9</name>
        <name evidence="11" type="ORF">HMPREF0766_11449</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer; Cas9 is inactive in the absence of the 2 guide RNAs (gRNA). Cas9 recognizes the protospacer adjacent motif (PAM) in the CRISPR repeat sequences to help distinguish self versus nonself, as targets within the bacterial CRISPR locus do not have PAMs. PAM recognition is also required for catalytic activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer. Binds crRNA and tracrRNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Has 2 endonuclease domains. The discontinuous RuvC-like domain cleaves the target DNA noncomplementary to crRNA while the HNH nuclease domain cleaves the target DNA complementary to crRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated Cas9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999145.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11449"/>
    <dbReference type="EnsemblBacteria" id="EFK58732">
        <property type="protein sequence ID" value="EFK58732"/>
        <property type="gene ID" value="HMPREF0766_11449"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004928_0_0_10"/>
    <dbReference type="OrthoDB" id="24005at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01480">
        <property type="entry name" value="Cas9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028629">
        <property type="entry name" value="Cas9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032239">
        <property type="entry name" value="Cas9-BH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033114">
        <property type="entry name" value="HNH_CAS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041383">
        <property type="entry name" value="RuvC_III"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16593">
        <property type="entry name" value="Cas9-BH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13395">
        <property type="entry name" value="HNH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18541">
        <property type="entry name" value="RuvC_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51749">
        <property type="entry name" value="HNH_CAS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HNH Cas9-type" evidence="10">
        <location>
            <begin position="767"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="active site" description="For RuvC-like nuclease domain" evidence="8">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor for HNH nuclease domain" evidence="8">
        <location>
            <position position="848"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="726"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="730"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1045"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK58732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1426" mass="167495" checksum="F1CFC0A715A3C668" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKF5</accession>
    <name>D7VKF5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="11">5.4.2.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">glmM</name>
        <name evidence="11" type="ORF">HMPREF0766_11474</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="11"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999208.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11474"/>
    <dbReference type="EnsemblBacteria" id="EFK58757">
        <property type="protein sequence ID" value="EFK58757"/>
        <property type="gene ID" value="HMPREF0766_11474"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_7_1_10"/>
    <dbReference type="OrthoDB" id="256504at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024086">
        <property type="entry name" value="GlmM_arc-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03990">
        <property type="entry name" value="Arch_GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="8"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="169"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="269"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="394"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK58757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="460" mass="49634" checksum="89DD96F33B706122" modified="2010-10-05" version="1">MTLIKSISGIRGTIGGRAGEGLTPIDIVKFTAAFGKIIVKKSGNNKIVVGRDARISGEMVSNLVIGTLQSIGIDVIDLGLSTTPTVEIAVPKENAGGGIILTASHNPGQWNALKLLNDKGEFINDAEGKEVLSLGESLDFDFAEVGQLGKVEKNDSYLQKHIADVLALDLVDAEAVRNANFKVAVDAVNSTGGLFIPALLEALGVQTVYKIHCEPNGQFPHNPEPLKEHLTDLSKAVTENAADLGIAVDPDVDRLVFMMEDGELFGEEYTLVAVADYILQHTKGNTVSNLSSTRALRDVTVKHGGEYFAAAVGEVNVVTKMKEVNAVIGGEGNGGVIYPASHYGRDALVGVAIFLTHLARLGKKVSAYRAELPQYYMSKNKITLTPELDIDNLLAKMEEKYKHEDHSTIDGLKIDFANEWVHLRKSNTEPIIRIYSEGPTADAAEAIAQKIIREIEEIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKH7</accession>
    <name>D7VKH7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Redoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_11496</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999274.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11496"/>
    <dbReference type="EnsemblBacteria" id="EFK58779">
        <property type="protein sequence ID" value="EFK58779"/>
        <property type="gene ID" value="HMPREF0766_11496"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_1_1_10"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="289"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="429" mass="48774" checksum="2C0B8D7C2A7C6A22" modified="2010-10-05" version="1">MAQNATIINGTADKKAYAKVFLYKVLNGRLVEIATATPDSSERFAFKFTPEYQGLYAVGGSDALSLRHVFKFYFKGNDELNIRLEKANYSLSGNNSPENIALTDWFKASYSLLDKSVYWTTISTYMDFFPEVEEMYTQLDAIKSRNKTGNTKFDAFFPKIVDFDFANLAIGYLYTPRSAHPSKEELSDYYIQFKSDPFLSEDLLNFPYGDRFMTSLVYKKIDLASKPTFGQQVEAIPADVIKGQYVLARLTATRSYSEYQELYNQYKQYFILKEQQERAQAIAVKLADTKEGTQAVAFSYPDISGKKVSLADLKGKLVLIDLWATWCGPCKAEEPYWEKLNEQFKGKDIAFVGISVDQDKKAWDKYVPEKNLKGIQLHAGPGNDLSAAYKVTGIPRYMLIDKKGNIITTDSPRPSDPKLKLLIETWLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKN9</accession>
    <name>D7VKN9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YqeY-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999414.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11558"/>
    <dbReference type="EnsemblBacteria" id="EFK58841">
        <property type="protein sequence ID" value="EFK58841"/>
        <property type="gene ID" value="HMPREF0766_11558"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079430_2_0_10"/>
    <dbReference type="OrthoDB" id="1498741at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="PTHR28055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="149" mass="16570" checksum="1B1EA96703455099" modified="2010-10-05" version="1">MALEEKINQDIKAAMIAKDNAKLRGLRAIKAAILLAKTEKGGSEDLSEDTEIKVLQKLVKQRKESAEIYKTQNREDLYQIEVEEQNVIEEYLPKQLDRAEVESIIRQIIQETGASSVKDMGKVMGAANQKLAGQADGRTISEVVKSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL18</accession>
    <name>D7VL18_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-70 region 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11687</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999721.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11687"/>
    <dbReference type="EnsemblBacteria" id="EFK58291">
        <property type="protein sequence ID" value="EFK58291"/>
        <property type="gene ID" value="HMPREF0766_11687"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_9_3_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="119"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="178" mass="21454" checksum="CD6E92FCF7561E2E" modified="2010-10-05" version="1">MTERELLQQYRASGELDVLGKLYAPYMSLLYGVCFKYLNDADRSQDAVMQIFEELIDKLRIHQVDNFKSWLYTFSRNYCLMQLRKDKRVQQVDIEDHLAESEHFLDNSSDQLWDEVHFEKLETCMLTLNPEQERCIRLFYLEQKCYKDIVEETGYDMNKVKSYIQNGKRNLKICMEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL44</accession>
    <name>D7VL44_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4822 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11713"/>
    <dbReference type="EnsemblBacteria" id="EFK58317">
        <property type="protein sequence ID" value="EFK58317"/>
        <property type="gene ID" value="HMPREF0766_11713"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032VDI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139116_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032247">
        <property type="entry name" value="DUF4822"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16103">
        <property type="entry name" value="DUF4822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107363" description="DUF4822 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4822" evidence="2">
        <location>
            <begin position="39"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="163" mass="18055" checksum="CA266B7ABE6F1A1A" modified="2010-10-05" version="1">MIMRSLKNLGLIVLTLVSTTLLFSCSDDDKEVTPVLTPSEILASTAWETTGAKNNKGENVALTDANVAGAVGYAYYDIKGTFIIYDLKDVFRIQGDWSVSADGKTRTLVAKNPETQAVLFTRVVDILVLTPKEFTYRLYPNSSDRTVYYDIIHTPTTHAKPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLD9</accession>
    <name>D7VLD9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate etherase</fullName>
            <shortName evidence="3">MurNAc-6-P etherase</shortName>
            <ecNumber evidence="3">4.2.1.126</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">murQ</name>
        <name evidence="5" type="ORF">HMPREF0766_11809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:26410"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="EC" id="4.2.1.126"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-sugar metabolism; N-acetylmuramate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.126" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11809"/>
    <dbReference type="EnsemblBacteria" id="EFK58412">
        <property type="protein sequence ID" value="EFK58412"/>
        <property type="gene ID" value="HMPREF0766_11809"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049049_1_1_10"/>
    <dbReference type="UniPathway" id="UPA00342"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046348">
        <property type="term" value="P:amino sugar catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097173">
        <property type="term" value="P:N-acetylmuramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05007">
        <property type="entry name" value="SIS_Etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00068">
        <property type="entry name" value="MurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005488">
        <property type="entry name" value="Etherase_MurQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005486">
        <property type="entry name" value="Glucokinase_regulatory_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="PTHR10088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF5">
        <property type="entry name" value="PTHR10088:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00274">
        <property type="entry name" value="TIGR00274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01272">
        <property type="entry name" value="GCKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="4">
        <location>
            <begin position="54"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="273" mass="29303" checksum="D1FCFD0F841B4054" modified="2010-10-05" version="1">MIKMINTTEKESNYQDLDKMSVHELLTNINAEDKTVPLAVERAIPQIEKLVTATVEKMKTGGRLFYIGAGTSGRLGILDASECPPTFGVPFDWIIGLIAGGDTAIRKAVEFAEDDIEQAWKDLEEYGVNENDVVIGIAASGTTPYVIGGLTTANEKGLITGCIVCNGGSPIAAVAQLPVEVIVGPEFVTGSTRMKAGTAQKLVLNMLSTSIMIRLGRVKGNKMVDMQLSNHKLVARGVRIIMDETGADELTASELLEEFGNVRKAIENYVSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLF3</accession>
    <name>D7VLF3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAGPA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11823"/>
    <dbReference type="EnsemblBacteria" id="EFK58426">
        <property type="protein sequence ID" value="EFK58426"/>
        <property type="gene ID" value="HMPREF0766_11823"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4632">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_871267_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAGPA" evidence="1">
        <location>
            <begin position="129"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="319" mass="34456" checksum="3B456710748FDBE8" modified="2010-10-05" version="1">MFIVSAFTSCKQRDDWPVFEKKEVVVEKDTIPPDNQIGALTQSIISNTDIIKTFRLDSTTTVADGIVHTHIRYLNRLNRPVSMHVLEIDLSKPKLTAQALGPFNEVLYATQILPEMAKYNESGSGGKMMVAINGDAVLTSGTTINAPSGSYIRYGRQIKTNTTTTTAFTIPYFAVTKAGVPFIGNRPAATYPAEPVDLNTIYHLVSGTNWLVFNNNLITSTNATVSARTAIGINADKKVICVVVDGGDDAFSSGITLNDLGLVMKTLGSSRAFFTNGGNFSAVVKRQEDAKGPRWDMLNKPVNKTGSATANGIGFVLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLG4</accession>
    <name>D7VLG4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000103.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11834"/>
    <dbReference type="EnsemblBacteria" id="EFK58437">
        <property type="protein sequence ID" value="EFK58437"/>
        <property type="gene ID" value="HMPREF0766_11834"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033Q3V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1189302_0_0_10"/>
    <dbReference type="OrthoDB" id="1602621at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="233" mass="26807" checksum="3DC29EBADD1D9D08" modified="2010-10-05" version="1">MKIKAVSISILSILILTLMACKKEGESYEELSRLANLKIQEAIQLTKDRSCGNLNEWRIDTLYTYGYFPVHPSFEQDYKKLVQEANELFTRAGKLYKGPVLNTARTSMAVLPPHFGLRCTEGKIKVVTANDFDLTEVNDRLQKLFPEIRDFFKEETCSSATGWYVTTIRKDCEFVSIAYTQTDRFREFSKRMEEYAHLYYRKTVLDKSMNCPSVNDKPAKGVACENGKPAVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLK2</accession>
    <name>D7VLK2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proton-translocating NADH-quinone oxidoreductase, chain M</fullName>
            <ecNumber evidence="7">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nuoM</name>
        <name evidence="7" type="ORF">HMPREF0766_11872</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Membrane</location>
            <topology evidence="1 4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.5" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000187.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11872"/>
    <dbReference type="EnsemblBacteria" id="EFK58475">
        <property type="protein sequence ID" value="EFK58475"/>
        <property type="gene ID" value="HMPREF0766_11872"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_4_3_10"/>
    <dbReference type="OrthoDB" id="535707at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="6">
        <location>
            <begin position="124"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="481" mass="53074" checksum="AB558360B4C1EC7E" modified="2010-10-05" version="1">MTNLFILLLLPLISAGVLAFVKNSQPAKIIALTLSLLQLAFTIPFLCQFVPDASVQFEQNYSWIESLGIHFHIGLDGISLPLVLLTNALMPLIVLSTFSKTYKGNLYALVAFMQAGLVLVFTALDAFTFYVGWEIALIPIYFICALWGEGDRIRVNLKFFVYTFLGSIFMLVAIIYLQQQTVNKDFEWSSFAALDLTGSVQRWIFWAFFLAFAIKIPLFPFHTWQPNTYTNAPTAGTMLLAGIMLKMGIYGLIRWLIPIAPEGVAEYGHIAMILAVIGIVYASIIAIQQKDIKRLIAYSSIAHVGLISAGVFAWNLQGLQGAMIQMINHGISVIGLFYVLDIIASKTGTRSLADLGGLAKRMPNLAIFFLIIVMGAVGLPLTNGFVGEFLLLMGVYKYGFWYAVFAGLTLILGAVYMLRLYQKSMLGPLKEQNSHVTDINGHEIVLLSIVVIAIIYIGVTPNGLLGLSEASVQQLLQQVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLM8</accession>
    <name>D7VLM8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11898"/>
    <dbReference type="EnsemblBacteria" id="EFK58501">
        <property type="protein sequence ID" value="EFK58501"/>
        <property type="gene ID" value="HMPREF0766_11898"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2511009_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="85" mass="10341" checksum="E6329B67561EF66B" modified="2010-10-05" version="1">MIRHIRRLYFTNQFFYSLLGMALLFTVSFFVKGMFLVSGIVFWLLLICWVWDLMFLHFGKNRVEIERHYPENYPTEMTIILSLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLN3</accession>
    <name>D7VLN3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000262.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11903"/>
    <dbReference type="EnsemblBacteria" id="EFK58506">
        <property type="protein sequence ID" value="EFK58506"/>
        <property type="gene ID" value="HMPREF0766_11903"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069787_0_0_10"/>
    <dbReference type="OrthoDB" id="1745181at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="320" mass="36489" checksum="24CE39E6C2165893" modified="2010-10-05" version="1">MREPSFIDRNKEKWATIESNLANKADIDPDELASNYIELTNDLAYAQTFYPQSKTKQYLNELSLIAHQKIYKDQRASNNQFLHFVNYEIPEAIWKIRKQLFYSLLIFCLAVGIGFLSAHYDEQFVRLILGDGYVDFTTEKIKEGDPAAIYDEGGMFGSALAITINNVRVAFYAFIFGIFYSIGSGYILFSNGIMLGAFHYMFFKYGVMQEAMSAIWIHGTIEISVIIIAGGCGLTLGNSMLFPKSYTRMESFKRGAKLASKVLISTVPFFIIAGTLEGFVTRFYQSSLAMCLAIIFASLFAIVYFYIWRPYQLARKFEWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM13</accession>
    <name>D7VM13_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001196.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12010"/>
    <dbReference type="EnsemblBacteria" id="EFK58018">
        <property type="protein sequence ID" value="EFK58018"/>
        <property type="gene ID" value="HMPREF0766_12010"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077423_0_0_10"/>
    <dbReference type="OrthoDB" id="1108674at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016907">
        <property type="entry name" value="UCP029033"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029033">
        <property type="entry name" value="UCP029033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="244" mass="26741" checksum="D4CA10EDA137EACD" modified="2010-10-05" version="1">MKSNAVVIAVIAGLSFIIFGAVLGGAYRYKFKSSNTINVTGNAKKDFESDLVKWTAVYSRKSMELSEASEQLKRDRDLVRDFLIKQGIKSNEIRFNAVSITKDFNYTNDGNGNSYSTFSGYSLSQNVSIESRDLDKVDAASREISTLISQGLELSSNTPSYYYSKLEDLKLELISQASSNAHLRAGNIAKEAGSSLGDLVKADLGIFQITGQNDNEEYSYGGAFNTTSRSKTANITVKTSYLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM15</accession>
    <name>D7VM15_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ser/Thr phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001202.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12012"/>
    <dbReference type="EnsemblBacteria" id="EFK58020">
        <property type="protein sequence ID" value="EFK58020"/>
        <property type="gene ID" value="HMPREF0766_12012"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074761_0_1_10"/>
    <dbReference type="OrthoDB" id="1355703at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011152">
        <property type="entry name" value="Pesterase_MJ0912"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000883">
        <property type="entry name" value="Pesterase_MJ0912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="248" mass="27945" checksum="7027CCD783A8AECA" modified="2010-10-05" version="1">MIRLAIISDIHGNLPALQCVLEDIRLRVINQIYCLGDLIDFAPWGNEVIDQIKTLGIPCLLGNHDERIAFDQDIRPLPHHSEEETAVRYLAINHSKATITSAHKEFLAQLPYQLKMVYKVGSKQWNIQLVHASTRSNDEYVYEDHEETDLIDMLSQSDADLLAMGHTHLSYQRKVTLPSGKISTALNCGSVGRSKENDRKATYAVITLTEEALEAEIIKVDYPIAEVAKAIAESSIPDFYTEFLLKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMB6</accession>
    <name>D7VMB6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001427.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12113"/>
    <dbReference type="EnsemblBacteria" id="EFK58121">
        <property type="protein sequence ID" value="EFK58121"/>
        <property type="gene ID" value="HMPREF0766_12113"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_11_1_10"/>
    <dbReference type="OrthoDB" id="1558163at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="261" mass="29766" checksum="BF83E0B9FE82400D" modified="2010-10-05" version="1">MRYLILGCGWVGEYVARLWIAEGHEVWASTTSSEKYHRLLSDGIFAFVHNFDDENAVPDNFPESFDYILISVPATKRHSEDILIKRFDRVFGFVSGLTYNKLIFLSSVGIYPDVSGDMFENGWERNQLDAKLLSAEESIQRLSRVIVYRLGGLFGQERIFAKYFQHKVCTTGGQLCNFVHLEDVAALIRLGFAFDLTNGLYNVVTPAHPLKHDVILASARKYGFAVPEAFRDEDSFQKKVHGSLLQDELNYTFKFPSPLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMD2</accession>
    <name>D7VMD2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001459.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12129"/>
    <dbReference type="EnsemblBacteria" id="EFK58137">
        <property type="protein sequence ID" value="EFK58137"/>
        <property type="gene ID" value="HMPREF0766_12129"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_12_9_10"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="202" mass="23656" checksum="E555F05CE611E866" modified="2010-10-05" version="1">MNVRFRDINEKKAAIFNTTIALIGEHGFHGTSMSMIAKSAQVATGTIYHYFPSKDCLIEELHLECKKFLNAHIFENISEIKDYKEKFFTIWKRFIHYGLMQPDMFGFLEQFYSSPYMENIKEKYRHSAISENNIHDFLVEGVKSKQLKDLDINILLTSYIGVATSTIRIILYAKVNYTETHYDQLIQIVWDGVSNENKYEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMF6</accession>
    <name>D7VMF6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001497.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12153"/>
    <dbReference type="EnsemblBacteria" id="EFK58161">
        <property type="protein sequence ID" value="EFK58161"/>
        <property type="gene ID" value="HMPREF0766_12153"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033WI2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1437376_0_0_10"/>
    <dbReference type="OrthoDB" id="2042011at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="199" mass="22461" checksum="F82D8E230ABE8CD4" modified="2010-10-05" version="1">MFKFLIILGLIGLVIYFVSRKLSGLTGSSSGAIRKGQFQLMHTPTALITKVSKKTFVNVGIGVILLLIVVLLAVKIKILLFLLPISFYMIGQLFVLTNHVKATRNQQIWFDPQQEEVIVESLNKQTIRFKLQTDVKAVQQIEAVQHTNGVVFGYYRMKTTAGIVEIPYLVMKNDAVYPFANAVHKHFSPSLQKRLFPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMJ0</accession>
    <name>D7VMJ0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">rpsT</name>
        <name evidence="8" type="ORF">HMPREF0766_12210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992614.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12210"/>
    <dbReference type="EnsemblBacteria" id="EFK57137">
        <property type="protein sequence ID" value="EFK57137"/>
        <property type="gene ID" value="HMPREF0766_12210"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160655_3_2_10"/>
    <dbReference type="OrthoDB" id="2005443at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK57137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="84" mass="9576" checksum="D645F6382604BD48" modified="2010-10-05" version="1">MANHKSAIKRIRANATKRLRNRYQAKTTRNAIKKLRNTTSAEEAKTLLPRVISMLDRLAKKNVIHKKKAANNKSKLTKLVNKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VML2</accession>
    <name>D7VML2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992664.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12232"/>
    <dbReference type="EnsemblBacteria" id="EFK57159">
        <property type="protein sequence ID" value="EFK57159"/>
        <property type="gene ID" value="HMPREF0766_12232"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5034BZZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2604250_0_0_10"/>
    <dbReference type="OrthoDB" id="2089736at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="80" mass="9090" checksum="A221E73AA91AB750" modified="2010-10-05" version="1">MGLKLTPLNITLACILVWFFSELGHPETAMISIPWLGVLVVVLAVVDLLFRVWIKDLKRVWMFEIGFILVVGIVTVLIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMQ8</accession>
    <name>D7VMQ8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Abhydrolase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992743.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12278"/>
    <dbReference type="EnsemblBacteria" id="EFK57205">
        <property type="protein sequence ID" value="EFK57205"/>
        <property type="gene ID" value="HMPREF0766_12278"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_4_0_10"/>
    <dbReference type="OrthoDB" id="1470522at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107354" description="Abhydrolase_3 domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="95"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="309" mass="35357" checksum="914713677F6A283B" modified="2010-10-05" version="1">MLFDMKYIRSFFILLFILLTAAVSAQSDFPRDTSFTLNSAYQKDRKKFPDIRTVTEYKGDDIRTQKNILYKEIGDRKLLLDIYAPAKQDRKYPCVIMIHGGGWRSGDKDMMAGFASNLSLRGYVVLSVGYRLSLEAKYPAAVHDLEDAIVWARKHADQYQIDKRKIVTLGTSSGGQLASLLGTNTYSDRRKQVQATVNIDGILAFHHPESAEGEVAALWLGGKYEEVPKIWEQASALYQVSKRTAPVLFLNSSFPRFHAGREDMILKLKKYGTDTEVCTFDPSPHTFWFYEPWFTPMLEKIDHFLNRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMR3</accession>
    <name>D7VMR3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribose-5-phosphate isomerase B</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpiB</name>
        <name evidence="4" type="ORF">HMPREF0766_12283</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992753.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12283"/>
    <dbReference type="EnsemblBacteria" id="EFK57210">
        <property type="protein sequence ID" value="EFK57210"/>
        <property type="gene ID" value="HMPREF0766_12283"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0698">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091396_4_1_10"/>
    <dbReference type="OrthoDB" id="1346802at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004785">
        <property type="entry name" value="RpiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01120">
        <property type="entry name" value="rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="70"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="146" mass="15867" checksum="4317BA5C03C8858A" modified="2010-10-05" version="1">MSSVKTIAIGGDHAGFDYKKELIPFLQELGYEVKDFGAHSTDSVDYPDFAHPVASAVESKEFDKGILICGSANGVAITANKHQDIRAAICWLEEIAALARQHNDANIVCIPARFISLDLAKAIVKTFMSTDFEGGRHANRVNKISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMT6</accession>
    <name>D7VMT6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="7">RNAP subunit beta'</shortName>
            <ecNumber evidence="7">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">rpoC</name>
        <name evidence="10" type="ORF">HMPREF0766_12306</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992792.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12306"/>
    <dbReference type="EnsemblBacteria" id="EFK57233">
        <property type="protein sequence ID" value="EFK57233"/>
        <property type="gene ID" value="HMPREF0766_12306"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_3_1_10"/>
    <dbReference type="OrthoDB" id="4421at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01322">
        <property type="entry name" value="RNApol_bact_RpoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012754">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02386">
        <property type="entry name" value="rpoC_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RPOLA_N" evidence="9">
        <location>
            <begin position="249"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="822"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="896"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="903"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="906"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK57233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1426" mass="159311" checksum="AA8232A67CB97247" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMW2</accession>
    <name>D7VMW2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12332"/>
    <dbReference type="EnsemblBacteria" id="EFK57259">
        <property type="protein sequence ID" value="EFK57259"/>
        <property type="gene ID" value="HMPREF0766_12332"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_10_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="492" mass="55423" checksum="A1D7077DF2A7596A" modified="2010-10-05" version="1">MNNDKINIISPAISPQLIPIQLRRVIGVKTEPKKSANLDYKYFTMKKASYILIMILLLMGSRPLLAQKRELSLQEALIMARQGNKTLQVQILEEKNAVEQTRESKGKLLPDLAAGVAYSYYFDRQNIFLPGSFAGTNKAVQEVAVGGRNAFNGFISLYQPVMDLGAHRLTKVSRINEKIQTGKTEDLKSRVALGVSTRYLSILMMKRQLNLLLQSHERNVRALKDSRALLAQGRGLKSDTLRSFIAVENLRSSVSYLNNNIEVSGMELKRLIGLEDAQELELTDELESDVKVDQADFLNVSEALEIAESNRKDLNVQELVIAMREQKIYATRAELLPKIAVIGQYQVQAQADNLKFNNYVWPRTSFLGLQVSVPIFNGGQSKSRISQARIIAQQEQVRMNDLKDEIRTTLAGIISKWKEAASQLKIQETTVQSAELNHQMTEDRFKNGLGSRLELTDAELALTQAKINYLQAVYNLRILHTELQHALGLLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMX6</accession>
    <name>D7VMX6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992857.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57273">
        <property type="protein sequence ID" value="EFK57273"/>
        <property type="gene ID" value="HMPREF0766_12346"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055269_0_1_10"/>
    <dbReference type="OrthoDB" id="1271038at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="248" mass="28126" checksum="34A8F5B9E3725487" modified="2010-10-05" version="1">MNTHEHTDPPKVKVIFEPQIIEANKPAYFVISVTEDGKNVPLEVVHTMKMHLLVVNEELTWFDHIHPEKQADGTYYVSETFPSAGKYLFFIDYKPVGLPANVSMKLVGVQGRRLRQIPEQDIKLVSVVDGYTVTLLNGNDLKTNTGQSLQFSIEKDGKNLNEKDMESYLGANAHIVMISQADKDFLHIHPMADHRFPIYAHTYIKKSGLYRMWVQFKIDGKVHTADFTVLTSEGEMQGGDHNSHGAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNC4</accession>
    <name>D7VNC4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase-like hydrolase</fullName>
            <ecNumber evidence="1">3.1.3.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.18" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12494"/>
    <dbReference type="EnsemblBacteria" id="EFK57421">
        <property type="protein sequence ID" value="EFK57421"/>
        <property type="gene ID" value="HMPREF0766_12494"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_3_10"/>
    <dbReference type="OrthoDB" id="1204073at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="244" mass="28091" checksum="9BF24CE104F32E93" modified="2010-10-05" version="1">MDLRIKIKTREMIIDTTPYRHFSFDLWLTLIRSNPQYKKKRDQLLQAYFSIDTDPGKVSQVIRYYDLLCNRLSEKLGMHITVQQIYYQILCRLGVNIDAIDTQQLDNFYQETEQLFMQYKPLLIDPQISQLLHRIQSEGKTASILSNTAFIKGSTLRSLLEHYELGQYFSFQLYSDELGHAKPHPAAFEQVLIQAEAVHQSHISPGQIVHIGDNKTADYDGAISAGMQALLIQHKSDEKALQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNE6</accession>
    <name>D7VNE6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin_lipoyl_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993083.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12516"/>
    <dbReference type="EnsemblBacteria" id="EFK57443">
        <property type="protein sequence ID" value="EFK57443"/>
        <property type="gene ID" value="HMPREF0766_12516"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_6_1_10"/>
    <dbReference type="OrthoDB" id="1680841at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="2">
        <location>
            <begin position="40"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="329" mass="36422" checksum="B79FA12088DC9694" modified="2010-10-05" version="1">MKRYIGFLPSLVLVLAFGACKNENKNSDHIIEGKIERDQLSVVTKVPGKIEKILVSEGQHVRKGDTLIMLEIPEVTAKEEQAKGALDAAEAQYEMARKGATDGQLKQLNAKVAGLKEQLDFAEKSLNRLSNLLRDSLVPQQKYDEVYAKYQGAKNQYIAAQAELSDVRNGARVEQQRMALGQKERALGAVNEVNVAAKERFLIAPQDMTVESINLKVGELALAGYAIVNGYLDETTYFRFTLTEKKMAALRQGAEVNVRIPYKDNQVVKGSVSYIKALNSYANIATAYPDFDQQESLFEIKVVPTDKNAARELLTKSNATLDISSMATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNG9</accession>
    <name>D7VNG9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-70 region 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993114.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12539"/>
    <dbReference type="EnsemblBacteria" id="EFK57466">
        <property type="protein sequence ID" value="EFK57466"/>
        <property type="gene ID" value="HMPREF0766_12539"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="23"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="121"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="181" mass="21185" checksum="9C352174BF0C3C2A" modified="2010-10-05" version="1">MEDTLIISKFADEATREEAFGLLLKKYQQKIYWHVRRMVIDHDDADDVVQDIFIKVWRNLGNFREDSQLYTWLYRIATNECITFLNKKKQKQNVSLDDGTSAYLAESLSDGSYFNGDKAQLKLQQALLTLPEKQKLVFNMKYFDDMKYEEISDVLGTSVGALKASYHLAVKKIEHFFHTHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNJ9</accession>
    <name>D7VNJ9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993151.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12569"/>
    <dbReference type="EnsemblBacteria" id="EFK57496">
        <property type="protein sequence ID" value="EFK57496"/>
        <property type="gene ID" value="HMPREF0766_12569"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8TP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060081_0_0_10"/>
    <dbReference type="OrthoDB" id="355342at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="384" mass="45004" checksum="D34F51298BF771BE" modified="2010-10-05" version="1">MNYATQYHIGHHQNPTATETEDFAQTVGRVRRLDAKTKERRRNKKRQNEIGTDNGTTNGFLKCSFLPKLQEAQTVQACGKSEKTERDFYQSLSKLAGHYCIQPMQSRQYGYPYNIALALDSTEEQLRKKFRDWEELRLIQDSKKTYFVSEERYSTGATLYYIPVVPLYRLSKHPNRKQAVQLLQSVCAYLYHIADVPYYRQENSYLYWMYEMVTEWIVSDDENEDTTTYLSEIRQSEQIGERMEQKIYNKHNLSRFAVRLNSFKIKDSFDQDCYKLASEAFALYEQYPNATINRNALPSGEASEEDMENSIGVEKYVSFCADAKGILFQTLFESVNTELQEYGQMEEPTIVKRFDGSDITANTLEFENRVFALIEELIYILNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNU0</accession>
    <name>D7VNU0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993285.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12660"/>
    <dbReference type="EnsemblBacteria" id="EFK57587">
        <property type="protein sequence ID" value="EFK57587"/>
        <property type="gene ID" value="HMPREF0766_12660"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032S10">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130981_0_0_10"/>
    <dbReference type="OrthoDB" id="1698118at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="175" mass="19559" checksum="7A01CA8F06CFA663" modified="2010-10-05" version="1">METAATYQNQIKRKRITLNVVIILLLLLWIPVGIDKITDFTAFKGGILRQPFSDSIGYILIYSLPALELITVLALVMEKYRKAGLILSTVLMTAFTAYIAVALMGAWEKLPCGCGSVISGMNWTQHFFFNLFFLSLSILGLYLWHKLRGSNAGGEATEGASAKRHIKKYFLTSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNV4</accession>
    <name>D7VNV4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_12674</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12674"/>
    <dbReference type="EnsemblBacteria" id="EFK57601">
        <property type="protein sequence ID" value="EFK57601"/>
        <property type="gene ID" value="HMPREF0766_12674"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_1_0_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107089" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="4">
        <location>
            <begin position="124"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="3">
        <location>
            <begin position="436"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1045" mass="116573" checksum="F1102C1DE6A109C0" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP49</accession>
    <name>D7VP49_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Outer membrane protein, OMP85 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12769</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993470.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12769"/>
    <dbReference type="EnsemblBacteria" id="EFK57696">
        <property type="protein sequence ID" value="EFK57696"/>
        <property type="gene ID" value="HMPREF0766_12769"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010929_0_0_10"/>
    <dbReference type="OrthoDB" id="470487at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010827">
        <property type="entry name" value="BamA/TamA_POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07244">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POTRA" evidence="3">
        <location>
            <begin position="72"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Omp85" evidence="2">
        <location>
            <begin position="367"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="782" mass="90088" checksum="5BBA82431AB718D3" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPE5</accession>
    <name>D7VPE5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase</fullName>
            <ecNumber evidence="2">1.7.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.-.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993638.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12865"/>
    <dbReference type="EnsemblBacteria" id="EFK57792">
        <property type="protein sequence ID" value="EFK57792"/>
        <property type="gene ID" value="HMPREF0766_12865"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055322_4_1_10"/>
    <dbReference type="OrthoDB" id="1818437at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="187" mass="20849" checksum="D165D15D7361170F" modified="2010-10-05" version="1">MKILAFAGSNSSASINKKLVSSVSRYYKEAEDIIEIVDLNDFPLPLFSKQVEEEIGIPQEVHNFVSKIDWADLILISLAENNGNYNVGYKNLIDWISRIPKRKIYAEKSIFLMATSPGARGGQSVLGIATARMPFDGGDVLDTFSLPSFNDNFEEGKGVVNMLLRSQLEAKVRKTKRTMAEKLQNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPI5</accession>
    <name>D7VPI5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative AMP nucleosidase</fullName>
            <ecNumber evidence="2">3.2.2.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.4" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993736.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12905"/>
    <dbReference type="EnsemblBacteria" id="EFK57832">
        <property type="protein sequence ID" value="EFK57832"/>
        <property type="gene ID" value="HMPREF0766_12905"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064264_0_0_10"/>
    <dbReference type="OrthoDB" id="1028277at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008714">
        <property type="term" value="F:AMP nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010944">
        <property type="entry name" value="AMN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011271">
        <property type="entry name" value="AMP_nucleosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF6">
        <property type="entry name" value="PTHR43691:SF6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01721">
        <property type="entry name" value="AMN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="77"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="271" mass="29948" checksum="C0D014FC670D5A7F" modified="2010-10-05" version="1">MSKNKEENSPVKAGLKSKEDIVHNWLPRYTGRPLDEFGEYILLTNFSKYLHIFSEMHDNAPIYGTDKPMQSVTAAGITIINFGMGSPMAATIMDLLSAIAPKAVLFLGKAGGLKKKNKIGDLVLPIAAIRGEGTSNDYFPPEVPALPAFALQKAISTTIRDHSRDYWTGTVYTTNRRVWEHEKSFKKYLKSIRAMCVDMETATIFSVGFANKIPTGALLLVSDQPMIPEGVKTEESDVSVTANYVQTHLLIGIDSLKQLINNGLTVKHLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPV4</accession>
    <name>D7VPV4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD dependent oxidoreductase</fullName>
            <ecNumber evidence="1">1.3.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pys</name>
        <name evidence="1" type="ORF">HMPREF0766_13024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.-.-" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993916.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13024"/>
    <dbReference type="EnsemblBacteria" id="EFK57951">
        <property type="protein sequence ID" value="EFK57951"/>
        <property type="gene ID" value="HMPREF0766_13024"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019327_1_1_10"/>
    <dbReference type="OrthoDB" id="453021at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="480" mass="52149" checksum="F4B46E467E1E60C9" modified="2010-10-05" version="1">MKKTQYDAVIVGAGPNGLAAAITLQQQGLSVLLIEGKDTIGGGMRTLELTLSGYAHDVCSAIHPMALGSPFFATLPLSDYGLEFIHAPLAAAHPFDDGSAVFLSRSLSDTAEALGNDAERYRSLIGPFADHWEALASDSMGPLRFPKNPLLMAKFGRYALQPADVLVSRFQNPRTRALWAGMAAHAIQPLHNLASSAVGLMLLAVGHRKGWPIPKGGSQAIADALATYFVSLGGEIRTGVWIEDLDDLPPHKVALFDVTPRQLDKIAGNRLKKSYSKQLKKYRYGMGVFKMDWALDGPVPFRSADARSAGTVHLGNTFEEIAEGEWKTSKGQHVETPFVLLAQQSLFDTGRVPEGKQAVWAYCHVPNGSTQDMSRQIENQIERFAPGFKDRILARNTMDTQAMETYNPNYIGGDINGGIIDIRQLYTRPVLSLSPYRTSLKQVYICSSSTPPGGGVHGMCGYHAARLALQDIFGIRIPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ45</accession>
    <name>D7VQ45_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">grpE</name>
        <name evidence="7" type="ORF">HMPREF0766_13099</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994037.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13099"/>
    <dbReference type="EnsemblBacteria" id="EFK55896">
        <property type="protein sequence ID" value="EFK55896"/>
        <property type="gene ID" value="HMPREF0766_13099"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057217_5_2_10"/>
    <dbReference type="OrthoDB" id="1906715at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK55896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="181" mass="20421" checksum="C946E1D37670DBDF" modified="2010-10-05" version="1">MSEKEHINGEQEAPQEENQPIENTSGEQAENTANEVTLEQQLANAQDKYTRLFAEFDNYKKRTSRERVELIQSAGKDVIAKLLSVLDDFDRALKSMETAQDVQSVKEGIDLVNNKFRKTLEQEGLKEMDVLGQPFDADLQEAITSIPAPSADLKDKVVDVIEKGYYLNDKVIRYAKVVVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQG2</accession>
    <name>D7VQG2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994269.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13216"/>
    <dbReference type="EnsemblBacteria" id="EFK56013">
        <property type="protein sequence ID" value="EFK56013"/>
        <property type="gene ID" value="HMPREF0766_13216"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032PZ9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120514_0_0_10"/>
    <dbReference type="OrthoDB" id="1925142at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046002">
        <property type="entry name" value="DUF5958"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19383">
        <property type="entry name" value="DUF5958"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="142" mass="16802" checksum="6179AEE501B6164D" modified="2010-10-05" version="1">MMLQDEILVNKFGQGLASYEVLLDKFQLFDLMDKNKFLNDLLFLVLQSKPIDEDIGDAIRESGLKPTFTPCVLLLKGVSYHNLKKIAELPAREKEKVLKLFLSLFRVSYQRRFKLERNDPNKWWYWDLSKDENVKKVINQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQH1</accession>
    <name>D7VQH1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994285.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13225"/>
    <dbReference type="EnsemblBacteria" id="EFK56022">
        <property type="protein sequence ID" value="EFK56022"/>
        <property type="gene ID" value="HMPREF0766_13225"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_14_0_10"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="23"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="187" mass="21557" checksum="31E0E867657D3D37" modified="2010-10-05" version="1">MVRTNLDLLSYISNLYNGQDRKDDIILRKFEKGQLLLQQGDPLSRLFIVNDGITKCYFREENGKEFVVEFLGKGEILGEVEVISRINCLCSIEVLAETEAFSIAVPYFRMLLEKDIVFNRLLMESFSSRIVNTSSRASFQQLYTVEYNLSKLFQLQADQQLDISKEDMAAYLGITIRSLNRTLKSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQI4</accession>
    <name>D7VQI4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994311.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13238"/>
    <dbReference type="EnsemblBacteria" id="EFK56035">
        <property type="protein sequence ID" value="EFK56035"/>
        <property type="gene ID" value="HMPREF0766_13238"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0323">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_682761_0_0_10"/>
    <dbReference type="OrthoDB" id="1049077at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="422" mass="48691" checksum="C3E829E6E9472AEF" modified="2010-10-05" version="1">MKNKANVTNASIDSAGLPKDYRQAIAEYIWNGFDAKATHVNLYAEANELGHIQRIVIEDNGEGIPLETLNISFGNFLDSLKKKNIQRSSYTRGKKGKGRFSFSLFATRATWQTVYLHEGSLLEYSIVIERNQKDEYEDINKVISKAAHTGTKVILEGIFGITAAQLNSAEFNTFLAQEFGWFLLLNKDLGFNLSISDEPLGYKQLILEQDAVVWTIADHQEQVYPFRINYIRWGDSIGDRYYYYFLNKDKVEIAKELTSYNNNAIDFHHSVYIESPFFDSFERESLADGEQDNLFSQLNHHIVYRKLNNDLKEFLYRKQKKYIKEKAAATYLADIEQKALLPVFSSAEQDQKQDLLHVIKELYCIQPKIFMGIKAETEKTLIGLLHLLLSTPQRQNILPLMEQLTPLTEEERNLLSKVLKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQK8</accession>
    <name>D7VQK8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_13262</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994364.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13262"/>
    <dbReference type="EnsemblBacteria" id="EFK56059">
        <property type="protein sequence ID" value="EFK56059"/>
        <property type="gene ID" value="HMPREF0766_13262"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_1_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107155" evidence="2">
        <location>
            <begin position="37"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="4">
        <location>
            <begin position="152"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="3">
        <location>
            <begin position="454"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1061" mass="117735" checksum="09C775C027BD3EB2" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQX3</accession>
    <name>D7VQX3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase, alpha/beta domain protein</fullName>
            <ecNumber evidence="3">3.1.1.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.24" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13377"/>
    <dbReference type="EnsemblBacteria" id="EFK56174">
        <property type="protein sequence ID" value="EFK56174"/>
        <property type="gene ID" value="HMPREF0766_13377"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_2_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047570">
        <property type="term" value="F:3-oxoadipate enol-lactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107455" evidence="1">
        <location>
            <begin position="21"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="68"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="337" mass="38930" checksum="093B242F109A8A64" modified="2010-10-05" version="1">MMRYGHILIYILLFCGTAQAQNKRPVLDIMLTNYAYPYEVHYLNFQSQGQEIRMAYMDVQPSQSNGKTVMLLHGKNFNGAYWKTTVESLVKEGYRVIVPDQIGFGKSSKPVGYQFTFQQLACNTKLLLEELKVNRIYLLGHSMGGMLATRFALMYPDMVGKLILENPIGLEDWKLVAPYTTIDENYQNELKADYETTRNYQSGFYYDNKWKTEYDEWVYLLTGWTKSPDYPIVAMNNAQTSDMIFTQPVVYEFSNIKTPTLLIIGTRDRTAIGKNKVKDSAVREKMGLYQFLGKETQQKIKRSQLVELDNVGHLPHIEVFDRFIKPLKAFLANQTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQY2</accession>
    <name>D7VQY2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994526.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13386"/>
    <dbReference type="EnsemblBacteria" id="EFK56183">
        <property type="protein sequence ID" value="EFK56183"/>
        <property type="gene ID" value="HMPREF0766_13386"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031NDJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1988660_0_0_10"/>
    <dbReference type="OrthoDB" id="1878792at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025695">
        <property type="entry name" value="DoxX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13781">
        <property type="entry name" value="DoxX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="132" mass="15271" checksum="1BEA956F0AE554A1" modified="2010-10-05" version="1">MARTNSLNPVSFEKLIISMVWLINGLFCKVLDFEPRHQQIVATILDQEHARTLTVLIGLAEIVMAVWILTGFRSRLNAITQIAVIITMNIIEFQVVPDLLLWGRFNIVFALLFSAFIYYTEFVRYKKARPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR89</accession>
    <name>D7VR89_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase CocE/NonD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994667.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13493"/>
    <dbReference type="EnsemblBacteria" id="EFK56290">
        <property type="protein sequence ID" value="EFK56290"/>
        <property type="gene ID" value="HMPREF0766_13493"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2936">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015590_5_0_10"/>
    <dbReference type="OrthoDB" id="327988at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepX_C" evidence="1">
        <location>
            <begin position="361"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="621" mass="71611" checksum="A4EACFF37E95AB21" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRE3</accession>
    <name>D7VRE3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994734.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13547"/>
    <dbReference type="EnsemblBacteria" id="EFK56344">
        <property type="protein sequence ID" value="EFK56344"/>
        <property type="gene ID" value="HMPREF0766_13547"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZP86">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1260785_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="219" mass="25528" checksum="05552BE8971F5121" modified="2010-10-05" version="1">MKIRSPLWVSIVLVLLIISCNTYPDKNPGRNPAQSNQMATLSDIRFGKTIDKTLEIWGMSLKDNNNKASSSKIDFEEFTLKKDVPAELYSIDLSHKFRNISIFYDKKTKVIFRYELRISGKDLVEEMIKVFKEKYGSPLFYRDQDDKSGSVFIDQEGNQIEDSERSYYQWNDKKNRTSFFMIRKNEAQSEVLEIIAMERNSKRNQQESVSGGTETVFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRF9</accession>
    <name>D7VRF9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 15" type="primary">rpe</name>
        <name evidence="15" type="ORF">HMPREF0766_13563</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994754.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13563"/>
    <dbReference type="EnsemblBacteria" id="EFK56360">
        <property type="protein sequence ID" value="EFK56360"/>
        <property type="gene ID" value="HMPREF0766_13563"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0036">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054856_2_1_10"/>
    <dbReference type="OrthoDB" id="1697639at2"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="145"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="178"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="200"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFK56360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="226" mass="24475" checksum="4B1724B56176C484" modified="2010-10-05" version="1">MSLQKHLIAPSVLAADFAKLYDDIQMVNNSEADWFHIDIMDGVFVPNISFGFPVMQAIAKHATKPLDVHLMIVDPDRYLKVCKDSGAAVITVHYEACTHLHRTLAAIKELGCKAGVALNPHTPVSLLKDVIRDIDLVCLMSVNPGFGGQKFIEQTYNKIKELRMLAAGVNDNLLIEIDGGVGHQNIGALLRAGADVLVAGSSVFAAENPTQTIADLKAVDPQLQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRI9</accession>
    <name>D7VRI9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13593"/>
    <dbReference type="EnsemblBacteria" id="EFK56390">
        <property type="protein sequence ID" value="EFK56390"/>
        <property type="gene ID" value="HMPREF0766_13593"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z967">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083883_1_0_10"/>
    <dbReference type="OrthoDB" id="1624082at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021729">
        <property type="entry name" value="DUF3298"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025303">
        <property type="entry name" value="PdaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037126">
        <property type="entry name" value="PdaC/RsiV-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11738">
        <property type="entry name" value="DUF3298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13739">
        <property type="entry name" value="PdaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PdaC" evidence="2">
        <location>
            <begin position="79"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3298" evidence="1">
        <location>
            <begin position="194"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="291" mass="33192" checksum="FC64A04E7292920F" modified="2010-10-05" version="1">MGSGFLIILNKHFHKKMGIGKMRYGITCGIFAALLWTSCHSGNEGQGDSQVARDTLRYKLVDFYENSPYFIEGESGIDTTYFKASYPSFENDKINQLLRSSILIDGEDSVRQAAESFLGGFNEFVEDAANPSYHIAWFRELHSYVVLNNTRILSIATQIDDFSGGAHGNHVMILSNFDILNNKKITLPDLISKEKQKELLKIAEKYFRKAERLKDNENLSGKYFFEDGKYALAENFALEKDSLLFYYNPYEIKSYVEGSTALRIPYQEIEHLLTDSGKVYLQQISSNQPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRP6</accession>
    <name>D7VRP6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994915.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13650"/>
    <dbReference type="EnsemblBacteria" id="EFK56447">
        <property type="protein sequence ID" value="EFK56447"/>
        <property type="gene ID" value="HMPREF0766_13650"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_28_4_10"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="186" mass="21119" checksum="4FBFD7C1118950D7" modified="2010-10-05" version="1">MDMDTRSAILTLADKLIREKGFNAFSFSDIARQLNIRNASIHYHFPTKTALGVAVIDYHIDNFKKTKHNSANLSALEKLETFFGIHAQIQLEKRVCIVGSLAPDYHTLEDCMTDRLKEFSSVMLDWVTGFLEEGKQSGVFNMNTDVRTKALLIISNMIAIVPLARLTDKNDFKLIKEAIKKELLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRR2</accession>
    <name>D7VRR2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RND transporter, HAE1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bpeF</name>
        <name evidence="5" type="ORF">HMPREF0766_13666</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994956.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13666"/>
    <dbReference type="EnsemblBacteria" id="EFK56463">
        <property type="protein sequence ID" value="EFK56463"/>
        <property type="gene ID" value="HMPREF0766_13666"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_10"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="543"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="873"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="898"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="928"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="974"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1005"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1067" mass="116259" checksum="B139B60F90F81ADA" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRU5</accession>
    <name>D7VRU5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995050.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13699"/>
    <dbReference type="EnsemblBacteria" id="EFK56496">
        <property type="protein sequence ID" value="EFK56496"/>
        <property type="gene ID" value="HMPREF0766_13699"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104147_2_0_10"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="179" mass="20658" checksum="DFCEBC02E774C989" modified="2010-10-05" version="1">MKILKKILLAILALVVILLIAALFLKKDYAVKREIIINKPREVVFEYIKYIKNQNYYSKWATMDPNMKKTYTGTDGTPGFISAWDSEQKDVGKGEQEIKKIKEGERIDMEIRFIKPFESKDQAYMITESASPTSTKVIWGFDGHMNYPMNLMLLCMDFDKMLGGDLDTGLQRLKGQLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS95</accession>
    <name>D7VS95_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995427.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56646">
        <property type="protein sequence ID" value="EFK56646"/>
        <property type="gene ID" value="HMPREF0766_13849"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032SSC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_993018_0_0_10"/>
    <dbReference type="OrthoDB" id="1584889at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="269" mass="31060" checksum="FA9F8B6D633C79E6" modified="2010-10-05" version="1">MNLQKSGTSTLSSPTGDTVINFLDTAYRDVIMIEDHHVAHEGNNYLIDIPLKEHQDTLHVFFLSARVPVDLFKNSASFFPDVKEFILIVPDWEFYQRVAEDATKNGIVLEPATTNVYYHIKRVEDQILVDSMRISGNDHPQLDFTNPKVPKDHFVSYRSEQYGSVCCPKDPRWEIIEEDGPFIKDFENRNNVRIKGIYRQNNGKEGEHITYYTLPGLSPEQRLKFIVEKRSQWIVNKTTKTTDFAPQVFTPQVVPFVKTGFNKTTPVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSE3</accession>
    <name>D7VSE3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13897</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995527.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13897"/>
    <dbReference type="EnsemblBacteria" id="EFK56694">
        <property type="protein sequence ID" value="EFK56694"/>
        <property type="gene ID" value="HMPREF0766_13897"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_1_4_10"/>
    <dbReference type="OrthoDB" id="1200399at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107323" evidence="2">
        <location>
            <begin position="28"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="73"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="374" mass="41711" checksum="7676BBD8357564B3" modified="2010-10-05" version="1">MYHSISINRKKAALLALTILLVLLLSACSQKEQEKTQAKKEYAKSMNYKTAHVQVINPEYEISVPAELKPYEQVSVYAKVTGFVQRLYVDRGDRVRKGQLLAVLEAPEMQQQYLSDKSNEQKVYSDYLYAKQAYDRLITASKTTGAIADIELDRAKSVMESAKSTYDASKAGTAHSSQLQQYLRITAPFDGVITQRNISVGALAGAGSNIPLFMIAQSNKLRLTLSLPEKHASSVQQEMNATFTVSSQPGKTFDAGLSRTSGLLDQQDRSLTLEFDVNNPSDELQGGDYAQVKLKLKRKNPTNWVQTRSILNTQSGTYILTLNNDEVKRIAVHEGIRLDTLTEVFGNLDPEDKIIIKPSEEIKEGRIIKQDSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSM6</accession>
    <name>D7VSM6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13980"/>
    <dbReference type="EnsemblBacteria" id="EFK56777">
        <property type="protein sequence ID" value="EFK56777"/>
        <property type="gene ID" value="HMPREF0766_13980"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3157931_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="48" mass="5674" checksum="DAE5F18C7101AD8B" modified="2010-10-05" version="1">MGDIQLPNGKGIIWLFIGFDYYNKSYFKNNKKQKMKNIAIIMIMSDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSX5</accession>
    <name>D7VSX5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pstA</name>
        <name evidence="8" type="ORF">HMPREF0766_14079</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995870.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14079"/>
    <dbReference type="EnsemblBacteria" id="EFK56876">
        <property type="protein sequence ID" value="EFK56876"/>
        <property type="gene ID" value="HMPREF0766_14079"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_2_2_10"/>
    <dbReference type="OrthoDB" id="1763210at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="65"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK56876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="284" mass="30932" checksum="B15D6D5B02EA2A00" modified="2010-10-05" version="1">MGFKLKRLTPIIEWGTLLGSTILVCLFLVIILWEIASKGASVVSWDFITTLPKEAMTKGGILSPIIGTVLLTLITALFAIPFGICCAIYLNEYAQDNMLTRLIRAAIRNLSGVPSIIYGLFGLALFVQALNMGTSLMAAGLTLGLLSLPYIITTTEEALMRIPQSTREGALGVGATQFECIKDVVLPSAMPGILTGVVLTLSRAAGETAPILFTGAAFYINGTNGYMNQEFMALPYHLYMLSTQHQAIEEVRPIAYGTALILVVVVFLMNLTAFYIRYKYRKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSY9</accession>
    <name>D7VSY9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995887.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14093"/>
    <dbReference type="EnsemblBacteria" id="EFK56890">
        <property type="protein sequence ID" value="EFK56890"/>
        <property type="gene ID" value="HMPREF0766_14093"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZAAB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_640533_0_0_10"/>
    <dbReference type="OrthoDB" id="618011at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="415" mass="48509" checksum="D45338E018F3B662" modified="2010-10-05" version="1">MGILDMFTTNKKEIYIEGDVLNYLEYGEMEQVDLSKLKYAYAEVLGGDPFLFLFDHRQWYISGLLKGFDTVYRQLSVRFGFDDTVFYKVTGQTNDMKKRIWLKKYPRNYSILQQGDVADYTDGFEVMTSAPLFVSWDTSYDELATLNVGHLEKSDYDIRIFVFDYPVRIGNMVVEGLEAYYDNERTDIAVQHYICALYNETHTDTSYYEIKAEWMQHIPIDVDVCGYERDDQKHLTFDIEDVWLSISYTYDTEEGYDDGSTSLSMQNKRSYPDLLDHPDYADDHISIDTYIPFNTVHEIVEDYRKNINVVALPSLIRKTLDNKSGIWLDKNNGKIGFAGEEMCLIYNVHDIKRICFYNLLPAKGPGYASFEVQLKDKEHTDTVFYGDCYAFDRYADQLREVFGLEVYIPEADYNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT14</accession>
    <name>D7VT14_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14118"/>
    <dbReference type="EnsemblBacteria" id="EFK56915">
        <property type="protein sequence ID" value="EFK56915"/>
        <property type="gene ID" value="HMPREF0766_14118"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3317197_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="39" mass="4799" checksum="12920C7C01B840CC" modified="2010-10-05" version="1">MGIMKIWNSKKWLRNLTYWMKKDILAFELQVLTLQSQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT20</accession>
    <name>D7VT20_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1281_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995973.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14124"/>
    <dbReference type="EnsemblBacteria" id="EFK56921">
        <property type="protein sequence ID" value="EFK56921"/>
        <property type="gene ID" value="HMPREF0766_14124"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZBIW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1668276_0_0_10"/>
    <dbReference type="OrthoDB" id="1024852at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041329">
        <property type="entry name" value="YubB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18406">
        <property type="entry name" value="DUF1281_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1281_C" evidence="1">
        <location>
            <begin position="51"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="162" mass="19199" checksum="E7903C4D9106740D" modified="2010-10-05" version="1">MPNWCNNTVVFEGKPEAIEQVTQLFKSMAERERKENCGQLPDFIDDSNGGYFFEVYESDTGIFNYQTKWSPNAEAVKQIAEHYNIDFQLDYEELGCLVYGRTMFSDKLLIDIYLEDEDFDSYELDKETDTYHFEGKEYDSEWEILDTLLERKIENQLNTIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT60</accession>
    <name>D7VT60_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fixA</name>
        <name evidence="5" type="ORF">HMPREF0766_14164</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14164"/>
    <dbReference type="EnsemblBacteria" id="EFK56961">
        <property type="protein sequence ID" value="EFK56961"/>
        <property type="gene ID" value="HMPREF0766_14164"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="248" mass="27584" checksum="85940A8B45282F1B" modified="2010-10-05" version="1">MTNEVVIKTEKLTKRFGDFIATNEVTFEVYEGEIFGFLGANGAGKTTAMKMLCGLSKPSSGNATIAGFDIYKQTEEIKKNIGYMSQKFSLYEDLTVIENIQFFGGIYGLSDKQLNAKSNELIETLGLQSEAKKLVASLPLGWKQKLAFSVAVIHEPKIVFLDEPTGGVDPVTRRQFWDLIYSAADRGITIFVTTHYMDEAEYCNRISMMVDGVIKALDTPANLKQQYSAASMDDVFYKLARGAKRKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT81</accession>
    <name>D7VT81_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_14185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996110.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14185"/>
    <dbReference type="EnsemblBacteria" id="EFK56982">
        <property type="protein sequence ID" value="EFK56982"/>
        <property type="gene ID" value="HMPREF0766_14185"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_2_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107658" evidence="5">
        <location>
            <begin position="22"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="203"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="474"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK56982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1064" mass="117423" checksum="DFD77AE43C3CA68D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT92</accession>
    <name>D7VT92_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucosamine-6-phosphate isomerase/6-phosphogluconolactonase</fullName>
            <ecNumber evidence="2">3.5.99.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nagB</name>
        <name evidence="2" type="ORF">HMPREF0766_14196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996144.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14196"/>
    <dbReference type="EnsemblBacteria" id="EFK56993">
        <property type="protein sequence ID" value="EFK56993"/>
        <property type="gene ID" value="HMPREF0766_14196"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049611_1_0_10"/>
    <dbReference type="OrthoDB" id="1828393at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="PTHR11280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="1">
        <location>
            <begin position="13"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="248" mass="28030" checksum="9D825D646D42AC3D" modified="2010-10-05" version="1">MLLEKLNIDVADTAQEIGERAGKAIEAALVELQTKKDEIRVIFAAAPSQDFMLDYLAKSTKIEWSKIVAFNMDEYLELETGAPQLFSNYLENRLFRHIHPKGKYFINPDQPAAEEIARISALISVAPIDVVCLGIGQNGHIAFNDPPVADFEDSHIIKQVELDEVCRMQQVVDECFATIEDVPKYALTLTIPTIMDADQLFCVVVGEHKREAVKHTLNSPINTEWPSTILRKHKDCHFFFDRKAYPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT96</accession>
    <name>D7VT96_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_14200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996155.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14200"/>
    <dbReference type="EnsemblBacteria" id="EFK56997">
        <property type="protein sequence ID" value="EFK56997"/>
        <property type="gene ID" value="HMPREF0766_14200"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_2_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="131"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="370"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1031" mass="114762" checksum="8464F41773B57CB1" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTA3</accession>
    <name>D7VTA3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57004">
        <property type="protein sequence ID" value="EFK57004"/>
        <property type="gene ID" value="HMPREF0766_14207"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3140830_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="49" mass="5942" checksum="8CEF1F684AB2DD2B" modified="2010-10-05" version="1">MNKFLTLIFYLPHLWKIVTDLYPKTDFSLISNLYRHFFAIENQSRFTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTD7</accession>
    <name>D7VTD7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996268.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57038">
        <property type="protein sequence ID" value="EFK57038"/>
        <property type="gene ID" value="HMPREF0766_14241"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z82T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_911858_0_0_10"/>
    <dbReference type="OrthoDB" id="1513483at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025332">
        <property type="entry name" value="DUF4238"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14022">
        <property type="entry name" value="DUF4238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="305" mass="35971" checksum="6CF496090EC192AD" modified="2010-10-05" version="1">MTEPIGQHIVPRVYLKNFSTSIKKKDYFVDVFYKKQKGINIPRVNIKNICKINEFYTFDHSPSEIDKRWLEKYYANNIESHYNSIYNLLIDEKTEEITPEIKNKILRHIISQELRTPKIAQALNSLTDRTIDYVFNSHEQLGTEKKLYTEDGKLAYDWSEKSIDEAKTKNRNENRQISNIECISRLRGLVKLKFSYHIMVVKYNSPIGLISSDRPVYTSEPLYSPSCRISLPIDKYHMINLYPFIEDTDQNIILRIEHGKVASEQAVRILNISQLERAEHFVYGEKNDILKTIQDLDFLEKKQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTK6</accession>
    <name>D7VTK6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996416.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14310"/>
    <dbReference type="EnsemblBacteria" id="EFK57107">
        <property type="protein sequence ID" value="EFK57107"/>
        <property type="gene ID" value="HMPREF0766_14310"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108923_1_0_10"/>
    <dbReference type="OrthoDB" id="1914312at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="140" mass="15929" checksum="B0BBC7542CF01D76" modified="2010-10-05" version="1">MKTQPQITVEATIDAPVEIVWKAWNTPADIMQWNAADPSWHCPSSKNDLRVNGKFSNRMEARDGSFGFDFEGTYQQVDLHEKISYTMADGREVSTLFSSKGDTTIITTTFDAETENDPEFQKQGWQAILSNFKKYVESAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTL3</accession>
    <name>D7VTL3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996426.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14317"/>
    <dbReference type="EnsemblBacteria" id="EFK57114">
        <property type="protein sequence ID" value="EFK57114"/>
        <property type="gene ID" value="HMPREF0766_14317"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054534_0_0_10"/>
    <dbReference type="OrthoDB" id="946700at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107384" description="DUF218 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="272"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="413" mass="47122" checksum="DFF89A4F381AB137" modified="2010-10-05" version="1">MKTILKLILLTLGTCLSHVSGAQDFSACETPQDWVIAKNYYATFQLAQDSGLSNRILSDPDMHSMLEKRHARYIESANCKDVACFLREFRWNEQEVETIVTVFSKRLQTDKVLKALVKNKLIPSYTYGMDVSGGESAYLAKALRQDLNAMNYVIDVYAGAKKPNYPKIDSISFDSTKKSYLYLLKDVAQDILKDVRRPEEAYYESLWTAVRLLEVNERWDAAQLEPLMQLENKKAYDAIRKTDFGSYPYSLLLTLGAGPEVYDQPISPGGMLRCRMAARSYFQRLAPFIVVSGGRVHPYKTPYIEAIEMKKYLMQVLNVPEEAILIDPHARHTTTNMRNTARILLHYGFPAEKYAIVNSSVPHIDAVEKMADRCVRELGYVPYVLGKRISEVIIEFKPREEALTIDPDEPMDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTN4</accession>
    <name>D7VTN4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001666.1">
        <property type="nucleotide sequence ID" value="NZ_GL379777.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK55793">
        <property type="protein sequence ID" value="EFK55793"/>
        <property type="gene ID" value="HMPREF0766_14354"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZA27">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_879081_0_0_10"/>
    <dbReference type="OrthoDB" id="1553741at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="356" mass="39506" checksum="910F86BC17603873" modified="2010-10-05" version="1">MITRWLRFCLQKIHLVLTDIYINFEFNLSKSEMYNTDSLKNFTIRLVILFIALQSLQAQAQFGKLGDLVNKGVGKALNSSQLKLLKSDPITTNFDDCNQEKTLVADFGKDSVKTDLCTLGAQYTKTTGFRLKPGFYKGTFKSFCLQAGTYGPSRGDAYLFAPLAGPKEKIARTLIANWENHPEIEQSQVQVLLWAIIAKTNFTKLSPELQATAAILLSQKDLSALGSSVIDYLSGEAMQSLTQNLPEPAKTIVEIENKIRGLMYKANASYQEIESLAMLTGVAPVNEKFPRGIWSFHPDGYYIKYLPQGYSVTSVEIYVPQQAGTIDFLPTGDVAVPASRGSQRLGQSNILICDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTR3</accession>
    <name>D7VTR3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001753.1">
        <property type="nucleotide sequence ID" value="NZ_GL379777.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14383"/>
    <dbReference type="EnsemblBacteria" id="EFK55822">
        <property type="protein sequence ID" value="EFK55822"/>
        <property type="gene ID" value="HMPREF0766_14383"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018532_0_0_10"/>
    <dbReference type="OrthoDB" id="390141at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="785" mass="91039" checksum="74C7CDD98DC178D8" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTT5</accession>
    <name>D7VTT5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminotransferase, class V</fullName>
            <ecNumber evidence="5">2.8.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">iscS2</name>
        <name evidence="5" type="ORF">HMPREF0766_14405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002226.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14405"/>
    <dbReference type="EnsemblBacteria" id="EFK55714">
        <property type="protein sequence ID" value="EFK55714"/>
        <property type="gene ID" value="HMPREF0766_14405"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_0_10"/>
    <dbReference type="OrthoDB" id="839689at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="3"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK55714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="380" mass="41859" checksum="C54F5B7FB69BCDD9" modified="2010-10-05" version="1">MQIYFDNAATTPLDPEVIKVMVETMHENFGNPSSIHAHGRQVKTIVEKARKTVANLLHTSPSEIFFTSGGTEADNMAIVRSVIDLGITHAITSPLEHHAVLHTLEELQKEGRIQLNILNVDAKGNVDLEQLEQLLASNPRTFVSLMHANNELGNLTDIQKVAEICHQYNAVYHADTVQTMGHYRHDLSQLKIDFITGAAHKFHGPKGVGFLYINGKNKIKPMIYGGAQERNMRGGTENVYGIVGLAKALELCYNEMEIHQAHIQGIKSYMKEELIKAIPNVSFNGETDPEKSLYTVLNVSFPCTNMADMLLFSLDIEGISCSGGSACSSGSDIGSHVLSAIRASSTRPSVRFSFSKNNTKEEVDIVVNKLKELCNQDVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGH0</accession>
    <name>D7VGH0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002036.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10089"/>
    <dbReference type="EnsemblBacteria" id="EFK60145">
        <property type="protein sequence ID" value="EFK60145"/>
        <property type="gene ID" value="HMPREF0766_10089"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZBIA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041397_0_0_10"/>
    <dbReference type="OrthoDB" id="1159390at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK60145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="391" mass="43714" checksum="72B540049140FFC4" modified="2010-10-05" version="1">MKNIVYNNHINNSSFLGRKPVFTPEEENQILAVFFEQLLLFDYVVISTDKDNFTLTFLIRKLGVPTVEKLFRSGYIKLSIKSTFISSGTGRMLSNGSIDENVIYGQPPLVGGTLVDEDLDPEKNIYLGLQSFNLARNKARELIRVIAPYYLTTDNMDLGTSASGLVIDSYKSNLLDNLGLPYDKEPEHLSLQERKKLLELAHSVLEMGVISKNSFKSYNKYNTFEVAESVYNNIGKAYQIRESASQILRIENTPDLQQIFLNNRFEISDIFKLRHLKTAKFFRNWINKVGENQNSAEVTEAYLAEIKESKTFFNSLQGRVIKNTLLFGASAGLGALIAGPAGALTGAAAQPAIGLGIDYGLSLLEEFATEGLFAGKNPKMFIDKLKDEIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGJ4</accession>
    <name>D7VGJ4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TonB family domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996610.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10113"/>
    <dbReference type="EnsemblBacteria" id="EFK59196">
        <property type="protein sequence ID" value="EFK59196"/>
        <property type="gene ID" value="HMPREF0766_10113"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049705_1_0_10"/>
    <dbReference type="OrthoDB" id="1619668at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="3">
        <location>
            <begin position="370"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="433" mass="47378" checksum="28B6DBDDC441DA03" modified="2010-10-05" version="1">MNRNRPDLEYIRRYHNGELSPREMYELERQAQDDPMLMDIIMGIELSDEETVRKDLSDIKSRITERISDSKIKQMPVWRKWVVAASVLLLLSAGALLMINQQSANKEIASTTLSEPSTPITQDSGDDAEVTDKTSKQASPTPSSTQTDRLANVVTKKNKPTEDIATQAEQADISDEKSTLAAVQPKSPGVRVHISESLAKDSTLVLRGLSDDKLAVISPKEELSTALSGKAAGVRIRGMASNSMVNNVISGQVLDKSTNLPLEGAILKIKNTDLTAVTDSAGQFQLLSSGSNPQVEVRAIGYETQQVSSNQLANNQVKLSPAYATLNEVVVTNYPARKKSVKQLTGPEGGWKAFEKYIKKEIRRTGTSAKGKVELSFIIDPNGKPSHIQVISGIDNVTDQQAVRMLENGPKWKTGEDQQENNITFVSINFSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGK1</accession>
    <name>D7VGK1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996626.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10120"/>
    <dbReference type="EnsemblBacteria" id="EFK59203">
        <property type="protein sequence ID" value="EFK59203"/>
        <property type="gene ID" value="HMPREF0766_10120"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032TJB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078217_0_0_10"/>
    <dbReference type="OrthoDB" id="1021873at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="288" mass="31975" checksum="7199D0F6E7BB8C4B" modified="2010-10-05" version="1">MLKKSIKFTLIIVAASLIFGCQQKQKTTDNTTTDSSAKDSIVTTTNEDVIAFGFLDSLGKHILTLEQDSLPHPEQYDLVLNDQGKGFPVQYKGFQKSTDGDNGRQTADNFDKSAGFLYQLKENKLTSSATAVILTDKAFLSSRKVLIPHAAKDAGTMPAAVQKLVAEKNRKVKNFKNIAQIDEKTLISIVEFEVKNDSALAVLVYSTPGKTITQEYKAKYDDMSTWRVDDGGDFNMDYIDILYAFVYKDNIELVFSDMGAEGYNVTYLKENTGAFVMAKESYGYSAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH01</accession>
    <name>D7VH01_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rpsO</name>
        <name evidence="7" type="ORF">HMPREF0766_10270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="3 6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997051.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10270"/>
    <dbReference type="EnsemblBacteria" id="EFK59353">
        <property type="protein sequence ID" value="EFK59353"/>
        <property type="gene ID" value="HMPREF0766_10270"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148518_0_1_10"/>
    <dbReference type="OrthoDB" id="1990141at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="92" mass="10507" checksum="ECED1A69A7909555" modified="2010-10-05" version="1">MYLSKEYKADIFAEFAGSATNTGSTEGQVALFTKRIAHLTGHLKNNRKDFATQRSLQKLVGKRRSLLAYLYKKDIERYRAIIKGLGLRDIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH21</accession>
    <name>D7VH21_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997100.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK59373">
        <property type="protein sequence ID" value="EFK59373"/>
        <property type="gene ID" value="HMPREF0766_10290"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_899885_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="309" mass="35069" checksum="562EA4D60F397750" modified="2010-10-05" version="1">MKKHFVLYAVYYVLSFVLTLVTVSCKEDSNITEKETLPLNTAKATYPPEEINVSCRNTERKIMYGLDDQGCVSVWQTSYWYVANFKCPGNSYLLNLKNKETIKLYHEKLFCKQNNSYPVVQRGVYDPYESDPVLILNVFGVNSISSLESELSVFNQYSSTNFTVYILLSDGANRMNGTCFFGFESNGKSRTVGFYPANIPIYTYQSVPSVYFDNSEMLYVLKVKFTLPKLILNGVLNTLYNNGIPPQFSIDSYNSAHLTKQIFEQLDIYLPNTISSPYELAAYIRQSGLPSMMISPDIDLSLGTAPVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH74</accession>
    <name>D7VH74_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997210.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10343"/>
    <dbReference type="EnsemblBacteria" id="EFK59426">
        <property type="protein sequence ID" value="EFK59426"/>
        <property type="gene ID" value="HMPREF0766_10343"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073797_0_0_10"/>
    <dbReference type="OrthoDB" id="1968186at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021457">
        <property type="entry name" value="DUF3108"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11306">
        <property type="entry name" value="DUF3108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107466" evidence="1">
        <location>
            <begin position="21"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="263" mass="29830" checksum="9815EDD5D85C04F0" modified="2010-10-05" version="1">MKRIFTLFIIALYCISNAPAQMLPYLKESSYKAGEKLQYKLRYGIVSAATGSLMVSDSKLQFSNPKTFQLTAFGSTSGAFSVLYTVKNKYNSYIDGNTFLPYLYTEDIHEGSYTRQDYVTFDHKKQSAKGKKGTFQSPTPQTFDLLSAYYFSRNLDLSKLKIGDSFRITYFLNDEMASLGIKYLGVEDVKTKLGTLECIKFSPEIKPGRIFKKNSQLYLWVTNDGNRIPVKAEVEILIGSITMELTKAEGLKYKLGQRVSYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHA9</accession>
    <name>D7VHA9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 13">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="8">GluTR</shortName>
            <ecNumber evidence="4 8 13">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 17" type="primary">hemA</name>
        <name evidence="17" type="ORF">HMPREF0766_10378</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 13">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 13">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 13">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4 8 13"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997285.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10378"/>
    <dbReference type="EnsemblBacteria" id="EFK59461">
        <property type="protein sequence ID" value="EFK59461"/>
        <property type="gene ID" value="HMPREF0766_10378"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035113_1_0_10"/>
    <dbReference type="OrthoDB" id="1358620at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="16">
        <location>
            <begin position="7"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="15">
        <location>
            <begin position="183"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="GlutR_dimer" evidence="14">
        <location>
            <begin position="323"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="50"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="192"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="8 12">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFK59461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="413" mass="47563" checksum="E12E69D92C43F3B7" modified="2010-10-05" version="1">MKNLKVIAFTHKHVELKDLGNLVICNEELESRLINLKHSLDIPEIFYIGTCNRVEFVFYGAYELSDDFVAKFMEKLNFCVPQERLQCYLGQVNRYEGLDALNHLLRMSCSLESLVVGEKEILSQVRRAYERCREAGFTGDFLRLMMDRLIKTAKEVYTYTKISRNPISVVSLAYRKLRELKLTTNPRILVIGSGETNQNLAKYLQKHKFENFVIFNRTVENAHTLAQELNAQVYPLSELGNYKNGFDILITCTGAPDAIVNNALYESLLNGETDKKIIVDLAIPNDIDAEVIARHPIHYIEVSSLQAIAEKNIQERYDELTSAECIIKQNIEEFLPIIKQRRVEVAMRQVPEKIKEIKSFAINEVFAQDLSKLDPQAREVLEKVINYMEKKYIKVPMVMAKEILVKTSEAENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHC4</accession>
    <name>D7VHC4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argG</name>
        <name evidence="9" type="ORF">HMPREF0766_10393</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997316.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10393"/>
    <dbReference type="EnsemblBacteria" id="EFK59476">
        <property type="protein sequence ID" value="EFK59476"/>
        <property type="gene ID" value="HMPREF0766_10393"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032784_0_0_10"/>
    <dbReference type="OrthoDB" id="357142at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="394" mass="43390" checksum="AF6C9508011D5943" modified="2010-10-05" version="1">MKKVVLAFSGGLDTSFCCIYLTRDLGLEVHSVIVNTGGFSAEELATIEKRAYELGVKSHAVVDETENYYRDSIKYLIFGNVLKNATYPLSVSAERVCQATAIANYAKKIGAECVAHGSTGAGNDQVRFDMIFNTLIPGVEIITPIRDLKLSREAEIEYLSKHGVEYSAEKAKYSINKGIWGTSVGGAETLTSNQYLPDSAWPTPVTSSTPRQVTIDFEHGEPVALDGNKIGAVRVIQELQAIAQPYGIGRDIHVGDTIIGIKGRVGFEAAAPVILIKAHHTLEKHTLTKWQLAWKDQIAGFYGNYMHEGQMHDPVMRDIEAFLTSSQSTVNGRVYIELNPYRFTILGIDSPNDLMSNKFGTYGEMNNGWTGDDVKGFSKIFGNQTLIWHKVNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHC6</accession>
    <name>D7VHC6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997325.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK59478">
        <property type="protein sequence ID" value="EFK59478"/>
        <property type="gene ID" value="HMPREF0766_10395"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033ZS7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2556545_0_0_10"/>
    <dbReference type="OrthoDB" id="2012105at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="82" mass="9710" checksum="1C40C5777AB331C7" modified="2010-10-05" version="1">MDTPSIIFYLFFAVPYIFCMYWLVKQDKKKYVWGISIVTIIAIIGIIVSQKASKVAIDNYRQHQLDSREIEREEKLDSLHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHS8</accession>
    <name>D7VHS8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_10547</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997691.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10547"/>
    <dbReference type="EnsemblBacteria" id="EFK59630">
        <property type="protein sequence ID" value="EFK59630"/>
        <property type="gene ID" value="HMPREF0766_10547"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_10"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="22"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="346" mass="38606" checksum="094707F422BC846D" modified="2010-10-05" version="1">MQELSSCQFIPSDVQQPGLPLVYGENVSCVFENKEKIIAVDHVSFSVNEGEITSIIGESGSGKSTLLKLIYGLLEPQSGSIRYRGWLVPTRKDKLIPGHPAMKLVSQGFDDLNLYAKVWDNVASQLSNTNLQRKQDKTHEVLEKLKIAHLANQRVADLSGGEKQRVAISRALINEPEVLLMDEPFNQVDAAFRDNLQQDIKQIVKETGLTIIIISHDPAEVLSLSDRLMVMKKGKIVDQGSPEELYYHPTHSYTAQLLAKSNLLSSEQATALGIQTTQQIAIHQEWIKVKRNASGLLKVKDIRFRGFYNEITVGNEHVSLQLVDYPISTIEKGAAVEISIDKYISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI61</accession>
    <name>D7VI61_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997990.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10680"/>
    <dbReference type="EnsemblBacteria" id="EFK59763">
        <property type="protein sequence ID" value="EFK59763"/>
        <property type="gene ID" value="HMPREF0766_10680"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026375_2_0_10"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="252"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="471" mass="54012" checksum="3379B0FAD6433468" modified="2010-10-05" version="1">MYLNTERIYKLIAIASFVVLMILQYQLISSTYTIKSNDLFKKEKNKLKVSYERAIINDKLFPGGQAIIDSVLLPKMSTLDSLYHRDPELFKMRGAEIYHQIVRQLQEGSTMDSLFAELLQKDNLDTHFKYTLVLDGISITFDGHNFIDLLDSRPMSSPDTITIIQGDPRLINPHQMVSSLFISSHLKYSNRVEFSLYADKDGKTLTVLKNILPLLLLSGCCLLAVVGIYFLTFNNWVRQKKMNEMTTDFLNNITHEFNTPLATIQVASKNVRRDIPADSAGMSTINLDIIDRQAGRLDKLINQAINVSKFSPHHVEKDIYNLHELLDESVTDLCINYGKEVEIDYSPKGEEKRYHIVTNRFMFTTLLNNLVENGVKYNNRKDKLIQVWVTVQEQLIELHVKDNGNGIDKETLTHMFKKFFRGKPEYAKNGVGLGLYYVQQTVVQHDWDIKVDTVIGEGSVFTLVIPMVEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI85</accession>
    <name>D7VI85_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 5">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rfbA</name>
        <name evidence="7" type="ORF">HMPREF0766_10704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 5"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998039.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10704"/>
    <dbReference type="EnsemblBacteria" id="EFK59787">
        <property type="protein sequence ID" value="EFK59787"/>
        <property type="gene ID" value="HMPREF0766_10704"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_9_0_10"/>
    <dbReference type="OrthoDB" id="1004719at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="285" mass="31600" checksum="8662BED11C81E154" modified="2010-10-05" version="1">MKGIILAGGSGTRLHPLTLAVSKQLMPVYDKPMIYYPLSTLMLAGIRDILIISTPQDLPHFEKLLGDGFQLGCNFSYKEQPSPDGLAQAFILGAEFIGSDKVALILGDNIFYGSGMSKLLQSCAAIEGGCIFAYPVRDPERYGVVEFDEQKNVISIEEKPKEPKSNYAVPGLYFYDNDVVEIAKNIKPSSRGELEITDVNKEYLRRGNLKVGVFDRGTAWLDTGTIQSLMQAAQFVQVIEERQDLKIGAIEEVAFRMGYINKNQLIKLAEPLSKSGYGEYLINLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIB3</accession>
    <name>D7VIB3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase, S54 family</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_10732</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998096.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10732"/>
    <dbReference type="EnsemblBacteria" id="EFK59815">
        <property type="protein sequence ID" value="EFK59815"/>
        <property type="gene ID" value="HMPREF0766_10732"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055068_9_1_10"/>
    <dbReference type="OrthoDB" id="2053476at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="46"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="208" mass="23714" checksum="CBE8D1F171813646" modified="2010-10-05" version="1">MENINYFIQSPVASVIFILTIGLSLYLFSNQHLFGKLMLHPYSVYRKHRVYTIFTSGLIHKDWGHLLFNMITFYYFGFGLESIFAGISVWGHFLFAILYLLSLILSDIPTIVQQKNNPGYYSLGASGAISAVLFGYILFDPQAELGIFFVIPMKAYLFAVLFMGYSYWASRKANDGINHSAHLFGALAGLLLTVLFFPDVIQHFMRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIC7</accession>
    <name>D7VIC7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10746"/>
    <dbReference type="EnsemblBacteria" id="EFK59829">
        <property type="protein sequence ID" value="EFK59829"/>
        <property type="gene ID" value="HMPREF0766_10746"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032TSP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129146_0_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030153">
        <property type="term" value="P:bacteriocin immunity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009589">
        <property type="entry name" value="SunI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06713">
        <property type="entry name" value="bPH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="146" mass="16787" checksum="6FCD3F6A8EC65572" modified="2010-10-05" version="1">MIFKSRKDPLVLGVIFTCCITIIIFLLIMYIKEGATLFQILISLIPALTAIGILLWMTFRIQYIIGPDYIDCVAGFYKERIKINAIRRIDTDTTMWMGLKLAGARKGIIIYYHTYAEIYLSPDTYEQFISELLKVNPAIEIHKKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VID2</accession>
    <name>D7VID2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998130.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10751"/>
    <dbReference type="EnsemblBacteria" id="EFK59834">
        <property type="protein sequence ID" value="EFK59834"/>
        <property type="gene ID" value="HMPREF0766_10751"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZA2J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_825824_0_0_10"/>
    <dbReference type="OrthoDB" id="1391282at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="360" mass="40753" checksum="AC2ABF5F40F2EDDF" modified="2010-10-05" version="1">MDKTIPEFKDFALILAWPDSTIRGDEAWMMFFKKIGIVKNLNFKVGHTGIVLISAASGELLYYDFGRYISPRGHGRARSKESDPRLAINFKARFDEHGKISNLENIVHHFESMREDMQGFGELYFSVAEDINFDQAKNYADRIVLQGSTPYGAVARGNNNCSRFITRLLFNSSQKYTWLHSINFPETIKSSPISNVVNANHCRSVYSYSPANGLKNFRMSRWQSFLFLLSKLADNVRSKKAALLPDDLIIGGMEYDSKPASIPEESQYLGGVGEGAWYAFRVMGNQQIIVSRYTPTGQWEYSVVGVADPALDPEQPFQITYDSHLLTTQVIQHGVKLNIRHVKRLSNSELPFPRTAEQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIG1</accession>
    <name>D7VIG1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">STAS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ychM</name>
        <name evidence="3" type="ORF">HMPREF0766_10780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998189.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10780"/>
    <dbReference type="EnsemblBacteria" id="EFK59863">
        <property type="protein sequence ID" value="EFK59863"/>
        <property type="gene ID" value="HMPREF0766_10780"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_7_0_10"/>
    <dbReference type="OrthoDB" id="967266at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015116">
        <property type="term" value="F:sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="2">
        <location>
            <begin position="411"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="510" mass="54699" checksum="D488027932CF0E20" modified="2010-10-05" version="1">MNSFLQFFDFKQKVNYRVEILAGLTVAMTMIPESLSFAILAGLSPLTGLYAAFLMGLITAVLGGRPGMVSGGAGATVVVLIALAATHGVEYLFAAIILGGVLQFLVGLFRWGKFVRLIPQPVMYGFLNGLAIIIFMAQIHQFKVVENGVSHWLSGAALYTMIGLTVLTMLIVYFFPKLTRTIPASLVAIMVIFAIVLAGSIETKTVSDIASVSGSLPVFHIPSVPLTWDTLQLIFPYALVMAGVGLIESLLTLSMVDEITNTKGNSNREAMAQGTANLVNGFFGGMGGCAMVAQTLVNLNAGSRARLSAIIGAATILIIILIGSPVIERIPMAALVGVMIMVSIGTFQWVSVRLVNKMPKSDIFVGVLVAAITVLLHNLALAVLVGVIISALVFAWDNAKRIRARKSIDAEGNKIYEINGPLFFGSAAHFAEKFDVAEDPDQIIIDFKESRLVDMTAIDVVHKLTAKYAENGKRVILRHLSADSRKLLADAAGLIEVNVEDDPTYKVMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIJ5</accession>
    <name>D7VIJ5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998253.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10814"/>
    <dbReference type="EnsemblBacteria" id="EFK59897">
        <property type="protein sequence ID" value="EFK59897"/>
        <property type="gene ID" value="HMPREF0766_10814"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503444E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_17_15_10"/>
    <dbReference type="OrthoDB" id="1964925at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="96" mass="11019" checksum="446A43287DAAE1F5" modified="2010-10-05" version="1">MEIGEYIRIKRENLKVSQEAVAFKLDMSQAAYSKIERGETKVKVDQVYKIAHLFGISVYELLPPSLASDVTKENTFGLIWYAIKWSFYKIKGLVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIK5</accession>
    <name>D7VIK5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-O-beta-D-mannosyl-D-glucose phosphorylase</fullName>
            <shortName evidence="4">MGP</shortName>
            <shortName evidence="4">Mannosylglucose phosphorylase</shortName>
            <ecNumber evidence="4">2.4.1.281</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_10824</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man-Glc) to mannose 1-phosphate (Man1P) and glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate = alpha-D-mannose 1-phosphate + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32531"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:64351"/>
            <dbReference type="EC" id="2.4.1.281"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the glycosyl hydrolase 130 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.281" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998271.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10824"/>
    <dbReference type="EnsemblBacteria" id="EFK59907">
        <property type="protein sequence ID" value="EFK59907"/>
        <property type="gene ID" value="HMPREF0766_10824"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046648_4_0_10"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00928">
        <property type="entry name" value="Man_Glc_phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028583">
        <property type="entry name" value="Man_Glc_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016202">
        <property type="entry name" value="PH1107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="401" mass="46126" checksum="D571E89CF5DE7D96" modified="2010-10-05" version="1">MSQQNNMRGDFFKQRRALLFDRHEELLTRTNIPQSDFNGIINRYQYPVISKHHIPLNWRYDLNPETNPYFLERIAVNSTLNAGAIKWQGRYLLLVRVEGVDRKSFFAIAESPNGIDNFRFWERPLSFPDNDEQETNVYDIRLTAHEDGWIYGIFCSEKHDPKASSGDLSSALASAGIIRTKDFMHWERLPNIRADNQQRNVVLHPEFVNGKYALYTRPQDDFILAKNGGGIGWALTEDICHAVIQNEIIINKRHYHTIKEVKNGEGPSPLKTAKGWLHLAHGVRHTAAGLRYVLYLYVTSLTNPEILIAEPAGYFMAPEQDERIGDVSNVLFSNGWIADENGTVYIYYASSDTRMHVAVSTIDQLLDYCLHTPQDGLRTIESIKKINELIDKNNIYKQQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIT7</accession>
    <name>D7VIT7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sporulation and cell division repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998446.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10906"/>
    <dbReference type="EnsemblBacteria" id="EFK59989">
        <property type="protein sequence ID" value="EFK59989"/>
        <property type="gene ID" value="HMPREF0766_10906"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106289_0_1_10"/>
    <dbReference type="OrthoDB" id="1782982at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106940" evidence="1">
        <location>
            <begin position="22"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="SPOR" evidence="2">
        <location>
            <begin position="71"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="153" mass="17783" checksum="7D1C0588BBAE488C" modified="2010-10-05" version="1">MYKKGLILFFLMFGCAVFAKAQQSGRVEVFKDSLISVLQAYRSEEGINPSLEKKTVSIGKISVVDKSKMKRVKVRGFRVQIFSGASRNEAYAEQGRFKNLYKEYEAYVNYDEPNYRVKVGDFTSRSEANNLMRILRSQFDNVFVFTEDVYVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIU7</accession>
    <name>D7VIU7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="6">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">nadD</name>
        <name evidence="8" type="ORF">HMPREF0766_10916</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NadD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998466.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10916"/>
    <dbReference type="EnsemblBacteria" id="EFK59999">
        <property type="protein sequence ID" value="EFK59999"/>
        <property type="gene ID" value="HMPREF0766_10916"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069765_3_3_10"/>
    <dbReference type="OrthoDB" id="1433958at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="6"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="192" mass="22231" checksum="E7775E9A9DC72FC4" modified="2010-10-05" version="1">MKKVGLFFGSFNPVHIGHLIIANYMANHTALDEVWFVVSPQNPFKKKASLADPYDRLEMVNMAIEDTENLRCSNIEFNLPVPSYTIDTLVHLSEKYPDKQFHLIMGQDNLESLQKWKNIDIILRDYHIYVYPRPGYNSGDMKDHPSITLTDTPLMELSSTFLRKAILEGKDIKFFTPDKVIEFIDKKGLYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIZ7</accession>
    <name>D7VIZ7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998565.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10966"/>
    <dbReference type="EnsemblBacteria" id="EFK60049">
        <property type="protein sequence ID" value="EFK60049"/>
        <property type="gene ID" value="HMPREF0766_10966"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50343BV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2828994_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="67" mass="7117" checksum="A3C72E78FE3482F6" modified="2010-10-05" version="1">MENHIENTEETALNVPGLIILIGVIFGALTVLAWNLSILGAIGGAIGGFIFAVIFISFLLKGKPHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ11</accession>
    <name>D7VJ11_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002094.1">
        <property type="nucleotide sequence ID" value="NZ_GL379779.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10980"/>
    <dbReference type="EnsemblBacteria" id="EFK59146">
        <property type="protein sequence ID" value="EFK59146"/>
        <property type="gene ID" value="HMPREF0766_10980"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033KG7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1719098_0_0_10"/>
    <dbReference type="OrthoDB" id="2044384at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="161" mass="18089" checksum="9F079FB9A1EF052A" modified="2010-10-05" version="1">MERKKVFGLMIILCLCLGIAQAQQIDERRMKIEMTVRQGNEEIIAALTSATISFNRGLNENLVSDSLSRQGTNKENVRLYDIGIALDRQNIKLLSAFVKNKKGLNGHIILTDTYKKLPSRKIEFTSAVLDALNDQFTNDYSSAYMSIRCGTLMIDGLDIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ28</accession>
    <name>D7VJ28_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10997"/>
    <dbReference type="EnsemblBacteria" id="EFK59163">
        <property type="protein sequence ID" value="EFK59163"/>
        <property type="gene ID" value="HMPREF0766_10997"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3205429_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="45" mass="5463" checksum="BFE752803215594D" modified="2010-10-05" version="1">MMLIILRYRKLSYTYFSFLKRFGLRAVISPYNRNYIPGKNISDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJK2</accession>
    <name>D7VJK2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000700.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11171"/>
    <dbReference type="EnsemblBacteria" id="EFK59055">
        <property type="protein sequence ID" value="EFK59055"/>
        <property type="gene ID" value="HMPREF0766_11171"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032SAW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106614_0_0_10"/>
    <dbReference type="OrthoDB" id="1739979at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025665">
        <property type="entry name" value="OMP_b-brl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13568">
        <property type="entry name" value="OMP_b-brl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107215" description="OMP_b-brl_2 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl_2" evidence="2">
        <location>
            <begin position="22"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="209" mass="23030" checksum="C1FBBFC499EBD1C1" modified="2010-10-05" version="1">MTFTFRYLLISLFVLCSSGAFAQGYGDRNISLGLTVNPNMGLFRFDEDSNVDGKSKAGFSYGLIADIGFARNYYFSTGLQINTIKGRLEYPQNSSFPNKDVRLQYAEIPLTLKMKTSDINSRRFYGQFGFTTGIKVSSKESLDGTDKTTGVDGSSLLRLGLLIGGGLEWRFDNNLSIITGLSYNNGFTKAFNEGKPKASYLGLNLGLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJQ6</accession>
    <name>D7VJQ6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Urocanate hydratase</fullName>
            <shortName evidence="9">Urocanase</shortName>
            <ecNumber evidence="4 9">4.2.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Imidazolonepropionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">hutU</name>
        <name evidence="13" type="ORF">HMPREF0766_11225</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>4-imidazolone-5-propanoate = H2O + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:13101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="4.2.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="9">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the urocanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.49" evidence="4 9"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000827.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11225"/>
    <dbReference type="EnsemblBacteria" id="EFK59109">
        <property type="protein sequence ID" value="EFK59109"/>
        <property type="gene ID" value="HMPREF0766_11225"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2987">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018868_3_0_10"/>
    <dbReference type="OrthoDB" id="100619at2"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00577">
        <property type="entry name" value="HutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023636">
        <property type="entry name" value="Urocanase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035400">
        <property type="entry name" value="Urocanase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="PTHR12216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17391">
        <property type="entry name" value="Urocanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001423">
        <property type="entry name" value="Urocanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="SSF111326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01233">
        <property type="entry name" value="UROCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="7 9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase_N" evidence="11">
        <location>
            <begin position="85"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase" evidence="10">
        <location>
            <begin position="213"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase_C" evidence="12">
        <location>
            <begin position="436"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="125"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="587"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFK59109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="666" mass="74689" checksum="1466658C05A68B8D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJX2</accession>
    <name>D7VJX2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11291"/>
    <dbReference type="EnsemblBacteria" id="EFK58574">
        <property type="protein sequence ID" value="EFK58574"/>
        <property type="gene ID" value="HMPREF0766_11291"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044440_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="315" mass="35584" checksum="E42BC174EF0A4CE9" modified="2010-10-05" version="1">MKRIICFALLGMAINGVYSQQQLIMEDSRGIASTPVHYNFKLKPSFKYNTDIGLNVSGNYSTVLGMRGWWDDSGGKAHELAFTDNDLYIRSGYDSGWEAWRKMVTADANGYVGIGTSNPQTFLTLKNQTNDKDYISIIRTDDSPNMDIFSSYSGSDDIQSGYFAYGVRPVDDAWQIWNKTTGISWVNLVSVKANGNVGIGTATPQDKLAVNGNIRAREIKVETTNWPDYVFEEEYKLTPLAEVETFIKANKHLPDVPSAKEIEEEGLSVGEMNKLMMKKIEELTLHLIEKEKTQKLYEQQLADMAERLKKIEEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK20</accession>
    <name>D7VK20_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998849.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11339"/>
    <dbReference type="EnsemblBacteria" id="EFK58622">
        <property type="protein sequence ID" value="EFK58622"/>
        <property type="gene ID" value="HMPREF0766_11339"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_2_10"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="170" mass="19653" checksum="30C2595FF504B31E" modified="2010-10-05" version="1">MIRLVPFQQSNFEQLIRMVPDEELLVQFAGFIFSFPLTCQQLDFYLSDPDRLAFAVFTLSENRYIGHAELYKSEHNHYKICRVLIGTPGDRGKGFGSALIQALCRYAFHDLQAEEVELNVFDWNDAAIHCYQKNGFSFRPENNKIIESSNGQMLNSLNMILKKELFNKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK46</accession>
    <name>D7VK46_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998919.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11365"/>
    <dbReference type="EnsemblBacteria" id="EFK58648">
        <property type="protein sequence ID" value="EFK58648"/>
        <property type="gene ID" value="HMPREF0766_11365"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1730233_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="178" mass="20488" checksum="73BEF1C2FD54D701" modified="2010-10-05" version="1">MKSIVTIAIAGLLCYFIFRCINTSAQAGRTADNRLQMRMHAAYMYFGYCCLMICAGIVGGVIYDYPKIDAVAAVLAISIFLLFGVLGVYNLKLYYVHTVLYNEDHITCYNTRGKAKVFYWKDIRHAVYNGYTGSIRLYSSRKEHIIIHHDLGGIDDFYQEFYRQKPHIAQKVKIRILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK60</accession>
    <name>D7VK60_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nagZ2</name>
        <name evidence="8" type="ORF">HMPREF0766_11379</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998955.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11379"/>
    <dbReference type="EnsemblBacteria" id="EFK58662">
        <property type="protein sequence ID" value="EFK58662"/>
        <property type="gene ID" value="HMPREF0766_11379"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007082_5_1_10"/>
    <dbReference type="OrthoDB" id="727559at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107601" description="Beta-N-acetylhexosaminidase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20b" evidence="7">
        <location>
            <begin position="21"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="6">
        <location>
            <begin position="151"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="545" mass="63355" checksum="CF4CA5438510BEE8" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK66</accession>
    <name>D7VK66_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase family M1</fullName>
            <ecNumber evidence="2">3.4.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pepN2</name>
        <name evidence="2" type="ORF">HMPREF0766_11385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998974.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11385"/>
    <dbReference type="EnsemblBacteria" id="EFK58668">
        <property type="protein sequence ID" value="EFK58668"/>
        <property type="gene ID" value="HMPREF0766_11385"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042033_0_0_10"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M1" evidence="1">
        <location>
            <begin position="275"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="410" mass="48048" checksum="CD13E9114CB3CEC3" modified="2010-10-05" version="1">MKNLVKTSVLSFLLLPVCILITHISKAQKITHYEGKVAIDSLKNIIAAFNISYLNGDKNELDFYLNKNADIKQFRFGNNSVEYTIEGVVEDLKRIRIKNTFPEKFVLNIEYTYPLDKIESKIFAYNPNWIELSLYTGWFPVNIDDKNYSYQLNFKVPENYDIIGNGVVRKKGLNTIITNTNNHFDIPVVLSGKFQRFSTRNNKIKFFSVQLPAEKIEEIQETSLEMYNFYESRFGKSATDNLIVTVNPFAHDMSYARRGFISLSLLDNYGLVDRKVLAHEIAHLWWQNAKTGVWEDWLNESFAEFSTLKWMEKTLSDEIFQKQLKKYEDAYKKPVKVSKTKTGDTDWHSVAYFKGPYMLYQLEKNIGEEKMLQFLKKVYKDKISTTEKLIELLKHYADEKSVKILENEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK80</accession>
    <name>D7VK80_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11399"/>
    <dbReference type="EnsemblBacteria" id="EFK58682">
        <property type="protein sequence ID" value="EFK58682"/>
        <property type="gene ID" value="HMPREF0766_11399"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037682_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009446">
        <property type="term" value="P:putrescine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007466">
        <property type="entry name" value="Peptidyl-Arg-deiminase_porph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377">
        <property type="entry name" value="PTHR31377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04371">
        <property type="entry name" value="PAD_porph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="350" mass="39600" checksum="E1AAB553F9AE0C6A" modified="2010-10-05" version="1">MMNPVSPVDSAVLYRMPEESALHEGTWLQWPHEYLYGRTFRDRLDETWVAMTKALVNSEKVHIIVYDNIELERVSALLKKAQISLAYVEFTIARTDDVWIRDNGPIYVKDNNGKLLVEDWGFNGWGEKADYENCERIPSQLAADKNMQSINLNDIMINEGGSVEIDGNGTLMACKSSVLNKNRNPGMTQQQAESIFTKYLGTTHFIWLEGEAGLDITDIHIDGFARFADKSTIITMADDDLLYWQVPEHDITTLYEAVNRDGQPYNFVNVPLTKNDVTTTYGKNVGKASYINYYIGNTVVLVPNYNDPNDTVANAIIQKHYPGRKVIGIDCRNLFANGGMVHCVTQQQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKA2</accession>
    <name>D7VKA2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
            <ecNumber evidence="2">3.4.17.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ammA2</name>
        <name evidence="2" type="ORF">HMPREF0766_11421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999064.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11421"/>
    <dbReference type="EnsemblBacteria" id="EFK58704">
        <property type="protein sequence ID" value="EFK58704"/>
        <property type="gene ID" value="HMPREF0766_11421"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023257_0_1_10"/>
    <dbReference type="OrthoDB" id="796259at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="191"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="396" mass="43789" checksum="21171BE97BF468DF" modified="2010-10-05" version="1">MKDQINIHLAALTDDIVTWRRHLHQHPELSFQEYETTRYITDMLTQLAIPFRSVSETGVIGFINGNGKSDRTLALRADIDALPITEENDVVYKSLHTGIMHACGHDFHTATLLGVATILKKMEQQLDGNIILIFQAAEEKIPGGAQAVIASGVLDVPNLIGVIGQHVSPKIEVGKFGYRAGKFMASSDELYIDIKGKGGHGAQPHLNIDPVSISAQLIVTLQQIVSRYANPAIPTVLSFGKVIANGAANVIPDTVHLEGTFRTMDESWREKALSLMENIIKELPQTLGAEVEVEIRRGYPALFNNELLIQKIKKAALSVFAPEQITETDLWMAAEDFAYYAKHYPAAFYLIGTKCPEKNLTAELHNPHFNIDEDILPESVRMMTNVAVTLINDKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKB8</accession>
    <name>D7VKB8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11437"/>
    <dbReference type="EnsemblBacteria" id="EFK58720">
        <property type="protein sequence ID" value="EFK58720"/>
        <property type="gene ID" value="HMPREF0766_11437"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2920438_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="61" mass="7094" checksum="B7DD5A3259DBDF20" modified="2010-10-05" version="1">MRLLLFSPALQKKDIPRRIETYISNWRGRQLTLRDVIKSLNSKVDINNCSQLRLLLSSPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKF0</accession>
    <name>D7VKF0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11469</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999198.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11469"/>
    <dbReference type="EnsemblBacteria" id="EFK58752">
        <property type="protein sequence ID" value="EFK58752"/>
        <property type="gene ID" value="HMPREF0766_11469"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_28_1_10"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="840"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="1090"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="1237"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1336" mass="151623" checksum="7D6FFB8AAA6CBE7A" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKF7</accession>
    <name>D7VKF7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metal cation transporter, ZIP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_11476</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999215.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11476"/>
    <dbReference type="EnsemblBacteria" id="EFK58759">
        <property type="protein sequence ID" value="EFK58759"/>
        <property type="gene ID" value="HMPREF0766_11476"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099364_0_0_10"/>
    <dbReference type="OrthoDB" id="1469769at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="261" mass="28541" checksum="F1957F72557B4CCB" modified="2010-10-05" version="1">MSATLIIAILFISALSSGIAVFFVKRDNTSNLKLILSFSGAYLFAITVLHLIPHVYQASNTDPEIIGLYVLGGFLFQLVLEQFSQGIEHGHIHNHGHQAFPIGIMISLCLHAFLEGMPLASAHQSELVFGIAIHHIPAAFALGSLLLNTKLTKTKISVFIIIFAAMTPLGFLLSKGISAGEVGNIQLYFDKIMAVVIGIFLHISTTILFESGSADHHHFNKKKMIAVALGVAVSLFNFLFDSHDHADHKGHDHTEQHDHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKG1</accession>
    <name>D7VKG1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11480"/>
    <dbReference type="EnsemblBacteria" id="EFK58763">
        <property type="protein sequence ID" value="EFK58763"/>
        <property type="gene ID" value="HMPREF0766_11480"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2025262_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="122" mass="14139" checksum="06C512F46598C51E" modified="2010-10-05" version="1">MDKDAVLIHIPQKNISIFSKYFFSICRGHRERGVYALGCVVKVWKQWEGCYKKRELVLAPSVDSYCCFADSFTLQQAPLEHPQPPLDEPFILRYRKITAAIKTTAIILYCIISFVIIVYFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKJ4</accession>
    <name>D7VKJ4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11513</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999326.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11513"/>
    <dbReference type="EnsemblBacteria" id="EFK58796">
        <property type="protein sequence ID" value="EFK58796"/>
        <property type="gene ID" value="HMPREF0766_11513"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_106_2_10"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="556"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="401"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="751" mass="86599" checksum="C665728835F3702F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKK9</accession>
    <name>D7VKK9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999355.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11528"/>
    <dbReference type="EnsemblBacteria" id="EFK58811">
        <property type="protein sequence ID" value="EFK58811"/>
        <property type="gene ID" value="HMPREF0766_11528"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105055_0_0_10"/>
    <dbReference type="OrthoDB" id="1674960at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="62"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="217" mass="25265" checksum="AE1B432FDA3099E1" modified="2010-10-05" version="1">MIPKNLLIQVIDQLDEYCAQYPEDLTYEGFASFVHVNRLSQNTVTRQVGGDYVPIMERDMPAEDIGKLLVMLYRYAKNYIKIAFAGTPLQTPEEFTYLMVLFTYDKLPQSELIRKNIMEKASGNEVIKRLMRMGMIMEAERSGDKRSKPISISPMGRKVLIDMLPKMRMVGNVVSGNLNQTERQLLIYLLAKLDHYHHDQYGHKDKQELEDYLHKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKU5</accession>
    <name>D7VKU5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cardiolipin synthetase</fullName>
            <ecNumber evidence="14">2.7.8.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cls</name>
        <name evidence="14" type="ORF">HMPREF0766_11614</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="14"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999513.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11614"/>
    <dbReference type="EnsemblBacteria" id="EFK58897">
        <property type="protein sequence ID" value="EFK58897"/>
        <property type="gene ID" value="HMPREF0766_11614"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038053_1_2_10"/>
    <dbReference type="OrthoDB" id="1881748at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008808">
        <property type="term" value="F:cardiolipin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022924">
        <property type="entry name" value="Cardiolipin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04265">
        <property type="entry name" value="bac_cardiolipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFK58897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="497" mass="56854" checksum="AA1CC060F50250C2" modified="2010-10-05" version="1">MEVLAIESHHVNMVWEFLVQWYWIPLSILYIGVISTILIENRNPSKTVSWVMVIVFLPVIGLILYYLFGQKFQKIRKFQRMSQQQAELLEREWNKLEPEMERDLETIEEWIGSAHRVFTFLKNERLSSPSLRNRVTLLTNGEEKFPAFLKAIREAKHAIHVEYYIFELDSIGLEVLNALEEKAAEGIKVRLIVDSFGSPDLVKYLVASKKSKIEFQPFLPVTFTSLANSNYRNHRKIAVIDGHIGFVGGINISDRYINYPGQSDAVFWRDTSVMIEGEAVNMLQVNFWMSWNQTDGDPFMITREYLCSKPFQFPEQAAVAFTSSDPGSVGPFNMEAILLAISEAKNRVQLCTPYYIPSDELSTALQVAAASGVEVELMMPAKSDSYFVQHASFSFLKSLLNRGVKVYLYNKGFIHAKTLCIDGKVAFIGTTNLDIRSFYINFEISAIISDLQLCVNLENQFELDKADSDLLTLKIWKNRSKWKKGVDSLCRLLAPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKZ7</accession>
    <name>D7VKZ7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Excinuclease ABC, A subunit</fullName>
            <ecNumber evidence="15">3.1.25.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">uvrA</name>
        <name evidence="15" type="ORF">HMPREF0766_11666</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.25.-" evidence="15"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999664.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11666"/>
    <dbReference type="EnsemblBacteria" id="EFK58270">
        <property type="protein sequence ID" value="EFK58270"/>
        <property type="gene ID" value="HMPREF0766_11666"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001370_0_2_10"/>
    <dbReference type="OrthoDB" id="152379at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="614"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="646"/>
            <end position="653"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFK58270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="946" mass="105655" checksum="CC9098AF4D3A248E" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL72</accession>
    <name>D7VL72_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative gliding motility-associated lipoprotein GldK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999830.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11741"/>
    <dbReference type="EnsemblBacteria" id="EFK58345">
        <property type="protein sequence ID" value="EFK58345"/>
        <property type="gene ID" value="HMPREF0766_11741"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_10_1_10"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="433" mass="49740" checksum="5E3A506D34DFC8CB" modified="2010-10-05" version="1">MNYNLFKVLTLAVMGSLLISSCKGPGNNGELLGVRLDKLKANKTPYGMVLIPGGTFIMGQSDEDITFSQVSQNRQVTIAPFYMDDTEISNSEYRQFVNWVRDSILITNFLGDDSYFIQNQGTTPTSGERHIDWNKVQSKSPWKTKDQTQRERVNSMYYQGEDRIFGKNEIDVRLLKYHYEWYDLRRAIAAKNDPSRSRSEFIMRDTILVYPDTTVWVSDFSYAQNEPMVEGYFSHPSFDEYPVVGVTWKQAQAFNTWRTRLFNNAAAKNREVERMPYQLPSEAEWEYAARAGKNGMQYPWGGPSARNARGCLMANFKPGRGNYIDDGAAYTAPVYSYWPNDFGLYNMAGNVAEWTQSSYDESAYSFVHDMNPTYAHSAKASDQNAMKRKVVRGGSWKDIGYFLQNSTRQYEYQDTAKSYIGFRSVTRYTGVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLE0</accession>
    <name>D7VLE0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polysaccharide deacetylase</fullName>
            <ecNumber evidence="6">3.2.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">egl</name>
        <name evidence="6" type="ORF">HMPREF0766_11810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000037.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11810"/>
    <dbReference type="EnsemblBacteria" id="EFK58413">
        <property type="protein sequence ID" value="EFK58413"/>
        <property type="gene ID" value="HMPREF0766_11810"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006010_1_0_10"/>
    <dbReference type="OrthoDB" id="1226595at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02850">
        <property type="entry name" value="E_set_Cellulase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004197">
        <property type="entry name" value="Cellulase_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02927">
        <property type="entry name" value="CelD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="5">
        <location>
            <begin position="619"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="833" mass="95213" checksum="75465E9F585A550F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLE8</accession>
    <name>D7VLE8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000059.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11818"/>
    <dbReference type="EnsemblBacteria" id="EFK58421">
        <property type="protein sequence ID" value="EFK58421"/>
        <property type="gene ID" value="HMPREF0766_11818"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025928_3_0_10"/>
    <dbReference type="OrthoDB" id="319098at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041662">
        <property type="entry name" value="SusD-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12771">
        <property type="entry name" value="SusD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="534" mass="60231" checksum="875B779DBE554C3F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLH3</accession>
    <name>D7VLH3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibronectin type III domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yngK2</name>
        <name evidence="3" type="ORF">HMPREF0766_11843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000130.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11843"/>
    <dbReference type="EnsemblBacteria" id="EFK58446">
        <property type="protein sequence ID" value="EFK58446"/>
        <property type="gene ID" value="HMPREF0766_11843"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019247_2_1_10"/>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003790">
        <property type="entry name" value="GHL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02638">
        <property type="entry name" value="GHL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="411"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="508" mass="59266" checksum="1D04C61169F2431A" modified="2010-10-05" version="1">MLHFRKIIILILFISHFPYKAISQNSPKRELRGVWIATVANIDWPSRDNESSERQKQELINILDAHQRAGLNAIFFQIRPAADAFYAKGREPWSRYLTGVQGKAPSPFYDPLEFVIEEAHKRGMELHAWVNPYRASTTLNPAHFSKDHITRTKPEWFFKYGGKYLFNPGLPEVRQYIIDVIMDVVKNYDVDGIHFDDYFYPYPDARNTALPDAPTFHQFGKGFANIHDWRRNNVDLLIRDLGIAIKKEKPFIKYGISPFGIWDNKRDNPDGSNTSGLSGYRTLYADGVKWMKEGWIDYINPQIYFPFNNRAAAFEILLEWWEKHTYGRHFYVGHGAYRVTEKRPGWTDKGQIPKQVRHLRDQHEVQGSIYFSSKSLMDNLAGLRDSMQYDLYRYKALPPTMAWIDSIPPQSPYGLQAHVSSNRKSTTLVWQKPNDEQIYGYIIYRFEKGENVNTANAERILQISYDDSYLQYTDNTIKPGGHYFYVVTAIDRMKNESSISNIREVILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLI8</accession>
    <name>D7VLI8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000161.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11858"/>
    <dbReference type="EnsemblBacteria" id="EFK58461">
        <property type="protein sequence ID" value="EFK58461"/>
        <property type="gene ID" value="HMPREF0766_11858"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026911_5_2_10"/>
    <dbReference type="OrthoDB" id="564091at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="498" mass="56661" checksum="D683611E2307E31E" modified="2010-10-05" version="1">MESLREENNNTREEPSLKQKTAKGLLWGGMSNLIQQLLGAFFGVYVSRILTPEDYGAVAVLLIFPVLASTLQESGFVSAITNQKQVEHKDYNAVFWFSGFIGLSLYIILFFCAPLIAYFYDMPELTPLARYLFLSFLISSMGTAHNAYLFRNLKVKQRAIGTTIALIISGITGVVMAYNGKAYWGIATQTVLYVLVNTTFLWIFSSFRPTFHFDFSPIKKMFAFSSKVLITNLFLQFNTNIITTILGKFYTKSDAGAFNQANKWNIMGQSVLLGMSRSVAQPILTSVHEEEERQLRVFRKILSFTAFMTFPLIFGLSSVAKEFIEIFLTNKWQNSAYFLELLCIGGAFVPLADIYANLALSKGKSNIYMWNVIALSLTQLVLFLLVYPYGISSMILVYVITNILWLFVWHYFVSNQIGLKWKYLFSDVFLFAAIASVAIAGTYLITMDLTLHLYIHFILKIVLTALLYTTLVWFIRPQLVKECITFLKLDKFFKSKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLJ0</accession>
    <name>D7VLJ0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_11860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000165.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11860"/>
    <dbReference type="EnsemblBacteria" id="EFK58463">
        <property type="protein sequence ID" value="EFK58463"/>
        <property type="gene ID" value="HMPREF0766_11860"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054735_1_0_10"/>
    <dbReference type="OrthoDB" id="1931172at2"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004139">
        <property type="entry name" value="Glyco_trans_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03071">
        <property type="entry name" value="GNT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="305" mass="35635" checksum="45E6DC5761D3F912" modified="2010-10-05" version="1">MEKKLAPVVLFVYNRPLHTEQTLAALEKNLLASESDLFIYADGARNKEAETQVAAVSKIIHRVWPFRSVTIIQRNRNWGLAPNVIDGVTTIIRKYGKVIVLEDDLKTAPNALQYFNDALNQYESEPQVMSVSGYNYPLKEADTLPETFFFRVTNSWGWATWDRAWKHFNPDIESMVQQLNQEQIYQFSIEGKENFWRQVQQFRKGKINSWAIRWYLSVFLQKGLTLYPRHSYIQNIGTDGSGTHSDAEQTYKVRLNEEKTTSFPEKIEENAVAYEHIKDFYAHRKGSLFQRGIRFAKKRINKLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM24</accession>
    <name>D7VM24_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001228.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12021"/>
    <dbReference type="EnsemblBacteria" id="EFK58029">
        <property type="protein sequence ID" value="EFK58029"/>
        <property type="gene ID" value="HMPREF0766_12021"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50314VA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1299090_0_0_10"/>
    <dbReference type="OrthoDB" id="1818671at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107043" evidence="1">
        <location>
            <begin position="23"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="212" mass="24348" checksum="25396380F5C73BAE" modified="2010-10-05" version="1">MKKLSTLFVLFILSICTFTSTAKTAVRCVKYCETALLNEDTTLDYYPFKDSTYVLSVKPSQNPDAPDTVIYMRKTSGNTSTVLWKELLLLPQAIDFRSEDFNGDGQEDVLIYAGTGARGANEFYHLYVADPERHTLIRIQGFEEIPNTVYLPDYNIIVGYAYSGENYYIVYRIDKNNVVQQMGDSFKDDFDSDQEDFDKRIKTILNAEKEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM26</accession>
    <name>D7VM26_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001233.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12023"/>
    <dbReference type="EnsemblBacteria" id="EFK58031">
        <property type="protein sequence ID" value="EFK58031"/>
        <property type="gene ID" value="HMPREF0766_12023"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033T61">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_690477_0_0_10"/>
    <dbReference type="OrthoDB" id="2121152at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="404" mass="46525" checksum="CDB8239CCA2D35BD" modified="2010-10-05" version="1">MENLMTTANIKALILSLLILIFTYWYYSTQQPSFLSFGTAVFATFISLILILLVACIIRGLDHLIVSQLIYPHILFRFLQPFLILLLLFWLGYGIFCIASFGYSNEFSSSVKQFFRLHLPYITIVCILLAIGLSLPFQSQKISVGALFYNNIKFALCVAGIVVVSVFLIYWIKLIKQPDLGTKFVLYQTLDNQFDLDGVEVKMLLDAGKQHHASEPYFLPDRNELIINILSESSNKTPPLQKSYKVDKEGKIIADLDTDAQFAGAQGPFTFEDGYIKANQADQLVTWVYDGNKEIRDISSFSAPHNRTITRLTPDQNQPKAEYFYKTSKIRCADTEVKWNGTRYYTIAYQGDTVRFKINNVYMQNSTQKECTEQKVEYFECKGMNFDLIRLNEQVYYTLKQKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMD0</accession>
    <name>D7VMD0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome C family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_12127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001456.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12127"/>
    <dbReference type="EnsemblBacteria" id="EFK58135">
        <property type="protein sequence ID" value="EFK58135"/>
        <property type="gene ID" value="HMPREF0766_12127"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093848_2_1_10"/>
    <dbReference type="OrthoDB" id="1939800at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107338" evidence="5">
        <location>
            <begin position="22"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="32"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="141" mass="15693" checksum="5CD34CBCFC5ED7E2" modified="2010-10-05" version="1">MKLLTVLSCLAAVYLISLLNACQPNVSIQTAQYAVNGQKLYSTHCQNCHGAKGEGLGKLYPPLTDAKYFKDNRKILPCIIKNGISGPIKINGETFNEKMPGLPELTEVDIAYILTYITTTFAQETEKYSQEEVRMNLQNCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VME3</accession>
    <name>D7VME3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter, major facilitator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_12140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12140"/>
    <dbReference type="EnsemblBacteria" id="EFK58148">
        <property type="protein sequence ID" value="EFK58148"/>
        <property type="gene ID" value="HMPREF0766_12140"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_23_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="27"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="410" mass="44602" checksum="E6720262DEB70578" modified="2010-10-05" version="1">MLSGNRKTHLKKKNMSINTKPLLTPSLLWLMAIGSGLVVANNYYNQPLLALMAKDFNVSEASISNIAMLTQIGYACGLLFIVPLGDMVRRRNLILIDFIFIIASLIGMAMTKSVDWLFPLSFMVGFTSVVPQIFVPMAAELASPDKRSSAIGMVMSGLLIGILLSRVVSGIIGDYFGWREMYWAAAGCMVVLSILIAVKLPENSPSFTGSYMDLMKSLGRLTRTQPVLRLAAFRGAMGFAGFSAFWTTLVFHMEGAPFHDGPAVVGSFGLVGAAGALGAAFVGRFTGRFTSFQIILYAIIMMIVSWIVFYFGGYTYGGLIIGIILVDLGLQSMHIMNQSSYFALNLGANNRLNTVYMVSYFIGGSTGTYLAAQAWNYQQWTGVVAVGIFFTALALAAHLIFDKKINNKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMG4</accession>
    <name>D7VMG4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001512.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12161"/>
    <dbReference type="EnsemblBacteria" id="EFK58169">
        <property type="protein sequence ID" value="EFK58169"/>
        <property type="gene ID" value="HMPREF0766_12161"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050017_0_0_10"/>
    <dbReference type="OrthoDB" id="1452706at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107342" evidence="1">
        <location>
            <begin position="30"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1080" evidence="2">
        <location>
            <begin position="34"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1080" evidence="2">
        <location>
            <begin position="252"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="463" mass="51268" checksum="A1CF4E22F91AD341" modified="2010-10-05" version="1">MTHTKLSSISKILMATGCLLASATFTTQAQQTKATPIFDGKTLAGWKTVGGKAPYVVENGVIVGTMTKKTPNSFLVTEKEYGDFILELEVKLEGDNTNSGIQIRSHIDPQANDGRGRMYGKQVEVDPTARAWTGGIYDEARRGWLYPLDLNQNAKKAFRKNEYNAIRIEAIGDEVRTWVNGIPTAAVIDTIDRTGYIGLQVHNIADADDGKKVYFKNVRIQTENLKSKAFPKDIYITNLHLNQLSQAEQQNGYKLLFDGKSTAGWHSARGKEFPSKGWEIKNGTISVLSSTGGESTNGGDIVTDAQYKAFDLTFQFKLSPGANSGVKYFVTLNEQTSGSAIGLEYQVLDDKEHPDAKMGKNGNRTLASLYDLITSKKNARAVKPIGEWNTGRIVVYPDNRVEHYLNGELMVSYVRGSKEYLDLVAGSKYKDWKNFGQASQGHILLQDHGDNVSFRSIKIKELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMG8</accession>
    <name>D7VMG8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
            <ecNumber evidence="2">3.5.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pbp</name>
        <name evidence="2" type="ORF">HMPREF0766_12165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.6" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001524.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12165"/>
    <dbReference type="EnsemblBacteria" id="EFK58173">
        <property type="protein sequence ID" value="EFK58173"/>
        <property type="gene ID" value="HMPREF0766_12165"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_15_1_10"/>
    <dbReference type="OrthoDB" id="537440at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="377" mass="42537" checksum="BBB0ABC4E9ACAF45" modified="2010-10-05" version="1">MSDIQKIIFSLLFIFSSTGIHAQHSRTAKSIQEIAEKYQAVGVAAVVVKDSKIVFTNNYGYQDQDMRQLLNDSTLFRIASISKSFSATSVMQLIEEGRLSLKDDCSQLIGFPVRNPKFPEQVITVEMLLSHTSGINDKNGYFDLDVINPQKNKNWSDSYNDYAPGQGYQYCNLNFNMVGAIIEKVTGQRFDQYVAEHVLHPLQLYGGYCVDSLDRSRFATLYTYENGSFVAQRAAYNPRSEEIRNYTLGHSTPVFSPTGGMKISAVDLARYMIMHMNYGRGNGKKIISKKSAIAMQTKRSDNENYGLALWSTDKLIPHVNLTGHTGSAYGLYSTMFFDPKHKYGFVVITNGCRLSETSGYNRMLQEIVNLLYQDCIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VML7</accession>
    <name>D7VML7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase, M28 family</fullName>
            <ecNumber evidence="2">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992675.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12237"/>
    <dbReference type="EnsemblBacteria" id="EFK57164">
        <property type="protein sequence ID" value="EFK57164"/>
        <property type="gene ID" value="HMPREF0766_12237"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019932_0_0_10"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M28" evidence="1">
        <location>
            <begin position="102"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="319" mass="35686" checksum="375A1C8E02C0BBEB" modified="2010-10-05" version="1">MLKRHLTLTTVFIFFLLQLGVKTGYAQEIDQSILKKHIYFLASDKMKGRGTGSKEVKKAADYIEKQFRKYGLTPKGEKGYRQTFTAKVRRVVVPDSIRKADNIIGFIDNGAPYTVVVGAHYDHLGTGHQGSSKDSLGVGKIHNGADDNASGTAALLEMARHYSTNNIKENYNLLFIAFGAEELGLVGSRYFTEHPTLPLDQITAMLNMDMIGRYNPQQGVAVIGYGTSKKWPEIFEGIKPAIKYYTGHDGNGGSDQTSFYKKDIPVLFFHTGGHPDYHMPTDDADKIDYLSLKGIIELELMVIDNIMKQQQKLDFQFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN91</accession>
    <name>D7VN91_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57388">
        <property type="protein sequence ID" value="EFK57388"/>
        <property type="gene ID" value="HMPREF0766_12461"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3084850_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="52" mass="5849" checksum="ACF00BAD64F312AD" modified="2010-10-05" version="1">MSAFVVFSGFERVIYQDSYPPAGGLEFDPAPRSKIIASTFFILLILDTPIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNB3</accession>
    <name>D7VNB3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993039.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12483"/>
    <dbReference type="EnsemblBacteria" id="EFK57410">
        <property type="protein sequence ID" value="EFK57410"/>
        <property type="gene ID" value="HMPREF0766_12483"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199837_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025842">
        <property type="entry name" value="Bacteroid_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026437">
        <property type="entry name" value="CxxCx5CxxC_targ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14406">
        <property type="entry name" value="Bacteroid_pep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04139">
        <property type="entry name" value="CxxCx5CxxC_targ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="74" mass="8303" checksum="753C7C62AEE26610" modified="2010-10-05" version="1">MKKLNGMKSFSSLENKKLESENLEGVSGGRAQERFSEVTSNFLNADGARDYDMYVGGRFVGRGWDTSNCEISHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNF5</accession>
    <name>D7VNF5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase, M23 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_12525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993093.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12525"/>
    <dbReference type="EnsemblBacteria" id="EFK57452">
        <property type="protein sequence ID" value="EFK57452"/>
        <property type="gene ID" value="HMPREF0766_12525"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029425_4_2_10"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107151" evidence="3">
        <location>
            <begin position="23"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="4">
        <location>
            <begin position="332"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="426" mass="47938" checksum="6392772FA79A45DA" modified="2010-10-05" version="1">MGFKKVLLSILALFFVVTASKAQSSALLQKQREQLTKEIAELQKVLQNTTKERKLSQQEVNALSKQLNLREEKISTINAEVRLIDNQISSNNKAVDALKAELEKLRKDYEKMIMFAFRNKNAYSKMMFIFASKDFNQAYRRVKYLQQFNDSRKIKADEIEATQNKIKQKIAQLQADKNKKNVLLKDQQNERSVIAKDKAEHSKVLNELASQERNVKSQLSKKQQQERKLAAQIKAAIAREIAEERRRAEAERKRLAEAEARKTGKTVAEVEKNTKRKSDGDVLKSTPEAARLSADFKSNRGRLPWPVGQGNIIRKFGMGSYGRNVTVYNPDIVIRTGENATIKAVFPGTVVQAFTSAGSGNVIINHGEYFTVYSDMKGLSVSKGQKVSAGQAIGTAGEDTEEGISLVKFSIFQGMTELNPESWLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNP9</accession>
    <name>D7VNP9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Haem_bd domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993219.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12619"/>
    <dbReference type="EnsemblBacteria" id="EFK57546">
        <property type="protein sequence ID" value="EFK57546"/>
        <property type="gene ID" value="HMPREF0766_12619"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120447_1_0_10"/>
    <dbReference type="OrthoDB" id="1935300at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025992">
        <property type="entry name" value="Haem-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14376">
        <property type="entry name" value="Haem_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01235">
        <property type="entry name" value="Haem_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Haem_bd" evidence="1">
        <location>
            <begin position="19"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="157" mass="18106" checksum="A58CE5B18F1D4D96" modified="2010-10-05" version="1">MKKNGKRTKAYKVILTVLLSVFVLMQFITPQRNLSPVPAGQVFVDSFKVDAKVNAILSVSCYDCHSNNTQYPWYTNVQPLGWFMADHITEGKEKLNFDDLPNYSPRRINSKFSQIIEQIEKGKMPLSSYTWMHGGARLSMEDKKLLVEYFNSLMDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNQ6</accession>
    <name>D7VNQ6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helicase C-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12626</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993227.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12626"/>
    <dbReference type="EnsemblBacteria" id="EFK57553">
        <property type="protein sequence ID" value="EFK57553"/>
        <property type="gene ID" value="HMPREF0766_12626"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0827">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4646">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000181_9_1_10"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="1355"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1772"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1555"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1772"/>
            <end position="1787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1810" mass="205895" checksum="60F4E7D8B0B53160" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNV8</accession>
    <name>D7VNV8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12678"/>
    <dbReference type="EnsemblBacteria" id="EFK57605">
        <property type="protein sequence ID" value="EFK57605"/>
        <property type="gene ID" value="HMPREF0766_12678"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030I5R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1439648_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="191" mass="22330" checksum="AA97F15374868A03" modified="2010-10-05" version="1">MLFNKLLMKRKIKDYSIQFIKEIIPVIAGILIALFIDNWNSERKDKAYINQIFSTIRSELVESKEDIKAIIPKQRSLIDSLDFYANNKDVAVLDIVMRSKGIYIPKVKINAWKSVSNTKIDLIDYKKIATLSNIEELKQTLNDKSDFLMGFLYSNINQTDKNTKQTFKMIIMDIIQTEKTIQDHIEVFEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNZ2</accession>
    <name>D7VNZ2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_12712</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12712"/>
    <dbReference type="EnsemblBacteria" id="EFK57639">
        <property type="protein sequence ID" value="EFK57639"/>
        <property type="gene ID" value="HMPREF0766_12712"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_0_3_10"/>
    <dbReference type="OrthoDB" id="384945at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="108"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="331"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="641" mass="73063" checksum="195D95CFE96D37B8" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP00</accession>
    <name>D7VP00_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3347 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993391.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12720"/>
    <dbReference type="EnsemblBacteria" id="EFK57647">
        <property type="protein sequence ID" value="EFK57647"/>
        <property type="gene ID" value="HMPREF0766_12720"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101306_0_0_10"/>
    <dbReference type="OrthoDB" id="1905459at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021782">
        <property type="entry name" value="DUF3347"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11827">
        <property type="entry name" value="DUF3347"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107476" description="DUF3347 domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3347" evidence="2">
        <location>
            <begin position="56"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="179" mass="19716" checksum="80A2A5FEB659FD29" modified="2010-10-05" version="1">MKTGIFSGCIIWIAALLLMGCNSTTKTSDTSITQQEKMTEVKQNVVGIKDDALNTVYQQYLLVSDALINSDMAAAKEAAMALELAAKALENSDQFVKLASTITAVSDIEKQRAVFSDLSNEMMSRIKTVGLKEGEVYLDYCPMALDDQGAVWLSNEKSIRNPYYGEKMMECGEVKETLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP22</accession>
    <name>D7VP22_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993429.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12742"/>
    <dbReference type="EnsemblBacteria" id="EFK57669">
        <property type="protein sequence ID" value="EFK57669"/>
        <property type="gene ID" value="HMPREF0766_12742"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042010_0_0_10"/>
    <dbReference type="OrthoDB" id="397741at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M14" evidence="1">
        <location>
            <begin position="59"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="487" mass="55388" checksum="CCF8770DFC44183F" modified="2010-10-05" version="1">MNKLLIICLLMLIGKDSFSQSLVLSKTQLDKAHMAYKESALKHRRFKHADVEQLILRHQQQHALDVQQIGSSVEQRSIYELRYGTGKKVVMLWSQMHGDEPTATMALFDLFNFLEGKEDDFEGVRTLLQEHLSIHFIPMLNPDGAERYTRRNAQKIDLNRDARNTATPEGKLLRARAESLKPQYGFNLHDQNIYYNVPGTQTPVTISLLAPAYNMERDINEVRGNAMKIIVGMEKLLQNYIPGAVAKYDDEHSPRAFGDNFQKWGASTVLIESGAFKGDPEKQEIRKLNFAIILNALVQIAQGSYQQYDIKDYERIPFNASQLHDVVLRNVSTVSGGLPLQVDIAIRRDEITSGNDYYSKGYIEDLGDLKEFYGYDDLDATGLTLSYGQIYPTAFRHYSELTADVIFGLLKQGYSTVIVREQDQQKALRLPVRIVQQPTEQRHVTGLSPGQEATFFLKKDNELKYAIVNGYLIDLSRNLPDAFNGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP28</accession>
    <name>D7VP28_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tat pathway signal sequence domain protein</fullName>
            <ecNumber evidence="4">3.5.1.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ansB</name>
        <name evidence="4" type="ORF">HMPREF0766_12748</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.26" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993439.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12748"/>
    <dbReference type="MEROPS" id="T02.007"/>
    <dbReference type="EnsemblBacteria" id="EFK57675">
        <property type="protein sequence ID" value="EFK57675"/>
        <property type="gene ID" value="HMPREF0766_12748"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021603_0_1_10"/>
    <dbReference type="OrthoDB" id="890789at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003948">
        <property type="term" value="F:N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="PTHR10188"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="227"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="250"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="198"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="340" mass="36629" checksum="596D8A030BA6E41B" modified="2010-10-05" version="1">MHSRRKFIKQGIVGAAALGSISTLSGFAEDKILKPGKPIVISTWDFGIAANQAAWEVLSKKGKAVDAVEQGVRVPEADLKNMTVGKGGYPDRDGNVTLDACIMDSEGNCGSVAALEHIAHPISVARLVMEKTPHVMLVGEGALQFALEQGFEKENLLTPEGEKAWKEWLKEKKYKPVMNIENKGFAAERLPGNQYNHDTIGMLALDSDGNLAGACTTSGMAFKMHGRVGDSPIIGAGLYVDNEIGGATSTGVGEEVIRTVGSFLVVELMRQGYSPEAACKEAVERIIKKKPQTAKEIQVGFLALNKKGEYGSYALQNGFSYAVCTEEKQDLLIKGKHIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP82</accession>
    <name>D7VP82_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_12802</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993529.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12802"/>
    <dbReference type="EnsemblBacteria" id="EFK57729">
        <property type="protein sequence ID" value="EFK57729"/>
        <property type="gene ID" value="HMPREF0766_12802"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031275_0_2_10"/>
    <dbReference type="OrthoDB" id="944044at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="353" mass="39423" checksum="2D45588978F471EE" modified="2010-10-05" version="1">MRKFISLPFYIKLACILISIVILGYLARIGDTIIVPLILGILFAMLLTPMSTLLEKKLRFPRTLAGIVCIVLFFGGLATGLYLLASQLSMLQEDWPAFKHQILDGVEVVQDWVNHQFGIQYNEQMNLLNKTASKSVDSGTLILGTALMSLSSIAIFLVFTFLYTFFILIYRGHIVRFLLYLNAKEDHPVVLEIVAEVQYVVKRYLIGLLLQMLIVTTLVYIALAIIGVKYSLLLAIITGVFNVLPYIGIFSSMFIVALITFATSTFSHVLFVFVAMSIIHMIDSNVIVPKVVGSKVKINSLFAMMAIVCGELIWGISGMFLAIPLLAIVKIVMDRVDELKPWGFLLGEEKVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPJ9</accession>
    <name>D7VPJ9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Triacylglycerol lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993771.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12919"/>
    <dbReference type="EnsemblBacteria" id="EFK57846">
        <property type="protein sequence ID" value="EFK57846"/>
        <property type="gene ID" value="HMPREF0766_12919"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044342_0_0_10"/>
    <dbReference type="OrthoDB" id="630413at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipase_3" evidence="1">
        <location>
            <begin position="77"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="354" mass="40911" checksum="ABAB0D5C203C8264" modified="2010-10-05" version="1">MKYPILLVVFGLFTSFTYAQSLKPGFEKEEYRTMLTLMSQVKEHPVYQDFTLRYTSPVMGLENRWWLWTSDEHKQAVIGIRGTVSSSESWLANFYAAMIPAKGQLQLDDSRIFEYNFSDDPKAAVHVGWTFSTGFLSADILPHLDSCYKAGIKDIYITGHSQGGAISYLLTSHLRHLQQQGQLPADIQLKTYSSAAPKVGNLYYAYQYEADTQIGWAFNVVNTMDWVPETPFSVQKLDDFNEINPFPQLEKAIQKQSFGKKIVIKHYLNRIKKPTEKSQKNIEKLLGHKVFTFLKKKYPHLVEPKYFPSSNYMRAGQHIVLKPDSSYTTSFPDDIKQPFMHHSFKSYFYLLDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPL3</accession>
    <name>D7VPL3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl hydrolase family 3 N-terminal domain protein</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bglX</name>
        <name evidence="5" type="ORF">HMPREF0766_12933</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12933"/>
    <dbReference type="EnsemblBacteria" id="EFK57860">
        <property type="protein sequence ID" value="EFK57860"/>
        <property type="gene ID" value="HMPREF0766_12933"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_5_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="4">
        <location>
            <begin position="666"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="747" mass="81942" checksum="7A955D0414D063B7" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPN7</accession>
    <name>D7VPN7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993818.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12957"/>
    <dbReference type="EnsemblBacteria" id="EFK57884">
        <property type="protein sequence ID" value="EFK57884"/>
        <property type="gene ID" value="HMPREF0766_12957"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101141_4_0_10"/>
    <dbReference type="OrthoDB" id="1989068at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="147" mass="17114" checksum="B920733263DC59E0" modified="2010-10-05" version="1">MENTFYEGQVIWAQIDANRHMRHSAYADICAQARSNMLKKIGLSLDQFASQGIGPILFREELIYHREVRLDEYVSVKIVLTKFNLANARFSFRHEVYKEDGVKAATVNVDGAWLDIKARKLVNIPEDWYVFMQHVPKADDYEEFDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ42</accession>
    <name>D7VQ42_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994034.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13096"/>
    <dbReference type="EnsemblBacteria" id="EFK55893">
        <property type="protein sequence ID" value="EFK55893"/>
        <property type="gene ID" value="HMPREF0766_13096"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032WGR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2700891_0_0_10"/>
    <dbReference type="OrthoDB" id="1959640at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021529">
        <property type="entry name" value="DUF2798"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11391">
        <property type="entry name" value="DUF2798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="74" mass="8718" checksum="D09C8333657F47FB" modified="2010-10-05" version="1">MKQKYFKYVNTLFVVIPMTLIMAIVGLMRTYGFGEDWFFKFLKSWTTMLPVAYMAAFIIIPNARKIAEKLLIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ63</accession>
    <name>D7VQ63_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">metI</name>
        <name evidence="6" type="ORF">HMPREF0766_13117</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994064.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13117"/>
    <dbReference type="EnsemblBacteria" id="EFK55914">
        <property type="protein sequence ID" value="EFK55914"/>
        <property type="gene ID" value="HMPREF0766_13117"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077375_0_1_10"/>
    <dbReference type="OrthoDB" id="1464674at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="13"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK55914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="217" mass="23337" checksum="36E00DBBA74CD24C" modified="2010-10-05" version="1">MSDTIVKLLLEGTWQTLVMTFASGFFGFLLGLPTGILLFVTRKGQIMQNKAVHQITSVIVNIFRSIPFIILIVWMIPFTRELVGTSIGVSAALVPLSIGAAPFVARLVENSLLEIPAGLIEAARAMGATHKQIILKVLLPESLPSMVNNATITLITLVGYSAMGGAVGAGGLGQIGYQYGYIGYDAFIMNAVLILLILIVFLLQFTGDFIAKKTNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ74</accession>
    <name>D7VQ74_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_13128</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13128"/>
    <dbReference type="EnsemblBacteria" id="EFK55925">
        <property type="protein sequence ID" value="EFK55925"/>
        <property type="gene ID" value="HMPREF0766_13128"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="250"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="578"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="34"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK55925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1212" mass="135319" checksum="E6C72EE20CCD037D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ82</accession>
    <name>D7VQ82_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase, family 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994089.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13136"/>
    <dbReference type="EnsemblBacteria" id="EFK55933">
        <property type="protein sequence ID" value="EFK55933"/>
        <property type="gene ID" value="HMPREF0766_13136"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010399_3_1_10"/>
    <dbReference type="OrthoDB" id="318658at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="11"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="221"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK55933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="597" mass="69537" checksum="81AC2CC15641E089" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQC1</accession>
    <name>D7VQC1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphomethylpyrimidine synthase</fullName>
            <ecNumber evidence="10">4.1.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Hydroxymethylpyrimidine phosphate synthase</fullName>
            <shortName evidence="10">HMP-P synthase</shortName>
            <shortName evidence="10">HMP-phosphate synthase</shortName>
            <shortName evidence="10">HMPP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thiamine biosynthesis protein ThiC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">thiC</name>
        <name evidence="12" type="ORF">HMPREF0766_13175</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:24840"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.99.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ThiC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.17" evidence="10"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994178.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13175"/>
    <dbReference type="EnsemblBacteria" id="EFK55972">
        <property type="protein sequence ID" value="EFK55972"/>
        <property type="gene ID" value="HMPREF0766_13175"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0422">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013181_2_1_10"/>
    <dbReference type="OrthoDB" id="505395at2"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00089">
        <property type="entry name" value="ThiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037509">
        <property type="entry name" value="ThiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025747">
        <property type="entry name" value="ThiC-associated_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038521">
        <property type="entry name" value="ThiC/Bza_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002817">
        <property type="entry name" value="ThiC/BzaA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30557">
        <property type="entry name" value="PTHR30557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13667">
        <property type="entry name" value="ThiC-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01964">
        <property type="entry name" value="ThiC_Rad_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00407">
        <property type="entry name" value="phosphomethylpyrimidine_syntha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00190">
        <property type="entry name" value="thiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ThiC-associated" evidence="11">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="337"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="378"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="565"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="568"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="573"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK55972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="605" mass="67950" checksum="5B9F1C3D0E118481" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQI1</accession>
    <name>D7VQI1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994305.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13235"/>
    <dbReference type="EnsemblBacteria" id="EFK56032">
        <property type="protein sequence ID" value="EFK56032"/>
        <property type="gene ID" value="HMPREF0766_13235"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50337SM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_882514_0_0_10"/>
    <dbReference type="OrthoDB" id="1491935at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="313" mass="37542" checksum="297CE4469BDDF5B3" modified="2010-10-05" version="1">MAQNAIRRFTLLGLFLIICNSYLFGQVKYFIIEPENEDQKYDLHTYKLATKTLYGIDNSVELYNIVYINNIYDKHEDSEKNLILFSVLPNLEGGSDNWKEISLDTIQSKLLPIGKLKNLFQRNTMSIFSEKYGEKTKYFNEYKIVIKKEGKYFTPYNCLLQFYAIRNRSEIFSNVYGTINTKLNPVTVSDFELIFESTYPKTYFPIYTLPNERHTATLDRLRDRREYLSKKWKLKDGSIAFQFWTYTDWHEPDFYYEYERGIDRFVYIPDKGIVGGSFDFYFYYHRQKLGMTTLDFKNNIRKEKVMLAEEYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQQ3</accession>
    <name>D7VQQ3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter, small conductance mechanosensitive ion channel MscS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mscS</name>
        <name evidence="8" type="ORF">HMPREF0766_13307</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994427.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13307"/>
    <dbReference type="EnsemblBacteria" id="EFK56104">
        <property type="protein sequence ID" value="EFK56104"/>
        <property type="gene ID" value="HMPREF0766_13307"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032048_1_0_10"/>
    <dbReference type="OrthoDB" id="1903165at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK56104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="541" mass="61541" checksum="EA656788CE2F92FE" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQQ6</accession>
    <name>D7VQQ6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Penicillin-binding protein, transpeptidase domain protein</fullName>
            <ecNumber evidence="2">3.5.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bla</name>
        <name evidence="2" type="ORF">HMPREF0766_13310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.6" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994433.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13310"/>
    <dbReference type="EnsemblBacteria" id="EFK56107">
        <property type="protein sequence ID" value="EFK56107"/>
        <property type="gene ID" value="HMPREF0766_13310"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2602">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035412_3_0_10"/>
    <dbReference type="OrthoDB" id="1688418at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transpeptidase" evidence="1">
        <location>
            <begin position="72"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="324" mass="37561" checksum="1FB81C087E4D5F3E" modified="2010-10-05" version="1">MLLFTSILYKQCIFIIMKNSLIFFVYNLFCILSSQSHTASAQQTGEVKISFRNDSVTVREEFNRYFENKHAQGDILILDLQNNKWFASDAKSVYVPALPASTFKIINLLIALETKVIADENQVVKWIGQTDTVKYGYRPDIYRDMTVKEAFEKSAGWVFVELSKKIGKKNYQHYLSLAGYGNADLSEADPDFWNFGNFGISPYNQVDFLRKLYLEQLPFKKRHMQTVKRVMLSNEYPDAEVHAKTGWTRIDGLNIGWWVGYIEKQKNTYLFATRLFQDCDRKDPGFGPGRKEITRAVLEELRFLNFSSPSAKTSTLIIQSHLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQR7</accession>
    <name>D7VQR7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994446.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13321"/>
    <dbReference type="EnsemblBacteria" id="EFK56118">
        <property type="protein sequence ID" value="EFK56118"/>
        <property type="gene ID" value="HMPREF0766_13321"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008878_4_0_10"/>
    <dbReference type="OrthoDB" id="365211at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="1">
        <location>
            <begin position="96"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="2">
        <location>
            <begin position="426"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="562" mass="63241" checksum="357FF3AD20D99DEA" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQV3</accession>
    <name>D7VQV3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13357"/>
    <dbReference type="EnsemblBacteria" id="EFK56154">
        <property type="protein sequence ID" value="EFK56154"/>
        <property type="gene ID" value="HMPREF0766_13357"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033HVA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157250_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="119" mass="14172" checksum="17CF205C8A3B352F" modified="2010-10-05" version="1">MSEHIFFYTGLSLFTIHEMDAIHCKEWRIFPGLSFLDDRWGFRIFMFAHIPIFLFINRQLHDVPTSETFMKRFNVFLMVHMGFHLLYLKHKRNEFTDGISWFYIAGAGICGIVDLFGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQW8</accession>
    <name>D7VQW8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_13372</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994509.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13372"/>
    <dbReference type="EnsemblBacteria" id="EFK56169">
        <property type="protein sequence ID" value="EFK56169"/>
        <property type="gene ID" value="HMPREF0766_13372"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_10"/>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="349" mass="39137" checksum="658DE1A57A20127D" modified="2010-10-05" version="1">MHVFLNFGKIQYVMKRVTIKDLSKYLSLSTSTISRALVNDKNIHPETKQKVLEMAEKMGYKPNPTALNLKYGQSKSIGFVVPEMTTPFSAKVLKGIQSILYPLGYRIIIMQSDENPEIERKNLLMLEEFNVDGIIINLCHETYNMDLYQQIMGRGTALVFFDRIPAKSLEASKVMVNDHIKASLMVEHLIATGRRRIVHIKGPSSIRNATERALGYERILTKHGIFDPELLIKTDGATFEHGRNVAQQLLSKNIKFDSIFAFTDTLAIGAMNYLLEQGINIPQQVSIASFSGTELATIVHPQLSSVEQPLTKMGETAAHMMLDKIKNNTGECQTVVMDAELIYRASTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR02</accession>
    <name>D7VR02_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994554.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13406"/>
    <dbReference type="EnsemblBacteria" id="EFK56203">
        <property type="protein sequence ID" value="EFK56203"/>
        <property type="gene ID" value="HMPREF0766_13406"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_0_10"/>
    <dbReference type="OrthoDB" id="1024978at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="468" mass="52826" checksum="21AA66039294B665" modified="2010-10-05" version="1">MKSFKYEIFTSFIEKNISEGIYMPGHKLPSVREVKDKYQISISTVQSGYEYLMIRGLVISIPKSGYFVATATEKKQEKISSRRKPVVRDPLFKNNLLLTTSLRSGRQLSEFNVAAPGDLLVPQKLLLRTMQQVIREEGASLLRYYPANGSSDLRKTISGYAAGYQTVLPPEELLITDGALQSLYIALSSVCTAGDVIAVESPCVFSVLEIIRVLHLRVIEIPADTQSGFDVDFFRKACEKNTIKAVLLTPNFHNPTGILLSDEKKKDLLRIIQHEGIALIENDIYGDLSFTNKRPLPVKAFDESGLVMTYSSYSKTLAPGIRLGWLSAGRFMERAEQIRFSLGSSVSPVYQETVDRLLKTNSYDRHLRHFRKQLAKNAHLTVRLLSENFPKDTTLLTPSGGYNLWVRMPDQINMEGFYRQCNKIGVRFTPGYTFSFSGIFSNYFRIVFSDNYTTQRIEALRLAGQLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR10</accession>
    <name>D7VR10_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994569.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13414"/>
    <dbReference type="EnsemblBacteria" id="EFK56211">
        <property type="protein sequence ID" value="EFK56211"/>
        <property type="gene ID" value="HMPREF0766_13414"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_4_0_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014327">
        <property type="entry name" value="RNA_pol_sigma70_bacteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02985">
        <property type="entry name" value="Sig70_bacteroi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="28"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="124"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="175" mass="20719" checksum="6C8E53386C64EB45" modified="2010-10-05" version="1">MADSQLIDFRQKEEAFVMRKLHDRQWQKLLHFCYNIVGEEAEAQDIVQDSFMAIWKIRDRWETIESLDNYLFMVCRNNALALLKKQKEIRRLAEDIAIHLQNRIQHSALEHIYASETNQHIQGQIQTFPAKMKEVFLLSREEELSQKEIAAKLAISENTVKKQINNVLKVLKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRI8</accession>
    <name>D7VRI8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aspartokinase</fullName>
            <ecNumber evidence="6">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lysC2</name>
        <name evidence="9" type="ORF">HMPREF0766_13592</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994788.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13592"/>
    <dbReference type="EnsemblBacteria" id="EFK56389">
        <property type="protein sequence ID" value="EFK56389"/>
        <property type="gene ID" value="HMPREF0766_13592"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0527">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_6_0_10"/>
    <dbReference type="OrthoDB" id="1067792at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042199">
        <property type="entry name" value="AsparK_Bifunc_asparK/hSer_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="2"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="5"/>
            <end position="8"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK56389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="420" mass="47940" checksum="87920B7A56726F32" modified="2010-10-05" version="1">MQVFKFGGASVKDAESIKNVASIILKYKEEPLLVVVSAIGKTTNALEELTKTFFQQSGDAFELLNEVKKSHFSILDQLFADHSHPIFDEIANAFVEIEWILEEEPLDTYDYLYDQIVSLGELLSSRIISAYAAHVGVRSRWTDARDYIFTDNTYREGKVDWEKTEDKIREELPILLDDYVLITQGFIGSTSENFTTTLGREGSDYSAAIFAACLNAESVTIWKDVPGVLNADPKWFEKTQLIQELSYTDAIELTYYGATVIHPKTIKPLQNKKIALHVRSFIDSTQPGTTIKSTNQTLPVPSFIFKVDQVFINISPRDFSFIVEDNLSHIFNLFHLHRIKINMMHNSAIQFSVAVDNTGDNVKTLLEELEKRYKVAVESGLELITIRYYNQETIDRVLLNKEIIKELKDSYTCQMLVKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRM2</accession>
    <name>D7VRM2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HMGL-like protein</fullName>
            <ecNumber evidence="4">4.1.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hmgcl</name>
        <name evidence="4" type="ORF">HMPREF0766_13626</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994860.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13626"/>
    <dbReference type="EnsemblBacteria" id="EFK56423">
        <property type="protein sequence ID" value="EFK56423"/>
        <property type="gene ID" value="HMPREF0766_13626"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022138_3_2_10"/>
    <dbReference type="OrthoDB" id="1111394at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="PTHR42738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="282" mass="31545" checksum="633B650123A33C8B" modified="2010-10-05" version="1">MPDLNQNITLVECPRDAIQGLHGQISTEKKVAYINFLIRTGLFECIDFGSFVSPVAVPQMADTEAVVRQLDLINDTRLLAIVVNEKGVERATAFEQIHYLGYPFSISEEFQRRNTNANLQQSFERLKYIVERTKAGGKEPVVYISMAFGNPYKEIWSEQLVIDWLGNIAELGVTRFSLADTTGEASVEQIDSLFHKVYELFTELHIGAHFHSTKLNSMAKIKAAFDSGCKTFDGAMLGYGGCPFAKDDLVGNIAMEDLLLFFGRGNAPQIEELKQQFNTLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRU8</accession>
    <name>D7VRU8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M16 inactive domain protein</fullName>
            <ecNumber evidence="3">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995056.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13702"/>
    <dbReference type="EnsemblBacteria" id="EFK56499">
        <property type="protein sequence ID" value="EFK56499"/>
        <property type="gene ID" value="HMPREF0766_13702"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_1_1_10"/>
    <dbReference type="OrthoDB" id="1188251at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="1">
        <location>
            <begin position="14"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="2">
        <location>
            <begin position="171"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="417" mass="47307" checksum="72505504EAF94C2D" modified="2010-10-05" version="1">MIKFQKFVLDNGLRVLVHEDHNTAMACVNILYDVGARDESPDQTGFAHLFEHLMFGGSVNIPNYDTPLQRVGGENNAFTSNDITNYYITLPAVNIETAFWLESDRMLSLAFSEQSLDVQKQVVVEEFKQRYLNQPYGDAWLKLRPLAYQVHPYKWATIGKEISHIEEARMEDVKAFFTKHYNPLNAIMVVSGDVTLEQVKQLTNKWFGDIPSGEKYNRNLPSEPVQTEARRLEVEADVPVDAVHMVFHGPNRLSPEYQAMDLISDILSRGSSSRLFRKLVKEKKIFSEINAYVTGSIDDNLFVIEGKPSEGISTAEAEAAIWEQLNFLKNTEVSAEELEKVKNKIESTLVFAELSILDKAMNLAYYELLGDGNLYNVEIGKYLTVTAAEVRAQANQIFREENSSTLIYHAKPEPIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS05</accession>
    <name>D7VS05_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995198.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13759"/>
    <dbReference type="EnsemblBacteria" id="EFK56556">
        <property type="protein sequence ID" value="EFK56556"/>
        <property type="gene ID" value="HMPREF0766_13759"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2131949_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="113" mass="13133" checksum="8FDB751089514D1A" modified="2010-10-05" version="1">MEIVSIFISQWADKCWQKETKGGRRTTGLWSQMTPVRLLADDPVVGRWNVVVDPLTEQYRRWSPYNYTINNPIRFVDPDGMAVEEIEGGFKYTKEDAVAMVSQLKNEYLDQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS75</accession>
    <name>D7VS75_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, ATP-binding protein</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_13829</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995370.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13829"/>
    <dbReference type="EnsemblBacteria" id="EFK56626">
        <property type="protein sequence ID" value="EFK56626"/>
        <property type="gene ID" value="HMPREF0766_13829"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_10"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="338"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="371"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK56626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="528" mass="60001" checksum="97CF8B21060EC025" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS79</accession>
    <name>D7VS79_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13833</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995389.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13833"/>
    <dbReference type="EnsemblBacteria" id="EFK56630">
        <property type="protein sequence ID" value="EFK56630"/>
        <property type="gene ID" value="HMPREF0766_13833"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005632_1_0_10"/>
    <dbReference type="OrthoDB" id="520387at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011429">
        <property type="entry name" value="Cyt_c_Planctomycete-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011444">
        <property type="entry name" value="DUF1549"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022655">
        <property type="entry name" value="DUF1553"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07635">
        <property type="entry name" value="PSCyt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07583">
        <property type="entry name" value="PSCyt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07587">
        <property type="entry name" value="PSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSCyt1" evidence="3">
        <location>
            <begin position="43"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="PSCyt2" evidence="1">
        <location>
            <begin position="158"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="PSD1" evidence="2">
        <location>
            <begin position="607"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="919" mass="104772" checksum="B4F30AF7D3D84B63" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSA0</accession>
    <name>D7VSA0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyl hydrolase, family 43</fullName>
            <ecNumber evidence="9">3.2.1.37</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">xynB</name>
        <name evidence="9" type="ORF">HMPREF0766_13854</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="9"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995435.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13854"/>
    <dbReference type="EnsemblBacteria" id="EFK56651">
        <property type="protein sequence ID" value="EFK56651"/>
        <property type="gene ID" value="HMPREF0766_13854"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016508_2_1_10"/>
    <dbReference type="OrthoDB" id="442641at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107317" evidence="7">
        <location>
            <begin position="23"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="GH43_C2" evidence="8">
        <location>
            <begin position="354"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK56651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="548" mass="62209" checksum="748BD018B37E74DC" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSJ4</accession>
    <name>D7VSJ4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Xaa-His dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pepD</name>
        <name evidence="1" type="ORF">HMPREF0766_13948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995601.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13948"/>
    <dbReference type="EnsemblBacteria" id="EFK56745">
        <property type="protein sequence ID" value="EFK56745"/>
        <property type="gene ID" value="HMPREF0766_13948"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028526_0_0_10"/>
    <dbReference type="OrthoDB" id="1015417at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03890">
        <property type="entry name" value="M20_pepD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001160">
        <property type="entry name" value="Peptidase_M20C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43501">
        <property type="entry name" value="PTHR43501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016599">
        <property type="entry name" value="Xaa-His_dipept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00934">
        <property type="entry name" value="XHISDIPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01893">
        <property type="entry name" value="aa-his-dipept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="487" mass="52676" checksum="AA385C422A3B9C2B" modified="2010-10-05" version="1">MNQEILQLQPQSIWKNFNALNAVPRASKKEERVIAFIQDFGKSLGLETITDKTGNVVIRKPATAGMEDRKGIVLQSHLDMVHQKNNDTVFDFDADGIRMLIDGDWVKADGTTLGADNGIGVATIMAILESKELAHPAIDALFTIDEETGMTGAFGLEGGVLQGEILLNLDTEDDTEIDIGCAGGVDVTATKSYSSEPVLNGYAGLTITVKGLNGGHSGMEIHKGLGNANKIMNRVLFGTHAGFGLRLSEIKGGGLRNAIPRESVAKVVLPQEQVQHFISAADIVIQAIKAEYKSVDAGLEIVIDQQEHTPVTILPLDVQEQLIKAVYAAHNGVYRMSADFADLVETSNNIANIEVKDGKITIKCLTRSSVESSKYDLANALKSTFELMGAEVGFSGDYPGWTPDANSQILQVLKDIYEKQYHEKPEVVACHAGLECGILGRNYPGMDMISFGPTILGAHSPAERVSISSVQKFWAFIQEILVNIPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSL6</accession>
    <name>D7VSL6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RND transporter, HAE1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">acrB</name>
        <name evidence="8" type="ORF">HMPREF0766_13970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995633.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13970"/>
    <dbReference type="EnsemblBacteria" id="EFK56767">
        <property type="protein sequence ID" value="EFK56767"/>
        <property type="gene ID" value="HMPREF0766_13970"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_1_10"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="874"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="897"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="927"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="973"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1004"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1042"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1483"/>
            <end position="1510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK56767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1521" mass="167806" checksum="E21208B46B511521" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VST2</accession>
    <name>D7VST2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">macB</name>
        <name evidence="5" type="ORF">HMPREF0766_14036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995783.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14036"/>
    <dbReference type="EnsemblBacteria" id="EFK56833">
        <property type="protein sequence ID" value="EFK56833"/>
        <property type="gene ID" value="HMPREF0766_14036"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_10"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="233" mass="25701" checksum="F7059FD3271089CC" modified="2010-10-05" version="1">MIHIKDLTKVFTTEEVQTKALNNINLTITEGEFVSIMGPSGCGKSTLLNIVGLLDHISAGSYQLLGEEIAKLSESGRSKVRKANIGFIFQNFNLIDELSVFDNIELPLIYNKVPAAERKSRIHEIAEKLNIAHRLQHYPQQLSGGQQQRVAVARALINNPKIILADEPTGNLDSTNGNEVMELLTRLHAGGATILMVTHSAQDAAFSQKIITMKDGEILSEKINQKTVDIFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSW4</accession>
    <name>D7VSW4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dihydrodipicolinate synthase</fullName>
            <ecNumber evidence="2">4.3.3.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995857.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14068"/>
    <dbReference type="EnsemblBacteria" id="EFK56865">
        <property type="protein sequence ID" value="EFK56865"/>
        <property type="gene ID" value="HMPREF0766_14068"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_7_1_10"/>
    <dbReference type="OrthoDB" id="1438588at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="297" mass="32758" checksum="7A361C72B3F09912" modified="2010-10-05" version="1">MNQNLFKGIVSYPITPFDQQEKVDLRLFKILVERLVVTGSHAIAPLGSTGVLPYLTDAEKESITLATVEQVAGRIPVLAGVSNLTTERTVHHARFAEKAGADAVMIIPMSYWKLTEDEIFRHYQTVADAINIPVMAYNNPATGGIDMSPSLLIRLLQIPNVTMIKESTGDVQRMHQLYQAFGKDVAFYNGSNPLALAAFTAGATGWCTAASNLIPDLTKALYEAVCQNNLPEAQRLYYQQAELLKFIVEKGLPRTIKAGLHLMGIDAGYLRNPLQPLSEKEIATLRTILFKTINKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSY5</accession>
    <name>D7VSY5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative chlorophyll synthesis pathway protein BchC</fullName>
            <ecNumber evidence="4">1.1.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gutB2</name>
        <name evidence="4" type="ORF">HMPREF0766_14089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995883.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14089"/>
    <dbReference type="EnsemblBacteria" id="EFK56886">
        <property type="protein sequence ID" value="EFK56886"/>
        <property type="gene ID" value="HMPREF0766_14089"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_10"/>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="10"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="352" mass="37488" checksum="E3DF500D0F7B2EBA" modified="2010-10-05" version="1">MSTMKAARWHAAKDIRVEETQIPVTGKQQVKIAVQYAGICGSDLHEYVHGPQLIPSEKPYPLNGHIGVTTLGHEFSGIVEEVGEGVNRVKKGDRVVVEPIFKNFDSPFIANGEYNLSEPLGFVGLTSNGGFAKYTVVEDYMVHKIPDSMSFEQGALVEPAAVAVYAVLQSGLRMGQTVLVSGAGPIGLLCVQAAIAAGAATVIVTDISEKRLEKAKDIGATTIINAADKDIPAQVRRITGIGVDVFLDAAGVQASFSTGIASLRNGGTAVLVALFGKPVEYSAYDQVVREITIKGIIAYRNIFPQVIAMIDSGRMPVEKLVTSKIGLDEIVPKGFEALVSNPSEVKILVEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSY6</accession>
    <name>D7VSY6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14090"/>
    <dbReference type="EnsemblBacteria" id="EFK56887">
        <property type="protein sequence ID" value="EFK56887"/>
        <property type="gene ID" value="HMPREF0766_14090"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3066347_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="53" mass="6413" checksum="54AB49C90739EE05" modified="2010-10-05" version="1">MRDNMECTILTIKIILLQLYKGGTKSRYRGTFWMLLMRIKVLMEFRNMKSLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT71</accession>
    <name>D7VT71_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996081.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14175"/>
    <dbReference type="EnsemblBacteria" id="EFK56972">
        <property type="protein sequence ID" value="EFK56972"/>
        <property type="gene ID" value="HMPREF0766_14175"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZSJK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1668292_0_0_10"/>
    <dbReference type="OrthoDB" id="1951208at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032774">
        <property type="entry name" value="WG_beta_rep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14903">
        <property type="entry name" value="WG_beta_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="158" mass="17847" checksum="A7FFA406510059F5" modified="2010-10-05" version="1">MDKYGKVIINAKYDMLSFFEHGTAIFQIDGKSGLIDEQDKQIIPANYGYIADRNATHFIAIEGELYNLYTIKDQKRLGGNIQFIATTEDPNIFLAQKGDKYGFLDQNGKVMIPFKYAYATGFSNGVAYVAMDADMEDLFLINTKDERVEEGSEVLIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT72</accession>
    <name>D7VT72_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996084.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56973">
        <property type="protein sequence ID" value="EFK56973"/>
        <property type="gene ID" value="HMPREF0766_14176"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_767045_0_0_10"/>
    <dbReference type="OrthoDB" id="2230019at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107656" evidence="1">
        <location>
            <begin position="19"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="361" mass="41725" checksum="47BBBE0AD19B3FFD" modified="2010-10-05" version="1">MKHLLLLFFISLYYPLSAQNSSELISEATELKSMKSYLAKITLKEWPYMIPFQQDKKWGYLDQRTMKITVPALANTLYLFKPEGYIGTFNDYKNDIFYTLTLDEEGKLRTHSEQVAELVMPPQQYGRSPNPNIKPIPSENGYTGFEYKIIAGDIIEITAYSDLYASYNVKEPKLIPLWIDGKVYAIAGKTTSDPHVTYFGIITSDGKPLPGFNFEHQKVIPIGGLKDTTSSWFLTQPIGGRDTKYSYMNHKGEYKLKDSLSSRMYNWVYQSSQEHYPYYMPVKTTVGYVLTEQRIIDTYELKCINTLPQGYKLEYLDYMNTKAYSKESPDITRQTTKVFVVVSLDDKSCYMDLEGKIYEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTB7</accession>
    <name>D7VTB7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996214.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14221"/>
    <dbReference type="EnsemblBacteria" id="EFK57018">
        <property type="protein sequence ID" value="EFK57018"/>
        <property type="gene ID" value="HMPREF0766_14221"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074803_0_0_10"/>
    <dbReference type="OrthoDB" id="1242748at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="39"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="328" mass="37708" checksum="D9956452E899726E" modified="2010-10-05" version="1">MINRKSFLKIGGLGITGLLLNPALASARISTDKASQRIRFGVITDLHYDLMHDSEKRAAAFIAAMKQEKPDFIIQLGDFCMPKPQNRPLMDIWNSFEGEKYHVLGNHDTDGGYTKEQTLAFWSAERPYYSFDKNGFHFIVLDGNEKSETTEIAGYPRTIAKKQLEWLRDDLQKTSLRTVIFCHQGLENTLGGLDNGMEVRYLLEQINEKAGFKKVILVLTGHHHMNYHNEINGIHYVQINSASYYWAGEDFKSQAFSEDFYKKHRILQYTLVYEEPIWAMIDINNKNKISIKGKKTSMTGTPLEQTGIDIYKDVYPISSEIDSRVLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTH9</accession>
    <name>D7VTH9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4268 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996381.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14283"/>
    <dbReference type="EnsemblBacteria" id="EFK57080">
        <property type="protein sequence ID" value="EFK57080"/>
        <property type="gene ID" value="HMPREF0766_14283"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031J2R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144168_0_0_10"/>
    <dbReference type="OrthoDB" id="1909185at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025364">
        <property type="entry name" value="DUF4268"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14088">
        <property type="entry name" value="DUF4268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4268" evidence="1">
        <location>
            <begin position="27"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="169" mass="20223" checksum="C054C7A7A1A48926" modified="2010-10-05" version="1">MFEFFNSFEQKLQGFTLYSREESKRIKETFWTKFGQFMSLQPNSEGAKINWINYRTGIKHLYFRMNADKRTAEIMIEISHPDTGIRLLMFEQFEQYKTLLHAVLGEEWNWEKDSYDADGKKISRIYAAVSGISIYNENDWPELISFFKPRIAALDEFWNDAQYGFDLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTP2</accession>
    <name>D7VTP2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001691.1">
        <property type="nucleotide sequence ID" value="NZ_GL379777.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14362"/>
    <dbReference type="EnsemblBacteria" id="EFK55801">
        <property type="protein sequence ID" value="EFK55801"/>
        <property type="gene ID" value="HMPREF0766_14362"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1721180_0_0_10"/>
    <dbReference type="OrthoDB" id="2197654at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="152" mass="17937" checksum="E71C1221048DEF93" modified="2010-10-05" version="1">MFLRIVINTLTALLIFPVTISYREWSNILSGNYQYYDTTYESAGEYISKTILHPMAYPLVPVLFLLFILMPFQFIKNYYKHKGMELPFLKKWLIFSLLLAICGILWGMVSNLWQTVWYHNLVYLLYIAGFSLFFTALLHFTADKVKEKPVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTQ4</accession>
    <name>D7VTQ4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14374"/>
    <dbReference type="EnsemblBacteria" id="EFK55813">
        <property type="protein sequence ID" value="EFK55813"/>
        <property type="gene ID" value="HMPREF0766_14374"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2384647_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="94" mass="11265" checksum="C8D7EA42708E960E" modified="2010-10-05" version="1">MEIISAFFNENDNKNASLTSIYPQPTPVFNRKRTTKVQLFTLNIKELFCKIIFPRETQKLQILCVKLKRFRKFTSPKPPFARFHFLFLDFISYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGI1</accession>
    <name>D7VGI1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_10100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0187 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002056.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10100"/>
    <dbReference type="EnsemblBacteria" id="EFK60156">
        <property type="protein sequence ID" value="EFK60156"/>
        <property type="gene ID" value="HMPREF0766_10100"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029790_4_1_10"/>
    <dbReference type="OrthoDB" id="1348684at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin/UPF0187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="UPF0187"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="PTHR33281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK60156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="294" mass="33855" checksum="3B37B404D6F0141A" modified="2010-10-05" version="1">MQVYNPKEWFKATFYLHKSDTVRKLLPYLLLAAAFSGGIAYLELEYLRLSEKSWIKNITIVHSLLGFALSLLLVFRTNTAYDRWWEARKQWGILTNISRTLAYKMNAFLPEDDHTNRSFFRKAIPLYAELTQSFLRSDYTTYMLDDKEHPELGNLDLKKHAPNQLAALIFKKVTNLYKSGILSGEQFIILNDELQSLTNICGACERIKNTPIPQSYSSFIKKFIVFYVFTLPVGYVFSIGYFVIAAVPFVFYVLASLELIAESIEDPFGIDSDDLPLEKLAANIKKHSHEILHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGK3</accession>
    <name>D7VGK3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_10122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996634.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10122"/>
    <dbReference type="EnsemblBacteria" id="EFK59205">
        <property type="protein sequence ID" value="EFK59205"/>
        <property type="gene ID" value="HMPREF0766_10122"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2911">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002997_1_1_10"/>
    <dbReference type="OrthoDB" id="165470at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007452">
        <property type="entry name" value="TamB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04357">
        <property type="entry name" value="TamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1452" mass="163627" checksum="A7576C10F05ECBC3" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGX0</accession>
    <name>D7VGX0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sua5/YciO/YrdC/YwlC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996960.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10239"/>
    <dbReference type="EnsemblBacteria" id="EFK59322">
        <property type="protein sequence ID" value="EFK59322"/>
        <property type="gene ID" value="HMPREF0766_10239"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_3_2_10"/>
    <dbReference type="OrthoDB" id="1913202at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="191" mass="21122" checksum="451EB47028E9B21C" modified="2010-10-05" version="1">MTPIDREDINKALETLKNGGLILYPTDTIWGIGCDATNPEAVDRIIQLKGRSKEKSMIVLLHNENQLAGYVNDIPEVAYQLIEYTEHPLTIVYSNAKNLAANAIAEDGSIGIRIVNHPFCTQLLQRFRKPIISTSANISGEPSAKTFGDIDQKIKDGVDYTVQFGQKDRGAGKASTIMKLDPSGKFEFIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH05</accession>
    <name>D7VH05_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997064.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10274"/>
    <dbReference type="EnsemblBacteria" id="EFK59357">
        <property type="protein sequence ID" value="EFK59357"/>
        <property type="gene ID" value="HMPREF0766_10274"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_2_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107097" evidence="1">
        <location>
            <begin position="25"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="116"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1105" mass="122940" checksum="3950060E6829C990" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH30</accession>
    <name>D7VH30_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purR2</name>
        <name evidence="5" type="ORF">HMPREF0766_10299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10299"/>
    <dbReference type="EnsemblBacteria" id="EFK59382">
        <property type="protein sequence ID" value="EFK59382"/>
        <property type="gene ID" value="HMPREF0766_10299"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="28"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="361" mass="40269" checksum="F48EEFE8FCA7B250" modified="2010-10-05" version="1">MANATACIKVFIFFYIYKKSLIKVEKKPTIYDIAKALNITTSTVSRALNNSTLISKETKETVWKFAKKINYRPNKLASSLSSGKTNIIGVVIPSAQIQFFSAVINSLEQTLQKEGYNILLYQTNESYKSEISGISTLLEAQVDGIIISPSLETYDFTHLDKAHEEGMPVILFDRVHDTLDLPSVSIDDEKAGYMATTHLIEKGYKRIGYISTDSTIQIFKARFEGYKRALKAHDHPYKEELIILDQMSIKGGMEGTRKMMQLKQRPDAIIGGDDFTALGIIKELSLLHITPPEVGVIGFANQTFSEFITPSLSTIDQQAVNMGKECANLFLKITNKKLAKNTIEKIVLPPLLVTRDSSGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH75</accession>
    <name>D7VH75_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997212.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10344"/>
    <dbReference type="EnsemblBacteria" id="EFK59427">
        <property type="protein sequence ID" value="EFK59427"/>
        <property type="gene ID" value="HMPREF0766_10344"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0727">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097451_0_0_10"/>
    <dbReference type="OrthoDB" id="1346400at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021458">
        <property type="entry name" value="DUF3109"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11307">
        <property type="entry name" value="DUF3109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="187" mass="21338" checksum="E3E8C9D9E3E55DFC" modified="2010-10-05" version="1">MIEVGSVLVHEDLIENDFVCNLSKCKGACCIEGDSGAPLKESELAVLAEIYPKVKPYMTEKGIQAVEEQGTHVIDLDGDLTTTCVDGNKECAYVTWENGVTKCAIEKAYEQGEIHWKKPISCHLYPIRTTHYPEFDVLHYDRWHICKDACSFGKELQVPVYKFLKDPLIREYGENWYQELENTIESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHE6</accession>
    <name>D7VHE6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997384.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10415"/>
    <dbReference type="EnsemblBacteria" id="EFK59498">
        <property type="protein sequence ID" value="EFK59498"/>
        <property type="gene ID" value="HMPREF0766_10415"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033DPQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2095306_0_0_10"/>
    <dbReference type="OrthoDB" id="1912754at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="109" mass="12919" checksum="CA08BB68C93825DE" modified="2010-10-05" version="1">MNEHSKNHTTSKLVAKVLLRLFIIILGLAAFPFVSGKSQQLDKSYVYFEHKWFLVFPFLLFAIFVVLLIIMLKEKYKKTDINWLFSLSALMLIGYLIMLYTRIYPMFNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHH0</accession>
    <name>D7VHH0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">infA</name>
        <name evidence="5" type="ORF">HMPREF0766_10439</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997456.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10439"/>
    <dbReference type="EnsemblBacteria" id="EFK59522">
        <property type="protein sequence ID" value="EFK59522"/>
        <property type="gene ID" value="HMPREF0766_10439"/>
    </dbReference>
    <dbReference type="GeneID" id="66690508"/>
    <dbReference type="eggNOG" id="COG0361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151267_1_0_10"/>
    <dbReference type="OrthoDB" id="2066663at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="72" mass="8336" checksum="78AA6B15B6A2B14C" modified="2010-10-05" version="1">MAKQASIEQDGIIREALSNAMFRVELENGHEIIAHISGKMRMHYIKILPGDKVKLEMSPYDLTKGRITYRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHN5</accession>
    <name>D7VHN5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Acylphosphatase</fullName>
            <ecNumber evidence="3 4">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">acyP</name>
        <name evidence="7" type="ORF">HMPREF0766_10504</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="3 4"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997581.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10504"/>
    <dbReference type="EnsemblBacteria" id="EFK59587">
        <property type="protein sequence ID" value="EFK59587"/>
        <property type="gene ID" value="HMPREF0766_10504"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141932_1_0_10"/>
    <dbReference type="OrthoDB" id="2034659at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="6">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="93" mass="10307" checksum="CB5F4FA3840F63BB" modified="2010-10-05" version="1">MKHWNISVRGKVQGVYFRLTTKAVADQLGVKGFVSNLPDGSVYIEAEGDDFALASLLEFCEEGPERAEVAEVSATDGEWKGFRNFEVLKKVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHX0</accession>
    <name>D7VHX0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10589"/>
    <dbReference type="EnsemblBacteria" id="EFK59672">
        <property type="protein sequence ID" value="EFK59672"/>
        <property type="gene ID" value="HMPREF0766_10589"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3066348_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="53" mass="6055" checksum="AC718928178CD348" modified="2010-10-05" version="1">MNKSTSIMPKDVFKVLLSIFHKKSEISDRGVFFSVMMSATDDIKKALFMLNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHX6</accession>
    <name>D7VHX6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OmpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_10595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997822.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10595"/>
    <dbReference type="EnsemblBacteria" id="EFK59678">
        <property type="protein sequence ID" value="EFK59678"/>
        <property type="gene ID" value="HMPREF0766_10595"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016890_6_0_10"/>
    <dbReference type="OrthoDB" id="2018797at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039567">
        <property type="entry name" value="Gly-zipper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13488">
        <property type="entry name" value="Gly-zipper_Omp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107152" evidence="3">
        <location>
            <begin position="23"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="102"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="230" mass="23409" checksum="6AC532E6102ABC2A" modified="2010-10-05" version="1">MIMKVNKKIAVFGLTLATSAMLFGSCSTIQNMNSTTKGAAIGTAGGGALGALIGGKAGNTAVGAIAGAVIGGAAGALIGKKMDKQAAEIENTVAGAEVIKSDEGIIVKFDEGILFDFNKSDLKASAKTNISKLVATLNKEPDTKILVIGHTDNIGSLAANQKVSEARAAAVKTYAVSQGLNGGRINTEGKNYSEPLASNDTDAGRAENRRVEIVIVAGDKMKQDAINATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHZ6</accession>
    <name>D7VHZ6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997862.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10615"/>
    <dbReference type="EnsemblBacteria" id="EFK59698">
        <property type="protein sequence ID" value="EFK59698"/>
        <property type="gene ID" value="HMPREF0766_10615"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_547352_0_0_10"/>
    <dbReference type="OrthoDB" id="2126915at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="498" mass="55023" checksum="8AEBBE932FECAFEE" modified="2010-10-05" version="1">MKADIQHLFILFISGLLLFTSCKQDELIFPDVVQTEETVTTTRPTARPNNLTLFSNYNQQIEIFWPAVSDRVKKATVTYQEASGTKSVDVVSFDKPTVLAVEQEKEYSINIVYYTADNTPSKTSTIKITSKPFENEFKAKGVTMLASPGGVRFIFPSTTAKQFEYKIKYQVDGQPKEKTVTSSELDVIVEVMGLNDETKAYDFDITVTDKVLNLTSKSYPYSQRPGILPYKEIAASVSMSGYFNKGQIFWSNGSGKNVNFEISYLLNGAPQKLTIPNTAVENGNYIFAINTTATAIAVKVTGEEGLSTVVNGSVAPSQLKAFNTADARKGWTPYASNSNSTSEGPPSFMLDASTSTIWHTQWSTTTTSSHPADQKYPFTLIFTFTKTRAASASGLFNEAALRTPAAPYDPIVVKEISLLHRSASNRVVKDVRVYGIDLQGKEIDFGQFTLSNTVQETKLALNNNEILKAVKIVCLTTFSTTNQFANFNEIYLTGYPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI07</accession>
    <name>D7VI07_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_10626</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997885.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10626"/>
    <dbReference type="EnsemblBacteria" id="EFK59709">
        <property type="protein sequence ID" value="EFK59709"/>
        <property type="gene ID" value="HMPREF0766_10626"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106921" evidence="5">
        <location>
            <begin position="21"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="61"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="388"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="970" mass="110267" checksum="48A78F66492C738F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI98</accession>
    <name>D7VI98_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA polymerase III, epsilon subunit</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dnaQ3</name>
        <name evidence="2" type="ORF">HMPREF0766_10717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998067.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10717"/>
    <dbReference type="EnsemblBacteria" id="EFK59800">
        <property type="protein sequence ID" value="EFK59800"/>
        <property type="gene ID" value="HMPREF0766_10717"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047806_14_1_10"/>
    <dbReference type="OrthoDB" id="1985371at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="5"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="203" mass="23129" checksum="F0D1305726D4507E" modified="2010-10-05" version="1">MALQSFIAIDFELATAAYNSVCSVGIVRVDQGVITDEFYSLVKPPKNEYMWQTTRVHGIKPKDTADAPTFEEIYPKIKDLLQNRKMVAHNEKFDREVLSKTMKACGLDYRELHLPVMWECTSKIYRDKGFKKTKLNLCCEIMGIDLNHHEALSDAKAAAFLYLKQNEVTQELLDRVFPAEELLIQPDEIAKKSESHNGSDGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VID0</accession>
    <name>D7VID0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeS assembly protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sufB</name>
        <name evidence="3" type="ORF">HMPREF0766_10749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10749"/>
    <dbReference type="EnsemblBacteria" id="EFK59832">
        <property type="protein sequence ID" value="EFK59832"/>
        <property type="gene ID" value="HMPREF0766_10749"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="158"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="499" mass="55661" checksum="D92D096FD643F715" modified="2010-10-05" version="1">MKLSDNTQKILIKSRDMSTKDDDILKELEQEEYKYGFTTDIEMDIAPTGLTEDTVRLISEKKNEPEWLLEWRLKAFRHFLTLKMPTWQNFRNPDVDFQAISYYAAPKAKPQLNSLDEVDPELLSTFAKLGIPLDEQKILAGVVAVDAVFDSVSVKTTFREKLKEQGVIFCSFGEAVQEYPELVKEYLGTVVPQTDNIYAALNSAVFSDGSFVYIPKGVRCPMELSTYFRINAQNTGQFERTLIIADEGSYVSYLEGCTAPTRDENQLHAAVVELVAQRDAEIKYSTVQNWYPGDKDGKGGIYNFVTKRGICKGDNSKISWTQVETGSAITWKYPGVILKGDNSVGEFYSVALTRNMQVADTGTKMIHLGKNTRSKIVSKGISAGKSHNSYRGLVKIGPNADNSRNFTQCDSLLIGDKCGAHTFPYIENKNRTAVLEHEATTSKIGEDQVFYLNQRGIDSEKAVGLIVNGYAKEVLNQLPMEFAVEAQKLLAISLEGSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIG9</accession>
    <name>D7VIG9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998205.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10788"/>
    <dbReference type="EnsemblBacteria" id="EFK59871">
        <property type="protein sequence ID" value="EFK59871"/>
        <property type="gene ID" value="HMPREF0766_10788"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161197_0_0_10"/>
    <dbReference type="OrthoDB" id="1907687at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="127" mass="14545" checksum="E650B8DA10EA4E75" modified="2010-10-05" version="1">MDYTQREKLIRNYVEAYNQLDIAGMLADLDDEIRFVNITDGEINLSLLGRRAFWDQAVQAAELFSERKQEILAVQHSPEQTEIEIDYSAKLAVDLPNGYERGQVISMKGRSIFRFGTDKIISLTDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VII1</accession>
    <name>D7VII1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Efflux ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0766_10800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998226.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10800"/>
    <dbReference type="EnsemblBacteria" id="EFK59883">
        <property type="protein sequence ID" value="EFK59883"/>
        <property type="gene ID" value="HMPREF0766_10800"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_10"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="25"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="321"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="415" mass="44659" checksum="1944F1F88AFFD028" modified="2010-10-05" version="1">MSVNMSYRENVKLALQSIVSNKLRTFLTALIIAIGITALIGVLTSIDAIQSSLTNSFSSMGSNSFNIRNRGLNVRIGDQGSKPKVYPAITYKQALEFKDRFSTDAIVSINANVTWASTVKFKSEKTNPNIGVIGGDDNYLQTSGYKIADGRNFTKQDVELGSAVVIIGKEITTKLFKNNTNPLGQYITVGDDRFLVIGVLESKGSSAGFGADKACFVPISKARMMMENANPSYVITVMSPDPLRMDAAEGEAILTFRKIRGLNARQTSNFEIIKSDAVAQMLMQNLNYVTYGAIAIAAITLLGASIGLMNIMLVSVTERTREIGVRKAIGATPGVIRKQFLMEAIVICILGGLAGIILGISIGNLLAVALGASFIIPWKWMFLGMAVCIFVGVVSGYYPASKASGLDPVEALRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIK7</accession>
    <name>D7VIK7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Renal dipeptidase family protein</fullName>
            <ecNumber evidence="2">3.4.13.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dpeP</name>
        <name evidence="2" type="ORF">HMPREF0766_10826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998275.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10826"/>
    <dbReference type="EnsemblBacteria" id="EFK59909">
        <property type="protein sequence ID" value="EFK59909"/>
        <property type="gene ID" value="HMPREF0766_10826"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031404_2_1_10"/>
    <dbReference type="OrthoDB" id="1145595at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000180">
        <property type="entry name" value="Dipep_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="PTHR10443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00869">
        <property type="entry name" value="RENAL_DIPEPTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107185" evidence="1">
        <location>
            <begin position="24"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="389" mass="43661" checksum="644073908EE736FD" modified="2010-10-05" version="1">MIKTVKQLTFGITLMSAFSVVSAQDYKQIHKDLIVVDGHNDVIYESIFKGKDIAKRLTTGHTDLPRLKEGGVDVQVFAVWSDDKNWKKGAFKHANDQIDALEKMISGNSDQIELAKSSKDIDAILNKGKIAAVIGVEGGNMIESKIENLEKLYDRGVRYLTLTWNYNLPWVTAAAIEVKTSSDKGKGLTAHGKDIIRRMNELGMMVDLSHGGEKTFYDVIATSTKPILVSHSNAYTLMPHYRNLKDEQLEALKKNGGVIGVNFYSGFLDPTYTERVRKLYRKHFGDKGNYKLSPTRQYEKLPKKLQQEANAPMSKLLEHINYLVKKVGVDHVAIGSDYDGIESPPRELDDVSKFPLLTKALLEQGYSKEDVGKIMGGNFLRLLRENEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIQ6</accession>
    <name>D7VIQ6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II</fullName>
            <ecNumber evidence="11">5.4.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pgcA</name>
        <name evidence="11" type="ORF">HMPREF0766_10875</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="11"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998381.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10875"/>
    <dbReference type="EnsemblBacteria" id="EFK59958">
        <property type="protein sequence ID" value="EFK59958"/>
        <property type="gene ID" value="HMPREF0766_10875"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_0_0_10"/>
    <dbReference type="OrthoDB" id="637615at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="49"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="211"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="325"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="490"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK59958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="577" mass="63695" checksum="37611C14116ED2E3" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIU0</accession>
    <name>D7VIU0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998452.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10909"/>
    <dbReference type="EnsemblBacteria" id="EFK59992">
        <property type="protein sequence ID" value="EFK59992"/>
        <property type="gene ID" value="HMPREF0766_10909"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033F1U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2496304_0_0_10"/>
    <dbReference type="OrthoDB" id="1968049at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="87" mass="9757" checksum="C617018719A38E08" modified="2010-10-05" version="1">MQKNNFLIGIALGIIAPVIAYLLTTYTSLETMLSANKPAMLYFIAGLVNLVMLRYFYRNDKEQTARGIMLVTFAGTVILIYTLKIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIU4</accession>
    <name>D7VIU4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998460.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10913"/>
    <dbReference type="EnsemblBacteria" id="EFK59996">
        <property type="protein sequence ID" value="EFK59996"/>
        <property type="gene ID" value="HMPREF0766_10913"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_696291_0_0_10"/>
    <dbReference type="OrthoDB" id="982403at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032342">
        <property type="entry name" value="DUF4861"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16153">
        <property type="entry name" value="DUF4861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107001" evidence="1">
        <location>
            <begin position="23"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="371" mass="41679" checksum="5FB5960BC9BD3138" modified="2010-10-05" version="1">MKKTFIAAFVALALAHSLSAQQKIVVKNPGNHSRHELISIPYSSFTKHFKVDSVFTIVNAADGSEVAHQLEKLGQSFPQNVLVEVNVAEQQELTLTVKPQKGTAFQVRTYARYVPERKDDFAWENDIAAYRAYGKALEGTSEDAQGFDFWSKRTSELVIDEWYKTGDYHADHGKGLDYYSVGQTLGVGDLALFVNGSIKFTKHYRKFEVLDNGPIRSTFRLIFEPQEIEGNTIELSKTISIDAGSQLNKIQVELKNNKKSSTDVVIGLSRRGEEKPAYQFADNSLAYWEPTLADKGTTGTAVLFGKDKITLDTTDPKQFLVHTTIPGNKKFVYYNGAAWDRAGKITTAQEWFDYVKQQQQNISKPLKVTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIZ8</accession>
    <name>D7VIZ8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10967"/>
    <dbReference type="EnsemblBacteria" id="EFK60050">
        <property type="protein sequence ID" value="EFK60050"/>
        <property type="gene ID" value="HMPREF0766_10967"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_347750_0_0_10"/>
    <dbReference type="OrthoDB" id="98528at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107007" evidence="1">
        <location>
            <begin position="22"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="814" mass="91035" checksum="9D41E7B5146B7B69" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJC1</accession>
    <name>D7VJC1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11090"/>
    <dbReference type="EnsemblBacteria" id="EFK58974">
        <property type="protein sequence ID" value="EFK58974"/>
        <property type="gene ID" value="HMPREF0766_11090"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2304235_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="100" mass="11446" checksum="F995D8AFE2583DD1" modified="2010-10-05" version="1">MFNLNTIKIKKLILIGCLLIAISSCQKETIVNSEVKKKESDEISKEIEDLKLFLGERLSIPVSKFKFNESDSTLYVENTAIKEKISVLRRFNNVINKPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJH3</accession>
    <name>D7VJH3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="11">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">cysS</name>
        <name evidence="13" type="ORF">HMPREF0766_11142</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000646.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11142"/>
    <dbReference type="EnsemblBacteria" id="EFK59026">
        <property type="protein sequence ID" value="EFK59026"/>
        <property type="gene ID" value="HMPREF0766_11142"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_0_1_10"/>
    <dbReference type="OrthoDB" id="952207at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="12">
        <location>
            <begin position="371"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="283"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFK59026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="488" mass="55522" checksum="68423570E8A9C00E" modified="2010-10-05" version="1">MENNLVLYNTISRKKEKFNPIHPSMVGMYVCGPTVYSDVHLGNCRTFVSFDLIFRYLLHLGYKVRYVRNITDAGHLEGDRDEGDDKFAKKAKLEQLEPMEIVQKYTIGFHDVLRLFNTLPPSIEPTATGHISEQIEMIKQIIDNGYAYEVNGTVYFDVEKYVQKYDYTVLTNRKLEDLLNNTRELGGQDEKRGRLDFALWIKAKPEHIMRWPAPWSTGFPGWHIECSAMSNKYLGAQFDIHGGGMDLAATHHTNEIAQSEACNHTSPARYWMHTNMLTVNGARMSKSSGNGFLPQELFTGNHPLLERGYSPMAVRFFMLQAHYRSTLDFSNEALDAADKGFKRLMNAIALLNKITPSKATSGFNLEDIRKNCYAAMDDDFNSPILIAELFEVVRIINSIYDGKSTINQKGLDELKAFMKDFVEDILGLNDDSNAGTDNMDELMNVIINIRNSAKQNKDFATSDRIREELSSIGIQLKDSKDGTLWNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJL0</accession>
    <name>D7VJL0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000716.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11179"/>
    <dbReference type="EnsemblBacteria" id="EFK59063">
        <property type="protein sequence ID" value="EFK59063"/>
        <property type="gene ID" value="HMPREF0766_11179"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107296" evidence="1">
        <location>
            <begin position="29"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="125"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1035" mass="114969" checksum="F8C8380D0E07F184" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJT3</accession>
    <name>D7VJT3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nagZ3</name>
        <name evidence="8" type="ORF">HMPREF0766_11252</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000911.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11252"/>
    <dbReference type="EnsemblBacteria" id="EFK59136">
        <property type="protein sequence ID" value="EFK59136"/>
        <property type="gene ID" value="HMPREF0766_11252"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007082_5_0_10"/>
    <dbReference type="OrthoDB" id="727559at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20b" evidence="7">
        <location>
            <begin position="26"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="5">
        <location>
            <begin position="154"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="6">
        <location>
            <begin position="629"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="751" mass="85400" checksum="C0F02A8FF885D459" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK99</accession>
    <name>D7VK99_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxal-dependent decarboxylase, C-terminal sheet domain protein</fullName>
            <ecNumber evidence="3">4.1.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">speA</name>
        <name evidence="3" type="ORF">HMPREF0766_11418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.19" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999056.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11418"/>
    <dbReference type="EnsemblBacteria" id="EFK58701">
        <property type="protein sequence ID" value="EFK58701"/>
        <property type="gene ID" value="HMPREF0766_11418"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027243_2_0_10"/>
    <dbReference type="OrthoDB" id="164471at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008792">
        <property type="term" value="F:arginine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06830">
        <property type="entry name" value="PLPDE_III_ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002985">
        <property type="entry name" value="Arg_decrbxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43295">
        <property type="entry name" value="PTHR43295"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="2">
        <location>
            <begin position="65"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="1">
        <location>
            <begin position="314"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="463" mass="54351" checksum="63323AE8F2E8A3DD" modified="2010-10-05" version="1">MQSYQEFLDLSVGFPQDGFEIIDDELYFHDLNLMEMIETYGTPLRFTYLPIVSKKIQQAKILFQTAILKHNYRGSYKYCYCTKSSHFKHIVEEALKNDIHLETSSAFDMPMIDTLERQGTVTKDITVICNGFKTYQYKQYIIDMIHDGYKNIIPVLDNKEEFNLYDDEIELDEPCNLGIRIASEEQPDSQFYTSRLGIRSEDIIDFYNNKIADNPNFRVKLLHFFINSGISDTPYYWNELEKYVTLYCKFKKINPELDTLDIGGGMPFKDSLVHDFDYEYMVNEIVNRIKQICAHHEVMEPDIITEFGKYTVAEASGILYKVLGRKQQNDRERWFMIDGSFITNLPDVWALNQKYILLPINNWDSEYERVNLGGITCDGQDYYNQEAHMNSVFMPKTRKVQYLGFFHTGAYQDVLSGYGGIHHCLLPSPKHVLVRRNRDETFNYEVFGEEQNSKQVMKLLGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKB9</accession>
    <name>D7VKB9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11438"/>
    <dbReference type="EnsemblBacteria" id="EFK58721">
        <property type="protein sequence ID" value="EFK58721"/>
        <property type="gene ID" value="HMPREF0766_11438"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2221550_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="106" mass="12179" checksum="5AEDF9CCBED9C949" modified="2010-10-05" version="1">MAVKLSSLLLDADLFLISPRQLTSLPNDKTSFHAMWNIFFYNAGENSSRRSYEELLMSIWLLSNSIKTLRVNWRPCQMIKQVSIQCGISFFIMPVRTAADAVVNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKG3</accession>
    <name>D7VKG3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999233.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11482"/>
    <dbReference type="EnsemblBacteria" id="EFK58765">
        <property type="protein sequence ID" value="EFK58765"/>
        <property type="gene ID" value="HMPREF0766_11482"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7QJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049143_0_0_10"/>
    <dbReference type="OrthoDB" id="1609834at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031345">
        <property type="entry name" value="DUF5103"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17116">
        <property type="entry name" value="DUF5103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="436" mass="49975" checksum="F00589313659929F" modified="2010-10-05" version="1">MNKCIALGVVFFLIASISYGQKKKKKKDNDSDRSPKQELIYDNINYLPTIQSVQLYPGTAESTLPVIDLEQKNQLLLSFDDLRADIRNFYFSIEHCDANWMPSRLSPLEYAEGFNEGRIDNYSSSKATFQPYTNYQVNFPDEYVGPKLPGNYLLKVYEDADKSRLILTRKFYVIRKLMSLSAKVTPSTIVSLRNKNQKLDVFVKTGAVTITNPQRDLRVVALQNQRTDNMMSLSDPMFAGGSEINYNNSQTLDFKGNNEFRYVDLRSLKLGSERVSSIRIDSLVRVDLHPDEDNSTSTYASTFDENGKFYIRNMDQREATLEGDYAQVTFSLKTDQTVKGDIYIVGGFNNYQRTSAGKLHYNENLKLWQVVLPLKQGLYDYEYVLQDPSGKVITDAFSGSFYQTGNNYQILLYNRKIGTFWDELLGFGEVSINNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKK5</accession>
    <name>D7VKK5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytoene/squalene synthetase</fullName>
            <ecNumber evidence="1">2.5.1.32</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">crtB</name>
        <name evidence="1" type="ORF">HMPREF0766_11524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.32" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999347.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11524"/>
    <dbReference type="EnsemblBacteria" id="EFK58807">
        <property type="protein sequence ID" value="EFK58807"/>
        <property type="gene ID" value="HMPREF0766_11524"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1562">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037269_3_0_10"/>
    <dbReference type="OrthoDB" id="1449625at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016767">
        <property type="term" value="F:geranylgeranyl-diphosphate geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="283" mass="32988" checksum="9C57B8BEF65BD2E6" modified="2010-10-05" version="1">MDNLKIFNELSRLCSKKVTQLYSTSFSSAISVLHADLHRPIYSIYGFVRLADEIVDSFHGYNKKSLLDDFKRDTFGAIQSGVSINPVLHSFQWVVNTYHIDHHYIHAFFESMYADLDKKVWKDQNELNAYIYGSAEVVGLMCLHIFCEGDQELIKKLTPSAQALGAAFQKVNFMRDLREDTYDLGRRYFHDIQMDQFDKDTKIKIEQQITKDFEQAFDGLMQLPAKSRYGVLLAYRYYLCLFEKIKRLPPENILNKRIRVPDYQKLLLLLRISLGSRLATNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKP5</accession>
    <name>D7VKP5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane insertion signal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11564"/>
    <dbReference type="EnsemblBacteria" id="EFK58847">
        <property type="protein sequence ID" value="EFK58847"/>
        <property type="gene ID" value="HMPREF0766_11564"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071588_1_0_10"/>
    <dbReference type="OrthoDB" id="1636857at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045743">
        <property type="entry name" value="DUF6089"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19573">
        <property type="entry name" value="DUF6089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6089" evidence="1">
        <location>
            <begin position="20"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="284" mass="32212" checksum="7FEF0B71A58FE593" modified="2010-10-05" version="1">MKYIIFTAKKTILQRLFYSLLVLICFFPICNLSAQQWELGANLGTTGYMGDINPNNPLYFRSLGGGLTGKYNFNPTWGVKGGINYLHLFGSDANSSNERQIQRNLAFQNKVVEISAIGEFNFFRFVPGKNKLAYTPYIFAGVAAIYHNPYVKFSTGEKYDLRDLQLEYDAANNPGKYSKFALAIPFGAGFKYNIKGPWSVGAELNYRVVLSDNIDNVNRNYATSMKEGIEQQIDPLVWESLADRSGNWEANKGKLRGDGRPHDAYMTFGLTVTYTFISQKCYWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKS3</accession>
    <name>D7VKS3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Magnesium transporter MgtE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mgtE</name>
        <name evidence="9" type="ORF">HMPREF0766_11592</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a magnesium transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999469.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11592"/>
    <dbReference type="EnsemblBacteria" id="EFK58875">
        <property type="protein sequence ID" value="EFK58875"/>
        <property type="gene ID" value="HMPREF0766_11592"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037408_2_2_10"/>
    <dbReference type="OrthoDB" id="1239195at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00400">
        <property type="entry name" value="mgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="200"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK58875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="459" mass="51511" checksum="EAC657844D68F9EB" modified="2010-10-05" version="1">MENLEMQVERVEQLFESQNLEELAEYLNELNISDVEELIDELPEHAALFLEVLSLNRAVNVFRILDFPTQERVFKKLPPSKVREILNEMPPDDRTSFFSELKGDVVKQLIIMLTPQERKEALSLLGYPEDSVGRLMTPDYITVKEYWNMPRVLDHIRRYGNASETIDVLYVIDGNGKLIDDLRIRDVLIAKEDAVVGDLIDNRLISLKANDPQEEAVTVFRMNNRVALPVVDDQDIMLGIVTIDDILWVANEEYTEDMQRFGGTEALDEPYLDVAISHLVKKRAGWLVILFLGQLLTATVIEHFEAQLATVIALFALVPLIMSSGGNSGSQASTLIIQAMALGEVTLSDWWRVMKREFLSGLFLGLILGTLGFIRIATWQSFSHAYGDHWAIIGVVVSLSLVCVVLWGSLTGSMLPFLLKKLGADPASSSAPFVSTLVDVTGLLIYFTFVTLLLSEVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKT3</accession>
    <name>D7VKT3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase domain protein</fullName>
            <ecNumber evidence="2">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999489.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11602"/>
    <dbReference type="EnsemblBacteria" id="EFK58885">
        <property type="protein sequence ID" value="EFK58885"/>
        <property type="gene ID" value="HMPREF0766_11602"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070010_4_1_10"/>
    <dbReference type="OrthoDB" id="767622at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="7"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="227" mass="25041" checksum="D8786C9663D4268D" modified="2010-10-05" version="1">MKITYYGQSCVLFDFDGHQVLLDPFVTYNPIAEHVDVNALNPEYIFVSHAHQDHVADLLTVQKNSNAIVATVVETAAWVRKQGVPDDKVVEFNLGGTIETTFGKVKMVIAIHTNSTPDGAYGGWPVGYVFFAGDKKIYFAGDTALTYDMKLLEDLQLDWAFLPIGGHYTMDVEDAVKAAQFINCKHIVGIHYNTFPPITIDVEVAKRKFSDAGLQLSLPGIGETISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKT9</accession>
    <name>D7VKT9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999499.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11608"/>
    <dbReference type="EnsemblBacteria" id="EFK58891">
        <property type="protein sequence ID" value="EFK58891"/>
        <property type="gene ID" value="HMPREF0766_11608"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084727_0_0_10"/>
    <dbReference type="OrthoDB" id="1589192at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="288" mass="32381" checksum="19D6E9EC70C8932B" modified="2010-10-05" version="1">MILVADSGSSKSDWILDLPDSKPLTFSTKGLNPFFVSEKEIERVLKEVPEIIPYADEIKEVYFYGAGCVTPDRRELVSNALTQLFPSAFISVESDLLGSALATCGMNKGFIATMGTGSDVSFFDGELLLASHNGNGYVLGDEGSGAWFGKQLITSFLYGKMPVDLAGKFEEKYRISKDVVIKNVYQKERPNTYLANFAEFMDANRLHPFIDSLLRKGMDEFVKTNILTYPKYWEYECHFVGSIAFHFDLILRDVCRIHGVRVGSILKSPIQEIFSFVIEREKNSILDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKV6</accession>
    <name>D7VKV6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK58229">
        <property type="protein sequence ID" value="EFK58229"/>
        <property type="gene ID" value="HMPREF0766_11625"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3140832_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="49" mass="5511" checksum="CA20831CA2E75474" modified="2010-10-05" version="1">MAKVEIFFELHKSFLQKICPPVILNLLFSVVIPCETTIPPLRSGAKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL05</accession>
    <name>D7VL05_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999691.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11674"/>
    <dbReference type="EnsemblBacteria" id="EFK58278">
        <property type="protein sequence ID" value="EFK58278"/>
        <property type="gene ID" value="HMPREF0766_11674"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032U1C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1601114_0_0_10"/>
    <dbReference type="OrthoDB" id="1456026at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="178" mass="20616" checksum="85840D44A1B7B54B" modified="2010-10-05" version="1">MLKIKKSNSSLLKAYLLPLAGMLLIFGSCQRRSDIQGKGAEYLQGIWEQDSIPHQDQMLSYTLHSFKITCDSIYTTMDVHSTVQRMSDSCYQNGNWKEYAKAVYVVRGDSMIVEGVYTKENGKQKLSGCYKQGQYLPRFKIAKYSKDTLILENRFDQRPIVLHKKQDITCVPKKRWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLB5</accession>
    <name>D7VLB5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1338 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999967.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11784"/>
    <dbReference type="EnsemblBacteria" id="EFK58388">
        <property type="protein sequence ID" value="EFK58388"/>
        <property type="gene ID" value="HMPREF0766_11784"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053061_1_1_10"/>
    <dbReference type="OrthoDB" id="714422at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009770">
        <property type="entry name" value="DUF1338"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07063">
        <property type="entry name" value="DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01150">
        <property type="entry name" value="DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1338" evidence="1">
        <location>
            <begin position="9"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="302" mass="34467" checksum="EC341C56F6C3CC2D" modified="2010-10-05" version="1">MKFEENKPLDIVLNDLFEHYRKNVTAVGQITDALLQKGVVSSQEDIVNDHIAFRTLGVPHLGIASFEKIFLAYGYKKMDHYYFEGKKLDAYWFKPPGTDYPRIFVSELIVSQLSEEAQAIIHKYTDGITADPVDTLNLENGQETADFLQKPLWKLPSSSDYTRLLEESEYAAWVIFNRYYLNHYTISIHELKEGYNTLEEFNNFVEGLGIKLNTSGGKIKTSEDGLLRQSSTVSALYDAKFSDGVTLQIAGSYVEFAERSVLPEFKDTPRDQITAAQRRDGFETNNADKIFESTYTTQIKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLB7</accession>
    <name>D7VLB7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C4-dicarboxylate transporter DctA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dctA</name>
        <name evidence="8" type="ORF">HMPREF0766_11786</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999972.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11786"/>
    <dbReference type="EnsemblBacteria" id="EFK58390">
        <property type="protein sequence ID" value="EFK58390"/>
        <property type="gene ID" value="HMPREF0766_11786"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019375_7_0_10"/>
    <dbReference type="OrthoDB" id="781228at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046942">
        <property type="term" value="P:carboxylic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="414" mass="45410" checksum="993C36A2019064ED" modified="2010-10-05" version="1">MHNIFKNLTFQVLTAIILGVLAGIYFPGFADTARIISETFINMIKMVIAPIIFLTIVLGIASMGDMKKVGRVGGKALLYFEIVTTFALIIGLFVAHYTEPGRGVNFNHEGVADIQKYKNEAAEINWIEFFTHIVPSNVFKAFTDGNILQVLFFSILFGLGLTKLGEQGQPLLRSFDRFSKVLFNIMKMIMRLAPLGAFGGMAYTIGTHGIEALAPMGRLMLSVYATMILFIFVCLNIICRMYKFSLWKYLKFIKEEILIVLGTSSSESVLPNIMQKMEDFGCSRSVVGLVIPTGYSFNLDGTTIYLSMATIFLAQVFHVDLSFAQLLTIIGILLVTSKGAAAVTGGGFIVLAGTLTALKVIPVEGMAILLGVDRFMSEARAITNLIGNGVATVVIAKSEKEFDEEKYENAISEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLC9</accession>
    <name>D7VLC9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000005.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11798"/>
    <dbReference type="EnsemblBacteria" id="EFK58402">
        <property type="protein sequence ID" value="EFK58402"/>
        <property type="gene ID" value="HMPREF0766_11798"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032722_0_0_10"/>
    <dbReference type="OrthoDB" id="572473at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="542" mass="59558" checksum="2F0F01CAD8EFAA5F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLK8</accession>
    <name>D7VLK8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2Fe-2S iron-sulfur cluster binding domain protein</fullName>
            <ecNumber evidence="5">6.1.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lysS2</name>
        <name evidence="5" type="ORF">HMPREF0766_11878</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000199.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11878"/>
    <dbReference type="EnsemblBacteria" id="EFK58481">
        <property type="protein sequence ID" value="EFK58481"/>
        <property type="gene ID" value="HMPREF0766_11878"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1034">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_11_0_10"/>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="4">
        <location>
            <begin position="95"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="337" mass="37779" checksum="081B52CD88CAC80F" modified="2010-10-05" version="1">MAEDVKFKVSIDGIPVEVAPGTTILNAARQIGGDIVPPAMCYYSKLEGSGGKCRTCLVKVSKGSEKDPRPMPKLVASCRTTVMDGMEVLNITSPEVVEARKGVVEMLLINHPLDCPVCDQAGECKLQDLGYEHGSEGTRYEFDRRTFERIDIGDKIQLHMNRCILCYRCVFTADQITNNRVHGILNRGDHAEISTYIAKAVDNDFSGNVIDVCPVGALTDKTFRFKNRVWFTKPVDAHRDCPTCSGKVTLWNRGTEVLRVTARKDEFGEVEEFICNTCRFDKKHTDDWILEEPTPVDKDSVIGANHYPEFNPPPVIKPDLELQEANEEQLARTEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLM6</accession>
    <name>D7VLM6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000242.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11896"/>
    <dbReference type="EnsemblBacteria" id="EFK58499">
        <property type="protein sequence ID" value="EFK58499"/>
        <property type="gene ID" value="HMPREF0766_11896"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031482">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080664_5_0_10"/>
    <dbReference type="OrthoDB" id="1584631at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107391" evidence="1">
        <location>
            <begin position="26"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Stress-response A/B barrel" evidence="2">
        <location>
            <begin position="39"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="138" mass="15905" checksum="BC5D8EA22CA2D1C6" modified="2010-10-05" version="1">MKRRKFLQSSAATIGTSALAVSAFAQSKSSFAVVENGQIIHSVYFWLKEELTAQQVKDFTKFFEALRKVPNIKSLRYGRPAETSKRPVVDNSWTYNLIVVFEKMEYINTYETHPIHLKAIEDFSSNWTKVLVHDTQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLP6</accession>
    <name>D7VLP6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">rsgA</name>
        <name evidence="10" type="ORF">HMPREF0766_11916</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000288.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11916"/>
    <dbReference type="EnsemblBacteria" id="EFK58519">
        <property type="protein sequence ID" value="EFK58519"/>
        <property type="gene ID" value="HMPREF0766_11916"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033617_2_0_10"/>
    <dbReference type="OrthoDB" id="908180at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04466">
        <property type="entry name" value="S1_YloQ_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031944">
        <property type="entry name" value="RsgA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16745">
        <property type="entry name" value="RsgA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="78"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="8">
        <location>
            <begin position="87"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="181"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK58519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="306" mass="34148" checksum="D5F0E93BFBC8C0B9" modified="2010-10-05" version="1">MRGLVTKSTGSWYLVLGDDGRRYECRIKGKFRTHGIKSTNPVAVGDWVEFDLEPDLDSGVIRHLEPRRNYIIRRSVNLSKQTQIIGANLDQALLVVTLASPPTSLGFIDRFLVTAEAYSVPAMLVFNKLDLFSDEGLDILKEYEQIYESIGYPCYKVSALEGINVEELKDLLKDKVTLVSGHSGVGKSTLINALIPEAGLKTGSISDWSDKGKHTTTFAEMMDLPFGGKLIDTPGIRELGIVDIEPQELSHFFPEMRALLNKCRFNNCRHVNEPGCAVMEAVENGAIEASRYDSYLSIYHNENTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLS4</accession>
    <name>D7VLS4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000007">
        <property type="protein sequence ID" value="EFK58226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11944"/>
    <dbReference type="EnsemblBacteria" id="EFK58226">
        <property type="protein sequence ID" value="EFK58226"/>
        <property type="gene ID" value="HMPREF0766_11944"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3205431_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="45" mass="5296" checksum="688EDA574AB64530" modified="2010-10-05" version="1">MKLQPVISKENLFWLFGRVRERFRTSMEQPLCSSAPLLTASREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM06</accession>
    <name>D7VM06_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">dapA</name>
        <name evidence="11" type="ORF">HMPREF0766_12003</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001176.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12003"/>
    <dbReference type="EnsemblBacteria" id="EFK58011">
        <property type="protein sequence ID" value="EFK58011"/>
        <property type="gene ID" value="HMPREF0766_12003"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_7_0_10"/>
    <dbReference type="OrthoDB" id="1438588at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK58011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="292" mass="31620" checksum="CE4705DD26F38B28" modified="2010-10-05" version="1">MNELHGAGVALVTPFNAEGSIDFEALAQLIELQINEGMNYLVSLGTTGEVATLSKEERKRIWDFTAKQVNGRVPLVAGIGGNHTAEIVTQVQEFDHSAYCAILSVSPYYNKPTQEGIYQHYKAIATASKLPVILYNVPGRTGSNMTAETTIRLAKDFDNIVAIKEASANFAQFSAIMRDKPEGFLLISGDDPATLPMMALGAVGIISVVGNAYPAKVATLSRLCAEGNYADARQIHNELLEITDLCFIEGNPAGVKYILQQKGIGRDHVRLPLVPVSVRTQQAIEQEMKTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM69</accession>
    <name>D7VM69_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12066"/>
    <dbReference type="EnsemblBacteria" id="EFK58074">
        <property type="protein sequence ID" value="EFK58074"/>
        <property type="gene ID" value="HMPREF0766_12066"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_549689_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="177"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="496" mass="58651" checksum="D129108C7A26189B" modified="2010-10-05" version="1">MLRRIILLFSLILIIQCKEPEIIEWNSLINDYSKDDRDSLKLKSVLFLRNKFESRYSEKLLFMDKKNNRIKIRIDSIQNEATLMKYMQINKLESSVIKIKESEILNTKDIRRFIEEAVSSRERYSWSKGVSEDLFLKYVLPYKIEMEFPTEWRSYFERIQQGFLDSLDRTTDNSIENAAKLISKNIYQWYRYDKSNYLFSQQPDFNELLFSRKGECYRIARLFVYALRSAGIPATVDIVPKWGSKNAGHAEFVLLDSSGNLKANVTTEHKQGLCRASKVFRQNFSYSGLYTDSISPYLRNYPFKLDHFINDNTTDVTNEHTTCYDIKFNIPDKYSSSPFLYICVYNYGAWEPIFWSKNNNNIASFRKMTTNILYRIASPTENGIELLPNILFVTNKGEVQNIDHIYLKKKSKFHIIKINKFNDGERAHVESEKLYTLNLLLSNGEWKKLESKYPKNGRLSFRIIHSPNSFYKLTGENSIDYLARPFQYVNNKIIWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMA5</accession>
    <name>D7VMA5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001404.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12102"/>
    <dbReference type="EnsemblBacteria" id="EFK58110">
        <property type="protein sequence ID" value="EFK58110"/>
        <property type="gene ID" value="HMPREF0766_12102"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1052363_0_0_10"/>
    <dbReference type="OrthoDB" id="1786229at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107050" description="FAS1 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="39"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="218" mass="24647" checksum="4D132C4DAD07E63D" modified="2010-10-05" version="1">MKQQSILFVIMLLVTASLWSCAKTDGYYDYENKENIFTGNTIEYFQSKPQVYDSLLTVLNKFPALRDSIATTATTVFAPTNSSFHSAITNLNLVRKTQNKPLLYIRDLDPVQLDTLISKYISEDLVTTDSMLFVDGLFINARYNQDMHAQRIKQESSGFVGGGLVTVYYSDTKGSNFQSQWTRTTTQAVNIKTSNGVVHILNNGHEFGFGEFLTRFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMA8</accession>
    <name>D7VMA8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe-S metabolism associated domain protein</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sufE</name>
        <name evidence="3" type="ORF">HMPREF0766_12105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SufE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001411.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12105"/>
    <dbReference type="EnsemblBacteria" id="EFK58113">
        <property type="protein sequence ID" value="EFK58113"/>
        <property type="gene ID" value="HMPREF0766_12105"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124502_0_0_10"/>
    <dbReference type="OrthoDB" id="1996347at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003808">
        <property type="entry name" value="Fe-S_metab-assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43597">
        <property type="entry name" value="PTHR43597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02657">
        <property type="entry name" value="SufE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SufE" evidence="2">
        <location>
            <begin position="11"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="139" mass="16071" checksum="2285170FF3F96590" modified="2010-10-05" version="1">MTINEIQDELIEDFSFFEDWMQKYEYIIQLGKELPLVDEQYKTEDYTIKGCQSKVWLHPDMEDGKIIFKADSDAVITKGLVSLMVKVLSGHTPKEIVESDLYFIDRIGLREHLSPTRANGLLSMVKQMKLYAVALHAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMJ2</accession>
    <name>D7VMJ2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992616.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12212"/>
    <dbReference type="EnsemblBacteria" id="EFK57139">
        <property type="protein sequence ID" value="EFK57139"/>
        <property type="gene ID" value="HMPREF0766_12212"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_87_1_10"/>
    <dbReference type="OrthoDB" id="1757088at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="167"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="270" mass="31683" checksum="79D7E8C656668F3A" modified="2010-10-05" version="1">MEAKYVDRYYMTEVDAFEDSIYCHHKVMGESFIAEHMHQKGQFLYTEGGVVFLKTPDKSFFLPARHYIWIPSGMKHSIHPSSPEVIMRNLYFPKFETDTDFFDKINIYPVNDLLIELIMFTNRWNGNIFPVEEPKYSIAKAFKLILPELSQTELPLALPYPSHTKLKDIITYLDSRIEENVSFKDVAKQFDISERTLARLFQKELNMSFIQYYTILRMLKALKLLLDEKLTVNEVALKVGYSSLPTFSNTFNKIVGLRPSEYVKHKNHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMP7</accession>
    <name>D7VMP7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KDPG and KHG aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992724.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12267"/>
    <dbReference type="EnsemblBacteria" id="EFK57194">
        <property type="protein sequence ID" value="EFK57194"/>
        <property type="gene ID" value="HMPREF0766_12267"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0800">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077795_2_0_10"/>
    <dbReference type="OrthoDB" id="1497385at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="221" mass="24480" checksum="C61F3C1F4042935B" modified="2010-10-05" version="1">MSNKRQIVLDAILQQGMLPLFYQDSEEGTIALVRVLYKAGIRVFEYTNRGEFALNNFKKLIAVRDQELPGLYIGIGTITNAGQAEDFVTAGADFLVAPTINPDVAAIAKKNELLWIPGCMTPTEISLAQQHQAALIKIFPANILGPEFISSIRDLFRGQLFMPTGGVELHIDNLRKWFKSGVCAVGMGSKLISQEVIEKGLYDELYDNTVLALQLVQESKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN75</accession>
    <name>D7VN75_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12445"/>
    <dbReference type="EnsemblBacteria" id="EFK57372">
        <property type="protein sequence ID" value="EFK57372"/>
        <property type="gene ID" value="HMPREF0766_12445"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZNYQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2791855_0_0_10"/>
    <dbReference type="OrthoDB" id="2097982at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="68" mass="8076" checksum="B1468E742881BE4C" modified="2010-10-05" version="1">MTSLEELKQLFESQDLPTEIRIAPHMYVTNVREFLRVSFNACESWKKELNKCPSYLMLIKLKEALENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNI0</accession>
    <name>D7VNI0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase, M48 family</fullName>
            <ecNumber evidence="10">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0766_12550</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="10"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993129.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12550"/>
    <dbReference type="EnsemblBacteria" id="EFK57477">
        <property type="protein sequence ID" value="EFK57477"/>
        <property type="gene ID" value="HMPREF0766_12550"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074068_0_1_10"/>
    <dbReference type="OrthoDB" id="1530824at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107156" evidence="8">
        <location>
            <begin position="23"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="9">
        <location>
            <begin position="101"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="231"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK57477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="269" mass="29550" checksum="45D2EF6F562A07C3" modified="2010-10-05" version="1">MNSYFILLVMIKKILLTSCAVALLSSVSYGQFKLNSKTVGSATKAVKAVTLSNEDVVKYTKEYIEWMDENNPVAPDNDELAIRLKKLTSGLNNYDGLDLNFKVYLVRDVNAFACADGSVRVCAGLMQVMTDEEVLSVIGHEIGHVKNEDSKDAFRTALLTSALKDGVSSQGGTAAALSESQLGALSEQIANSSFSRKQESLADDYGYEFLKKQKSNPWYMAKAFEKLNELSGGEKQSATQKLMSSHPDTPKRVETMSKKAEKEGFKKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNK0</accession>
    <name>D7VNK0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PRTRC system protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993152.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12570"/>
    <dbReference type="EnsemblBacteria" id="EFK57497">
        <property type="protein sequence ID" value="EFK57497"/>
        <property type="gene ID" value="HMPREF0766_12570"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZANB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085624_1_0_10"/>
    <dbReference type="OrthoDB" id="813726at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032787">
        <property type="entry name" value="Prok-E2_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022280">
        <property type="entry name" value="PRTRC_protein-B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14460">
        <property type="entry name" value="Prok-E2_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03737">
        <property type="entry name" value="PRTRC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="237" mass="27129" checksum="8A762FA3014748EB" modified="2010-10-05" version="1">MKDITQNFGTLYHPLSALVFYQTKGSNRTTYVEHFDMDRNGNPINAHPLTEREAKELAKALNTEKEKSKAFLKSNGILPTNVLHINPSENGTVLWYTKARKVKMFFTESLEIPNGTAKVPAMLWYASKQSLIVFALEKDRRPTENTVLFHAPFFNIYEDGHVCMGTVDINIKNSASVEEFMQAWESYFFNSYFSHLVNEHNPIKGNCVSLWKDLIGTDKAFPKDILKKTNKTIKTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNL0</accession>
    <name>D7VNL0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993164.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12580"/>
    <dbReference type="EnsemblBacteria" id="EFK57507">
        <property type="protein sequence ID" value="EFK57507"/>
        <property type="gene ID" value="HMPREF0766_12580"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_326223_0_0_10"/>
    <dbReference type="OrthoDB" id="65564at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="883" mass="102301" checksum="51DA8A9308BD8EDE" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNM0</accession>
    <name>D7VNM0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993177.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12590"/>
    <dbReference type="EnsemblBacteria" id="EFK57517">
        <property type="protein sequence ID" value="EFK57517"/>
        <property type="gene ID" value="HMPREF0766_12590"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113992_0_0_10"/>
    <dbReference type="OrthoDB" id="1138684at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025415">
        <property type="entry name" value="DUF4141"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13605">
        <property type="entry name" value="DUF4141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107388" evidence="1">
        <location>
            <begin position="23"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="210" mass="23810" checksum="32A6B483D4CD0A9D" modified="2010-10-05" version="1">MKKVMYLVCTALMLAVAPSAKAQWVVTDPANLASGIINSANEIIQTSSTVSNVIKNFNEVKKVYDQGKEYYDKLKAINNLVKDARKVQQTVLLVGDVSEMYVQNFGKMMNDPNFSPQELVAIGNGYSALLNESTELLKELKQIVTSSSLSLNDKERMDIIDRVYKEVKDYHSLVRYYTTKNISVSYLRAKKKNDAQRVLELYGTANQKYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNQ0</accession>
    <name>D7VNQ0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative XkdX family protein</fullName>
            <ecNumber evidence="5">2.4.2.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">deoA</name>
        <name evidence="5" type="ORF">HMPREF0766_12620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.4" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12620"/>
    <dbReference type="EnsemblBacteria" id="EFK57547">
        <property type="protein sequence ID" value="EFK57547"/>
        <property type="gene ID" value="HMPREF0766_12620"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0213">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_888274_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009032">
        <property type="term" value="F:thymidine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017872">
        <property type="entry name" value="Pyrmidine_PPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="PTHR10515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00647">
        <property type="entry name" value="THYMID_PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="4">
        <location>
            <begin position="102"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="3">
        <location>
            <begin position="169"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="313" mass="33990" checksum="739B065207927283" modified="2010-10-05" version="1">MENQSNILKYKHLGIYTQNENVVYMHENCHVCASEGFEALTRIRISTATDSIVASLNVISSNLLLTDEIGLSDAAAKKLNVSPNETLYVSHLEPIKSLSHVRAKIYNQKLDYLAYNEIITDIVQGNYSNIDLTAFITACAGNRMDLDEITYLTKAMIASGMQLHWNKEIVVDKHCIGGLPGNRTTPLVVAIVTAFGLTMPKTSSRAITSPAGTADTMEVFTNVTLSPEKIKEVVHKEGGCIVWGGTAQLSPADDLLIKIEKALDIDSEGQLIASVLSKKAAAGSTHVVIDIPVGETAKMRSTKMAQTKSIWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNS8</accession>
    <name>D7VNS8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993270.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12648"/>
    <dbReference type="EnsemblBacteria" id="EFK57575">
        <property type="protein sequence ID" value="EFK57575"/>
        <property type="gene ID" value="HMPREF0766_12648"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141598_0_0_10"/>
    <dbReference type="OrthoDB" id="1951122at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107166" evidence="2">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="139" mass="15500" checksum="185CE3011FB5B236" modified="2010-10-05" version="1">MNKIIIGFISLLTLLFTACGQAGSNKDEAEQQHSQATPESNGHTTQIGELVPSDEVCMVNDAYMGKRQFDVKFDGKTYYGCCEMCKERIPKDATVRMAIDPYSHKQVDKANAVIAVTGNNGEVSYFENKENYAKYVKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNT2</accession>
    <name>D7VNT2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phage tail component domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rteC</name>
        <name evidence="1" type="ORF">HMPREF0766_12652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12652"/>
    <dbReference type="EnsemblBacteria" id="EFK57579">
        <property type="protein sequence ID" value="EFK57579"/>
        <property type="gene ID" value="HMPREF0766_12652"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZAA7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079317_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018534">
        <property type="entry name" value="Tet_reg_excision_RteC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09357">
        <property type="entry name" value="RteC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="280" mass="34083" checksum="F1E15B982CD03353" modified="2010-10-05" version="1">MKRMDKFYNETYLKLETEIQELEIENDNPVQRTEAIIYRIVECLSEIKDYVLKRGFTNVDEEIRFFKYQKPVIVSKLIYYNAIYKIETRKPYGAKRIRKYLKKELKKLKRFFDNNIDFYKYYRSNNSFLDEKMFVRGKHDIKLWLDTYYFQSDQSFSTSHDYKVAKIMANDLIQVYLEDQLYCTYKRLFIKRTAISGLNWTGSKAALTELIYSLYYQSVLDNGNTDIRLIAEYFENAFNIDLGNFYHTYLEIRNRKRNRTKFLDALRDNLIKKMDEQEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNZ9</accession>
    <name>D7VNZ9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993388.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12719"/>
    <dbReference type="EnsemblBacteria" id="EFK57646">
        <property type="protein sequence ID" value="EFK57646"/>
        <property type="gene ID" value="HMPREF0766_12719"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_13_1_10"/>
    <dbReference type="OrthoDB" id="949250at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045800">
        <property type="entry name" value="HMBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19335">
        <property type="entry name" value="HMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMBD" evidence="3">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="2">
        <location>
            <begin position="104"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="402" mass="44536" checksum="091C102490548B43" modified="2010-10-05" version="1">MKSSVIKIGILLSIVTILWSCTGTPEKKNEPTAEETKQTYTCPMHPQVIKHEMSTCPICGMDLVPFEKNSADKSVRLDEQRQLLANIATIRVGNEGIVLPQKVLNGRLVLNPEHSNYISAKIAGRVEQLYIRETGVIIKKGQPLYILYSEELATLQQEYLMAVAQQRQFESDKLEQQLLASAKQKLLLYGQTEQQIQQLAKTGQKSPLVTVLATQSGTVAELSITQGQYVAEGGPIMRLENYGQLWVEADLYPNEAKQIVQGQRLKVIVVGWEDQEQWMKVDFINPSLQSGTQLTQIRGSIANAKQQWQPGLQVQVLLTNATKSADGIVLPVDAVINDGKGQHVWIKTGADSFEPKSVITGITNQDQVSIISGLQEGEEVVVTGAYLLYSEYILKRGMHPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP60</accession>
    <name>D7VP60_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATPase family associated with various cellular activities (AAA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0766_12780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993483.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12780"/>
    <dbReference type="EnsemblBacteria" id="EFK57707">
        <property type="protein sequence ID" value="EFK57707"/>
        <property type="gene ID" value="HMPREF0766_12780"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_1_10"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="9">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="8">
        <location>
            <begin position="438"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="824"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK57707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="849" mass="95012" checksum="A842BA5861504965" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPA4</accession>
    <name>D7VPA4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">murA</name>
        <name evidence="9" type="ORF">HMPREF0766_12824</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993581.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12824"/>
    <dbReference type="EnsemblBacteria" id="EFK57751">
        <property type="protein sequence ID" value="EFK57751"/>
        <property type="gene ID" value="HMPREF0766_12824"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027387_0_1_10"/>
    <dbReference type="OrthoDB" id="537477at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK57751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="441" mass="48202" checksum="5D43F58B2CD040A9" modified="2010-10-05" version="1">MNAFEIHGGKPLKGEIIPQGAKNEALQIISAVLLTEEPMTIANVPDIKDVNKLIELLQALGVKVNRVDQDTYVFEAKDINIDYFQSEEFKVKGGGLRGSIMIVGPLLARFGKAAIPKPGGDKIGRRRLDTHFLGFEKLGAKFVYDADNNFFNVDASELRGTYILLDEASVTGTANIVMAAVLAKGTTTIYNAACEPYLQQLCKMLNRMGANISGIGSNLLTIEGVERLGGTSHKMLPDMIEIGSFIGLAAMTGSEITIKDVCYPELGIIPTIFSRLGIKMELRGDDIFIPAQEHYEIETFIDGSILTVSDAPWPGFTPDLLSIVLVTAIQAKGNVLIHQKMFESRLFFVDKLIDMGAQIILCDPHRATVIGLDKAFKLRGIEMTSPDIRAGVSLLIAALSAQGKSKIYNIEQIERGYQHIEERLKALGADIRRIDETPAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPF2</accession>
    <name>D7VPF2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cadmium, cobalt and zinc/H(+)-K(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">czcD</name>
        <name evidence="8" type="ORF">HMPREF0766_12872</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993654.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12872"/>
    <dbReference type="EnsemblBacteria" id="EFK57799">
        <property type="protein sequence ID" value="EFK57799"/>
        <property type="gene ID" value="HMPREF0766_12872"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_0_0_10"/>
    <dbReference type="OrthoDB" id="948593at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="219"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK57799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="315" mass="34855" checksum="CEC778495F72D0C9" modified="2010-10-05" version="1">MGNNHEHSQSHTANKKTLTISLVIITFYMAVEVIGGLITNSLALLADAGHMLSDAISLFIALMAFTFSNKVADYGKTYGYKRFEILAAVINGATLILISAYIIYEAVERFQNPPEIASKGMLIIAFIGLLINVLVAWIMMRGADVKENLNMRGAYLHVLSDMLGSVGAIIAALLIMFFGWGWADPLASVIVSLLVLRSGYIVTKSAIHVLMEGTPNNVEVEKVTKKMLSTKGINNIHDLHIWTITSGLNALTCHAVVDEKMTIEESEKMLRKIEHDLEHLNIHHITIQLETSANQHNNSILCNIRAEPTKHEHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPP2</accession>
    <name>D7VPP2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protoporphyrinogen IX dehydrogenase [quinone]</fullName>
            <ecNumber evidence="5">1.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protoporphyrinogen IX dehydrogenase [menaquinone]</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Protoporphyrinogen IX dehydrogenase [ubiquinone]</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Protoporphyrinogen oxidase</fullName>
            <shortName evidence="5">PPO</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hemG</name>
        <name evidence="7" type="ORF">HMPREF0766_12962</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX; under anaerobic conditions uses menaquinone as an electron acceptor, under aerobic conditions uses ubiquinone as an electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3 a menaquinone + protoporphyrinogen IX = 3 a menaquinol + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:27409"/>
            <dbReference type="Rhea" id="RHEA-COMP:9537"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="ChEBI" id="CHEBI:16374"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.5.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3 a quinone + protoporphyrinogen IX = 3 a quinol + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:65032"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3 a ubiquinone + protoporphyrinogen IX = 3 a ubiquinol + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:63936"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="5">Binds 1 FMN non-covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HemG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993826.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12962"/>
    <dbReference type="EnsemblBacteria" id="EFK57889">
        <property type="protein sequence ID" value="EFK57889"/>
        <property type="gene ID" value="HMPREF0766_12962"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094839_0_1_10"/>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070819">
        <property type="term" value="F:menaquinone-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00853">
        <property type="entry name" value="HemG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044264">
        <property type="entry name" value="HemG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 5" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_5" evidence="6">
        <location>
            <begin position="6"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="175" mass="20046" checksum="4D5C87FB4B8FC15A" modified="2010-10-05" version="1">MSVKTVIIYSSVDGQTKKICHVLKDILVSEGHLVDQFQIQDVTKSITIYDKIVIASSIRYGKHNEHILSFIQDNNQVLNNKKTAFISVNLVARKTEKSTAGTNPYVIKFFNSITWKPQLTGVFAGRLNYKLYSFRDRHMIKLIMLITKGPVSSKTDIEYTDWNEVSKFGHKLCKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ27</accession>
    <name>D7VQ27_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_13081</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994001.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13081"/>
    <dbReference type="EnsemblBacteria" id="EFK55878">
        <property type="protein sequence ID" value="EFK55878"/>
        <property type="gene ID" value="HMPREF0766_13081"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002926_1_1_10"/>
    <dbReference type="OrthoDB" id="170130at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="5">
        <location>
            <begin position="165"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid" evidence="4">
        <location>
            <begin position="346"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="6">
        <location>
            <begin position="462"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="7">
        <location>
            <begin position="796"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK55878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="879" mass="99938" checksum="C66C97C3AC102CDC" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ86</accession>
    <name>D7VQ86_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994093.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13140"/>
    <dbReference type="EnsemblBacteria" id="EFK55937">
        <property type="protein sequence ID" value="EFK55937"/>
        <property type="gene ID" value="HMPREF0766_13140"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006553_3_0_10"/>
    <dbReference type="OrthoDB" id="336349at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="298"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="516"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK55937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1027" mass="114826" checksum="9FE1C8A8644E6666" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ93</accession>
    <name>D7VQ93_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994107.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13147"/>
    <dbReference type="EnsemblBacteria" id="EFK55944">
        <property type="protein sequence ID" value="EFK55944"/>
        <property type="gene ID" value="HMPREF0766_13147"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50340QU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1239488_0_0_10"/>
    <dbReference type="OrthoDB" id="2145998at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="27"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="223" mass="26272" checksum="0CC4B15268C44FDA" modified="2010-10-05" version="1">MKIEIDGIWYEWVPSVRDTFKVLEQDGTFVRLQVPAHADEAFVKSYIRTHRAILLKGHKSNAADTIEPIEIFGIPHFVHHQENCSQPYIKGFRIYLNTYDRQWTNKGIDSLKKSLLLQLIIQLVGHWEEQLDLLTGEILIRKLRSNWYNTDKQSCNLTFDTALTDQPADYITYIVIRALLSLQKNAKKEQEHQLDHLLPGWQEKEEALAYERTKFRDTDYDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQK1</accession>
    <name>D7VQK1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13255"/>
    <dbReference type="EnsemblBacteria" id="EFK56052">
        <property type="protein sequence ID" value="EFK56052"/>
        <property type="gene ID" value="HMPREF0766_13255"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031MRJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046825_3_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022134">
        <property type="entry name" value="DUF3667"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12412">
        <property type="entry name" value="DUF3667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="248" mass="28812" checksum="8A6D2208E34D8DA9" modified="2010-10-05" version="1">MTEKNCLNCHDEITGNYCKSCGQKSSTHRYSLKHFFEHDLVHGVWHVDKGILFTIKELFTRPGHSIRGYILGKRVGYFNFVTLILIIIAVSGIIGHYSDIKLSDLMPEQSREAAGPIERILTKYPKLVPLITIPLYSLFSFLWFRKAKFNYSEHLVLNSYKSAAELVIGLLFTTLTVFYTDKTVLFFLYYTVISISMLIYTVWIYYQFFSESGYSRRGRMIRSIMIPVSYILLSLVFGIIWGIISRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQL8</accession>
    <name>D7VQL8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994382.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13272"/>
    <dbReference type="EnsemblBacteria" id="EFK56069">
        <property type="protein sequence ID" value="EFK56069"/>
        <property type="gene ID" value="HMPREF0766_13272"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_10"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="259" mass="28156" checksum="46D0E260914C5F56" modified="2010-10-05" version="1">MNKESYFNNQVVLISGGLGDIGLATVKAFARQGARVAIGDRLSPEAAALQLARLQEVGYPCRYDQVDVQDAEAVEQWVESIAEHWGKVDIAIANAATVTLKDYQQISPAEWDQEIKVNLNGSFYLANAVARKIVQQGSAGNIVFLGSWAAHVVHQNLPAYSVSKAAIRMLCQSMALEYAPHGIRINEVAPGYVNAGLSKEVWSQHPGLADQARETVPVRALIEAEEVADQVVWICHPKNRHLTGSTILMDGGLSLSRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQS2</accession>
    <name>D7VQS2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CheR methyltransferase, SAM binding domain protein</fullName>
            <ecNumber evidence="2">2.1.1.80</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cheR</name>
        <name evidence="2" type="ORF">HMPREF0766_13326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994451.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13326"/>
    <dbReference type="EnsemblBacteria" id="EFK56123">
        <property type="protein sequence ID" value="EFK56123"/>
        <property type="gene ID" value="HMPREF0766_13326"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025854_1_0_10"/>
    <dbReference type="OrthoDB" id="1378151at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008983">
        <property type="term" value="F:protein-glutamate O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="274" mass="32144" checksum="B9C98967A7F155C3" modified="2010-10-05" version="1">MLEPNIIKNDELEMLLADVSALYGYDFTQYSRASLKRRINRICLIDKFTSFAELRYKVLNHPEYLQRFIEEITVNVTEMFRDPSFYKALRENVFPQLGTYPFIRIWLAGCSTGEEVYSMAIMLKEANLYHRSLLYATDINPGVLEKARKGIFPISQMKQYSENYILSGGKSDFSTYYTANYDVVKFNEDLKEKMIFSTHNLVSDSSFNEFQLVICRNVLIYFDKELQNKVFRLFDDSLDSLGFLALGSKETLRFSALESRYKQLDAEKIWRKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQV4</accession>
    <name>D7VQV4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994491.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13358"/>
    <dbReference type="EnsemblBacteria" id="EFK56155">
        <property type="protein sequence ID" value="EFK56155"/>
        <property type="gene ID" value="HMPREF0766_13358"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_466072_0_0_10"/>
    <dbReference type="OrthoDB" id="692538at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107252" evidence="1">
        <location>
            <begin position="23"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="588" mass="64294" checksum="F2F0DEE84B8F18BC" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQZ1</accession>
    <name>D7VQZ1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994535.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13395"/>
    <dbReference type="EnsemblBacteria" id="EFK56192">
        <property type="protein sequence ID" value="EFK56192"/>
        <property type="gene ID" value="HMPREF0766_13395"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7KY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124273_0_0_10"/>
    <dbReference type="OrthoDB" id="1197155at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025352">
        <property type="entry name" value="DUF4256"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14066">
        <property type="entry name" value="DUF4256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="189" mass="21943" checksum="E33CDB02C4F78604" modified="2010-10-05" version="1">MKKSKEPELSIAQREHLFEVLKTRFENHMHRHPDLHWDKVLTRLDAAADKLRSLYEMEETGGEPDVVSYDKKSGLCIFFDCSPETPKGCRSLSYDREGQDSRKEHRPENNAIDLAMEMGIELLSEEQYRYLQQLGSFDNKTSSWLRTPEPIRKLGGAIFGDYRYGQVFIYHNGAASYYAVRGFRGWIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR31</accession>
    <name>D7VR31_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sigma factor regulatory protein, FecR/PupR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994597.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13435"/>
    <dbReference type="EnsemblBacteria" id="EFK56232">
        <property type="protein sequence ID" value="EFK56232"/>
        <property type="gene ID" value="HMPREF0766_13435"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050192_2_2_10"/>
    <dbReference type="OrthoDB" id="1381035at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="59"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="266" mass="30139" checksum="5027907F72DD57BF" modified="2010-10-05" version="1">MEFDKEKAWNNIQGRIHKKQQKDKKTNRLLSTLIAVLIISGSLSYFLLKHSSDAPQLITVTTSAHEIKTIVLTDSSRLILNGNTSVSYPSQFETSIREVHLLSGEASFAISHDASRPFHVWYKESKIEVLGTYFNINTYSPTVYVTLKEGLISFHHGTFQQMLHPGQRLQFSPSDRKVQVREVNPEQEFSWQSGKWVFQEIPLETALSRIALYYGKTFKQSNPAAAYPALTLSLSKDQLQLPALLDAIAKVSHSRITLEANQLILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR38</accession>
    <name>D7VR38_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994605.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13442"/>
    <dbReference type="EnsemblBacteria" id="EFK56239">
        <property type="protein sequence ID" value="EFK56239"/>
        <property type="gene ID" value="HMPREF0766_13442"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025928_2_0_10"/>
    <dbReference type="OrthoDB" id="251905at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024302">
        <property type="entry name" value="SusD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12741">
        <property type="entry name" value="SusD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107182" evidence="1">
        <location>
            <begin position="30"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="553" mass="60890" checksum="41FC0FB2D53D9C74" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR41</accession>
    <name>D7VR41_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F5/8 type C domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13445"/>
    <dbReference type="EnsemblBacteria" id="EFK56242">
        <property type="protein sequence ID" value="EFK56242"/>
        <property type="gene ID" value="HMPREF0766_13445"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50348B9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_578398_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013728">
        <property type="entry name" value="DUF1735"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08522">
        <property type="entry name" value="DUF1735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="303"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="459" mass="49798" checksum="55CC5828B230F820" modified="2010-10-05" version="1">MTACKKELDNPSELFLYVPSGSLSYNSSTVSYAIARGKIFEGTGIAFPVLLTRAFGQDVQVTATIDTSLLAEYDRVNKTKSPVIPAGAFLLKNNGQIRIPAGQERSADSVQLSFGEGAANLDFTKQYVVPVRLISTNANVPLSTNRQVMYMRITFSRIMTQLNDLPANRLIPITIIRTPNGDIINGNLNISAGVNTAFSQDLSVALQARPDLLTGYNQTNQTQYLAFPANSFTFKPASVSINSASLKATTPISLVLNNTTAFEPGKSYLLPAGIVDEGPVPPHDTQGLAYFKVDVQIQNINPDNPTPSGTRGDRSVWTAIASSTDATFTTGNPGMVFDNDAATGWHSELTFGTQPAVLFTIDMHNQKSIRGFTFTPRYWNYFGSDFISAVTEMQLASSNDGINWTSQGSYAGSMPKGTATNPELRNVSFYTPVQARYFRFTITGYGDYAAGFGELNAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR64</accession>
    <name>D7VR64_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13468"/>
    <dbReference type="EnsemblBacteria" id="EFK56265">
        <property type="protein sequence ID" value="EFK56265"/>
        <property type="gene ID" value="HMPREF0766_13468"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3030107_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="55" mass="6772" checksum="9A11551AF528A690" modified="2010-10-05" version="1">MEYVLHVLENERKQLRKILYEEDLMRRNMKKATFAMKNIRDLEIAIKLLKHKSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR95</accession>
    <name>D7VR95_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994679.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13499"/>
    <dbReference type="EnsemblBacteria" id="EFK56296">
        <property type="protein sequence ID" value="EFK56296"/>
        <property type="gene ID" value="HMPREF0766_13499"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089264_0_1_10"/>
    <dbReference type="OrthoDB" id="1776310at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019619">
        <property type="entry name" value="DUF2490"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10677">
        <property type="entry name" value="DUF2490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107189" evidence="1">
        <location>
            <begin position="23"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="226" mass="26408" checksum="09C71FC2C2D8CE5E" modified="2010-10-05" version="1">MKTIFTAVSVLLLMFSATPSVAQSASSEDLGAWYILMGDEKIAKRWVLSYDFQYRNHNIMGDLDQLLLRSGVGYDLSENNNNLLLGYAYVLQDIDGLIPEQISEHRIYQQFLTKQKFGRVAISHRYRFEQRFMRKRTDLRMRYFLSVNVPLSTQEMKPRTVYFSAYNEVFINMKKEAFDQNRLYGSVGYVVSPKIRVEAGLLNQHFGERKRNLLQVRMLTSNIFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRA1</accession>
    <name>D7VRA1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Competence protein ComEA helix-hairpin-helix repeat region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994687.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13505"/>
    <dbReference type="EnsemblBacteria" id="EFK56302">
        <property type="protein sequence ID" value="EFK56302"/>
        <property type="gene ID" value="HMPREF0766_13505"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077104_0_1_10"/>
    <dbReference type="OrthoDB" id="1948240at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="309" mass="35748" checksum="6B5238799F31C338" modified="2010-10-05" version="1">MNKLFYFFRLSRAEQKGFFVLLVLIGLMTFSPIVWNLIHTSPSVSYQLHIFEDDKTVQSYTEIEKQESLDPGSTYYSSKATPLNAVTYFEFDPNQLKAEGWEKLGFKAYQIRMILNYTAKGGKFYKKEDLRKIYAIKEADYQRIEAYIRIPRTPSADHNSTAETSAPYPKMYQNTVKTAVIDINTADTTAWMSLKGIGPSFARRIVRFRDALGGFYSIQQINEVYGMDAERYKTIESSLGVVSTDIRQLELNTLTAAELARHPYINYKQATAIANYRREHGNYKNINDLKAVLLLDEEFLRKLEPYLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRA5</accession>
    <name>D7VRA5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994691.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13509"/>
    <dbReference type="EnsemblBacteria" id="EFK56306">
        <property type="protein sequence ID" value="EFK56306"/>
        <property type="gene ID" value="HMPREF0766_13509"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015931_2_0_10"/>
    <dbReference type="OrthoDB" id="567477at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043741">
        <property type="entry name" value="DUF5686"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18939">
        <property type="entry name" value="DUF5686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="866" mass="100134" checksum="16247C61CD095FD7" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRF0</accession>
    <name>D7VRF0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-70 region 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994742.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13554"/>
    <dbReference type="EnsemblBacteria" id="EFK56351">
        <property type="protein sequence ID" value="EFK56351"/>
        <property type="gene ID" value="HMPREF0766_13554"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_2_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="26"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="120"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="190" mass="21913" checksum="F05B886A70646CA8" modified="2010-10-05" version="1">MNLFFSRDNKLVKGCKANKRQAQEVLYKLYYEDMLRLCFRYLRSDDLALEALNSGFLKIFQNINTFDPQKGDLGAWIRTIMVRSCIDLSRKEARFNYSAIQDVTEEVYIEPSVLDKLFAEDLLKLIRLLPVATQIVFNLSVIDGYSHQEIAEQLGISEGTSRWHLSEAKKQLRTMLKNATIDNPLKNPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRG0</accession>
    <name>D7VRG0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13564"/>
    <dbReference type="EnsemblBacteria" id="EFK56361">
        <property type="protein sequence ID" value="EFK56361"/>
        <property type="gene ID" value="HMPREF0766_13564"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3222233_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="44" mass="5576" checksum="478843CACCB4C279" modified="2010-10-05" version="1">MFIILIYFNRNAYRNKLYLKFAQKYKISWPNMTFKPRQPNLEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRH2</accession>
    <name>D7VRH2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994768.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56373">
        <property type="protein sequence ID" value="EFK56373"/>
        <property type="gene ID" value="HMPREF0766_13576"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2920434_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="61" mass="6587" checksum="7367DED94639873A" modified="2010-10-05" version="1">MMNKNNKTDYISPAITSNIIELEQGIAASSARLVPGGDGTNSANPKVEDWTTDTESRDLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRK4</accession>
    <name>D7VRK4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TonB-dependent siderophore receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0766_13608</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13608"/>
    <dbReference type="EnsemblBacteria" id="EFK56405">
        <property type="protein sequence ID" value="EFK56405"/>
        <property type="gene ID" value="HMPREF0766_13608"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_9_4_10"/>
    <dbReference type="OrthoDB" id="169533at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107599" evidence="7">
        <location>
            <begin position="26"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="9">
        <location>
            <begin position="62"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="8">
        <location>
            <begin position="257"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK56405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="713" mass="80191" checksum="9E0AFA2FAF4F0A83" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRL2</accession>
    <name>D7VRL2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56413">
        <property type="protein sequence ID" value="EFK56413"/>
        <property type="gene ID" value="HMPREF0766_13616"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3276838_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="41" mass="4770" checksum="F84B4925792712C2" modified="2010-10-05" version="1">MKKIPFRKNKNKHSSLSKLLYKNTTEDKLRIAKQSALLIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRN3</accession>
    <name>D7VRN3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994884.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13637"/>
    <dbReference type="EnsemblBacteria" id="EFK56434">
        <property type="protein sequence ID" value="EFK56434"/>
        <property type="gene ID" value="HMPREF0766_13637"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032U9N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122870_0_0_10"/>
    <dbReference type="OrthoDB" id="1915365at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="185" mass="20376" checksum="B3320D09312C28C6" modified="2010-10-05" version="1">MRYHRLLRFFLIGLLFIIQLLFLLAIFRENMQSPWVSVFIIAISILILISYIRVPIHHDKHLYDHILVSIGVPVGAISCYYLHTHFHLGTVFSAGIIGTAGSFVPLLNKRSSYLQQLPAAIYCGAFVGMSSEGIANGFTFILAASICTAVLLVVSKSLFSGIGGKLGTLAFLGVSITYLIIFLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRR1</accession>
    <name>D7VRR1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Efflux transporter, outer membrane factor lipoprotein, NodT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994954.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13665"/>
    <dbReference type="EnsemblBacteria" id="EFK56462">
        <property type="protein sequence ID" value="EFK56462"/>
        <property type="gene ID" value="HMPREF0766_13665"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_13_3_10"/>
    <dbReference type="OrthoDB" id="1619477at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="474" mass="52122" checksum="3B1D94F0DF02A538" modified="2010-10-05" version="1">MNIKFYSVTIFLITLILSGCKTERLATHVPVTLPDNYRDSDALKTDTNTIGSIPWREFFKDAMLQQLIDSAIRQNMDMQLAVKNIEASRLLLSQAKAANLPNLQLRVNATSTNPSNNSMNGLSLNQFLGANHVEDYTAALSLSWEADIWGKIKNQKAAALASYLQTEEARKVVQTQLVSQVAQGYYQLLMLYQLQDIAKKNLRLSDSTLRIVQYQYEVGDISSLAVEQVAAQRLAAAALIPDFEQQVQIQENAISVLSGQLPHAITTTATLNTITLPEHLQVGIPAAMLSRRPDVKSAELAIAAAQANQQTAKASMYPSLVISADAGVNAFKSSNWFNLPASLFGVVAGSITQPILQRKQLRTQYEVSRVEQEKSVIRFKQSVITAVGEVSDAMISIRKLKEKEVIASDRTNRLRNAIGHADLLFETGMATYLEVITAQSNVLQSELELAQLKKAELAAIVDLYRALGGGWTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRV6</accession>
    <name>D7VRV6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RelA/SpoT family protein</fullName>
            <ecNumber evidence="3">2.7.6.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">relA</name>
        <name evidence="3" type="ORF">HMPREF0766_13710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the relA/spoT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995073.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13710"/>
    <dbReference type="EnsemblBacteria" id="EFK56507">
        <property type="protein sequence ID" value="EFK56507"/>
        <property type="gene ID" value="HMPREF0766_13710"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012300_3_2_10"/>
    <dbReference type="OrthoDB" id="204079at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008728">
        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TGS" evidence="2">
        <location>
            <begin position="402"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="736" mass="83650" checksum="48B627AE2BB26019" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS08</accession>
    <name>D7VS08_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995205.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13762"/>
    <dbReference type="EnsemblBacteria" id="EFK56559">
        <property type="protein sequence ID" value="EFK56559"/>
        <property type="gene ID" value="HMPREF0766_13762"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZHGZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2650656_0_0_10"/>
    <dbReference type="OrthoDB" id="2083829at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="78" mass="9136" checksum="62FDC4D8E06C8534" modified="2010-10-05" version="1">MPKIRCVCDYIINLSEIPSANQYLMISDVSFEKYFDEEVNAEDLYSKMIIVAHCSNCGRLHVFYDGFDKDQVIYRVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS55</accession>
    <name>D7VS55_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995316.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13809"/>
    <dbReference type="EnsemblBacteria" id="EFK56606">
        <property type="protein sequence ID" value="EFK56606"/>
        <property type="gene ID" value="HMPREF0766_13809"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZX07">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1353905_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="202" mass="24030" checksum="310EB63865D3AE00" modified="2010-10-05" version="1">MNEFREKEINNIIRLRRVVMTLLLLVNFSIIFFFCYNFHVVYTERKLYHINFLSYILPTILYLQAVLAVPFGLLLFFTYRRTATFITILRQLDSDSLLLYHQYVQVIGRFWAGIAPYIFQTRHIIIPTLLSQKNIPYTDIMDVSFSRSRPYKAPTTYSMNIRTFENKKHSVTFYQYAQAQFAMHTLMNKQPGIPVVNNMNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSC1</accession>
    <name>D7VSC1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995478.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13875"/>
    <dbReference type="EnsemblBacteria" id="EFK56672">
        <property type="protein sequence ID" value="EFK56672"/>
        <property type="gene ID" value="HMPREF0766_13875"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5034BUV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2318664_0_0_10"/>
    <dbReference type="OrthoDB" id="2102602at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="99" mass="11191" checksum="59C8A03CBD76C44D" modified="2010-10-05" version="1">MQSTEEINTSRSLSAKLLALLYILVLIYLGLILPSENDQFFIPVIYLVVIAVLQFSFVVYYRLRFKSAAVIFLILVVVLLSLFAGFLYYISGLAAAYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSF2</accession>
    <name>D7VSF2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995545.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13906"/>
    <dbReference type="EnsemblBacteria" id="EFK56703">
        <property type="protein sequence ID" value="EFK56703"/>
        <property type="gene ID" value="HMPREF0766_13906"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1804958_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="143" mass="15885" checksum="95FECCB712838A87" modified="2010-10-05" version="1">MPKSMYLVALLSAGISFSGISDLYAQEKNKKHSIENFNASNVMELLNILPHESNPLNAEAIIIQNGLSNTTTVYLENDVLISHQQGNGNNIYYQDSQYSNPARMYISIFGENNTIEIVGSNSISDRMSVEISGHNKTLQMLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSJ8</accession>
    <name>D7VSJ8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995608.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13952"/>
    <dbReference type="EnsemblBacteria" id="EFK56749">
        <property type="protein sequence ID" value="EFK56749"/>
        <property type="gene ID" value="HMPREF0766_13952"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_2_4_10"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="280" mass="32293" checksum="35A829FDB4CFDEEF" modified="2010-10-05" version="1">MKRILFPTDFSEAANNAFVYALQLAKSIDASLYILHVYELPIYSSMYAGQLDYVQQIYQSIELAQFDNYKDNVPQLHEIAKKYNLEDIEMYFVFEKGLFLDSIKRVIKRDQIDMIVMGTTGLNSANTTLIGSNTVNLIRSVSQPVFSIPRLAKFDGIKAIGFTTLFREADKKPLAEILKLADYFDAKVEVLHIKTKENEDIESQAEAWKQQFNNSRLTFSILPATSVEERVLEFIMEHKIDFLAIVKRNRNFFDRLFTSSMSQKLAYHSTIPILVIREEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSY2</accession>
    <name>D7VSY2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995877.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14086"/>
    <dbReference type="EnsemblBacteria" id="EFK56883">
        <property type="protein sequence ID" value="EFK56883"/>
        <property type="gene ID" value="HMPREF0766_14086"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8GA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_526519_0_0_10"/>
    <dbReference type="OrthoDB" id="1081030at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107548" evidence="1">
        <location>
            <begin position="22"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="520" mass="59585" checksum="410E6EA23EC3232F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSZ6</accession>
    <name>D7VSZ6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YDG/SRA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995906.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14100"/>
    <dbReference type="EnsemblBacteria" id="EFK56897">
        <property type="protein sequence ID" value="EFK56897"/>
        <property type="gene ID" value="HMPREF0766_14100"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3440">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061333_0_0_10"/>
    <dbReference type="OrthoDB" id="1629654at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="PTHR14140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YDG" evidence="1">
        <location>
            <begin position="7"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="288" mass="32245" checksum="49407F6C7A676C5E" modified="2010-10-05" version="1">MTAYIFGNLPNIEEGNEFENRQELRKAGIHLALQSGIDGNSKVGSPSIVLSGGYEDDEDFGDIIIYTGHGGNDIKTKKQISDQSWDSPGNKALLISELHGLPVRVTRGYKHKSSLSPIKGYKYGGLYQVIEHFEKTGKNGFLICKYKLEKISNLNTLAKEDQDEYHKAPSRKAVNILRIVRDTKLSIDIKNLYDYSCQICNITIAVHNVKYAEGAHIKPLGTPHNGLDLLNNLLCLCPNHHVMLDKGMIAINSDLTLLGIKGNIKLHKDHILDDTNCQYHKEHIFINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT31</accession>
    <name>D7VT31_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conjugative transposon TraM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">traM</name>
        <name evidence="3" type="ORF">HMPREF0766_14135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996003.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14135"/>
    <dbReference type="EnsemblBacteria" id="EFK56932">
        <property type="protein sequence ID" value="EFK56932"/>
        <property type="gene ID" value="HMPREF0766_14135"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7X2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037847_1_0_10"/>
    <dbReference type="OrthoDB" id="1581328at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022187">
        <property type="entry name" value="Conjug_transposon_TraM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12508">
        <property type="entry name" value="Transposon_TraM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03779">
        <property type="entry name" value="Bac_Flav_CT_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="446" mass="48878" checksum="2BB41D0FD9EF6D54" modified="2010-10-05" version="1">MKENEKRVSILVEEGDQSKASNLLDDKKNSKDRLKKPLIFGLMAIVFLGCMYLIFKPSKDKKEVENIGLNDAVPQATGAGMPDSKGKAYEQEMLEQKDQEKRNALTTLSDYWNEDSSSANAKSEEDFVEEEESNGYGSGRNSGRYGNPALNSYRNTQSTLGSFYNNDNAETMELRRQLDELKEKLADKDVPKATTVDDQLALMEKSYQMAAKYLPQGNSSNGEATPTNGTASGASTASQKEHFVSFTPTRKNTVSALYREPTDSEFLNDLNQTKNRGFYTAGSTEQVVQPKNSIKACVHDAQTVVGETGVRLRLLEPAKTPNRTIPKGTIVTANAKFQGGRLQLKVTSVELEGNIIPVDITIYDLDGQQGLYVPYSPEMNALTEMAGNMSQTGGTSVMLTQNAGQQVAADLSRGIVQGISGYFAKKVRTPKVTLKAGHQVFLVSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTC7</accession>
    <name>D7VTC7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="11">ATP-PRT</shortName>
            <shortName evidence="11">ATP-PRTase</shortName>
            <ecNumber evidence="4 11">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">hisG</name>
        <name evidence="14" type="ORF">HMPREF0766_14231</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Feedback inhibited by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ATP phosphoribosyltransferase family. Long subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="4 11"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996247.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14231"/>
    <dbReference type="EnsemblBacteria" id="EFK57028">
        <property type="protein sequence ID" value="EFK57028"/>
        <property type="gene ID" value="HMPREF0766_14231"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038115_1_0_10"/>
    <dbReference type="OrthoDB" id="1419568at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP_PRibTrfase_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="12">
        <location>
            <begin position="51"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="HisG_C" evidence="13">
        <location>
            <begin position="208"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFK57028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="283" mass="30888" checksum="0A9ADEEA4E5B04FD" modified="2010-10-05" version="1">MKNLKIAIQKSGRLNEKSVQLLKNCGLDFENYKSSLITSVANFPLEILFLRDDDIPGYVEQGIADLGIVGENVIDESEAQVSYVKRLGFGKCTLKLAVPKDSKIEDLKDLNGKAIATSYPVILKNFLDEYQITADIRLISGSVEISPGLGLSDAICDIVSTGGTLKSNGLKPFADVRRSEAILIGRKGLEDNLILTELVQRIESVLLAKETKYVVLNVEKKNLPAITSLLHGVKSPTVVPLAEEGWVAVHTVISEDDFWEKINTLKSAGAQGIVVMPIEKIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTE5</accession>
    <name>D7VTE5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996289.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14249"/>
    <dbReference type="EnsemblBacteria" id="EFK57046">
        <property type="protein sequence ID" value="EFK57046"/>
        <property type="gene ID" value="HMPREF0766_14249"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1804959_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107917" evidence="1">
        <location>
            <begin position="20"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="143" mass="16417" checksum="9584CF7C6694C82F" modified="2010-10-05" version="1">MHKLLLLFTLLLGYTCSFAQENDEKLIKSFLKDIYETETITDAFLDHYFTQGIDSAKKDKIINNLTNLKSTIVQTIDKEKLPSLEVKSPSLKSENPNANTRPFIIPLNADYSLGFWVGDNKIKTILWLKPSDFSTTIYYDVNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTP9</accession>
    <name>D7VTP9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14369"/>
    <dbReference type="EnsemblBacteria" id="EFK55808">
        <property type="protein sequence ID" value="EFK55808"/>
        <property type="gene ID" value="HMPREF0766_14369"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2048246_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107390" evidence="1">
        <location>
            <begin position="21"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="149" mass="16746" checksum="A08BB72525B1772A" modified="2010-10-05" version="1">MKNYYIILILALVTTFSSCSKNEASPPHGMIDIATTLTNGDKVITGDGYIFCDIAVIPIKDFPKEINKNTVYHIFSDMPKYVKYATKDFTKAVPSGDYTILVQVIGASDNYKSLIGTYSYKRTLISEGNPVKDSAKFDLNNREDFHPWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTR9</accession>
    <name>D7VTR9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14389"/>
    <dbReference type="EnsemblBacteria" id="EFK55698">
        <property type="protein sequence ID" value="EFK55698"/>
        <property type="gene ID" value="HMPREF0766_14389"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_948409_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="294" mass="34493" checksum="5796EDC6B186D6C1" modified="2010-10-05" version="1" fragment="single">MSTSTKYTYRKNIGLLIAFVVFVTILYVVSVFFARTMISNFVDSEFANRKVEVYDKSLVPFNDFFQNRIPEISYYQGFLDTNEARGMIDNILRKYPFVRETMFYDIAITNDEEEGYQIKYNNLLIQSRSVFSYSLNENHHLISKRMEDNNLKNYSDDFNNMTVKLVSFLDRVNDSTKLTDNLIFKIFYDMTPGKIAYMNIPRIGDLVSYRELLRGAIKQPVTYDQDLFVFYIDPRKIKITNVYPNLYEHIEIVPLVSVNLTGEKPYLYTEVSLPGALSDYKITFSTSESFIKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTU6</accession>
    <name>D7VTU6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">tRNA methylthiotransferase YqeV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yqeV</name>
        <name evidence="10" type="ORF">HMPREF0766_14416</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002246.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14416"/>
    <dbReference type="EnsemblBacteria" id="EFK55725">
        <property type="protein sequence ID" value="EFK55725"/>
        <property type="gene ID" value="HMPREF0766_14416"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_1_0_10"/>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006467">
        <property type="entry name" value="MiaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01579">
        <property type="entry name" value="MiaB-like-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="145"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK55725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="447" mass="50590" checksum="7E8E952E8F0581D6" modified="2010-10-05" version="1">MYFCKIIMNKKVAFYTLGCKLNFSETSSIGRIFKDAGYETTAFNSQADVYVINTCSVTDHADKKCRKVVKEALKYSPNAYITIVGCYAQLKPQEIANIPGVDMVLGAAEKFNIIEHINDLTKQEKTIVHNAPIDETNQFVSAYSIGDRTRTFLKVQDGCDYSCTFCTIPLARGASRSGKIEDIVRQAEEIAASGVKEIVLTGVNIGDFGVRDGERQDRFLDLVKALDEVEGIDRIRISSIEPNLLANDIIEFVAQSKRFVPHFHMPLQSGNNKILGMMRRRYKRELYAERVAKIKSLMPDCCIGVDVIVGFPGETREDFLDTYNFLNEMDISYLHVFTYSERENTIAAQMEGAVPGAQRSDRSKMLHILSEKKRRAFYENQLSKIGDVLFESDEKEGFMHGFSKNYVKVRTAYDPLLVNEVIQVRFTSITETGEVEIEELPEVFIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTU7</accession>
    <name>D7VTU7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 5">Thymidylate synthase</fullName>
            <shortName evidence="5">TS</shortName>
            <shortName evidence="5">TSase</shortName>
            <ecNumber evidence="1 5">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">thyA</name>
        <name evidence="8" type="ORF">HMPREF0766_14417</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="1 5"/>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002248.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14417"/>
    <dbReference type="EnsemblBacteria" id="EFK55726">
        <property type="protein sequence ID" value="EFK55726"/>
        <property type="gene ID" value="HMPREF0766_14417"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021669_0_0_10"/>
    <dbReference type="OrthoDB" id="1212177at2"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="PTHR11548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="SSF55831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylat_synt" evidence="7">
        <location>
            <begin position="2"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="126"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="175"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="216"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK55726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="273" mass="31246" checksum="6C1144AF0CF694E2" modified="2010-10-05" version="1">MKQYLDLLKHVYTNGVTKTDRTGTGTKSVFGYQMRFNLKEGFPLVTTKKLHLRSIIHELIWFLKGETNIQYLKENGVSIWDEWADEQGNLGPVYGSQWRSWPTPAGEHIDQIAQVIKQLKNTPDSRRIIVSAWNVAEIEHMALPPCHAFFQFYVAPAQPEAGILKPQLSCQLYQRSADIFLGVPFNIASYALLTMMVAQVCDMEPAEFIHTLGDAHIYSNHFEQTELQLSRDPKPLPKMIINPDVRDIFDFKFGDFELVDYESHPHIKAPVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTV4</accession>
    <name>D7VTV4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioester hydrolase, YbgC/YbaW family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ybgC</name>
        <name evidence="3" type="ORF">HMPREF0766_14424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002262.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14424"/>
    <dbReference type="EnsemblBacteria" id="EFK55733">
        <property type="protein sequence ID" value="EFK55733"/>
        <property type="gene ID" value="HMPREF0766_14424"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101141_3_2_10"/>
    <dbReference type="OrthoDB" id="1786865at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006684">
        <property type="entry name" value="YbgC/YbaW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003230">
        <property type="entry name" value="YbgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00051">
        <property type="entry name" value="TIGR00051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="18"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK55733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="136" mass="15875" checksum="FA62E6391DCDD4A1" modified="2010-10-05" version="1">MFVFENQLRVRYAETDQMGYMYYGNYAAFYEVARTEMLRSTGISYKELEDMGVMLPVLELNCRFIKPARYDELITIKTTIRSKPGIRLKFEHELYNEAGELINTGSTQLVFVDIKKNKPCMPPAIFQHKMAAYFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGC2</accession>
    <name>D7VGC2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001923.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10041"/>
    <dbReference type="EnsemblBacteria" id="EFK60097">
        <property type="protein sequence ID" value="EFK60097"/>
        <property type="gene ID" value="HMPREF0766_10041"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_18_1_10"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025870">
        <property type="entry name" value="Glyoxalase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12681">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="131" mass="14504" checksum="5A80EEA286D5EED3" modified="2010-10-05" version="1">MVKLGYTILYVSDVTKSIQFYERAFGLERKFITAHNDYAELLTGETTLSFASKELAASNLPEGFTEANLQMKPFAVEIGFVTEQIDEVLETAISAGATVVSPLTTKPWGQQVVYLRDTDGFLIELCTTVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGF2</accession>
    <name>D7VGF2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001999.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10071"/>
    <dbReference type="EnsemblBacteria" id="EFK60127">
        <property type="protein sequence ID" value="EFK60127"/>
        <property type="gene ID" value="HMPREF0766_10071"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032Z3E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_198869_0_0_10"/>
    <dbReference type="OrthoDB" id="2056546at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK60127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="67" mass="8062" checksum="493415E5B691510E" modified="2010-10-05" version="1">MRNNMHRVCIYPKDIQLITGKSYRQSARLMQKIKKELHKPDKEFLTIDEFCTYTGIRYEQVSHLIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGH4</accession>
    <name>D7VGH4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SymE_toxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002043.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10093"/>
    <dbReference type="EnsemblBacteria" id="EFK60149">
        <property type="protein sequence ID" value="EFK60149"/>
        <property type="gene ID" value="HMPREF0766_10093"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2439252_0_0_10"/>
    <dbReference type="OrthoDB" id="1966690at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014944">
        <property type="entry name" value="Toxin_SymE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08845">
        <property type="entry name" value="SymE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SymE_toxin" evidence="1">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="90" mass="10596" checksum="6C376EE688233AD4" modified="2010-10-05" version="1">MNIKKASRTPYRNKGKLLETRRITVCRKVLEKRNDYGRYNPVITLTGKWLWESGFKGGDKLALKVYEKRIVIEIEMSGEEFYKDVYDGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGH8</accession>
    <name>D7VGH8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002051.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10097"/>
    <dbReference type="EnsemblBacteria" id="EFK60153">
        <property type="protein sequence ID" value="EFK60153"/>
        <property type="gene ID" value="HMPREF0766_10097"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032YCE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133781_4_0_10"/>
    <dbReference type="OrthoDB" id="2076478at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="36"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="97" mass="11315" checksum="452BBA7E125011F1" modified="2010-10-05" version="1">MAVEIITREDLNEFRTRLLDDLRELIQGKPNQNKKWLKSAEVRKLLNISSGTLQNLRINGTLSYTRVGGTMYYDHQDIDKLLNDNKVIAFRNKKPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGR7</accession>
    <name>D7VGR7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">lpdA</name>
        <name evidence="16" type="ORF">HMPREF0766_10186</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996816.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10186"/>
    <dbReference type="EnsemblBacteria" id="EFK59269">
        <property type="protein sequence ID" value="EFK59269"/>
        <property type="gene ID" value="HMPREF0766_10186"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_1_10"/>
    <dbReference type="OrthoDB" id="267896at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="3"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="348"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="143"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="180"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="320"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="41"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFK59269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="468" mass="49697" checksum="96D07308D94854B2" modified="2010-10-05" version="1">MQYDVIVIGSGPGGYVAAIRCAQLGLKTAVIEKYSTFGGTCLNVGCIPSKALLDSSEHYHNAAHSFEDHGISLSNLKVDIKKMMARKDDVIAQNTAGITYLFKKNKIDSFQGVGSFVDKNTVLVTKEDGKTEQLTTKNVIIATGSKPTALPFLPVDKKRIITSTEALSLTEIPKNLIVIGGGVIGLELGSVYARLGAKVTVVEFAKSIISTMDGGLGKELQRVLKKSLGMEFLLGHKVTGASVKGKKVTVTAEDPKGQEISLEGDYCIVSVGRVAYTAGLGLENIGIQTEERGNKIPVNDHLETTVPGIYAIGDVIKGAMLAHKAEDEGIAVAERIAGQKPHIDYNLIPGVVYTWPEVASVGQTEEQLKEAGKKYKSGSFSFKASGRAKASGDTDGFIKVLADAETDEVLGIHMIGPRAADMIAEAVVAMEYRASAEDIGRICHAHPTFTEALKEAALAATANRAIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGU3</accession>
    <name>D7VGU3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996888.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10212"/>
    <dbReference type="EnsemblBacteria" id="EFK59295">
        <property type="protein sequence ID" value="EFK59295"/>
        <property type="gene ID" value="HMPREF0766_10212"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_15_3_10"/>
    <dbReference type="OrthoDB" id="1515911at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="10"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="146"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="303" mass="33772" checksum="3CB49D25A13EAE51" modified="2010-10-05" version="1">MPSIKINRNILVLHVTVLIWGLTGILGGLISVSAIHLVWYRVGIAAIALAVYFVFKRQSIVVSKRDFLKFFMTGAVVGLHWVLFFYSIKVSTVSVTLVTLSSVTLYTAIFEPMLYKRKIAALDIVIGLIIILGIYTIFQFETRYLAGIISGLACAFCASVFSILNGKMVKSSSPTIITFYEMLGAFFWISVFMLFSGDFNASMQLSQQDLWYLLLLGVVCTAVAYVMGVAVMKELTAFTVALTTNLEPVYGIILAVLIFGHKETMSLGFYVGALIVLTAVFIYPYVKTRMENRQKDLIIRKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH22</accession>
    <name>D7VH22_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome C biogenesis protein transmembrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dsbD</name>
        <name evidence="8" type="ORF">HMPREF0766_10291</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997102.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10291"/>
    <dbReference type="EnsemblBacteria" id="EFK59374">
        <property type="protein sequence ID" value="EFK59374"/>
        <property type="gene ID" value="HMPREF0766_10291"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015841_0_0_10"/>
    <dbReference type="OrthoDB" id="1055204at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="363"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="546" mass="59779" checksum="A717C0A3C65DDD1C" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH47</accession>
    <name>D7VH47_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative GAF domain-containing protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997155.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10316"/>
    <dbReference type="EnsemblBacteria" id="EFK59399">
        <property type="protein sequence ID" value="EFK59399"/>
        <property type="gene ID" value="HMPREF0766_10316"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1956">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077738_2_0_10"/>
    <dbReference type="OrthoDB" id="1739746at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="43"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="157" mass="16958" checksum="6ABE71AB511CC732" modified="2010-10-05" version="1">MAEDLNILTGNKAEQYKGLIPQIEALIRGESNLIANLANISAALKEQFGFFWVGFYLVEGEELVLGPFQGPVACTRIKKGKGVCGAAWADEQTLIVPDVDAFPGHIACSSLSKSEIVIPLRADGRIIAVLDVDSDSLNSFDQEDAVYLEQILSFITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHA6</accession>
    <name>D7VHA6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase, class V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997279.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10375"/>
    <dbReference type="EnsemblBacteria" id="EFK59458">
        <property type="protein sequence ID" value="EFK59458"/>
        <property type="gene ID" value="HMPREF0766_10375"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_1_10"/>
    <dbReference type="OrthoDB" id="1474443at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="29"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="362" mass="41523" checksum="A0FC8F127686DAB9" modified="2010-10-05" version="1">MSQQYKSYFDIPENISYLTTPGSGLISKEIKKWRSRYDVDFHMTDTVLREQQGAFIQQVKQTIADFAHTAAQNIYCTPNFSHGFNVILNGLPADVRILLLNEDYPSVNFPVISRGFDHTFVNIDENMEQNILEAIRHYKPDVFICSIVQYISGIKIDLSFIQELKATHPDLLIIGDGTQYLGTESFDFETSGFDGIGTSGYKWLLSGFGNGFFILNDTLKSKLYQTAQQQKPVFEKMWEGKSILQLYFEPGHVDTLAQGTLQKSLQFFDQLGIQNTAAYTSRLSEHAREEFEKRNLLTDIVKRRNNHSTIFNLQIDPNHFTTLMDNGIKCFPRGTGIRIGFHLYNDTNDLERLLQVIDKLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHB9</accession>
    <name>D7VHB9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997306.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10388"/>
    <dbReference type="EnsemblBacteria" id="EFK59471">
        <property type="protein sequence ID" value="EFK59471"/>
        <property type="gene ID" value="HMPREF0766_10388"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046965_0_0_10"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="65"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="477" mass="53006" checksum="BE09A5A6E57FD830" modified="2010-10-05" version="1">MRTDRRSFLKLSGLAGVGLLSGCSTGTNQTTEADSKLGHILKEAEKEYSSGFNMSGYAAPRLEVVNIGFIGVGNRGSAAVERMSYIEGVSIKGICDVRAEKANEAKARIKAGNHEAQLYTGSDEAWKKMCQREDISLVYIATHWATHAEMAVYAMEQGKHVALEIPSATSVEDCWKLVMTSEKTKQHCVILENCCYDFFELLTLNLARQGFFGDIVHCEGAYIHDILDSFFDENKRYDFWRLKENAQRNGNLYPTHGLGPICQVLKVNRGNRLEYMSSMSSKDFMLEAKAEEMAKTDPRFKAYVGKPFRGNMNISNIMTASGSTIMLQHDVSTPRPYSRLHLISGTKAFAQKYPLPGKIAVGHEDFMGETAMKNLEDIHTPGLVKKIGELAKKIGGHGGMDFMMDWRLIDCLRNGLPMDMDVYDAAAWSVIGPLSEWSVANGSKPIMIPDFTRGNWKNNKIHDIDLHTGGTTGVLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHF2</accession>
    <name>D7VHF2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997399.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10421"/>
    <dbReference type="EnsemblBacteria" id="EFK59504">
        <property type="protein sequence ID" value="EFK59504"/>
        <property type="gene ID" value="HMPREF0766_10421"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032Y0V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112305_1_0_10"/>
    <dbReference type="OrthoDB" id="1997896at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="167" mass="19557" checksum="C2A4EDDA7B3B84E5" modified="2010-10-05" version="1">MSSKFKEVQSFSQWWLWISLIALFIPIYRSGASMSLPESWYRMLAEIVTYVPFYIWLALVVFFVVIKLRTEINDNGIYVDFKPFLWNKTYRFEDIHTYKVVKYSILDYGGWGMRISSAGIAYTTKGKYGLKIALKNGSQILIGTQRPEELSKIMDEFLKSKKADESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHI8</accession>
    <name>D7VHI8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpsS</name>
        <name evidence="7" type="ORF">HMPREF0766_10457</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997495.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10457"/>
    <dbReference type="EnsemblBacteria" id="EFK59540">
        <property type="protein sequence ID" value="EFK59540"/>
        <property type="gene ID" value="HMPREF0766_10457"/>
    </dbReference>
    <dbReference type="GeneID" id="66690490"/>
    <dbReference type="eggNOG" id="COG0185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144911_0_1_10"/>
    <dbReference type="OrthoDB" id="1893906at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="88" mass="10128" checksum="1C2B532E99A8812C" modified="2010-10-05" version="1">MARSIKKGPYIDHNLERKVLSMNETNKKSVIKTWSRRSMISPDFVGHTFAVHNGNKFIPVYVTENMVGHKLGEFAPTRTFRGHAEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHN4</accession>
    <name>D7VHN4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cap</name>
        <name evidence="8" type="ORF">HMPREF0766_10503</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10503"/>
    <dbReference type="EnsemblBacteria" id="EFK59586">
        <property type="protein sequence ID" value="EFK59586"/>
        <property type="gene ID" value="HMPREF0766_10503"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022017_7_2_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="335"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="471" mass="53521" checksum="7B2403A845549C22" modified="2010-10-05" version="1">MTPLYVSKYPPAAYGIFTNMYAWASMINAVLAFGMETTYFRYLQKVEDKDKQRVFNNSFIVIAFFALLFLISANIFSGQISALLNKGQFDRDYQQYIQYFAIILTADALAVVPFAKLRSQGRPIRFAIIKLVNILTMIGLNLFFILIVPVIISDGGAVGDWFAGWFNDGWIGYVFISNLVASVLTLILLLPEMTQFSFQPDRKLIKSMLSYSFPILIANISFIINENLDKIVMPMYLPKEIGDRDNGIYGAVSKLAMFLSIFVQAFRLGAEPFFFSYSKNANARSTYAFIMEYLVIAMMIVMVGISANIEWLKFFIKGDAAHREIFWSGLFIVPLLLFNYVLLGIYMNLSVWYKLSDQTRYALYISGIGALITVVANYFLIPRYSYAGAAFVTFLAYASMVILSYIWGQKNYPIPYKVGKMLIYMLIGAGITYLSNFVFDRNLIIGNALFAVFLAGIFIAERKKIRAVLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHU1</accession>
    <name>D7VHU1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997729.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10560"/>
    <dbReference type="EnsemblBacteria" id="EFK59643">
        <property type="protein sequence ID" value="EFK59643"/>
        <property type="gene ID" value="HMPREF0766_10560"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_385382_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="717" mass="81970" checksum="238C852CDFD697BE" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHW9</accession>
    <name>D7VHW9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">groS</name>
        <name evidence="3" type="synonym">groES</name>
        <name evidence="5" type="ORF">HMPREF0766_10588</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997808.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10588"/>
    <dbReference type="EnsemblBacteria" id="EFK59671">
        <property type="protein sequence ID" value="EFK59671"/>
        <property type="gene ID" value="HMPREF0766_10588"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132825_2_3_10"/>
    <dbReference type="OrthoDB" id="1965002at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="91" mass="9745" checksum="F33DC9C241396CE1" modified="2010-10-05" version="1">MALNIKPIGDRVVIEAAPAEEKTASGIYIPDTAKEKPQSGTVVAVGSGKVDEPLTVKVGDKVLYGKYAGTEITYEGKEYLIMREADIYAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIA3</accession>
    <name>D7VIA3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5689 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998076.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10722"/>
    <dbReference type="EnsemblBacteria" id="EFK59805">
        <property type="protein sequence ID" value="EFK59805"/>
        <property type="gene ID" value="HMPREF0766_10722"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_537355_0_0_10"/>
    <dbReference type="OrthoDB" id="407830at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043744">
        <property type="entry name" value="DUF5689"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18942">
        <property type="entry name" value="DUF5689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5689" evidence="2">
        <location>
            <begin position="52"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="522" mass="56565" checksum="2A668B4DEB3D3780" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIC8</accession>
    <name>D7VIC8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeS assembly protein SufD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sufD</name>
        <name evidence="3" type="ORF">HMPREF0766_10747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998123.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10747"/>
    <dbReference type="EnsemblBacteria" id="EFK59830">
        <property type="protein sequence ID" value="EFK59830"/>
        <property type="gene ID" value="HMPREF0766_10747"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_5_2_10"/>
    <dbReference type="OrthoDB" id="422804at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43575">
        <property type="entry name" value="PTHR43575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01981">
        <property type="entry name" value="sufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="23"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="446" mass="50434" checksum="5A02C0DB7F259181" modified="2010-10-05" version="1">MDEVASRRIDNNMSTLIADSLFQQLVDGFQEQKNASETVALTKLRQDAFDKFRQVGFPTVKNEDWKYTNVHSLVNKTYVLNPDVDIDGLDFSKADIPDLDAHRIILVNGQYVLAFSSLEEEIGLTVKPIDDAAQEGNFSAHFAQYADKTQNPFVALNTALYTSGLYIDVAKGKALQKPIHIVHVATGAEDFFTQTRNLIVLEPNAEAEIIESFITLDGSAKNVQNKVTEIVVQENAKLQHYYLQVSASVSHYLNHTEVYQEKYSLYNNYNCNFPGASFVRNDINVRLDAEYVESHLYGINLTADNQFVDNHTVVDHMKPHCESYEWYKNIPQDTSTAVFNGKIFVREDAQKTNAFQQNNNMLIGDKSTVYTKPQLEIFADDVKCSHGCTMGQFDNDALFYLRARGIGEESARLLLVHAFAFDVTTRFSNPVVRQYVENLVDAGLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIH0</accession>
    <name>D7VIH0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998206.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10789"/>
    <dbReference type="EnsemblBacteria" id="EFK59872">
        <property type="protein sequence ID" value="EFK59872"/>
        <property type="gene ID" value="HMPREF0766_10789"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503333M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132526_1_0_10"/>
    <dbReference type="OrthoDB" id="1921482at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025635">
        <property type="entry name" value="DUF4293"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14126">
        <property type="entry name" value="DUF4293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="157" mass="17771" checksum="2C087411E81FE581" modified="2010-10-05" version="1">MIQRIQTVWLLLAGVTIFALFLFPYLQYIDVAGIGRKLLVSGSYTAVNGESVKEESFILQSIATVVLGLIPVYIIFKFKDRKMQIKLILLQMVLVVLFFFWLYSFSGDILSKTSQYLSASNIGVGFFLFPVAIVFLSLAFGGIRKDERLIKSAERLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIH1</accession>
    <name>D7VIH1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">truA</name>
        <name evidence="9" type="ORF">HMPREF0766_10790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998208.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10790"/>
    <dbReference type="EnsemblBacteria" id="EFK59873">
        <property type="protein sequence ID" value="EFK59873"/>
        <property type="gene ID" value="HMPREF0766_10790"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0101">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014673_0_1_10"/>
    <dbReference type="OrthoDB" id="1075262at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="148"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="257" mass="29562" checksum="D4C73DC4E05BC7BD" modified="2010-10-05" version="1">MELKTKRFFLEIAYQGTAYHGWQIQHNAVSVQEKLNDVLKTLLRKDIETIGAGRTDTGVHARQLFVHFDAIPEGLLLQPDKFVHSLNALLPHDIAVYRLLPVDDQAHARFDATSRSYEYHLHFKKDPFLINASWLTRDIPDVVKMNEACQYLLGRQDFECFSKSNTQVFTNFCDISRAEWLWNTDDHLVFHISADRFLRNMVRAIVGTLLEIGLKGKEPVYIQEVIASKSRSKAGTSVPAHGLYLTEVVYPYISKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIM0</accession>
    <name>D7VIM0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PspC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_10839</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998303.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10839"/>
    <dbReference type="EnsemblBacteria" id="EFK59922">
        <property type="protein sequence ID" value="EFK59922"/>
        <property type="gene ID" value="HMPREF0766_10839"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1983">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017085_0_0_10"/>
    <dbReference type="OrthoDB" id="2022704at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="7">
        <location>
            <begin position="112"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="578" mass="65758" checksum="4398B9350ED419AA" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIU9</accession>
    <name>D7VIU9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR00255 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998471.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10918"/>
    <dbReference type="EnsemblBacteria" id="EFK60001">
        <property type="protein sequence ID" value="EFK60001"/>
        <property type="gene ID" value="HMPREF0766_10918"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076609_1_0_10"/>
    <dbReference type="OrthoDB" id="1509828at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005229">
        <property type="entry name" value="CHP00255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013551">
        <property type="entry name" value="DUF1732"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013527">
        <property type="entry name" value="YicC-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30636">
        <property type="entry name" value="PTHR30636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08340">
        <property type="entry name" value="DUF1732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03755">
        <property type="entry name" value="YicC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00255">
        <property type="entry name" value="TIGR00255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YicC_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1732" evidence="2">
        <location>
            <begin position="207"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK60001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="291" mass="33342" checksum="B92B37857111D6FE" modified="2010-10-05" version="1">MIKSMTGYGIGTHDNEKVKYSVEIKSLNSKFLELNIRLPKAVSDKELTLRGECGKLIERGKVNVMVNVEYTDQTAKASNINAALLKKYYKQLQDIALELGDNQASLFALALDMPEVVTNNDDTVDEEEGSILMAAFKEAVNQFNIFREKEGVVLRNDLEQRVQFILDYLTSVEAKETSRIPLIRERISQYMDEVVGKENIDKNRFEQELIYYIDKLDITEEKVRLRSHCNYFFEALNAPDSNGKKLGFISQEMGREINTLGSKANNAEIQQIVVRMKEELEKIKEQLLNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIX4</accession>
    <name>D7VIX4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998523.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10943"/>
    <dbReference type="EnsemblBacteria" id="EFK60026">
        <property type="protein sequence ID" value="EFK60026"/>
        <property type="gene ID" value="HMPREF0766_10943"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030JEM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1685469_0_0_10"/>
    <dbReference type="OrthoDB" id="1769967at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="156" mass="18509" checksum="D76917DAF9040727" modified="2010-10-05" version="1">MLEFTPDKMTMEMLYIILAASAVRLICWILFANTIRKTLNLIAPENRNILPSQAWFVAVPLFNIYWHFEVARRLCDSLNNEFYDRKIAVEENPTRKEGQIYAWTFLSINIPFPPFILVIAGIMNLIYFITYWVKINQYRVLLKEHNKFVEKEVNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIX7</accession>
    <name>D7VIX7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tricorn protease homolog</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HMPREF0766_10946</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades oligopeptides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S41B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998528.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10946"/>
    <dbReference type="EnsemblBacteria" id="EFK60029">
        <property type="protein sequence ID" value="EFK60029"/>
        <property type="gene ID" value="HMPREF0766_10946"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4946">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005503_0_0_10"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028204">
        <property type="entry name" value="Tricorn_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029414">
        <property type="entry name" value="Tricorn_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012393">
        <property type="entry name" value="Tricorn_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43253">
        <property type="entry name" value="PTHR43253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14684">
        <property type="entry name" value="Tricorn_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14685">
        <property type="entry name" value="Tricorn_PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036421">
        <property type="entry name" value="Tricorn_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005672224" description="Tricorn protease homolog" evidence="10">
        <location>
            <begin position="22"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="TSPc" evidence="11">
        <location>
            <begin position="852"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="550"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="751"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="975"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="1033"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036421-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK60029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1087" mass="123426" checksum="72D54E321F6061D4" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ38</accession>
    <name>D7VJ38_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002150.1">
        <property type="nucleotide sequence ID" value="NZ_GL379779.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11007"/>
    <dbReference type="EnsemblBacteria" id="EFK59173">
        <property type="protein sequence ID" value="EFK59173"/>
        <property type="gene ID" value="HMPREF0766_11007"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033BNB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157927_0_0_10"/>
    <dbReference type="OrthoDB" id="2045697at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="148" mass="16307" checksum="658A0EE3A629925A" modified="2010-10-05" version="1">MKTVKFAFFTMICLILIACKKDSTQGSDNNGIAGRWKLVEVYADPGDGSGKYRSVDSKKQLIFKANGTIEVQNGDLCTVSIDSDNNATSTYKILDKSEPSGNKNRLVIFSCAVMENAPGEFSFEIKGDVLTISYLCFEGCGERYKRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJE7</accession>
    <name>D7VJE7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HDIG domain protein</fullName>
            <ecNumber evidence="7">2.7.7.72</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cca</name>
        <name evidence="7" type="ORF">HMPREF0766_11116</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000603.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11116"/>
    <dbReference type="EnsemblBacteria" id="EFK59000">
        <property type="protein sequence ID" value="EFK59000"/>
        <property type="gene ID" value="HMPREF0766_11116"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015961_6_1_10"/>
    <dbReference type="OrthoDB" id="2018439at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052928">
        <property type="term" value="F:CTP:3'-cytidine-tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CTP:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016437">
        <property type="term" value="F:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="4">
        <location>
            <begin position="24"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_RNAbd" evidence="6">
        <location>
            <begin position="178"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="5">
        <location>
            <begin position="255"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="472" mass="54143" checksum="A389F454F78723D1" modified="2010-10-05" version="1">MSDNLQHPIFSLIKDLAQQTSTECYVIGGYVRDRIMGRPFKNDVDIVVIGSGIEFADKLGEKLNTKVTVYKSFGTAMLVYDGLNVEFVGARKESYRSDSRKPIVENGTLEDDQNRRDFTINAMAYSLNAHNYGALLDPFNGIEDIAQRIIRTPLAPQETFSDDPLRMMRAIRFASQLGFKIDIHTIEAIYNTRERISIISKERITDELNKIILSEKPSVGFKYLFDTGLLELIFPAMYQLHGVDVVEGKGHKDNFYHTLEVLDNVAEYSDDLWLRWAAIMHDIAKPATKRFDKKLGWTFHGHEDKGARMVPKLFAELKLPLHDKMKFVQKLVLLHLRPIVLAKDIVTDSAVRRLLFEAGNDIDALMLLCHADVTTKNEYKKKKYRENFELVKQKLKDVEERDQIRNWQPPITGEDIMTVFNLGPGREVGKIKNAIREAILEGDITNSKEQAYYFMLEQAKQMGLEAKHKLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJE9</accession>
    <name>D7VJE9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11118"/>
    <dbReference type="EnsemblBacteria" id="EFK59002">
        <property type="protein sequence ID" value="EFK59002"/>
        <property type="gene ID" value="HMPREF0766_11118"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3012017_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="56" mass="6605" checksum="8EC059358714FD65" modified="2010-10-05" version="1">MLGIAVHFTYVQEVYGIYSAARIKWDLIEDNADLYTNYLHGIHVVRHWEEELARAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJG0</accession>
    <name>D7VJG0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative monovalent cation/H+ antiporter subunit E</fullName>
            <ecNumber evidence="9">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mnhE</name>
        <name evidence="9" type="ORF">HMPREF0766_11129</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.5" evidence="9"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000623.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11129"/>
    <dbReference type="EnsemblBacteria" id="EFK59013">
        <property type="protein sequence ID" value="EFK59013"/>
        <property type="gene ID" value="HMPREF0766_11129"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086615_3_1_10"/>
    <dbReference type="OrthoDB" id="1987527at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002758">
        <property type="entry name" value="Cation_antiport_E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34584">
        <property type="entry name" value="PTHR34584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01899">
        <property type="entry name" value="MNHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019239">
        <property type="entry name" value="MrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="158" mass="18729" checksum="3E4B0AD4C3E13951" modified="2010-10-05" version="1">MIKQFLMNLLLCFIWIALTGSMYYLNFLFGFLLGFFILWIMNINETDQRYFYRVPKTAGFVLYFLYEMIVANIQVAYDVITPKYFFKPGIIRYPLNARTDFEINLLATIISLTPGTLILDISNDKSALYIHVMYLKDKDKFIAQLKNGFERRLLEIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJG7</accession>
    <name>D7VJG7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11136</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11136"/>
    <dbReference type="EnsemblBacteria" id="EFK59020">
        <property type="protein sequence ID" value="EFK59020"/>
        <property type="gene ID" value="HMPREF0766_11136"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="229"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="626"/>
            <end position="1215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1218" mass="136200" checksum="FD0A4AB4AB425AA7" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJK7</accession>
    <name>D7VJK7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11176</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000710.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11176"/>
    <dbReference type="EnsemblBacteria" id="EFK59060">
        <property type="protein sequence ID" value="EFK59060"/>
        <property type="gene ID" value="HMPREF0766_11176"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_1_1_10"/>
    <dbReference type="OrthoDB" id="233664at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="21"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="345"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="602" mass="68021" checksum="A8723B0BF2F08B3E" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJW7</accession>
    <name>D7VJW7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998686.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11286"/>
    <dbReference type="EnsemblBacteria" id="EFK58569">
        <property type="protein sequence ID" value="EFK58569"/>
        <property type="gene ID" value="HMPREF0766_11286"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_914994_0_0_10"/>
    <dbReference type="OrthoDB" id="1851189at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107307" evidence="2">
        <location>
            <begin position="21"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="282"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="316" mass="35155" checksum="E57C1A8DE0851920" modified="2010-10-05" version="1">MKRFAGLLIALCLFPILVWSQSRNDAGLRGDAGATSGFFDANEPVNFPTGATNWWHLLDVRHSNPANNYAMQFSGSFGDQQLYFRKTDNNPATPWSRVLLETNGKVGIGTDNPQQKLDVKGHISADGSLISTVSDPDIGGTLTLGNPAKTANGVAMYWRIFNMAGVYGNSLQFWAYDAIGCTTGGLCTNRFTIMDNGNVGIGITTPRDKLAVNGNIRAREIKVETNNWPDYVFEEDYKLTPLAEVETFIKANKHLPEVPSAREIEEDGLSLGEMNKLMMKKIEELTLHLIEKDKQLQTQQEELNTLKTQFRTFQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK48</accession>
    <name>D7VK48_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998924.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11367"/>
    <dbReference type="EnsemblBacteria" id="EFK58650">
        <property type="protein sequence ID" value="EFK58650"/>
        <property type="gene ID" value="HMPREF0766_11367"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503122M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184543_1_1_10"/>
    <dbReference type="OrthoDB" id="2036019at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="91" mass="10632" checksum="3F74AD1DC53F9AF6" modified="2010-10-05" version="1">MLDKIIHTIILSCSQATLLVEKRFHMDIPIWKKIQLSIHLKACSSCNSYSKKAGFIEHAITHYIEQHEGDAKKYFTDNKDFIEKVKQNIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK65</accession>
    <name>D7VK65_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cytidine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cdd1</name>
        <name evidence="3" type="ORF">HMPREF0766_11384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998971.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11384"/>
    <dbReference type="EnsemblBacteria" id="EFK58667">
        <property type="protein sequence ID" value="EFK58667"/>
        <property type="gene ID" value="HMPREF0766_11384"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097262_1_0_10"/>
    <dbReference type="OrthoDB" id="1895660at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013171">
        <property type="entry name" value="Cyd/dCyd_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08211">
        <property type="entry name" value="dCMP_cyt_deam_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="164" mass="18174" checksum="9093D2146A2B6B96" modified="2010-10-05" version="1">MRSIDLNITYEHYANIEELSETDKNLCEMAEKALESSYSPYSKFRVGTAIQLESGETFLGSNQENVAYPSGLCAERVALFSIGVMHPDGVIESMAITAQTNAFEITKPITSCGACLQVMAEFEMKQNRPIQVLFYCLNGEVLKVNGIKSLLPFVFVEDRLVASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK82</accession>
    <name>D7VK82_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11401"/>
    <dbReference type="EnsemblBacteria" id="EFK58684">
        <property type="protein sequence ID" value="EFK58684"/>
        <property type="gene ID" value="HMPREF0766_11401"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZFCQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1703132_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107236" evidence="1">
        <location>
            <begin position="30"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="154" mass="17661" checksum="4D1EA9A4CCABEC17" modified="2010-10-05" version="1">MTLKVVDSMAVQIRNIFLLLLCISQSAYAQSKTDIANSKKIYEGIWRDKTNNRNISISYDSTLTYVLINDWTGGMETIKDRSLSEHTDAYKAFIKGDKLILPAENDDHHAPYCEISVSADKLLIYECNGMLNFTDNFLKKSESTNTYIFKRIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK97</accession>
    <name>D7VK97_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, NAD-binding domain protein</fullName>
            <ecNumber evidence="3">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yvaA</name>
        <name evidence="3" type="ORF">HMPREF0766_11416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999054.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11416"/>
    <dbReference type="EnsemblBacteria" id="EFK58699">
        <property type="protein sequence ID" value="EFK58699"/>
        <property type="gene ID" value="HMPREF0766_11416"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_19_1_10"/>
    <dbReference type="OrthoDB" id="1840839at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="138"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="358" mass="40164" checksum="67D61B7E44EF7647" modified="2010-10-05" version="1">MKKIGVGLVGFGISGQVFHAPVMRGVAELELLKVTARKPEQQAILHAKYPQVEIVQTIDDILADDRIELVVIATSNDMHYPFVKQALEAGKHVVVEKPFTNTTVQADELIALAKSKGLQLAVYHNLRFNSDYRTVEKVVKSGELGPVVNLESRYDRFRNYLRPNAWRENNLPGSGIFYDLGAHQIDQTLQLFGKPTGVFADLAIQRTGAQAVDSFDLLLYYPNLRVSLKASMLAKEETTRYLIFGLNGTFTKNGSDPQETLLRAGHFPDEDPHWGEEDPSIYGKLNILKDGEDISKIIPSEKGSYLDFYRNVVDAIRGAAPLIVQPEQARDVIRIIELGYQSQQERRVIPVEDQLIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKI9</accession>
    <name>D7VKI9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999312.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11508"/>
    <dbReference type="EnsemblBacteria" id="EFK58791">
        <property type="protein sequence ID" value="EFK58791"/>
        <property type="gene ID" value="HMPREF0766_11508"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061570_0_0_10"/>
    <dbReference type="OrthoDB" id="1956412at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02199">
        <property type="entry name" value="YjgF_YER057c_UK114_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013813">
        <property type="entry name" value="Endoribo_LPSP/chorism_mut-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001226">
        <property type="entry name" value="Flavodoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14588">
        <property type="entry name" value="YjgF_endoribonc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00201">
        <property type="entry name" value="FLAVODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="29"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="380" mass="40700" checksum="95DA11FC2B8D0A08" modified="2010-10-05" version="1">MRIARVVFLMIWVMIMTNGIEAQQDRTKVLVLFYSDSGGTYELAKEVAKGIEKNGQAIAVIKQTAVSAHPLLKDIPVASADELSAYDGIAFGSPVYFGNISTGMSAFLSKTVDIWQRHALEGIPATVFMSAGSGAGRELAIQGFWNSLAVHGMIIVPSGIRGYEHIDKTTPQGNTVLGTTSLASLKNVARPSESERYLAQLQGEAIAKVASAMKGTFVKAEKTLPVAKADHKNMLKDLGIILPEVPAPAGNYQPFVRSGNLIFINQVALQDGKIVHPGKIGADIDENQARQATEVTMLNVLAVLNKAVDGDLKKVVRCVQLTGIFNTKEGYSKHADLMNIASDLTVKVFGERGKHARGTLGASSLPVNSAVEIQAIFEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKN4</accession>
    <name>D7VKN4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999404.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11553"/>
    <dbReference type="EnsemblBacteria" id="EFK58836">
        <property type="protein sequence ID" value="EFK58836"/>
        <property type="gene ID" value="HMPREF0766_11553"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146109_0_0_10"/>
    <dbReference type="OrthoDB" id="1498264at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="145" mass="17036" checksum="518CA15F5EC66658" modified="2010-10-05" version="1">MTTLTYSIEINATPEKIWQTLWDQENYKVWTNVFSQGSYYKISDFKEGNTIHFLTPRGDGMYSLINKLEYPDYISFQHLGEIVNFEEVPNHDPEWGELYEIYELHPQGQKTTLIVKVDTLTEYTESMNKTFPQALQKAKEVAEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKT4</accession>
    <name>D7VKT4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein HMPREF0766_11603</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999491.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11603"/>
    <dbReference type="EnsemblBacteria" id="EFK58886">
        <property type="protein sequence ID" value="EFK58886"/>
        <property type="gene ID" value="HMPREF0766_11603"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140930_3_0_10"/>
    <dbReference type="OrthoDB" id="1970565at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="104" mass="11412" checksum="42F0CA6E045ED414" modified="2010-10-05" version="1">MFDKLFEAQQKAQEIKKRLDNISVFGEAEGGVIKVVATANKEIREITIDPVFLDNADKEELEELLIVALNKALVQAENVSQSEMQASAQDMLGGFGGLGNLFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKW1</accession>
    <name>D7VKW1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Redoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11630"/>
    <dbReference type="EnsemblBacteria" id="EFK58234">
        <property type="protein sequence ID" value="EFK58234"/>
        <property type="gene ID" value="HMPREF0766_11630"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_1_1_10"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="343"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="488" mass="55363" checksum="D7326FB56A70C670" modified="2010-10-05" version="1">MNPISQYSNQSEKNDKMKKLITIVLLCAYVSAIYGQAKKTRVRVEVSPLKVDSMWVNVYEGKTEPKILKPDANGTFTFSTIVEKGTDARISIDNPISGEVHLYLEPEDDLLIRTDFKENTIFSGKGGGNSSVINELMNMYRTNYGKLDVTKTSLAIFYEQIAEVNKANTDFLDANRSRVSKEFYEDQKVQFYYGALGEDIQMPYLLSLGLKKKLSEVFPSGYIDMFKKMKLSDSLLIHKGYTNFVKDYLPAYLRICRMYQLGRLDSVSTQPETEKRAMEYEQVKEHLTGQSRIMALFGIINNTLQRAKNVTQYKGYIQQFAADGGSQQQVDELQRAYDEALKLSAGAVPPPFTLDDLNGKQVSLQDFAGKVIYIDFWASWCSPCRYEMKNGSPKLHARLADNKDVVFLYISIDDSEEKWRQAIQEDKIEGIHLLSKGGMKSVVAKAFNISGIPRYVIIGRDGRIVDKDATRPSQDITYDKIMDAVKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKW5</accession>
    <name>D7VKW5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor</fullName>
            <ecNumber evidence="4">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpoE8</name>
        <name evidence="4" type="ORF">HMPREF0766_11634</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999576.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11634"/>
    <dbReference type="EnsemblBacteria" id="EFK58238">
        <property type="protein sequence ID" value="EFK58238"/>
        <property type="gene ID" value="HMPREF0766_11634"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_4_1_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014327">
        <property type="entry name" value="RNA_pol_sigma70_bacteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02985">
        <property type="entry name" value="Sig70_bacteroi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="123"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="186" mass="22037" checksum="C7E07A030CB525AA" modified="2010-10-05" version="1">MTNYTAYTDSELINALREGNDAAFTEIYRRYWKRLFYIAAKKLHDPEEAEEIVQQIFVSLWNRREELEISTTLHAYLAVSVKYRIIKVLDKHYHQQKYAESMTSRFLDDSTQEWLAFLDLKDILEKSISDLPEKCQLVFRMSREEHMSQKEIAVALDISEKTVEAHLGKAIKTLRQKLSRFLMLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKW7</accession>
    <name>D7VKW7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11636"/>
    <dbReference type="EnsemblBacteria" id="EFK58240">
        <property type="protein sequence ID" value="EFK58240"/>
        <property type="gene ID" value="HMPREF0766_11636"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1133028_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107351" evidence="1">
        <location>
            <begin position="20"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="236" mass="26944" checksum="CDC1C91FC4A680F7" modified="2010-10-05" version="1">MKRYFILIMLASLLSSVKAQVQQIEDFRDLYMPDPETFLTGFLPAGFTRISHIEALDVIDTFFMERSGKKAAPNYTGTEVNYYKKGNIVMSCGVYNDSIKWHIQQDIRVQEMEGSPGTTQPVSVAKKYWNPYNGFKGTGAYLVEGYVLDAFGLLDLEGKIWPGMTSEKRTNNTLEVGYAYPTISPMRLYPVLVAFDKGYRYKIEVRVFTVNSNRQEAVDNLKWIAKHMEIGIDLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKX9</accession>
    <name>D7VKX9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase, M23 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999611.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11648"/>
    <dbReference type="EnsemblBacteria" id="EFK58252">
        <property type="protein sequence ID" value="EFK58252"/>
        <property type="gene ID" value="HMPREF0766_11648"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025250_0_0_10"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107059" evidence="1">
        <location>
            <begin position="21"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="56"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="143"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="573" mass="64100" checksum="6427C925E18C0630" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKZ4</accession>
    <name>D7VKZ4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">OsmC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ysxC</name>
        <name evidence="1" type="ORF">HMPREF0766_11663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999656.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11663"/>
    <dbReference type="EnsemblBacteria" id="EFK58267">
        <property type="protein sequence ID" value="EFK58267"/>
        <property type="gene ID" value="HMPREF0766_11663"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114057_1_1_10"/>
    <dbReference type="OrthoDB" id="1430018at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="138" mass="15232" checksum="3403C4BD414C9827" modified="2010-10-05" version="1">MKVSLNRVNKAVHFEANSELSDVKVHIDGSKEIGGEGKGVRPMELVLMALGSCSVFDLVSILNKQRQEIEDIHVDVEGKRREQIPNIFTDIHISFTLKGNIDEVKAQKAAELAVKKYCSVHDMLAAGGVNITYSIKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL77</accession>
    <name>D7VL77_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HMPREF0766_11746</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999848.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11746"/>
    <dbReference type="EnsemblBacteria" id="EFK58350">
        <property type="protein sequence ID" value="EFK58350"/>
        <property type="gene ID" value="HMPREF0766_11746"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_426800_0_0_10"/>
    <dbReference type="OrthoDB" id="411818at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009274">
        <property type="term" value="C:peptidoglycan-based cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011812">
        <property type="entry name" value="Pep_trsgly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30400">
        <property type="entry name" value="PTHR30400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0133">Cell shape</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="13">
        <location>
            <begin position="439"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="656"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="668"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFK58350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="694" mass="79881" checksum="1B6995EA2AE6E6FC" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLE5</accession>
    <name>D7VLE5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl hydrolase, family 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_11815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11815"/>
    <dbReference type="EnsemblBacteria" id="EFK58418">
        <property type="protein sequence ID" value="EFK58418"/>
        <property type="gene ID" value="HMPREF0766_11815"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027195_0_0_10"/>
    <dbReference type="OrthoDB" id="1081028at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="5">
        <location>
            <begin position="55"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="348" mass="38228" checksum="BA69D77DB4ADBA50" modified="2010-10-05" version="1">MQGLNKMNMKKFLILGIALLVTLVSCKKDVIWVPDGYGADQFVKPTTPYQPDLSFKTVVYLPSYRTIAAIDTTALESLTHVIYAFMQPKSDGSLVLQGTKENMQAAVRLVKRHNKKIVIAMNGVDSVFTTIVSNPQLRSKFIANIVSFTLQNQFDGVDMDWEYPRSNKANDVTFGIFMQELGAELHSWHRTLSMAVTAGIFAGTVKEGISKEAIDACDFVNLMAYDGIGTDSANPNHHASYGMAERVLNIWITEKGLPANKAVLGLPAYGKTAANAATPYRDLLAMGANANADEFTKDGKTYYYNGENTIRLKTQLARQKGNGIMFWEWGQDAVGAQSLIKVGFAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLL6</accession>
    <name>D7VLL6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PBP_domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000215.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11886"/>
    <dbReference type="EnsemblBacteria" id="EFK58489">
        <property type="protein sequence ID" value="EFK58489"/>
        <property type="gene ID" value="HMPREF0766_11886"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061152_0_0_10"/>
    <dbReference type="OrthoDB" id="1222928at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107019" description="PBP_domain domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="2">
        <location>
            <begin position="48"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="316" mass="35052" checksum="25C008D2E374E698" modified="2010-10-05" version="1">MNKKVSFRIFMLAVATSLAVFTSCSSRSSKDGSDEEKAKHGDILNGRLSVIVDETLLPIIEEQVDVFQNSYKDSKIELVSAPEVKGINLLLQDRAKTAIMTRKLSASEEEYFKKKSISPKVFQIATDAVVFISNTGRADTSITVENVVKILKGENIGQNYSLILDNVNSSTLRQLKDIGKIEKISGKGLKAMENGEEVLSYVAEHTDGIGIISYDQWLNAKRSFQNKDKIRTLSVQNSLTKEGDNKFYLPNQSTLAEGLYVLSRPVYILNYQPDMGLGVGFSAFLTGDRGQRIMLKADLVPATMPGREIIIRDKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM09</accession>
    <name>D7VM09_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nudix-type nucleoside diphosphatase, YffH/AdpP family</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001186.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12006"/>
    <dbReference type="EnsemblBacteria" id="EFK58014">
        <property type="protein sequence ID" value="EFK58014"/>
        <property type="gene ID" value="HMPREF0766_12006"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_6_0_10"/>
    <dbReference type="OrthoDB" id="1831818at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004385">
        <property type="entry name" value="NDP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00052">
        <property type="entry name" value="TIGR00052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="43"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="192" mass="22108" checksum="01F17080C66CC89D" modified="2010-10-05" version="1">MIDKVKIVDTQILSDNWYLLRKITYEYVKKDGTKQIQSREAYDRGNGATILLYNEQQKTVILTRQFRLPTYVNGNSSGMLIETCAGLLDQDNPEDCIRRETEEETGYQIKDVRKVFEAYMSPGSVTEILYFFIAAYDKDMKVTDGGGLEQEEENIEVLEYPIEDAMNMITNGEIKDGKTIMLLQYIKLQGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM11</accession>
    <name>D7VM11_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001191.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12008"/>
    <dbReference type="EnsemblBacteria" id="EFK58016">
        <property type="protein sequence ID" value="EFK58016"/>
        <property type="gene ID" value="HMPREF0766_12008"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3779">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059928_0_0_10"/>
    <dbReference type="OrthoDB" id="1048515at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018756">
        <property type="entry name" value="DUF2314"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10077">
        <property type="entry name" value="DUF2314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2314" evidence="2">
        <location>
            <begin position="14"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="213"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="269" mass="30791" checksum="F62EC55BB57CA7C1" modified="2010-10-05" version="1">MASNEIFFAPGDSPKMMDAFKNAQQTFKYFWREWSWENRRIIPALTVACVKVAFSQRQADQEDPLVEHMWINEVDFDGINIRGVLVNSPNALTNIANGDFVEIPLEQISDWLFAIPESKPKGLSRLFSGNPLPRAYGGFTIQAMRSDMSAQERKEHDKAWGLEFGDYNETLIVSQQKEYPENLEEHPMSKNMREKLIEFIKDNPDELTHADEEGYTLLHRETIAGNKTSVEVLLAAGMDKDAKTNQGYTALDFAAKLDWQHIIPLFETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM49</accession>
    <name>D7VM49_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PLDc_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_12046</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001295.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK58054">
        <property type="protein sequence ID" value="EFK58054"/>
        <property type="gene ID" value="HMPREF0766_12046"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2525848_0_0_10"/>
    <dbReference type="OrthoDB" id="15787at117747"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="PLDc_N" evidence="7">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="84" mass="9770" checksum="3CBBA532DD560D5F" modified="2010-10-05" version="1">MNLLFFNIGTQELILILMLIFMCFIPTILIIISLIDILKRQFTDSGDKILMIVLVFFLPVIGSCVYLFSLRHKYPLIKDQFTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM85</accession>
    <name>D7VM85_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate dehydrogenase or fumarate reductase, flavoprotein subunit</fullName>
            <ecNumber evidence="6">1.3.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sdhA</name>
        <name evidence="6" type="ORF">HMPREF0766_12082</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.1" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001367.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12082"/>
    <dbReference type="EnsemblBacteria" id="EFK58090">
        <property type="protein sequence ID" value="EFK58090"/>
        <property type="gene ID" value="HMPREF0766_12082"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_7_0_10"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011280">
        <property type="entry name" value="Succ_DH/Fum_Rdt_flav_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF53">
        <property type="entry name" value="PTHR11632:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01811">
        <property type="entry name" value="sdhA_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="35"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="5">
        <location>
            <begin position="503"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="638" mass="71173" checksum="AC1CC4AC45D453FE" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMD5</accession>
    <name>D7VMD5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RND transporter, HAE1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">acrD</name>
        <name evidence="6" type="ORF">HMPREF0766_12132</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001462.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12132"/>
    <dbReference type="EnsemblBacteria" id="EFK58140">
        <property type="protein sequence ID" value="EFK58140"/>
        <property type="gene ID" value="HMPREF0766_12132"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_10"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="873"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="898"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="925"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="969"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1002"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="5">
        <location>
            <begin position="370"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1056" mass="114610" checksum="C392A8DE3E0DC4B0" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMF2</accession>
    <name>D7VMF2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">OMP decarboxylase</fullName>
            <shortName evidence="4">OMPDCase</shortName>
            <shortName evidence="4">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">pyrF</name>
        <name evidence="6" type="ORF">HMPREF0766_12149</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the OMP decarboxylase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001491.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12149"/>
    <dbReference type="EnsemblBacteria" id="EFK58157">
        <property type="protein sequence ID" value="EFK58157"/>
        <property type="gene ID" value="HMPREF0766_12149"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060704_1_0_10"/>
    <dbReference type="OrthoDB" id="1181405at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01215">
        <property type="entry name" value="OMPdecase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="PTHR43375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="5">
        <location>
            <begin position="16"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="277" mass="30796" checksum="3850531954A5B9EF" modified="2010-10-05" version="1">MTRAALIQQIKTKHSFLCVGLDTDLTKIPEHLLDNEDPIFSFNKAIIEATADLCVAYKPNIAFYESYGMRGWESLRKTWEALPKDCFSIADAKRGDIGNTSKMYASAFFDQQNSGMSFDSITIAPYMGKDSVTPFLDFEGKWAIVLALTSNPGSLDFQNFTNTSGKQLFEEVLDKVNTWGSDEQIMYVVGATRGEGFIKIREHAPDHFLLVPGVGAQGGSLEDVCKYGMNKDCGLLVNSTRGIIYASNGKDFAERAREEALILQKEMEQQLMLHGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMU0</accession>
    <name>D7VMU0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Mannonate dehydratase</fullName>
            <ecNumber evidence="5 6">4.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-mannonate hydro-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">uxuA</name>
        <name evidence="7" type="ORF">HMPREF0766_12310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the dehydration of D-mannonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O</text>
            <dbReference type="Rhea" id="RHEA:20097"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17767"/>
            <dbReference type="ChEBI" id="CHEBI:57990"/>
            <dbReference type="EC" id="4.2.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Carbohydrate metabolism; pentose and glucuronate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the mannonate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.8" evidence="5 6"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992796.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12310"/>
    <dbReference type="EnsemblBacteria" id="EFK57237">
        <property type="protein sequence ID" value="EFK57237"/>
        <property type="gene ID" value="HMPREF0766_12310"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058621_2_0_10"/>
    <dbReference type="OrthoDB" id="907794at2"/>
    <dbReference type="UniPathway" id="UPA00246"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008927">
        <property type="term" value="F:mannonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006064">
        <property type="term" value="P:glucuronate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00106">
        <property type="entry name" value="UxuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004628">
        <property type="entry name" value="Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30387">
        <property type="entry name" value="PTHR30387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03786">
        <property type="entry name" value="UxuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016049">
        <property type="entry name" value="Man_dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00695">
        <property type="entry name" value="uxuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="386" mass="43605" checksum="A0BCE11DE596323B" modified="2010-10-05" version="1">MNRLEQTWRWYGPNDPVSLQDVKQAGATGIVSALHHIPHGEIWPLGDIKERKAIIEAAGLTWSVVESVPVHEAIKTKSENAGLYIENYKQSLRNLAECGIHTVCYNFMPVLDWTRTHLDYGMTDGSKALYFNWFDLAFFDLYVLKRAGAEQDYPQAVLEEALAKSHQYTKADIDKLSENILMGIPSEKGITLEDLTQSIHVYQHIGKDGLRDNLLWFLSQIAETCEQNQIRMTIHPDDPPYPILGLPRIASDKDDFEFIIKGVDQTFNGVCFCTGSLGAGVSNNVLDIFNVVKDRIYFAHLRNVKKDVFGNFYEADHLDGDVDMYHVMKLLTAENQKREKAIPFRPDHGHQMLDDLNKVTNPGYSAIGRLRGLAELRGLELGILGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMV7</accession>
    <name>D7VMV7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992830.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12327"/>
    <dbReference type="EnsemblBacteria" id="EFK57254">
        <property type="protein sequence ID" value="EFK57254"/>
        <property type="gene ID" value="HMPREF0766_12327"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_459141_0_0_10"/>
    <dbReference type="OrthoDB" id="346998at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="594" mass="67551" checksum="6F742841E43EEA41" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMY0</accession>
    <name>D7VMY0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992864.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12350"/>
    <dbReference type="EnsemblBacteria" id="EFK57277">
        <property type="protein sequence ID" value="EFK57277"/>
        <property type="gene ID" value="HMPREF0766_12350"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033XK8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1884461_0_0_10"/>
    <dbReference type="OrthoDB" id="2141756at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038468">
        <property type="entry name" value="MmpS_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107451" evidence="1">
        <location>
            <begin position="26"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="135" mass="14743" checksum="3723688B9E909F46" modified="2010-10-05" version="1">MKKMNFKSGILAALTVLLGITLLYSCDEDDDNVSIYPKNVKIAYSITSKSKDIKIGKLTFTDSTGKDSVQTNGQVPFNKSFPRLISKQGEKAKLAFASAGNGEITFEIKVDDQVVKTESFKSAADSLKGSIEYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN20</accession>
    <name>D7VN20_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phage_int_SAM_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992916.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12390"/>
    <dbReference type="EnsemblBacteria" id="EFK57317">
        <property type="protein sequence ID" value="EFK57317"/>
        <property type="gene ID" value="HMPREF0766_12390"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033139_8_0_10"/>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025269">
        <property type="entry name" value="SAM-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13102">
        <property type="entry name" value="Phage_int_SAM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_int_SAM_5" evidence="3">
        <location>
            <begin position="102"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="419" mass="48190" checksum="E7C46B995E341E28" modified="2010-10-05" version="1">MATLSAVILDHHFKGDRTVNVKIRITQKGKSVYIPTDLYIGARNIDNRGKLRSAYIDRYVSPVLNRFRDYLTEEISRSYSAQRIKDFILKKEEPVQLAEDIDFIAFCYEYIKGLMDDDRVSSAVPLKSVVNSLADYFKGRLNPAMLTSKILVEYENYLRTDRTLVRTNQHGNKVKTVSYGLTDAGVFKHMSNLRILFNACKFKYNDDDIGNIVIFNNPFGKYKLKPSRNNKKRNVDIDHLIKLFRYKPEGRREQLAKDMFFLSFFLCGINAVDIYKSDMTPISGRLGYNRSKTQGKRNDSAFISIAVPDVVVAYFKEYRGTIAKRYSDARNFTKALNIGLKQIGEKLGFMLTFYSARHSFATVARNNCRCTKDDIADALNHVVNGMSITDGYLAKDWSIVDEVQSKVLKFFFDKLNKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN47</accession>
    <name>D7VN47_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992956.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57344">
        <property type="protein sequence ID" value="EFK57344"/>
        <property type="gene ID" value="HMPREF0766_12417"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50335WK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2058080_0_0_10"/>
    <dbReference type="OrthoDB" id="2012312at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="121" mass="14612" checksum="786981733A164364" modified="2010-10-05" version="1">MSLSNFFRINLPYGIARNSNNEWIAFNREYLPIGWNDVGFKRNDSFKNSEYGDLPLYTKYKNISKNKIDEIIYDKELIRLDDKNEIEVIWFYNDKTNPTVSNKWDSYFKIIEKLAHWEVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNK9</accession>
    <name>D7VNK9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993163.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12579"/>
    <dbReference type="EnsemblBacteria" id="EFK57506">
        <property type="protein sequence ID" value="EFK57506"/>
        <property type="gene ID" value="HMPREF0766_12579"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZB0D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_605342_0_0_10"/>
    <dbReference type="OrthoDB" id="1529847at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="533" mass="62180" checksum="C2F3011323AFD67A" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNM9</accession>
    <name>D7VNM9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993188.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12599"/>
    <dbReference type="EnsemblBacteria" id="EFK57526">
        <property type="protein sequence ID" value="EFK57526"/>
        <property type="gene ID" value="HMPREF0766_12599"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068207_0_0_10"/>
    <dbReference type="OrthoDB" id="1631847at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="9"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="255" mass="29198" checksum="368EBE2A984E6AAA" modified="2010-10-05" version="1">METKKKTLKISFSTPKGGVGKSTMTALLSSVLHYRLAFNVLVMDCDFPQHSLANMRERDLKTIMQNDYHKRAAMKLYQSINKKAYPIISCKPEDALSKALEYVNQSAIEPDITFFDLPGTANTKGVLTTLRTMDFIFSPISADRLVMESTLSFTKAFLGLPETEESNEDQKMWMFWNQVDGREKTGIYEAYQSVINELDLSVMNSRIMDSKRFRKETDDTPNSVFRSSLLPAEPQLMKVTRLDLFIEEFLKIVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNQ9</accession>
    <name>D7VNQ9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993233.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12629"/>
    <dbReference type="EnsemblBacteria" id="EFK57556">
        <property type="protein sequence ID" value="EFK57556"/>
        <property type="gene ID" value="HMPREF0766_12629"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_3_2_10"/>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="109" mass="12305" checksum="E8043CEEBC8C5E69" modified="2010-10-05" version="1">MGLTKSEIFTDEQNRLASLFKVLAHPARVAILQYIINQKACICNDLVEELGLAQATISQHLKELKSIGIIQGTIEVKSVCYCIDKNVWKKIQADFNSFFDQEVKVNKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNU2</accession>
    <name>D7VNU2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative toxin-antitoxin system, toxin component, Fic family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993291.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12662"/>
    <dbReference type="EnsemblBacteria" id="EFK57589">
        <property type="protein sequence ID" value="EFK57589"/>
        <property type="gene ID" value="HMPREF0766_12662"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055403_0_1_10"/>
    <dbReference type="OrthoDB" id="1838027at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018873">
        <property type="entry name" value="KilA-N_DNA-bd_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10543">
        <property type="entry name" value="ORF6N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORF6N" evidence="1">
        <location>
            <begin position="15"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="297" mass="33746" checksum="88604E89D5A23361" modified="2010-10-05" version="1">MNSNAIISRKEIENLIYTIRGKQVMLDSDLAKLYQVETKNLNKAVKRNIERFPQSFCFQLTEEEAENLRFQIGTSSLNYGGRRYLPYVFGEQGVAMLSAVLRSEIAVKVSIEIMNAFVEMRRLLIGNAALFSRMDKIELKQIEADGKFEEIFKALESGKLHSDKGIFYDGQIFDAYTFVADIIRSAQRSIILIDNYVDDTVLTLLGKRGQSVSATIYTKNISNQLQLDLQRYNSQYPAINVHAFAHAHDRFLIIDGTELYHIGASLKDLGRKWFAFSKMSAEASKMISLLNGILREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNY1</accession>
    <name>D7VNY1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_12701</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993351.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12701"/>
    <dbReference type="EnsemblBacteria" id="EFK57628">
        <property type="protein sequence ID" value="EFK57628"/>
        <property type="gene ID" value="HMPREF0766_12701"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_10"/>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="259" mass="29901" checksum="B1468392C0819F46" modified="2010-10-05" version="1">MEAIEIRNLAFHYGKQAVLDGLRATFYKGELSVILGRNGSGKSTLFNILAGVQREYQGQIHINGVERRAIKVGNANGIRLGFMTQFHQTNFPFSVYDVVMTGRASFSRFSPKEEDREQVRNVLKRFELWKYKDKPYTRLSGGERQLVLLCRVLVQDPDIILLDEPTNHLDLHYQVAVLDNLKKLVEEGKTVICIMHDPNLAFLYGDRFFLMQQQVITSLEGKNTDSIHHLLEQAYQVRLEQIPHRGKIIILPDPQHHYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPK0</accession>
    <name>D7VPK0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exonuclease SbcCD, C subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993773.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12920"/>
    <dbReference type="EnsemblBacteria" id="EFK57847">
        <property type="protein sequence ID" value="EFK57847"/>
        <property type="gene ID" value="HMPREF0766_12920"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004785_1_2_10"/>
    <dbReference type="OrthoDB" id="1143316at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="2">
        <location>
            <begin position="6"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="292"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="524"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="669"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1012" mass="117675" checksum="F0915DDB794EEB0D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPK4</accession>
    <name>D7VPK4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993778.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12924"/>
    <dbReference type="EnsemblBacteria" id="EFK57851">
        <property type="protein sequence ID" value="EFK57851"/>
        <property type="gene ID" value="HMPREF0766_12924"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032SBF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138485_0_0_10"/>
    <dbReference type="OrthoDB" id="1906716at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030077">
        <property type="term" value="C:plasma membrane light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.468.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023119">
        <property type="entry name" value="Multihaem_cyt_PRC_cyt_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003158">
        <property type="entry name" value="Photosyn_RC_cyt_c-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02276">
        <property type="entry name" value="CytoC_RC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="136" mass="15306" checksum="8F1D6EEF270C4041" modified="2010-10-05" version="1">MRLQKITIVTVIFSAIIALTAFIPAPQPAQEKKAKNLKVLPKNISNEELDKVMDNFKVALGVKCNFCHAKSTTDPQKMDFASDENPHKDIARSMMKMTQKINKKYFTHKDEKSGTMAQISCMTCHNGKKHPEVVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPS6</accession>
    <name>D7VPS6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative endo-beta-N-acetylglucosaminidase F1</fullName>
            <ecNumber evidence="3">3.2.1.96</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993876.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12996"/>
    <dbReference type="EnsemblBacteria" id="EFK57923">
        <property type="protein sequence ID" value="EFK57923"/>
        <property type="gene ID" value="HMPREF0766_12996"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027259_0_0_10"/>
    <dbReference type="OrthoDB" id="1152973at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013728">
        <property type="entry name" value="DUF1735"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08522">
        <property type="entry name" value="DUF1735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107495" evidence="1">
        <location>
            <begin position="31"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1735" evidence="2">
        <location>
            <begin position="50"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="466" mass="51574" checksum="42E4209BE2D22EBB" modified="2010-10-05" version="1">MKNYIIKAMCNSLIVGLVFTLILTSCNKNTVTLPDPYDVYADMKTSGFLVNSENNQNTVQFNVIKKNTGISIDKDQLNLNFKISAPVAMDITGKVSVNETLLTSYNSDHQTSYQLLPANTYVLSENTAVSISKGNTLSNAVSLKMTNLNSLVLGQTYLLPVSLSSVSDASLSVHESFKTTYLMVKVDANEFPNTDKPNGIKSVLYVETGSNSILNAGRYVMKSSGKPFFDMAILFAPNIGWKDKKPVVTLGSAYDQLNDTEKYIRPLQRKGIKVLVSFLGAMQNYNMEEIEKISLQIKQIVVRYGLDGINFDDEYQSYNGIEMPVANNYSYTMLIKRCKELMPDKIVSFYNIGTTPQVANGVTPGDYLDYAWQAYYGSYYAPSVPGLTDKKKLGPGAAWIPAAGGQGGNVTDVNTAENIARRTIQDGYGVMVFYDLTATAQMTWMERVGKALYNEDVITVEDPYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPW2</accession>
    <name>D7VPW2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="7">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ogt</name>
        <name evidence="10" type="ORF">HMPREF0766_14322</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MGMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996436.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14322"/>
    <dbReference type="EnsemblBacteria" id="EFK57119">
        <property type="protein sequence ID" value="EFK57119"/>
        <property type="gene ID" value="HMPREF0766_14322"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_2_10"/>
    <dbReference type="OrthoDB" id="1327994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_1N" evidence="9">
        <location>
            <begin position="10"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_binding_1" evidence="8">
        <location>
            <begin position="83"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="7">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK57119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="172" mass="18917" checksum="C2870206C5756F0D" modified="2010-10-05" version="1">MESNKKSEYKDMPSVLGVIRLVATDAGLAAILWEGEDYTRTKLSVPERNDQNPILLKTEQQLTEYFAKTRTTFDIPLDFSGTEFQKKVWKALLNVPFGKTITYGGLAKILGDIKAVRAVGGALNKNPVAIIVPCHRIVGATGKMVGFAGGIANKTILLNLENKYKMPSLFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ37</accession>
    <name>D7VQ37_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13091"/>
    <dbReference type="EnsemblBacteria" id="EFK55888">
        <property type="protein sequence ID" value="EFK55888"/>
        <property type="gene ID" value="HMPREF0766_13091"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_854427_0_0_10"/>
    <dbReference type="OrthoDB" id="1506370at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="325" mass="38142" checksum="0856E783C979343B" modified="2010-10-05" version="1">MKQGMILFWLLYMLFFCIPFPIGLHLAIYDDSRLPSNSVLWSSVFLSLSVVIWIYLLSFYINQFLIKNVRTKQEISRIFQSGIRRRAVVTESAVVKYDDKRESNLMRIKLQFENRNGVSISDEQFFWDTRPYEYRFEQGKEVSVLLNDNPDKEPYFIMEEQRTQYNTSGILIRVAILILFIAYIAGLYIYFYHRESKGYGWHFVSFTHPVVMTGFSMLVLVFLYKRLVKKFIFGKKGDRNLLYSGAQAVARINQVRQTGLTVNDQPEVRFEVSFTDTKGQLRHAAYKKIISLIDLPLIPRSGEINILYDTDKPENIIIPDLLAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQD1</accession>
    <name>D7VQD1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994205.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK55982">
        <property type="protein sequence ID" value="EFK55982"/>
        <property type="gene ID" value="HMPREF0766_13185"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031FA6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1336813_0_0_10"/>
    <dbReference type="OrthoDB" id="2140666at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="205" mass="22980" checksum="56E1F70312246E17" modified="2010-10-05" version="1">METEGFIIGDQVALLNDSLQATDTISAEGKLVKISGISEQFYPLTENDTGICNKYSYVRIQLQDEQAIINGKYIYSATSEEAPKEIQIEKDQYSFVRLENYNALSDTSVSCDMHTPLLFTNSGDNYKGLLKLVNNDIYQSEYPYLELMANAIAHDVITEINTKGNQIILYIRRTGKQSLANIVVAIKKDALNGYSAEVKSIENIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQF6</accession>
    <name>D7VQF6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13210"/>
    <dbReference type="EnsemblBacteria" id="EFK56007">
        <property type="protein sequence ID" value="EFK56007"/>
        <property type="gene ID" value="HMPREF0766_13210"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2669193_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="75" mass="8658" checksum="5FE042AD4ED72DE5" modified="2010-10-05" version="1">MLSLLRALDCLLSVENNLMFIDTKSMFIHVFNKAYPFPFHPIPSAMLTRVIVTVVSYILQKTFSFKGKKRLIGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQJ3</accession>
    <name>D7VQJ3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994337.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13247"/>
    <dbReference type="EnsemblBacteria" id="EFK56044">
        <property type="protein sequence ID" value="EFK56044"/>
        <property type="gene ID" value="HMPREF0766_13247"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032RBB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1330215_0_0_10"/>
    <dbReference type="OrthoDB" id="1552816at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107153" evidence="1">
        <location>
            <begin position="23"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="208" mass="23900" checksum="0AD55351B19CFCFF" modified="2010-10-05" version="1">MKAAKRITLFLILCCADFTLFAQHPEYSPEIILGNRAFSYIHQVSYRFSPKWKLDNLTLFDTEYGDKKNDIFFIRNSLAYSLHKNISFSTAVGLKNPGIFTSVSAQYQLRHRNFSLSYAAGITYQKGITLEQSFNALYTPVITPVIHGYFKIQAVANINTREYQRGFQQLRTGLQINGNIYGLAFNLDQFNNSHKTLENTGIFLKHNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQK2</accession>
    <name>D7VQK2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994355.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13256"/>
    <dbReference type="EnsemblBacteria" id="EFK56053">
        <property type="protein sequence ID" value="EFK56053"/>
        <property type="gene ID" value="HMPREF0766_13256"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_794066_0_0_10"/>
    <dbReference type="OrthoDB" id="1438588at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="352" mass="40097" checksum="28D3E935E570058D" modified="2010-10-05" version="1">MKKLDPALKQLLHEGTVIPAHPLALHEDRSIDEEGQRLLSRYYMASGAGGIAVAVHSTQFEIRDPKINLFETVLQWAAEEVQNANLDRPFIKVAGICGPTEQAVREAETAVRYNYDIGLLSMGGLQDWTEEQILERVRKVAEIMPVFGFYLQPSVGGRIFSYAFWQAFVEIDNVEAIKCASFNRYQTLDVMRALANSSRRNDIAMYTGNDDNIIADLLSTYRFPVNGESVEINFKGGLLGHWAVWTQKAVALMQEIKEYRKHKTDEKADELLSRNIEVTDANAAFFDPAHHFHGCIPGIHEVLRRQGLMKGIWCLNPNEKLSPGQKEEIDRIYREYPHLNDDVFVQEFLKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQP2</accession>
    <name>D7VQP2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994411.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13296"/>
    <dbReference type="EnsemblBacteria" id="EFK56093">
        <property type="protein sequence ID" value="EFK56093"/>
        <property type="gene ID" value="HMPREF0766_13296"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50314CG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1266216_0_0_10"/>
    <dbReference type="OrthoDB" id="2041953at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="216" mass="24790" checksum="F44985FA10E93767" modified="2010-10-05" version="1">MKKEELERLKAKYWAGESSLEEDRIIREAEQADPYFSVLKAIEEEEMNLQFDDFIHTVAQDQQQNDKLNIRSIYRKVSVAASLLFVAGGIWYFSSTQKEHTELAKTDDKKPHLTAQVDKKAPQQQEVNTPQSQIETPVRIAAIRQLQKKKVIKKEVTKTVSVPAPESELYVEVNGVKIYNEEEALKITEEVLSLASNNIRKGLEATRNIKYLTIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQT3</accession>
    <name>D7VQT3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MaoC-like protein</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994463.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13337"/>
    <dbReference type="EnsemblBacteria" id="EFK56134">
        <property type="protein sequence ID" value="EFK56134"/>
        <property type="gene ID" value="HMPREF0766_13337"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108911_0_0_10"/>
    <dbReference type="OrthoDB" id="1380653at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03450">
        <property type="entry name" value="NodN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039375">
        <property type="entry name" value="NodN-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="152" mass="17401" checksum="FD116C83EE844751" modified="2010-10-05" version="1">MLIINNFEEYKSHEGKELGLSDWHIIDQEQINRFADATLDHQWIHIDSKKAETDSPFKTTIAHGYLTLSLIPYLWKQIADVRNIKMEVNYGIEQLKFGQAVTIDSAVQLKAKLISAVNLRGVTKVTIEATLNIKDQTKPAYVGNVIFLYHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQU6</accession>
    <name>D7VQU6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_13350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13350"/>
    <dbReference type="EnsemblBacteria" id="EFK56147">
        <property type="protein sequence ID" value="EFK56147"/>
        <property type="gene ID" value="HMPREF0766_13350"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131484_0_0_10"/>
    <dbReference type="OrthoDB" id="1939800at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="59"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="150" mass="16992" checksum="FCEE675919BD77C9" modified="2010-10-05" version="1">MVFCITSCTSENSKSDRQKNQEETPDKTKEQAPVHDYLMEGNKGVGTINQFERKPFDSRLADQGNKLFIVKCTICHEVKEDKIGPALYGVTKKRTPEWILNMILTPDQMLAKDPDAIALSQSYDGMMTAMGLNEQEAKSILEYLRKEDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQV5</accession>
    <name>D7VQV5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase, M16 family</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_13359</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994492.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13359"/>
    <dbReference type="EnsemblBacteria" id="EFK56156">
        <property type="protein sequence ID" value="EFK56156"/>
        <property type="gene ID" value="HMPREF0766_13359"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008156_0_0_10"/>
    <dbReference type="OrthoDB" id="1188251at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="3">
        <location>
            <begin position="46"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="208"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="694"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="936" mass="106744" checksum="2EB1C91657394663" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQY0</accession>
    <name>D7VQY0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994522.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13384"/>
    <dbReference type="EnsemblBacteria" id="EFK56181">
        <property type="protein sequence ID" value="EFK56181"/>
        <property type="gene ID" value="HMPREF0766_13384"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1110838_0_0_10"/>
    <dbReference type="OrthoDB" id="1574620at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="127"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="250" mass="29132" checksum="D606202118BEEC13" modified="2010-10-05" version="1">MAIKRKSFTGVWNIIRFNWHFYVIAALILIVSLFLYPYLPHDFQFILITVTIIAGISIISSLIVSCYIYDLSDLYKLKWLGNTDHKQVLNINAGFDETSIILKSISPDIHLTICDFYDPQKHTEISIKRARKIYPAKDAVCVQTTRLPFEDNTFDLCLAIFSVHEIRQEDERISFFRELNRITKSGGQIMITEHLRDIPNFLAYTIGFLHFYGKKNWIHIFREAGFRLKEEIKVTPFVSTFILEKNGITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR36</accession>
    <name>D7VR36_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma factor regulatory protein, FecR/PupR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994603.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13440"/>
    <dbReference type="EnsemblBacteria" id="EFK56237">
        <property type="protein sequence ID" value="EFK56237"/>
        <property type="gene ID" value="HMPREF0766_13440"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050192_1_0_10"/>
    <dbReference type="OrthoDB" id="1381035at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032508">
        <property type="entry name" value="FecR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16344">
        <property type="entry name" value="DUF4974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="163"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4974" evidence="3">
        <location>
            <begin position="300"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="370" mass="41067" checksum="621789C143CCFB86" modified="2010-10-05" version="1">MKESEKLLFKYIEGKATSPQQIIVEKWYADLEVPDNSGFTDLEKQQQLDTIRQQLPGYKVQQVTLWPRIVVAVSVLLIITAGIFYYKSAFQIDQTHALTHESDISPGHTGATLTLADGRKIILSAAGAGQIAEEAGMRVTKTADGQIMYEILEAEATSDKTNTLSTANGQTYVLTLPDQTKIWLNAASSLTYNTTLYSEGKRQVQLQGEAYFEVAKDPKHPFIVKSGSQSVEVLGTHFNINSYADEEAISTTLIEGSVRVEEGERKRILKPGQQAVNTGTAMTVQTVDTEIAVDWKDGDFVLNHVDFKSAMRKIARWYDVEVIYDPNVPADIETGGWISRKKNLSAILKLIESSGLVHFKVEGRKVYVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR84</accession>
    <name>D7VR84_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fmt</name>
        <name evidence="2" type="ORF">HMPREF0766_13488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13488"/>
    <dbReference type="EnsemblBacteria" id="EFK56285">
        <property type="protein sequence ID" value="EFK56285"/>
        <property type="gene ID" value="HMPREF0766_13488"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058336_0_4_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="251" mass="28499" checksum="A81B7CC57C43187B" modified="2010-10-05" version="1">MPYMKNIFLKEEQKFMEGARSRWRELKYVGGVVYQFIKGFRALHFIGPCITVFGSARFKEDHPYYALARKVSAEVSRLGFTIMTGGGPGIMEAANRGARDAGGPSVGCNIVLPHEQHPNPYLDKYINIEYFFVRKELLRKYSFGIITLPGGFGTLDELFETITLIQTGKIKKFPIVIMGLEYHRHIQEHIAIMAEAGTISPDDQELILFTDDIDEAIGHIRRHAEESRILKLQPPKKASWVLGEKTLKKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRC2</accession>
    <name>D7VRC2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994709.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13526"/>
    <dbReference type="EnsemblBacteria" id="EFK56323">
        <property type="protein sequence ID" value="EFK56323"/>
        <property type="gene ID" value="HMPREF0766_13526"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097820_0_0_10"/>
    <dbReference type="OrthoDB" id="1282004at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="2">
        <location>
            <begin position="50"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="132" mass="14992" checksum="B622CCA965B424B0" modified="2010-10-05" version="1">MIKEIKMFSLLIMMIWLIHNVHAQSPAIYDTLSIGNIKQVVSYSGSKDAPVILFLHGGPGSSRMKQAEVFSNMLQKHFMVVQWDQRGAGRTEALNKSLVPITLDLMVNDTFELIKLLLKRFNQKKLYLVGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRE6</accession>
    <name>D7VRE6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ylmE</name>
        <name evidence="5" type="ORF">HMPREF0766_13550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994737.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13550"/>
    <dbReference type="EnsemblBacteria" id="EFK56347">
        <property type="protein sequence ID" value="EFK56347"/>
        <property type="gene ID" value="HMPREF0766_13550"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059988_1_2_10"/>
    <dbReference type="OrthoDB" id="1423012at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="26"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="244" mass="27299" checksum="5B2B2A6C265CB6CB" modified="2010-10-05" version="1">MSQEIIDNIALIQARIAQACTAAGRDRSEVKLLLATKTVPADRIKAALQAGHTLIAENKVQEIKEKYEALKDIPHVNHFIGHLQTNKVKDLLKYDITCVQSLDRAELAQKLHQRLKAENRTIEVFIQVNTSFEESKFGVSPHKVVDLVKEVALLDTLKIKGLMTIGLLSTESEKVRQCFRLLKEIQQQIIALDIPHVEMRELSMGMSGDLETAIAEGATIVRVGTAIFGQRPTADSYYWNEKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRS3</accession>
    <name>D7VRS3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fasciclin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13677"/>
    <dbReference type="EnsemblBacteria" id="EFK56474">
        <property type="protein sequence ID" value="EFK56474"/>
        <property type="gene ID" value="HMPREF0766_13677"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031281_4_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107857" evidence="1">
        <location>
            <begin position="39"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="59"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="205" mass="22106" checksum="F903547DD2B60958" modified="2010-10-05" version="1">MRERKQIKRINFQKQDIMRATSKLIVLSLFSLSLICGANVSAQQKEKTVMVGGAPMYPSKNIVENAVNSKDHTTLVAAVKAAGLVETLSSKGPFTVFAPTNEAFAKLPAGTVESLVKPENKEKLTTILTYHVVAGKHDAKSIMNMVKAGGGKASVATVQGEKITFWVKGKDLYVRDSKGNDAKVTIADVNQSNGTIHVIDHVLMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRS6</accession>
    <name>D7VRS6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994997.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13680"/>
    <dbReference type="EnsemblBacteria" id="EFK56477">
        <property type="protein sequence ID" value="EFK56477"/>
        <property type="gene ID" value="HMPREF0766_13680"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133146_0_0_10"/>
    <dbReference type="OrthoDB" id="2075088at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009325">
        <property type="entry name" value="DUF983"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06170">
        <property type="entry name" value="DUF983"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="132" mass="15367" checksum="0CAAC26D0E1D4575" modified="2010-10-05" version="1">MKYTLSNELKSALEGKCPRCRKGDLFKAPLFSFRSKKMNETCPHCGLKFEKEPGYFYVAMYISYAFNVAELLTACFATYFLTNNLESPWLYLGVSLSAAILMAPVNYRYSRVVLLYWLTPSFRYRPDIYDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRU2</accession>
    <name>D7VRU2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-glycanase_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13696</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995043.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13696"/>
    <dbReference type="EnsemblBacteria" id="EFK56493">
        <property type="protein sequence ID" value="EFK56493"/>
        <property type="gene ID" value="HMPREF0766_13696"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_493279_0_0_10"/>
    <dbReference type="OrthoDB" id="284288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016715">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025524">
        <property type="entry name" value="DUF4412"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015197">
        <property type="entry name" value="PngaseF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015196">
        <property type="entry name" value="PngaseF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043022">
        <property type="entry name" value="PngaseF_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14371">
        <property type="entry name" value="DUF4412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09113">
        <property type="entry name" value="N-glycanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09112">
        <property type="entry name" value="N-glycanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01290">
        <property type="entry name" value="N-glycanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="SSF49742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107508" description="N-glycanase_N domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="N-glycanase_N" evidence="3">
        <location>
            <begin position="205"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="554" mass="62339" checksum="17389F40AA893CF1" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRV7</accession>
    <name>D7VRV7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995075.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13711"/>
    <dbReference type="EnsemblBacteria" id="EFK56508">
        <property type="protein sequence ID" value="EFK56508"/>
        <property type="gene ID" value="HMPREF0766_13711"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7JA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089286_1_1_10"/>
    <dbReference type="OrthoDB" id="1834166at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025636">
        <property type="entry name" value="DUF4294"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14127">
        <property type="entry name" value="DUF4294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="213" mass="24591" checksum="E7B19D7D881381B8" modified="2010-10-05" version="1">MKIIYVPGFVLFLLLPLFGKGQTLIKPQYGGGEPEVVEHYATTTLDDGEVVPWFPIPEVVVTGKRIWSSEDAKKEYLRLRRNVLRVLPYAIYAQKRYDQLDRDLALVNDKKEQKRLIKACEEEIKEKFTKEIKNLSVSQGKILIKLVDRQTGKTSYDMVREMKGGLTAFFYQGIAKVFGHNLKSTYDSQEDFEIENIIRSFERTRPVASPPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRX3</accession>
    <name>D7VRX3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995119.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56524">
        <property type="protein sequence ID" value="EFK56524"/>
        <property type="gene ID" value="HMPREF0766_13727"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1804956_0_0_10"/>
    <dbReference type="OrthoDB" id="1875479at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="143" mass="16698" checksum="C8FB516354A7F201" modified="2010-10-05" version="1">MEEEFIHTEAKVALIQKLKQFSYVPLPEPVSTDRIKFSANNGDTYEVILCFLNLDKARSISINQRDFDYTPRVDLLVMLTIYMHDMNPVMYLIPSMVFATPNAIFQNHEQPDNLRHFSTWQIKIFTKAIEELSHYALDAVNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS44</accession>
    <name>D7VS44_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpsU</name>
        <name evidence="6" type="ORF">HMPREF0766_13798</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995293.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13798"/>
    <dbReference type="EnsemblBacteria" id="EFK56595">
        <property type="protein sequence ID" value="EFK56595"/>
        <property type="gene ID" value="HMPREF0766_13798"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0828">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159258_2_0_10"/>
    <dbReference type="OrthoDB" id="2088764at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00358">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_S21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018278">
        <property type="entry name" value="Ribosomal_S21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038380">
        <property type="entry name" value="S21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21109">
        <property type="entry name" value="PTHR21109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00976">
        <property type="entry name" value="RIBOSOMALS21"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00030">
        <property type="entry name" value="S21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01181">
        <property type="entry name" value="RIBOSOMAL_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK56595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="63" mass="7480" checksum="D8B9CC78BE35D0C3" modified="2010-10-05" version="1">MIIVNVKEGESLDRALKRFKKKFEKTGVLRELRSRQAFEKKSVTRRIQVKKAIYKQSLNQETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS57</accession>
    <name>D7VS57_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin-like protein</fullName>
            <ecNumber evidence="2">1.6.5.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mdaB</name>
        <name evidence="2" type="ORF">HMPREF0766_13811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.10" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995320.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13811"/>
    <dbReference type="EnsemblBacteria" id="EFK56608">
        <property type="protein sequence ID" value="EFK56608"/>
        <property type="gene ID" value="HMPREF0766_13811"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083846_0_0_10"/>
    <dbReference type="OrthoDB" id="1143659at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008753">
        <property type="term" value="F:NADPH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="204" mass="23662" checksum="B6C725B03DF2BC4A" modified="2010-10-05" version="1">MKKILIINGGQHFGHSGGRFNTTIAATTFDFFNEMEDVEVQLTTIDHGYDAEEEVRKFVWADYIIYHTPIWWFQLPHKFKQYIDEVFTVGHNKGIYHSDGRSSDNPEINYGTGGELAGRKYMLTTSWNAPATAFTLPGEFFQQHSVDEGALFGFHRMNAFVSLEKMESFHFHDVEKNAQVERDMEQYRLHLKNVFAEEFNSVTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS60</accession>
    <name>D7VS60_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995325.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56611">
        <property type="protein sequence ID" value="EFK56611"/>
        <property type="gene ID" value="HMPREF0766_13814"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_10_1_10"/>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="100" mass="11791" checksum="27DE73D2A0907A4B" modified="2010-10-05" version="1">MDYIEIFKALSNKGRFQILQWLKDPEAHFPYQEHADLREIGVCVGQIQRKSGLTQSTVSEYLAIMQKANLVHSVKIGQWIYYKRNEEILQLISNFFKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSH5</accession>
    <name>D7VSH5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG5</name>
        <name evidence="1" type="ORF">HMPREF0766_13929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995581.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13929"/>
    <dbReference type="EnsemblBacteria" id="EFK56726">
        <property type="protein sequence ID" value="EFK56726"/>
        <property type="gene ID" value="HMPREF0766_13929"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_10"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="254" mass="26682" checksum="C51D7C74166177BC" modified="2010-10-05" version="1">MSKLVNKSAIITGGGSGIGKAISLLFAAEGAEVHILDLNTDGADQVVEEITAAGGKAKAHACNVAIQSEVVTVVESIGTVNILVNNAGIAHVGKLEGCTSEDFDRIFNVNVKGAYNALYAAVPLMKKQGGGAILNMASIAAWVGISDRFAYSMSKGAIFAMTLSVARDYMADSIRCNSISPARVHTPFVDGFIAKNYPGQEAEMFEKLSKSQPIGRMAQPEEIAKLALFLCSDDAGFITGNDYPIDGGFIKLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSY1</accession>
    <name>D7VSY1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995876.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14085"/>
    <dbReference type="EnsemblBacteria" id="EFK56882">
        <property type="protein sequence ID" value="EFK56882"/>
        <property type="gene ID" value="HMPREF0766_14085"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9BC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046268_1_0_10"/>
    <dbReference type="OrthoDB" id="366632at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032627">
        <property type="entry name" value="DUF4876"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16215">
        <property type="entry name" value="DUF4876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="427" mass="46407" checksum="B4DC943C4AC6D6C8" modified="2010-10-05" version="1">MKTSVSIPHIKPFSSQADDQKTTYKRMKTKSILILLAVFSIFTACRKDYYAYTTVDYSFTIQYPEEYSKQLADSVKINLKNTITGATQEFVSDAQGRVSAKGITPGVYTVTASKQVTAEEAEQLVGIREEIFCNGSIPTLRITESANSEIRLVGSQAGGFVIKEFYYAGSKTPSGTNYLYDGFIEIYNNSTGDLYADSLVIGNTKSASATVYGFLPDKNNVYLAQAWMIPGNGTQHLVRPGESVVIAITAINHKTDPNGNPNSPANLGKGIADFETYFNPTGTNTRDTDNPDVPNMIHQFANTTAGFDWNIGINGAGLILFRDSQVAGYQTLTEPNVSGTTRYLQVPVKAILDGVDCVGNSTITIDKKRIPETVDAGLTFVGSTYSGKSVIRKVKSRINNRAVLMDSNNSSADFIVNDNPTPKTIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT22</accession>
    <name>D7VT22_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995980.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14126"/>
    <dbReference type="EnsemblBacteria" id="EFK56923">
        <property type="protein sequence ID" value="EFK56923"/>
        <property type="gene ID" value="HMPREF0766_14126"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032PBC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2169475_0_0_10"/>
    <dbReference type="OrthoDB" id="1661436at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="110" mass="12982" checksum="2DDF1AA66AEF75ED" modified="2010-10-05" version="1">MTRSNLHIKLSNGKSLICVADSSSAPEQGYIVERLFLPLLSLDNSEQELEMLTEHCTMDERRINADYRYLIDLTTKEVKFFEEHYSYTKDTFRKGKDITERYDEYLKTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT57</accession>
    <name>D7VT57_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002978454.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14161"/>
    <dbReference type="EnsemblBacteria" id="EFK56958">
        <property type="protein sequence ID" value="EFK56958"/>
        <property type="gene ID" value="HMPREF0766_14161"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_637521_0_0_10"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107267" evidence="2">
        <location>
            <begin position="27"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="427" mass="48627" checksum="AFCAF84FD9D36A9D" modified="2010-10-05" version="1">MIKVIHKQKSKWLIGLLLMCSHWAMAQQNNSLTLDHCLEMAKQNYPLIKQYTLIEKTKEYSIANAQKGVLPQFNIAGQATYQSAVTQVPISLPNVDIPTMSKDQYRLYGEVSQSITDLFTVKDQKEYINANSEIETQKTEVELYKLRERINNLYFGILLIDAQIQQTELLKKDIKSGIEKTNVAIANGVALKSTADNLKAELLKADQRTIELKATRKGYADMLALFIGKSIDENTVLEKPHRQMLTPTINRPELKLYDLQKKSFDVQEKLITAKNLPRLSAFFQGGFGRPGLNMLDNDFQGYYIGGLRLSWNITGFYTYKNEKKMLANNQSLIDIQRETFLFNTNLTLKQQNADITKMQDLIETDKSIVILRESVKNTTQNQLTYGTATTNDYLIAVNAEDQAKQSLILHEIQLLMTEYNAQTTAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTA5</accession>
    <name>D7VTA5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996178.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14209"/>
    <dbReference type="EnsemblBacteria" id="EFK57006">
        <property type="protein sequence ID" value="EFK57006"/>
        <property type="gene ID" value="HMPREF0766_14209"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZAUF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_655130_0_0_10"/>
    <dbReference type="OrthoDB" id="233444at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107368" evidence="1">
        <location>
            <begin position="23"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="420" mass="46134" checksum="C4EEB8AEE634D772" modified="2010-10-05" version="1">MKKYIKLTALFLVMTGFISCEKANIDVDTRPVDGSATGEVSGVWAKGSTQVIKGDIVIPEGQSLTIEEGVTIVMDTIAKPEIIVKGNLYSLGTAENPVKFTISEPYRTEANKFGKLWGGILAAPTCKELVLDYTILEYGGSTTSDASTSVKMGLYKNKPGENLPAIWFSNVNGKLIVQHSIIRHFQEDCTYIDGGKIIFSNNEFYTNGITGGDAMNFKSGSLADVAYNIVYSMNSNALKLSNTGDRTPQAYIIAYNNTMVNTGWRRPTAKGGSVWVEATVRADLYNNLFANTRFGIKRDPKKPEDSRSVYSNNWYYGFDQTTVDQFQPGKNDVIGGVNDVKGTKAGENDPKFVNYPMNTAMTLPDYNKAWDFHLQGNSPALTKGTTAFKRHYKDGIVLENGTRYSSPEPALYVGAYGVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTB5</accession>
    <name>D7VTB5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter, major facilitator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">phnB</name>
        <name evidence="7" type="ORF">HMPREF0766_14219</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996208.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14219"/>
    <dbReference type="EnsemblBacteria" id="EFK57016">
        <property type="protein sequence ID" value="EFK57016"/>
        <property type="gene ID" value="HMPREF0766_14219"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_634501_0_0_10"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="403" mass="44568" checksum="C02841B880574B11" modified="2010-10-05" version="1">MLLITMFCYLFFYTGRHNFGWAAKGMATELNISFQQIGWISFSMLMGYALGQLINGNLADRFSPKIMILTGGFLSIICNLSISYATTYTAILILWTLNGYFQSMAWGSGSKLISNWWDSDERGKAFGFYTMAAGSSSVLTFFMALLLVQQGQSWRTLFRYPILFLLFALVLFLIIARSHPAIKGYTTAANPSSGNIAQKAAWKSSYKTVFQNRNFMIASVAIGFQSMARYGLIFWVPIHFLGNNYKESSDNLWLTLFIPAGMAIGAVSFGYISDVLFNKNRSKSIRIGMLCSCAVALLIYVIPTPHHALAAVLMFAAGFFVYGPQANFWTLSPDLLGSQLVGTGIGIMNMFAYVFAAAGEPLFGKIIDYTGDTSNIFLIVAVICTVCACIISFVKPQQINNHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTD0</accession>
    <name>D7VTD0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alginate regulatory protein AlgP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">algP</name>
        <name evidence="2" type="ORF">HMPREF0766_14234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996255.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57031">
        <property type="protein sequence ID" value="EFK57031"/>
        <property type="gene ID" value="HMPREF0766_14234"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZUCQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_993600_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="280" mass="27376" checksum="5FFF1C3E1427FEB7" modified="2010-10-05" version="1">MAKSKPIKEKKDKKSKDGAPVAKEKKTDKKKPDAKKEKPKKAKVKKVKKASKGKKDSKLEKAYKKLSKEVKTLVGKLKTNVESVVEKVIPEKTEEKAKVQTKAAKPAAASSAAKPASTKATPAKTSTSSAAKPAAAKAAPAKPAAASSAAKPASTKATPAKTSTSSAAKPAAAKAAPAKPAATSSAAKPAAAKAAPAKATAASSAAKPAAAKAAPAKPAATSSAAKPAAAKAAPAKTTAASSAAKPAAAKATPAKTTAASSAAKPAAAPTATPDTDKKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTE4</accession>
    <name>D7VTE4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14248"/>
    <dbReference type="EnsemblBacteria" id="EFK57045">
        <property type="protein sequence ID" value="EFK57045"/>
        <property type="gene ID" value="HMPREF0766_14248"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2013804_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="123" mass="13677" checksum="53D2E0DC66595837" modified="2010-10-05" version="1">MHGNRKYYSSNLFGSPPQKKSHQITEPATHVLFKTQLQTSGHHLRTRSGNQLHEAQSAAQQANQAKILATQAKTANHTASTANQKLGRHPQIYPTAAYRQNSSLYGTESNHCHPTKAKRKPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTI0</accession>
    <name>D7VTI0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipocalin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">blc</name>
        <name evidence="4" type="ORF">HMPREF0766_14284</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996383.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14284"/>
    <dbReference type="EnsemblBacteria" id="EFK57081">
        <property type="protein sequence ID" value="EFK57081"/>
        <property type="gene ID" value="HMPREF0766_14284"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068449_3_0_10"/>
    <dbReference type="OrthoDB" id="1770932at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022271">
        <property type="entry name" value="Lipocalin_ApoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002446">
        <property type="entry name" value="Lipocalin_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08212">
        <property type="entry name" value="Lipocalin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036893">
        <property type="entry name" value="Lipocalin_ApoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01171">
        <property type="entry name" value="BCTLIPOCALIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocln_cytosolic_FA-bd_dom" evidence="3">
        <location>
            <begin position="37"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR036893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="177" mass="20466" checksum="F799054B2CCC2669" modified="2010-10-05" version="1">MDKKKSLLLLSATAVGTLLYQALKPVKSDIRGVSNFNLDSYLGQWYEIARLDFRWEKNLKNVTANYSLNEDGSIQVVNEGYDMRKQKQKKSIGKAKFMRDHSEGAFKVSFFPPFSAGYHVMKIDPDYKYALVFGDNLNYMWILSREKSIPGDIKSIYLDFALRSGFEIHKLVWTIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTJ0</accession>
    <name>D7VTJ0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996394.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14294"/>
    <dbReference type="EnsemblBacteria" id="EFK57091">
        <property type="protein sequence ID" value="EFK57091"/>
        <property type="gene ID" value="HMPREF0766_14294"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1146612_0_0_10"/>
    <dbReference type="OrthoDB" id="2166481at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="242" mass="28413" checksum="E8B556E68170324D" modified="2010-10-05" version="1">MQMIFIIVGVMIITLVFLWKISGLGVKEETVAGDFYKANRDFLYSEKRELYIKKMIRRYQQLKWIITIIVLIIAFIPFFITVSDTLSFNGRLDAERYDARMRDSYILLVCMLGIGLLTCFFSWMIFKKTVQNYTKVIMELDNAHFEKMISVNNHLGLVNQFMMNAPFIIGYSNLYVFKLARILVLPWSEIKSIKITSAPRNGYYVRVKIKEKTYFFTVGEPQIVVILETEALKYNPDIEVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTJ1</accession>
    <name>D7VTJ1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996396.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14295"/>
    <dbReference type="EnsemblBacteria" id="EFK57092">
        <property type="protein sequence ID" value="EFK57092"/>
        <property type="gene ID" value="HMPREF0766_14295"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2289876_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="101" mass="11851" checksum="37BDC1BAF715AD38" modified="2010-10-05" version="1">MKYIGIRVILLLLLLVVIYYMSDYIQEYTVVDDGDYNFEGVIAFFQMTLGLAIISLGLFIYEACRFNKRKEHKKRNASLILISLILIVLILFAGYFFEFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTW3</accession>
    <name>D7VTW3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA gyrase subunit B</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">gyrB</name>
        <name evidence="12" type="ORF">HMPREF0766_14433</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002279.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14433"/>
    <dbReference type="EnsemblBacteria" id="EFK55742">
        <property type="protein sequence ID" value="EFK55742"/>
        <property type="gene ID" value="HMPREF0766_14433"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006146_1_2_10"/>
    <dbReference type="OrthoDB" id="205481at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="429"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK55742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="652" mass="72649" checksum="6C865C3AF0EF07C2" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGC4</accession>
    <name>D7VGC4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0766_10043</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10043"/>
    <dbReference type="EnsemblBacteria" id="EFK60099">
        <property type="protein sequence ID" value="EFK60099"/>
        <property type="gene ID" value="HMPREF0766_10043"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="49"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="364"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="397"/>
            <end position="404"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK60099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="606" mass="68325" checksum="2A4F2A441B3F8004" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGJ9</accession>
    <name>D7VGJ9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0766_10118</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996621.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10118"/>
    <dbReference type="EnsemblBacteria" id="EFK59201">
        <property type="protein sequence ID" value="EFK59201"/>
        <property type="gene ID" value="HMPREF0766_10118"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065795_0_0_10"/>
    <dbReference type="OrthoDB" id="2074833at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TonB_C" evidence="10">
        <location>
            <begin position="213"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK59201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="293" mass="32151" checksum="7CE24F873D35050F" modified="2010-10-05" version="1">MLGSKLNIYKKEWLEVIFQGRNQSYGAYELRQLSPRATNYGLAIVTTFVLLCSMGKFAYDHMPGEQYVAPVMEVTPVTLDDLVEKIPEEKIEDPLPAENQPKQIAQDPPALDLIRFPEPTVVDARKAKDDVATQDDFKDDKKSPARLTLKAMPGGSAIARGEFGDKKKDGEITGKGTGTLSGGDDKIHDMVALEIQPEPIGGIKAFMKWVGDNYQYPSAALEQGVNGVVMVSFVIEKDGSLTDIKVGRDLNFGTGDAAVTLLKKARKWSPGIQNGRPVRVAYSLPIRLNTIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGL1</accession>
    <name>D7VGL1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LptD_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996658.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10130"/>
    <dbReference type="EnsemblBacteria" id="EFK59213">
        <property type="protein sequence ID" value="EFK59213"/>
        <property type="gene ID" value="HMPREF0766_10130"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007637_0_0_10"/>
    <dbReference type="OrthoDB" id="100018at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045659">
        <property type="entry name" value="LptD_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19838">
        <property type="entry name" value="LptD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LptD_2" evidence="1">
        <location>
            <begin position="202"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="861" mass="96793" checksum="3B4ADD84591F0B5D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGP2</accession>
    <name>D7VGP2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996763.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10161"/>
    <dbReference type="EnsemblBacteria" id="EFK59244">
        <property type="protein sequence ID" value="EFK59244"/>
        <property type="gene ID" value="HMPREF0766_10161"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_841746_0_0_10"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="227"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="330" mass="37953" checksum="3E9CE88A0C0DB19D" modified="2010-10-05" version="1">MRHIKHSYSLSPDWMYQVAHAFDTEVIDNKRSELPHQHGTGGTIFLEITSGFSVQLVDLIYTVPIKVTRTPTKEDMYVVYYDISDHYNQHIINGTDHKVGYSSKFGMGFTDGKVESTFIPAIGERNFYLRLFIAKSLLHSMLSDCKPTEAVEVIFDKSKKVLSYYQHMESATQVLLNELKNRSFDDPAFELFLKGASLQIFTNLVRRIRLYDDTLYKLPQQDLDSMDKSIAYMTNDLQMDFPGIHKLAEIAGMSTSKYKTLFKKIMKDTPQQFFLNEKLLLAKELLNGGMFRSIKEVALELGYSQSGYFAAAYRKKFNLLPGENFIKPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGQ5</accession>
    <name>D7VGQ5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacteroidetes fimbrillin superfamily. FimB/Mfa2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10174"/>
    <dbReference type="EnsemblBacteria" id="EFK59257">
        <property type="protein sequence ID" value="EFK59257"/>
        <property type="gene ID" value="HMPREF0766_10174"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50308JW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_482884_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14948">
        <property type="entry name" value="BACON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024361">
        <property type="entry name" value="BACON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014941">
        <property type="entry name" value="FimB/Mfa2/Mfa3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08842">
        <property type="entry name" value="Mfa2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="473" mass="51481" checksum="FEDD1F204A89C78A" modified="2010-10-05" version="1">MERIRLPILLIMCIYTVTLISCIKEKTIIDDTNTETNGTKEVSFTASMPGLSQNISTYAISDNEENKVTTIDILVFEMTGSTEKYAYRVAGRNIRPLTANSIQFQATLQAHATKKYRLVAIANARTTVNAASYTVGALKSDILKNLVINKPGVWNTTSSADYSPLPMSGESEPNLSINSNTGSITLNMIRIQARVDVIVEPTLITRFQMTSISVYNSNSNARIAPSATTTGSNGPIVTAPSLPASPQINSSPLVYIPDPVTPPNTVNSRQQIYLFEKNAAASAGASGALSLIIGGYYDGSSTETYYKLEFLSKEAAPIPLAVLRNHKYEFKIKEVSGAGYPTKEAALTGKPSNIQGSVVTLNLSDMPIIYFDEHYYLAMETDLVNYPTNQAKGQFYKIKTDFPGGWTWTSDQPSWLSMNPYNNGTSDGANISVEINQGNPVPRHGILTITAGKIRARIKVYQGYGTNPLPIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGQ6</accession>
    <name>D7VGQ6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK59258">
        <property type="protein sequence ID" value="EFK59258"/>
        <property type="gene ID" value="HMPREF0766_10175"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2652619_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="76" mass="8435" checksum="BAE8E5250ED4CCE8" modified="2010-10-05" version="1">MVGIVFLSISGYTESQYIQTVDAVLIDLADGLGTGFITGLWQYQTQGYLLFTRLGLFLRNTCLFTACQGSKNEEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGX8</accession>
    <name>D7VGX8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996982.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10247"/>
    <dbReference type="EnsemblBacteria" id="EFK59330">
        <property type="protein sequence ID" value="EFK59330"/>
        <property type="gene ID" value="HMPREF0766_10247"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZBQZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105419_0_0_10"/>
    <dbReference type="OrthoDB" id="1436985at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="150" mass="16862" checksum="F80F26F6A5B83D80" modified="2010-10-05" version="1">MRVWVYQASRKLTAGEQAFAADKLAAFISVWNTHGKSLAADVEIRHGLFIILKVDESRVAASGCSIDSSVHFLKGLQQELGVDLFDRFQLAYRTTEDIAVVGRQEFEQLVASGQINSSTIVFNNLISNEDELLNKWEVPFKDSWHARVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH02</accession>
    <name>D7VH02_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HGSNAT_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997054.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10271"/>
    <dbReference type="EnsemblBacteria" id="EFK59354">
        <property type="protein sequence ID" value="EFK59354"/>
        <property type="gene ID" value="HMPREF0766_10271"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4299">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029171_4_0_10"/>
    <dbReference type="OrthoDB" id="768508at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012429">
        <property type="entry name" value="HGSNAT_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07786">
        <property type="entry name" value="HGSNAT_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="HGSNAT_cat" evidence="2">
        <location>
            <begin position="4"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="404" mass="45844" checksum="A79037DEA1222996" modified="2010-10-05" version="1">MKQRYYSLDVFRGATVALMIMVNNPGSWGHMFAPLKHAEWHGCTPTDLVFPFFLFAVGNAMSFVIPRLQEAGPAVFWQKVLKRTVLIFLIGLFINWWPFVQWAQDTLVFKQWSYADDSMRGVRILGVLQRIALAYCFASIIAYYFREKAIIWISTFILVVYWAVCAFLGTPGDPYSLQGWFGTAYDIQILGVAHVYKGEGVPFDPEGLMSTLPAIVQVVLGYLAGTYIKKQGQVDWLWKKVPASQEPHFKLLSGLFVTGFILVVLAWVWSLGFPINKKIWTSSYVLYTTGLGVMTIGGMIWFIEVQGVKNSLTRFFDVFGKNPLFIFVLSGLLPRLVGLWRIPDGVGEDGLPVYTNALNWFYTHICAQLPGPPEVGSFAYSLCFLAFMWVICYILDKKKIYIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH65</accession>
    <name>D7VH65_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997190.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10334"/>
    <dbReference type="EnsemblBacteria" id="EFK59417">
        <property type="protein sequence ID" value="EFK59417"/>
        <property type="gene ID" value="HMPREF0766_10334"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033XK9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1884446_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106938" evidence="3">
        <location>
            <begin position="27"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="113" mass="11934" checksum="922CEC1F662271C1" modified="2010-10-05" version="1">MKNKNGILAFALLGLAAGTAAYYLLATEDGKKQMDRANDGIKSLTKSLKDLSKKEAKRASKFAQSAKDEIMELKGKAKDLGKDLAEKASSAAHSMANKVDEGASKAKSSIDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHA0</accession>
    <name>D7VHA0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Biopterin-dependent aromatic amino acid hydroxylase</fullName>
            <ecNumber evidence="8">1.14.16.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pah</name>
        <name evidence="8" type="ORF">HMPREF0766_10369</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.16.1" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997265.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10369"/>
    <dbReference type="EnsemblBacteria" id="EFK59452">
        <property type="protein sequence ID" value="EFK59452"/>
        <property type="gene ID" value="HMPREF0766_10369"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034458_0_0_10"/>
    <dbReference type="OrthoDB" id="292455at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004505">
        <property type="term" value="F:phenylalanine 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="PTHR11473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="SSF56534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BH4_AAA_HYDROXYL_2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="588" mass="66012" checksum="C2638E32352EBB2B" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHA5</accession>
    <name>D7VHA5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucyl/phenylalanyl-tRNA--protein transferase</fullName>
            <ecNumber evidence="4">2.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L/F-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Leucyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phenyalanyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">aat</name>
        <name evidence="5" type="ORF">HMPREF0766_10374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:50416"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12673"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64719"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:133044"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] = H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:12340"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12670"/>
            <dbReference type="Rhea" id="RHEA-COMP:12671"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:65249"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:133043"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) = an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:43632"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="Rhea" id="RHEA-COMP:10636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10637"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:83561"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the L/F-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.6" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997276.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10374"/>
    <dbReference type="EnsemblBacteria" id="EFK59457">
        <property type="protein sequence ID" value="EFK59457"/>
        <property type="gene ID" value="HMPREF0766_10374"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075045_0_0_10"/>
    <dbReference type="OrthoDB" id="1670846at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008914">
        <property type="term" value="F:leucyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00688">
        <property type="entry name" value="Leu_Phe_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004616">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042203">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042221">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30098">
        <property type="entry name" value="PTHR30098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03588">
        <property type="entry name" value="Leu_Phe_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00667">
        <property type="entry name" value="aat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="210" mass="24016" checksum="E552574AA4165849" modified="2010-10-05" version="1">MIFQLDDQDLSFPHPKYAEEDGLLAVGGDLSPDRLLLAYNNGIFPWFSDDSPILWYAPHERFVIFPERLKVSKSMKQVLRKAEFKVTVNTVFEQVIRQCAKIERKDQDGTWITNDMIDAYIGLHKSGYAHAIEVWQEDQLVGGLYGVLIGQVFCGESMFSKVPNASKTALIHLFQFFDLKFVDCQFHTDHLASMGGEMISQEDYLNILNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHC2</accession>
    <name>D7VHC2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_10391</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997313.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10391"/>
    <dbReference type="EnsemblBacteria" id="EFK59474">
        <property type="protein sequence ID" value="EFK59474"/>
        <property type="gene ID" value="HMPREF0766_10391"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_2_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106942" evidence="5">
        <location>
            <begin position="30"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="127"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="423"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1029" mass="112559" checksum="BD3DD6FE1609F7B3" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHD6</accession>
    <name>D7VHD6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-specific adenosine deaminase</fullName>
            <ecNumber evidence="1">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">tadA</name>
        <name evidence="3" type="ORF">HMPREF0766_10405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997354.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10405"/>
    <dbReference type="EnsemblBacteria" id="EFK59488">
        <property type="protein sequence ID" value="EFK59488"/>
        <property type="gene ID" value="HMPREF0766_10405"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0590">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025810_3_2_10"/>
    <dbReference type="OrthoDB" id="1890883at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00972">
        <property type="entry name" value="tRNA_aden_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="154" mass="17244" checksum="C5B0634E2D40161D" modified="2010-10-05" version="1">MRYINFEESSNIDPDEFYMKAALTLAKKAYEEDEVPIGAVIVSQGKIIGKGYNLTERLNDVTAHAEMQAFTAASSYLGGKYLKDCTLYVTVEPCVMCAGASYWTQVSRIVYGAPDEKRGASRYGKLFHPKTEIISGVLQEECAELITSFFRQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHE2</accession>
    <name>D7VHE2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Succinate dehydrogenase/fumarate reductase iron-sulfur subunit</fullName>
            <ecNumber evidence="4">1.3.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">frdB</name>
        <name evidence="4" type="ORF">HMPREF0766_10411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.1" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10411"/>
    <dbReference type="EnsemblBacteria" id="EFK59494">
        <property type="protein sequence ID" value="EFK59494"/>
        <property type="gene ID" value="HMPREF0766_10411"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044838_3_3_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="257" mass="28370" checksum="AC8E5E5142B9BA43" modified="2010-10-05" version="1">MSAHMNLTLKVWRQKNDKQKGQFVTYQANNIADDMSFLEMLDIVNEELTRKGEDPIYFDHDCREGICGMCSLVINGRPHGPKQGTTTCQLHMRSFHDGQTIVIEPWRAAAFPVLKDLAVDRTAFDRIQQAGGYVNVNTGGVPDANAILIPKRIADEAFESATCIGCGACVAACKNASAMLFVSAKVSQFALLPQGQTERYERAQAMVDQMDAEGFGNCTNTGACEAECPVGIKLTNIARLNREYLTAKLFREEDIHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHL6</accession>
    <name>D7VHL6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10485"/>
    <dbReference type="EnsemblBacteria" id="EFK59568">
        <property type="protein sequence ID" value="EFK59568"/>
        <property type="gene ID" value="HMPREF0766_10485"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3296710_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="40" mass="4544" checksum="E766B0396FB37895" modified="2010-10-05" version="1">MGIKKDRLNSVQPVCFKSVVSLLSGDFHVIRKLNLNYKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHS9</accession>
    <name>D7VHS9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Redoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_10548</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997693.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10548"/>
    <dbReference type="EnsemblBacteria" id="EFK59631">
        <property type="protein sequence ID" value="EFK59631"/>
        <property type="gene ID" value="HMPREF0766_10548"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_11_3_10"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="23"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="166" mass="19550" checksum="D2F947991D92B149" modified="2010-10-05" version="1">MKQLILLLILTIAVPVFGQEWKVKVGEQTPVFEWKDKKEERKDISMLKGKVVLINFFATWCPPCRQELPRVENEIWAKYKSRTDFSLLVFAREEGWDKLNPFMSKQQYTFPVFPDLKREIFSKYADTGIPRNVILNKKGEVVYQSIGYTEDEFKHLLTVLESELAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHT9</accession>
    <name>D7VHT9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase, C39 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997723.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK59641">
        <property type="protein sequence ID" value="EFK59641"/>
        <property type="gene ID" value="HMPREF0766_10558"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1728071_0_0_10"/>
    <dbReference type="OrthoDB" id="1536122at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005074">
        <property type="entry name" value="Peptidase_C39"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03412">
        <property type="entry name" value="Peptidase_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C39" evidence="1">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="134" mass="15872" checksum="2FDA466EE995A59A" modified="2010-10-05" version="1">MKVKHVYQHDNTGCGIACIAMLANQTYHEMKELLIYKGLLSDNTEFFGTTFRQLTNILTSFNFRSMPRRKFKKWSNIPAKIAIASTNYDNSGSWHWVIFVRDIDGFYIYDPCKRRKKIRDLRGKMSGWFIEILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI86</accession>
    <name>D7VI86_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rfbD</name>
        <name evidence="4" type="ORF">HMPREF0766_10705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998041.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10705"/>
    <dbReference type="EnsemblBacteria" id="EFK59788">
        <property type="protein sequence ID" value="EFK59788"/>
        <property type="gene ID" value="HMPREF0766_10705"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045518_1_2_10"/>
    <dbReference type="OrthoDB" id="1076083at2"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="286" mass="32155" checksum="1E28E4B963E0839A" modified="2010-10-05" version="1">MKILITGANGQLGSELREIYNERQDVETFFLDRKQLPLEQTMLIQNILAMYEPDLIIHAAAYTAVDLAESEPELADAINHLASEQIAEYCAIHGTRLIAISTDYVFDGKSAVALSEDSSVGPISVYGKTKLKGEQIIQRLCPDAIIIRTSWVYSVYGKNFVKTMIRLMTEREEIGVVSDQIGSPTAAKDLASAIVHIIDAAKWEGGIYHYSNDGEISWYDFALAIKDFNRLSCNIRAISTNNYPTPAQRPQFSLLDKSKIKRIFGVNVPYWKDSLRQTLMQLNEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI94</accession>
    <name>D7VI94_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide sugar dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">wbpO2</name>
        <name evidence="5" type="ORF">HMPREF0766_10713</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10713"/>
    <dbReference type="EnsemblBacteria" id="EFK59796">
        <property type="protein sequence ID" value="EFK59796"/>
        <property type="gene ID" value="HMPREF0766_10713"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_3_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="327"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="432" mass="48082" checksum="86F0AEAE289EC530" modified="2010-10-05" version="1">MDMQDSMNIAVIGQGYVGLPLALAFSKYHQVTGFDINETRVAELNSGYDRTLEISKEELLALINREESSSITGYVASSDLTDIRDAQVYIITVPTPVDAFNTPNLQPLLSATRLVSSVLKRGDIVIYESTVYPGCTEEECVPLLERESGLTFNRDFFVGYSPERINPGDKINTLSSVVKVTSGSTPEIADVIDQLYKQIITAGTHLAPSIKVAEASKAIENAQRDVNISFVNELALIFDRMGIDTNEVLEAAGTKYNFLKYKPGLVGGHCISVDPYYLTYKATRLGYHPQVILSGRQVNNMIATFIAKKLIKLMISRETALMGARVLILGVTFKENCADYRNTKVMDIIRELQDFGLTVDVYDPWVDEEAFEKEHNIRILKELPSLVFYDGAVLAVAHHQFGEIEPRSLVKENGVIFDAKGFWDKQSVDARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIC2</accession>
    <name>D7VIC2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Antioxidant, AhpC/TSA family</fullName>
            <ecNumber evidence="5">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ccmG2</name>
        <name evidence="5" type="ORF">HMPREF0766_10741</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.15" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998111.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10741"/>
    <dbReference type="EnsemblBacteria" id="EFK59824">
        <property type="protein sequence ID" value="EFK59824"/>
        <property type="gene ID" value="HMPREF0766_10741"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_1_0_10"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025380">
        <property type="entry name" value="DUF4369"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14289">
        <property type="entry name" value="DUF4369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106984" evidence="3">
        <location>
            <begin position="19"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="235"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="376" mass="41313" checksum="7B134ED6C06AEF96" modified="2010-10-05" version="1">MKKSIFLGLSLIPALVFAQEDFTVHGKLANVGDKAKAYIQYRDNGQAFLDSTAVVKGEFKFHGTVTEPVQAFVVLSPEGLDPQSIPQPDLTAVYLSKGVVKIEGDKILKDAKISGNQINDNLVAYKQVIKPFEEQFAALNNEYMAATAEQKNDQEFVGALQEKAQAIFEKQQVVNDEYVKANPNSFISLSLLEEKLDPESVSEFVEPQFKSLSAELKNSKKGKALEQKIADLKKLAVGSVAPDFTLPDTTGKPLALSSLRGKYVLVDFWASWCGPCRHENPNVVAAFNQFKDKNFTVLGVSLDQEGKKDAWVNAIKADNLQAWPHVSDLKGWGSAVVELYSIRGIPQNFLLDPQGKIVASNLRGEALVAKLSEILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIF4</accession>
    <name>D7VIF4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, group 1 family protein</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998174.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10773"/>
    <dbReference type="EnsemblBacteria" id="EFK59856">
        <property type="protein sequence ID" value="EFK59856"/>
        <property type="gene ID" value="HMPREF0766_10773"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_14_4_10"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="175"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="402" mass="45081" checksum="FCBAB3753B251E95" modified="2010-10-05" version="1">MRTAIIGTYPPRQCGIATFTQDLYKAMLKSSAEIHSIFAMSDGSEESFPDEVAFVIDRNDVNSYKHAAHLINSYYDACIIQHEYGIFGGDTGEFILELLYKLQVPVVTNLHTVLQQPSPNEQHILQQLSMYSSKITVMTERAIQMLGDVYKVDTQLVELIPHGVPDFKYDQEAAKTKLGLCDKKVMLSFGFLGRSKGFETAIDAVASVKDNDFKYIILGSTHPNIIRHEGEIYRESLMDKVKELGIEDKVEFVDTFATEELLVQYLSACDIYVTPYPNENQISSGTLSFAIGAGAAVLSTPYWYAKDLLANDRGILFDFKDSDGLATIINLLLEEPLLMARYRSNAKQYGQEMSWTNIGKRHVALLESFKKTDIKPTISFNSRNLKKNIAALFPTGNSRLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIF9</accession>
    <name>D7VIF9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF892 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998184.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK59861">
        <property type="protein sequence ID" value="EFK59861"/>
        <property type="gene ID" value="HMPREF0766_10778"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3685">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102561_2_0_10"/>
    <dbReference type="OrthoDB" id="1739824at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010287">
        <property type="entry name" value="DUF892"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05974">
        <property type="entry name" value="DUF892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF892" evidence="2">
        <location>
            <begin position="37"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="193" mass="20963" checksum="F93774F2BE1DA0A7" modified="2010-10-05" version="1">MATTSAKSSSASKTAPAKSSNKEDSKIKAKSGAAKDLADLFEDGLKDIYWAEKELTKALPKMDKNATSPQLKKAIQKHIKETEEHISRLEKCFETLGKKAKAEKCDAMAGLIEEGESIMEETEVGHVRDAGIIAAAQKVEHYEIATYGTLAAFAKVLGNKESLKLLLMTLEEEKNCDETLTGIADTNLNSKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VII5</accession>
    <name>D7VII5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PepSY domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998234.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10804"/>
    <dbReference type="EnsemblBacteria" id="EFK59887">
        <property type="protein sequence ID" value="EFK59887"/>
        <property type="gene ID" value="HMPREF0766_10804"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031962_2_0_10"/>
    <dbReference type="OrthoDB" id="1656356at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005625">
        <property type="entry name" value="PepSY-ass_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34219">
        <property type="entry name" value="PTHR34219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03929">
        <property type="entry name" value="PepSY_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="465" mass="52670" checksum="64656463DF5910BA" modified="2010-10-05" version="1">MNKSKQITADSKWPKIRKFFNDLHLWFGLISGIVVLIVCLTGTIYVYNTEIREAAAPHLFKVEKTSREAMTADDLLVAAKKQIKGKISGIRISEDPERAYAILYSKPKKEEGKPEGEGKSEKKPEKPESKNERKESLAENGEGKNKKEGQQKEKKAGPPAGGRQRANQMMINPYTGELLGDPQEKETKTAAFMQKMFSLHRWLMLNEIEKPLIEGVENRKLGSWITGTATLLFTLGVISGIIIWFPQRLRGWKNGLKIKWSGKWKRINHDLHNTLGFYSCIILFLMGVTGPFWSFDWYRTGWQKTWGTYKEAPKEGAAPPKEEKKEESIYPGPEHAPLRVNQLLAIADKEFVYPGDYMVSLASDSVATVSISKYKKGFFAPSTADRLILDQYSGKILKKEIFAEKPLNERISSSVKSLHVGDVYGPFTKLLYFISCLIATSLPVTGVMIWLNKMKKTKKKKPEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VII8</accession>
    <name>D7VII8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998240.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10807"/>
    <dbReference type="EnsemblBacteria" id="EFK59890">
        <property type="protein sequence ID" value="EFK59890"/>
        <property type="gene ID" value="HMPREF0766_10807"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052345_4_0_10"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="182"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="297" mass="34399" checksum="8B77AF6E96F0F1AB" modified="2010-10-05" version="1">MKLLNTKTRTLNYDHQDYGIRLINPYTPYELIPEHEGYLVVIAIKEGCSISAGNHKLILKERDSTIIRLDDTHIKVSSRHPDAQCLTLLYKPSYLKHMDITDQSILHIDAGIRKVGKMESEVASRTYIKAVDLIRVQATHTLLPAFYKSKSLYILSSLMDGIQRTVLSKPAELREADIEKIKKVKYIIETNLNKNFTIQHLAREVGTNVQYLKQHFKQYYGKTIFSFISECKMQKAQHLLKERELTISFISHQLGYKHASHFTNAFKKFFGYVPNTIRYSLILFYNEIISITELGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIJ1</accession>
    <name>D7VIJ1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10810"/>
    <dbReference type="EnsemblBacteria" id="EFK59893">
        <property type="protein sequence ID" value="EFK59893"/>
        <property type="gene ID" value="HMPREF0766_10810"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015931_0_0_10"/>
    <dbReference type="OrthoDB" id="929228at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043741">
        <property type="entry name" value="DUF5686"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18939">
        <property type="entry name" value="DUF5686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="871" mass="100290" checksum="EFE548DB6246B211" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIP8</accession>
    <name>D7VIP8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RHS repeat-associated core domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10867"/>
    <dbReference type="EnsemblBacteria" id="EFK59950">
        <property type="protein sequence ID" value="EFK59950"/>
        <property type="gene ID" value="HMPREF0766_10867"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004466_0_0_10"/>
    <dbReference type="OrthoDB" id="1639867at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045619">
        <property type="entry name" value="DUF6443"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20041">
        <property type="entry name" value="DUF6443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107192" evidence="1">
        <location>
            <begin position="21"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6443" evidence="2">
        <location>
            <begin position="109"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1172" mass="128578" checksum="9664C11F9BD5BFFF" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIS5</accession>
    <name>D7VIS5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998422.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10894"/>
    <dbReference type="EnsemblBacteria" id="EFK59977">
        <property type="protein sequence ID" value="EFK59977"/>
        <property type="gene ID" value="HMPREF0766_10894"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032RYR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116315_0_0_10"/>
    <dbReference type="OrthoDB" id="1972825at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="PTHR35519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="161" mass="18528" checksum="89F40F71A152F2D9" modified="2010-10-05" version="1">MPKILLPEEKELRLKQDFAWVERVSWILDNKFNIGGVRFGLDPLLNLIPFAGNLVTFSTSLMLVMVMWRNGVSSKAVVKMLINIMIDAILGAIPFLGNIFDFFKKSNQRNVEILREHYYEGKHQGSGVWLVAAVLGILLLICGIMIFILWKLTEWIYQLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ01</accession>
    <name>D7VJ01_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Antioxidant, AhpC/TSA family</fullName>
            <ecNumber evidence="6">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsaA</name>
        <name evidence="6" type="ORF">HMPREF0766_10970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.15" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998573.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10970"/>
    <dbReference type="EnsemblBacteria" id="EFK60053">
        <property type="protein sequence ID" value="EFK60053"/>
        <property type="gene ID" value="HMPREF0766_10970"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_21_1_10"/>
    <dbReference type="OrthoDB" id="892697at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="2"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK60053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="211" mass="23519" checksum="80C4D4A4D09C3935" modified="2010-10-05" version="1">MSFTGKNFPSIAVDAIDSLGDNLSINIFEKATQEGKKVLLFWYPKDFTFVCPTELHAFQDALPEFEKRNTIVIGASCDSNEVHFAWLNTAKDNGGIEGVTYPILADTNRNLSSILGILEIKEVEHPEYGTLAEGSAVSYRATYLIDETGKVFHESVNDMPLGRNVKEYIRLIDAYTHVQQHGEVCPANWEEGKEAMHATRTGVAEYLSNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ35</accession>
    <name>D7VJ35_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nagZ5</name>
        <name evidence="7" type="ORF">HMPREF0766_11004</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11004"/>
    <dbReference type="EnsemblBacteria" id="EFK59170">
        <property type="protein sequence ID" value="EFK59170"/>
        <property type="gene ID" value="HMPREF0766_11004"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007082_5_0_10"/>
    <dbReference type="OrthoDB" id="727559at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026876">
        <property type="entry name" value="Fn3_assoc_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13287">
        <property type="entry name" value="Fn3_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20b" evidence="6">
        <location>
            <begin position="70"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="5">
        <location>
            <begin position="207"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="680" mass="77642" checksum="5B825761484D1F33" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ61</accession>
    <name>D7VJ61_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000376.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11030"/>
    <dbReference type="EnsemblBacteria" id="EFK58914">
        <property type="protein sequence ID" value="EFK58914"/>
        <property type="gene ID" value="HMPREF0766_11030"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_7_10"/>
    <dbReference type="OrthoDB" id="1785082at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009594">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06719">
        <property type="entry name" value="AraC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="202"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="300" mass="35100" checksum="DBD98E2ABB204013" modified="2010-10-05" version="1">MKHLLNHLPFTDKKEITTLVENRRAFTLNNFELNVYETYQESKLVPLKFNDLVIINMLKGKKVMHLFDRPHFDYLPGETIVVPPSLSMKIDFPEAKESDPTQCTALAIGHQKIQETINYLNEYFPRQYGEQEWRFHYDQYHFYNNAELAYLTNKLFDISLSKELHKDVLADLTLKELLIRIMQTQNLLVVDGPVLSSNNRLQAVTEFIQNNIHENITVEHLSKKANMSKPSFYRTFKEETGISPMEYVIRERIKNAKKVLQNSKSIKEACYASGFSNINYFVRMFKKQEGITPGVFLTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJF1</accession>
    <name>D7VJF1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmA</name>
        <name evidence="6" type="synonym">ksgA</name>
        <name evidence="9" type="ORF">HMPREF0766_11120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000607.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11120"/>
    <dbReference type="EnsemblBacteria" id="EFK59004">
        <property type="protein sequence ID" value="EFK59004"/>
        <property type="gene ID" value="HMPREF0766_11120"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041220_0_1_10"/>
    <dbReference type="OrthoDB" id="2030110at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="8">
        <location>
            <begin position="20"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="259" mass="29502" checksum="398723A1691F9742" modified="2010-10-05" version="1">MSTVRAKKHLGQHFLNDKNAAQKIVDALDPKLGFSQVLEVGPGMGVLSDFLLQKPEYQTYLIDVDDESIEFLADKYPELGDRLIHGDFLALDFSKYFGPKMAVIGNFPYNISSQILFKILDERQRVVQMTGMFQKEVAERCTAKAGSKEYGILSVFLQAYYHVEYLFTVKAGAFTPPPKVLSGVIRMTRNEREELDCDEKLFWRVVKAGFNQRRKTLRNSLSGVVPKDKMSDNPLYELRAERLSVEDFVQLTNEISAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJH1</accession>
    <name>D7VJH1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PPIC-type PPIASE domain protein</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000644.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11140"/>
    <dbReference type="EnsemblBacteria" id="EFK59024">
        <property type="protein sequence ID" value="EFK59024"/>
        <property type="gene ID" value="HMPREF0766_11140"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034646_13_0_10"/>
    <dbReference type="OrthoDB" id="1838755at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="2">
        <location>
            <begin position="176"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="2">
        <location>
            <begin position="274"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="458" mass="52087" checksum="01DD12717AC50DD2" modified="2010-10-05" version="1">MIKQLYVLLFCVLGSVNLTFAQGKIVDRVVATVGANIILQSDIDMQYSQNLAQGMSPNEDFKCYILQQLLTQKLLAQQAVLDSIEVSESEVDDNLNNRLNVMTRQAGGKERLESFLNRSLLQYKEEMRTSVAEQLKAQKMQQNIVQKIDVTPLEVKRYFEGLNKDSLPYFDTEVEIGEIVMYPVLTKEEKEASRKRAEDLRKQIVDGSDFGTIARLYSEDKGSAVAGGDLGFSTRDNYVKEFSAVAFKLKPGEISQVFETEYGFHFLQVLERRGEEVRARHILVSIKPTNASLERTKVKMDSLYQKLINKKIDFYTAATQYSDNKETKFNGGMVTDQNRSTLIPVNKLEASVFTAIDPLKAGEYSQPTLFQEEGPAGKSGYRISFLKTRIPPHKANLDQDFSKIKEAASEDKTRRKLSEWFESRRTNTFIAINEDFHKCDDLKIWIKPIENASANIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJM8</accession>
    <name>D7VJM8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate kinase, FGGY family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000753.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11197"/>
    <dbReference type="EnsemblBacteria" id="EFK59081">
        <property type="protein sequence ID" value="EFK59081"/>
        <property type="gene ID" value="HMPREF0766_11197"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034535_0_0_10"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="457" mass="52345" checksum="6BFD929118DF8025" modified="2010-10-05" version="1">MKPIPVIAVFDVGKTNKKLFLFDENYRIVFERSARFLETEDEDGDPCENLESLRLAVFDSLHEVFRKPQFEVKAINFSSYGASFVYLDEDGRPLTPLYNYLKDYPDALAQKIYDQYGGEETFSKETASPALGSLNSGLQLYRIKEEKPGIFKKIKYALHLPQYLSFLLSGQYYADRTSIGCHTTLWNFKDNGYHRWVSRDGVIDKMAPICNSDEVFKSAFPGSPYVIGTGLHDSSAALIPYLFNFQDPFILISTGTWSISFNPFNHSELTLEELRADCLFYLSYKGTPVKASRLFAGYEHELQSKRIAAHFQVSTAKFRTVTTNWKTIKQLKSVDAVKSFSIKTFSERDLSIFEDYETAYHQLIMDIVEVQYIATKRVMDETNIHRIFVDGGFSKNPIYMSLLSEKFEHQEVFAASMAQATAIGTALSIHRHWNSNPIPNDLIELKFYAKNNFKTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJZ1</accession>
    <name>D7VJZ1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpmA</name>
        <name evidence="7" type="ORF">HMPREF0766_11310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998765.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11310"/>
    <dbReference type="EnsemblBacteria" id="EFK58593">
        <property type="protein sequence ID" value="EFK58593"/>
        <property type="gene ID" value="HMPREF0766_11310"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095424_4_0_10"/>
    <dbReference type="OrthoDB" id="1904463at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="88" mass="9406" checksum="6D3D3ECF6F1A98A9" modified="2010-10-05" version="1">MAHKKGAGSSKNGRESHSKRLGIKIFGGQAAIAGNIIVRQRGTQHNPDLNVGIGKDHTLFALVDGKVVFRKKANNKSYVSVIPAEDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK58</accession>
    <name>D7VK58_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998949.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11377"/>
    <dbReference type="EnsemblBacteria" id="EFK58660">
        <property type="protein sequence ID" value="EFK58660"/>
        <property type="gene ID" value="HMPREF0766_11377"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_35_10"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="221"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="423" mass="49668" checksum="56593D106E96ADBE" modified="2010-10-05" version="1">MRLLNRTMLYLSGALLLILSVWAVIFYLDMMDEVYDSLDDGLENHKMLIIHRAYEDEMVYQKRDFGESNYRLIPVPEDIAISGLETYSDTSMYMVNEEDFEVVRMLTTYFQDNDGKYYKLQVISSMVEEDDLISSLLYSLLTLFVVVMTSIFIINKLILSKIWKPFYQLGHQLKKFELGKRNTFVAPKTSVLEFKELNNTITQLLDDNTAVYERQKDFVENAAHELQTPLAISQSKVEMLLPHFEKDEEVLNQLAEVLHQLDRMKRLNKSLLLLTKIDNRQFLNQEPTDFNMLWKKQIEAFRELLEHKSLQIDLLEEEVLIRDFNPDLAQMLISNLLRNAHIHNYEGGRIVVRIYKNRFTIANTGKEMALNTQHIFDRFYKDVENQQSTGLGLAIVRSIVDSTNGHIDYTYTDHMHSFTVHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK70</accession>
    <name>D7VK70_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6268 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998985.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11389"/>
    <dbReference type="EnsemblBacteria" id="EFK58672">
        <property type="protein sequence ID" value="EFK58672"/>
        <property type="gene ID" value="HMPREF0766_11389"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZBBF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072583_0_0_10"/>
    <dbReference type="OrthoDB" id="816614at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046235">
        <property type="entry name" value="DUF6268"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19783">
        <property type="entry name" value="DUF6268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6268" evidence="1">
        <location>
            <begin position="106"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="331" mass="37204" checksum="0994709CD5E034F6" modified="2010-10-05" version="1">MKTLIVIKNGDIGSRLSVISNGKYKALTTCTRLYLVALFSILFIHNSYSQIIQDIGGIAVTSHNKTTFKDMPLGSLDSENKFQLNTYDAWLSVPPVNIGKTSIFTNMNYRLMDFNYDDNTIDDPNRIGRIQEIKSTLIIQHPISRKWSVMAIAMPTLAGEKSVSFDDLILDGILGVSKKFGSESNLEIGFGVHALYSFGETLITPGITVDYRSTNNKWLAQFYWPRLNVLYNVSSNTQVGLAGSIDWTRFNLKNYRGYNDREIDYAQFSTIHGGLQIHQRLIGGLWLQAQGGMGLLNSYELYDTNQKTVNKSSISNMAYGKAALTYRIGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKQ0</accession>
    <name>D7VKQ0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999436.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK58852">
        <property type="protein sequence ID" value="EFK58852"/>
        <property type="gene ID" value="HMPREF0766_11569"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033645">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175396_0_0_10"/>
    <dbReference type="OrthoDB" id="1749079at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="107" mass="12680" checksum="67B2F4135A775DA7" modified="2010-10-05" version="1">MCQSILLSEKGTTHVSLCNKCQTFYIWQSSFVLTFTRRQFETFVETTLSQGNDHCFVNFPDGEFRLLLNTPCPEIVFNFRKEEWDDFVEALTESFYMQEVYSMIEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL24</accession>
    <name>D7VL24_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SusD-like_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11693"/>
    <dbReference type="EnsemblBacteria" id="EFK58297">
        <property type="protein sequence ID" value="EFK58297"/>
        <property type="gene ID" value="HMPREF0766_11693"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_863069_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107637" description="SusD-like_3 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="SusD-like_3" evidence="2">
        <location>
            <begin position="95"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="322" mass="35618" checksum="46A046FAD6491104" modified="2010-10-05" version="1">MKKNTLFRILVLTTLLVTSFSCTKLDEKAVSILTPEQYFKTEADAEASVMGIYSLLANADSYGRRLVMVLQLLGDDCDIGDIGTQSSRIQLNSFRHDSSNQDVLAVWRTAYLGIGAANAAIDGIPAVTMNDTKKAALIAEARLLRALYYYHLVQLFGDIPYIGEYVSDPSKVTNISKTSAEKVYENIIADCEFAIKNLPDTYSGAVKARPTKGSAHTLLASVYMILKRWPEAAEQAEIVIKNASTYQYGLVQDYQNLWKADLGYQSEHIWVVDFAGKMTGENNANVDYTAPMTGVRDADMLGWSDLQQECITVSLMKTIGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLA4</accession>
    <name>D7VLA4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SNF2 family N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999933.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11773"/>
    <dbReference type="EnsemblBacteria" id="EFK58377">
        <property type="protein sequence ID" value="EFK58377"/>
        <property type="gene ID" value="HMPREF0766_11773"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_21_3_10"/>
    <dbReference type="OrthoDB" id="325071at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="510"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="795"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="960" mass="111588" checksum="6F94B28D2E49F7CC" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLF2</accession>
    <name>D7VLF2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_11822</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000069.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11822"/>
    <dbReference type="EnsemblBacteria" id="EFK58425">
        <property type="protein sequence ID" value="EFK58425"/>
        <property type="gene ID" value="HMPREF0766_11822"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_2_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107381" evidence="5">
        <location>
            <begin position="22"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="117"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="406"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1015" mass="110158" checksum="54D2DE713D5748B2" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLJ1</accession>
    <name>D7VLJ1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, group 2 family protein</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000167.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11861"/>
    <dbReference type="EnsemblBacteria" id="EFK58464">
        <property type="protein sequence ID" value="EFK58464"/>
        <property type="gene ID" value="HMPREF0766_11861"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_21_1_10"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="250" mass="28915" checksum="7E1E1F4CBEDC81DD" modified="2010-10-05" version="1">MAHPKISIITIVYNNVRDIRYTLDSVATQSYNNIEYIVIDGLSTDGTLAVIDQYKSHIHVLKSEKDKGIYDAMNKGLALATGDYVLFLNSGDELFSPSTLSDIFENCEMADIYYGETKLVDEDRRILGDRRHRIPEHFDWKSFRYGMNVCHQAIYIKRELTEPYDTSYQLSADIDWVIRAAKKARTTVNTHHYVAKYLVGGMSQKRHKQSLKERYAIFKKHYGTIPNIFHHAVIAARLLLYRIKNGKTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLN0</accession>
    <name>D7VLN0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000256.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11900"/>
    <dbReference type="EnsemblBacteria" id="EFK58503">
        <property type="protein sequence ID" value="EFK58503"/>
        <property type="gene ID" value="HMPREF0766_11900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8TX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036786_1_0_10"/>
    <dbReference type="OrthoDB" id="526432at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="405" mass="46594" checksum="1AADB2B0DA48FF25" modified="2010-10-05" version="1">MVMKSTGKFGIIVLLIALVLIAIIDATSRKPIDWRKSFDQRDKIPYGLYVLHQELGNILGNDRKIESTKKSVYETLEEDSLHAKNTAFVFIGDYIDIMGATATEKLLQFAKEGGEVFISTNYYSANLLDTLNLSSAYLDVNKFSGFSLLGDINYSLVNSRKTIKYDKIEQTSIFDLIDSTNISIAGNAYAGKHAVPNFVEVSWGKGKLYLHHTPEMFTNYYMLQHQKYDYAASALKLIKAKHIIWCDNYYREGQPSTPLRMILSYEGLREAWYLLLFGLLLFLLFRSKREQRAVEVVTPEPNLSKEFAKTIGTLYYENGEPGNMIDKKIDYFLFDIRNHFQLDTLQLSDEKFLNNLSLKAAIPLAETEELMNLITRYRNRKDLSTHDLKFINSKIEEFKTKSNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLU1</accession>
    <name>D7VLU1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001587.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12195"/>
    <dbReference type="EnsemblBacteria" id="EFK58203">
        <property type="protein sequence ID" value="EFK58203"/>
        <property type="gene ID" value="HMPREF0766_12195"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_828687_0_0_10"/>
    <dbReference type="OrthoDB" id="1851189at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107398" evidence="1">
        <location>
            <begin position="22"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="289" mass="32855" checksum="581057FCAA7C7D03" modified="2010-10-05" version="1">MYCIRFIILLLCLGITALSKAQVYNDIARYAIYGTPQYGVKIQTNIPFTVSADMPTINLIGYSYGAKAPMSLQITFYIWHDNNVLYFYQPVISSSGAYTPRILLANEGGKVVIFIDDKVYFQRFYVNAFSGYNQPSYYQGWSIIDAPLTGTDIAEFSYTNRFKGDIYLSGNGIWNSQGNVGIGTISPQEKLSVNGKIRAHEIKVETANWPDYVFAKDYKLMELDELAAYIREKGHLPKIPKAEEIEKNGVALGEINRTLVEKVEELTLYLIKYAEEVKELKKEIHELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLV0</accession>
    <name>D7VLV0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12204"/>
    <dbReference type="EnsemblBacteria" id="EFK58212">
        <property type="protein sequence ID" value="EFK58212"/>
        <property type="gene ID" value="HMPREF0766_12204"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3296714_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="40" mass="4826" checksum="FEEF23A8ACDC8098" modified="2010-10-05" version="1">MSPDYMAYRGDGQGKHLINWSLNKREEHLWKLLVHKMLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLY0</accession>
    <name>D7VLY0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">recQ</name>
        <name evidence="12" type="ORF">HMPREF0766_11977</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK57985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001095.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11977"/>
    <dbReference type="EnsemblBacteria" id="EFK57985">
        <property type="protein sequence ID" value="EFK57985"/>
        <property type="gene ID" value="HMPREF0766_11977"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001103_14_3_10"/>
    <dbReference type="OrthoDB" id="54580at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006293">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01389">
        <property type="entry name" value="recQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="28"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="221"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="9">
        <location>
            <begin position="531"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK57985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="729" mass="82373" checksum="09BC7750474523E0" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLZ5</accession>
    <name>D7VLZ5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11992"/>
    <dbReference type="EnsemblBacteria" id="EFK58000">
        <property type="protein sequence ID" value="EFK58000"/>
        <property type="gene ID" value="HMPREF0766_11992"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2720310_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107676" evidence="1">
        <location>
            <begin position="19"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="72" mass="8387" checksum="54650E6EC4716BFF" modified="2010-10-05" version="1">MKYIIISALFLISKFSLAQHMNEISALEFKFSISITQNNTIFNPPEKIIDIFSYKDLMLCKLPIMAFIKMTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMG0</accession>
    <name>D7VMG0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipase, patatin family</fullName>
            <ecNumber evidence="4">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001505.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12157"/>
    <dbReference type="EnsemblBacteria" id="EFK58165">
        <property type="protein sequence ID" value="EFK58165"/>
        <property type="gene ID" value="HMPREF0766_12157"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047251_2_1_10"/>
    <dbReference type="OrthoDB" id="373926at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="36"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="67"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="183"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="289" mass="32255" checksum="D79896179BD4DEFE" modified="2010-10-05" version="1">MFKHFMLFRLFNDNFFLLKYCIFSVMNAARKKHVSLVLGSGGARGIAEIGVIHALEAKGYTIDEIVGCSIGSLVGGVYAQQKLSDFQDWLKTLSKREIFRLMDFTYSGSGVMKGIRIFEALKQIVPDINIEDLPIRYTAVATDLKKEQDVIFRTGSMYDAIRASIAIPAVFTAVSIDEQFLVDGGVLNPLPINHVQHKHNLVVAVNLDGQPDPELAQTKNKPEKVNSIGVLTHAYYAMRRQLAAQSIALYKPDYVVTIPHNISGLWDYDRSEYLIEKGALLTENALSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMG3</accession>
    <name>D7VMG3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, NAD-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001510.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12160"/>
    <dbReference type="EnsemblBacteria" id="EFK58168">
        <property type="protein sequence ID" value="EFK58168"/>
        <property type="gene ID" value="HMPREF0766_12160"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_24_0_10"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043906">
        <property type="entry name" value="Gfo/Idh/MocA_OxRdtase_bact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19051">
        <property type="entry name" value="GFO_IDH_MocA_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107054" evidence="1">
        <location>
            <begin position="26"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="45"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C2" evidence="3">
        <location>
            <begin position="217"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="476" mass="53115" checksum="ECAAF8AE2F420095" modified="2010-10-05" version="1">MKNTTSFSRRTFLRNSLLLSGATIALPSFLAASAPVKLARPNERINLACIGIGNRGADIIQDLYKTGLVNIVALCDVDMGASHTLPILQQFPDVPRFQDFRQLFDKMSNQIDAVSIGVPDFSHFPITMMAIDLGKHVYVEKPMARTFQEVELMMKKAAKFNKVVTQMGNQGHSEANYFQFKAWKEAGIIKDVTAITAHMNAPRRWHTWDTNIKSFPPKEPTPATLDWELWQMATQGHDFNKDFVNGQWRCWFDFGMGALGDWGAHILDTAHEFLDLGLPYEINPVNLDGHNDFFFPMSTTLAFRFPKRGDMPALDITWYDGINNLPPIPEGYGVSGLDPNIPPPTTGKIEPAKLNPGKIIYSKNLTFKGGSHGSTLSIIPEEQALAMAGKLPEVPQSPSNHFLNFIRSCKGEEKTRSSFDIAGPLSQVFCLGVLAQKLGTKLEFDRKSKKITNNKVANSLLAGPPPRKGWEQYYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN67</accession>
    <name>D7VN67_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Prophage_tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992980.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12437"/>
    <dbReference type="EnsemblBacteria" id="EFK57364">
        <property type="protein sequence ID" value="EFK57364"/>
        <property type="gene ID" value="HMPREF0766_12437"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4926">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_598399_0_0_10"/>
    <dbReference type="OrthoDB" id="285559at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010572">
        <property type="entry name" value="Prophage_Tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06605">
        <property type="entry name" value="Prophage_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prophage_tail" evidence="1">
        <location>
            <begin position="112"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="457" mass="52711" checksum="624C49CD96EAE72D" modified="2010-10-05" version="1">MITIKRGISIIAVVEPMDTVTQEKEVSGGNFINLSFELPYYREFKRMDYAEILGETYYLTQIPTVSKEGKRDYQYTLSMEGEQCKLGRVEFLQSNLIGQYFKNPFFINDKAETFMTLLLRNIERVFPGEGWKLGYVVDSEIKNISFENQNCLEALSTLAEAFDTEWLIEGRTIHLYRKQSATGLVMKQGEGEALYSLEKKPQDNSNIVTRLYVYGSDKNLPNPYRRGLTRLTVGDLPYIERQIEEYGIWEDSMTFDDIFPMNLGTITSVDSGNILRFTDANFPFDINSQLIPDVKAKLSFQIGQLAGYEFEISSYNHTTKTFTINKNTQDKAWEVPNADIKPEVGDTFFVFDIRMSNAWVTAAEQTLRQKAIEYMDQRNDPSENDTYSVVCNPLYFKRTGKTLRIADSVTIEEPDMGILTQKRIVKLSRNVRQPFIYTCELANRPKKNVMVKLLQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNA9</accession>
    <name>D7VNA9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993035.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12479"/>
    <dbReference type="EnsemblBacteria" id="EFK57406">
        <property type="protein sequence ID" value="EFK57406"/>
        <property type="gene ID" value="HMPREF0766_12479"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050370_0_0_10"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026497">
        <property type="entry name" value="GRASP-with-SPASM"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04193">
        <property type="entry name" value="SPASM_w_grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="384" mass="44582" checksum="4C0109A3EB4ADA4B" modified="2010-10-05" version="1">MFNVSNRLFITQKTIQTIDETAMRFFNLYSDIYITKGYNRILISDLGRSISKLYPLELHELIEELKSASIESVLENYDSGSKAIAEEYIGYLLEKEYGFVTEGDWDKNFLPLSYEYHDHQQISNLYIEVEKLEIPATLIQSIANLRITHLVVFCRSAASAQELIDFEKAFDNTALEGLELYSAYSTELNADFFQNIHDHTQRIYHLVFYQCEEIPVLTNTSYRFTLDFKRDSLSLHSCGKVNVDYFNTNMPKVLEAINHNSCLHKKLGIDRNGNIKNCPVMPQSFGNIHDMTLEEVLQQGAVQQYWNMTKDEITVCKDCEFRNVCTDCRAFTERSDYNESGLDVSKPLKCGYDPYSNEWSEWSLNPLKELAMTYYGFEKLAQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNB0</accession>
    <name>D7VNB0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RimK-like ATP-grasp domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993036.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12480"/>
    <dbReference type="EnsemblBacteria" id="EFK57407">
        <property type="protein sequence ID" value="EFK57407"/>
        <property type="gene ID" value="HMPREF0766_12480"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055286_0_0_10"/>
    <dbReference type="OrthoDB" id="937913at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026455">
        <property type="entry name" value="GRASP_w_spasm"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04192">
        <property type="entry name" value="GRASP_w_spasm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="300" mass="35115" checksum="3D258FDFE00DEF30" modified="2010-10-05" version="1">MILIISKNNEITTTAVIKWLRALHKPFIRIHEDEVFEIHTSKKRIVLKSQRNQFFLDEISAVWYRRGGIAFNELRYHNQAIDRYMFEVQHWLTDYVIQTLEEKKHLNKQSNSHVNKLLVLEKAKEAGLDVPEYFLAEDMEDVIAHQTIVKPISGTPIIDDIQENQSGIMYTSLIEQKKESGFFISFFQEKIEKDFEVRSFFLNGKIYSTAIISQNDEKTRIDHRRYNTQTPNRNVRYKLPAEVEQKINVLMQSLDLNSGSLDFIKSGDTFYFLEINAIGQFLGMSNTCNYGLEKEIAAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNL7</accession>
    <name>D7VNL7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993172.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12587"/>
    <dbReference type="EnsemblBacteria" id="EFK57514">
        <property type="protein sequence ID" value="EFK57514"/>
        <property type="gene ID" value="HMPREF0766_12587"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZBN8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1802666_0_0_10"/>
    <dbReference type="OrthoDB" id="1439160at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="142" mass="15958" checksum="E25AC2AC77D49A38" modified="2010-10-05" version="1">MEALSDLKTFAKILTDKGYNGYFHTQGAYARKLKDSISEYLKSCQKGADNLPKQDLFLTGYLQWSGDDKPRVECSMWVKYLNGKFSLSRMEIAKKDGFGQLLKKSELANLSVISAPKLTEAVALVNDEPKQQAGKSPKRFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNS4</accession>
    <name>D7VNS4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993263.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12644"/>
    <dbReference type="EnsemblBacteria" id="EFK57571">
        <property type="protein sequence ID" value="EFK57571"/>
        <property type="gene ID" value="HMPREF0766_12644"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152583_0_0_10"/>
    <dbReference type="OrthoDB" id="1997313at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="101" mass="11366" checksum="520633E5FFFCC91F" modified="2010-10-05" version="1">MEQYSDMVQALKDLRQRGYSIDFSLLPDCLYCASKSLKLKPEDFTVTETHRFESLDSSPDNNAVIYAISSNDGKSKGVLVDAYGTYAEEMTHEMVKKLNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNV0</accession>
    <name>D7VNV0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993303.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12670"/>
    <dbReference type="EnsemblBacteria" id="EFK57597">
        <property type="protein sequence ID" value="EFK57597"/>
        <property type="gene ID" value="HMPREF0766_12670"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4994">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141608_2_0_10"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="11"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="125" mass="14096" checksum="5572468E56AE41EB" modified="2010-10-05" version="1">MSSIILNEQKILDIENQLREAMQKSDVGILDQLLHDDLLFVLSDGEVITKEMDLETHRSGNLVLEEITSSIDSVKQIGENVVVTLSSKIKGKMLEQNFEGNFRYLRVWKMFDGQLKVIAGSCVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNY4</accession>
    <name>D7VNY4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57631">
        <property type="protein sequence ID" value="EFK57631"/>
        <property type="gene ID" value="HMPREF0766_12704"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033QNQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_653498_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="395" mass="45667" checksum="F723C022A123828A" modified="2010-10-05" version="1">MLSIKTYAQEKQTYWKPENVTKVNNKSMWGITLAYMDMIAEMRIHLSESKDVLYFSYPYEKIIKISDLKSLTDCRLKNTGELLDSVYEVAIEKDTLKIKFNYIGTADKDNRFSLNMIPVKQDEYNSEVERLKKHKEDILSKIKTIDLSALNLEWTLPDYFKEKGLSDLNPVQLAEELAEVNDGFRITSDRIVLTKDKNKIEYNNYGVENINRIGLPAARIHTVNFDNIEFVSSTSAHKADAIIIAQNTMGKSEIKNLFNSISEKLAGDSLAQFGLPVLYDDKTSLGIHSFFAVSWTGKDKVVRLAIDNVPDDLFDKEIDNDIALPETYNAADINKVLRHYLDLIPTSRVRVFIVSKEFDEIQHLKENRMDGLTHGNIRDHVFKWKYYHELWDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP13</accession>
    <name>D7VP13_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter, SSS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_12733</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993418.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12733"/>
    <dbReference type="EnsemblBacteria" id="EFK57660">
        <property type="protein sequence ID" value="EFK57660"/>
        <property type="gene ID" value="HMPREF0766_12733"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019510_1_0_10"/>
    <dbReference type="OrthoDB" id="231452at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="583"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK57660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="610" mass="68531" checksum="4A539751DCC40CA9" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP24</accession>
    <name>D7VP24_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_12744</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993433.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12744"/>
    <dbReference type="EnsemblBacteria" id="EFK57671">
        <property type="protein sequence ID" value="EFK57671"/>
        <property type="gene ID" value="HMPREF0766_12744"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_3_5_10"/>
    <dbReference type="OrthoDB" id="406005at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="22"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="350"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="488" mass="54168" checksum="CAB84BC94D078E1A" modified="2010-10-05" version="1">MKKYIKILLAASVLSTAYSCKDFLEVEPSNAVDYDKAIRTANDAQIVVNGILRQMTSSNYYGRNFIIYGDAKGGDFTLFSQGRGLDPFYTFNHSAQANSYSSFWTSIYNIIYQANNLLENIEKLQSQGTLENFALAKSDALTIRALAYFDLVRLYGKSYTDDKNAWGVPNITKTLLYDSQPARSTVAENYTQIMKDLKDAEAGLPKTKRDGYVNYYANKAIQARVYLTMGDYDNALKASEEVINSGVYSLYTNAQWVSSWSNQFGSESILEFVIEPNQGDLARTSLAFYLMRRNHQTGALGNFLASTPFLTALNADPNDVRKGVMARDESSATRLGSCYKYSGSVAFSGDKGSSNFTAVNIKVIRLSEMYLTAAEAALKSSVPNPTKAAEYLQAIRKRAPALTPATAANVTEDLILAEKSKEFFGEGIRYFDMLRLNKTINFDDAFAGISVPTRTSSINRSFYRTILPISQDEINANPDIQGQQNPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP72</accession>
    <name>D7VP72_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1080 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993506.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12792"/>
    <dbReference type="EnsemblBacteria" id="EFK57719">
        <property type="protein sequence ID" value="EFK57719"/>
        <property type="gene ID" value="HMPREF0766_12792"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8R6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1184141_0_0_10"/>
    <dbReference type="OrthoDB" id="1452706at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107483" description="DUF1080 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1080" evidence="2">
        <location>
            <begin position="59"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="235" mass="26383" checksum="9755E553390A00C6" modified="2010-10-05" version="1">MKRYLIPFFFLILYSTALRAQDKKTLSFGSEIPLSTLNGNTNIKAKPIQWIDVNTSPETWFKQKDLLICKGLPIGVMRSEKMYENFILHVEWKHMEAGGNSGVFIWCDAVPQEGTRLPAGVEVQMLELDWVNQHIRDGVKPPIAYVHGELFGAGGVTTIPDNPRGERSKSIENRAKGKGEWNTYEVVCVDGTVKLSVNGKFVNGVRQSSSSKGYLCLESEGAEIHFRNLRIIELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPD8</accession>
    <name>D7VPD8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 14">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="7">IMP dehydrogenase</shortName>
            <shortName evidence="7">IMPD</shortName>
            <shortName evidence="7">IMPDH</shortName>
            <ecNumber evidence="7 14">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 16" type="primary">guaB</name>
        <name evidence="16" type="ORF">HMPREF0766_12858</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 14">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 13">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="7 14"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993630.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12858"/>
    <dbReference type="EnsemblBacteria" id="EFK57785">
        <property type="protein sequence ID" value="EFK57785"/>
        <property type="gene ID" value="HMPREF0766_12858"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022552_0_1_10"/>
    <dbReference type="OrthoDB" id="532857at2"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 7 14" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="97"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="157"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="341"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="364"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="388"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="7 8">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="251"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="301"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFK57785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="491" mass="52232" checksum="76B5B42C4B74CD3B" modified="2010-10-05" version="1">MQLDPQKFVAEGLTYDDVLLIPAYSEILPRDVDTSTYLTKKIKLNIPLVSAAMDTVTGSDLAIAIAQAGGIGMLHKNMTITEQAAEVRKVKRSESGMIQDPVTLLETATVGDAFKIMSEHKIGGIPIIDGSGKLVGIVTNRDLRFQKDMKRPISELMTRDNLVVAPEGTDLVQAELILQNYKIEKLPVVNEEGLLKGLITFKDIQKYKHYPNAAKDSHGRLMVGAAVGVTPDTLDRVDALVKAGVDVVTIDTAHGHSKGVIDKLKLVKSTYPELQVIVGNIATGAAAADLAAAGADAVKVGIGPGSICTTRIIAGVGVPQLYAVYEVAKALKGTGVPLIADGGIKQTGDIAKAIAAGASTIMAGSLFAGVEEAPGETIIYEGRKFKSYRGMGSIEAMEKGSKDRYFQDVEDDIKKLVPEGIVGRVPYKGTLSEVVYQYIGGLRASMGYCGAATISRLQEAQFVRITGAGLRESHPHNISITKEAPNYNSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPE3</accession>
    <name>D7VPE3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993635.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12863"/>
    <dbReference type="EnsemblBacteria" id="EFK57790">
        <property type="protein sequence ID" value="EFK57790"/>
        <property type="gene ID" value="HMPREF0766_12863"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032S67">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158632_0_0_10"/>
    <dbReference type="OrthoDB" id="1819243at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="125" mass="14146" checksum="875573F08CF10850" modified="2010-10-05" version="1">MKSKNKKAWLLIIPIILIVGFIFKDSLTQKSIADLKGDFKEVAFVRNEQNKGGIIRIYAISVGDIANADYEGAADLFPTNDYGSSTTIYFFDKNFPFPTELKLESPHFDLDKYKSIMIIKRTGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPG1</accession>
    <name>D7VPG1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Magnesium transporter MgtE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mgtE</name>
        <name evidence="9" type="ORF">HMPREF0766_12881</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a magnesium transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12881"/>
    <dbReference type="EnsemblBacteria" id="EFK57808">
        <property type="protein sequence ID" value="EFK57808"/>
        <property type="gene ID" value="HMPREF0766_12881"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037408_2_2_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00400">
        <property type="entry name" value="mgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="190"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK57808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="450" mass="51135" checksum="0DAA9A4377D5B376" modified="2010-10-05" version="1">MPRFVHHNNVVPMDQNNLLHPADIAEQLAELTGRELYEEFSVYPLDIRLEIFSFFDSASQYELIKQLSEKELSEFLNNLKPDLRNELFYQLPDEMIKYLINLLNEREKQMALELIGYKEDSIARLMTPMYVQVRLHYTVADVFRHIKLFGRKAETLNFVYVVDGQNVLIDDLKIGQLLLADENTKISELVDYNFAAIRASTPMEEAFEIFQKYDRSALPIVTDSGVLVGIVTFDDMLDRIEDRDTEDIHRFGGMDELDLAYTKTPLLELVRKRAGWLIILFLSEMLTASAMSYYDGEIAKAVVLALFVPLIISSGGNSGSQAASLIIRAMALGELKLKDWWYVMKREISSGIILGAILGSIGFIRILLWQQLGIYDYGEYWFYIGLSVSISLLFIVLWGTLSGSFIPFILRRLGMDPATASAPFVATLVDVSGLIIYFSIAAFFLSGKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPH6</accession>
    <name>D7VPH6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase, S9A/B/C family, catalytic domain protein</fullName>
            <ecNumber evidence="3">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993717.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12896"/>
    <dbReference type="ESTHER" id="9sphi-d7vph6">
        <property type="family name" value="DPP4N_Peptidase_S9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57823">
        <property type="protein sequence ID" value="EFK57823"/>
        <property type="gene ID" value="HMPREF0766_12896"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006105_2_0_10"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPPIV_N" evidence="2">
        <location>
            <begin position="97"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="503"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="707" mass="81205" checksum="D1D1755539771B06" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPM9</accession>
    <name>D7VPM9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase, M28 family</fullName>
            <ecNumber evidence="8">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_12949</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993810.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12949"/>
    <dbReference type="EnsemblBacteria" id="EFK57876">
        <property type="protein sequence ID" value="EFK57876"/>
        <property type="gene ID" value="HMPREF0766_12949"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033697_1_1_10"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039866">
        <property type="entry name" value="CPQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12053">
        <property type="entry name" value="PTHR12053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M28" evidence="7">
        <location>
            <begin position="285"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK57876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="521" mass="57639" checksum="7A817862381A2E65" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPN9</accession>
    <name>D7VPN9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993821.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12959"/>
    <dbReference type="EnsemblBacteria" id="EFK57886">
        <property type="protein sequence ID" value="EFK57886"/>
        <property type="gene ID" value="HMPREF0766_12959"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503318C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111146_0_0_10"/>
    <dbReference type="OrthoDB" id="1806345at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="212" mass="25468" checksum="F05DA58863CA6ED9" modified="2010-10-05" version="1">MNFDELKKQWNDQSSEQVQINPDLDQYKEVDNVLTKLRKNVKYEFITWIVAMLFLLVVPLIELYKIEGYARFAYYLIFFQMLLSSMIYYRRFFYFYKSASQSEVLSSRENLLKMYYDLKFAIDSYKTTSYVMIPQALIMYMIMLSNGKFESWFNKLYHIGSTLAQDSNFIVWFVLSTIVSIALVIFIIEIMSYSYYGKHLKEIKKILNQLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPP5</accession>
    <name>D7VPP5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12965"/>
    <dbReference type="EnsemblBacteria" id="EFK57892">
        <property type="protein sequence ID" value="EFK57892"/>
        <property type="gene ID" value="HMPREF0766_12965"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2234872_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="105" mass="11704" checksum="01DF01B6C31B2F6D" modified="2010-10-05" version="1">MLFFPAILLQVLAEIFANDRFVAFDGSGRSTGSLLVLSAVFSMLLCVACLFPLINVWDAPKLLTLIRINRRGSVFNILKIFIKYINLFGGIPVVADQLKGMKRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPT1</accession>
    <name>D7VPT1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_13001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993883.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13001"/>
    <dbReference type="EnsemblBacteria" id="EFK57928">
        <property type="protein sequence ID" value="EFK57928"/>
        <property type="gene ID" value="HMPREF0766_13001"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_3_0_10"/>
    <dbReference type="OrthoDB" id="758760at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="22"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="345"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="482" mass="54857" checksum="4A24C295A62564BD" modified="2010-10-05" version="1">MRAYIILLLTVISAGFSTSCSKFLDEPYDNRLDLTQGLDILEDVLVNAYPERQDMFTEILTDNYHHYANTMQANMGARYIPLYLWKDEYEETNIASPGAAYAHYYKKIYDANSVIEELAKASGDETQKKAIKGEALMIRSYAYFSLVNLFGMHYNTATSATDLGVPLVLEVPKANRPLFDRATVKQVYDQIEKDMNEGLALLKEGREFMPNTPYRFSMASIYAFFSRVSLYKGNWDDVIKYSDLAVAEKGVIVRKMSDDVNRKRTTSEQYWAQEIMNPSIHPNLLLTAQSSQFLCRPIGYRLCGFYLAHEIFYSTPNSDLRFQSFSSGGTVIDSVALVVKYANQPNNPNAAASRYDCFTMEEVLLNRAEAYLRIASPNITKAMQDIEAIRKERITPYTALPTPSTTDNALATVLKERRMELIGQGFRWYDIKRLGLRIEHRLVRTSATPDVVLEPNDKRTAIQIPINARVGNPSLENQLNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPU3</accession>
    <name>D7VPU3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993901.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13013"/>
    <dbReference type="EnsemblBacteria" id="EFK57940">
        <property type="protein sequence ID" value="EFK57940"/>
        <property type="gene ID" value="HMPREF0766_13013"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060500_4_2_10"/>
    <dbReference type="OrthoDB" id="1387978at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107126" evidence="1">
        <location>
            <begin position="20"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="41"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="269" mass="29530" checksum="F5B81A17AE5C6AF1" modified="2010-10-05" version="1">MNKLKILMLTCFVSIASLACSSDKKEIPEPKTEKSKLTVITYNIHHGAPENSEVVNLENIANTIKQKNPDLVALQEVDVNVPRSGKVDQAKKLAELLNMNYYFSKSLDYNGGEYGVAILSKFPISNTRRLELPMPVAGEKRTVAMATIDLGNGKTLEFASTHLDLNVPNRTAQATFLNELSVQLNKPIMIGGDYNAESNSVELTELRKQYTLSCVNGCPNSFPVRNPTKAIDFVASNKLAVQQYSLLSAVALTGSYASDHLPVVAIYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPX4</accession>
    <name>D7VPX4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14334"/>
    <dbReference type="EnsemblBacteria" id="EFK57131">
        <property type="protein sequence ID" value="EFK57131"/>
        <property type="gene ID" value="HMPREF0766_14334"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3122807_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="50" mass="6039" checksum="264F8C89ED151B3E" modified="2010-10-05" version="1">MKTIEKQFDAVKYMREQREQLSDKLSKMSKAEIIKYFRKKKSESKIKPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ76</accession>
    <name>D7VQ76_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994080.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13130"/>
    <dbReference type="EnsemblBacteria" id="EFK55927">
        <property type="protein sequence ID" value="EFK55927"/>
        <property type="gene ID" value="HMPREF0766_13130"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_4_1_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014327">
        <property type="entry name" value="RNA_pol_sigma70_bacteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02985">
        <property type="entry name" value="Sig70_bacteroi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="124"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK55927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="192" mass="22379" checksum="6D28DFDD58C150DB" modified="2010-10-05" version="1">MFTYTCLSDQELVALLKQGNRTAFAQIYDRYKQLLYVHALKKLRSEAEAEDIIHDLFATLWNNRETFELKSNLMGYLYTAVRNRIFKLLAHKDIESAYIASFHEVAEQAGNMADHRVRENQMMEMIEAEIAALPAKMREIFELSRKQHLSHKEIAGQLHISEQTVSKQVSNALKILRNKLGLIAYLMLLMRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ79</accession>
    <name>D7VQ79_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13133"/>
    <dbReference type="EnsemblBacteria" id="EFK55930">
        <property type="protein sequence ID" value="EFK55930"/>
        <property type="gene ID" value="HMPREF0766_13133"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50349K2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2481707_0_0_10"/>
    <dbReference type="OrthoDB" id="1866559at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="98" mass="11176" checksum="6EBA942D877CBB5B" modified="2010-10-05" version="1">MVKRFLILNGMSTPIQLYQDFLEIFQKYSVQELIEVNNQDLQEHGRPGSRGAFRTALLHAFSLRGLDLSRIVSKEDGFTSITISALRLENNVLIPINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQB2</accession>
    <name>D7VQB2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Deoxynucleoside kinase</fullName>
            <ecNumber evidence="5">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_13166</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994156.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13166"/>
    <dbReference type="EnsemblBacteria" id="EFK55963">
        <property type="protein sequence ID" value="EFK55963"/>
        <property type="gene ID" value="HMPREF0766_13166"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030466_2_1_10"/>
    <dbReference type="OrthoDB" id="1275854at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019136">
        <property type="term" value="F:deoxynucleoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01673">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002624">
        <property type="entry name" value="DCK/DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000705">
        <property type="entry name" value="DNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="dNK" evidence="4">
        <location>
            <begin position="3"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="7"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="180"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK55963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="204" mass="24092" checksum="113DD5EC2B528732" modified="2010-10-05" version="1">MHIAIVGNIGAGKTTLTQLLANHFKYEPQFEAVDNNPYLEDFYADMKRWAFNLQIFFLNSRFRHIVQLQEKGIDMIQDRTIYEDAYIFAENLFDMGLMSERDFENYSNIFQSIIHYIKPPDLLIYLKASVPTLVNNIQRRGRDYESAIRLDYLSKLNDKYDKWINNYKDGKVMILDKDNLDFTSNPEDLGFIIQKIEAELFGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQC6</accession>
    <name>D7VQC6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, ATP-binding protein</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_13180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994193.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13180"/>
    <dbReference type="EnsemblBacteria" id="EFK55977">
        <property type="protein sequence ID" value="EFK55977"/>
        <property type="gene ID" value="HMPREF0766_13180"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_10"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="323"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="565"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="355"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK55977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="638" mass="72904" checksum="4C86A80FD081AED6" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQF0</accession>
    <name>D7VQF0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994244.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13204"/>
    <dbReference type="EnsemblBacteria" id="EFK56001">
        <property type="protein sequence ID" value="EFK56001"/>
        <property type="gene ID" value="HMPREF0766_13204"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1170064_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="202" mass="22497" checksum="D3D028E4A6E01268" modified="2010-10-05" version="1">MKTILISSLIILFIGITSCQKQNDLIPNKDSNQFINIGEVVYNSSSNLYYNNKGKLIDLDSIKKTLKPNQFLEVSSLSIISDEGIDNSPNDINNIPNRKRTANTAKNAHTQGYIVNIDNHIWWGADNLDNGGDIGISTSAKAFIFRPGELYMRHAKFKFASGSNNDGAVWARNFLWALYQADPTDTVILSDFKGPAMTFPFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQJ5</accession>
    <name>D7VQJ5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DinB_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994341.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13249"/>
    <dbReference type="EnsemblBacteria" id="EFK56046">
        <property type="protein sequence ID" value="EFK56046"/>
        <property type="gene ID" value="HMPREF0766_13249"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1561020_0_0_10"/>
    <dbReference type="OrthoDB" id="1717097at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="30"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="172" mass="18921" checksum="84F44F29D5196BF7" modified="2010-10-05" version="1">MKKATEPEVWMRGPVAGVPGLLQPVAHALLQAKEDITDAVKGIDEQSLWQRPAGVASIGFHLQHITGVIDRMFTYAQDLPLSEQQLSYLAKEGLVDPTVTLESLLLQLEVQLQSAISQLCSTDTDQLTATRYLGRKRIPTTLTGLLFHAAEHTQRHTGQLLVTARVLLCPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQP0</accession>
    <name>D7VQP0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13294"/>
    <dbReference type="EnsemblBacteria" id="EFK56091">
        <property type="protein sequence ID" value="EFK56091"/>
        <property type="gene ID" value="HMPREF0766_13294"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032VD0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1748481_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025348">
        <property type="entry name" value="DUF4252"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14060">
        <property type="entry name" value="DUF4252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="149" mass="17026" checksum="8A1F2C9A94101E13" modified="2010-10-05" version="1">MDFVQHNSISKGAEIVSVKVPGLLLNPFLKSSIKELEEEDPMIAMLLKKLKSLKVMTISNDKKGLLMKDFNKYLAKNKFEEMASIHSEGSVVSINGKMKGDRIKRLMLGIADEDELVFLDIKSDLDLNELAQMISYYEQKQEKQKQEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQU0</accession>
    <name>D7VQU0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994473.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13344"/>
    <dbReference type="EnsemblBacteria" id="EFK56141">
        <property type="protein sequence ID" value="EFK56141"/>
        <property type="gene ID" value="HMPREF0766_13344"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032ZRJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132570_0_0_10"/>
    <dbReference type="OrthoDB" id="1915424at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="139" mass="16449" checksum="DC1C84960D6C155F" modified="2010-10-05" version="1">MPEKQGYVSLQKEITLTKQFYIYVLLLSFVMQMFVRVAIVVDYSTNKSLYLQYCENKSRPELHCNGQCVLMKKLKKQEEKESKQVSQKLEYLAFFHEVEKIEFNKPRLHFITDTNLSGLICNYSFEFVVSIFRPPLTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQZ8</accession>
    <name>D7VQZ8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0167 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994547.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13402"/>
    <dbReference type="EnsemblBacteria" id="EFK56199">
        <property type="protein sequence ID" value="EFK56199"/>
        <property type="gene ID" value="HMPREF0766_13402"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZDCS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1433653_0_0_10"/>
    <dbReference type="OrthoDB" id="1896586at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005363">
        <property type="entry name" value="UPF0167"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03691">
        <property type="entry name" value="UPF0167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="189" mass="22166" checksum="D9AA97DE11A5E355" modified="2010-10-05" version="1">MGKIFELIADSALEILDSYYDECHVCNRTDIDLYAYQGKLHLENGEVDDDIYAACASCIAEGNLTHSCDFAYLEIIDRYLGLKNLDEEAYLQNKKMLAEKYQKTPDIPIFMQYEDRPLCCNDIAEFTGYPKDAEECYDLTEKALYWEKQVTVKSEFYNFRKYGPPESKRDIAFFCCTHCQTRYFTFQFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR46</accession>
    <name>D7VR46_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13450"/>
    <dbReference type="EnsemblBacteria" id="EFK56247">
        <property type="protein sequence ID" value="EFK56247"/>
        <property type="gene ID" value="HMPREF0766_13450"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3084854_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="52" mass="5964" checksum="60BDFCFAE832D9C8" modified="2010-10-05" version="1">MSLFRFARSGFKSVVRQLKSVIESLLYFDFTKQSGYKEAIKNRSAAKEIICA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR55</accession>
    <name>D7VR55_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994623.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13459"/>
    <dbReference type="EnsemblBacteria" id="EFK56256">
        <property type="protein sequence ID" value="EFK56256"/>
        <property type="gene ID" value="HMPREF0766_13459"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1593509_0_0_10"/>
    <dbReference type="OrthoDB" id="1705990at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107184" evidence="1">
        <location>
            <begin position="21"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="167" mass="18878" checksum="5EFD123232328A4A" modified="2010-10-05" version="1">MKTKSIFPALFITAVGAVWLSSCNGSSVDTVKSLESNYENQNKKIELTGEFDAPSFTFASSRSKTLGMHFVVKPHAISSEKFIVTDVVLPIGTDKNTVVMDIADDQKNYTLKDFYIYDKDGNKYNLDEHTQFKISGTVSYNELEKEESERRTDNFAYKLTDVTIEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRF6</accession>
    <name>D7VRF6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994751.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13560"/>
    <dbReference type="EnsemblBacteria" id="EFK56357">
        <property type="protein sequence ID" value="EFK56357"/>
        <property type="gene ID" value="HMPREF0766_13560"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066193_1_0_10"/>
    <dbReference type="OrthoDB" id="1757088at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="151"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="279" mass="31711" checksum="5F33F732B6879C37" modified="2010-10-05" version="1">MQVLPAEVLAPYIKHYLFLENVGDPHKTLRLFSDGNTGIVFLLEQVHLTTDHSQHLPSSFLYGQISNFQDLALTEQTSFIIIVFQPDGLYKLLGISARELKEQIVSTQDVFGQPAQKLYDSLRHLKQSTEKVNALNTFFYELAIQSESPGHTLLSSALQHITHHKGLVTVEQLVRYSGYTERHVERIFAEQVGMSPKKFGSIVQLHSFLKLLRTKTPETSLTTICYQSGYFDQSHLIKAFKKYTGITPTEYLNSTNRLAVNFMEFKEGPDAMSGLYNFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRK7</accession>
    <name>D7VRK7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome oxidase subunit II</fullName>
            <ecNumber evidence="8">1.10.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cydB</name>
        <name evidence="8" type="ORF">HMPREF0766_13611</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.-" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994816.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13611"/>
    <dbReference type="EnsemblBacteria" id="EFK56408">
        <property type="protein sequence ID" value="EFK56408"/>
        <property type="gene ID" value="HMPREF0766_13611"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1294">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049294_1_1_10"/>
    <dbReference type="OrthoDB" id="761975at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK56408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="337" mass="37853" checksum="DEE0592C4918AD56" modified="2010-10-05" version="1">MLYVVIAYLWAAICLYLILGGADFGAGIVELISGKETRPRVRSLMYKAIGPIWEANHMWLIIAIVILFVGFPEIYTTMSIYMHLPLLMMLIGIIARGTAFTFRNYDAVEDSMQTVYFRIFTISSLITPFFLGIIAASTVSSHIDTQATDFYTAYISSWFNWFGIAVGLFTVAICGYLASIFAIGQVEQKEDRRLMIRLAKLFVFVVMGCGVLVFAAAYYSHIPLLNWVLGDIWGQIAIFLASCSVIWLFISFRNESISLMRILAGFQVVMILFAATYKHYPNLILLKNGQHLSLVEHAGAEGAISSLAWALLLGSIFILPTLFYLMYSFSRKSIKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRP3</accession>
    <name>D7VRP3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994908.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13647"/>
    <dbReference type="EnsemblBacteria" id="EFK56444">
        <property type="protein sequence ID" value="EFK56444"/>
        <property type="gene ID" value="HMPREF0766_13647"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503393C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_911195_0_0_10"/>
    <dbReference type="OrthoDB" id="405111at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="311" mass="36612" checksum="00B3D110B07770D8" modified="2010-10-05" version="1">MLAKYWNCIVNMHITKEMNKLDIIQARIVNQIVFLKGTFFIVDSIRDWAFGLISNVFVLFSFGCLILSSFFFPKARFNPYIIFTACLTVSFLIFYYSSKDGFDNGITFYYFSQLTVVLLLLNRKSLIITFYLIIFILFCISHIYDFRLIKSDLIVTEPLIETVRIITFIQAFMLLSMAGYFIVFKHNELLRLYQQVLRSGTIISDLRKRLNDHQKINIEDIVKLAIDNDAAFIPLFKQNFPYFYDNLKSFNKQMTGEEFKFCALLKLGFTTKDIAEYNHFTVRTVQTKKNRLRKSFNIPSEKDLYAWIDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRU1</accession>
    <name>D7VRU1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56492">
        <property type="protein sequence ID" value="EFK56492"/>
        <property type="gene ID" value="HMPREF0766_13695"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3317196_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="39" mass="4708" checksum="732DF56B1E93E930" modified="2010-10-05" version="1">MEYPNYIHSYLCSLYYMDISYVNNLLLKDCAIVFDPNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRV1</accession>
    <name>D7VRV1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ThiF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hypB2</name>
        <name evidence="2" type="ORF">HMPREF0766_13705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995064.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13705"/>
    <dbReference type="EnsemblBacteria" id="EFK56502">
        <property type="protein sequence ID" value="EFK56502"/>
        <property type="gene ID" value="HMPREF0766_13705"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_4_1_10"/>
    <dbReference type="OrthoDB" id="1543144at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="PTHR43267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="11"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="240" mass="26131" checksum="A22CD795425DE80C" modified="2010-10-05" version="1">MKDLSWLSRTEALVGREALEKLASSHVMMLGLGGVGSYAAEFICRAGVGKMTIIDGDTVDPTNRNRQLPALSTNHGESKAEIMKERLMAINPELDLTVIQDFIIPEKIPALLDLKPDYCVEAIDSITPKLFFIRLALDAKVPFVSSMGAGGKVDPTKIKIADISQSYNCKLAQHIRKKLRKHGIRDGVKVAFSTELPDKNSLLYTDGSNFKKSAYGTMSYLPAAFGGAIASVAIRDLMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS12</accession>
    <name>D7VS12_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995213.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13766"/>
    <dbReference type="EnsemblBacteria" id="EFK56563">
        <property type="protein sequence ID" value="EFK56563"/>
        <property type="gene ID" value="HMPREF0766_13766"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032CSZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158631_0_0_10"/>
    <dbReference type="OrthoDB" id="1944542at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="132" mass="14956" checksum="6F096744F9DE5192" modified="2010-10-05" version="1">MTIIQSNTEINKSIAEVYLFLADFNNHEGLMPENIYNWSSTADEARFTIQNMAKLALKIDLRTPNEEIVAVPSEKAPFDLTLRWRLISISETETKANFVIEADLNMMMKMLASGPLQKLADHQTAKLKELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS17</accession>
    <name>D7VS17_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13771"/>
    <dbReference type="EnsemblBacteria" id="EFK56568">
        <property type="protein sequence ID" value="EFK56568"/>
        <property type="gene ID" value="HMPREF0766_13771"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3066344_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="59" mass="7030" checksum="33A001937C6028F3" modified="2010-10-05" version="1">MQGNNRVVHNFNKQCFKYMLQQFLTKSNVQKLFKIPGNREDSRLLFYLFLAKAIETCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS37</accession>
    <name>D7VS37_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M16 inactive domain protein</fullName>
            <ecNumber evidence="4">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13791</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995276.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13791"/>
    <dbReference type="EnsemblBacteria" id="EFK56588">
        <property type="protein sequence ID" value="EFK56588"/>
        <property type="gene ID" value="HMPREF0766_13791"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008156_0_0_10"/>
    <dbReference type="OrthoDB" id="1188251at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107612" evidence="1">
        <location>
            <begin position="23"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="68"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="228"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="705"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="956" mass="108097" checksum="4D614D5DCAD8BA8E" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS61</accession>
    <name>D7VS61_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, FAD/FMN-binding protein</fullName>
            <ecNumber evidence="2">1.3.1.42</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">opr</name>
        <name evidence="2" type="ORF">HMPREF0766_13815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.42" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995329.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13815"/>
    <dbReference type="EnsemblBacteria" id="EFK56612">
        <property type="protein sequence ID" value="EFK56612"/>
        <property type="gene ID" value="HMPREF0766_13815"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_0_1_10"/>
    <dbReference type="OrthoDB" id="1064766at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016629">
        <property type="term" value="F:12-oxophytodienoate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="PTHR22893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="5"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="366" mass="40748" checksum="30AADED7DFE24140" modified="2010-10-05" version="1">MSNNNLFQPFQLKSLHLKNRFVMAPMTRSFSPQGIPTSDVASYYGKRAAADVGLILSEGTVINRISSSNDPDVPHFYGHKALEGWQKVIQEVHQAGGSMGPQIWHMGIMPDHHSGWRPASPFEGPSAYNSPGLANGKAMTTDDIDAAIRAYGDAAAEAKRLGFDCVELHGAHGYLIDQFFWKATNNRTDSYGGETLAERSRFATEVIKEVRRRVGEDFAVIIRLSQWKPADYHYKLAQTPQEMEQWLLPLSEAGVDIFHCSQRRFWEPEFEGSDLNFAGWAKKITGKPTITVGSVGLDGEFLAAFAGESSQPSPLDELLRRYDRGDFDLVAVGRALLADPQWVQKIEQNQMDKLKGFSKEALAQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSA2</accession>
    <name>D7VSA2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995439.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13856"/>
    <dbReference type="EnsemblBacteria" id="EFK56653">
        <property type="protein sequence ID" value="EFK56653"/>
        <property type="gene ID" value="HMPREF0766_13856"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1249973_0_0_10"/>
    <dbReference type="OrthoDB" id="949367at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="221" mass="24747" checksum="D73ED836C7000826" modified="2010-10-05" version="1">MALAFDKNSRPFLDIKIAESTPFRVLFDSGSDKLLALSYLTYSELNKKREAKALYKGKGSVSSGLFGAGKEGEELRILLNQLEIGPGILDSIVTNVSENKNKNAIGMPVGKFGIITLDYLHKHFYFHPYQSRQVVTNGNFYGFDSQLVNDDYIASVVYEGSNAEKAGLKRGDIILQINEYKVDEFKDICQLFFGNYFTGESLNLTVKDKDNNIKTVKIAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSB2</accession>
    <name>D7VSB2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995462.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13866"/>
    <dbReference type="EnsemblBacteria" id="EFK56663">
        <property type="protein sequence ID" value="EFK56663"/>
        <property type="gene ID" value="HMPREF0766_13866"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2374">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058239_1_0_10"/>
    <dbReference type="OrthoDB" id="1387978at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19580">
        <property type="entry name" value="Exo_endo_phos_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="348" mass="39948" checksum="A54D8AC8A4D919C4" modified="2010-10-05" version="1">MMKKTYFRSLCILFIFVVQTHISVAQQKKYQVYAAAFYNLENLFDTEKDTLINDEEFTAEGGNRWTAEKYRRKQLNMAKVISRLGKKYCPAGPAFVGLCELENRKVLEDLTQQPSLVSLGYGIVHYDSPDRRGVDVALLYNPSLFKVKDSKVFAYKVDHLPEYRTRDILLVTGELAGEEMHVLVNHWPSRYGGKSSELREHAASIVRSVVDSLYAQDSLAKVVIMGDLNDDPVDKSVRIVLNAKKTQQEVAKGGLFNTMWQHYERGVGSLGYQGKWNLFDQIIISEPLLGEDRSTLKFWKSEIYNPEFLITQEGRYKGYPFRTFSGNVFQNGYSDHFPTLIYLVKDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSD8</accession>
    <name>D7VSD8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995518.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13892"/>
    <dbReference type="EnsemblBacteria" id="EFK56689">
        <property type="protein sequence ID" value="EFK56689"/>
        <property type="gene ID" value="HMPREF0766_13892"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50332VZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_969453_0_0_10"/>
    <dbReference type="OrthoDB" id="1173009at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025409">
        <property type="entry name" value="DUF4303"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14136">
        <property type="entry name" value="DUF4303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="287" mass="33078" checksum="DF3D9CFED04ECE04" modified="2010-10-05" version="1">MSKSNNKIKLSEEEALKIIVDLDQIVVSLDKIKSHFAEDSDFQKHDKILSDYIINEQVNQTLAQIRGLLSSKFSLIVGEDDMDDLERACSTNRYWCPESKETAVPTNPENWHERNLPVLSGSIINEFDFFYQLFRKNKQSMYAFALILDDDCLSAYSAVSTIESLNKIHKNKEWDASEWCFCVSQGAVKEGVDTFTRLLLDRYRKDIVPLFQQGFDYAPERQKNLQLFTDAMRIAKQELVKKYGNEIEEMAFYLSIPGEPIVEKNSVLAINNEGNTKVKELLDSLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSH8</accession>
    <name>D7VSH8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">L-fucose:H+ symporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fucP</name>
        <name evidence="14" type="ORF">HMPREF0766_13932</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Intake of glucose and galactose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995585.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13932"/>
    <dbReference type="EnsemblBacteria" id="EFK56729">
        <property type="protein sequence ID" value="EFK56729"/>
        <property type="gene ID" value="HMPREF0766_13932"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028452_0_1_10"/>
    <dbReference type="OrthoDB" id="1121832at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015535">
        <property type="term" value="F:fucose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005354">
        <property type="term" value="F:galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005355">
        <property type="term" value="F:glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005964">
        <property type="entry name" value="Glc/Gal_transptr_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005275">
        <property type="entry name" value="Lfuc_symporter_FucP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00885">
        <property type="entry name" value="fucP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01272">
        <property type="entry name" value="gluP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="13">
        <location>
            <begin position="10"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFK56729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="421" mass="45871" checksum="57D175557A7E435D" modified="2010-10-05" version="1">MTKTKSYSLALVLVTSLFFFWGFIHNLDPILIPHLRMAFSLTTFQASLVDSAVFIAYFVMAIPAGLLMKKYGYKSGILIGLIFFALGCFLFVPAANTMSYVFFLGALFVVACGLTILETAANPYVTVLGDPSTATQRLNFAQSFNGLAAFVAPILGGKYILTEEPKSAEELAALSEQARNAYLQVETSSVKLPYVILGVLILVVAAIFYFTRLPDIKDDEEKTKSGFFHAFKHKNVSWAVLAQFFYVGAQVCILSFLVLFATDAAGIPPQEAKYYAGVAGLAFMLGRFVGTFFMKYVSAPKLLAIYSVISILLSFVVIFGSGVITLYALIGISFFMSIMFPTIFAIGVQGIGSDTKSASSLIVMSIVGGAILPPILGYISDHTGHLQYGYFVPLVCFVVVLLFAMKNNKLVIEETEDIKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSH9</accession>
    <name>D7VSH9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mltR</name>
        <name evidence="5" type="ORF">HMPREF0766_13933</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995586.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13933"/>
    <dbReference type="EnsemblBacteria" id="EFK56730">
        <property type="protein sequence ID" value="EFK56730"/>
        <property type="gene ID" value="HMPREF0766_13933"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_3_10"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="183"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="284" mass="32870" checksum="70F069C42D9255C2" modified="2010-10-05" version="1">MKPQLLTLGTPSAASFSIRNDVKPQQHNNWHYHEELELIHIAKGSGTQFVGDSINNFENDNMVLLGSNLPHYWLFDEQYLQDNADIRVAHFRENFLGDVFFNLPENRKLKELFSKAKQGLLIYGGTRDILRQLLEKLISATGASRIIILLEALNVLATSDEYERLTRSTYEFQNHLGDHDRLNAIIQYATQHYRNKISLAELAQIIGMTENSFCRFFKSKTGKTPIEFITELRIGHASRLLIEQEMPVKQICFESGFQNFVSFHKAFRKIKETTPLMYQKSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSI9</accession>
    <name>D7VSI9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995596.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13943"/>
    <dbReference type="EnsemblBacteria" id="EFK56740">
        <property type="protein sequence ID" value="EFK56740"/>
        <property type="gene ID" value="HMPREF0766_13943"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015077_0_0_10"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107535" description="Peptidase_M1 domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="2">
        <location>
            <begin position="400"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="652" mass="73584" checksum="6BB050E07ABD33FB" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSM1</accession>
    <name>D7VSM1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pirin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sdr</name>
        <name evidence="5" type="ORF">HMPREF0766_13975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995639.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13975"/>
    <dbReference type="EnsemblBacteria" id="EFK56772">
        <property type="protein sequence ID" value="EFK56772"/>
        <property type="gene ID" value="HMPREF0766_13975"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045717_5_1_10"/>
    <dbReference type="OrthoDB" id="833478at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="34"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="4">
        <location>
            <begin position="187"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="291" mass="31823" checksum="E7573E104C9E3E35" modified="2010-10-05" version="1">MSTRTIETVIAPQGAHFVGDGFRVHNFIPGIAPLSMQRMSPFLLLDYNAPYIFPPSDKIKGVGVHPHKGFETVTIAYKGRVAHHDSSGGGGVIDAGDVQWMTAASGILHKEYHEESFSKSGGEFQMVQLWVNLPAKDKKTNPKYQAITNADMTRVPLNNEGSYVEVIAGTYKGHDGPATTFTPVNLMNAHLKKGGKANFSFPAHYNTAVLIIEGAVTVNGTAVDTDNFVLFKNNGEEFDVEAKEDAVVLVLSGQPIEEPIFAHGPFVMNTREEIMEAFDDYNKGKFGYLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSY4</accession>
    <name>D7VSY4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995881.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14088"/>
    <dbReference type="EnsemblBacteria" id="EFK56885">
        <property type="protein sequence ID" value="EFK56885"/>
        <property type="gene ID" value="HMPREF0766_14088"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZBNJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106197_0_0_10"/>
    <dbReference type="OrthoDB" id="1341663at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107902" evidence="1">
        <location>
            <begin position="20"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="206" mass="22957" checksum="BEE4B64A1F3A4906" modified="2010-10-05" version="1">MKKLIALVLIALTSGIVVNAQQKPVREPLPADVQVRIAVQAAPTEFREGAKVYGYDKDGKFTVLREGTNGYICLAPDYKLPLLYAYAYPESLEPFMARGRALIAEGKRKERDKIREEEFKAGKLSIPQQPTMLYGYWGSLDKLDKETGEMADAKRRYVLYVPYAKAADLGLASKPTVPGIPWLMDEGSYKAHIMINPADMGHSHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT13</accession>
    <name>D7VT13_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995950.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56914">
        <property type="protein sequence ID" value="EFK56914"/>
        <property type="gene ID" value="HMPREF0766_14117"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115867_0_0_10"/>
    <dbReference type="OrthoDB" id="1550820at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="205" mass="23036" checksum="BC00952037651E78" modified="2010-10-05" version="1">MISNAYSQAQTRVEDYIITMQGDTLYGKIRSLKDNKLRFESKNGIKVYKPAEVSRAYNASGNKIYASSSVQSTMEKTAVVKPVFAELIQEGEIAIYAFEKVYNGSPRHRNYGVGNRGTVMGPTASISVKYYAVKKSTGEIVEIANSGMDLFGKQTKKRAENLLKLIEDEAVLSQSLAREKSYNQDVFIRYIADYNKLKISQRNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTC5</accession>
    <name>D7VTC5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_14229</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996241.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14229"/>
    <dbReference type="EnsemblBacteria" id="EFK57026">
        <property type="protein sequence ID" value="EFK57026"/>
        <property type="gene ID" value="HMPREF0766_14229"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_1_3_10"/>
    <dbReference type="OrthoDB" id="554994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="20"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="372"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="529" mass="59168" checksum="CF60110740AE344D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTS0</accession>
    <name>D7VTS0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase, S9A/B/C family, catalytic domain protein</fullName>
            <ecNumber evidence="3">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002195.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14390"/>
    <dbReference type="EnsemblBacteria" id="EFK55699">
        <property type="protein sequence ID" value="EFK55699"/>
        <property type="gene ID" value="HMPREF0766_14390"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_3_1_10"/>
    <dbReference type="OrthoDB" id="154149at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="417"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK55699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="629" mass="71642" checksum="C97A74FE49A45D91" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTZ5</accession>
    <name>D7VTZ5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002318.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14465"/>
    <dbReference type="EnsemblBacteria" id="EFK55774">
        <property type="protein sequence ID" value="EFK55774"/>
        <property type="gene ID" value="HMPREF0766_14465"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1255302_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107598" evidence="1">
        <location>
            <begin position="21"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="220" mass="26239" checksum="7376AE85FDF484FB" modified="2010-10-05" version="1">MKVFNIIILMNIFLFGPLQAQTKLDTCQDIILKGYVITQYKRSDIKSIKNVASHMIDFYHREYFIPLKNNLDQVTIDSINVFNPDEVYFLPSNETYRLMIKYCNKYKNKESYFSTKVDLNSFFKVGKKNSEFLYKIYYYECKAVKSEIANNSLNAFQLNVPFKKESKFLNCYFIYQNVIMQEIKRINSENFYRVKRSSEINANMEQDDTHQPSGGWMCDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGB7</accession>
    <name>D7VGB7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 4</fullName>
            <shortName evidence="5">EF-4</shortName>
            <ecNumber evidence="5">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">lepA</name>
        <name evidence="7" type="ORF">HMPREF0766_10036</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001913.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10036"/>
    <dbReference type="EnsemblBacteria" id="EFK60092">
        <property type="protein sequence ID" value="EFK60092"/>
        <property type="gene ID" value="HMPREF0766_10036"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009995_3_3_10"/>
    <dbReference type="OrthoDB" id="182107at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="2"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK60092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="596" mass="66998" checksum="316514868E9C3F4F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGB9</accession>
    <name>D7VGB9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001917.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10038"/>
    <dbReference type="EnsemblBacteria" id="EFK60094">
        <property type="protein sequence ID" value="EFK60094"/>
        <property type="gene ID" value="HMPREF0766_10038"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032RYU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1554310_0_0_10"/>
    <dbReference type="OrthoDB" id="2085803at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="172" mass="17806" checksum="B0763373C0C6567B" modified="2010-10-05" version="1">MKKIALLAVVATALTMASCNNSSNQHAGHDHADHDSITAGDHVDAAIADLQKAEADAKAKAEQAKKDLDDAIARGDKKAEEAARKASEEANTAWEKTKTALKDAGQDIKEGLDKAADATGKATSDAVEATKDGANKAITETKEAAEKVGDATKKAASDVENKAKKVGEALKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGI7</accession>
    <name>D7VGI7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_10106</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002069.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10106"/>
    <dbReference type="EnsemblBacteria" id="EFK60162">
        <property type="protein sequence ID" value="EFK60162"/>
        <property type="gene ID" value="HMPREF0766_10106"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002934_0_1_10"/>
    <dbReference type="OrthoDB" id="439010at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107157" evidence="5">
        <location>
            <begin position="26"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK60162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="502" mass="57875" checksum="33B9D6401D5AD26A" modified="2010-10-05" version="1">MNMKNKLYMVLLAGAGLLSTLSAEAQWTGPKEKPKERIEVKYGPLTPAHRTDEAMERFRQYGLGQFIHWGLYAIPGNEWEGVSARGGAPASEWIRTWGGTTAPKDWKNTYDNLYKQFNPKGFDARQWAKQAKDMGARYVIFTTKHHDGFALWPTKYTDYNITKSPYKKDIVKQVVDAYTAEGIDVYLYFSILEWNNPDYMGKEPKTEEEKAKYAKFLNYTKNQLLELLKNYPQIKGFWFDGTWDQSWIKSYDFTYKLEKELREKHPGLIIGSRFRNDEFGKRHFDSNGDMLGDYEQGWERKLPEEYSWLEGRDWDCVMTIPPNGWGYMKDWTGLYTKTSDDLIDMLMHSVSMGGNFVLNFGPDGNGKMHPGEDKLAKELGDWMKINSEAVYGVKYAGLSPSKYGYFTRKNEQVYLTVFNRPVNNIVRIAIDKKATEIPASASLLINGQSLVLKRSDIGLDLDKNAYFDVILPKDFQSDKPFVIKISTVKGDIKTDKLMDAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGK6</accession>
    <name>D7VGK6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_34 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996645.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10125"/>
    <dbReference type="EnsemblBacteria" id="EFK59208">
        <property type="protein sequence ID" value="EFK59208"/>
        <property type="gene ID" value="HMPREF0766_10125"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142189_1_1_10"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027395">
        <property type="entry name" value="WH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13601">
        <property type="entry name" value="HTH_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_34" evidence="1">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="100" mass="11661" checksum="DDD3DB77B315B098" modified="2010-10-05" version="1">MNINLDLYDKTLENKVRLQIMSVLVANLEYDFSSLKMLLDVTDGNLASNLKTLEKEGYIEVFKTFIDRKPNTRYRKTTKGQAAFENHLTALENLIKQQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGR4</accession>
    <name>D7VGR4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-glutamate methylesterase CheB</fullName>
            <ecNumber evidence="3">3.1.1.61</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheB</name>
        <name evidence="3" type="ORF">HMPREF0766_10183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.61" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996810.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10183"/>
    <dbReference type="EnsemblBacteria" id="EFK59266">
        <property type="protein sequence ID" value="EFK59266"/>
        <property type="gene ID" value="HMPREF0766_10183"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_51_2_10"/>
    <dbReference type="OrthoDB" id="1655418at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheB-type methylesterase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="193" mass="21145" checksum="F98C83D7146C39C9" modified="2010-10-05" version="1">MNQPKIIILAGSAGSYSVLVEILKYLPADMSIPVIVILHRNAKYETNIESSLSKKCKIEVKIAEDKEKIQTGVAYFAPPGYHLLVEPDYTFSLDSSEPVQFCRPSIDVTMESAADVYQSGTCGFLFSGANQDGADGLAYIKKINGTCIVQNPAVAEISTMPESAIKLGAYHRIMDNKGIIDFILDLHKQNIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGV1</accession>
    <name>D7VGV1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996905.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10220"/>
    <dbReference type="EnsemblBacteria" id="EFK59303">
        <property type="protein sequence ID" value="EFK59303"/>
        <property type="gene ID" value="HMPREF0766_10220"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032Z4I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_193614_0_0_10"/>
    <dbReference type="OrthoDB" id="1970000at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="75" mass="8348" checksum="52381156869A0F0C" modified="2010-10-05" version="1">METVKKLLGIVWIALALFTAYFCIFELAIPKIGTGHQEDLVFGIIILAVLTPIISVGLALFGYFAWTGEYHTEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH20</accession>
    <name>D7VH20_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10289</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997098.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10289"/>
    <dbReference type="EnsemblBacteria" id="EFK59372">
        <property type="protein sequence ID" value="EFK59372"/>
        <property type="gene ID" value="HMPREF0766_10289"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039620_0_0_10"/>
    <dbReference type="OrthoDB" id="1147116at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016715">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036939">
        <property type="entry name" value="Cu2_ascorb_mOase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="SSF49742"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106891" evidence="3">
        <location>
            <begin position="25"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="437" mass="50513" checksum="F7B80009D42AD603" modified="2010-10-05" version="1">MKLKFLYFLNLFLLTLLSVQNISAQTYQDVRQILINKCASCHKSTDSEAPFSLETYQDVKKRTRMIKEVIQSNYMPPWMPDSHYQDFANNRQLSGEEKDKIIKWIDKGAPQGNKKQQNTLSKTTSPIDRKPDLTLKINKPFIVKGNNKERFVLFKVPFELLEDKNIEGVEFYSDNKKVVHHVNYMFSSVPDISVNLYQGDPYIDNAEETDMKKLMQYEPFQNRPVFYTGWIPGASIEYYPKDFGWTLPKRGVVIFTVHYSATAADEQSTIGVNLYFKKTPAKRPVRIISLGSGGIGEKDIYPRFVIPPDQESTFSLKIRTPEDQSLLYVWPHMHYLGKDFKAFAVTLHNDTIPLIHIPKWNFEWQEMYRMKKLVKVPAGSTINIVGTFDNTANNPQNPNSPPKYVYSTGNMTSTDEMLTFLLIYAPYQSGDEEILLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH58</accession>
    <name>D7VH58_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease Z</fullName>
            <shortName evidence="8">RNase Z</shortName>
            <ecNumber evidence="8">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">rnz</name>
        <name evidence="10" type="ORF">HMPREF0766_10327</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997176.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10327"/>
    <dbReference type="EnsemblBacteria" id="EFK59410">
        <property type="protein sequence ID" value="EFK59410"/>
        <property type="gene ID" value="HMPREF0766_10327"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_2_1_10"/>
    <dbReference type="OrthoDB" id="1712770at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02651">
        <property type="entry name" value="RNase_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="9">
        <location>
            <begin position="33"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="9">
        <location>
            <begin position="202"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK59410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="303" mass="34319" checksum="DC052E148CFA3A6E" modified="2010-10-05" version="1">MKFEVLILGNSSATPMYERHPSSQLLNFNEQFFLIDCGEGTQMQLFRYGIRSNRIGHIFISHLHGDHYLGLVGLLSSMHLVGRKSGLHLYGPAPLKEILDVQFRHSDTQLRYNLIFHPTNPDKEEVILETAAFKVSTFPLTHRIPCTGFRFDEGKRSPAIIAELVEQLNIPKQYIGGIKRGLDYTAPDGKVYKAAELTIPPPPSRSYAYCSDTVRVPDYIAAISNVDLLYHESTFLHEMVERAKETLHTTAQEAAEIAKEAGAHKLLLGHYSARYRELQPLLEEAQHVFKNTQLSVEGKWFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH76</accession>
    <name>D7VH76_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase</fullName>
            <ecNumber evidence="3">2.5.1.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hepT</name>
        <name evidence="3" type="ORF">HMPREF0766_10345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.30" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997214.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10345"/>
    <dbReference type="EnsemblBacteria" id="EFK59428">
        <property type="protein sequence ID" value="EFK59428"/>
        <property type="gene ID" value="HMPREF0766_10345"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_0_10"/>
    <dbReference type="OrthoDB" id="1861068at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036422">
        <property type="term" value="F:heptaprenyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="323" mass="36425" checksum="32102ACE652F2E5C" modified="2010-10-05" version="1">MLKLNDIQKPIANELAAFEHKFKASMQSSVPLLDRITHYIVKRKGKQMRPMFVFFSAGLCGSINESTFRGASLVELLHTASLVHDDVVDNANERRGFFSVNALWKNKVAVLVGDFLLSKGLLLSVDNNDFHLLKIVSEAVEQMSEGELLQIEKARKLDIEESVYFEVIRQKTASLIASCCACGAASTDVDEETVKKMHAFGEKVGIAFQIKDDLFDFGLDDVGKPLGNDIKEKKMTLPLIYALSQTDKSEKRRIINLVKNHNEDNKKVAEVIAFVRSSGGLDYATEKMFQYQQEAFEILNSFPEGIYRTGLEQLVRYTTERKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHG3</accession>
    <name>D7VHG3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-succinylornithine carbamoyltransferase</fullName>
            <ecNumber evidence="2">2.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">N-succinyl-L-ornithine transcarbamylase</fullName>
            <shortName evidence="2">SOTCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">argF</name>
        <name evidence="2" type="synonym">argF'</name>
        <name evidence="6" type="ORF">HMPREF0766_10432</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the carbamoyl group from carbamoyl phosphate to the delta-amino group of N(2)-succinyl-L-ornithine to produce N(2)-succinyl-L-citrulline. Is essential for arginine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>carbamoyl phosphate + N(2)-succinyl-L-ornithine = H(+) + N(2)-succinyl-L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25884"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58514"/>
            <dbReference type="ChEBI" id="CHEBI:58862"/>
            <dbReference type="EC" id="2.1.3.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. SOTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.11" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997434.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10432"/>
    <dbReference type="EnsemblBacteria" id="EFK59515">
        <property type="protein sequence ID" value="EFK59515"/>
        <property type="gene ID" value="HMPREF0766_10432"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_3_3_10"/>
    <dbReference type="OrthoDB" id="988597at2"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02235">
        <property type="entry name" value="SOTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043696">
        <property type="entry name" value="ArgF'-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="4">
        <location>
            <begin position="202"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="2">
        <location>
            <begin position="47"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="2">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="2">
        <location>
            <begin position="277"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>N(2)-succinyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:58514"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>N(2)-succinyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:58514"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>N(2)-succinyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:58514"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>N(2)-succinyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:58514"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK59515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="322" mass="36400" checksum="5A2ACAACECB970EE" modified="2010-10-05" version="1">MNKFFSVDDIPNLSEAVKEALALKANPNANEDLGKHKTLGLVFLNPSLRTRLSTQKAAMNLGMNVMVMNMDKDGWALETQDGVVMNGTTVEHIREAAAVMGEYCDILGLRSFPKLKDRKEDYSEDLFSKFMKYCAVPVVSLESATRHPLQSLTDLITIVEHWNKPGKPKVVLTWAPHVKALPQAVPNSFAEWMCRAQEEGLLDFTVVQPEGYQLAKEFTEGATISTNLKESLQDADFVYVKNWSSYEDYGKVYPIEEDWMMDNKKLKLTNDAKVMHCLPVRRDLELSSEILDGPNSLVIKEASNRVWAAQVVIKRMLENLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHL2</accession>
    <name>D7VHL2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulatory protein RprY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rprY</name>
        <name evidence="6" type="ORF">HMPREF0766_10481</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997537.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10481"/>
    <dbReference type="EnsemblBacteria" id="EFK59564">
        <property type="protein sequence ID" value="EFK59564"/>
        <property type="gene ID" value="HMPREF0766_10481"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_3_10"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="133"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="133"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK59564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="231" mass="26728" checksum="88BF07FCD3060776" modified="2010-10-05" version="1">MQIMQKILLAEDDPNLGELLKDYLELKGKFDVTLCQDGEEALVAFHKDQYDLCILDVMMPKKDGFSLGKDIRKTNTTVPVIYATAKGMMEDKTQAFELGGDDYITKPFRVEELLLRINALLKRSSRDKDEETADKFEIGDYFFDYTSQQISYKGQQQKLSTKEAELLRLLCLKKNDVLTREEALLKIWHDDNYFTGRSMDVFLSKLRKYLREDPSVEIVNVHGKGYKLLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHN6</accession>
    <name>D7VHN6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997582.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10505"/>
    <dbReference type="EnsemblBacteria" id="EFK59588">
        <property type="protein sequence ID" value="EFK59588"/>
        <property type="gene ID" value="HMPREF0766_10505"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_10_0_10"/>
    <dbReference type="OrthoDB" id="1592010at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="53"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="390" mass="43903" checksum="0BE7DA38C4C8D02A" modified="2010-10-05" version="1">MVKYYSGDYVLPITNLPIKRGVVAIDASGVIQGVYANDAVELVGKKIELLNGVLIPGFINAHCHIELSYLKGAIAQRTGLPQFISAVMSSRKENEKTVVKHIEKADKLMYDNGIQAVGDHVNTSFSAAVKERSSIKYHTFVEAMGLNKEQVESRLEEAQETRYHFNDTHSSITPHAPYSCSKLLLKAFKKLTTGDSLISIHNQESEAENKLFRYKQGEFLKFYEQIGYNIADFKAQARNSIQSYLPNLPVRNKLMLVHNTYTSLKDLDFVRRMDREVVWCFCPKANLYIEGALPKVMNFVNDDQKIVLGTDSFASNDTLDILEELKVLHEAFPALEFTKTINWATINGAEFLNFDDKLGSLEVGKKPGLILLEGMENLRLTSNVTVQRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHR7</accession>
    <name>D7VHR7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">efp</name>
        <name evidence="11" type="ORF">HMPREF0766_10536</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the elongation factor P family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997665.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10536"/>
    <dbReference type="EnsemblBacteria" id="EFK59619">
        <property type="protein sequence ID" value="EFK59619"/>
        <property type="gene ID" value="HMPREF0766_10536"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074944_0_1_10"/>
    <dbReference type="OrthoDB" id="1260763at2"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="10">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="9">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK59619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="186" mass="21079" checksum="E7126075643FD7D4" modified="2010-10-05" version="1">MAKASDVKSGNVLRFNGELVAVEEYIHRTPGNLRAFYQARMRNVKTGKLVEYRFRVDEAVEIARVETNDYQYLYEDGEFYVVMDNSTYEQFNIPKFLFGTSARFLKEGMSVIVAFESDEAIMAQAPKSVELEITYTEPAVKGDTSTNALKNATVETGVEIKVPLFINQGDKVKVDTQSGEYIERVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHT1</accession>
    <name>D7VHT1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alanine dehydrogenase</fullName>
            <ecNumber evidence="2">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ald</name>
        <name evidence="6" type="ORF">HMPREF0766_10550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997700.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10550"/>
    <dbReference type="EnsemblBacteria" id="EFK59633">
        <property type="protein sequence ID" value="EFK59633"/>
        <property type="gene ID" value="HMPREF0766_10550"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003376_3_0_10"/>
    <dbReference type="OrthoDB" id="673280at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05305">
        <property type="entry name" value="L-AlaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008141">
        <property type="entry name" value="Ala_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795">
        <property type="entry name" value="PTHR42795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="5">
        <location>
            <begin position="32"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="4">
        <location>
            <begin position="177"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK59633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="403" mass="43493" checksum="470EDD4F7676636D" modified="2010-10-05" version="1">MGSISKIAQQAMMQPQEALMAVGKSKNSLTIGIPKEVSFQENRIALTPLSVALLIENGHKVILESNAGAGSNFLDQHYSEQGALIVYSSEEVYKADLIIKVASPTLEEVSLMKTGQVLFSSQQPSMMDLAVLQSLIKKKVTALSYEYLQDEGCHLTVVRAMSEIVGATAVLIAAEYLSNVFDGKGLMLGGVTGVPPTEMVIIGAGTVGEFAARTAIALGAQVKVFDSSVYRLRRLQNNVGSRVFTSVIQPIVLNKAVRSCDVVIGALRAVNGRSPCIISEETVSQMKPNSVLIDVSIDQGGCFETSEVTSHDKPVFRKYDVIHYCVPNIASRVARTATYALTNIFSPILLQIGEAGGMNKMIWANQGIRSAIYLYQGNLTNKDMANKFNLPAKDLDLIIVSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHV7</accession>
    <name>D7VHV7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10576</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10576"/>
    <dbReference type="EnsemblBacteria" id="EFK59659">
        <property type="protein sequence ID" value="EFK59659"/>
        <property type="gene ID" value="HMPREF0766_10576"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_631505_0_0_10"/>
    <dbReference type="OrthoDB" id="1245649at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107149" evidence="3">
        <location>
            <begin position="19"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="429" mass="49959" checksum="11DADECEF60F05C6" modified="2010-10-05" version="1">MKLILTYILMMTLSSVFAQYSKEDSIRMEALETQIENASQQQDNVLKARLYEELLQIAPKNGRYLNNAGATYFYLKDYQKAKEKFRMAVLYAPEKQALYFTNLSAAFAKIEDWERAYDYARRALETEETDLTLFNAASHANNAGKANACIQILDNARIPLPADVQSLYARSYMTLGDPTKAIEHYELFFRSYDITTAVAKDINMDDERSNLYQSYLYEISLKAYKNIPMDPDWQRMTDLYITLMNTAHKREITWTGTLNRMNEILPLRPAYKKNFESLIYAYPGLSEEEKICGKYMLKDKVQAEAMAQNWMRNNPKTQDYAQNQRIRRIIFYLALDEYLSQWNKSKQHNRSLLAELTALFSSIFDAEKLHTDTAHLLQDDFLTLTFQEIAKKLKQTFANRKDALPLIKGFINALPDSQAKTEMIREIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI23</accession>
    <name>D7VI23_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997916.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10642"/>
    <dbReference type="EnsemblBacteria" id="EFK59725">
        <property type="protein sequence ID" value="EFK59725"/>
        <property type="gene ID" value="HMPREF0766_10642"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049141_0_0_10"/>
    <dbReference type="OrthoDB" id="1387978at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="343" mass="38925" checksum="E9299BD43C0968FB" modified="2010-10-05" version="1">MRKIFLLLQFFFTVAVWGQESKNLRVLQFNIWQEGTVVPGGFEAIANEIARLKPDLIAFSEVRNYHDTKFNERIVEALAQRGLTYYSFFSNDSGLLSRYPLISYGRVGDDSKFKGTIHKAVVSPSEGKTIAFYTAHLEYTKGANYLPRGYHADTWAKLEAPIVDADAVLANNNSSSRDEAIQIFMEDAAKEISVGHEVILGGDFNEPSYLDWTARTKDKYDHKGLIITWTITKMLAEGGFQDAFRKVYPDEVTHPGFTFPSYNKDVEISKLVWGASADERDRIDFIFYKSGQRLKPVKAAVVGPKESILRGEKTTEISKDKFILPLAVWPTDHKALLIDFQWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI76</accession>
    <name>D7VI76_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pectate_lyase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998021.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10695"/>
    <dbReference type="EnsemblBacteria" id="EFK59778">
        <property type="protein sequence ID" value="EFK59778"/>
        <property type="gene ID" value="HMPREF0766_10695"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50348KW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_594351_0_0_10"/>
    <dbReference type="OrthoDB" id="271577at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="Pectate_lyase_SF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pectate_lyase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pectate_lyase_3" evidence="1">
        <location>
            <begin position="33"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="460" mass="51773" checksum="F03917D997BFA4BB" modified="2010-10-05" version="1">MMKKKELLIRYNLLLLIFIVFPYLIVYGEDTNFVNVLDYGAKGDGRTDDTHAFRKAAETRKNIIVPNTGKPYSISGRIRLYSSIKGEGNPTIKMDINKVNSFVMPESYKYGKFTVFHIGNYQANDPLYIEGLTIDGGWNGKHFGSEYEAGIYIASSKNIIIRNNVIKNTLGDNILLYWYNSSYEKNTKNFCDNILIEDNKLYNPYRCNVAVVSGKNITIRGNSIHKENEHVAAIDLEMDVWEKDGQVVQNINIYNNNIQAIKTKYVISTLGMRNGANIITIKDNEIVGSTKDGGIGVNFDAAYGPIEGINVVRNKIDADLFVRLMGTFGNKNVVIAENKSFSSTQHSVIVNGSYINGLSINNNESVVSKNFYSNIILGKNVQRVSIFSNNFSSLNWSSMFFVADINGLDIYDNTIKSKDVPIYFEPAGDNQIKNIRIFKNRTKASTIFKTTKKLSKLNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI89</accession>
    <name>D7VI89_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 5">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rfbB</name>
        <name evidence="7" type="ORF">HMPREF0766_10708</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 5"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998048.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10708"/>
    <dbReference type="EnsemblBacteria" id="EFK59791">
        <property type="protein sequence ID" value="EFK59791"/>
        <property type="gene ID" value="HMPREF0766_10708"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_14_10"/>
    <dbReference type="OrthoDB" id="707977at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="6">
        <location>
            <begin position="6"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="349" mass="39626" checksum="C44B01E9924393D3" modified="2010-10-05" version="1">MNKTIIITGGAGFIGSHVVREFVIKYPDYHIVNLDALTYAGNLENLKDVQDRSNYKFVKADITDANHIIEIFKNYQPDGVIHLAAESHVDRSISDPTAFVMTNVIGTVNLLNAAKEIWRDNYEGKRFHHVSTDEVFGALGSTGLFTEDTKYDPHSPYSASKASSDHFVRAYHDTYGLPIVLTNCSNNYGPNHFPEKLIPLCIHNILNNKPLPIYGDGKYTRDWLFVIDHAKAIDLVYHQGKSGESYNVGGFNEWQNIDLVKELCKQMDEKLGKPAGTADQLITYVKDRPGHDLRYAIDATKINQELGYQPSVTFEEGLSVTIDWFLNNQDWLDNVTSGDYQKYYEEQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI91</accession>
    <name>D7VI91_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pmi2</name>
        <name evidence="3" type="ORF">HMPREF0766_10710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998051.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10710"/>
    <dbReference type="EnsemblBacteria" id="EFK59793">
        <property type="protein sequence ID" value="EFK59793"/>
        <property type="gene ID" value="HMPREF0766_10710"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0836">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035527_0_1_10"/>
    <dbReference type="OrthoDB" id="224217at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005976">
        <property type="term" value="P:polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="MannoseP_isomer" evidence="2">
        <location>
            <begin position="291"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="332" mass="37729" checksum="3C5F964BFCF67E26" modified="2010-10-05" version="1">MSNIVHVILSGGVGSRLWPLSRKSYPKQYLSLFKEGSLFEMTVNRNQTLADQVIVVGNRDNHQLSREVMENNGIQYIDIVESTPRNTAAAIAFAAFAAKSDDILIVTPSDHVIVGEQAYEESMKKGIEKASQGYIVTFGIQATRPETGYGYIEYQGDQVISFREKPNQDTAEDFIERGNFLWNSGMFCFRADTFLQELQQFEPKVYATALAAWKHRKDNLLDEQLSKEIPAISIDYAVMERSKKIRVVATHFNWSDLGSFESMYDYLKQTGHPVDENGNMVIGTDTYTAFVGLKNTILVYTKDAFLILQKEKSQDVKKIYNTLERHQSKLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIQ3</accession>
    <name>D7VIQ3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998376.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10872"/>
    <dbReference type="EnsemblBacteria" id="EFK59955">
        <property type="protein sequence ID" value="EFK59955"/>
        <property type="gene ID" value="HMPREF0766_10872"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_5_10"/>
    <dbReference type="OrthoDB" id="1498685at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="255" mass="28915" checksum="AA682A20ED616A93" modified="2010-10-05" version="1">MQFITISTEERITHITLDRGKSNAMHMEMIDELTQAILEAEEDPAIEGIILHGKENFFTSGLDLITLYQYNEEQMKIFWSRFMTLIHTLTSFSKPSVAAISGHSPAGGCVLGICCDYRVMARGEFIIGLNEVPVGIVVPPSIFKLYSFWIGQRLAYQYLLEGKLLNPEKALEVGLIDEVVDPDRIRTAALRKIKSVTQFEKNSWRSTKQNLRKELLESITQQQEAAIDQVLKQWWAPATRAVLKTIIENLTAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIT6</accession>
    <name>D7VIT6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
            <ecNumber evidence="2">3.4.17.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ammA</name>
        <name evidence="2" type="ORF">HMPREF0766_10905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10905"/>
    <dbReference type="EnsemblBacteria" id="EFK59988">
        <property type="protein sequence ID" value="EFK59988"/>
        <property type="gene ID" value="HMPREF0766_10905"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023257_0_1_10"/>
    <dbReference type="OrthoDB" id="796259at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="195"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="396" mass="43937" checksum="2205F0AE8C78E7D2" modified="2010-10-05" version="1">MTISKEQVQQLSEEFLNDIIAIRRHLHQHPELSFEEYNTSAFIQDQLRQLDIPFTTMANTGVVALVKGDLPGEEVIALRADIDALPIQEVEGRAYGSSNQGVMHACGHDAHTSSLLGVARILHRLKSTFSGTVKLIFQPGEERLPGGASLMIKEGVLHNPEPKSIIGQHVMPFIETGKVGFREGKYMASCDELFMTVRGRGGHGAHPHQNIDPIVITAHIITALQQVVSRMADPRTPTVLSWGKVQANGATNIVPNEVYLEGTFRTFDEKWRAEAHEKMIKMAVGIAESMDAVCDFEVRKGYPFLINDELTTRQARLLAEDYLGKENVVDLDLWPAAEDFSYYSQETDACFYRLGTANTSRGITSAVHTPTFDIDEQSLRTGMGLMAYIALRKLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIU1</accession>
    <name>D7VIU1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-nucleotidase SurE</fullName>
            <ecNumber evidence="5">3.1.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nucleoside 5'-monophosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">surE</name>
        <name evidence="7" type="ORF">HMPREF0766_10910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998454.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10910"/>
    <dbReference type="EnsemblBacteria" id="EFK59993">
        <property type="protein sequence ID" value="EFK59993"/>
        <property type="gene ID" value="HMPREF0766_10910"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045192_1_0_10"/>
    <dbReference type="OrthoDB" id="1909278at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00060">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="PTHR30457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SSF64167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SurE" evidence="6">
        <location>
            <begin position="8"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="257" mass="28327" checksum="509CE2AFB6F33B2D" modified="2010-10-05" version="1">MVKKKPTILVVNDDGITAPGIKVLIEEMQKLGHVVVVAPDSPQSGMGHAITIGKPLRLDKVNLYEGVEMYKCSGTPVDCVKLAVNKIFKGKKPDICVSGINHGLNNSINVLYSGTMSAAVEGAIESIPSIGFSLDDFTYDANFDPCRPYIVSITQQVLNNGLPKNTLLNVNFPQGNDIKGIKICRQAGARWVEEFDERVDPHNRDYFWLTGKFQLEDRGEDTDAHALNHGYVSVVPTQYDMTAHHAIPELNSWSFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIV5</accession>
    <name>D7VIV5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK60007">
        <property type="protein sequence ID" value="EFK60007"/>
        <property type="gene ID" value="HMPREF0766_10924"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3317191_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK60007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="39" mass="4367" checksum="B7DA6E4D563800AD" modified="2010-10-05" version="1">MQEPLLWQPAGVAPATAVPLPQPPPDEQLPHPIFFPYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJG2</accession>
    <name>D7VJG2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monovalent cation/proton antiporter, MnhG/PhaG subunit</fullName>
            <ecNumber evidence="2">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mnhG</name>
        <name evidence="2" type="ORF">HMPREF0766_11131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.5" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000628.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11131"/>
    <dbReference type="EnsemblBacteria" id="EFK59015">
        <property type="protein sequence ID" value="EFK59015"/>
        <property type="gene ID" value="HMPREF0766_11131"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121334_0_0_10"/>
    <dbReference type="OrthoDB" id="2051355at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005133">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34703">
        <property type="entry name" value="PTHR34703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03334">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01300">
        <property type="entry name" value="CPA3_mnhG_phaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="121" mass="13142" checksum="31D573E5B2ECF25E" modified="2010-10-05" version="1">MTDIFLAIFSTIGALAILFASIGILRMPDFYLRLSVTVKAATLGVGFFLLCAAIIFPDVSVTTKAIAITFFLILTAPVAAHMIGRAAYITGAKLWKGTIIDDLEGKYDEETHQLKGEEEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJI1</accession>
    <name>D7VJI1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0766_11150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000656.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11150"/>
    <dbReference type="EnsemblBacteria" id="EFK59034">
        <property type="protein sequence ID" value="EFK59034"/>
        <property type="gene ID" value="HMPREF0766_11150"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006354_2_4_10"/>
    <dbReference type="OrthoDB" id="652304at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="10">
        <location>
            <begin position="70"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="9">
        <location>
            <begin position="427"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK59034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="747" mass="83764" checksum="CFCAB2C6D06E53A6" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJN7</accession>
    <name>D7VJN7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP synthase, delta/epsilon subunit, beta-sandwich domain protein</fullName>
            <ecNumber evidence="8">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">atpC</name>
        <name evidence="8" type="ORF">HMPREF0766_11206</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.14" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000770.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11206"/>
    <dbReference type="EnsemblBacteria" id="EFK59090">
        <property type="protein sequence ID" value="EFK59090"/>
        <property type="gene ID" value="HMPREF0766_11206"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084338_4_1_10"/>
    <dbReference type="OrthoDB" id="1696893at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 6" id="KW-0139">CF(1)</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="7">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="82" mass="8652" checksum="36A94B872D1472A6" modified="2010-10-05" version="1">MKLTIITPDKLAYEGDVTAVTVPGSAGSFQILKNHAPIVSTLEDGPVIIKAGNNEEVLNIKSGVIEVKNNVIIVLAEGIIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJR1</accession>
    <name>D7VJR1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000841.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11230"/>
    <dbReference type="EnsemblBacteria" id="EFK59114">
        <property type="protein sequence ID" value="EFK59114"/>
        <property type="gene ID" value="HMPREF0766_11230"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033XI4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1915754_0_0_10"/>
    <dbReference type="OrthoDB" id="1828088at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="133" mass="15501" checksum="0F9E5BD5203CEB9F" modified="2010-10-05" version="1">MGIRFEKDSLMNWMNEIGKYLRLITDKFTAFDEPEDPDFFDNGYSTFFGKDRAFFLNQTSESLQAYFQQELEVEQLRPLALILMNDGLHTADTEQQKNLLTKAKQVLNYVMSQTSSFAFEDYAYLSTIDSKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK18</accession>
    <name>D7VK18_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YkuD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_11337</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998843.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11337"/>
    <dbReference type="EnsemblBacteria" id="EFK58620">
        <property type="protein sequence ID" value="EFK58620"/>
        <property type="gene ID" value="HMPREF0766_11337"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_815489_0_0_10"/>
    <dbReference type="OrthoDB" id="275419at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="207"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="343" mass="39222" checksum="0B2168278A894697" modified="2010-10-05" version="1">MKQTKQVYLTFYIILLLSSCTSKKSPEQTQENNKKDSLEQVAKMQKEAERQKPVEASDINLKKDFLYDKHSLEDTYPYKDTTRNFQWDKIKERLAYVVNFQKKTGQYAILQNYKNKNREAPVVKHFERNAYTRVSDSLGVERYQSAPLYVVGETDKPIRYGRDGSLVRLLSSDTLDMVKIEGISFDGTWDVPKRYVKAISDSTTFNHVVVVDVRNQNICTLEGSGKDWTIRSMNPATSGRHKPPHAQETPVGLFMIQEHKSKMFYYKDGTTTIDGFAPYASRFTNGAYIHGIPVNKPATAIIEYSSSLGTVPRSHMCVRNASSHAKFIYNWAKPMNALVIVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK21</accession>
    <name>D7VK21_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998852.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11340"/>
    <dbReference type="EnsemblBacteria" id="EFK58623">
        <property type="protein sequence ID" value="EFK58623"/>
        <property type="gene ID" value="HMPREF0766_11340"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033401_5_3_10"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="191" mass="22134" checksum="62E22E9F98974F04" modified="2010-10-05" version="1">MSEQYTQDETFERMDYTSLALAKGEYDNCTFINCNFAEQDLSGFKFIDCSFKHCNLSLVRLEKTALRDIIFEDSKMIGIRYENCLDFGLAFSFTRCQLHHSSFYGLSLKKIVFKECSLQEIDFSESDLSQAVFENCDLLRANFYHTNLEKADFRSACNYSIDPENNKLKKARFSVSGIAGLLDKYNLQIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKI2</accession>
    <name>D7VKI2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Linear amide C-N hydrolase, choloylglycine hydrolase family protein</fullName>
            <ecNumber evidence="4">3.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">secA2</name>
        <name evidence="4" type="ORF">HMPREF0766_11501</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C59 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.-" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999289.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK58784">
        <property type="protein sequence ID" value="EFK58784"/>
        <property type="gene ID" value="HMPREF0766_11501"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045206_0_1_10"/>
    <dbReference type="OrthoDB" id="636485at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029132">
        <property type="entry name" value="CBAH/NAAA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02275">
        <property type="entry name" value="CBAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBAH" evidence="3">
        <location>
            <begin position="34"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="360" mass="39866" checksum="20FE681C16484F0F" modified="2010-10-05" version="1">MENKKISTFGRQFQLACIGLACGLSLLPSSLDACTRLVYKGPSNTVITARSMDWKDDIPANLWIFPRGMKRNGEIGQYSLEWTSRYGSLITSAFDIATTDGMNEKGLVANVLWLVESKYEAFNPKDGKKGLAISAWAQYMLDNFATVQEVVDAMRKHEFVVVSDVIPGTDKFTALHLSVSDAGGDNAIFEYIDGKLVIHHDPSYTVMTNSPVFDQQLALSNYWSSIPGNIMLPGTNRAADRFARAKFYLGAIPQTDDTRVAVGSVMSVIRNCSVPFGISSEQEPNISSTRWRSLSDHKNLVYYFETVLTPNTFWVDMKKVDFSEKGKVLKLSVAHNETYSGESSGSFKVTAPFKFAGATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKI8</accession>
    <name>D7VKI8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999309.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11507"/>
    <dbReference type="EnsemblBacteria" id="EFK58790">
        <property type="protein sequence ID" value="EFK58790"/>
        <property type="gene ID" value="HMPREF0766_11507"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133235_0_0_10"/>
    <dbReference type="OrthoDB" id="1278667at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037079">
        <property type="entry name" value="AF2212/PG0164-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015018">
        <property type="entry name" value="DUF1905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08922">
        <property type="entry name" value="DUF1905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="166" mass="19313" checksum="86A9FAAD901472A8" modified="2010-10-05" version="1">MTKNQQTSKRGSDLLVDKVYTIEKFEGKGGWYYVRLPEIAQDRNAKFGWVSVRGTIDHYEIRNYNLQAMGNGILFLPVKADIRKKINKKDGDQVHIRLFRDSSGLEIPEELKDCLMDEPDLYKCFMDLPEKERKSIITRICSAKKEAEKIDRIAKTLQDLSRIQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKN1</accession>
    <name>D7VKN1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arylsulfatase</fullName>
            <ecNumber evidence="8">3.1.6.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_11550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.-" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999398.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11550"/>
    <dbReference type="EnsemblBacteria" id="EFK58833">
        <property type="protein sequence ID" value="EFK58833"/>
        <property type="gene ID" value="HMPREF0766_11550"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014653_3_1_10"/>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012160">
        <property type="entry name" value="LtaS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005091">
        <property type="entry name" value="Mmb_sulf_HI1246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="7">
        <location>
            <begin position="272"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="626" mass="72530" checksum="C2569CA3C5E7489F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL97</accession>
    <name>D7VL97_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999910.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK58370">
        <property type="protein sequence ID" value="EFK58370"/>
        <property type="gene ID" value="HMPREF0766_11766"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_34_1_10"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="81" mass="9370" checksum="1456AEFD417699BA" modified="2010-10-05" version="1">MKGKTNITPFEQSVIDFVVKLRNRKNLTQQDIATILHVERTFITSVESKNSRAKYNLNHLNMIADHFGMSPKDFLPEKPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLE6</accession>
    <name>D7VLE6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PKD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000054.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11816"/>
    <dbReference type="EnsemblBacteria" id="EFK58419">
        <property type="protein sequence ID" value="EFK58419"/>
        <property type="gene ID" value="HMPREF0766_11816"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037206_0_0_10"/>
    <dbReference type="OrthoDB" id="1025055at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="122"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="544" mass="59119" checksum="387FEDBE2E9DA9CD" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLM4</accession>
    <name>D7VLM4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipid kinase, YegS/Rv2252/BmrU family</fullName>
            <ecNumber evidence="2">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000234.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11894"/>
    <dbReference type="EnsemblBacteria" id="EFK58497">
        <property type="protein sequence ID" value="EFK58497"/>
        <property type="gene ID" value="HMPREF0766_11894"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045532_1_2_10"/>
    <dbReference type="OrthoDB" id="869726at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005218">
        <property type="entry name" value="Diacylglycerol/lipid_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00147">
        <property type="entry name" value="TIGR00147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="292" mass="32134" checksum="CE713CE4AA679C15" modified="2010-10-05" version="1">MAERKRILFVVNPISGGKRKTAFNKQVLEVLDLQKFNPTFQQTNHPNHAYELGKLAIEEKYDAVVAVGGDGTINELGSALVGSDIPLGIIPEGSGNGLALYLGIPMNEAAALRRLNRFEAVEVDSGLINDRNFFNIAGIGFDASVSDRFANENIRGPIGYLKSAINVLSNYKPCTYKLTIDGVQYEREAFMISVANSPQYGNNAYIAPQASVNDGVLDVCIVHKFPLYTLPMMVFHLFNKSADQSEYVEIIPGKEITIEREKDGAAHVDGEPFELGKKLDIRILPKSLRIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLP0</accession>
    <name>D7VLP0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000276.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11910"/>
    <dbReference type="EnsemblBacteria" id="EFK58513">
        <property type="protein sequence ID" value="EFK58513"/>
        <property type="gene ID" value="HMPREF0766_11910"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008305_0_0_10"/>
    <dbReference type="OrthoDB" id="946896at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018580">
        <property type="entry name" value="Uncharacterised_YfhO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38454">
        <property type="entry name" value="PTHR38454"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09586">
        <property type="entry name" value="YfhO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="791"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="829" mass="93138" checksum="24A46056F33A1FFD" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLV3</accession>
    <name>D7VLV3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK57958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11950"/>
    <dbReference type="EnsemblBacteria" id="EFK57958">
        <property type="protein sequence ID" value="EFK57958"/>
        <property type="gene ID" value="HMPREF0766_11950"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_620466_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025667">
        <property type="entry name" value="SprB_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13573">
        <property type="entry name" value="SprB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="442" mass="45214" checksum="7836E49AF5823037" modified="2010-10-05" version="1" fragment="single">MKSSNYYNNILKSIKGMRMGVLLFLLSYILFIGKAWGQTEITETFESAAAGASTFTSGGKTFTIISKAESGQFDIQDLYPGTGWNGTGPDNKYIDNDGTAEAFIDQSFSIKIEAGLTYSVKKFYLFLADHNVEQYTSGTVTIKGKLGGTTVFTATATSGFVQSTATNNGFTPIDLTTFGGANNSTKVIDELEISTTEPFTYVCLDALTWKLEYVCPTITIDTQAQTNVACKGTATGSVTVAPSGGTAPYSYSWTLGAGTAATASNLTAGTYTVTVTDKMGCTATKTITITEPAAALAGTATKTDVSCFGGNNGTATVAVTGGTSGYSYSWAPSGGTAATASGLAAGTYTVTVKDANNCQITRTVTVGQPAAALAGTATKTDVSCFGGGNGRATVSVTGGTPGYTYSWAPSGGTAATATGLSAGTYTVTVTDANACQITRTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLY2</accession>
    <name>D7VLY2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter, CPA2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nhaP</name>
        <name evidence="8" type="ORF">HMPREF0766_11979</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK57987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001101.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11979"/>
    <dbReference type="EnsemblBacteria" id="EFK57987">
        <property type="protein sequence ID" value="EFK57987"/>
        <property type="gene ID" value="HMPREF0766_11979"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_8_1_10"/>
    <dbReference type="OrthoDB" id="1194802at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="9"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK57987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="420" mass="45556" checksum="BC6A5644B7F68D34" modified="2010-10-05" version="1">MELYYTFSILIVLAAIFAYLNHRFLRLPSSIGIMLIALLVSVCIVLFGDRIAGNEISKFSSMITKLDFSDVLMGAMLNFLLFAGAIHININDLKSQKGAVMFFSTLGVVISTFMVGLLMYYILPVLNIHLPLIYCLIFGALISPTDPIAVLSILKTTGVSKALETKFAGESLFNDGVAVVLFAVLLNIALGTSTDITIANVGWLFVKEAGGGLVLGIALGQLCSYLMRKIDDYKVSVLMSLAVVMGGYLVAHSFHCSGPLTMVAAGLIIGNKNNTKGAMSEETKDYLNKFWELIDEILNAILFLIIGFELLIIPSIPNYWILGFTSVVLVLIARFVSIYIPGRLFPKLNINKAATTLLVWGGLRGGVSIALALSLPVGEHKDLVLGITYFVVIFSILVQGLTLGNLAGRIKKMATQDKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM19</accession>
    <name>D7VM19_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001212.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK58024">
        <property type="protein sequence ID" value="EFK58024"/>
        <property type="gene ID" value="HMPREF0766_12016"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032RPG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1433058_0_0_10"/>
    <dbReference type="OrthoDB" id="1732913at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107302" evidence="1">
        <location>
            <begin position="19"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="192" mass="21585" checksum="9EF95F16AC75209C" modified="2010-10-05" version="1">MKPFISLLFCLVMLSAIAQTGTYRRTDKTGASCTIAVQKSQSQLKGQIFAWWNTSSGTHGAFSGQGMIRDSICTLRTQEESTCCVRLSFSNNALNAIFSDCNTENLPEDFAGNYIKITTQIPGEYLIKTAKAYFYKTTKSNSHLRTYLLKGDKVQTDLENIIDNKWVFVNYTNTSGKTSTGYMLWQNFNIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM61</accession>
    <name>D7VM61_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001333.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12058"/>
    <dbReference type="EnsemblBacteria" id="EFK58066">
        <property type="protein sequence ID" value="EFK58066"/>
        <property type="gene ID" value="HMPREF0766_12058"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1348213_0_0_10"/>
    <dbReference type="OrthoDB" id="1650079at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="203" mass="23332" checksum="97BCDD95344449F6" modified="2010-10-05" version="1">MTSVFNKLWNRTATGNSGASAIENQLSFLECQVDRKLLDLWASACIENKDQSWQIRFAKLQQSSLSRVCSQPVSVIDEIDCLNEYCLVYQHIKSEELYINFKSDYTDTAALIYPFVLMPLVQNAIHNGYTSMEKYPVKIKVSGSARLLIMEVSNRVNHRIADQQGTDSIRLFRERLQFLYPDRNDLLFNSNSNTFKATLTVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM71</accession>
    <name>D7VM71_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">alr</name>
        <name evidence="7" type="ORF">HMPREF0766_12068</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001353.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12068"/>
    <dbReference type="EnsemblBacteria" id="EFK58076">
        <property type="protein sequence ID" value="EFK58076"/>
        <property type="gene ID" value="HMPREF0766_12068"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0787">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_372082_0_0_10"/>
    <dbReference type="OrthoDB" id="859043at2"/>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="6">
        <location>
            <begin position="690"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="711"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="584"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="760"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="813" mass="91720" checksum="E1F2B7F79DF6853F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMN8</accession>
    <name>D7VMN8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, BlaI/MecI/CopY family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992713.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12258"/>
    <dbReference type="EnsemblBacteria" id="EFK57185">
        <property type="protein sequence ID" value="EFK57185"/>
        <property type="gene ID" value="HMPREF0766_12258"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119090_4_0_10"/>
    <dbReference type="OrthoDB" id="2027769at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="123" mass="14377" checksum="5E1929FCD3ABBB77" modified="2010-10-05" version="1">MDEIKELTKAEEQIMHEVWEINGGFVKDVIERLPEPKPAYNTVSTIVRILETKGFLMHKSYGKSHQYLPKISKEEYKKVITGKLLNNYFDNSAKSMLSFFLEEDKLNLKDVNELLEIIAKQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMR7</accession>
    <name>D7VMR7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="7">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="7">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">fabH</name>
        <name evidence="10" type="ORF">HMPREF0766_12287</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992758.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12287"/>
    <dbReference type="EnsemblBacteria" id="EFK57214">
        <property type="protein sequence ID" value="EFK57214"/>
        <property type="gene ID" value="HMPREF0766_12287"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039592_3_1_10"/>
    <dbReference type="OrthoDB" id="872193at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="9">
        <location>
            <begin position="110"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="8">
        <location>
            <begin position="240"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="7">
        <location>
            <begin position="257"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK57214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="329" mass="35766" checksum="8D5E933BC29B96DF" modified="2010-10-05" version="1">MSKIHAAITAVNGYVPDYVLTNKELETMVDTNDEWIVSRTGIKERRILKGEGKATSDLAVPAVLGLLKKRGITAEEIDLIVFCTSTPDMLFPATANILADKIGAKNAWGFDLQAACSGFLFGLNTASQFIISGTHKKVLVVGADKMSSVVNYKDRNTCILFGDGCGAVLLEPNEEGMGIQDAILKTDGSGGQYLNIKGGGSLNPATHETVDAEMHYAYQEGRTVFKFAVTNMADVAAEIMDKNNLTSADINWLVPHQANKRIIDATAERVGLPEEKVMVNIQKYGNTTSATIPMCLWEWENQLKKGDNLILAAFGGGFTWGSIYLKWAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMS8</accession>
    <name>D7VMS8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">secE</name>
        <name evidence="8" type="ORF">HMPREF0766_12298</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992776.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12298"/>
    <dbReference type="EnsemblBacteria" id="EFK57225">
        <property type="protein sequence ID" value="EFK57225"/>
        <property type="gene ID" value="HMPREF0766_12298"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113663_6_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK57225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="64" mass="7150" checksum="47E91735FEBB9B52" modified="2010-10-05" version="1">MAKVLDFFKDSYEEITQKVTWPTWAQLQSSAVIVLIASLIIALLVFVMDKASSNVLELLYGITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMU7</accession>
    <name>D7VMU7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="7">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">tyrS</name>
        <name evidence="9" type="ORF">HMPREF0766_12317</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992810.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12317"/>
    <dbReference type="EnsemblBacteria" id="EFK57244">
        <property type="protein sequence ID" value="EFK57244"/>
        <property type="gene ID" value="HMPREF0766_12317"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024003_0_3_10"/>
    <dbReference type="OrthoDB" id="402899at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="229"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK57244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="427" mass="48293" checksum="2B21ABF8E5E3B264" modified="2010-10-05" version="1">MNFVEELRWRGMLQDIMPGTEELLNKEKVSGYIGFDPTGDSLHVGHLTQIMTLIHFQNAGHKPVALVGGATGMIGDPSFKSAERNLLDEETLNHNVASLKHQLSKFLTFGEGELDAKMVNNYDWFKDFKFLDFIRDIGKLITVNYMMAKDSVKKRLEGENGLSFTEFSYQLIQGYDFYYLWKHHNCKIQMGGSDQWGNIVTGTEFIRRQDQGSAFALTTQLIKKSDGQKFGKTESGAVWLDAKKTTPYKYYQFWLNATDDDAKNWIRIFTLKPKEEIEAIIAEHDAAPHTRTVQKALAKDITIRTHSEKDYETALKTSEFLFGNGSLDFLGDLEHNAVLDVFDGVPQFKISKSELAEGINILDLLATKTQIFPSKGEARKMTEGGGVSVNKEKVSGTDATFTTENLINNKYIIAQRGKKNYYLIIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN34</accession>
    <name>D7VN34_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helicase C-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992934.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12404"/>
    <dbReference type="EnsemblBacteria" id="EFK57331">
        <property type="protein sequence ID" value="EFK57331"/>
        <property type="gene ID" value="HMPREF0766_12404"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014765_3_1_10"/>
    <dbReference type="OrthoDB" id="377818at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="20"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="499" mass="55784" checksum="6B77162ADD611AB2" modified="2010-10-05" version="1">MKVMLPTLRPYQAEFVKNLAVALRDHRRVIACAPTGSGKTKMFIDIAYKSISNGRAVVIISETTKIFDQIIGEAGGIEIANGKKHVHIKAGQLYIAMAQTLTRRPLILEQLAQLEFPPLIIVDEAHIGTPSNIIRRLIEVSNPYILGFTATPDGRVAKHLTELYNTCVVCCQVDELIQQGFLCSYQHLARTKADTDILEMRNGEYTEQSQTAAFSTAAVYDGIFEDLRSATFKKCMIFVSSIKHAREMNERLLAGGFECVEYHSQLENGSYELAKFTELGLANICVSVASLTKGFDAPAVDLVILNRATTSLPLYLQMIGRGSRPVWAPDGMPLKAHFRVLDYGGNWERHGLYFEDRDWENMWEVTKRSKKGEGVAPVALCPSCESIISTTQRICPFCGHERPLTEKELEQGELVEVTSHYTSLIGRKISELTPIELAIYAKMKKKQVFATRVAKAKEQMHKGFLSAFGAAMGYKSTWVDIQSRMIGSMPIEFTDIQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN62</accession>
    <name>D7VN62_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992975.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12432"/>
    <dbReference type="EnsemblBacteria" id="EFK57359">
        <property type="protein sequence ID" value="EFK57359"/>
        <property type="gene ID" value="HMPREF0766_12432"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1488154_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="181" mass="19063" checksum="B4E994AB74F62E8A" modified="2010-10-05" version="1">MAQFVVKGVESIEFAPVSTDGTLPATGWVKGENIEMGSATMNIPEKTMTKVKVEDKAGIFAIIGEEGDGASVTAKFLNLDPKMADLIFKGNATSTATTKFEAAIDSTTAVNLAVRVTSKPWDGFKMVFVILNGSVIGRIENALTKDGDAFLALGFTAEAQAVSDADGDAVSPWYYEKVAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN95</accession>
    <name>D7VN95_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter, major facilitator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hsrA</name>
        <name evidence="7" type="ORF">HMPREF0766_12465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993014.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12465"/>
    <dbReference type="EnsemblBacteria" id="EFK57392">
        <property type="protein sequence ID" value="EFK57392"/>
        <property type="gene ID" value="HMPREF0766_12465"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="10"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="461" mass="51004" checksum="EE451A9D766FD8CD" modified="2010-10-05" version="1">MNTDSVKKFLPLILATAIFMQMLDSTILNTSLPAIARDLNESPLDMQNAIVSYVLTLALFMPVSGFLADKFGTKHVFIASLFLFSLGSLFCSLSQNLNELVIARVFQGVGGSLMTPVGKLALIKTFDKKELLKAINYAIVPALIGPVLGPLVGGYLVDYLSWHWIFLINIPIGVLGIILGLKYMPNYKSPITDFDLKGFLIFAMASLLLSISLELFGNANNITPVLLGFLLGFLMLFFYYKHARKDNNPIFPLNLFQVRTFRVGILGNLATRLGISSIPLLVPLMIQIAYDRSAFTSGWIVAPMALTSIFGKSVVIKILDKFGYRSTLMVNTFIIGILICSLAIPGIHNSIYWYVPILLLLGFFNSIQFTSMNTITIADLRTFQTSSGNSLVSVNQQFAVGFGIAFGLIILKIFEGDTKFIHNQIHNAFRYTFLIVGVLTILSGLVFRRLNFRDGDNLKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNI6</accession>
    <name>D7VNI6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rplS</name>
        <name evidence="7" type="ORF">HMPREF0766_12556</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993135.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12556"/>
    <dbReference type="EnsemblBacteria" id="EFK57483">
        <property type="protein sequence ID" value="EFK57483"/>
        <property type="gene ID" value="HMPREF0766_12556"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103507_2_2_10"/>
    <dbReference type="OrthoDB" id="1698718at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="115" mass="13052" checksum="6A937D4B06FF4DBB" modified="2010-10-05" version="1">MDLVKFVEEQAVTKNEIPAFKAGDTISVHYKIREGNKERVQVYQGVVIQLNSEGTNATFTVRKISNGIGVERIFPVNSPNIDQIVVNSYGKVRRAKLFYLRDRTGKAARIKTRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNR3</accession>
    <name>D7VNR3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993241.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12633"/>
    <dbReference type="EnsemblBacteria" id="EFK57560">
        <property type="protein sequence ID" value="EFK57560"/>
        <property type="gene ID" value="HMPREF0766_12633"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2582302_0_0_10"/>
    <dbReference type="OrthoDB" id="1838027at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="89" mass="10498" checksum="B87F8794087D77AB" modified="2010-10-05" version="1">MVKRKQNVTATIYTKAISNQLQLDIKRYNSQYLPIEIKVFSDTHDRFLIIDQAELYHIGASLKDLGKKWFAFSRMDIEVGRMLHILNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNY6</accession>
    <name>D7VNY6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993360.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12706"/>
    <dbReference type="EnsemblBacteria" id="EFK57633">
        <property type="protein sequence ID" value="EFK57633"/>
        <property type="gene ID" value="HMPREF0766_12706"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZBU9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1641884_0_0_10"/>
    <dbReference type="OrthoDB" id="1472055at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045534">
        <property type="entry name" value="DUF6428"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20001">
        <property type="entry name" value="DUF6428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="154" mass="17145" checksum="72923515DCCABE78" modified="2010-10-05" version="1">MKLSNIKEILPSLNNVEFQLEDGTFVPEHFHVTEVGQIIKNFIDCGGVQRNEKTVSFQLWNADDYEHRLKPGKLLHIIQLSEEKLGIEDAEIEVEYQAGTIGKYDLDFNGKTFVLRNKTTSCLAQDACGIPDSKPKIALSQLNNSGCSPDSGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNY7</accession>
    <name>D7VNY7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993363.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12707"/>
    <dbReference type="EnsemblBacteria" id="EFK57634">
        <property type="protein sequence ID" value="EFK57634"/>
        <property type="gene ID" value="HMPREF0766_12707"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_3_2_10"/>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="109" mass="12408" checksum="DE22AE6BEB5E1692" modified="2010-10-05" version="1">MGITKTEIFTDEQNKLASLFKVLGHPARIAILQYIIDQKTCICNDLVDELGLAQATISQHLKELKNMGIIKGSIEGKSVCYCIEEKVWKHFQQQFNIFFNQDVAVKQCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP17</accession>
    <name>D7VP17_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acylglucosamine 2-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acylglucosamine 2-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.8" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993422.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12737"/>
    <dbReference type="EnsemblBacteria" id="EFK57664">
        <property type="protein sequence ID" value="EFK57664"/>
        <property type="gene ID" value="HMPREF0766_12737"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046651_0_1_10"/>
    <dbReference type="OrthoDB" id="783590at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050121">
        <property type="term" value="F:N-acylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00249">
        <property type="entry name" value="AGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034116">
        <property type="entry name" value="AGE_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="382" mass="45136" checksum="B1A7856B48DE2AD1" modified="2010-10-05" version="1">MKIYSDIYKNELLEQVIPFWEKYSIDRECGGYFTCLDRQGNVFDQDKFMWLQGRQVWMFSFLYQHCEQKQEWLDIALHGAAFMEQYGRDAEGNWYFSLNREGKPLVQPYNIFSDCFATMGFSALYKATGNTTYSAIAKQTFEQILKRRTDTKGVYNKIYPGTRDLRNFSLPMILSNLALEMEELLDKQVVEQLLDEIIHEVMEVFYNEERGIIFENVNPDGSFSNSFEGRLLNPGHTLEAMWFIMDLAVRKGDRSLIDKALEIALKALEYGWDKEYEGIFYFLDSEGHPPQQLEWDQKLWWVHLEALVCMAKAWKLTGDERAKAWFVKLHDYSWEKFRDAEYGEWYGYLNRRGEVLLPLKGGKWKGCFHAPRALWQIHQTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPD4</accession>
    <name>D7VPD4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ferredoxin--NADP reductase</fullName>
            <shortName evidence="2">FNR</shortName>
            <shortName evidence="2">Fd-NADP(+) reductase</shortName>
            <ecNumber evidence="2">1.18.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12854</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:20125"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferredoxin--NADP reductase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993623.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12854"/>
    <dbReference type="EnsemblBacteria" id="EFK57781">
        <property type="protein sequence ID" value="EFK57781"/>
        <property type="gene ID" value="HMPREF0766_12854"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_5_10"/>
    <dbReference type="OrthoDB" id="692968at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01685">
        <property type="entry name" value="FENR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022890">
        <property type="entry name" value="Fd--NADP_Rdtase_type_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="1 2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="5"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="334" mass="36824" checksum="9201DDF4CE622BF5" modified="2010-10-05" version="1">MITTDICIIGAGPVGLFAVFEAGLLKMRCHLIDVLPQVGGQLSEIYPHKPIYDIPGYPAINAQELINNQMEQIAPFHPTFTLGERVEGLNKQEDGSYHVIGSEGTVIHCQVVVIAGGLGCFEPRKPEIQNLDTFEHNSVHYMVRDPERFRDKNILIAGGGDSALDWTIFLADVAKSITLVHRSDSFRGAPDSAEKVYKLANEGKIDLLLSHNLVALQGNGTLQEVHLQNKQKEAVVVNTEHFIPLYGLSPKLGPIADWGLSIDKNAIVVDTFDYSTNVERIFAIGDINTYPGKLKLILCGYHEAALMAQSAFKYVYPDQKLSFKYTTVNGVNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPH8</accession>
    <name>D7VPH8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">dxr</name>
        <name evidence="11" type="ORF">HMPREF0766_12898</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993721.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12898"/>
    <dbReference type="EnsemblBacteria" id="EFK57825">
        <property type="protein sequence ID" value="EFK57825"/>
        <property type="gene ID" value="HMPREF0766_12898"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0743">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035714_4_0_10"/>
    <dbReference type="OrthoDB" id="1200722at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="8">
        <location>
            <begin position="6"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="9">
        <location>
            <begin position="146"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DXPR_C" evidence="10">
        <location>
            <begin position="261"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK57825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="383" mass="42085" checksum="C5CDA90F69901029" modified="2010-10-05" version="1">MEYKTIAVLGSTGSVGTQALDVVESFPERLKVSVLTAGSNADLLIKQALQFQPRAVVIVDDSQYLCVKEALAGHPIAVSSGEAALEEVVQYEDIDIVLNAIVGSAGLRSTVRAIQSGKDIALANKETLVVAGELVMGLARKHQVRMLPVDSEHSAIFQCLTGEEANPIEKIYLTASGGPFRGKDLDFLSSVTKQQALKHPNWSMGAKITIDSASLMNKGLEVIEAKWLFDLDVSQVDVIVHPQSIIHSLVQFRDGSMKAQMGLPDMKLPIQYALTYPYRWENTFERFDFANFASLTFEPADTKTFRNLAIAYEALRQGGNSACVMNAANEIVVDAFLKEKVSFLGMSEVIEKTLERVQHVATPTLEDYLYADQESRRIAQELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPI8</accession>
    <name>D7VPI8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HSDR_N_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993745.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12908"/>
    <dbReference type="EnsemblBacteria" id="EFK57835">
        <property type="protein sequence ID" value="EFK57835"/>
        <property type="gene ID" value="HMPREF0766_12908"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115841_1_0_10"/>
    <dbReference type="OrthoDB" id="1452055at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029464">
        <property type="entry name" value="HSDR_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13588">
        <property type="entry name" value="HSDR_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSDR_N_2" evidence="1">
        <location>
            <begin position="38"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="152" mass="18015" checksum="8DC344F236D0942E" modified="2010-10-05" version="1">MFTPIPLNLPPFSAKLSRENDIIFIYDELRKKKLVLTPEEWVRQHWINYLHQEKKYPKSLMKTEGGLRLNTLQKRSDLLVYNNKGEKILLAEFKAPHVKITQSVFEQIANYNTVHQIPLLLVSNGLDHFYCKISFETKSYEFLKDLPDYFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPL1</accession>
    <name>D7VPL1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA repair protein RadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">radC</name>
        <name evidence="8" type="ORF">HMPREF0766_12931</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPF0758 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993786.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12931"/>
    <dbReference type="EnsemblBacteria" id="EFK57858">
        <property type="protein sequence ID" value="EFK57858"/>
        <property type="gene ID" value="HMPREF0766_12931"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073529_0_2_10"/>
    <dbReference type="OrthoDB" id="1833204at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020891">
        <property type="entry name" value="UPF0758_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00608">
        <property type="entry name" value="radc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01302">
        <property type="entry name" value="UPF0758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="106"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK57858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="229" mass="26005" checksum="CC68ED3A5695F24E" modified="2010-10-05" version="1">MGKLAINKWAENDRPREKLERRGRRVLSNAELLAILIGSGSFGEDAVGLARRILSDHQHNLDFLSQQDVDDLKKYKGIGSAKAITIIAALELGRRRKESTEKEAIILNCSKKVFEYFKFQLQDLLHEEFWVLYLNRASVILNQQLIGKGGNDFTPVDVRIILKHALNCQASSMILVHNHPSGSLKPSNQDLQLTKKIVDASKIMDIRVMDHVIFTNSKYFSFQDEGLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPL6</accession>
    <name>D7VPL6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_12936</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993791.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12936"/>
    <dbReference type="EnsemblBacteria" id="EFK57863">
        <property type="protein sequence ID" value="EFK57863"/>
        <property type="gene ID" value="HMPREF0766_12936"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_2_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107209" evidence="5">
        <location>
            <begin position="23"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="116"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="428"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK57863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1005" mass="110757" checksum="7AC784BA00D9734D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPT8</accession>
    <name>D7VPT8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13008"/>
    <dbReference type="EnsemblBacteria" id="EFK57935">
        <property type="protein sequence ID" value="EFK57935"/>
        <property type="gene ID" value="HMPREF0766_13008"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2934081_0_0_10"/>
    <dbReference type="OrthoDB" id="2074723at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="63" mass="7239" checksum="713836F9E2706E3E" modified="2010-10-05" version="1">MKNKIGFNLVFALIAFPIGLALLREFDFQTFTFKKTALGILYLITFIACVFFMLRKNKIDGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPV5</accession>
    <name>D7VPV5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nahA</name>
        <name evidence="7" type="ORF">HMPREF0766_13025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993918.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13025"/>
    <dbReference type="EnsemblBacteria" id="EFK57952">
        <property type="protein sequence ID" value="EFK57952"/>
        <property type="gene ID" value="HMPREF0766_13025"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007082_5_0_10"/>
    <dbReference type="OrthoDB" id="727559at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107498" description="Beta-N-acetylhexosaminidase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="6">
        <location>
            <begin position="623"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="761" mass="86298" checksum="67024C8EA5F43373" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ06</accession>
    <name>D7VQ06_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter, CPA2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">napA</name>
        <name evidence="6" type="ORF">HMPREF0766_13060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993977.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13060"/>
    <dbReference type="EnsemblBacteria" id="EFK55857">
        <property type="protein sequence ID" value="EFK55857"/>
        <property type="gene ID" value="HMPREF0766_13060"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_10_2_10"/>
    <dbReference type="OrthoDB" id="941006at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="69"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK55857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="758" mass="84359" checksum="32C3CA1C54E7FEA5" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ07</accession>
    <name>D7VQ07_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK55858">
        <property type="protein sequence ID" value="EFK55858"/>
        <property type="gene ID" value="HMPREF0766_13061"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3030114_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="55" mass="6417" checksum="1A9E0E0291B60021" modified="2010-10-05" version="1">MLPLKKSENIIGASVNIYFSYIQKMLLYFMENLSPSKPQALLKKESETDEVCLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ89</accession>
    <name>D7VQ89_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13143"/>
    <dbReference type="EnsemblBacteria" id="EFK55940">
        <property type="protein sequence ID" value="EFK55940"/>
        <property type="gene ID" value="HMPREF0766_13143"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_2_10"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="244"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="347" mass="40422" checksum="1281ACB5477A35C5" modified="2010-10-05" version="1">MIHSRLLKAIKLLLIDGNVIFVCYLTDADMEVIQKNKKSEGKNFATVPQSKNNSLDVCEVCGSVRHVVFQNFLSIVPLEMIKSCQRDTPFHSTRKGFYSMILITKGRATETIAYQTYTFEGGTLYFIPENTLHKIQHWSEDIEGYHCSFDSEYFLLCLKNQIKLMEYPFFIPDNDPFVCLKENEMAQLVPLFDKLKHEYTNRQNYNDDLLTRLYLNALLLEVGRMYIQQSAETITHSRQEQLVSKFKRLVHAHFLTYRQVSDYADLLFVHPHYLNDMVRAITGQSASNFIYQHLLAEAKSHLVQSDDTIAQIAARLRFSDQSYFGRFFRKHAGMTPAQFRQQHTQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ98</accession>
    <name>D7VQ98_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-70 region 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13152</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994119.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13152"/>
    <dbReference type="EnsemblBacteria" id="EFK55949">
        <property type="protein sequence ID" value="EFK55949"/>
        <property type="gene ID" value="HMPREF0766_13152"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_2_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="36"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="135"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK55949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="202" mass="23845" checksum="D9F7518F30AF5081" modified="2010-10-05" version="1">MKLLRKYTDQKEPMSLRKALDDCGMGRGERGKAYVYKKYYGYLMAIVIRYIKHEMESEEVVNECFVKAFSKLDSFNLDVEEERLEKSFRSWIARIAVNQSIDFLRSKKQMLMLDDVSEYELVPHAVHNHSSLEVQDILKLLDELPDIQRTIFNMYEVEGFSHDEIASLLNIPDSTSRTYLTRAKQKLRKLYVEQFNTADHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQN0</accession>
    <name>D7VQN0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, aldo/keto reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994394.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13284"/>
    <dbReference type="EnsemblBacteria" id="EFK56081">
        <property type="protein sequence ID" value="EFK56081"/>
        <property type="gene ID" value="HMPREF0766_13284"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_10"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="333" mass="37099" checksum="E961D45C226B6773" modified="2010-10-05" version="1">MKYRKLGKSNEDVSAIGLGCMGMSFAYGTSDDQQSIETLHKALDLGINFWDTADMYGNGTNEELLSKVLVPNRDKVFIATKFGFRFRDGIARASNANETYFDGSPEWIRVAVENSLKRLKVDVIDLYYAHRVDPNIPVEETVGAMSELVKQGKVRYLGLSEASPESLKKANAVHPIMALQSEYSLLTRDVEPEILPLLKEMDIVLVPYSPLARGLVTNTLDVNQLEDQDFRKFLPRYQGENLENNTNLAATFASFARDKGVSPAQLALAWVLAQGEQIIPIPGTRRTERLVENAAAVDVSLSHAELQEIEKILAQYPNVGARYNEGSMKLVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQW4</accession>
    <name>D7VQW4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinase, PfkB family</fullName>
            <ecNumber evidence="4">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13368</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994505.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13368"/>
    <dbReference type="EnsemblBacteria" id="EFK56165">
        <property type="protein sequence ID" value="EFK56165"/>
        <property type="gene ID" value="HMPREF0766_13368"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_6_3_10"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="23"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="307" mass="34613" checksum="321BE574F8DE24F1" modified="2010-10-05" version="1">MMDNKIRIACFGEVLWDIFPGGQRRIGGAPFNVAYHLFKMGVDASMISSIGEDNLGTEIIEQLNNWNMRTDGIQVSHIHPTSTVIASLDENNEAHYDIVQNVAWDFISTRASDKHLLAQTDAFVFGTLAARQEQSRNTLFELLEASNYNVFDINLRPPYYDVRLIKELLHKTQLAKFNKAELRMMLDFLGKTYEDEKDSISYLQDTFGMNEIIVSKGSKGALYACKGDFYLYPTVTVEVKDTVGSGDSFLAGFLSKRLEQGTSPHEIMHQAVSLGAFITSHEGACPEYSLERYQQFRDSHQVTAIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR05</accession>
    <name>D7VR05_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994560.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13409"/>
    <dbReference type="EnsemblBacteria" id="EFK56206">
        <property type="protein sequence ID" value="EFK56206"/>
        <property type="gene ID" value="HMPREF0766_13409"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032Y7Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066214_1_1_10"/>
    <dbReference type="OrthoDB" id="1509557at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005901">
        <property type="entry name" value="GLPGLI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09697">
        <property type="entry name" value="Porph_ging"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01200">
        <property type="entry name" value="GLPGLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005672187" evidence="2">
        <location>
            <begin position="27"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="281" mass="32094" checksum="7D83E5F40ECC1A25" modified="2010-10-05" version="1">MKTNLITQSICLSFLFFIAFTTKASAQEYMDAYIRYAVTHIADSTRKDSPVKQDMYVYVSPNYSYYSKMKPEAFAPNQMTFSYDNIPSDAVDSYLYNKALQQYFKMEFVGNLFRVQANKKTIDWDIKDEEKEIGGYQCIKAIGTFGGRTYEAWYTPELPYAYGPWKLDGLPGLILEARDLNSDIIFAYSGFNKMSEKFDFAKLLELDETSPEKIAKAKKAMEADMLASVLASVPAGSNVTFKGEDGKEISKEEAEMLIQQHKKKQAKEKSFELNNPVEINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRD1</accession>
    <name>D7VRD1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994720.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13535"/>
    <dbReference type="EnsemblBacteria" id="EFK56332">
        <property type="protein sequence ID" value="EFK56332"/>
        <property type="gene ID" value="HMPREF0766_13535"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032W6T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_700016_0_0_10"/>
    <dbReference type="OrthoDB" id="1881726at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="394" mass="45305" checksum="EF7EBBA5477FE619" modified="2010-10-05" version="1">MKPSIYYIKLMIFILLNTSLLLSCSRQDIKPPDNPEERGILLELDSTKFPVVKKDTVVKSVYDILYQLDGLQFYIKAYDNLVLQSYGKGKNLLLEPIAPDDDSQLFYFKFSPPSSDNPYMLYSVKENTAIGVGAYAKSPDQYFPFTQRSGRPSSFGFSWIPVLNPERTAYYLDSRDVSGTVVIDGKPKPFNYSIRAEYGRLFMGKRDFIQYLNFVFVPNEEFILESIQLDTTGGKITNSRITRIDYGLRVNTRSTEFRENVLLRDTLKSEFSIQETFDGISFKKNKNVELETDLPRVSSSAGMNSFGKKEKIKMNYGPKPYRTIVTTYPMEIVIPAYSWFSYDLWIVQHTVELKYKAVYRGVKSGKSINVSGVYSGYDFSNPYLEVYTRPNKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRF4</accession>
    <name>D7VRF4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994749.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13558"/>
    <dbReference type="EnsemblBacteria" id="EFK56355">
        <property type="protein sequence ID" value="EFK56355"/>
        <property type="gene ID" value="HMPREF0766_13558"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082124_0_0_10"/>
    <dbReference type="OrthoDB" id="949367at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107199" evidence="1">
        <location>
            <begin position="21"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="295" mass="33637" checksum="25CF365467EDF092" modified="2010-10-05" version="1">MKKISIITILTALFATPSFAQYKSESDTLMLAINEQNTISVKGVFNKKDTLNLNFDTGTTELVLTNNTMATKLKSKINLYNTAYPLELGHNLYTTKVYDAQLSGHGTDGRFGWDLFKGKAVELNYDKGIMVVHNQLPVAVNKDKTYSKHNIVFYKELFFMETRLRHSGVTVTDTILFDTGYQRTLMLNSDLLTAQKFPYKKMKEIKRVLMKGAQGNEIPVVTANLSTLKIGRHTLKNIPAQIANANKPFKEKDIHVLGNEVLKRFNVFLDFQDNNIYLQPNKYYNLAYIEAKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRL3</accession>
    <name>D7VRL3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">recR</name>
        <name evidence="9" type="ORF">HMPREF0766_13617</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RecR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994830.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13617"/>
    <dbReference type="EnsemblBacteria" id="EFK56414">
        <property type="protein sequence ID" value="EFK56414"/>
        <property type="gene ID" value="HMPREF0766_13617"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060739_1_1_10"/>
    <dbReference type="OrthoDB" id="1661836at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015967">
        <property type="entry name" value="Rcmb_RecR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01300">
        <property type="entry name" value="RECR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="81"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="7">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK56414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="204" mass="22829" checksum="229EEB49BA21E898" modified="2010-10-05" version="1">MEFSSKLLQQAVDEFGRLPGIGQKTALRLVLHLLKQSDGEVLRFTGALNQLKEQIKYCKECFNISDHDICEICSSLKRDKSLICVVEDTRDVMAIENTNQYQGVYHVLGGLISPMDGVGPSDLKIEGLVQRLRSGHVKEVILALSATMEGDTTIFYLYRKLKEFDIQISTIARGIAFGGELEYVDEITLGRSIATRVPYERNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRN9</accession>
    <name>D7VRN9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994898.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13643"/>
    <dbReference type="EnsemblBacteria" id="EFK56440">
        <property type="protein sequence ID" value="EFK56440"/>
        <property type="gene ID" value="HMPREF0766_13643"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_2_10"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="194"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="305" mass="35737" checksum="A60AAB61F28D4FD1" modified="2010-10-05" version="1">MEAKETLEEYYIRLCKPVPPEFGIYGANAAHFNILKRGNCFTTLNFARRDYYKIVLTRGKALLQTEKGEVLIDKPALFFSDRNIRFGWENLPEDQEGFTCLFNEYFITTTIRQSFRKLFSLFKDDVYPFLFLNDMQYEHLHQYFSSMQREYCSNFNDKDLLLKDLLNLVIYTAIKIKTTSMPLDSGIHQQDIVTRFMDLLDNQFPIESPVPGLQLRTPAHFADSLHIHVNHLNHSLKVKTGKTTSDWIKERILTEAVNLLLYSGWRISEIANGLGFEYPQHFNTFFKKHMGYSPRQYKLSSAAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRY9</accession>
    <name>D7VRY9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995160.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13743"/>
    <dbReference type="EnsemblBacteria" id="EFK56540">
        <property type="protein sequence ID" value="EFK56540"/>
        <property type="gene ID" value="HMPREF0766_13743"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1415">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061722_0_0_10"/>
    <dbReference type="OrthoDB" id="546749at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008482">
        <property type="entry name" value="DUF763"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38597">
        <property type="entry name" value="PTHR38597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05559">
        <property type="entry name" value="DUF763"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="401" mass="44658" checksum="7675E16117A9438A" modified="2010-10-05" version="1">MKRSGTADLPLHYGHVPLWLAERMGKLGLAIVEEIISHKGKNELLSRLSNPFWFQSLGAVMGMDWHSSGITTSVMGALKRSINPHAKEFGIYVCGGKGKLSRQTPLELARFAEYNGLDAADMVRCSKLAAKVDNTAVQDGFQLYQHNFVVSNEGQWTVIQQGMSDASSTARRYHWHSSAVQSFTEEPHTFIYGQNCGEILNLTDKAARPIKEAMLSVVAEDPRLILKELTHLVMPVHHDVRSENVDLKRLGSVLWLAQDNNIQHFEELLLLKGMGPRTLQSLALVSEVIHGSPARFRDPARFSFAHGGKDGHPFPVPVTVYDDTIQTLQNAIQRSRLGNSDKTQAIKSLSQVASRMEEGFTPNDNFDKVIEKERADSWKYGGRTVFGKAKPPLSAQLNLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRZ3</accession>
    <name>D7VRZ3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heavy metal efflux pump, CzcA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">czcA</name>
        <name evidence="5" type="ORF">HMPREF0766_13747</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995169.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13747"/>
    <dbReference type="EnsemblBacteria" id="EFK56544">
        <property type="protein sequence ID" value="EFK56544"/>
        <property type="gene ID" value="HMPREF0766_13747"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_10"/>
    <dbReference type="OrthoDB" id="91817at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004763">
        <property type="entry name" value="CzcA/CusA/SilA/NccA/HelA/CnrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00914">
        <property type="entry name" value="2A0601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="538"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="873"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="899"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="924"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="970"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1003"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1039"/>
            <end position="1056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1445" mass="159883" checksum="4D38792E953D1B15" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS13</accession>
    <name>D7VS13_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">pyrE</name>
        <name evidence="6" type="ORF">HMPREF0766_13767</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995214.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13767"/>
    <dbReference type="EnsemblBacteria" id="EFK56564">
        <property type="protein sequence ID" value="EFK56564"/>
        <property type="gene ID" value="HMPREF0766_13767"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074878_1_1_10"/>
    <dbReference type="OrthoDB" id="1280396at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="50"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="126"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK56564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="215" mass="23812" checksum="EDA982ECFB66742B" modified="2010-10-05" version="1">MNNLNEVEQKVAESLLQIKAIKLQPKSPFTWASGWRSPIYCDNRITLSYPAIRTYIRQKLSKLIQEEFGSVDMISGVATAGIPQGVLVAQDLGLPFTYVRSSAKDHGRQNLIEGEVVSGQRVVVVEDLVSTGKSSLQAVKALREAGCNVVGLVSIFSYGFDEAVQNFAEAKCAFFSLCDYDALIQVAAERNYIMEEDVDILRQWRISPSTWEAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS33</accession>
    <name>D7VS33_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4 8">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">fmt</name>
        <name evidence="11" type="ORF">HMPREF0766_13787</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Fmt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4 8"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13787"/>
    <dbReference type="EnsemblBacteria" id="EFK56584">
        <property type="protein sequence ID" value="EFK56584"/>
        <property type="gene ID" value="HMPREF0766_13787"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033347_1_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="9">
        <location>
            <begin position="18"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="10">
        <location>
            <begin position="223"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Tetrahydrofolate (THF) binding" evidence="8">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK56584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="325" mass="36325" checksum="D82CBBB3AFF9DC84" modified="2010-10-05" version="1">MSFGIEREFFNINQYLEMRIIFMGTPDFAVASLKALLDSGENVVAVVTVPDKPAGRGQKLHESAVKKFAVEHQIPVLQPVRLKDPEFLKELKAFNADLQVVVAFRMLPELVWDMPAKGTINVHGSLLPQYRGAAPINHAIINGEEKTGVTTFLLQHEIDTGNILFKGEVPITENDNAGTIHDKLMHKGAEVLLQTIKAMKADSLTPVPQDTLIEGTTLKHAPKIFKEDCLINWDKSTATVFNLIRGLSPYPAAFTYLDGKVLKIYEVQKEIAKPDIQAGRYVTDGKTYLKYATQDGYIHLKALQIEGKKRMLTDEFLRGYRFASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS87</accession>
    <name>D7VS87_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13841"/>
    <dbReference type="EnsemblBacteria" id="EFK56638">
        <property type="protein sequence ID" value="EFK56638"/>
        <property type="gene ID" value="HMPREF0766_13841"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_632890_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="444" mass="50373" checksum="B10316D2CEDE3BC0" modified="2010-10-05" version="1">MYIHITLYIIMNNMFYWLCGLLFLTGCHSSKRLENQKLSSAILTDTSLTHVDNLARSVIKEGFNAGSGYSQIWARDLNTFIETALEERSKEDVRGAILLFFALQQPNDEMVDGYVLKKDFTWNDDTPYYAAAAPDHVGFKNTVETDQETSLIQLVCKYIRKIGDYAILEEKVAGTTVLARMNKMIDYLMRERYNKQYGLLYGAMTADWGDVQPHDDFGCDWNELSNEAIDVYDNAMLIIALKDLCSVAPHAPEVQQWKKLQKSIHNNIRKYLWDTKNQKFIPHIYPGKSPLPDGFDENKIHYHGGTAIAIEAGVLSKKEIAVVNKQMVENVRLSGMPSIGLTLYPTYPEGFFRGGMSTAFVYQNGGDWTWFGGRMIQQLIANGFAHEAYTEVRPMLERVIRTQGFYEWYGKGNIPSGSGKFKGSAGVLSKAISQFKTWAEAQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS96</accession>
    <name>D7VS96_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cadmium-exporting ATPase</fullName>
            <ecNumber evidence="8">3.6.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cadA</name>
        <name evidence="8" type="ORF">HMPREF0766_13850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.3" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995428.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13850"/>
    <dbReference type="EnsemblBacteria" id="EFK56647">
        <property type="protein sequence ID" value="EFK56647"/>
        <property type="gene ID" value="HMPREF0766_13850"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_6_2_10"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK56647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="680" mass="73836" checksum="0BFB458DD934F38F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSB7</accession>
    <name>D7VSB7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995471.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13871"/>
    <dbReference type="EnsemblBacteria" id="EFK56668">
        <property type="protein sequence ID" value="EFK56668"/>
        <property type="gene ID" value="HMPREF0766_13871"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032WPI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1335150_0_0_10"/>
    <dbReference type="OrthoDB" id="2012229at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="194" mass="21873" checksum="CDB834F0BB988750" modified="2010-10-05" version="1">MRNLTLLMTIVFLFACKGTDKGNSDTKEYLSHEDMPNAATVYETIATTNVTDNTALLTFLQEKLKKSGFRFEEAKDRGGRSYNNCEDNKIISVGGKGIRSYFSRSNKPESGTKDIYPDFYILIYEFPTKDIAQENYAAIYNALYSGGAFCNGKAPEKLVINGNEIYHLSTCAEMFRTYTERYGDLIQNFGKGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSI3</accession>
    <name>D7VSI3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferritin</fullName>
            <ecNumber evidence="1">1.16.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ftnA</name>
        <name evidence="3" type="ORF">HMPREF0766_13937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Iron-storage protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 Fe(2+) + 6 H2O + O2 = 12 H(+) + 4 iron(III) oxide-hydroxide</text>
            <dbReference type="Rhea" id="RHEA:11972"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:78619"/>
            <dbReference type="EC" id="1.16.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ferritin family. Prokaryotic subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.2" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995590.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13937"/>
    <dbReference type="EnsemblBacteria" id="EFK56734">
        <property type="protein sequence ID" value="EFK56734"/>
        <property type="gene ID" value="HMPREF0766_13937"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1528">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065681_1_0_10"/>
    <dbReference type="OrthoDB" id="1890523at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01055">
        <property type="entry name" value="Nonheme_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041719">
        <property type="entry name" value="Ferritin_prok"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="PTHR11431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0409">Iron storage</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="9"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="175" mass="20312" checksum="59F06EF9223EC79E" modified="2010-10-05" version="1">MKDLLKLKSSLAQEIENILNAQIKVEAHSSALYLAMSSWCDDQGLDFSSDFFAKQSNEEREHMLKLFNYINNRGGRAVSPEITGIPTDFESFRSVFEQTLEQEMFVTEQFNQIADKCMKAKDYVTFNFVQWFLEEQVEEEYVARRILEMFDVIGEEGTGRWEIDKHVNKVALGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSN9</accession>
    <name>D7VSN9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Segregation and condensation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">scpB</name>
        <name evidence="4" type="ORF">HMPREF0766_13993</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995680.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13993"/>
    <dbReference type="EnsemblBacteria" id="EFK56790">
        <property type="protein sequence ID" value="EFK56790"/>
        <property type="gene ID" value="HMPREF0766_13993"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045647_5_3_10"/>
    <dbReference type="OrthoDB" id="1771906at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019345">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="186" mass="21272" checksum="2B51B7575DDE1C25" modified="2010-10-05" version="1">MKDVLLHIEAIIFASEEGITLNELKQVLEDALAISISKDEITDLVDRIKIKYQQEDYILELKLINNAYQFLTKPLYHESVNQLQSHKEKKKLSQSALETLAIIAYRQPITKLEVEQIRGVNCDYSIQRLLEKNLIQITGKSETIGKPLLYGTSTQFMNHFGINSTKDLPQLKDIVNEENTIGEIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VST7</accession>
    <name>D7VST7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA methyltransferase, RsmD family</fullName>
            <ecNumber evidence="3">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995796.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14041"/>
    <dbReference type="EnsemblBacteria" id="EFK56838">
        <property type="protein sequence ID" value="EFK56838"/>
        <property type="gene ID" value="HMPREF0766_14041"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0742">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075826_0_2_10"/>
    <dbReference type="OrthoDB" id="1827334at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00095">
        <property type="entry name" value="TIGR00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="181" mass="20510" checksum="F1E8F55DBEA203DE" modified="2010-10-05" version="1">MRIIGGTWGGIRLNPPSNLPVRPTTDIAKEALFNILQNRLDFDEIECLDLFAGTGNISFELASRGALSVQAVDLHFKCVQYIQDTAKKMKMETVQTKRADVFKFITSCKKQFDLIFADPPYDIPQLPQLPGLIIEGNLLKDNGLLIVEFPSTRRLDDSPYLLEIRKYGYSSFGFYSKQKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSU0</accession>
    <name>D7VSU0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995802.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14044"/>
    <dbReference type="EnsemblBacteria" id="EFK56841">
        <property type="protein sequence ID" value="EFK56841"/>
        <property type="gene ID" value="HMPREF0766_14044"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503359V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120456_0_0_10"/>
    <dbReference type="OrthoDB" id="1596895at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="188" mass="21985" checksum="8520C0C931088436" modified="2010-10-05" version="1">MPDKDNIELEKQIKRFLDVLKRNKQEYLSPIHSGKIDSRALFNLCFDYYDSNLPLHASWLLEKYVKAEPHQLQLLHADIITKLNDVRIEGSQRIFGNILICILDKRSNIVLNSDQEEIIIETIFNWMITPDKAVAVVANCFEILYYLSNKHSWVKEELAAQIEYFLKEGPPSIQSRGKKILSRIRKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSU3</accession>
    <name>D7VSU3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, group 2 family protein</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dpm</name>
        <name evidence="2" type="ORF">HMPREF0766_14047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995810.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14047"/>
    <dbReference type="EnsemblBacteria" id="EFK56844">
        <property type="protein sequence ID" value="EFK56844"/>
        <property type="gene ID" value="HMPREF0766_14047"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_13_0_10"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="243" mass="28002" checksum="DC0878CD19B1AAC6" modified="2010-10-05" version="1">MQQTDSLVIIPTYNEKENIEKIIRKVFSLAIAFDILIVDDGSPDGTADIVRKLQQEFPHHLHMEERKGKLGLGTAYIHGFKWGLGRNYEFIFEMDADFSHNPNDLLKLRQCCMDGADMSIGSRYVKGVNVVNWPMSRVLMSYFASVYVRFITGITIQDATAGFVCFRRRVLEKIPLDKIKFVGYAFQIEMKFTALQYGFNVVEVPIIFTDRTEGTSKMSTKIFREAFFGVIQLKIASWFKKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSZ4</accession>
    <name>D7VSZ4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995900.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14098"/>
    <dbReference type="EnsemblBacteria" id="EFK56895">
        <property type="protein sequence ID" value="EFK56895"/>
        <property type="gene ID" value="HMPREF0766_14098"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_52_1_10"/>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="85" mass="10076" checksum="27F07AE9027EEBAA" modified="2010-10-05" version="1">MKEIKVNRIKDVLEQKGATNNDLVRHLNVKKETVSRWVNNKQQPTVNTLNDIAEYLRVDIRDLLYPSNWKDSTIPPFEKEKNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT17</accession>
    <name>D7VT17_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Single-stranded DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ssb3</name>
        <name evidence="5" type="ORF">HMPREF0766_14121</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995963.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14121"/>
    <dbReference type="EnsemblBacteria" id="EFK56918">
        <property type="protein sequence ID" value="EFK56918"/>
        <property type="gene ID" value="HMPREF0766_14121"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078758_2_3_10"/>
    <dbReference type="OrthoDB" id="1942216at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="130" mass="14412" checksum="CAECA7B0645B9720" modified="2010-10-05" version="1">MNIIGRLTRDAEVRTLNNDKQVVNFSVASNESYKNKQGERVEQTTYFDCAYWLSANVARLLTKGTLVELTGRVNTRAWIGKDGEAHSGLNFHTSQIKLHGGSRRAETIQATAQAENNKVTAQGADDDLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT36</accession>
    <name>D7VT36_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996013.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14140"/>
    <dbReference type="EnsemblBacteria" id="EFK56937">
        <property type="protein sequence ID" value="EFK56937"/>
        <property type="gene ID" value="HMPREF0766_14140"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113992_0_0_10"/>
    <dbReference type="OrthoDB" id="1138684at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025415">
        <property type="entry name" value="DUF4141"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13605">
        <property type="entry name" value="DUF4141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107651" evidence="1">
        <location>
            <begin position="23"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="210" mass="23781" checksum="FFE91FC2F3FD1E14" modified="2010-10-05" version="1">MKKILFMVCTALMLAVAPSAKAQWVVTDPANLASGILNSANEIVQTSSTVSNVVKNFNEVKKVYEQGKEYYDKLKAVNNLVKDARKVQQTVLLVGDVSEMYVQNFGKMMNDPNFSPQELTAIGNGYSALLNESTELLKELKQIVTSSSLSLNDKERMDIIDRVYKEVKDYHSLVRYYTNKNISVSYLRAKKKNDAKRVLDLYGTANQKYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT87</accession>
    <name>D7VT87_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996128.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14191"/>
    <dbReference type="EnsemblBacteria" id="EFK56988">
        <property type="protein sequence ID" value="EFK56988"/>
        <property type="gene ID" value="HMPREF0766_14191"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZSHQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1276946_0_0_10"/>
    <dbReference type="OrthoDB" id="1893554at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107911" evidence="1">
        <location>
            <begin position="21"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="216" mass="24967" checksum="D082037797D3208F" modified="2010-10-05" version="1">MYKYSLFLFIALAVLKNSQAQTISNKSRSKIIAADFERIKDAIPEMENLYRMGTIHIKALQSNDSTAAFQIEETAYGDDIVAENQKEWKELISPAKKVENPSSIYMLISYTQKDKTLKVRPPKKDFYFPDYGVTWNLTVKKIKEKQTELVLTYESLSPEFKQKIDKEFKSDVYFKNVINKIAVNDKMLPIIENLLIKELRVDRESPAPMAAPRLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT89</accession>
    <name>D7VT89_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glutaminase</fullName>
            <ecNumber evidence="3 5">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">glsA</name>
        <name evidence="6" type="ORF">HMPREF0766_14193</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glutaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="3 5"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996134.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14193"/>
    <dbReference type="EnsemblBacteria" id="EFK56990">
        <property type="protein sequence ID" value="EFK56990"/>
        <property type="gene ID" value="HMPREF0766_14193"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027932_1_0_10"/>
    <dbReference type="OrthoDB" id="1288854at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00313">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="PTHR12544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03814">
        <property type="entry name" value="Gln_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK56990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="337" mass="37231" checksum="6FC4EE0E016A7131" modified="2010-10-05" version="1">MNRPYTSDLTKSTFVLVFFLITISTYAQKANTIKDISKAALTAVLDKNRNYYEDGKVADYIPELGKIDAKAVALAVVNDRGTVIGVGDINKKFTMQSISKTIALMLAVMENGEESVFKKMGYFGTDKPFNHFANLETMGKPLNPMMNAGAILTTSLISGDGQVPFDKILNMVRYITDNPTLDYSKTVYTSEKETGHRNRGMFYIMKNAGLISGSEEQLDNYFRQCSIELTAEDLAKIGYFFAHQCVRFDGDQRYKNPEMSKLIQSQMLIAGMYEFSGEYARTVGLPSKSGVGGGIMVSVPNQAGIAVFSAPLDSHGNSVVGYHMILDLVKQYNLGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTG8</accession>
    <name>D7VTG8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996354.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57069">
        <property type="protein sequence ID" value="EFK57069"/>
        <property type="gene ID" value="HMPREF0766_14272"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1554304_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="172" mass="20097" checksum="B73C98DF8810ED70" modified="2010-10-05" version="1">MKTIEFNQRNLKQVKVLLLPFAIYIILYFWILSSNERVIEWINQYSGPALGLALIFATPVFLPLFLILARMRTSTTVSFDEHRMTIQLKNGKQKEISYSQIHALKLNHPLPNTLTVSGSDNKVIYTFRPLNNDTPNKEILAELVRHINFRIDLLPPVKYFKVTFESRTYTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTH6</accession>
    <name>D7VTH6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57077">
        <property type="protein sequence ID" value="EFK57077"/>
        <property type="gene ID" value="HMPREF0766_14280"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3296692_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="40" mass="4387" checksum="537E2B66CFD98918" modified="2010-10-05" version="1">MFAGNIKIMIVVLTFFAVVIVVCVVSIGYLLVKGEQTEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTK1</accession>
    <name>D7VTK1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative arsenate reductase</fullName>
            <ecNumber evidence="3">1.20.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">arsC2</name>
        <name evidence="3" type="ORF">HMPREF0766_14305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ArsC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.20.4.1" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996411.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14305"/>
    <dbReference type="EnsemblBacteria" id="EFK57102">
        <property type="protein sequence ID" value="EFK57102"/>
        <property type="gene ID" value="HMPREF0766_14305"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116644_0_1_10"/>
    <dbReference type="OrthoDB" id="1650947at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008794">
        <property type="term" value="F:arsenate reductase (glutaredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006659">
        <property type="entry name" value="Arsenate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00014">
        <property type="entry name" value="arsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="116" mass="13743" checksum="1A9D503FCAD0B7B5" modified="2010-10-05" version="1">MIKIYHNNMCSKSRAALELLKACTTDLEVHEYITDTPDKEELTRILDMLQLKPIELIRRKEAIFEEKFKDILYTDEEWIDIMLQYPVLIERPIVVKDGKAVIGRPIERVIDLLRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTL6</accession>
    <name>D7VTL6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14320"/>
    <dbReference type="EnsemblBacteria" id="EFK57117">
        <property type="protein sequence ID" value="EFK57117"/>
        <property type="gene ID" value="HMPREF0766_14320"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2791858_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="68" mass="8027" checksum="F24D508EF9A6B598" modified="2010-10-05" version="1">MKPKRRIERAELCEKQTEDHLLKKINDRFHNADVLNNSITYTYIIKLRSFCISNIKGILSFQLAMQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTN5</accession>
    <name>D7VTN5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001670.1">
        <property type="nucleotide sequence ID" value="NZ_GL379777.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14355"/>
    <dbReference type="EnsemblBacteria" id="EFK55794">
        <property type="protein sequence ID" value="EFK55794"/>
        <property type="gene ID" value="HMPREF0766_14355"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50337E8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141053_0_0_10"/>
    <dbReference type="OrthoDB" id="1410131at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107289" evidence="1">
        <location>
            <begin position="21"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="159" mass="17707" checksum="23FDFB2DF162EAA2" modified="2010-10-05" version="1">MKKIFLLFAVFAVILLPAKGQQELSASKGGSSWIWGPSVGYQYQKGNFLKVSGWGLFAPNDNQYMKIDAGANFTWMMDKTTVIPELGFTYYLSDKGVWPFIKGEITPYTVTPKAGVSLLSLIDIGVGYGFDMQTKDNFKPLKGFTTSISVNVPFNFFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTV9</accession>
    <name>D7VTV9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent DNA helicase, RecQ family</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recQ2</name>
        <name evidence="7" type="ORF">HMPREF0766_14429</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002272.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14429"/>
    <dbReference type="EnsemblBacteria" id="EFK55738">
        <property type="protein sequence ID" value="EFK55738"/>
        <property type="gene ID" value="HMPREF0766_14429"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001103_9_7_10"/>
    <dbReference type="OrthoDB" id="54580at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="24"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="213"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK55738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="631" mass="72978" checksum="97158B54ECF08F7A" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTY5</accession>
    <name>D7VTY5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mraW</name>
        <name evidence="6" type="synonym">rsmH</name>
        <name evidence="8" type="ORF">HMPREF0766_14455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002302.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14455"/>
    <dbReference type="EnsemblBacteria" id="EFK55764">
        <property type="protein sequence ID" value="EFK55764"/>
        <property type="gene ID" value="HMPREF0766_14455"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038422_2_0_10"/>
    <dbReference type="OrthoDB" id="1272633at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="34"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK55764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="303" mass="34084" checksum="73E51ABA01EFC35B" modified="2010-10-05" version="1">MSNVYHVPVMLKECIDALSIKPDGVYVDVTFGGGGHSREILKHLGPKGRLFAFDQDPDALENTIADERFTLIHQNFRFLKNNLRLNGVKEVDGILADLGVSSHQFDAADRGFSIRFDADLDMRMDQVSDLDAKKVLNTYAEEDLHRIFGMYGEIMNAKSLAKTVVTARLSAPIETVAGLKEVIRKLVPKGKEHKYHAQVFQALRIEVNKELEALQEFLLQTVSTLKPSGKLVVMSYHSLEDRLVKNFMAKGKFKGEVEKDFFGNEIKPFQVITRKAITASEEELSTNNRSRSAKLRVAEKMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTY9</accession>
    <name>D7VTY9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14459"/>
    <dbReference type="EnsemblBacteria" id="EFK55768">
        <property type="protein sequence ID" value="EFK55768"/>
        <property type="gene ID" value="HMPREF0766_14459"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZUZ7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1721178_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="152" mass="17972" checksum="C8374FA51EF97D34" modified="2010-10-05" version="1">MDGIENYLNIVHYCLYKAEYRLHLLFNKINPERLLIWLLMKIPFVKRRYEKMGVTRQSINRDNNNLWGDKRFGLSTVAAGGFLWGGLALFFFSVLMMLKVSISTLLIIGCGVGSGLICYVFVFRQDKYIKYFDRYEKWSKQEKRKYGWLTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTZ2</accession>
    <name>D7VTZ2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RHS repeat-associated core domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14462"/>
    <dbReference type="EnsemblBacteria" id="EFK55771">
        <property type="protein sequence ID" value="EFK55771"/>
        <property type="gene ID" value="HMPREF0766_14462"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_729376_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="379" mass="41463" checksum="DBADD5E43F2B7598" modified="2010-10-05" version="1">MSLCYKNNKLRKTANTSGQRDYTGGIEYQNGVIELIHTAEGVAYRNANGTYSYRYNLTDHLGNVRATIYRNPNTNAVEVLQRDDYYPFGLQKSPSPVYGNNKYLYNGKEKQEELGGQLDYGARFYDPVIGRWNVVDPLAEKMRRHSPYNYAFDNPIRFIDPDGMESKDWIKWKSERGTTYYTYDRNVTSVAQAKDKGYTNVDWVKESASVATTSGSSYNMNKGGAFTKDGSSGNIDLSEGGAVANGGAVRINTAKSGAQQIGEPISALGDATSTVGDITTYSGLISLQPEIVAAGGSIGRLGMALEISGNLISNDFSKESFVEGGQKLGSHVVFNKISEKGVDATRKVAGGKDNRVSESIIQGVVDVWNKIFDKTIVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTZ9</accession>
    <name>D7VTZ9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000015">
        <property type="protein sequence ID" value="EFK55694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001779.1">
        <property type="nucleotide sequence ID" value="NZ_GL379777.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14469"/>
    <dbReference type="EnsemblBacteria" id="EFK55694">
        <property type="protein sequence ID" value="EFK55694"/>
        <property type="gene ID" value="HMPREF0766_14469"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161891_0_0_10"/>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="92" mass="10532" checksum="540741242699FFB0" modified="2010-10-05" version="1">MNSFGEYLRNKREKLGLPLRKVAAELDIDTSILSKIERSERVATKEMLPTLAKTLEVHEKEIQIEFIQSTVFSELGDLEFLADGLKNILKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VU00</accession>
    <name>D7VU00_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase C-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000015">
        <property type="protein sequence ID" value="EFK55695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001781.1">
        <property type="nucleotide sequence ID" value="NZ_GL379777.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14470"/>
    <dbReference type="EnsemblBacteria" id="EFK55695">
        <property type="protein sequence ID" value="EFK55695"/>
        <property type="gene ID" value="HMPREF0766_14470"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008466_1_0_10"/>
    <dbReference type="OrthoDB" id="291634at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="260"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="676"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK55695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1087" mass="125850" checksum="9EA1681ADCB536D6" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGC1</accession>
    <name>D7VGC1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001921.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10040"/>
    <dbReference type="EnsemblBacteria" id="EFK60096">
        <property type="protein sequence ID" value="EFK60096"/>
        <property type="gene ID" value="HMPREF0766_10040"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134973_7_3_10"/>
    <dbReference type="OrthoDB" id="2061355at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="1">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="70" mass="7784" checksum="64E35BF709496EAA" modified="2010-10-05" version="1">MNDTLKFKTNIKCSSCVAKVTPFLDAEEGIKQWQVDTTTADKILTVETNGMTESEIKEAVEKLGFKIESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGE4</accession>
    <name>D7VGE4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10063"/>
    <dbReference type="EnsemblBacteria" id="EFK60119">
        <property type="protein sequence ID" value="EFK60119"/>
        <property type="gene ID" value="HMPREF0766_10063"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2345250_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK60119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="97" mass="11026" checksum="42F6DEE45D7CDF69" modified="2010-10-05" version="1">MSTSKFDKIIKGMENVTGNAQKCKFGETIVSFGGEKFSLFDFGTVSDTKHGAIYLGTSKEGTEYTWSKDGLYETPKVRSINYLKNEYSEVVKYYNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGF7</accession>
    <name>D7VGF7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002009.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK60132">
        <property type="protein sequence ID" value="EFK60132"/>
        <property type="gene ID" value="HMPREF0766_10076"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50335SQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1833514_0_0_10"/>
    <dbReference type="OrthoDB" id="1994830at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK60132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="140" mass="17079" checksum="5A11625A06DCAE26" modified="2010-10-05" version="1">MARFIIRTHTPRTDHQAPHIFILNKGMNSGKPLTTPCPNSFVILFNTQTDREEYYWLAYSLWQAKFWHPYLTGSVIPFLRLSEFRKEFIKQTTHMLQNTEKHEKSIESLRLLKDAEERFRYNIRLVEDLRRMILYRYIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGN3</accession>
    <name>D7VGN3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996736.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10152"/>
    <dbReference type="EnsemblBacteria" id="EFK59235">
        <property type="protein sequence ID" value="EFK59235"/>
        <property type="gene ID" value="HMPREF0766_10152"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111475_0_0_10"/>
    <dbReference type="OrthoDB" id="1791395at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021533">
        <property type="entry name" value="PepSY-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11396">
        <property type="entry name" value="PepSY_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepSY_like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="PepSY_like" evidence="1">
        <location>
            <begin position="60"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="144" mass="16396" checksum="CB1D1B0AC73C5230" modified="2010-10-05" version="1">MRKLIIAPLLVMLTVFVSCDKDEVMDPTKLPAKVQDYIAAHFSDAHISRVEQDKGDSNSYYEVYLSTGYELDFNKSGDVYGIDGNTKRLPDSVVPEKLSTYVSANYKTFFVVKWELGRLEQEIKLNNGIELVFDLNGEFKNVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGW4</accession>
    <name>D7VGW4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_10233</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996944.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10233"/>
    <dbReference type="EnsemblBacteria" id="EFK59316">
        <property type="protein sequence ID" value="EFK59316"/>
        <property type="gene ID" value="HMPREF0766_10233"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_5_0_10"/>
    <dbReference type="OrthoDB" id="881796at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK59316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="265" mass="28739" checksum="EEC70B1FF7503833" modified="2010-10-05" version="1">MELLAYLLAVLIGISLGLIGSGGSILTVPILVYILDIDPILATAYSLFIVGMTSLAGGISQTISKQVDYKMVLLFGIPSIIMVLFTRGYIMPHIPQEIGRVGDFVLTKGMFVMVLFAVIMLFASVSMIRSKEKTFVAEKQRYDNKSIILKGAFLGVITGMVGAGGGFLIIPTLVLFAGMQMKKAIGTSLMIIAFNSLIGFIGFVEIDGHEVDWRLLFLFSIAAIMGILIGTLLSRKISGSNLKISFGWFVLIMGIMILVREIVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH34</accession>
    <name>D7VH34_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Creatinase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_10303</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997129.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10303"/>
    <dbReference type="EnsemblBacteria" id="EFK59386">
        <property type="protein sequence ID" value="EFK59386"/>
        <property type="gene ID" value="HMPREF0766_10303"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011781_2_4_10"/>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="3">
        <location>
            <begin position="7"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="2">
        <location>
            <begin position="311"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24_C" evidence="4">
        <location>
            <begin position="532"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="591" mass="65286" checksum="1A0217172A89760C" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH43</accession>
    <name>D7VH43_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_10312</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997147.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10312"/>
    <dbReference type="EnsemblBacteria" id="EFK59395">
        <property type="protein sequence ID" value="EFK59395"/>
        <property type="gene ID" value="HMPREF0766_10312"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002934_0_3_10"/>
    <dbReference type="OrthoDB" id="439010at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001092">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106937" evidence="6">
        <location>
            <begin position="22"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="site" description="May be important for catalysis" evidence="5">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001092-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="464" mass="53018" checksum="6B9C2F705E2FB28E" modified="2010-10-05" version="1">MKKIRLILILINIIVSLPGSAQEFIQAKSETYVTPTDPAVIKKLEQWQDLKFGMFIHYGLYTQAGATGLSNQGSSWSLTNMSFVQRDTTMEYSDFKQKYFSQINSFNPQKLNPEKLARLGKKAGMKYLIFTSKHHDGFNLFDTRQTNFSIMHGAYKNNHNANILKYFFEAFRKQGYMVGAYYSKPDWHSPYYWWDKYPTSNGGENYNTREYPERWDKFIQFTNNQVAELTNGDYGNVDILWIDAWGQEWGMNRKAEIARSKQPGILIIERGTPGTGYEDYQTPEQGIPKEQMSHPWESCITLGKRWSYVPADEQYFKSSAQVIHTLVEIVAKGGSLLLGFSPKADGTIAQSIIDRLEEIGKWTSRNGEAIYNTRNTEIYHRGNTWFTQSKDGKKIYAITNLEEGKAIPSTVTWQGNEPAGGSVIKCLQTGKKVVWKKTENGIEITLPKELPDNLPAVAFVLTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHB7</accession>
    <name>D7VHB7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glucose/galactose transporter WARNING</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">gluP</name>
        <name evidence="13" type="ORF">HMPREF0766_10386</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Intake of glucose and galactose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997303.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10386"/>
    <dbReference type="EnsemblBacteria" id="EFK59469">
        <property type="protein sequence ID" value="EFK59469"/>
        <property type="gene ID" value="HMPREF0766_10386"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028452_2_2_10"/>
    <dbReference type="OrthoDB" id="1121832at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005354">
        <property type="term" value="F:galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005355">
        <property type="term" value="F:glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005964">
        <property type="entry name" value="Glc/Gal_transptr_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01272">
        <property type="entry name" value="gluP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFK59469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="427" mass="46825" checksum="894A9E1376917F7C" modified="2010-10-05" version="1">MTNKPLNKRDTAISVGIIGMMFFIFGFVSWINAILIPYFKIACELTNFQSYLVAFAFYISYLVMSLPSSFLLKKIGFKKGIMVGFWTMALGALIFVPAAYSRAYPVFLLGLFTLGAGLAILQTVANLYITVVGNKERAAQRISIMGICNKGAGILAPLAFSAAILRPTDGELFREIPLMSDVVRATVLDELIMRVVIPYTIVACVLFIIGIAVRYSPLPELTLEDDTDNKAGKKNILQFPHLVLGAIAIFLHVGTQVIAIDTVISYADTMGLTLIEAKVFPSYTLTATIVGYLLGIVVIPRFISQRSMLKICTLTGLLLSLSIHLFHGQVDWLNHHVDISIWFVVLIGLPNALIWAGIWPLALDGLGKYAKEGSALLIMGLCGNAILPLIYGIVADVSNVQTAYAVLIPCFLYLVFYAFIGHKIKNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHH2</accession>
    <name>D7VHH2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">secY</name>
        <name evidence="11" type="ORF">HMPREF0766_10441</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997460.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10441"/>
    <dbReference type="EnsemblBacteria" id="EFK59524">
        <property type="protein sequence ID" value="EFK59524"/>
        <property type="gene ID" value="HMPREF0766_10441"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030313_0_0_10"/>
    <dbReference type="OrthoDB" id="1567535at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK59524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="446" mass="48629" checksum="709DAC4D51EF3DDA" modified="2010-10-05" version="1">MKKLITTLTNIWKIEDLRNRILNTLLFLLIYRVGCHIVLPGVNPAALASGHKEGLLGLLDMFAGGSFSRSAIFALGVMPYISASIVVQLLGIAVPYFQKMQKEGESGRKKMNQITRYLTLAITLVQAVAYVKTQIEPGARIIADPMFTILSTFVLTAGTLFVMWLGEKITDKGIGNGISLIIMAGIIAQLPSGITAEWVTRMSPNGGGPIPLLLEFLALFFVVIFTILIVQGVRKIPVQYAKKIVGNKQVGGVRQYIPLKVNAAGVMPIIFAQAIMFVPMSLSQFFPGMQSDFLTSLSNYTSVAYNVTFAVLIIAFTFFYTAIMVNPQQMSEDMKKNGGFIPGIKPGYDTNLYIDRVISNITFPGAVFLAIIAILPAIASLFGINNQFAHFYGGTSLLILVGVVLDTLQQIESHLLMRHYDGLMKTGRIKGRSTSATVEGIDQSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHK2</accession>
    <name>D7VHK2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="5">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pdhC</name>
        <name evidence="9" type="ORF">HMPREF0766_10471</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997515.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10471"/>
    <dbReference type="EnsemblBacteria" id="EFK59554">
        <property type="protein sequence ID" value="EFK59554"/>
        <property type="gene ID" value="HMPREF0766_10471"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_2_10"/>
    <dbReference type="OrthoDB" id="1626282at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="PTHR23151"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="127"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="8">
        <location>
            <begin position="254"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="209"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="548" mass="57797" checksum="2BDC3BBA381103B2" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHS7</accession>
    <name>D7VHS7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997689.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10546"/>
    <dbReference type="EnsemblBacteria" id="EFK59629">
        <property type="protein sequence ID" value="EFK59629"/>
        <property type="gene ID" value="HMPREF0766_10546"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZCMH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090649_0_0_10"/>
    <dbReference type="OrthoDB" id="1371551at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="250" mass="29052" checksum="F242080365CE5CEB" modified="2010-10-05" version="1">MQAQAQEADSTKTEEARPSAKTHKHSYTLGKGDKETHIVYPRTFYGITFARVDWGFSRMIDNGSFTLSDDNQFLNYKKGKTTNFGFDIAQFGVRMNDNFRMYISTGFEWNYTRLKENVILKKNTTPLDYEILDRNEVNIEKNRLTSTYLRIPLTFELRSRKMANGDRLKVAFGPIGGVLLKGSQRLKSEENGKQKFRDDYNLQSFQYGAFVRAGFRDVGFFTKYYFNDVFENSPNQKGLNNFTFGLTLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHT0</accession>
    <name>D7VHT0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_S9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997697.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10549"/>
    <dbReference type="EnsemblBacteria" id="EFK59632">
        <property type="protein sequence ID" value="EFK59632"/>
        <property type="gene ID" value="HMPREF0766_10549"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_5_1_10"/>
    <dbReference type="OrthoDB" id="1470522at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="103"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="288" mass="32269" checksum="DC1567C9DD44FDF1" modified="2010-10-05" version="1">MKTLIVINLVLMIALRAVAQEKILLYPEGIPNSKGENSEEYQKNIPELFIYKPTVADKHVGILVIPGGGYAHVAIGHEGHDVARELNKNGYTAFVLKYRLPSDQIMKDKKIGPLQDAQRAMQLIRENQQVLGVDIRKLGVMGFSAGGHLASTLSTHYKKAYIANDLNTDLRPDFSILCYPVISMDTTITHAGSRKNLLGPNPEKEDEILFSNELQVDKNTAPAFLMSAKDDKAVPVENMYRYQRALQKYKIPNEVFTYENGGHGFGLNNKTSEVKWLAPCLTWLEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHU2</accession>
    <name>D7VHU2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997732.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10561"/>
    <dbReference type="EnsemblBacteria" id="EFK59644">
        <property type="protein sequence ID" value="EFK59644"/>
        <property type="gene ID" value="HMPREF0766_10561"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_694277_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="397" mass="45696" checksum="A658E599D28E18AC" modified="2010-10-05" version="1">MKCRYFLIILSILGLYLLPGKVVAQTDSIVTFESFDYDIYGNITYSSVNGYLFSSGRTERYKKENFITYAPQYYASVNPSIQNLLEKRILNKQISNTGSRSNDNGNSWVTSNQSFYVYDDTFGLYPIAEYYLPQGATANVPMPDFNLHTPDIDNRFRRAYAVELMDSKGRPIQVSDRAGIASCYLYSQEGQLTCQVDNGKLSDIAYTGFEVVEESFNTGWTFTDLQTNSMFLMPMYGSARFYQCESMNLDVNKTYILSLWCAIDNPSHSEMGYHIVTSGGSHTLLDTMMVVNPDAPNGAMFFKKFTFSIKNAIQVSLQSNPTAAGNYYIDELRLHPQESQMKTYRYERINGVHRVVRSADSRHDLEWLKYDNLGRLYQRYDKNLKLTLEKEYTRWTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHU9</accession>
    <name>D7VHU9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997752.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK59651">
        <property type="protein sequence ID" value="EFK59651"/>
        <property type="gene ID" value="HMPREF0766_10568"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_626853_0_0_10"/>
    <dbReference type="OrthoDB" id="2228857at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="437" mass="50651" checksum="161852BA2D62C848" modified="2010-10-05" version="1">MAIIISLIFLGSLIGFVLGLIKPSLVVKFKLPKTRLISSAIYGGIMILSGIVISNMPEDNTPNNINHRNDYLEKWNNLSDKKITGYINEKIVGEWHLDFAVFQDYNTGEITKVNHHSRKQGNQSVYLEKFEDKQYLVFEGTGNEHLSQSYKTHFNIKGDSLFIDLTDRYKVMYISPNLLVRKQFDVKMNTSMIEVLYKDSTSFKDERNQYFNYLNTENRKRMIEANLIIDNNDSTNFANAHSTIINCLISDKLNSIINENVSNKGKDSLSSATQINLDKIDKYINEFWFLKFKSLFESVPKEPGGDIYIGKVNNILYHLNADMVKRKILKLDNKIYSTLYNSKLTEIEKFKSEYKIYGDGGDTFLRLAAEDYIVNHLKDPNSLKIVDAYINKKANEGWVYYIKYRAKNSFGAYNLEDALILIKYDPKSKLYYGVRHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHX3</accession>
    <name>D7VHX3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997816.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10592"/>
    <dbReference type="EnsemblBacteria" id="EFK59675">
        <property type="protein sequence ID" value="EFK59675"/>
        <property type="gene ID" value="HMPREF0766_10592"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032RR7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114082_1_0_10"/>
    <dbReference type="OrthoDB" id="1651617at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007485">
        <property type="entry name" value="LPS_assembly_LptE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04390">
        <property type="entry name" value="LptE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="174" mass="19637" checksum="7BDE6EB9E117C690" modified="2010-10-05" version="1">MRKLKQVYLNLIITATVMLFTVSSCGVKYSFTGGSIPADMKTVNVQFFENIAPMVYATLSQNFTEALKTRFRNQTRLSQVNTGGDAIFEGFITNYTITPAAVEARTDMAALNRLTITVKVTYTNQKKPEDGFSEQTFTRFKDFSGTVQSQEEGLTKDIIEMLTEDIYNRAFANW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIL7</accession>
    <name>D7VIL7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998298.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10836"/>
    <dbReference type="EnsemblBacteria" id="EFK59919">
        <property type="protein sequence ID" value="EFK59919"/>
        <property type="gene ID" value="HMPREF0766_10836"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070070_0_1_10"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="274" mass="29789" checksum="D1A3CE55675F92E3" modified="2010-10-05" version="1">MKNTILSLSLSFLCVTMAEAQHQLKEIWRTQEEMPVPESVLAVPDKQLYVSLIDGGGSERDGKGGVALLHTDGTVKDKDWATGMNAPKGLGLHNNKLYVADIDHVVVVDAKSGKLLEKIPVPDATFLNDIAIDAKGTVYVSDTRLGKVFKLTNHKPEVFLEVVQSANGLLVVGDNLLVLAGPELWSVNTKTKEKQIIAEGFEHGGDGIEAVGNGDYIVTCWPGVVYYVKADGNFEKLLDVEGEFNTADLGYDARKKIVYIPTFNGNSVIAYQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIM7</accession>
    <name>D7VIM7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10846</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998319.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10846"/>
    <dbReference type="EnsemblBacteria" id="EFK59929">
        <property type="protein sequence ID" value="EFK59929"/>
        <property type="gene ID" value="HMPREF0766_10846"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046535_2_1_10"/>
    <dbReference type="OrthoDB" id="1900582at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025645">
        <property type="entry name" value="DUF4349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14257">
        <property type="entry name" value="DUF4349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005672179" evidence="3">
        <location>
            <begin position="24"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="168"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="283" mass="31685" checksum="F6BE86BB93FAAD69" modified="2010-10-05" version="1">MKNVQRILLIGSAVLILFSCNRASDTSKVALSEPDAAAEPMALSLEDQSEPDAAVDAAANERLIVPQKKIIKTGSVSVESRDVAKSKKDLDALVSKHKGFYEEETLSKGNSIASYNLNIRIPVQSYEAFIAELESGKDNITSKSIQSQDMTGQYYDLDSRLKSKKAYLQRYTELLSKARNVKEILEIEEQIRVIQEEIDATAASLKSLNEQVAYSTLSVYLYQEQSNISIGADSFGTKLVDAVRFGWTALETFFIILIRIWPFLLIGVLGFVVIRKYKKRRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIT0</accession>
    <name>D7VIT0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998432.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10899"/>
    <dbReference type="EnsemblBacteria" id="EFK59982">
        <property type="protein sequence ID" value="EFK59982"/>
        <property type="gene ID" value="HMPREF0766_10899"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2604276_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045938">
        <property type="entry name" value="DUF6358"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19885">
        <property type="entry name" value="DUF6358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="79" mass="8915" checksum="025F107779CE3E61" modified="2010-10-05" version="1">MKKEIIYNVGLNVGMMLLIMIGYTAYKSGNALIFGLSIALGVVFIYLKIVLLKQVRRKTRTPQEVPVKTSTTKKKKKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIU8</accession>
    <name>D7VIU8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">gmk</name>
        <name evidence="11" type="ORF">HMPREF0766_10917</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998468.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10917"/>
    <dbReference type="EnsemblBacteria" id="EFK60000">
        <property type="protein sequence ID" value="EFK60000"/>
        <property type="gene ID" value="HMPREF0766_10917"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001715_1_1_10"/>
    <dbReference type="OrthoDB" id="1502854at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="3"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK60000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="190" mass="21860" checksum="EB8B62979F1C5E90" modified="2010-10-05" version="1">MKGKLIIFSAPSGAGKTTIVRHLLNKYPDKIEFSISASTREPRGEEVDGKDYYFISKDEFLHKIAKQEFIEFEEVYSGTFYGTLRSEVERIWEKGKHVIFDIDVVGGLRLRSKFPDQALSIFVQPPSLEVLKDRLRGRGTDSEDKLKERFAKAEHELSFADRFDVILKNYDLDTACAEAEKLLLDFIDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIW3</accession>
    <name>D7VIW3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ScpA/B protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">scpA</name>
        <name evidence="2" type="ORF">HMPREF0766_10932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998502.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10932"/>
    <dbReference type="EnsemblBacteria" id="EFK60015">
        <property type="protein sequence ID" value="EFK60015"/>
        <property type="gene ID" value="HMPREF0766_10932"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1354">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038686_3_1_10"/>
    <dbReference type="OrthoDB" id="959677at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01805">
        <property type="entry name" value="ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="262" mass="31277" checksum="5F771A7602E66201" modified="2010-10-05" version="1">MNASEGYEIKLDQFEGPFDLLLFFIERDELNIHDIAISKITDDFLDYIQKMQALNIELASEFIFVASTLMRIKAKMLLPRPDLDENENEIDLKKELVQKLILYKQFKNICEDLKGLEENRLRYHLRGNIGYDLKNTNRPVQDGEELSSFDLYKLMMVYERMMYHYANRVQEVKHTVVKYPYTIEQQKRVIKELIEMNEKLDFNSIRKSSENKVHFVYNFLAILEMLQQRLLEIEVGLGYNNFWVEKKDPNVPDPEVLEMEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ02</accession>
    <name>D7VJ02_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK60054">
        <property type="protein sequence ID" value="EFK60054"/>
        <property type="gene ID" value="HMPREF0766_10971"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_213879_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK60054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="53" mass="6378" checksum="2DA4A26B3F2A7967" modified="2010-10-05" version="1">MQERKEIEKIPIEEAMELLREIGTDVEQETAELIMEFLYNLTMIIIRECFDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ12</accession>
    <name>D7VJ12_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002097.1">
        <property type="nucleotide sequence ID" value="NZ_GL379779.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10981"/>
    <dbReference type="EnsemblBacteria" id="EFK59147">
        <property type="protein sequence ID" value="EFK59147"/>
        <property type="gene ID" value="HMPREF0766_10981"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_106_4_10"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="3">
        <location>
            <begin position="473"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="441"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="678" mass="78551" checksum="1A82D838AF965218" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ18</accession>
    <name>D7VJ18_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10987"/>
    <dbReference type="EnsemblBacteria" id="EFK59153">
        <property type="protein sequence ID" value="EFK59153"/>
        <property type="gene ID" value="HMPREF0766_10987"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3222235_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="44" mass="5050" checksum="19591E8698CD005D" modified="2010-10-05" version="1">MSGGGLADKSCSLKRFIISKNICRKVYFDFQAYYGLKNYIIAYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ36</accession>
    <name>D7VJ36_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA methyltransferase, TrmH family, group 3</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rlmB</name>
        <name evidence="2" type="ORF">HMPREF0766_11005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002146.1">
        <property type="nucleotide sequence ID" value="NZ_GL379779.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11005"/>
    <dbReference type="EnsemblBacteria" id="EFK59171">
        <property type="protein sequence ID" value="EFK59171"/>
        <property type="gene ID" value="HMPREF0766_11005"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_0_1_10"/>
    <dbReference type="OrthoDB" id="1422015at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="18"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="259" mass="28511" checksum="C9DE5A27CC1CC7BC" modified="2010-10-05" version="1">MQNFQRHDRSEKRESNQMVFGIRAVIEAIDSGKEIESLFVQRGLGGSLFLELKSLIKEHEIGFQQVPIEKLNRITRKNHQGVIAVISPITYQKIEDLIPEIYEKGETPLILMLDGVTDVRNLGAIARTAECSGVHAIIVPKKGSAEINPDAIKTSAGALYKIPVCRHDNLGKVGKFLIDSGIQLVVSTEKTEESIYSVDYTAPTCIIMGAEDIGVSDDLIRISDHLAKIPMFGEIGSLNVSVSAGVVLYEAIRQRQITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ52</accession>
    <name>D7VJ52_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine triad domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hit</name>
        <name evidence="3" type="ORF">HMPREF0766_11021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002180.1">
        <property type="nucleotide sequence ID" value="NZ_GL379779.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11021"/>
    <dbReference type="EnsemblBacteria" id="EFK59187">
        <property type="protein sequence ID" value="EFK59187"/>
        <property type="gene ID" value="HMPREF0766_11021"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_3_1_10"/>
    <dbReference type="OrthoDB" id="1934382at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="4"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="137" mass="15289" checksum="57787218CE734A8F" modified="2010-10-05" version="1">MSTLFSKIVAGEIPAHKVAESIDYLAFLDIQPLTRGHVLVIPKRETDYIFDISDDEYMGLWIFAKIVAQGIKKVFPCRKVGIAVVGLEVNHAHIHLIPLNAVHDMNFEKPKLSLPDEELAKIAEDIREAIASVTNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ88</accession>
    <name>D7VJ88_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1 2">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">pth</name>
        <name evidence="4" type="ORF">HMPREF0766_11057</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PTH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1 2"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000455.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11057"/>
    <dbReference type="EnsemblBacteria" id="EFK58941">
        <property type="protein sequence ID" value="EFK58941"/>
        <property type="gene ID" value="HMPREF0766_11057"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062456_4_1_10"/>
    <dbReference type="OrthoDB" id="1676462at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="186" mass="20687" checksum="72E73C3697189895" modified="2010-10-05" version="1">MNYLIVGLGNIGREYQDTRHNIGFMVADELVAQAGGSFSTLKHAYYAEYKQRGHNVYVIKPTTYMNLSGKAVNFWMQQLKVPIANLLVIVDDLALPFGTIRLKPKGSSAGHNGLKSIEALCGGQAYPRLRFGISDNFPKGRQADYVLAPFDNDEQKELPALIERSVQMANSFINIGIELTMTNMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ98</accession>
    <name>D7VJ98_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000485.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11067"/>
    <dbReference type="EnsemblBacteria" id="EFK58951">
        <property type="protein sequence ID" value="EFK58951"/>
        <property type="gene ID" value="HMPREF0766_11067"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2156751_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="111" mass="12583" checksum="A23DBD787411A7E5" modified="2010-10-05" version="1">MYMIFESQQIVYSLEDNWDELVSITFVNAENYLSLSSLAYEDEIGIEINDQTNCISALKSGFKYEFAETSIHFTIENPIIQNNVPDLKFVVNFSTKDADKLKSAVNALVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJP1</accession>
    <name>D7VJP1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetolactate synthase small subunit</fullName>
            <shortName evidence="8">AHAS</shortName>
            <shortName evidence="8">ALS</shortName>
            <ecNumber evidence="8">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ilvN</name>
        <name evidence="10" type="ORF">HMPREF0766_11210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000779.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11210"/>
    <dbReference type="EnsemblBacteria" id="EFK59094">
        <property type="protein sequence ID" value="EFK59094"/>
        <property type="gene ID" value="HMPREF0766_11210"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0440">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055003_3_1_10"/>
    <dbReference type="OrthoDB" id="1500398at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="7"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK59094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="196" mass="22766" checksum="1478A41B092A4EEE" modified="2010-10-05" version="1">MEKQEFTITLYTENSIGLIGRISTIFSRRKINIESLNTSPSEVEGIHRFTIVITETEEVLRKLCRQLEKQVDVLKAYYNTNDEVIWQEQALYKVPTDIVAEKAPVERLLRQYGASAVVIRNDYTVFETAGHREEIDKLTEELTKYGLIEFVRGARIAIIKDSAGFHSKLLQFEKKQPSEEIVENEYLDQRDNVFTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJW6</accession>
    <name>D7VJW6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11285"/>
    <dbReference type="EnsemblBacteria" id="EFK58568">
        <property type="protein sequence ID" value="EFK58568"/>
        <property type="gene ID" value="HMPREF0766_11285"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044440_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005672178" evidence="2">
        <location>
            <begin position="20"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="279"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="320" mass="36672" checksum="70EC7FDD32F97010" modified="2010-10-05" version="1">MRALLLILWISVLNTLAEAQVATTSFYVNGDKDKFYPVIFQDNNWGNSVATVIEIGRSDTHYDEWWRGSMIARFRIHNMLWGHGSHFIETDIYQGRHGYAEIVPFIGGYHDATLASGNREFIIWLKGASTYFYVSNAAQSPRIYDNVQNMLPYQQENGAAHTFKTRVEDYVNSRGSNTDGVIHVMGQATNYFAGNIGIGKRDATEKLEVNGNIRAKEIKVETANWPDYVFEEDYKLTPLAEVETFIKANKHLPEVPSAREIEEDGLSLGEMNKLMMKKIEELTLHLIEKEKRHEILSQRVHMLIEKVDQQASEINQLKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK19</accession>
    <name>D7VK19_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11338"/>
    <dbReference type="EnsemblBacteria" id="EFK58621">
        <property type="protein sequence ID" value="EFK58621"/>
        <property type="gene ID" value="HMPREF0766_11338"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080995_1_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032676">
        <property type="entry name" value="YkuD_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38477">
        <property type="entry name" value="PTHR38477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13645">
        <property type="entry name" value="YkuD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107311" evidence="1">
        <location>
            <begin position="21"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="250" mass="28102" checksum="CAFBBCE58FA9EC77" modified="2010-10-05" version="1">MIRFLYIFSLVLFTSSSASVYTGKHIEKKTVVKPIKKVSPVQQLYASMHLEPILKLEAFEQAMRGRSILSTDNRDTMTIIDFTLPSTEKRLYVLDLKNRKVLYHSLVSHGRNSGEKFATSFSNRNNSYQSSLGFYVTEKTYQGGNGYSLVLNGLEEGINDHAKERAVVMHGADYCSEAVIASTGRLGRSYGCPALPRELNAEIINTIKEGTLLYIYADNQNYANKSNILNSESSLLAQRDVENNDKQHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK22</accession>
    <name>D7VK22_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998855.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11341"/>
    <dbReference type="EnsemblBacteria" id="EFK58624">
        <property type="protein sequence ID" value="EFK58624"/>
        <property type="gene ID" value="HMPREF0766_11341"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2791855_0_0_10"/>
    <dbReference type="OrthoDB" id="2097982at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="72" mass="8400" checksum="9304A8C8F1742DA0" modified="2010-10-05" version="1">MAIFAAMDAAELKQYFSSRELPTEIRIAPHMVVTNVPEFLRISFICVDMWEKDVEKCPSWVRLQLLKDAIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK27</accession>
    <name>D7VK27_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase</fullName>
            <ecNumber evidence="2">1.7.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.-.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998869.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11346"/>
    <dbReference type="EnsemblBacteria" id="EFK58629">
        <property type="protein sequence ID" value="EFK58629"/>
        <property type="gene ID" value="HMPREF0766_11346"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055322_1_1_10"/>
    <dbReference type="OrthoDB" id="1818437at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="193" mass="21514" checksum="FB8B74AB349CE420" modified="2010-10-05" version="1">MNILIFNGALERRPSSTSHSIIQFLQQTLEENGIHSTVFNLAGSAIPLFDFTLSKTPVAVEIMTQQFREADAHIWLTPLYHGSMTGVMKNCLDWLEISAKEPRPYLTDKMIGLISWADGGQALQGINAMDAIAKSLRAWPVPFSVPIVKPLLFDEGNPGQITKAYQQKLQLLIRILISKQISARSLQENNVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK52</accession>
    <name>D7VK52_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arylsulfatase</fullName>
            <ecNumber evidence="6">3.1.6.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">aslA</name>
        <name evidence="6" type="ORF">HMPREF0766_11371</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.-" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998932.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11371"/>
    <dbReference type="EnsemblBacteria" id="EFK58654">
        <property type="protein sequence ID" value="EFK58654"/>
        <property type="gene ID" value="HMPREF0766_11371"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_10_4_10"/>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107315" evidence="4">
        <location>
            <begin position="25"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="473" mass="52871" checksum="A34EB97DBC04F656" modified="2010-10-05" version="1">MIHLQKIRLLTAAFLCLSTIGLQAQERKPNIVFILADDLGYGDLGAYGQKQIQTPNIDRLAAEGMKFEQFYAGASVCAPSRSSLMTGQHTGHTYIRGNREIEPEGQQPLADSVQTFVQLLQKAGYATGAFGKWGLGMVGTTGAPDQKGFDEFYGYNCQRQSHRYFPTHLWHNDQRVELHGNDLKNKVQYAPALIQEQTLRFIDVHKDEPFFLFIPTVLPHAELSGIDDEHYQKYASRFQETPHKGNDYGPGATVTGYASVEKPRATFASMVSRMDAYVGQVLKKLDDLGLTENTIVIFSSDNGAHREGGADPVFFNSSGGLRGYKRDLYEGGIRTPFIVKWPHKVKPNSTSEFAGAFWDVMPTLLDITGAGKARYTDGVSLVPALLGKTKEQQQHPYLYWEFHEDGGRQAVRAGDWKAVKLQVKNKQKTVTELYNLKKDPAEKKNVAAENPERVKQLEGIMNQAHTANPYFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK75</accession>
    <name>D7VK75_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11394"/>
    <dbReference type="EnsemblBacteria" id="EFK58677">
        <property type="protein sequence ID" value="EFK58677"/>
        <property type="gene ID" value="HMPREF0766_11394"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50334NK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1712132_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="153" mass="18138" checksum="8CB27820DA443FBF" modified="2010-10-05" version="1">MQAYTYLIQDDNSYKLKSFISFFHIIIVVWWLIGAAIIIYSDHFKTGVSIIILTSLMLAFLFIRLSKTRIFPNERKFKIDTGVRGQAPLLYSFSEIERLEIYVIKWIFGIPIHVTLYVRFRFADKTKRFELTSSLSKKKIQLLYNELEEVLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKI3</accession>
    <name>D7VKI3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999293.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11502"/>
    <dbReference type="EnsemblBacteria" id="EFK58785">
        <property type="protein sequence ID" value="EFK58785"/>
        <property type="gene ID" value="HMPREF0766_11502"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2540859_0_0_10"/>
    <dbReference type="OrthoDB" id="1777515at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="83" mass="9665" checksum="5A45AF013C09D8A9" modified="2010-10-05" version="1">MESQPIRIEQVVAPRTWNIRQRILYPDGSLRDVQIDEDFEGTHFAAYLDNEIIGVISVFRDGELFQFRKFAVLEDYQQKGTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKQ7</accession>
    <name>D7VKQ7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, NAD-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ydgJ</name>
        <name evidence="3" type="ORF">HMPREF0766_11576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999450.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11576"/>
    <dbReference type="EnsemblBacteria" id="EFK58859">
        <property type="protein sequence ID" value="EFK58859"/>
        <property type="gene ID" value="HMPREF0766_11576"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_19_1_10"/>
    <dbReference type="OrthoDB" id="1840839at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="13"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="135"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="340" mass="37973" checksum="25AE7CDD63204AA2" modified="2010-10-05" version="1">MAVKQVVTGILSYGMSGRVFHAPFIGGSESFQLKAIVERKTKQAHLDYPGIISYSSVKELLEDPEIELVIVNTPNDTHFEFAKMALLAGKHVLVEKPFSPTVKEAKELFALGRKMNRHVLPYHNRRFDSDFQSLKATLESGKLGKPVELHLRFDRYKTEIGAKKFKETKRPGSGILYDLGSHLLDQTISLFGKPKSVTKILSNNRPKSKVDDYACLLLNYGKGLSVFITVSLMVANPQKSFVLHALKGSFVKERSDVQEQQLLAGMSPNDIAYGIEPEGKEALLTLADDEGNMQTESLIAERGDYRKLFEAVYQTLRHGAPYFVTEDQILLQLEILAPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKR3</accession>
    <name>D7VKR3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999459.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11582"/>
    <dbReference type="EnsemblBacteria" id="EFK58865">
        <property type="protein sequence ID" value="EFK58865"/>
        <property type="gene ID" value="HMPREF0766_11582"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_12_10_10"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="201" mass="23331" checksum="E56C047546B2FAAC" modified="2010-10-05" version="1">MANADLKRTKILEAATRRFAHFGMAKTTMAEIAKDLSFSKALLYYYFPDKNSLYSAVFEYVMDEMMTEIGDYISKSDNYEDAMMFTLDKRIELINKYYSLFEQSTALVKEMPAEIEKVIKECFEKEATLLGKVLQIGINKGQLEVDDLEDTAKLLLYSLFGMRIGIMKDMKCLIFPTKEEFDFILTLQKKMVKIFLNGLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKY9</accession>
    <name>D7VKY9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11658"/>
    <dbReference type="EnsemblBacteria" id="EFK58262">
        <property type="protein sequence ID" value="EFK58262"/>
        <property type="gene ID" value="HMPREF0766_11658"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3258020_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="42" mass="4959" checksum="9DB93C6E88D62325" modified="2010-10-05" version="1">MMVQMYIIVFFIFYLNGRFIIFLVSQDITPDAEEVGRNSARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL57</accession>
    <name>D7VL57_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inorganic anion transporter, SulP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11726</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999784.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11726"/>
    <dbReference type="EnsemblBacteria" id="EFK58330">
        <property type="protein sequence ID" value="EFK58330"/>
        <property type="gene ID" value="HMPREF0766_11726"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_11_1_10"/>
    <dbReference type="OrthoDB" id="751256at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfate_transp" evidence="6">
        <location>
            <begin position="17"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="511" mass="54785" checksum="0F65D62ABDA73AC7" modified="2010-10-05" version="1">MFGTRMSAFLKLSKRDLKYDFPSSIVVFLVALPLCLGIAMASGAPLFAGILTGIIGGIVVASISKSPLSVSGPAAGLTVIVLGAIQQLGAYETFLLAVVIAGIIQLILGIVKAGMIGNYFPSSVIIGMLAAIGITIILKQIPLAMGLTEKHAFEMDNGGGVAAFADTLLDSINYGALIICLLSLAILIYWPKLPKVNKIPAPLLVVAVGLGLAMAFQGTSFQLSQAQLVTVPVVGSFSEFTGLFTLPDFSQIVNKEVWIVAFTIAIIASLETLLSIEAVDKIDPFKRNTPTNRELIAQGVGNMASGMLGGLPMTSVIVRSSANVNAGGRTRQSAMLHGLWLFIALLAIPTVLNMIPLSCLAAILLHTGYKLAKPALFKEMYVKGWDQFIPFFMTIAVVVFTDLLTGVGVGIVVATFYILKANMKNAFKFDIIKQDDNEKAVITLAEEVTFLNKVPIQQKLYSLPKNIDKIEINGSQSKFIDKDVIEVIKDFQQNAISKGRDIQLTDIVYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLC4</accession>
    <name>D7VLC4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ParB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">spoOJ</name>
        <name evidence="4" type="ORF">HMPREF0766_11793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999994.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11793"/>
    <dbReference type="EnsemblBacteria" id="EFK58397">
        <property type="protein sequence ID" value="EFK58397"/>
        <property type="gene ID" value="HMPREF0766_11793"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023853_0_0_10"/>
    <dbReference type="OrthoDB" id="653368at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="3">
        <location>
            <begin position="47"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="308" mass="34441" checksum="97CE2B7B16DB878E" modified="2010-10-05" version="1">MAAQQRKTGLGKGLGALLQNENIEVSRSSSVSESDVMEKGKTSGSINFIKVDEITVNPFQPRTDFDEQALQELSESIQLQGLIQPITVRQVGDNAYQLISGERRLRASKLAGITSIPAYVRTANDQQMLEMALIENIQRENLNAIEVALSFQRMIEECNLKQEELGDRVSKNRSTVTNYLRLLKLPPVIQAAIRDGQLSMGHARALINVGEVDKQLYIFKEIIEKGLSVRKAEQLVREVQQAVARKKAPSDKKTALTFQFQKIEDDLASKFASRVKLNVKSSTKGKGAIEIPFESEDDLSRILELLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLG9</accession>
    <name>D7VLG9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Octanoyltransferase</fullName>
            <ecNumber evidence="6 7">2.3.1.181</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lipoate-protein ligase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoyl/octanoyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">lipB</name>
        <name evidence="12" type="ORF">HMPREF0766_11839</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6 7">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the LipB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="6 7"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000117.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11839"/>
    <dbReference type="EnsemblBacteria" id="EFK58442">
        <property type="protein sequence ID" value="EFK58442"/>
        <property type="gene ID" value="HMPREF0766_11839"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035168_1_3_10"/>
    <dbReference type="OrthoDB" id="1806796at2"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="11">
        <location>
            <begin position="43"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="88"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="173"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6 8">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="6 10">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK58442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="231" mass="26548" checksum="82740041DA48F730" modified="2010-10-05" version="1">MNKKVQFADWGLQDYQDAWNRQEEIFKSILDIKHDNRVNEAHTETSNYLIFTEHPHVYTLGKSGHPDNLLLDEQGLEEKQATFYKINRGGDITYHGPGQIVGYPILDLDNFFTDIHLYLRTLEEAIILTLADYGIPAGRYPGYTGVWIDPDNDKARKICAMGVRASRWVTMHGFAFNVNADLSYFGNIVPCGIDDKDVTSMQRELGREVDINEVKDRLKNHLADLFHMELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLI6</accession>
    <name>D7VLI6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000157.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11856"/>
    <dbReference type="EnsemblBacteria" id="EFK58459">
        <property type="protein sequence ID" value="EFK58459"/>
        <property type="gene ID" value="HMPREF0766_11856"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031MC1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_499568_0_0_10"/>
    <dbReference type="OrthoDB" id="1847323at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="540" mass="58931" checksum="9B070AC6FD38E5B2" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLL5</accession>
    <name>D7VLL5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000213.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11885"/>
    <dbReference type="EnsemblBacteria" id="EFK58488">
        <property type="protein sequence ID" value="EFK58488"/>
        <property type="gene ID" value="HMPREF0766_11885"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032900_1_0_10"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107389" evidence="2">
        <location>
            <begin position="22"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="529"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="572" mass="63579" checksum="C646B82F451FD99B" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLR8</accession>
    <name>D7VLR8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase, class I/II</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bioF2</name>
        <name evidence="2" type="ORF">HMPREF0766_11938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000007">
        <property type="protein sequence ID" value="EFK58220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11938"/>
    <dbReference type="EnsemblBacteria" id="EFK58220">
        <property type="protein sequence ID" value="EFK58220"/>
        <property type="gene ID" value="HMPREF0766_11938"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_11_2_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="31"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="370" mass="41192" checksum="31FB065A8CAF2832" modified="2010-10-05" version="1">MMNSLSERLSDKLKLRAGKGNLRSLKIPEQGIDFFSNDYLGLARNSVIHKQLAKEIYADSSILGGATGSRLISGNSYEKMQAEQEIAALHGHAAGLLFASGYLANMALLSALPGRGDTIIMDERIHRSVHDGATLSAAQKWKFRHNDLNSLEDKLRRAGGQIYVVVESLYSMDGDFAPLNELVVLARRYKAALIIDEAHAFGVFGYGLVHQYGLQKHIFATVITYGKALGAHGAVVLGEELLKSYLINFASPFIYSTACPDLFARHIRLGYTFLREHSELSDQLRRRIAYFGQRKIPSVSDPKSPIQAVIIPQHKVLIHLQQQLQKKGLQTYAVHSPAVEEGQERLRICLHQYNTEEEIDLLTAEINSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLS3</accession>
    <name>D7VLS3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0766_11943</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000007">
        <property type="protein sequence ID" value="EFK58225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000970.1">
        <property type="nucleotide sequence ID" value="NZ_GL379775.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11943"/>
    <dbReference type="EnsemblBacteria" id="EFK58225">
        <property type="protein sequence ID" value="EFK58225"/>
        <property type="gene ID" value="HMPREF0766_11943"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_10"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="178"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="239"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK58225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="458" mass="52135" checksum="1EAF3F0AFAF81ED0" modified="2010-10-05" version="1">MGARARLTLLFTLITATILLIFGAVLYFSAKQNRQKEFYALLKKEAVTKANLFFTAGVDVRTLQSIYHNNRKIINEVEVAIYTHDFQLLYHDAVDIDVVKENLSMIDQIYNKGEVQFYLNDWQVIGIRHVYKGKTYIITAAAYDQYGYNKLANMLWVSILVFVVSILFIYVAGRFFSQRAFAPVREMTERARQISTTSLHMRLDTGHAKDELTELAETFNDLLNRLENSFDAQKQFVSNVAHELRTPLAAITAELELSTSRERSIVEYQEVIRNTLNDAKKLGRLSNSLLDFAKATYDPVDISFKSVRVDEILLDAQLQVQKVDKDYKISINFENDFEHDKQISVNGNSYLLMVAFANLFENGCKFSDDKQCRLTVSFTATSITLRFSDEGIGISEEDLQHIFTPFFRGQNKMFAEGNGIGLPLTRKIISLHKGDITVVSSTETGTTFTVTLPVLMNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM86</accession>
    <name>D7VM86_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinate dehydrogenase cytochrome B subunit, b558 family</fullName>
            <ecNumber evidence="2">1.3.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sdhC</name>
        <name evidence="2" type="ORF">HMPREF0766_12083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001368.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12083"/>
    <dbReference type="EnsemblBacteria" id="EFK58091">
        <property type="protein sequence ID" value="EFK58091"/>
        <property type="gene ID" value="HMPREF0766_12083"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7U4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077968_1_0_10"/>
    <dbReference type="OrthoDB" id="750409at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011138">
        <property type="entry name" value="Cytochrome_b-558"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02046">
        <property type="entry name" value="sdhC_b558_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="218" mass="25304" checksum="7E2232FC5A0D518A" modified="2010-10-05" version="1">MLSTLSKKIVMCLTGLFLCFFLIIHFLGNLQLFLPAEQAREQFNWYSHFLSGNALIKIVSYVLYASILLHMLDALVITIRNRKSGGSYRQDKRGRASKWYSRNMGILGTIILIFLVIHFQNFWYVYKFGTLPLDGNGHKDLYLLVVTTFKEWWYVLIYVLAMIALCYHLIHGVYSSIRTLGLFHPKYIKWLKIAGIAYSVIICAGFALMPVYVYFTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMC3</accession>
    <name>D7VMC3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribulokinase/uridine kinase family protein</fullName>
            <ecNumber evidence="2">2.7.1.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">udk</name>
        <name evidence="2" type="ORF">HMPREF0766_12120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001442.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12120"/>
    <dbReference type="EnsemblBacteria" id="EFK58128">
        <property type="protein sequence ID" value="EFK58128"/>
        <property type="gene ID" value="HMPREF0766_12120"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021278_1_2_10"/>
    <dbReference type="OrthoDB" id="1793376at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRK" evidence="1">
        <location>
            <begin position="7"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="212" mass="24928" checksum="D3D854808E5C8BEB" modified="2010-10-05" version="1">MNNKPFVIGIAGSSGSGKTFFLNSFLQHFSKDEITLISQDDYYIPANTKTQEENRLYNFDIPTSIDRSAFYNDIKDLFDGKTVFKEEYTFNNPALTPKMLEIKPAPILIIEGLFIFYYTEVNDLLDMRIFLDAEESVALERRLRRDLIERGYDEDDVRYKWVNHVVPSYNEYLLPYREFCDKVIINNIDDPEPIRMVTDEICQEVKDKIKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VME9</accession>
    <name>D7VME9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NOL1/NOP2/sun family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rrm</name>
        <name evidence="6" type="ORF">HMPREF0766_12146</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12146"/>
    <dbReference type="EnsemblBacteria" id="EFK58154">
        <property type="protein sequence ID" value="EFK58154"/>
        <property type="gene ID" value="HMPREF0766_12146"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0144">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_713402_0_0_10"/>
    <dbReference type="OrthoDB" id="1064993at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="5">
        <location>
            <begin position="125"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="392" mass="44704" checksum="746C291B7C28502E" modified="2010-10-05" version="1">MLMEVNERRIGQQIRNFERALSSYPNKEPFSRFLTQFFKDNKQMGSSDRRMTSRLCYNFFRLGTAAAQLPVTNRVVLAEFLCETESTVVSYYQPEWTPRLGDPVSDKIDFLVSLDLINKSDLFPFQQHLSAPIDTELFLQSQLIQPDLFIRLKRGSEAKVKHILTEAGVAFENVRSQTLALRNGTNLQQLKGLSGLYEVQDLSSQKTIDLIEAKDGESWWDACAASGGKALLFLDKYPSVKLLVSDIRMSILRNLDERFDLAGIKNYRKKVIDLTRDPLTILDKELFDGIILDAPCSGSGTWGRTPEMISQFRESAIASFSVLQRQIAKNVLRHLKPGKTLLYITCSVFKEENEDVVNFICEHLGCELEEMVTLKGYEQQADTMFAARLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMF4</accession>
    <name>D7VMF4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pseudouridine synthase, RluA family</fullName>
            <ecNumber evidence="2">5.4.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rluA2</name>
        <name evidence="2" type="ORF">HMPREF0766_12151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001494.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12151"/>
    <dbReference type="EnsemblBacteria" id="EFK58159">
        <property type="protein sequence ID" value="EFK58159"/>
        <property type="gene ID" value="HMPREF0766_12151"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_11_3_10"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="24"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="247" mass="28830" checksum="99ED09891236FCF7" modified="2010-10-05" version="1">MKQSEAKLFKFPKFTDLIIHEDENIIVINKPPFIASLDEREGGEINILRLAKKYYADAQICHRLDKETSGILLIAKNPETYRLISIEFEKRRVDKTYHAIIEGTHIFQDLKIDLPILNQGNKNVTIDRYNGKPAETIFNSIQYFKHFTLVECKPITGRMHQIRIHLATQHAAIVGDSMYRGKPVYLSQIKKRGFTLSKDEEEQPIMKRFALHSKKVRFKVADKSYEFEAEYPKDFAILLKQLEKFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMM3</accession>
    <name>D7VMM3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992686.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12243"/>
    <dbReference type="EnsemblBacteria" id="EFK57170">
        <property type="protein sequence ID" value="EFK57170"/>
        <property type="gene ID" value="HMPREF0766_12243"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZBUH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120969_0_0_10"/>
    <dbReference type="OrthoDB" id="1684440at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="178" mass="20800" checksum="A4C5942F5F482DF7" modified="2010-10-05" version="1">MDYIEFFKNLFLIAFGVCAGLILAFRLVWPKVEALIIKTKMLDKKMSGQKGSTGGEREQLKAGAYERLLLFTSRIEPRNLIARHLEDNQHVRTLHLRLIQEVENEFQYNFTQQLYVSADAWEAVRLLKENTVILLNNAMKDHTDTQEVYAEEVLKFLSNLRPDPYQTTQLIIRQEANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMR2</accession>
    <name>D7VMR2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase, M28 family</fullName>
            <ecNumber evidence="3">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992752.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12282"/>
    <dbReference type="EnsemblBacteria" id="EFK57209">
        <property type="protein sequence ID" value="EFK57209"/>
        <property type="gene ID" value="HMPREF0766_12282"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019932_2_0_10"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107714" evidence="1">
        <location>
            <begin position="21"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="2">
        <location>
            <begin position="291"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="522" mass="58858" checksum="95D73BE3FBA83578" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMR6</accession>
    <name>D7VMR6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Biotin carboxyl carrier protein of acetyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">accB</name>
        <name evidence="4" type="ORF">HMPREF0766_12286</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992757.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12286"/>
    <dbReference type="EnsemblBacteria" id="EFK57213">
        <property type="protein sequence ID" value="EFK57213"/>
        <property type="gene ID" value="HMPREF0766_12286"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_3_0_10"/>
    <dbReference type="OrthoDB" id="1938042at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001249">
        <property type="entry name" value="AcCoA_biotinCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01071">
        <property type="entry name" value="ACOABIOTINCC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00531">
        <property type="entry name" value="BCCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="3">
        <location>
            <begin position="80"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="158" mass="16727" checksum="7540F895392210CC" modified="2010-10-05" version="1">MSMDIKQIQDLIKFVAKSGVNEVAIEEKDFKITIKTNQEPTIVTATVPTAAPVATALPAAPVATAPAAPVAVAADNNANYITVKSPMIGTFYRAAGPGKPNFVNVGDEITAGKVLCIVEAMKLFNEIESEVSGKIVKILIDDAKPVEYDQPLFLVDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN26</accession>
    <name>D7VN26_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992926.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12396"/>
    <dbReference type="EnsemblBacteria" id="EFK57323">
        <property type="protein sequence ID" value="EFK57323"/>
        <property type="gene ID" value="HMPREF0766_12396"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1093743_0_0_10"/>
    <dbReference type="OrthoDB" id="1048366at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043991">
        <property type="entry name" value="Gp3-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18897">
        <property type="entry name" value="Gp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="254" mass="27762" checksum="247D3C5FEC9686A1" modified="2010-10-05" version="1">MKGRISTGTVQGSTLPEIGRIKVGMKTERGLPTSLDYFRATGKFATHFASLVGDKPTELHIAFVSNNLSEVCNEQFEAWDKGKRLGWGDGSTFTVWNPSGGKDNKGAYESDLAPTDPKVGAIRKFFARTLTLRFVLLKMKGVLGYWTFQTKAKETTIPSIVKAFDMVMERSGSIIGFPFSLVVEKVQSYTPGMAKNYPIVKLIPNFTEETIEQVRAYVESGGELNRLTTNMITSGSLLQLGSGSGVAVAVEEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN88</accession>
    <name>D7VN88_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12458"/>
    <dbReference type="EnsemblBacteria" id="EFK57385">
        <property type="protein sequence ID" value="EFK57385"/>
        <property type="gene ID" value="HMPREF0766_12458"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2810241_0_0_10"/>
    <dbReference type="OrthoDB" id="2187720at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="67" mass="7791" checksum="61EB92527F8A1F73" modified="2010-10-05" version="1">MKHKYPLKTRAFAMELLHKSNTIVEVSHKIGCGIRTVSRWYMDYLGYRGKEGIIEVKQSKLNSPRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNB1</accession>
    <name>D7VNB1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993037.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12481"/>
    <dbReference type="EnsemblBacteria" id="EFK57408">
        <property type="protein sequence ID" value="EFK57408"/>
        <property type="gene ID" value="HMPREF0766_12481"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199837_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025842">
        <property type="entry name" value="Bacteroid_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026437">
        <property type="entry name" value="CxxCx5CxxC_targ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14406">
        <property type="entry name" value="Bacteroid_pep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04139">
        <property type="entry name" value="CxxCx5CxxC_targ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="75" mass="8422" checksum="E409542992815AE2" modified="2010-10-05" version="1">MKKLTGMKDFSALEEKKVDLNVIGGLAMSMSQGFYEIQSNFVDAHGCRDVDVYDGNGGAYLSRLWIKDGRFPHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNE3</accession>
    <name>D7VNE3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <shortName evidence="8">PCK</shortName>
            <shortName evidence="8">PEP carboxykinase</shortName>
            <shortName evidence="8">PEPCK</shortName>
            <ecNumber evidence="4 8">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">pckA</name>
        <name evidence="9" type="ORF">HMPREF0766_12513</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="4 8"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993080.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12513"/>
    <dbReference type="EnsemblBacteria" id="EFK57440">
        <property type="protein sequence ID" value="EFK57440"/>
        <property type="gene ID" value="HMPREF0766_12513"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018247_0_1_10"/>
    <dbReference type="OrthoDB" id="146648at2"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PTHR30031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="237"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="443"/>
            <end position="444"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK57440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="538" mass="59448" checksum="E4CF95E0DD7E85FA" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNG0</accession>
    <name>D7VNG0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="21">1.1.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">thrA</name>
        <name evidence="21" type="ORF">HMPREF0766_12530</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the N-terminal section; belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="21"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993098.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12530"/>
    <dbReference type="EnsemblBacteria" id="EFK57457">
        <property type="protein sequence ID" value="EFK57457"/>
        <property type="gene ID" value="HMPREF0766_12530"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0460">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0527">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_7_1_10"/>
    <dbReference type="OrthoDB" id="1067792at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042199">
        <property type="entry name" value="AsparK_Bifunc_asparK/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_aspartokin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070">
        <property type="entry name" value="PTHR43070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000727">
        <property type="entry name" value="ThrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="17" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="20">
        <location>
            <begin position="400"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00007952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00010046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EFK57457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="815" mass="89196" checksum="A76510205B180B65" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNJ5</accession>
    <name>D7VNJ5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993146.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12565"/>
    <dbReference type="EnsemblBacteria" id="EFK57492">
        <property type="protein sequence ID" value="EFK57492"/>
        <property type="gene ID" value="HMPREF0766_12565"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2685963_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="74" mass="8741" checksum="8B6DD07EF5FF0272" modified="2010-10-05" version="1">METTDRITKETDLEKFCRERFKHLTNAQLVARVNGLPDFGWDDEGVELRRRHRVSNGAFDYAFNHNTMVILKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNT8</accession>
    <name>D7VNT8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993282.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12658"/>
    <dbReference type="EnsemblBacteria" id="EFK57585">
        <property type="protein sequence ID" value="EFK57585"/>
        <property type="gene ID" value="HMPREF0766_12658"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2248404_0_0_10"/>
    <dbReference type="OrthoDB" id="2083680at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107393" evidence="1">
        <location>
            <begin position="34"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="104" mass="11186" checksum="6DBFC7C3AF348122" modified="2010-10-05" version="1">MMKKIKNNLFALAAVTIASVTMSFSVMKNASLAGEKWFAYTDETGDGNISNPENFALVNENGSTAPPCITGNDILCAIKAKPLIGDTEHPDMNTVISSIYTRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP02</accession>
    <name>D7VP02_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993394.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12722"/>
    <dbReference type="EnsemblBacteria" id="EFK57649">
        <property type="protein sequence ID" value="EFK57649"/>
        <property type="gene ID" value="HMPREF0766_12722"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5562">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139663_0_0_10"/>
    <dbReference type="OrthoDB" id="1984942at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009833">
        <property type="entry name" value="DUF1398"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036696">
        <property type="entry name" value="YdfO-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07166">
        <property type="entry name" value="DUF1398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160419">
        <property type="entry name" value="SSF160419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="129" mass="14750" checksum="7E897855FD44EDE7" modified="2010-10-05" version="1">MFTIEQIRQAHAKVKSGADFPAYMREIKALGVLGYDAYVADGRIDYFGAEGYTTSAPARYDRLEIAGQSDIMQFRKDLKDHQQGLTDYLTFCRDCARSGVEKWIIDMDRMTCAYYDKVGNELLIENIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP61</accession>
    <name>D7VP61_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Energy-dependent translational throttle protein EttA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Translational regulatory factor EttA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ettA</name>
        <name evidence="10" type="ORF">HMPREF0766_12781</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">Associates with ribosomes and polysomes.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993485.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12781"/>
    <dbReference type="EnsemblBacteria" id="EFK57708">
        <property type="protein sequence ID" value="EFK57708"/>
        <property type="gene ID" value="HMPREF0766_12781"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_10"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00847">
        <property type="entry name" value="EttA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022374">
        <property type="entry name" value="EttA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43858">
        <property type="entry name" value="PTHR43858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03719">
        <property type="entry name" value="ABC_ABC_ChvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="8"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="331"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="PtIM" evidence="7">
        <location>
            <begin position="249"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="363"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK57708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="560" mass="63120" checksum="52A7682BE5ACD2EA" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPB0</accession>
    <name>D7VPB0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, NUDIX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993588.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12830"/>
    <dbReference type="EnsemblBacteria" id="EFK57757">
        <property type="protein sequence ID" value="EFK57757"/>
        <property type="gene ID" value="HMPREF0766_12830"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_18_3_10"/>
    <dbReference type="OrthoDB" id="1846332at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="150" mass="17393" checksum="A9A93D0813EB476C" modified="2010-10-05" version="1">MYPFNVRVYGILINEHDEVLISDEKTESVSFTKFPGGGLEYGEGLIDALKREYEEECGLSVDVVKHIYTTDFWEKSSFNDSQIISIYYLVKANQPLNVSIKEKVFDFDKDEAGEKLQAFRLVPVNQVKLSELTFKTDQVAWQEYLKSRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPB8</accession>
    <name>D7VPB8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prephenate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pheA</name>
        <name evidence="10" type="ORF">HMPREF0766_12838</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993603.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12838"/>
    <dbReference type="EnsemblBacteria" id="EFK57765">
        <property type="protein sequence ID" value="EFK57765"/>
        <property type="gene ID" value="HMPREF0766_12838"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035008_1_0_10"/>
    <dbReference type="OrthoDB" id="1280729at2"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="193"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK57765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="274" mass="30889" checksum="5CF2F81A10FA8B61" modified="2010-10-05" version="1">MSLKIAIQGAKASFHEEAAFKYFGNDIEIVECDSFKKTCDILKQKKADYVVMAIENSIAGSILQNYNLLRDYRFHIVGEVYLHIQQHLLAMPGVKLADIKIVESHPIAIRQCDAFLEDHPHFLVKEFTDTAAAAKKIADEKLTSTAAIAGELAAKLYGLEIIERRIETNKKNATRFLILADEVVEQKNANKASLSFQTGNAVGALANVLQCFAEQNVNLTKIQSMPVVGRRNDYDFYVDVEWKKQSEYDAAIRKVLKHTVNFSIMGEYIKNEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPC4</accession>
    <name>D7VPC4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Penicillin-binding protein 2</fullName>
            <ecNumber evidence="6">2.4.1.129</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mrdA</name>
        <name evidence="6" type="ORF">HMPREF0766_12844</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993611.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12844"/>
    <dbReference type="EnsemblBacteria" id="EFK57771">
        <property type="protein sequence ID" value="EFK57771"/>
        <property type="gene ID" value="HMPREF0766_12844"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_1_2_10"/>
    <dbReference type="OrthoDB" id="423699at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017790">
        <property type="entry name" value="Penicillin-binding_protein_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03423">
        <property type="entry name" value="pbp2_mrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="5">
        <location>
            <begin position="51"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="4">
        <location>
            <begin position="253"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="611"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="611"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK57771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="656" mass="73246" checksum="9E8C74BAF80D926A" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPI4</accession>
    <name>D7VPI4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative cystathionine beta-synthase</fullName>
            <ecNumber evidence="6">2.5.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cysK</name>
        <name evidence="6" type="ORF">HMPREF0766_12904</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993733.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12904"/>
    <dbReference type="EnsemblBacteria" id="EFK57831">
        <property type="protein sequence ID" value="EFK57831"/>
        <property type="gene ID" value="HMPREF0766_12904"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_0_0_10"/>
    <dbReference type="OrthoDB" id="1677960at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="339"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK57831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="454" mass="49974" checksum="F01C9D181EA4C517" modified="2010-10-05" version="1">MWYNNILETIGNTPLVKLNKVTKHLKGTILAKIETTNPGNSIKDRMAIKMIEDAEKAGLLKPGGTIIEGTSGNTGMGLAMAAVVKGYRCIFTTTDKQSKEKIDALRAFGAEVIVCPTNVEPEDPRSYYSVSSRLEKEVPNAWKANQYDNPSNAQAHYETTGPEIWKQTEGKITHLIVGVGTGGTISGTARYLREKNPDIKVWGIDTYGSVFKKYKETGIFDKNEIYPYITEGIGEDFLPENVDFSVIDLFEKVTDKDAALLTRDLARKEGIFAGNSAGAAVAGLLQLGASLKEEDVVVVIFHDHGSRYMGKMYNEDWLRERGFLKDEKLTALTILKKRETQDIVTADVDQTVIETFNTMKTLNISQIPVTQQGMVVGKITESDILSALLENPSTKSAKVQSISTKPFPFVDLNASIDKISALINKDSQAVLVEDEYGRINIITQYDIINAISGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPN6</accession>
    <name>D7VPN6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993817.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12956"/>
    <dbReference type="EnsemblBacteria" id="EFK57883">
        <property type="protein sequence ID" value="EFK57883"/>
        <property type="gene ID" value="HMPREF0766_12956"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154418_0_0_10"/>
    <dbReference type="OrthoDB" id="2013925at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019206">
        <property type="entry name" value="DUF2085_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09858">
        <property type="entry name" value="DUF2085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="119" mass="13367" checksum="7715F00321BA4D05" modified="2010-10-05" version="1">MKTKLEFTFCHRKPERSFFWKGKQFPVCARCTGIHLGYMSTFLFVFGVISMNFWVAVLCMLPTIIDGLTQAYCNRESNNTLRFITGIMAGVGTMAVCAIIGRAIGALILEGIKLIIKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPY3</accession>
    <name>D7VPY3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993945.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13037"/>
    <dbReference type="EnsemblBacteria" id="EFK55834">
        <property type="protein sequence ID" value="EFK55834"/>
        <property type="gene ID" value="HMPREF0766_13037"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_767043_0_0_10"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="252"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK55834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="361" mass="42661" checksum="80B4FF47DB7E64C3" modified="2010-10-05" version="1">MTATILFTAILLMTGVTLGFILFTKSTAFIDQVTQSILVIFVFYTLFTVVCSYIYPSLSYLDKASPLWWIFGPCGYIRFKATERTRWSVQDIWHLIPLMLMLPFYFLFISSVSIRNDYGYIYYSVLYTCTACIWFGYALFIIFSLGRKTETPIDSNGYLDYISVILLFILAFFMMSVAYNYIVYKQDAVSSLSGLLLFFAMFIGVSAAYLHYFYLLMQRKRQSETADHIRQPGQGKMHNRYPDEGDRKLWVQRIDEYLVPERYLDMRFNMLKMSKNLKIPKEQLLLIFEQHYRKSFITYINQLRVNYACKMLADQDFNLSMEQLAADCGFRSKASFYRCFREEHSCTPLMFRERQIKNQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ08</accession>
    <name>D7VQ08_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993979.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13062"/>
    <dbReference type="EnsemblBacteria" id="EFK55859">
        <property type="protein sequence ID" value="EFK55859"/>
        <property type="gene ID" value="HMPREF0766_13062"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057487_0_0_10"/>
    <dbReference type="OrthoDB" id="1581250at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018550">
        <property type="entry name" value="Lipid-A_deacylase-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09411">
        <property type="entry name" value="PagL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="372" mass="42221" checksum="D55947272E4E1FC9" modified="2010-10-05" version="1">MHGMCEAQSSLLWTTQDSIAPARRKNPLIIEIEAENGGIIASKDIKQVTFEDAYYNGVNLRVGWQTQRSKDIYHQLYNYPIYGVGLYSSTFNTNIIGSPYALYGFVIVPIHPKNDKRWTYEYRIALGLSGNFKPYNEETNPLNLVIGTKNNVFIDFGFRAKYKFHKNFDVGVGAAFHHFSNGAMRLPNKGVNLLPLTASLTYTPNSESADYSRAEVPPFEQTWLYHINLAGGFKQIDRQIDKRYHKATLSAYMSRHVSYKWRFGGGFDFFYSASGNAEEIAGSEKGKFSALFSGGPAFYMAHVLNERLVLNGNIGYYLHKNNFNGEIENFYVRAGARYYVYKNINAGVSIKAHMGKADYIEWTAGYTFGKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQA5</accession>
    <name>D7VQA5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_13159</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13159"/>
    <dbReference type="EnsemblBacteria" id="EFK55956">
        <property type="protein sequence ID" value="EFK55956"/>
        <property type="gene ID" value="HMPREF0766_13159"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_18_5_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="91"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="261"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK55956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="668" mass="75574" checksum="A0D78A09CBBA34BE" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQF2</accession>
    <name>D7VQF2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminopyrimidine aminohydrolase</fullName>
            <ecNumber evidence="1">3.5.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tenA</name>
        <name evidence="3" type="ORF">HMPREF0766_13206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-5-aminomethyl-2-methylpyrimidine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:31799"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:63416"/>
            <dbReference type="EC" id="3.5.99.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17509"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="EC" id="3.5.99.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TenA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.2" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994249.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13206"/>
    <dbReference type="EnsemblBacteria" id="EFK56003">
        <property type="protein sequence ID" value="EFK56003"/>
        <property type="gene ID" value="HMPREF0766_13206"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0819">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077537_3_2_10"/>
    <dbReference type="OrthoDB" id="1537025at2"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050334">
        <property type="term" value="F:thiaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027574">
        <property type="entry name" value="Thiaminase_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04306">
        <property type="entry name" value="salvage_TenA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0784">Thiamine biosynthesis</keyword>
    <feature type="domain" description="TENA_THI-4" evidence="2">
        <location>
            <begin position="8"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="215" mass="24812" checksum="4FD9ADF1EA54766F" modified="2010-10-05" version="1">MNWSEQAWKTIQPVYTNILQMPFITELRNGTLAAEKFQFYMAQDSAYLEHFGRALSLIGARADHIQDALAFMRFGANAIIVENALHESYFKDFGVTERGQIQPACHHYIHFLKSTAALDAVEVGIAALLPCFWIYKQVGDYIYTHQQQENNPYQKWIDTYAGEEFGEEVRKAIAICDRVAAKATTDTRLKMTEAFVTASRLEYDFWDAAYQLRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQG3</accession>
    <name>D7VQG3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994271.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13217"/>
    <dbReference type="EnsemblBacteria" id="EFK56014">
        <property type="protein sequence ID" value="EFK56014"/>
        <property type="gene ID" value="HMPREF0766_13217"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2525846_0_0_10"/>
    <dbReference type="OrthoDB" id="1639867at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="84" mass="9212" checksum="BD1510FFB9E4E1A8" modified="2010-10-05" version="1">MLSFVYDESGNRIRKQDHRTGSVTYYSYDAGGSLMAIYDNAGSGGAIRLAEQPVYAANRIGTYYRQAGRQAGRQLSVHTDRSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQR5</accession>
    <name>D7VQR5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, NAD-binding domain protein</fullName>
            <ecNumber evidence="3">1.1.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yisS</name>
        <name evidence="3" type="ORF">HMPREF0766_13319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.18" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994443.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13319"/>
    <dbReference type="EnsemblBacteria" id="EFK56116">
        <property type="protein sequence ID" value="EFK56116"/>
        <property type="gene ID" value="HMPREF0766_13319"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_17_1_10"/>
    <dbReference type="OrthoDB" id="1339160at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050112">
        <property type="term" value="F:inositol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="150"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="383" mass="42329" checksum="B1281CEFCE1A8056" modified="2010-10-05" version="1">MNSTKIRMGMIGGGKNAFIGAVHRMAAGMDGHIELCCGALSADPHMARESGELLYLPQDRIYTGYQEMIAQESQLPADKRIHFVSIVTPNFAHFEPAMMALDHGFHVVLEKPMTLTLEEARQLQLKVAETGLLLCLTHTYSAYPMVKQARQLVKENKLGQIRKIMVEYPQGWLSTMIETDVALAAWRTDPQKSGKSGCMGDIGTHAAHLAEYISGLKIQKICADLQTFVQGRRLEDDGNILLRFDNGASGVLSASQVAAGEENALKIRIYGEKAGLEWNQQEPNTLLLKWLDAPAQIFRTGQSYLHPVTKHNTRLPAGHPEGYIEAFANIYNNFAHTILASVNGTKASEDQLDFPTAEDGVRGMKFIETVIASAQSDLKWTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQT9</accession>
    <name>D7VQT9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994472.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13343"/>
    <dbReference type="EnsemblBacteria" id="EFK56140">
        <property type="protein sequence ID" value="EFK56140"/>
        <property type="gene ID" value="HMPREF0766_13343"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_2_10"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="189"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="289" mass="33551" checksum="08E7D8EB34DD5D6B" modified="2010-10-05" version="1">MDKQMDNIPVYDISMFNADCTLFWMETLERCSVRNLWLRRPHKQRFCMLLYLTKASGVVRIDDTIIQSDHNETVICSTPNSVNSIKLEPDSTGFIIAFTEDFFSLRFNSNILYQFSFFKENGNCFFGLSKQDESKWNSLSGLMLQEFSGGKGDIKVLRSYLNILLHEIEGHTNVHIPSLADGHAHDKVMKFQKLLERNFIQHKSPSYYADKLNITLHYLNKLCKICRGMTSGQIIKERILTESKRLLKHTTLSIAEIGYELGFESPSYFITFFKKNIGYTPESYRRSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQW3</accession>
    <name>D7VQW3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994503.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13367"/>
    <dbReference type="EnsemblBacteria" id="EFK56164">
        <property type="protein sequence ID" value="EFK56164"/>
        <property type="gene ID" value="HMPREF0766_13367"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122336_1_1_10"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="163" mass="18962" checksum="7B95F605B2D57526" modified="2010-10-05" version="1">MNIIDSLGILALSTRLQRLSEQLRKEGALLYKEFDIDFEPKWFPVMYTLFHKGTLSVVEIASEIGYTHPSTINLLKELENQKLIRSKKDKIDERKRLLQLTAKGTDLITKMEPVWDIMITVLTEITNNQNNLLQAIQETEQRIAEQSFMQRAMVLKNKKNIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQW6</accession>
    <name>D7VQW6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glucose/galactose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994507.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13370"/>
    <dbReference type="EnsemblBacteria" id="EFK56167">
        <property type="protein sequence ID" value="EFK56167"/>
        <property type="gene ID" value="HMPREF0766_13370"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028452_2_2_10"/>
    <dbReference type="OrthoDB" id="1121832at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="439" mass="48081" checksum="CEA0485A37CC24E5" modified="2010-10-05" version="1">METKLRNGILPFAIVTFIYFIVGFLTTVNEQLQAPLKFTFLAEAGSLKNTFTTLISFFFFLGYLLNGTLASKWVNAAGYKNTLLRGLLFMISGLLMYLCSSWFGYQYPHLALHFADAALPYGFIIFIIGSYLMGTSAAVIQVVVNPYVASYELPGTQAVQRLNITTAINSIGTTSAPFFVTVVMFSGISIANIEIRQLLMPLLALIACVIVVTLITRQLHLPDIANTRAASGEKLERSIWSFRHFALGVMAIFFYVGTEVAIGANINLHAFELMESGHPMSFFGKTDIIIGGVDLGIHALLSTLYWGGFLVGRAISSFFSKISAKTQLTVTTISATILAIIAMITQNLWFLVAIGLLHSTMWSCIFSLSIKGLNKYTSKASGVFISAVFGGAVFTLVQGGLADILGSWRWTWSLTVICELLMLSYALFGSRIRPKDIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR04</accession>
    <name>D7VR04_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rprX</name>
        <name evidence="4" type="ORF">HMPREF0766_13408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994558.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13408"/>
    <dbReference type="EnsemblBacteria" id="EFK56205">
        <property type="protein sequence ID" value="EFK56205"/>
        <property type="gene ID" value="HMPREF0766_13408"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026375_0_0_10"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="259"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="481" mass="55519" checksum="E9F1D926AABA79E8" modified="2010-10-05" version="1">MEKRKFKVIIYLLAISTVAMLILQSYWLYSDFKLNREKNQANIRRVVLESLDQYSLISMSKLYKIEKKDSIAARQLAKTIQSLTQIYSDDSIQTKKGKKTVTFNINTTIDTLEKSSSDTLQASSKVSVHKPEIMHKERLVVTEKAISEVIKKHFQANQITNPYQLSLKSVQQPRIWYTKDTLLFQKYNFIAVQGKAIDLNVIATVHVEDDMLGPLKSIFWTLLISLLIVLFIMYGLIYLIKQLREEKRMSEIKNDFISNMTHEFKTPISTVSLAIQSIRYFGIKDDPEKLDEYLGICLNELHRTSSMIERVLKLSHEKPFVIKLEEFSLSELLTTFHNQSKPVLTEFNGILDIQNDSTVDLITADKVHFGNLLFNLLDNSIKYRKAEENPHILIRLYNDDKNLYMIFRDNGIGISKVYLNKIFENFFRVPTGNVHNAQGFGLGLSYVQKIIHLHNGSIKVHSEVSKGTTFTIEIPLIPNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR19</accession>
    <name>D7VR19_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Siderophore-interacting FAD-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994579.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13423"/>
    <dbReference type="EnsemblBacteria" id="EFK56220">
        <property type="protein sequence ID" value="EFK56220"/>
        <property type="gene ID" value="HMPREF0766_13423"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2375">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040923_3_1_10"/>
    <dbReference type="OrthoDB" id="1630289at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="270" mass="29968" checksum="3C701884898E6BC2" modified="2010-10-05" version="1">MEQTAIARHVFHVSKKEFITPHYIRVTLQGDGARDFAACTIGANNKIFIPPAGSKEVAFPVFDAEKGAWVNPADNEKPIVRTYTHRGIDVANKEILIDFVNHGDNGPASSWALHAKEGDALGVAMKLRKNPLYPAADWYFLIGDATAIPVLASILESLPPEAKGHCILEVSSPTDIQPQLGHAGFTIQWIFNGHPESGSSLAEEVLKVSIPNEGTHFAYIACEYSSVRTLRSYFREKLQWSNQELYAFSYWKAGVAEDQSAQDRRQEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR35</accession>
    <name>D7VR35_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor</fullName>
            <ecNumber evidence="4">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpoE2</name>
        <name evidence="4" type="ORF">HMPREF0766_13439</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994602.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13439"/>
    <dbReference type="EnsemblBacteria" id="EFK56236">
        <property type="protein sequence ID" value="EFK56236"/>
        <property type="gene ID" value="HMPREF0766_13439"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_4_1_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="123"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="191" mass="22823" checksum="649947B6090D6AF6" modified="2010-10-05" version="1">MRPYSKHTESELMALMISGDHHAYLEIYDRYKTPLQQHAWKKLGHAQDVQDVIQDMFTELWIKREALQLTTGLSNYLFTAVRNRSLNQIYKRRKEAPYLDSLEEFIREGNYLIDLQVREREFRELIEKEIDNLPPRMQEVFRLSREEGLSHKQIALRLGTSEHTIAKQMTNVLKVLRKKLGPFYFIIFLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR66</accession>
    <name>D7VR66_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metal cation transporter, ZIP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gufA</name>
        <name evidence="6" type="ORF">HMPREF0766_13470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994636.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13470"/>
    <dbReference type="EnsemblBacteria" id="EFK56267">
        <property type="protein sequence ID" value="EFK56267"/>
        <property type="gene ID" value="HMPREF0766_13470"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015114_1_2_10"/>
    <dbReference type="OrthoDB" id="1469769at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK56267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="271" mass="28486" checksum="A0EB52F6D2B7FF47" modified="2010-10-05" version="1">MDELVSYLSGIDPVLAALYAGLFTWGVTAAGAALVYLFKDVNKKLLNGMLGFTGGVMVAASFWSLLSPAIEMSEGSGFSKVAPAAIGFVLGALFIFGLDKLMPHLHINFKQSEGPKSSLQRTTLLTIAIALHNIPEGLAVGVLFGGVAAGVPEASIGGAVLLAMGIGLQNFPEGIAVSMPLRRMGLSRWKSFTYGQLSAIVEPVFAVLGAMAVGFFMPVLPYALSFAAGAMIFVVIEEVIPETQQEQHSDIPILGFVIGFVIMMMLDVALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRK6</accession>
    <name>D7VRK6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Bacterial cytochrome ubiquinol oxidase</fullName>
            <ecNumber evidence="13">1.10.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cydA</name>
        <name evidence="13" type="ORF">HMPREF0766_13610</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.-" evidence="13"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13610"/>
    <dbReference type="EnsemblBacteria" id="EFK56407">
        <property type="protein sequence ID" value="EFK56407"/>
        <property type="gene ID" value="HMPREF0766_13610"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030555_3_2_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFK56407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="457" mass="50493" checksum="F22B9086858EE686" modified="2010-10-05" version="1">MLYFGVILNLFSTMDDFIAARSQMAMSLGFHIIFACVGMVMPFFMCIAHYLYLKTGNEIYKGLTKAWSRGVAILFATGAVSGTMLSFELGLLWPGFMKHAGPIFGMPFSLEGTAFFIEAIALGFFLYGWNRFNKWFHWATGLVVGISGIASGILVVAANAWMNSPAGFDYVDGKYINIDPIQAMFNDAWFSQALHMMLAAFVATGFAVAGVHALMIIKKKNVSFHTAAFRISALAACIAALLQPISGDISAKDVGKRQPAKLAAMEAHFETEARASFLIGGIPDEENGTVKYGIKVPGLLSFLAYGDIDKPVTGLHDIPRDEWPPVAITHYAFQIMIGLGMLLVLLSILYFIALFKKKSWLKSTWLFKLFVIAIPLGYIALEAGWVVTEVGRQPWIIYGIMRTIDAVTPMPGIAYSFYVFTTVFVSLSVAVIYLLYRQITMVGYLYDPTDPNFKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRM9</accession>
    <name>D7VRM9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PepSY domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994876.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13633"/>
    <dbReference type="EnsemblBacteria" id="EFK56430">
        <property type="protein sequence ID" value="EFK56430"/>
        <property type="gene ID" value="HMPREF0766_13633"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025664_1_0_10"/>
    <dbReference type="OrthoDB" id="1656356at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005625">
        <property type="entry name" value="PepSY-ass_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34219">
        <property type="entry name" value="PTHR34219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03929">
        <property type="entry name" value="PepSY_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="452"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="541" mass="62586" checksum="EB7BCB833FB83684" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRU4</accession>
    <name>D7VRU4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rieske [2Fe-2S] domain protein</fullName>
            <ecNumber evidence="5">1.7.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nirD</name>
        <name evidence="5" type="ORF">HMPREF0766_13698</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.4" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995048.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13698"/>
    <dbReference type="EnsemblBacteria" id="EFK56495">
        <property type="protein sequence ID" value="EFK56495"/>
        <property type="gene ID" value="HMPREF0766_13698"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_5_3_10"/>
    <dbReference type="OrthoDB" id="1681886at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="109" mass="12532" checksum="7E0E39B9BE9767A5" modified="2010-10-05" version="1">MQWIEIPSQFLNKPEEIRLVKVPGLNFCLTKQDGAWVAFSEKCPHAGAPLSTGWCEEGRVICPYHRHAFSLKTGRGDPGQGNFVNLYPLKQDQGKWFVGIDKKWWQKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS19</accession>
    <name>D7VS19_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995230.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13773"/>
    <dbReference type="EnsemblBacteria" id="EFK56570">
        <property type="protein sequence ID" value="EFK56570"/>
        <property type="gene ID" value="HMPREF0766_13773"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2368409_0_0_10"/>
    <dbReference type="OrthoDB" id="2007637at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="101" mass="11913" checksum="2851F3BF27024F0C" modified="2010-10-05" version="1">MIVVKVTYTVHDKYVNANKERIQDFLADFKKLDNTQFSYAVFQKEDDKTFVHLSQYQNKDIQQQLLNTASFVYFQEQRDKNLDSGPQIEFLNLIGNSKDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS30</accession>
    <name>D7VS30_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="3">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">icd</name>
        <name evidence="5" type="ORF">HMPREF0766_13784</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995257.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13784"/>
    <dbReference type="EnsemblBacteria" id="EFK56581">
        <property type="protein sequence ID" value="EFK56581"/>
        <property type="gene ID" value="HMPREF0766_13784"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_7_1_10"/>
    <dbReference type="OrthoDB" id="1551125at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004439">
        <property type="entry name" value="Isocitrate_DH_NADP_dimer_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43504">
        <property type="entry name" value="PTHR43504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00183">
        <property type="entry name" value="prok_nadp_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Iso_dh" evidence="4">
        <location>
            <begin position="20"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="420" mass="46303" checksum="A951C3CA09DA2138" modified="2010-10-05" version="1">MSSKITKDPKGQLQVPDKPVIPFIIGDGIGPDIWKAAVRVFDNAIAKAYSGQRQIGWKEVLAGEKAFEQTGEWLPEETLNTLREYLVGIKGPLTTPVGGGIRSLNVALRKDLDLYVCQRPTKWYEGVPSPVKHPEYVDMVIFRENTEDIYAGIEFAAGTPEAHKIQDYLKTQLEVDYNFSDTTGVGIKLVSEEGSKRLIRAAINFAIEQNRKSVALVHKGNIMKYTEGAFKNWGYEVAEKEFAAQTYTWGQWERTKAEKGEQAANEEQKAAEAAGKIIIKDVIADNFLQQILLNPRDYAVVATLNLNGDYISDALAAIVGGIGIAPGANINYATGHAVFEATHGTAPRFANTNTMNPSSVILSGVMMLEYMGWQEAADAIVQALSQTIREKTVTVDFYNLMTDATLVKTSEFADKIIEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSE1</accession>
    <name>D7VSE1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995523.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13895"/>
    <dbReference type="EnsemblBacteria" id="EFK56692">
        <property type="protein sequence ID" value="EFK56692"/>
        <property type="gene ID" value="HMPREF0766_13895"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZB43">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1309028_0_0_10"/>
    <dbReference type="OrthoDB" id="1942633at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107239" evidence="1">
        <location>
            <begin position="21"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="210" mass="23797" checksum="EE069A2367966D79" modified="2010-10-05" version="1">MIFRTLFAVAVFMMSFSSFAQIRTGVYFSSDKKYNEIIEELGIPVPGNPVMIVTSFVPNNGSYVWYLNESKAKAGSSLVDNPKDLHAGIFLEDHGGLIPQIIFKDFAKGLAQPRYLINFCEVDDADKNEFPEFYLTYFEESDGLDAKPLKVIVYTNTGGKKLSKSKITGWIPFQEEDQYREERDANFKLLPKAIRLKAEKILKNAKNGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSH0</accession>
    <name>D7VSH0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13924</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995574.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13924"/>
    <dbReference type="EnsemblBacteria" id="EFK56721">
        <property type="protein sequence ID" value="EFK56721"/>
        <property type="gene ID" value="HMPREF0766_13924"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008630_1_0_10"/>
    <dbReference type="OrthoDB" id="126943at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04276">
        <property type="entry name" value="ZnMc_MMP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033413">
        <property type="entry name" value="DUF5117"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033428">
        <property type="entry name" value="DUF5118"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032534">
        <property type="entry name" value="EcxA_zinc-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034032">
        <property type="entry name" value="Zn_MMP-like_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16313">
        <property type="entry name" value="DUF4953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17148">
        <property type="entry name" value="DUF5117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17162">
        <property type="entry name" value="DUF5118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5118" evidence="3">
        <location>
            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5117" evidence="2">
        <location>
            <begin position="85"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4953" evidence="1">
        <location>
            <begin position="401"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="844" mass="96268" checksum="E84F7EFADD005DA9" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSH2</accession>
    <name>D7VSH2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG4</name>
        <name evidence="1" type="ORF">HMPREF0766_13926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995576.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13926"/>
    <dbReference type="EnsemblBacteria" id="EFK56723">
        <property type="protein sequence ID" value="EFK56723"/>
        <property type="gene ID" value="HMPREF0766_13926"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_10"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="263" mass="28318" checksum="C1341692E270196D" modified="2010-10-05" version="1">MNLNLKDKVVIVTGGAKGIGRAIVLALAGEGAIPVIVGRNEADNNKVKSEVAQLGIEALCIEAELSVPEESAKAVHKTLEVYGRIDGLVNNAGVNDGVGLASGDYEKFVASLHKNLIHYYLMAHHSLEALKQSKGSIVNITSKTAETGQGNTSAYAASNGGRNALTREWAVELLPYSIRVNAIVVAESSTPQYDKWIQTLDNPEQTLKKITDRIPLEHRMTTPEEIANTTVFLLSDKSSHTTGQLIHVDGGYVHLDRSILAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSL0</accession>
    <name>D7VSL0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995625.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13964"/>
    <dbReference type="EnsemblBacteria" id="EFK56761">
        <property type="protein sequence ID" value="EFK56761"/>
        <property type="gene ID" value="HMPREF0766_13964"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_9_3_10"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="28"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="187" mass="22116" checksum="105962AECC15A908" modified="2010-10-05" version="1">MDLKEIVNDIYALPESAMLLFQEIVKEVSLPKGYTLMEADRVEDTLYFIRKGIARAYAYLENTEMTFWFGVEGSALISMRSYIEHKSGYEYIELLEDCVLYQFKTSDLQRLYESNIHIANWGRKFAERELIKTETRMINREFKTAAERYQDLMDYYPHLLQRVQLGYIASFLGITQVSLSRIRADKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSP0</accession>
    <name>D7VSP0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13994"/>
    <dbReference type="EnsemblBacteria" id="EFK56791">
        <property type="protein sequence ID" value="EFK56791"/>
        <property type="gene ID" value="HMPREF0766_13994"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50345PK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_211651_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="55" mass="6409" checksum="F2888F20A1E28CB2" modified="2010-10-05" version="1">MTMMQETAMEVLEDDVILSFNGPEDDSDDDFDEDFNLDEIDSIGEFDDFDEDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSP3</accession>
    <name>D7VSP3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein L11 methyltransferase</fullName>
            <shortName evidence="2">L11 Mtase</shortName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">prmA</name>
        <name evidence="3" type="ORF">HMPREF0766_13997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Methylates ribosomal protein L11.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:54192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13826"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the methyltransferase superfamily. PrmA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995690.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13997"/>
    <dbReference type="EnsemblBacteria" id="EFK56794">
        <property type="protein sequence ID" value="EFK56794"/>
        <property type="gene ID" value="HMPREF0766_13997"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049382_0_0_10"/>
    <dbReference type="OrthoDB" id="1712450at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00735">
        <property type="entry name" value="Methyltr_PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004498">
        <property type="entry name" value="Ribosomal_PrmA_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="279" mass="31608" checksum="27325CD75A982F10" modified="2010-10-05" version="1">MKYSEVIFTCNSAEEWQQDLLIAELAEIGFDTFEDTESGFAGYIPSANLDLQQLETVLLHAPEGLEVHYIINDLEEQNWNKLWESNFNPIVVDDQCYVRATFHEHKEQYPYEIIIDPKMSFGTGHHQTTSMMLSFILENDFEGKEVLDMGCGTGILAILASFRGATHVFAVDYDPICIDSVEENKILNQVSNIESQVGSYEVLEGRLFDTIVANINRNILLEQFEQYAASLKDKGELYISGFYDGEDLAILSDKAKQLGFSFVMKKVLDGWCSAKFTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSS6</accession>
    <name>D7VSS6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">iscS</name>
        <name evidence="10" type="ORF">HMPREF0766_14030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995766.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14030"/>
    <dbReference type="EnsemblBacteria" id="EFK56827">
        <property type="protein sequence ID" value="EFK56827"/>
        <property type="gene ID" value="HMPREF0766_14030"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_2_10"/>
    <dbReference type="OrthoDB" id="839689at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="2"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK56827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="392" mass="42860" checksum="03A3EA2EB92C618A" modified="2010-10-05" version="1">MIYLDNNATTALDPDVLEEMIPYLTLSYGNASSIQHKPGRIASAAVVKARKQIATSIHASEKEIFFNSGATEAINTVIKGVFALYSGKGKHIITSATEHKAVLACCEHLEKKGAEITYVPTDNNGMIDTSTLADLIRPDTILVALMAANNESGVIHPIEEIATITKEKNTLFFCDATQYVGKVPLNLEKTMIDILCFSAHKFHGPKGTGALYIRRKSRPTQIVPLIHGGKQEQGFRGGTYNVPAIVGMGKALELAVSDLTCQQNISDLRDLLESTILTEIPDTEVIASAVSRIANTSNITFKHTKATEIMSRLPDIAISAGSACVSGDRDPSHVLKAMHRSDEEAFCSLRFSLSRYTTEEEIKETVAKLRTVVRQIRDQSPVWQLYKDGLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSY8</accession>
    <name>D7VSY8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995886.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14092"/>
    <dbReference type="EnsemblBacteria" id="EFK56889">
        <property type="protein sequence ID" value="EFK56889"/>
        <property type="gene ID" value="HMPREF0766_14092"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001666_8_2_10"/>
    <dbReference type="OrthoDB" id="616258at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="PTHR10887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="196"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="634" mass="72066" checksum="5CD3D62841C2B85D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSZ7</accession>
    <name>D7VSZ7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995909.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14101"/>
    <dbReference type="EnsemblBacteria" id="EFK56898">
        <property type="protein sequence ID" value="EFK56898"/>
        <property type="gene ID" value="HMPREF0766_14101"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081757_2_0_10"/>
    <dbReference type="OrthoDB" id="1231841at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018644">
        <property type="entry name" value="DUF2071"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39186">
        <property type="entry name" value="PTHR39186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09844">
        <property type="entry name" value="DUF2071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="245" mass="29193" checksum="7A3E49E9F21CA98C" modified="2010-10-05" version="1">MNAIQQLLTDIGHRPWNMPASKWQYYQEWNDALFLHFEIDYTHLRKLVPAPLHIDSFDGKYYISLVAFKMQNIRPRNLPAVRFISDFYEINVRTYIDNDQKKGVYFIHIEAEKALSAFVARTLSGLPYEKSGIARKTDQYTNDNIKKNFNLHSDFRIVDKVSEKSQLDLWLTERYCLYLERKSQLWRYDIHHKEWEIHNVHMNNLLVDYKFGDIKLSPSKMIKAHYSPGVKVISWKAEKLQFKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT05</accession>
    <name>D7VT05_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atoB</name>
        <name evidence="7" type="ORF">HMPREF0766_14109</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995933.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14109"/>
    <dbReference type="EnsemblBacteria" id="EFK56906">
        <property type="protein sequence ID" value="EFK56906"/>
        <property type="gene ID" value="HMPREF0766_14109"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_1_10"/>
    <dbReference type="OrthoDB" id="1058688at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="270"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="392" mass="41189" checksum="477F15653B6CB4F1" modified="2010-10-05" version="1">MNKKVFIVAAKRTAIGSFGGALSTLSATDLGAKAVSAVLDQSGIAPEHIDEVLMGCVLQANLGQAPARQVAKISGLPDQVTATTINKVCASGMKAVSLGAQSILLGDADVVLAGGMESMSQTPYYVPAARWGAKYGSQNLIDGVQNDGLSDVYTQDAMGVFGELCAKKYTIGREEQDTYAIRSYLRSREAWETGKFTNEVVPVVIATRKGEQIIAQDEEFSQVNFDKIPSLKPAFKKDGTITAANASTISDGAAALLLVSEEKVKEWGLSPLAEIVAYADAEQAPEWFTTTPSIATEKVLKKAGLSLSDIDYFEFNEAFSVVALANAKLLNIPAEKVNIYGGAVSLGHPLGCSGARILVTLTSVLQQEQGQYGLAAICNGGGGASAVIIKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT70</accession>
    <name>D7VT70_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RteC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996078.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14174"/>
    <dbReference type="EnsemblBacteria" id="EFK56971">
        <property type="protein sequence ID" value="EFK56971"/>
        <property type="gene ID" value="HMPREF0766_14174"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9CP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079317_0_0_10"/>
    <dbReference type="OrthoDB" id="694160at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018534">
        <property type="entry name" value="Tet_reg_excision_RteC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09357">
        <property type="entry name" value="RteC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="281" mass="32912" checksum="92519AC5BEA12195" modified="2010-10-05" version="1">MEILLSKILSQIRYQEDKLASDLMPTAEKAYQMTLFLNEMLLKVKAKIVQSGFKNEQQEINFFKNIKPQILGKLIYYNKVFRFETTCPVSTGKIHQSYYENELKSLKSEYKESICNTYFYRYYRAGRTDRDHSYFMLGKINYHDGLNSGVFEIDLSFSTYYDNKIAHIIANELLYTYLLNKINPEENPDFVLLNDDVNKDISWTNSQNALIELIYALYASSSISHGSIGIRKLALIFQILFRTPVNDIHHAFHRMKTRAGSRTAFLDQLKVSLEEYMDKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTK4</accession>
    <name>D7VTK4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative toxin-antitoxin system, toxin component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996414.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14308"/>
    <dbReference type="EnsemblBacteria" id="EFK57105">
        <property type="protein sequence ID" value="EFK57105"/>
        <property type="gene ID" value="HMPREF0766_14308"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108923_8_0_10"/>
    <dbReference type="OrthoDB" id="1914312at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="149" mass="16821" checksum="C8DEC091FB972709" modified="2010-10-05" version="1">MKTNKVSLHRVIKASPEKVFRAFADPVAHATWIPPYGFLCTVQEMEFKVGGKFRMTFINFSTGNGHSFGGEYQEIIPNESIKYSDKFDDPNMPGEMTTTVSLRQVSCGTEVHIEQSGIPDMIPVEMCYLGWQESLDKMIRLVEPQIPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTS7</accession>
    <name>D7VTS7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002209.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14397"/>
    <dbReference type="EnsemblBacteria" id="EFK55706">
        <property type="protein sequence ID" value="EFK55706"/>
        <property type="gene ID" value="HMPREF0766_14397"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0767">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045686_1_1_10"/>
    <dbReference type="OrthoDB" id="1253502at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="252" mass="27549" checksum="6750EA6B8EEFE243" modified="2010-10-05" version="1">MKNKVRNLLIEFANIHRFLMRFLKEVVSPPFEIKEIIRQCYEIGWRSLPLISVTGFIVGFVFTKQSRPSLEEFGATSWLPSLISIAIIRALAPLVTALIASGKVGSQIGAELSSMNVTEQIDAMEVSGTNPFKFLIVSRVWATTIGIPILCFYTAGIGLLGGYLSIASKDDVSFLSFFTQVFEAIAYKDIFAMVFRAVVFGFTIGAVSSYCGYFSSKGTEGVGKAANSAVVASMFIVFIEEILIVQILAAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTY1</accession>
    <name>D7VTY1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="7">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">mraY</name>
        <name evidence="8" type="ORF">HMPREF0766_14451</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002298.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14451"/>
    <dbReference type="EnsemblBacteria" id="EFK55760">
        <property type="protein sequence ID" value="EFK55760"/>
        <property type="gene ID" value="HMPREF0766_14451"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023982_0_0_10"/>
    <dbReference type="OrthoDB" id="1151822at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10555">
        <property type="entry name" value="MraY_sig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK55760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="414" mass="45874" checksum="6621F4741C752174" modified="2010-10-05" version="1">MLYYLFTWLNEHIHIPGAGLFQYISFRTAMAVILSLIITTVYGSRLIRILHNKQVGETIRDLGLEGEKKKQGTPTMGGLIIIAGILVPTLLFAKIDNIYIILMIVTTLWMGAIGFLDDYIKVFKKNKEGLQGKFKVIGQVGLGVFIAVTMYFHPEIVVRQQVAHPGSLKPVEVSINSQTGEKYYTENVKSSKTNIPFYKNNEFDYAKVLTMFGLRGDMITFMVFLVMVVVIVTAVSNGANITDGIDGLAAGTSTIIGITLAILAYVSGNVIFSDYLNIMYIPNSGELVIFAGAFIGACTGFLWYNAYPAQVFMGDTGSLAIGGIIAAFAILIRKELLIPVLCGVFLIENLSVMMQVGYFKYTKKKYGEGRRIFLMSPLHHHYQKKGYHEAKIVTRFVIVGVLLAILTIVTLKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGE9</accession>
    <name>D7VGE9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK60124">
        <property type="protein sequence ID" value="EFK60124"/>
        <property type="gene ID" value="HMPREF0766_10068"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2865530_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK60124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="64" mass="7118" checksum="7AAD10370B1CFAA2" modified="2010-10-05" version="1">MATKGFKGGVGYNSKTNKMSFKFHGWDKAINNHNGGGTAKYGQNYLKSIKDMIRNSVKPTSQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGF1</accession>
    <name>D7VGF1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, alpha/beta domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10070"/>
    <dbReference type="EnsemblBacteria" id="EFK60126">
        <property type="protein sequence ID" value="EFK60126"/>
        <property type="gene ID" value="HMPREF0766_10070"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_5_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="74"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="308" mass="34111" checksum="3A671D7806618351" modified="2010-10-05" version="1">MFPNFVLLLILKLNLDRFMKNSLYVRNLIILLLITIIMTMASSSHGQQIKPTDSGYAVANGTKVYYEIYGEGRPVILLHGAYMTIDLNWGQLIPELSRTRKVIAIELQGHGHTPFSDRILSRATLASDVEGVMDYLRIESADIAGYSFGGSVAYQFAIQSPERLKKLVIISSTYKSSGWMPEVTNAFKGMKPELFANSPLQTAYDAVAPDKTKWTKFLEQMMASAKEPYDLGDDNIAKITSPVLLIAGDNDGLDKIELVKTYQLLGGAVCADFGELPPSQLAIVPSQGHRSLMMQTQTILSYLNSFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGJ3</accession>
    <name>D7VGJ3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-70 region 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10112</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996607.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10112"/>
    <dbReference type="EnsemblBacteria" id="EFK59195">
        <property type="protein sequence ID" value="EFK59195"/>
        <property type="gene ID" value="HMPREF0766_10112"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_9_3_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="33"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="130"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="192" mass="22619" checksum="C7FC591434906CB1" modified="2010-10-05" version="1">MNYSLPSYPTESGDEQLLLLYRDTGDLNYLGKLYQSHSEMVYFVCLRYLQDSERSKDAVMNIFEELISKVNKQEIHSFGKWLYVLSRNHCLMQLRSAKNKQQISIDEFVEFPGSLHPDDDHEDKEQKLTSLEHCLEKLPEKQKKSIDLFFLNEKCYNEVSEITGYSLKEVKSYIQNGKRNLKNCMEGTHEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGJ5</accession>
    <name>D7VGJ5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996612.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10114"/>
    <dbReference type="EnsemblBacteria" id="EFK59197">
        <property type="protein sequence ID" value="EFK59197"/>
        <property type="gene ID" value="HMPREF0766_10114"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070126_0_0_10"/>
    <dbReference type="OrthoDB" id="1387978at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="326" mass="37081" checksum="22605C53FE1FF1E3" modified="2010-10-05" version="1">MYLQYPKLPKKRWIYLLIPISLSFLGWNMIRTSRITLNFNRSDKVVAASILELPASNTGSFSVLTYNIAGLPEPISSAVTPRASSIANIGMKINRYDVVNVQEDFNYNRELYSNGNEHPFRTETMGKVPFSDGLNTLSKYPISDIQRIRWKDCTGADCLTPKGFSVVSLQLAKDVFVDLYNIHANAQDTPDAAVARGKNMDQLASFIKEHSKDRAILLMGDFNAHYSFELDNVRNFIKETRMIDTWVYLENKGIVPHIDPMYSAGDILAIRKDKESIDKIMFRNSADLHFIPESYAIENRLFTDKSGLPLSDHCAVSLSFSWERCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGK2</accession>
    <name>D7VGK2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsaD</name>
        <name evidence="8" type="ORF">HMPREF0766_10121</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996629.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10121"/>
    <dbReference type="EnsemblBacteria" id="EFK59204">
        <property type="protein sequence ID" value="EFK59204"/>
        <property type="gene ID" value="HMPREF0766_10121"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_0_2_10"/>
    <dbReference type="OrthoDB" id="1257362at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="7">
        <location>
            <begin position="24"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="133"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="333" mass="36097" checksum="087DE884705A8247" modified="2010-10-05" version="1">MAIILGIESSCDETSASICIDGEIKSNIIAGQAVHAKYGGVVPELASRAHQQNIIPTVDQAIREAKVHKNEIDAVAFTRGPGLLGSLLVGTSFAKSFALARNIPLIDVNHMQAHILAHFIEDPKPSFPFLCLTVSGGHTQIVLVKDYFEMELLGETLDDAAGEAFDKTAKILQLPYPGGPLVDKYAQEGNPDAFSLPEPQIADLNFSFSGLKTAILYLVQKHEKENPDFLQENLKDVCASVQARIVSILLNKVKKAAKQTGIKDIAIAGGVSANSGLRSALLAMGDRYKWNVFIPKFEYCTDNAAMIAIAGYHKYLKQDFVGQEVAPLARLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGS4</accession>
    <name>D7VGS4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996829.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10193"/>
    <dbReference type="EnsemblBacteria" id="EFK59276">
        <property type="protein sequence ID" value="EFK59276"/>
        <property type="gene ID" value="HMPREF0766_10193"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033FZR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1626020_0_0_10"/>
    <dbReference type="OrthoDB" id="1567340at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="163" mass="17612" checksum="E4D7C309E3B27EF5" modified="2010-10-05" version="1">MSEKLLITYGTRGLAQRIARLMESKMSVQLVSSEDIPGILVTSGKLLQIPGGGQSTYAHEVLKVSLDQDISYILPLGKDEISVLAEAEVLFEEYGIRLLLPGKEFMPDIFVLEDPDKDMAINILLDGKDLVSGEQIRSNGLSGAFVLSDSGEEQALCLVSAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGZ8</accession>
    <name>D7VGZ8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997042.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10267"/>
    <dbReference type="EnsemblBacteria" id="EFK59350">
        <property type="protein sequence ID" value="EFK59350"/>
        <property type="gene ID" value="HMPREF0766_10267"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2921">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175559_0_0_10"/>
    <dbReference type="OrthoDB" id="2028648at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007454">
        <property type="entry name" value="UPF0250"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027471">
        <property type="entry name" value="YbeD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04359">
        <property type="entry name" value="DUF493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117991">
        <property type="entry name" value="SSF117991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="108" mass="12421" checksum="39A3732BABD1517F" modified="2010-10-05" version="1">MSNLKNINIQDIGDGNDNQKDFYTTFKERLQDVETFPSVYTFKFILPKDEEQLNQIKSIFSGKDAQFSLKESKTGKYNSITVNVTVNDADEVVHYYQEVAKIKGVIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH17</accession>
    <name>D7VH17_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_10286</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997090.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10286"/>
    <dbReference type="EnsemblBacteria" id="EFK59369">
        <property type="protein sequence ID" value="EFK59369"/>
        <property type="gene ID" value="HMPREF0766_10286"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_2_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="107"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="437"/>
            <end position="1101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1104" mass="120298" checksum="4AB54CDCFDEDA0CB" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH52</accession>
    <name>D7VH52_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histidine biosynthesis bifunctional protein HisIE</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="13">Phosphoribosyl-AMP cyclohydrolase</fullName>
                <shortName evidence="13">PRA-CH</shortName>
                <ecNumber evidence="13">3.5.4.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="13">Phosphoribosyl-ATP pyrophosphatase</fullName>
                <shortName evidence="13">PRA-PH</shortName>
                <ecNumber evidence="13">3.6.1.31</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">hisE</name>
        <name evidence="13" type="synonym">hisI</name>
        <name evidence="13" type="synonym">hisIE</name>
        <name evidence="15" type="ORF">HMPREF0766_10321</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 13">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">In the C-terminal section; belongs to the PRA-PH family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">In the N-terminal section; belongs to the PRA-CH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="13"/>
    <dbReference type="EC" id="3.6.1.31" evidence="13"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997165.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10321"/>
    <dbReference type="EnsemblBacteria" id="EFK59404">
        <property type="protein sequence ID" value="EFK59404"/>
        <property type="gene ID" value="HMPREF0766_10321"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0139">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0140">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_3_1_10"/>
    <dbReference type="OrthoDB" id="1842189at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11534">
        <property type="entry name" value="NTP-PPase_HisIE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01020">
        <property type="entry name" value="HisE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01019">
        <property type="entry name" value="HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023019">
        <property type="entry name" value="His_synth_HisIE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="9 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRA-CH" evidence="14">
        <location>
            <begin position="25"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosyl-AMP cyclohydrolase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosyl-ATP pyrophosphohydrolase" evidence="13">
        <location>
            <begin position="106"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFK59404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="194" mass="22395" checksum="E89EF640C4FBBB0A" modified="2010-10-05" version="1">MLDFSKSDGLVPVIVQDTQTLEVLMLGYMNEEAWQKTQAERKVTFFSRSKNRLWTKGEESGNFLHVISYHIDCDQDTLLIKARPDGPTCHTGSRSCFKTQYDQNFLFELERIVNNRFEDPSDESYVNRLRSRGINKIAQKVGEEAVETVIAALTETDKEFIDETSDLLFHLIVLLREKGFSLETIAKNLESRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHD0</accession>
    <name>D7VHD0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endonuclease III</fullName>
            <ecNumber evidence="9">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">nth</name>
        <name evidence="11" type="ORF">HMPREF0766_10399</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="9"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997336.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10399"/>
    <dbReference type="EnsemblBacteria" id="EFK59482">
        <property type="protein sequence ID" value="EFK59482"/>
        <property type="gene ID" value="HMPREF0766_10399"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_3_3_10"/>
    <dbReference type="OrthoDB" id="1381897at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10576">
        <property type="entry name" value="EndIII_4Fe-2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="10">
        <location>
            <begin position="39"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK59482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="228" mass="25937" checksum="8BC39B752E6FC506" modified="2010-10-05" version="1">MLKKDRYRAFVEYFSTHNPDAQTELNYSNPYELLIAVILSAQCTDKRINQITPALFERFPVVEALAAASVDEVFSYIRSVSYPNNKAKHLVGMANMLIEKFNGEVPEQIEDLIKLPGVGRKTANVISSVVYNKPAMAVDTHVFRVSNRLGLTSRATTPLAVEKQLVKFLPEETIAVAHHWLILHGRYICLARKPKCEICPITYMCKYYETQFLKTTHRKSNSGKEQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHH8</accession>
    <name>D7VHH8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpsH</name>
        <name evidence="7" type="ORF">HMPREF0766_10447</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997477.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10447"/>
    <dbReference type="EnsemblBacteria" id="EFK59530">
        <property type="protein sequence ID" value="EFK59530"/>
        <property type="gene ID" value="HMPREF0766_10447"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098428_0_2_10"/>
    <dbReference type="OrthoDB" id="1692188at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="132" mass="14623" checksum="732AFBEE37FFEAB2" modified="2010-10-05" version="1">MNTDPIADYLTRVRNAIKANHRVVEIPASNLKKEITKVLFDKGYIANYKFEDSAVQGTIKIALKYNPISKIPAIRTLTRVSKPGLRKYASVDNLPRVLNGLGIAILSTSKGVMTDKEARVQNVGGEVLCYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHL7</accession>
    <name>D7VHL7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GumN protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0766_10486</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997546.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10486"/>
    <dbReference type="EnsemblBacteria" id="EFK59569">
        <property type="protein sequence ID" value="EFK59569"/>
        <property type="gene ID" value="HMPREF0766_10486"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057525_1_1_10"/>
    <dbReference type="OrthoDB" id="1991552at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040230">
        <property type="entry name" value="TIKI1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31120">
        <property type="entry name" value="PTHR31120"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107220" evidence="10">
        <location>
            <begin position="26"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK59569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="292" mass="33065" checksum="81B9EB959DE3E900" modified="2010-10-05" version="1">MNRNNMKNLVAFIAVVCFLINSAFAQTSPVKEKSLLWKIEGKDLKAPSYLFGTVHMLARKNFEMSAKAIDAMDKTSRVYLEINMAASNLAEESQKHMMSDKTISSQIKPEEIALVDEVLGKKLGITLAQVDKIKPMFLIAMIMQKSFSEPMASFEEEIIKHTKQEGKTIEGLSSIEEQYSFADKIFETSDFPSYLKSMDEFDIQSILSHIYQLYKEEDIAGMDELLLKYTSSNPETYRQLLPVRNHLWADRMPALMSEAPTFFAVGSGHLSGEEGVINLLRQKGYTVTPVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHN3</accession>
    <name>D7VHN3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="10">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">dusB</name>
        <name evidence="13" type="ORF">HMPREF0766_10502</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:54452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23624"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dus family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997579.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10502"/>
    <dbReference type="EnsemblBacteria" id="EFK59585">
        <property type="protein sequence ID" value="EFK59585"/>
        <property type="gene ID" value="HMPREF0766_10502"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_0_3_10"/>
    <dbReference type="OrthoDB" id="1710586at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004652">
        <property type="entry name" value="tRNA_dU_NifR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00737">
        <property type="entry name" value="nifR3_yhdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="12">
        <location>
            <begin position="18"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFK59585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="331" mass="37963" checksum="19E94A025C1204CF" modified="2010-10-05" version="1">MSVKIGDHIDLGNFPLLLAPMEDVSDPPFRYVCKQNGVDMMYTEFISSEGLIRDAAKSRQKLDIFEYERPIGIQIFGSEIEHMRQSSEICSLANPDLIDINYGCPVKNVVCKGAGSSLLQDVDKMVAMTKAVVEATHLPVTVKTRLGWDDNTKNVYEVAERLQDVGIKALSIHGRTRAQMYKGQADWSMIRDVKRNPRIKIPIFGNGDIDSVEKAAAWRQEFEVDGIMIGRASIGYPWIFREIKHFFETGQRLEGPTIVERVEVCRTHLTKSIEWKGEKTGIFEMRRHYANYFKGIPNFKEYRMKLVGLQSHHEIHEVLDEIQHQFTEEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHR0</accession>
    <name>D7VHR0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_10529</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997649.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10529"/>
    <dbReference type="EnsemblBacteria" id="EFK59612">
        <property type="protein sequence ID" value="EFK59612"/>
        <property type="gene ID" value="HMPREF0766_10529"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_2_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="4">
        <location>
            <begin position="142"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="3">
        <location>
            <begin position="439"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1098" mass="122087" checksum="9B27227C7A0164A7" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHR2</accession>
    <name>D7VHR2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RmuC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rmuC</name>
        <name evidence="4" type="ORF">HMPREF0766_10531</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RmuC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997654.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10531"/>
    <dbReference type="EnsemblBacteria" id="EFK59614">
        <property type="protein sequence ID" value="EFK59614"/>
        <property type="gene ID" value="HMPREF0766_10531"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024057_0_1_10"/>
    <dbReference type="OrthoDB" id="1309809at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003798">
        <property type="entry name" value="DNA_recombination_RmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30563">
        <property type="entry name" value="PTHR30563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02646">
        <property type="entry name" value="RmuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="32"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="442" mass="51456" checksum="83DD0F628BE185F3" modified="2010-10-05" version="1">MEWMLVTIIALLAIVLVVLFLKRKEGSGKEDYEQLRHQKDEMALELARSQQREENLIGERADLKEELEKERSERLKSDRALETAHAYLQAQQEKLEGQKKEIEETKKQFNLEFQHIANQILEEKTKKFTETNHNSITLLLDPLKEKIKTFEEKVEKTYQHESAERNVLKGVVEQLMQQSMQIRNEANNLTRALKGDSKKQGNWGEVILERVLERSGLLKDQEFRLQASVTDEDGKRLQPDAIIDLPDDKHLIVDAKISLVAYEKWVNAESEEEQKIFARQHIQSVENHVRELSAKNYHELYRIQSPDFVLLFMPIESALSMSVREKPDLFSDAWDRKVVIVSPSTLLATLRTIASMWKQERQTRNVLEIAREAGALYDKFVGFLQDMQQVEGQLQRAMERHQEATKKLGTGAGNIIRRVENLRELGAKANKQIDRKYLDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHR8</accession>
    <name>D7VHR8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_10537</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997667.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10537"/>
    <dbReference type="EnsemblBacteria" id="EFK59620">
        <property type="protein sequence ID" value="EFK59620"/>
        <property type="gene ID" value="HMPREF0766_10537"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_10"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="207" mass="23798" checksum="68B5ADF2BF8685DA" modified="2010-10-05" version="1">MKITLQDIGRRYNRDWIFRHIDYTFSVGHKYAVLGPNGSGKSTLLKVLCGNLTPSEGKINYQHEDAEIAVDRIFQYLSIAAPYVELIEDLTLREMITFHFRFKNFQNGFDQDSLLDLLGLNASINKEIRYFSSGMKQRVKLALACCSDSALVFLDEPTSNLDEKGEAWYLELIEKTISDDRLLIVCSNQAKEYSFCDQHISISDYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHY8</accession>
    <name>D7VHY8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997844.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10607"/>
    <dbReference type="EnsemblBacteria" id="EFK59690">
        <property type="protein sequence ID" value="EFK59690"/>
        <property type="gene ID" value="HMPREF0766_10607"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_602552_0_0_10"/>
    <dbReference type="OrthoDB" id="514519at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032774">
        <property type="entry name" value="WG_beta_rep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14903">
        <property type="entry name" value="WG_beta_rep"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106918" evidence="1">
        <location>
            <begin position="20"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="487" mass="55280" checksum="922450BFDE235AF9" modified="2010-10-05" version="1">MNKFYLLITLLLLSYSAQSQSPTYNIRYNFFISAELKNRLAEKKNKSTENESGSVQTISMIGNDGDLLNDIVYNRDFIRVEGKNKNAKVELIDIAKKETVLLHPTYKTFVKKTFDNAYPIVGTLSFDEDDKKQKEILGYTCNKATLTFDFSGINELDGFDPTAEIWYTKDLPRLFWRDNTYLQKIPGTMLLMTINGVGLLASVVKEVKNDPKVFEIPSNYTEQEQVYPQTEARNDSVIDATIDSAMIDNYISDSLVSFQDETTELFGVRDLEGNIVIPAAYTLLMVTGADVLIASDSNEKYGAIDLTGKVLIPFRYESLLWTAEGPVIYTENNLYGCLTREGEVLIPAQYEYINEFDGQFTAAMKDNKMGIINLKNEIVFPFTYESIIQIRNGLFIGIQDSKYYLQEFNKSNPTLSGYTYLEIGIDNDIIVAEKDNLHGYIDKSGKVLIPFKYHLASAFSDGVAYVTDEYENSFYINQKGETVNMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI42</accession>
    <name>D7VI42_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0102 protein HMPREF0766_10661</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0102 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997953.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10661"/>
    <dbReference type="EnsemblBacteria" id="EFK59744">
        <property type="protein sequence ID" value="EFK59744"/>
        <property type="gene ID" value="HMPREF0766_10661"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0792">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115353_2_3_10"/>
    <dbReference type="OrthoDB" id="2044249at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="118" mass="13363" checksum="E497232845CA0A4D" modified="2010-10-05" version="1">MAKHLEQGKKGEQMALSHLTALGYQILALNWRTGKLEVDILAYDGDILVFVEVKTRSSIAHGEPADFVDIQKQRKLIRAARACIEERGHQGDIRFDIVSVYLGEPAYIHLIKDAFWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI74</accession>
    <name>D7VI74_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bacterial sugar transferase</fullName>
            <ecNumber evidence="4">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pglC</name>
        <name evidence="4" type="ORF">HMPREF0766_10693</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998017.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10693"/>
    <dbReference type="EnsemblBacteria" id="EFK59776">
        <property type="protein sequence ID" value="EFK59776"/>
        <property type="gene ID" value="HMPREF0766_10693"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024920_1_4_10"/>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="3">
        <location>
            <begin position="7"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="203" mass="23672" checksum="8B718EF51DF00497" modified="2010-10-05" version="1">MYKYFFKRLLDIIVSVAVLLLASPVFFIVLISLFIANQGKPFFIQERPGKNEKLFRIIKFKTMNDKKDEEGNLLPDAKRLTKVGGFVRKTSLDELPQLINVFLGDMSLIGPRPLLVRYLPFYKQDERIRHSVRPGITGWAQVNGRNTAKWDDRLALDVVYVKNISFAFDMKIIYRTILKVIKSENIVIDPESIMKNLDDERRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI75</accession>
    <name>D7VI75_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, group 1 family protein</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998019.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10694"/>
    <dbReference type="EnsemblBacteria" id="EFK59777">
        <property type="protein sequence ID" value="EFK59777"/>
        <property type="gene ID" value="HMPREF0766_10694"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_8_0_10"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="64"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="191"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="379" mass="43214" checksum="B9B752A01F9FEF3C" modified="2010-10-05" version="1">MMIKPKFFIITTISDSLPFFKGQLNVLKKEFSISLVSNPGVHLQEMSLEYEVSKFPIEMEREISPLKDLKSFFKLLVLFLKEKPQLVHANTPKASLLAIMAAWFSRVPARVYYVHGLRYQSILGRKKTLLMLMERITCWFATDIIAVSNGIKETLISDNITSKDVIIIGNGSVNGIDTSFFNPDKVIKAKDDKLKPDDFVFGFVGRLVKDKGLEELVLAFQKLSKLSKNIKLLIVGSFEENMTLTKETINSIYKDPGILYVGPQKDVRPYFKAMDVFVLPSYREGFGIVLIEAGAMKIPSITTDITGCNEVIIDNQTGFLIKSKDINDLFSKMKYVLDNKNQMTMMKENARHSVHNRYSQDIVWKKAKETYLEILKNHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VID7</accession>
    <name>D7VID7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stearoyl-CoA 9-desaturase</fullName>
            <ecNumber evidence="3">1.14.19.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">desD</name>
        <name evidence="3" type="ORF">HMPREF0766_10756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.3" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998140.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10756"/>
    <dbReference type="EnsemblBacteria" id="EFK59839">
        <property type="protein sequence ID" value="EFK59839"/>
        <property type="gene ID" value="HMPREF0766_10756"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030320_0_0_10"/>
    <dbReference type="OrthoDB" id="1032884at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016213">
        <property type="term" value="F:linoleoyl-CoA desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="63"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="356" mass="41516" checksum="95F9F8ED50A8603F" modified="2010-10-05" version="1">MSKIKFINNGSSLFSKDLRNRVNQYFGTTSREKVGDFRLFLKAILLIVSALSIYVFLVFFSYPAWLGIILSIIFGCNLAGIGFNIMHDAGHDTFSANKKVNHVFSYSLNLLGGSIYFWKLKHNIAHHTYTNVQGHDHDIDVRFMRLHDDQPFRWYHRFQYIYFILLYSISYMAWVFYQDYEKYFRATMSKGGESFRFPIKEKAIFWVTKVFHLGIFIILPVCFAGWQAGITGLAIAFVSCGLCLAFVFQLAHVVSETNFPTVEEHENIKEEWMVHQLETTANFSTSNKLLSWLLGGLNYQVEHHLFPKISHIHYPEINKLVKQACKDHGISYIEFKSLRQALWSHIRHIHRMSINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIM1</accession>
    <name>D7VIM1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, PadR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998305.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10840"/>
    <dbReference type="EnsemblBacteria" id="EFK59923">
        <property type="protein sequence ID" value="EFK59923"/>
        <property type="gene ID" value="HMPREF0766_10840"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_3_1_10"/>
    <dbReference type="OrthoDB" id="1706427at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="111" mass="12585" checksum="3F24D6B8949D43CC" modified="2010-10-05" version="1">MIAENTQTQMRKGILEYCILSIISRGEIYASDIISELKKAQLLVVEGTLYPLLTRLKNNGLLSYIWKESTSGPPRKYYEITAEGLQVLEKLDVTWKELVFAVSTSIEGRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIN8</accession>
    <name>D7VIN8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10857"/>
    <dbReference type="EnsemblBacteria" id="EFK59940">
        <property type="protein sequence ID" value="EFK59940"/>
        <property type="gene ID" value="HMPREF0766_10857"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030U0N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_757981_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="385" mass="42223" checksum="E50EEF3CCED67D4E" modified="2010-10-05" version="1">MLLFIAIYSYLRQKIHFMKRYNYSKSLLFACATALLLSTFSACKKDEKTPDPQIELQLPSQLSLLYGEEKDLTLPGSLAEHGDVSLRLEYAETENITISGTTKLHDKLSQAFTIQKNQNKIHINSNVLYPNGVVSIKNGIKIPDTYKVTVVATAANGTLVGRQTVGIKVSPAKVSIKGVQNNGETPFSYVLYNDKGASFELDALKIPTTGTSWFLPKQENGDTAVSIDGNHIKFAVTAGDPHKQAEKKYDLAPALLKDGFPVASTPFQVIFIPQIKFFFGMYYPEHNLTIRLNLIHIGLSNGYVSTAPTLYPDKYKSSFSLVSVEKDGKAFTDSNNTFAVNASTGVVTVKKDDALKAGSYKFIIKAVTTTGLTFETDLTLAMSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIQ2</accession>
    <name>D7VIQ2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998374.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10871"/>
    <dbReference type="EnsemblBacteria" id="EFK59954">
        <property type="protein sequence ID" value="EFK59954"/>
        <property type="gene ID" value="HMPREF0766_10871"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013214_1_0_10"/>
    <dbReference type="OrthoDB" id="539546at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plug" evidence="1">
        <location>
            <begin position="718"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="875" mass="98262" checksum="8B4A14A11E4CF78E" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIR4</accession>
    <name>D7VIR4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10883"/>
    <dbReference type="EnsemblBacteria" id="EFK59966">
        <property type="protein sequence ID" value="EFK59966"/>
        <property type="gene ID" value="HMPREF0766_10883"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077407_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014541">
        <property type="entry name" value="Amdntrnsf_FN0238"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43224">
        <property type="entry name" value="PTHR43224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028188">
        <property type="entry name" value="Amdntrnsf_FN0238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="345" mass="39244" checksum="F6D91D5C973B7BBE" modified="2010-10-05" version="1">MEEIPYAETGKQEGPIRCSILLLQEDVNPYTMRQTTDTLLMIRPASFRKNEQTSINNYFQHTIPGWSDERINTCAQQEFDNFVSLLKQHDIRLIVIQDDGQHDTPDSIFPNNWISFHENGEVVLYPMFAENRRNERKIDIFAPLKEAGYAVTDRRDFTSSENQHLFLEGTGSLILDRVNRKAYCSLSPRADSDLVHRFCLTMDYTPVLFESFQSVGDLRKAIYHTNVMMAVGDHFAVLCADAIDNKLQRQLVIDNLHQDNKEIVFITEEQAGRFAGNILQVHSVSGASFVVMSSQAYDCLLPIQRDMLSQYGTLLKSPLNVIETCGGGSARCMMAEVFLPQQTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIV9</accession>
    <name>D7VIV9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Tetraacyldisaccharide 4'-kinase</fullName>
            <ecNumber evidence="3 13">2.7.1.130</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Lipid A 4'-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">lpxK</name>
        <name evidence="15" type="ORF">HMPREF0766_10928</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the LpxK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.130" evidence="3 13"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998494.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10928"/>
    <dbReference type="EnsemblBacteria" id="EFK60011">
        <property type="protein sequence ID" value="EFK60011"/>
        <property type="gene ID" value="HMPREF0766_10928"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1663">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038816_6_0_10"/>
    <dbReference type="OrthoDB" id="1382484at2"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009029">
        <property type="term" value="F:tetraacyldisaccharide 4'-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00409">
        <property type="entry name" value="LpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003758">
        <property type="entry name" value="LpxK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42724">
        <property type="entry name" value="PTHR42724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02606">
        <property type="entry name" value="LpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00682">
        <property type="entry name" value="lpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFK60011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="342" mass="39700" checksum="130B5DD4D9398DB8" modified="2010-10-05" version="1">MLLLRWFLFPITIIYTSIIWLRNRLYDYQLLKSKTYNIPLIVIGNLAIGGTGKSPMTEFLIRLLKDKIKLATLSRGYGRKTKGFRFVSTQSTSTEAGDEPLQFKRKFPEITVAVCEDRCYGVEQLKDKHDLIILDDAFQHRKLKPTYSILLFEYTSLSEPAILLPTGNFRDMMMESHRANIIIVTKTPEDATEEDKRKIIKKISRHNPTASIYFSKIKYDKWMDKNGSGCYTNLKETDVLLITGIANPNPLINHLQPNVNRLIHMSYSDHHAFSETDINKIEEMYKAITGSNKLILTTEKDFQRLYGTRLHHFPFYYIPIQIAFDTADYQNIERSIFSHLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ42</accession>
    <name>D7VJ42_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11011"/>
    <dbReference type="EnsemblBacteria" id="EFK59177">
        <property type="protein sequence ID" value="EFK59177"/>
        <property type="gene ID" value="HMPREF0766_11011"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042245_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106947" evidence="1">
        <location>
            <begin position="28"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="401" mass="47497" checksum="89332799F647ABB7" modified="2010-10-05" version="1">MRAIFKHIRFLLSMALCISFSVQFAFAQNRSFDFYESTFSYNADPTIIIPFSDSLSNTTIKAFYDSLASGNYQPLISDLLKYKEQYDLNDWLYYQLVRKTAQSLSAKSDNYARYTLYKWFLMTKSGYDARLAIYKDQIIFYIRNDEDISDIPFFMIDKKKYMCLNYHDYGKMFNGNGAYKPVEITIPEARKDFSYKVTRMPDFRPERYVEKQLAFKYKSKAYHFKVKLNTDVSDIFANYPGVDFETYFNIPLSKETYESLIPVLKENLKGMNQKKGVDYLMQFTRYAFLYENDEENFGKEKRLSPEQTLLNQYSDCDDRAALFFYLVKEIYDLPMITLLYPTHITMAVQFDKPIGEAILYNGKYYSICEPTPQKQNLAIGQLADNLKNQRFEIVYHYDPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ55</accession>
    <name>D7VJ55_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GtrA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11024</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000354.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11024"/>
    <dbReference type="EnsemblBacteria" id="EFK58908">
        <property type="protein sequence ID" value="EFK58908"/>
        <property type="gene ID" value="HMPREF0766_11024"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083873_8_0_10"/>
    <dbReference type="OrthoDB" id="1813832at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GtrA" evidence="6">
        <location>
            <begin position="17"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="127" mass="14164" checksum="FC01263778611177" modified="2010-10-05" version="1">MKQKIGAFIKAQASAFIGGAFDYAVMVFCKEVIGIDVKNAIRISGSLGAVVNFTLNRYWAFKKSDSPVGNQIWKFILVVLGSIFLKSEGTPLVSNLLHIDYKIGRLAVELIVSLGFNYPLQRFWVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ71</accession>
    <name>D7VJ71_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DHHA1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000404.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11040"/>
    <dbReference type="EnsemblBacteria" id="EFK58924">
        <property type="protein sequence ID" value="EFK58924"/>
        <property type="gene ID" value="HMPREF0766_11040"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039720_0_0_10"/>
    <dbReference type="OrthoDB" id="1040743at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="16"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="246"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="336" mass="37821" checksum="B6BB23686863C45F" modified="2010-10-05" version="1">MLTRNENKEILSKSDKIIITTHHKPDGDALGSSLGLYHWLKSQNHDVHIIVSSDFPTFLDWLPGRDAVLIYPDDMALCQSLIDEASLIFCLDYNALSRTNVMEGVLRASTAKKYMIDHHLDPEGFDDYRLWDPQAAATAQLIYTFIEDCVDEVSEITPEIATCLYAGIMTDTGSFRFRSTTEQVHEIISKLIRSGARNWEIHEQIYNSSTENRLKFLGHCLLNRLEVIHEYNTALFAVSKQDLEQFQVTTGDTEGLVNYALSVKGIRLAALIIDRTELIKLSLRSIGDVPCNEIARKHFNGGGHFNAAGGSSEGDLQSVVHKFKSILTEYNEILIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJE2</accession>
    <name>D7VJE2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_11111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000598.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11111"/>
    <dbReference type="EnsemblBacteria" id="EFK58995">
        <property type="protein sequence ID" value="EFK58995"/>
        <property type="gene ID" value="HMPREF0766_11111"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_10"/>
    <dbReference type="OrthoDB" id="1220708at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03218">
        <property type="entry name" value="ABC_YhbG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030921">
        <property type="entry name" value="LPS_export_LptB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04406">
        <property type="entry name" value="LPS_export_lptB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="244" mass="27607" checksum="3C407B952001F62A" modified="2010-10-05" version="1">MILKAEHLIKKYKQRVVVNDVSFHVEQGEIVGLLGPNGAGKTTSFYMIVGLIKPNEGHVFLDDQEITSDAMYQRAQKGIGYLAQEASVFRKLSVENNILAVLEIHYPNKEERLAKLEELLSEFSLHRVRKNRGDLLSGGERRRTEIARALAANPSFILLDEPFAGVDPIAVEEIQTIVSKLKTRNIGILITDHNVQETLSITDRAYLLTEGKIMLTGTPEEIADNELARKFYLGRHFELRRKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJU3</accession>
    <name>D7VJU3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prepilin-type cleavage/methylation N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998629.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11262"/>
    <dbReference type="EnsemblBacteria" id="EFK58545">
        <property type="protein sequence ID" value="EFK58545"/>
        <property type="gene ID" value="HMPREF0766_11262"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50314ZH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1601654_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="166" mass="19672" checksum="A852C1D24C8E8397" modified="2010-10-05" version="1">MNKDKLKAFTLIEITIAMLIAAVVIGLCYYTFQLFMNLSHEQQQKKNEQFQAELLQHLLVRDFDHARAIYLEDELLTIQDSSGEIKYTLSSNHILRNQYDLRTDTFQMKVLEHKGEFEGPELPVQSLINRLSLQLQQEKRIWNQSLFKNYTAQQLLRIEDLQYSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK90</accession>
    <name>D7VK90_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999037.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11409"/>
    <dbReference type="EnsemblBacteria" id="EFK58692">
        <property type="protein sequence ID" value="EFK58692"/>
        <property type="gene ID" value="HMPREF0766_11409"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073550_0_0_10"/>
    <dbReference type="OrthoDB" id="1025956at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018655">
        <property type="entry name" value="DUF2086"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09859">
        <property type="entry name" value="Oxygenase-NA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="233" mass="26976" checksum="96F2926DEE2BCE0D" modified="2010-10-05" version="1">MKEIDELNWNDITLALHNKGYALLSDVLTDQECEDLKANYSHPDAYRKTVVMERYRFGKGEYKYFDYPLPDLIEKIRRTVYPYLAAVANAWNRALHIEVEFPAEHEVLLKQCHDQQQTKATVLILKYGPGGFNTLHQDLYGEIYFPMQILLFLSEPEVDFTGGEFVLLQQIPRAQSQAIVLKPKKGDILIFTTNFRPMKGTRGYYRANMKHGVSEVYSGERYTLGIIFHDALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKB4</accession>
    <name>D7VKB4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ser/Thr phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999094.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11433"/>
    <dbReference type="EnsemblBacteria" id="EFK58716">
        <property type="protein sequence ID" value="EFK58716"/>
        <property type="gene ID" value="HMPREF0766_11433"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075478_1_0_10"/>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026336">
        <property type="entry name" value="P_estr_lig_assc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024173">
        <property type="entry name" value="Pesterase_MJ0037"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000887">
        <property type="entry name" value="Pesterase_MJ0037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04123">
        <property type="entry name" value="P_estr_lig_assc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="27"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="218" mass="25415" checksum="F67624D1C18BA5A2" modified="2010-10-05" version="1">MAKKIVLNGLDCFLLPQKVLYIPFYHLLVVSDWHLGKMKHFRKEGLFVPPVEVEEEISRLELLFQELTVERVILLGDLFHSDWNEDWTAFALFTHRYPNISFLLTRGNHDILVNAHWAEARLQIIPQYILAEGLLFSHEPVADLPAYMFNIVGHLHPGCVVRGKGRQQFRLPCFHLKNNVLTLPAYGKWTGLHILPKEDNARFFSVIYDEVVEIKEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKL4</accession>
    <name>D7VKL4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0766_11533</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999366.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11533"/>
    <dbReference type="EnsemblBacteria" id="EFK58816">
        <property type="protein sequence ID" value="EFK58816"/>
        <property type="gene ID" value="HMPREF0766_11533"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_2_10"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="166"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="227"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="358"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK58816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="574" mass="64396" checksum="2304DBE66E4C6D0D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKL9</accession>
    <name>D7VKL9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Potassium-transporting ATPase potassium-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP phosphohydrolase [potassium-transporting] A chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-binding and translocating subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-translocating ATPase A chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">kdpA</name>
        <name evidence="10" type="ORF">HMPREF0766_11538</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KdpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999375.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11538"/>
    <dbReference type="EnsemblBacteria" id="EFK58821">
        <property type="protein sequence ID" value="EFK58821"/>
        <property type="gene ID" value="HMPREF0766_11538"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018614_3_0_10"/>
    <dbReference type="OrthoDB" id="296671at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00275">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004623">
        <property type="entry name" value="KdpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607">
        <property type="entry name" value="PTHR30607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03814">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001294">
        <property type="entry name" value="K_ATPaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00680">
        <property type="entry name" value="kdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 9" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="532"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK58821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="562" mass="61278" checksum="0776C3D4B984D11B" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKQ2</accession>
    <name>D7VKQ2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine-rich domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999440.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11571"/>
    <dbReference type="EnsemblBacteria" id="EFK58854">
        <property type="protein sequence ID" value="EFK58854"/>
        <property type="gene ID" value="HMPREF0766_11571"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092359_0_0_10"/>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="23"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="149"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="264" mass="29374" checksum="55CD008EDE12FD18" modified="2010-10-05" version="1">MEDQLHIPTVAELAGKGEAPEILFWVGCAGSFDERAQRITRDICKILHHVGLKYAILGTEESCTGDPAKRAGNEFLFQMQAMTNIQVLDAYEIKKIVTACPHCFNTIKNEYPQLGGNYEVIHHTQLIQSLIDEGRLKPSDGHEFKGKKITYHDPCYLGRANEVYEAPRKVLEVLDSQLVELKRCRSNGLCCGAGGAQMFKEPEPGNKDINIERIEDVIASEAQIVAAACPFCMTMLRDGVKIKDKEAEIQVLDIAEITVKANKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKU8</accession>
    <name>D7VKU8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome c oxidase accessory protein CcoG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ccoG</name>
        <name evidence="6" type="ORF">HMPREF0766_11617</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999520.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11617"/>
    <dbReference type="EnsemblBacteria" id="EFK58900">
        <property type="protein sequence ID" value="EFK58900"/>
        <property type="gene ID" value="HMPREF0766_11617"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032118_2_0_10"/>
    <dbReference type="OrthoDB" id="1230380at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014116">
        <property type="entry name" value="Cyt_c_oxidase_cbb3_FixG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032879">
        <property type="entry name" value="FixG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13746">
        <property type="entry name" value="Fer4_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11614">
        <property type="entry name" value="FixG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02745">
        <property type="entry name" value="ccoG_rdxA_fixG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="251"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="461" mass="52798" checksum="78E9F5DB2F779D22" modified="2010-10-05" version="1">MQVTTNIQDINPPKSKKRNWIYAKKPSGKLYNYRQWFGYSLLLFLFAAPFIKIKGEPFLMFNIIERKFSIFGNLFYPQDLHIFVFGMLIAMVCIVLFTVVYGRVWCGWACPQTIFMELIFRKIEYWIEGDWTQQKKLNAAENSFEKNKKKIFKHTIFLIISFFISNIFLSYIIGADALIKIITDPLDAHIAGLISISVFTLVFYAVFSYIREIVCIAICPYGRLQSVLLDDQSTVVAYDHFRGEPRGKQRKDDHKERGDCVDCNLCVQVCPTGIDIRKGLQMECVSCTACIDACDGVMKKIGKPSRLIGFYAMGEIEHKDDFKKNNVRAIAYSIVLAVLMGVFGYMIFSRTQVGATLLRAKGSTYQLREDHTISNLYSLELINKSGKEMPFTLESEDHKLTLQLVNKINKLNKDGSAKLSFFLIINSKDVEHYKSNVRINIMSEGKKIETLKTTFIAPPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKV5</accession>
    <name>D7VKV5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM protein, TIGR01212 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_11624</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999533.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK58907">
        <property type="protein sequence ID" value="EFK58907"/>
        <property type="gene ID" value="HMPREF0766_11624"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060920_0_0_10"/>
    <dbReference type="OrthoDB" id="979208at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005911">
        <property type="entry name" value="YhcC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF1">
        <property type="entry name" value="PTHR11135:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01091">
        <property type="entry name" value="uncharacterized_CHP01210-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01212">
        <property type="entry name" value="TIGR01212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="23"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="317" mass="36351" checksum="14D308EFC8FFD789" modified="2010-10-05" version="1">MGTLLDTGQKPYNHYGSYLKEKYDGQRVFKVIVDGNFTCPNRDGSKGYGGCSYCNVDSFTPESARKLPTIKEQVEAGIERARNGYNAEKFIIYFQPNTNTYAPTHLLKMMYDEAINVCPEHTVGLSVGTRPDCIDFEKIALLESYTDRLDVDLEMGMESIYDETLTRINRGCSHRELQKALALVQNSPLEICVHTIFGFPWETREMMLRYADEINKHPQIKFVKLHHLHIVEGSIMGVQYKREPFHVFSIEEYTDFLCEFIPLLRPDIIVQRLFGLADKELLIAPNWGLGKSAIQTYIDKGLEQRNAIQGSRYKILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKY6</accession>
    <name>D7VKY6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F5/8 type C domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999631.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11655"/>
    <dbReference type="EnsemblBacteria" id="EFK58259">
        <property type="protein sequence ID" value="EFK58259"/>
        <property type="gene ID" value="HMPREF0766_11655"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002934_7_0_10"/>
    <dbReference type="OrthoDB" id="439010at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="542"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="626" mass="70087" checksum="22E8A1575A142BB1" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL39</accession>
    <name>D7VL39_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11708"/>
    <dbReference type="EnsemblBacteria" id="EFK58312">
        <property type="protein sequence ID" value="EFK58312"/>
        <property type="gene ID" value="HMPREF0766_11708"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1165235_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021862">
        <property type="entry name" value="DUF3472"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11958">
        <property type="entry name" value="DUF3472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="238" mass="27130" checksum="A5481EBBFDED8709" modified="2010-10-05" version="1">MQTNSKTERRVLFSVWDSKDAEHDATTTQHDYVSLVDRSETTTVNSFGGEGTGGQSYVKSANWKTGETVAFLMNVLPQENNSVILSAWYKLASQQQWNYIASWRAPKENRYFNGFHSFLENYGYPNGQLRREADYFNAWGKENESGKWINFNKVRFSNTDGKEGQRVDYEQGVSPRNAKHFYMSSGGYTPTVKTANEIPLATEPPLKDLSAFENRVKEALKNEALHKNSVKGKTLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLG5</accession>
    <name>D7VLG5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000106.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11835"/>
    <dbReference type="EnsemblBacteria" id="EFK58438">
        <property type="protein sequence ID" value="EFK58438"/>
        <property type="gene ID" value="HMPREF0766_11835"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030Y3G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1685470_0_0_10"/>
    <dbReference type="OrthoDB" id="1806222at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="156" mass="17930" checksum="322DB2FEF03CAE6F" modified="2010-10-05" version="1">MVNLLLNTKSVYIMKHRALSASLVFMVILIFFSCKRKDCCIPDIPNPYKNFSQEQLEKLSTDSYKKINELTTSIPCSDPTDWNMTDIRTECGLSHIVYHKSLDRTKLEQLIYNHNQIMEIYAPMVAPVINCMAYQKPSGIICQNGKATLIYNNTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLP8</accession>
    <name>D7VLP8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000292.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11918"/>
    <dbReference type="EnsemblBacteria" id="EFK58521">
        <property type="protein sequence ID" value="EFK58521"/>
        <property type="gene ID" value="HMPREF0766_11918"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2849">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_754206_0_0_10"/>
    <dbReference type="OrthoDB" id="1332503at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107292" evidence="1">
        <location>
            <begin position="25"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="370" mass="42751" checksum="DA5C991D25069415" modified="2010-10-05" version="1">MINFKKICLLSVFAFLLFSTEAQENKLVYFEKVTDSLMRFYFDNYYYLAEKNCPFKSIERVTGFNKETNTFEGNFKDFGPTGHVILTGTHTNGVKTGPFIAYHPNGKIKWEATFADGQPVNDWKFYYPDGRPMMVLNYEQGVRIMSQWDRKGKQIVKDGEGLYDFSIPFEGYSEYGYPMLRRRGRVKSGVPADRWEVYFVDEKNNSVLAADEYFSGGVFKRGDNYFTEDSYSQSDFPVLPVEYFVRAEYLVFKKCNFDDYSNFTNYLSEKIEKSFDVVKLTFKIVPGNFEYTAKLSEAGKPSRITFTKMIEDAKTQNILSAIIEVIPYYFPSLKNNLPVNDTIVVSGRLEVNEAGEIDVHSISIKRPAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM17</accession>
    <name>D7VM17_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamate--ammonia ligase, catalytic domain protein</fullName>
            <ecNumber evidence="4">6.3.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">glnA</name>
        <name evidence="4" type="ORF">HMPREF0766_12014</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001208.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12014"/>
    <dbReference type="EnsemblBacteria" id="EFK58022">
        <property type="protein sequence ID" value="EFK58022"/>
        <property type="gene ID" value="HMPREF0766_12014"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024307_0_0_10"/>
    <dbReference type="OrthoDB" id="179916at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040577">
        <property type="entry name" value="Gln-synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022147">
        <property type="entry name" value="GSIII_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18318">
        <property type="entry name" value="Gln-synt_C-ter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12437">
        <property type="entry name" value="GSIII_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="3">
        <location>
            <begin position="192"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="653"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="729" mass="81547" checksum="BA0802C0C5346E97" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM35</accession>
    <name>D7VM35_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DEAD/DEAH box helicase</fullName>
            <ecNumber evidence="11">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rhlE4</name>
        <name evidence="11" type="ORF">HMPREF0766_12032</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="11"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001258.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12032"/>
    <dbReference type="EnsemblBacteria" id="EFK58040">
        <property type="protein sequence ID" value="EFK58040"/>
        <property type="gene ID" value="HMPREF0766_12032"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_3_10"/>
    <dbReference type="OrthoDB" id="643629at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="32"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="228"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="372"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK58040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="406" mass="45285" checksum="E579878304CBEF74" modified="2010-10-05" version="1">MKFTEFGLAPLLEEGLDSMGYLDATPIQEQAIPVILQDKDLIACAQTGTGKTASYLLPILHKIEVRKSEHVNTLILAPTRELALQIDQQIMGLAYFTGATSIAVYGGGDGIGYEQQKRAIREGVNIIVATPGRLIAHMTSGKFDFSKLEHLILDEADRMLDMGFYEDILRIISYLPAKRQNLLFSATMPPKIRSLAKQILHDPTEINIAISKPSDGIKQQAYLVYDEQKTELIKTILSDDSYSSVIIFASKKEIVKRLTHELQKKGIAAEAFHSDLEQTQREEVMNKFKGKRLSVLVGTDVISRGIDVVGISLVINYDVPPDPEDYVHRVGRTARAATTGTAITFINTKDQNRFGRIEALIGNEIEKVSLPEGFSEGPVYDPKSRPAKKKFQRKKKPFRKVAKKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM38</accession>
    <name>D7VM38_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">O-Glycosyl hydrolase family 30</fullName>
            <ecNumber evidence="7">3.2.1.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">neg</name>
        <name evidence="7" type="ORF">HMPREF0766_12035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.45" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12035"/>
    <dbReference type="EnsemblBacteria" id="EFK58043">
        <property type="protein sequence ID" value="EFK58043"/>
        <property type="gene ID" value="HMPREF0766_12035"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014379_3_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="PTHR11069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00843">
        <property type="entry name" value="GLHYDRLASE30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glyco_hydro_30" evidence="5">
        <location>
            <begin position="18"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_30C" evidence="6">
        <location>
            <begin position="365"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="431" mass="48252" checksum="CE16610A1D621401" modified="2010-10-05" version="1">MSPNTITLDPAVKFQTMDGFGAAITGSTCYNLMKMKKEDRTTFLKETFSDKEGMGMSYIRIAIGCSDFSLSEYTCWDTPGIENFGLQSEEKDYIIPVLKEILAINPNLKIIGSPWTSPRWMKVNNLTELKAYNSWTGGQLNPAHYQNYGTYFVKWLQAMAAQGIKVEAITPQNEPLNKGNSASLYMTWEEQKAFVKQALGPQLRAAGLQTKIYAFDHNYNYDNIASQNDYPVNIYKDQEAASYFAGAAYHNYGGNKSELLDIHQQRPDKELIFTETSIGTWNDGRNLSTRLMEDMQEVALGTVNNWSRAVIVWNLMLDTEKGPNREGGCQTCYGAVDINSANYKTITRNSHYYIIGHLSSVVKPGATRIGASGYAADGLQYSAFQNADGSYAVVLLNNSNENRAITLNDSKNHFSYQVPAKSVVSYRWTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM68</accession>
    <name>D7VM68_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-antigen polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_12065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12065"/>
    <dbReference type="EnsemblBacteria" id="EFK58073">
        <property type="protein sequence ID" value="EFK58073"/>
        <property type="gene ID" value="HMPREF0766_12065"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030792_1_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="531"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="619" mass="71582" checksum="5E5BFF1C3994328A" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMB2</accession>
    <name>D7VMB2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gram-positive signal peptide protein, YSIRK family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12109</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001419.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12109"/>
    <dbReference type="EnsemblBacteria" id="EFK58117">
        <property type="protein sequence ID" value="EFK58117"/>
        <property type="gene ID" value="HMPREF0766_12109"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1348216_0_0_10"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107703" evidence="2">
        <location>
            <begin position="21"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="45"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="203" mass="22305" checksum="09A87042D73CAB64" modified="2010-10-05" version="1">MNKKLVLGAMSMLTATLLFSCNSENKQATQTSSEQTAAPAEDPHAGQAAHSPAQAAPPMTKEIAKVLPADFTFYKLKSGISFGKADLAKDKNSVFVLFDPGCSHCQHEATALSDNYDKIKGVNVYFVSMNDPALMASFFDTFGPKLNGKSNVELLYDRNQEFIQKFHVPSQFPANYVYGPDGQLKEHWEGDKNINEIIAAYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMH0</accession>
    <name>D7VMH0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fatty acid hydroxylase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0766_12167</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001530.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12167"/>
    <dbReference type="EnsemblBacteria" id="EFK58175">
        <property type="protein sequence ID" value="EFK58175"/>
        <property type="gene ID" value="HMPREF0766_12167"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034756_1_1_10"/>
    <dbReference type="OrthoDB" id="2048011at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid alpha-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="PTHR12863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="10">
        <location>
            <begin position="48"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK58175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="209" mass="24885" checksum="5478A8D0FBF6785C" modified="2010-10-05" version="1">MFKSDFLESLTKVHYSVPIIFYLPVIIYFSWKAMGPGEMSVWMYIGYFVFGLAFWTIFEYALHRWVFHYHPKGKFLKRVHWIFHGIHHDYPKDRLRLVMPLSASIPLATLVYFMFSLFFSNEFILAAFFAGFMIGYLIYDESHYAMHHANFKSGIMKRIKQHHMLHHYQDPEKGFGVSSAVWDVVFDSGFEDKKEKKSEKEQAEKEHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMK9</accession>
    <name>D7VMK9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992655.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12229"/>
    <dbReference type="EnsemblBacteria" id="EFK57156">
        <property type="protein sequence ID" value="EFK57156"/>
        <property type="gene ID" value="HMPREF0766_12229"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032Y0S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_205101_0_0_10"/>
    <dbReference type="OrthoDB" id="2086385at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="59" mass="6525" checksum="EC2BE253DDFF519A" modified="2010-10-05" version="1">MENYTKLKELVASIEADADKFFNNGNAAAGTRVRKGLQEIKTLAQDIRNEVTAKKNDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMV1</accession>
    <name>D7VMV1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Por_Secre_tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992818.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57248">
        <property type="protein sequence ID" value="EFK57248"/>
        <property type="gene ID" value="HMPREF0766_12321"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503349N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133293_0_0_10"/>
    <dbReference type="OrthoDB" id="1936692at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107716" description="Por_Secre_tail domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="92"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="168" mass="18380" checksum="46F9868F7CDBF67F" modified="2010-10-05" version="1">MMKFFTKIHIIKTLTNALVLMASLSFAWGSNMVLASDSSSKKMGHMYMASNASKAAKYFNNESSYDFSMSAAKIFSAAESDKLINNVKVFYNPIAEQVTVSFKLGKQNAVSIKVMDALGNEVLGLMNNTLDAGNQNLAFETNGKLSSGFYFVRVVAGTETVIKRISVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMX8</accession>
    <name>D7VMX8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992860.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12348"/>
    <dbReference type="EnsemblBacteria" id="EFK57275">
        <property type="protein sequence ID" value="EFK57275"/>
        <property type="gene ID" value="HMPREF0766_12348"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1658306_0_0_10"/>
    <dbReference type="OrthoDB" id="1390922at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="165" mass="19013" checksum="1DAC88C25B5DFAAD" modified="2010-10-05" version="1">MIIKCEQKDFNEIYEIINDASIAYKGVIPDDRWHEPYMSELELKNQIADGVEFWGYKEGNTLIGVMGIQYKGEVTLIRHAYVRTKERSKGIGRQLLAHLNSMATTPVLIGTWTDAKWAISFYLKNGFRLLERSEINVLLPRYWTIPIRQIETSVVLASSNWTSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN15</accession>
    <name>D7VN15_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_12385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992911.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12385"/>
    <dbReference type="EnsemblBacteria" id="EFK57312">
        <property type="protein sequence ID" value="EFK57312"/>
        <property type="gene ID" value="HMPREF0766_12385"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_13_3_10"/>
    <dbReference type="OrthoDB" id="1174564at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005672228" evidence="3">
        <location>
            <begin position="30"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="66"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="119"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="376" mass="42314" checksum="6ACD71AA364DB6B4" modified="2010-10-05" version="1">MLSEKIFKMKKIYYTPVLMALLLSFVSCGQGTDQTKEGEDDKQDKFCLNEEFKKKIALEPLAYRPVKEQISLTGSISYNEDDVVKFKSMLEGVVENVQFNLGQFVKRGQVLATVRSTSVNDMSNERQSLTNQIALARQKVSSTQSMFQDGLASARQVEEVRMELATLQSALQSLDANMNLYNATSHRGVFEIKAPKDGYIVEKNLNPGANINNEDQLFALSNLRQIWVMVNIYANNLQYVKNGATVAVKTLAYPDEIFTGKIQQISNVFDQDERVLKARVLLDNADLRLKPGMSADVIIDKSSLVGESLIAIPNHAIIFNNNQKYAVVYNGDCDLLVMPIKAVAENNEYTYVREGYKEGDQVITKNELIVFEELMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN56</accession>
    <name>D7VN56_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992966.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12426"/>
    <dbReference type="EnsemblBacteria" id="EFK57353">
        <property type="protein sequence ID" value="EFK57353"/>
        <property type="gene ID" value="HMPREF0766_12426"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZBM1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051630_0_0_10"/>
    <dbReference type="OrthoDB" id="1382148at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="360" mass="40002" checksum="424EB6463E66EFE5" modified="2010-10-05" version="1">MAEQTQFIKYIQKYFTGFIASVYKTINGEKNAPKYLYKQMLTPKPSVDGKWTSLLADNQNVAADVVAMDSPLPLKLRPSMGSVSGDIPKLGMELKMNENQLDQVDTMLAKNADIKDIVTEIFDDTKRCIVGVEEQKEYLFLRGFSSGIALTDNDNVGTGVRVNYGYTNQAGVPVVWSNANLATMTPVADLQREIDKADALGITIGYISIDKTSLDIARRCNEVKDLYAVANGNFSDTKPSPSNKNFPSFLEEELGVKLIVVNRSIKFEKDGAKKTVKAWDEGKAILHPDLLVGQLVWKKPVESDHQSKAVEYRQGEHGALLSKYVTHKPFGEFTDIQARNVPVINNVNEIFQLDTKTVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNH4</accession>
    <name>D7VNH4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_12544</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993119.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12544"/>
    <dbReference type="EnsemblBacteria" id="EFK57471">
        <property type="protein sequence ID" value="EFK57471"/>
        <property type="gene ID" value="HMPREF0766_12544"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_3_10"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="128"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="128"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK57471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="225" mass="26167" checksum="F803E4DBBBA08584" modified="2010-10-05" version="1">MKYNILLVEDDEDFGFMLKQYLELSGLEVRLIAHPQEAEALLDQDFTFHLAILDVMMPYMSGFTLAQKILSRYPGFPFIFLTAKDQKIDKLTGLKIGADDYITKPCDPEELVLRIQNIVRRSQPVLPVAEVKIGTYVFDRSNFLLIHPQETFRLTEREVNLLSYLWSQNRQLVTREQILEQVWGTTDFFTGRSMDVFISRLRKYLSHDPGLQINSVRGIGFDVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNU4</accession>
    <name>D7VNU4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993295.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12664"/>
    <dbReference type="EnsemblBacteria" id="EFK57591">
        <property type="protein sequence ID" value="EFK57591"/>
        <property type="gene ID" value="HMPREF0766_12664"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z86V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019967_0_0_10"/>
    <dbReference type="OrthoDB" id="760892at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025222">
        <property type="entry name" value="DUF3945"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025343">
        <property type="entry name" value="DUF4099"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13101">
        <property type="entry name" value="DUF3945"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13351">
        <property type="entry name" value="DUF4099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3945" evidence="2">
        <location>
            <begin position="265"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3945" evidence="2">
        <location>
            <begin position="366"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="488" mass="56055" checksum="CEB63207BD3E5DD2" modified="2010-10-05" version="1">MSEEKETENQQVASEQLSDILLVLDKEKMKIQAVKSIDKSGKMETVDPTKKNQSEFMRVDKHGDFVTNFLSNFWRQLKDPTKFALFKVSADEAVEKAKEFQNQINNPTAEGKKKMEKHEVKNEPEQEQKQENKNDMTKTETTPETSEYRFQPEQIDWETMNNLGLSKEYLEKKNLLDPLLRGYKTNELVPISVNLGGAVVRTDARLSLQSTPEGDVVAAVHGIRREPNLNFEFFGHKFSDEDKQNLRQTGNMGRVVDLINSKTGELMPSIISVDRLTNELIALKTDFIKIPDEVKGIKLNDEQKQTLVEGKPLFIEGMISTKGTPFDANVQFNADKRYVEFLFDRSNNDRQTQNSQQDNQQSRSQEAPKTFRGKELEDDQYNKFKDGQTVYIPNLVDKKGQTYNGYITFNKETGKTNFEFPNQYKERIKPTEAHKTQIAVNSEGKTNEATKNIKEPLQKGQQRPKNEKQQEQQNKPKAPAKSKGRKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNX5</accession>
    <name>D7VNX5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">ureD</name>
        <name evidence="5" type="ORF">HMPREF0766_12695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UreD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993344.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12695"/>
    <dbReference type="EnsemblBacteria" id="EFK57622">
        <property type="protein sequence ID" value="EFK57622"/>
        <property type="gene ID" value="HMPREF0766_12695"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056339_6_0_10"/>
    <dbReference type="OrthoDB" id="1764668at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="PTHR33643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="303" mass="34700" checksum="33985B378A73D5B4" modified="2010-10-05" version="1">MESSIKINVEREGTYSVLKESYHNAPYKLTHYGAPRAQEHLEMIIMSASPGIMDEDHLAIDIRVKKDACLKLFTQSFNKLHPMKKGATQDTIIKLEANSILQYVPHPVTPFKDAIFRATNRIDMQETATLIWGDIISAGRIYMNEAFQFQKVHSRTTLYRDGKLIYTDNQCLMPHEQPVRKLLFFEDYTHQAAFIYSGPFAKQMKEEFDEILAGSYEDITFGFTYCADNSILLRALGHDGELLYSFLTMLSQMCWEFTQHQQQLLINESVVLSQETQEAGDTEIPEPKAPAAKRKKSRKQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP46</accession>
    <name>D7VP46_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_12766</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993464.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12766"/>
    <dbReference type="EnsemblBacteria" id="EFK57693">
        <property type="protein sequence ID" value="EFK57693"/>
        <property type="gene ID" value="HMPREF0766_12766"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031275_0_2_10"/>
    <dbReference type="OrthoDB" id="944044at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK57693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="396" mass="43656" checksum="FE7853F98DD8D86C" modified="2010-10-05" version="1">MEEKKTSQPYALGLSSSLFALVLIIALMYVTQSVLVPLLFSIIISITLFPIANFLERKLHFVRSLAAIVSVIIAILIIGGLIWFIVHESIIIGKDATDITKKVMSVVESFQSWVEGRFGVQRSEMAAQFQEQSNKMLNNVGGYLSTAFGSIGSTLAGMVLVPIFIFFLLYYRDFFKEFFFKAFPNTENQKVHGVLNRIYEVIQSYFLGLVTVMGIVAVLNTVGLMIMGIEYAWFFGSLASFLMLLPYIGIAIGSILPALFALATKDNAWYAIGVIAWFQVVQFLEGNIITPNIVGGKVSINPLMAIIAILIGGMIFGLAGLILALPMTAALKVIFDAIPSMQAIGFLIGEPDKGHLKRNSTQELLTKWGIVRPARLKKKKVAETPKPKDDKNTENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPA1</accession>
    <name>D7VPA1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12821"/>
    <dbReference type="EnsemblBacteria" id="EFK57748">
        <property type="protein sequence ID" value="EFK57748"/>
        <property type="gene ID" value="HMPREF0766_12821"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3103965_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="51" mass="6002" checksum="6B9ADD514F6EEE6E" modified="2010-10-05" version="1">MTKNKSLTGKNTINYYCYIIFALKAYNMKIIFFVNISGLFTLFNKTFDAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPB6</accession>
    <name>D7VPB6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">aroA2</name>
        <name evidence="7" type="synonym">aroA</name>
        <name evidence="9" type="ORF">HMPREF0766_12836</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993599.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12836"/>
    <dbReference type="EnsemblBacteria" id="EFK57763">
        <property type="protein sequence ID" value="EFK57763"/>
        <property type="gene ID" value="HMPREF0766_12836"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024321_0_0_10"/>
    <dbReference type="OrthoDB" id="533829at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="11"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="67"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="25"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="154"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK57763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="416" mass="46012" checksum="80AE2198150B2F78" modified="2010-10-05" version="1">MEHSSIALSHPGKTIKGTVQLTGSKSESNRALIIQALSKGNVHIENLSNADDTVIMQRALKIAAEPQPETQTINIGPAGTAMRFLTSYLNLVKGNFILTGTERMQQRPIGILVDALKTLGADIHYEKKAGYPPLKIEGGMFQNKNEVSIKGNISSQYISSLLLIAAALKKGLTLHIEGELTSRPYVSMTLDMLKEAGISHTWSENAIEIAPQETKEATLYIEPDWSAASYWYAIVALSEDGHIVLPGLKQNSLQGDSAIVDIMTHFGVRSSFEQDGLHLHKSAVDSDQTLFDFKECPDLAQTVIVCAAALKRDISFTGLETLKIKETDRIAALQNEIGKFGALLLEDNGIYHLKTSNVFKPEHITIRTYEDHRMAMAFAPLALVFDQIHIEDHMVVEKSYPEFWDHLKNQNFTITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPU0</accession>
    <name>D7VPU0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_13010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993895.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13010"/>
    <dbReference type="EnsemblBacteria" id="EFK57937">
        <property type="protein sequence ID" value="EFK57937"/>
        <property type="gene ID" value="HMPREF0766_13010"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_1_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="242"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="534"/>
            <end position="1088"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1089" mass="121481" checksum="084871A6046A8210" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPU2</accession>
    <name>D7VPU2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993899.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13012"/>
    <dbReference type="EnsemblBacteria" id="EFK57939">
        <property type="protein sequence ID" value="EFK57939"/>
        <property type="gene ID" value="HMPREF0766_13012"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_962795_0_0_10"/>
    <dbReference type="OrthoDB" id="1387978at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="289" mass="31935" checksum="D87142B8F5CD5A91" modified="2010-10-05" version="1">MKSNTILYGLLSLFILVSLSSCRKSYSAGDWDILPEKETPNPVDSGSNAPTKTLKVMSVNMRLSTIPDFATMITYIKEYNPDLLFLRQIDSATTRVEKVNRPQVMADSLGMEVFFKKNFDYQTGGFGNAVLSKFPIKEKVAQILRREDGNTAELRSAVMIRVEVEKGHDVYFAGTELDPSVVNNRNLQVIDLLNMTEKITEPVILVGNFNEQESANGQVLSYLKGSFTFACLGAGCPMNSPKASPTGIYDYITFKGAGGKLALSNYLAFPKSANTFLPMTASFKLKIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPV8</accession>
    <name>D7VPV8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993926.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13028"/>
    <dbReference type="EnsemblBacteria" id="EFK57955">
        <property type="protein sequence ID" value="EFK57955"/>
        <property type="gene ID" value="HMPREF0766_13028"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_2_1_10"/>
    <dbReference type="OrthoDB" id="1579676at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005672229" evidence="2">
        <location>
            <begin position="27"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="71"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="391" mass="42982" checksum="273E8FB9B00510D9" modified="2010-10-05" version="1">MKKSRKFNLKFTTFSLGLLLSATILTHCTSGKSEEKENKNKPTALPVHTVIRSNASTVKDYLGTIEGKVNVEIRPQVEGLLQEIYADEGSFVQKGQKLFKIDASTYQEQLNNMIATANVAKAKLENAQLEIDRLRPLVQNDVISDVRLHAAKSDYDVAKASLDQASAAVRSAQISKNFTIIEAPVSGYIGRIPKRIGNLVSKGDSDPLTVLSDVQEVYVYFAMSESDFLYFSKAKAREDSIAGVKYNNNNRLTFPDVTLVLADGEAYPKKGKVDAVNGQVDRTTGAISLRATFSNQDNILRTGSTGTLKIAEIKKNVLQIPQVATQELQDKTFVYVIDKQNKAQRKTIKIAGKSKDNYIVSDGLEEGDRVILSGFDKITDGSAIMPIAQHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPW3</accession>
    <name>D7VPW3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14323"/>
    <dbReference type="EnsemblBacteria" id="EFK57120">
        <property type="protein sequence ID" value="EFK57120"/>
        <property type="gene ID" value="HMPREF0766_14323"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2425425_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="6"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="91" mass="10540" checksum="2EB91D89FF9FF1C6" modified="2010-10-05" version="1">MSQSLSKMYVHIIFHTKYNQPLIRPEVEKELYAYNGGIIKVNDSVPVKINDTQDHIHILTIMSKNIALAKLVEEIKRNSSRWIKSKGANYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPW9</accession>
    <name>D7VPW9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996448.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14329"/>
    <dbReference type="EnsemblBacteria" id="EFK57126">
        <property type="protein sequence ID" value="EFK57126"/>
        <property type="gene ID" value="HMPREF0766_14329"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099806_1_0_10"/>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019109">
        <property type="entry name" value="DUF4870"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09685">
        <property type="entry name" value="DUF4870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="195" mass="22511" checksum="2014322A37C6CBAF" modified="2010-10-05" version="1">MKENKISFNLSQKRSDKGLTQQKLAEIAGLTTRTIQRIEKGEVIPQGYTLQRIAEALDISIEELSAEIRKNNYDNQASNEMVSLFHFLPLTGLIFPFGNILFPLFLWIYFKQKNLQYDVHGRISLNFQFTITILMLSAIVLLVTYFPVGFFLLVLTTVTAIILCVFNGIRSFKNLKPMYYCSFPFLKPVPENFHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ41</accession>
    <name>D7VQ41_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="5 6">DHBP synthase</shortName>
            <ecNumber evidence="5 6">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">ribB</name>
        <name evidence="7" type="ORF">HMPREF0766_13095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5 6">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="5 6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5 6">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 5 6">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="5 6"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994032.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13095"/>
    <dbReference type="EnsemblBacteria" id="EFK55892">
        <property type="protein sequence ID" value="EFK55892"/>
        <property type="gene ID" value="HMPREF0766_13095"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_3_0_10"/>
    <dbReference type="OrthoDB" id="900513at2"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00180">
        <property type="entry name" value="RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="5">
        <location>
            <begin position="38"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="5">
        <location>
            <begin position="151"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Essential for catalytic activity" evidence="5">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="site" description="Essential for catalytic activity" evidence="5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK55892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="219" mass="24257" checksum="71A7B4D263DD284A" modified="2010-10-05" version="1">MEQRTLTYFGNTSQERVERALTDIKNGKGVLLIDNEDRENEGDLIYSAQHIQQEDMALMIRHCSGVVCLCLTDHKAEELDLPYMVAENSSLFETPFTISIEAGKGVTTGLSAADRVQTIKAASARNAKPEDLARPGHIFPLRAKKGGVLERNGHTEGSIDLMLLAGLEPQAVLCELMNDDGSMARLPQIITFAIAHRLTVLSIEDIIFYRSFVCDYTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQC5</accession>
    <name>D7VQC5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994189.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13179"/>
    <dbReference type="EnsemblBacteria" id="EFK55976">
        <property type="protein sequence ID" value="EFK55976"/>
        <property type="gene ID" value="HMPREF0766_13179"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2083362_0_0_10"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="117" mass="13309" checksum="20067FCE5F96FF5B" modified="2010-10-05" version="1">MIPSHREIAESFSSLDFDRVLPHLSDYVEWHISEKEVLKGKAALVAYSEELKASDTTGQVTLDIINVIEDDNNVVIQAKVAFGNEETGEKVRQICTVYDFDDLDHLHVIRTYTLTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQD4</accession>
    <name>D7VQD4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase</fullName>
            <ecNumber evidence="3">3.5.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ampH</name>
        <name evidence="3" type="ORF">HMPREF0766_13188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.6" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994212.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13188"/>
    <dbReference type="EnsemblBacteria" id="EFK55985">
        <property type="protein sequence ID" value="EFK55985"/>
        <property type="gene ID" value="HMPREF0766_13188"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_14_3_10"/>
    <dbReference type="OrthoDB" id="537440at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021860">
        <property type="entry name" value="Peptidase_S12_Pab87-rel_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11954">
        <property type="entry name" value="DUF3471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3471" evidence="2">
        <location>
            <begin position="426"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK55985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="520" mass="58686" checksum="1ABE78997F41BAF5" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQR6</accession>
    <name>D7VQR6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AP endonuclease, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">iolE</name>
        <name evidence="2" type="ORF">HMPREF0766_13320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994444.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13320"/>
    <dbReference type="EnsemblBacteria" id="EFK56117">
        <property type="protein sequence ID" value="EFK56117"/>
        <property type="gene ID" value="HMPREF0766_13320"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061796_0_0_10"/>
    <dbReference type="OrthoDB" id="1169054at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="29"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="350" mass="39974" checksum="DC786AD58415F7E9" modified="2010-10-05" version="1">MITIKGPAIFLAQFIGDEAPFNTLEDICQWASDLGYKGIQLPTLDTRFIDLEQAANDKNYASQLKAKVQSYGLEITELSTHLQGQLVAVNPAFDDLFDAFAPKDLHGNPKARQQWAVQQLKYAVKASHNLGLKALATFSGALLWPFVYPWPQRPENLIETGFAELARLWLPILDEGERYDVDLCYELHPGEDLHDGVTFDMFLQKVNYHNRANILYDPSHFVLQCLDYLQFIDIYHDRIKMFHVKDAEFTPSGRQGVYGGYQNWQSRAGRFRSVGDGQVDFKAVFTKLTQYNFQGWAVLEWECAFKHPEDGAREGAVFIKDYIIRVTDKAFDNFASVDTNNDLNRKLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQT4</accession>
    <name>D7VQT4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13338"/>
    <dbReference type="EnsemblBacteria" id="EFK56135">
        <property type="protein sequence ID" value="EFK56135"/>
        <property type="gene ID" value="HMPREF0766_13338"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_405279_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029456">
        <property type="entry name" value="Sialidase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14873">
        <property type="entry name" value="BNR_assoc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LamGL" evidence="2">
        <location>
            <begin position="17"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="645" mass="72954" checksum="64BF6DCC649813C1" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQX1</accession>
    <name>D7VQX1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994512.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13375"/>
    <dbReference type="EnsemblBacteria" id="EFK56172">
        <property type="protein sequence ID" value="EFK56172"/>
        <property type="gene ID" value="HMPREF0766_13375"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_690596_0_0_10"/>
    <dbReference type="OrthoDB" id="1360387at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="398" mass="45013" checksum="9D0B51F408592527" modified="2010-10-05" version="1">MTNEELTALEKASNNGDDKLISDLLTLLDGKKNFDDYKLKSSVRQFIQKENYQILNALIDKGLIETDLYEYDRFSGSVIELLIHPGITDQQALSAYLDWLPQLFNKIDDIDEEVSGVTLLQYALGIGALLGSLQILVACGADIHQKDKYDQSLLYHACNVSPVNVKNASEIVGWLLENGVEVDAANVENRTPLCRAVSTGNISLLSLLLENGADPSVQDWKGENAFYHATVHLHNKDMVKLLLQYQTPDWHMLTKQNENLLNAFLRAMLNGNEDDLEILELFFENGADPEMTSQYYSAEKSGLDWIAEKPFEVMERLLEKGYFRTDYQDNEGNTLLHKVCSFNVNYEEKAAKDLYRKVKLLLKAGTDPNIENTADKKAVDYAMEDNLKTKTVELLLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR40</accession>
    <name>D7VR40_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13444"/>
    <dbReference type="EnsemblBacteria" id="EFK56241">
        <property type="protein sequence ID" value="EFK56241"/>
        <property type="gene ID" value="HMPREF0766_13444"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061733_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032320">
        <property type="entry name" value="GH18_DUF4849"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16141">
        <property type="entry name" value="DUF4849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="339" mass="37742" checksum="6F669E9D78D509C3" modified="2010-10-05" version="1">MCNKNMLSIMNRIIIIIAAIICISMVACEKQNEYIAKEVKTVLQRSDKYYANLRAYKKSDHEIYFGWFGGTGSPGTEGIAGLMDQIPDSVDIVALWGGVPPIGSPAFKSMQKNRELKGTRFVVTMFGSGVEGLMKRNDAALFVKDVMLAIDNVAKAIADTVDKYQIDGFDLDYEPGYGDRSIFGDSGGAYATDDPHTQRLFKSLSKYLGPQSGTGKLLIIDGQSDLGIIPYIDYFMQQSYGSASGSVLQRRMRDFGGPEFPAHKFVPCENFEDLWKTGGVNFNDPQRGIMPSMLGFAYWQPLEGRKGGVGSYHTEYEYPNNPDYKYTRRAIQIMNPAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR51</accession>
    <name>D7VR51_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13455"/>
    <dbReference type="EnsemblBacteria" id="EFK56252">
        <property type="protein sequence ID" value="EFK56252"/>
        <property type="gene ID" value="HMPREF0766_13455"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033PVG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_631505_0_0_10"/>
    <dbReference type="OrthoDB" id="1245649at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107824" evidence="1">
        <location>
            <begin position="20"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="434" mass="50013" checksum="01A09F75828A4821" modified="2010-10-05" version="1">MMKQLLLFFFVCTSLSLTAQTTLPLSVADSLYEEKEFTKALQAYEKLLLQDENNSYILCKAGLCQYELKDFQKAKEKFRLAALYCAPEDKENIALYYTNLSACFSNLQDNEKAYEYAIKAYSIMEDSGIQLWNAASMAQNLGKYDECLKIMDNAKVEKNNAFLTLYGRCYMAKKLYQQCIESYEQFLANYDANDDFVTLDAEDEKGRLVIAYAFRLTSPDLSEQEIDACIARLKELWISQSADEMARTNMLNSFFKDENICSIYSYSAIICHKLFNALVTDASPVEKMQFAYYTQKNYSDALEIARGLMNNTAHLSGEELQKVKAIRYFASLRLFIADYLRKGKQVDQEQLRALAVGFNDLFEKGKMYSDEEFQQGTTEFGYMQETFTCFQNSFKTKEEQREAAPILLQIIKDLPNVNARKELTEILSKGYIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR57</accession>
    <name>D7VR57_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994627.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13461"/>
    <dbReference type="EnsemblBacteria" id="EFK56258">
        <property type="protein sequence ID" value="EFK56258"/>
        <property type="gene ID" value="HMPREF0766_13461"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1481127_0_0_10"/>
    <dbReference type="OrthoDB" id="2102989at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="183" mass="21628" checksum="EC8956675567DA62" modified="2010-10-05" version="1">MTAKEFVKNINETQISQDYLKKNYSEGFVRDVIIESNIPTLSKPFVEHGNEILNLVLNYDLSKFRVVNLNFDKDLFKDNNSIFFGWNVVNDRLGFYTDNGEVFTYYIYGDSITHYCAPNDSIFLDLLFELHKFHNNRIYDIDNQQAESLKKTFMIYINAYFGNNKKYVDFYASVIGYEEEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR82</accession>
    <name>D7VR82_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994659.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13486"/>
    <dbReference type="EnsemblBacteria" id="EFK56283">
        <property type="protein sequence ID" value="EFK56283"/>
        <property type="gene ID" value="HMPREF0766_13486"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50337SM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_882514_0_0_10"/>
    <dbReference type="OrthoDB" id="1491935at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="310" mass="36746" checksum="1C18043A81ECB220" modified="2010-10-05" version="1">MRKMQHKTEVVKNVLISIFISLFSVTALAQQTNFLIDLDSIAEEYSVSRFSLSTRDIYGTNDSVYLFNIMPKYIENPRENPEFAKDRIKYLFLFAVFPTLNSDEQWTTYEKFPHNINILSFNQLLADGPSNIELKNEPKMPDRYGILIKKGQKYYKSNISYMQTFYLNNYPSAFNVPANVININQQPISIKDMEKIYETNYKGRDLPIIPNVYPEDFDNMGLERFYLSRKFRIKNMDAYQFWTFKPRYGVSHGESWEQGIDRFIYIPDKGIVGGSFDFYFYYHRQKLGMTTLDFKNNIKQEKVMLAEQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR90</accession>
    <name>D7VR90_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994669.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13494"/>
    <dbReference type="EnsemblBacteria" id="EFK56291">
        <property type="protein sequence ID" value="EFK56291"/>
        <property type="gene ID" value="HMPREF0766_13494"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130425_0_0_10"/>
    <dbReference type="OrthoDB" id="1946004at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="176" mass="20401" checksum="23A665E33617A752" modified="2010-10-05" version="1">MKDKLLRYSLGSDLIIYALRCLIGFGIGYYIYWKFPEKELYWMLISVVLVISPEEKDAKKLAIERFKSNFIGSVIGLFCYFIPVHQVFMMLTGIILSIIVCRLFNILTVARTSMVALIIVLVHEQQQHSYFSAFERFLSVGMGCFIGLMVTLVTSYFINKLRRKLNLVRETDINTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRB8</accession>
    <name>D7VRB8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">META domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994705.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13522"/>
    <dbReference type="EnsemblBacteria" id="EFK56319">
        <property type="protein sequence ID" value="EFK56319"/>
        <property type="gene ID" value="HMPREF0766_13522"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075808_4_0_10"/>
    <dbReference type="OrthoDB" id="2029962at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005184">
        <property type="entry name" value="DUF306_Meta_HslJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025485">
        <property type="entry name" value="DUF4377"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038670">
        <property type="entry name" value="HslJ-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14302">
        <property type="entry name" value="DUF4377"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03724">
        <property type="entry name" value="META"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107472" evidence="1">
        <location>
            <begin position="23"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4377" evidence="3">
        <location>
            <begin position="30"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4377" evidence="3">
        <location>
            <begin position="120"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="META" evidence="2">
        <location>
            <begin position="211"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="318" mass="36881" checksum="FCEC67708B001546" modified="2010-10-05" version="1">MKKITPLLMCFFMVTSAITALAQSKTFSMEIKENRVDCSGVGRMKCYLVKYHNSKDWEYFYTSLDNFDYTEGYRYKVRVKRTKLSNVPADASSYKYEVVKVISKKKIKDSNDQSEEITMTVKENRVDCTGVGRMKCYMVKYDNSKDWEYFYSGFQHFNYEEGYRYKLLVKRSKLKNVPADASAYTYDVIKILSKKKISNVKEENTALAFLGKHSWKLLSLRGKMQENSGAFMNFDIDKNSVSGNSSCNNYFGTVRFNGNKITFTNVGSTQKACLNDNIEREFFDLLSLNGLTYDIAEQTFNLYHEQKLIAIFGMTQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRC1</accession>
    <name>D7VRC1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
            <ecNumber evidence="2">2.3.1.128</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.128" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994708.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13525"/>
    <dbReference type="EnsemblBacteria" id="EFK56322">
        <property type="protein sequence ID" value="EFK56322"/>
        <property type="gene ID" value="HMPREF0766_13525"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_1_10"/>
    <dbReference type="OrthoDB" id="1497607at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="174" mass="20244" checksum="B622D3745E1239F3" modified="2010-10-05" version="1">MTRVKGLNMKTERLNLHRLDMIHAEFMLRLVNTDQWKENIGDRNVNSIDEAETYVKRIIETPDIQYWVVSLTAGELPVGVVSLVKRTYLEDADIGFALLPEFEKKGYAFEAASRLLIYIRENRIQNKVLGITKNSNLKSIRLLEKLGMKRASDIEEALQQKNELIYYLYLNQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRE2</accession>
    <name>D7VRE2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13546"/>
    <dbReference type="EnsemblBacteria" id="EFK56343">
        <property type="protein sequence ID" value="EFK56343"/>
        <property type="gene ID" value="HMPREF0766_13546"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503339Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_762689_0_0_10"/>
    <dbReference type="OrthoDB" id="1623251at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027375">
        <property type="entry name" value="DKNYY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13644">
        <property type="entry name" value="DKNYY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107473" evidence="1">
        <location>
            <begin position="23"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="363" mass="41714" checksum="00FFB2D04F08EE3D" modified="2010-10-05" version="1">MLRKILYTLISCSQLGILFSCAEQIDAVSENYYIKSGKIYYIPGGNSFERGSVETGADKNTFQVLSADVAKDKAHIYYKGYAQKQVDYSSFYLENGLFKDKDHVYYSKNYSTEPGRPGNPEDRNQWNIVRLADPKTYIPLAAPNQQWAKDKSRYFYNNEPLDVDYATYSIINKSFSADKNTLYINENRLIKPTKYVPISIDSLTNRYILLNHNTLLFYAGQLAEQQIQNSKDVRVLHNNVVCIDKKVIVDGNLFHRNEADASSFEILFISTSFFVAKDKNKVYYQEDIIDGADAATYQNLYLAIGKDKDHVYSGTDIVHVPDPASFHKIDDKNFDFADNKGNQFKYVRKESKIRLQDQSGKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRH3</accession>
    <name>D7VRH3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OmpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_13577</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994769.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13577"/>
    <dbReference type="EnsemblBacteria" id="EFK56374">
        <property type="protein sequence ID" value="EFK56374"/>
        <property type="gene ID" value="HMPREF0766_13577"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058370_1_0_10"/>
    <dbReference type="OrthoDB" id="583204at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107201" evidence="3">
        <location>
            <begin position="20"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="281"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="394" mass="43788" checksum="BC4D995854049762" modified="2010-10-05" version="1">MRIISLLFIALCISLTGYSQQTIRKDTTVVVDNNKYKVITNTFWSNWFLGAGAGTQLYFGDHNKQAPLSENLTPHFGLHLGKWFSPGLGLRIGAGGYQIKGLTQNGSHSTGEVYDASKWLDKQKFNYYHVYGDMLFNLSNLFSGYNPDRIYTISPYLGAGWMVTNDAPKQREVSANLGFYNTFRLAEALDLTLDIRGSMVNDRFDGEVGGRKEEGNLSALIGLTYKFKKRGWDRSKTTVISYDEEELNALRRRVNELAANNDALSKQLEEAGNKSMTNVIVNKNILAAPILVTFKIGSSEISNETRVNLGFFAKVIKEGDQQVVYRITGYADKGTGTSEINQRLSMARAEAVKNILVNEFAVPARQLATVAAGGVDNMYYNDPKLSRAVIAFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRH4</accession>
    <name>D7VRH4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fibrobacter succinogene major paralogous domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994771.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13578"/>
    <dbReference type="EnsemblBacteria" id="EFK56375">
        <property type="protein sequence ID" value="EFK56375"/>
        <property type="gene ID" value="HMPREF0766_13578"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033V39">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_523633_0_0_10"/>
    <dbReference type="OrthoDB" id="1326773at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025049">
        <property type="entry name" value="Mfa-like_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13149">
        <property type="entry name" value="Mfa_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="520" mass="56599" checksum="F851C87786346797" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRX5</accession>
    <name>D7VRX5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995126.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13729"/>
    <dbReference type="EnsemblBacteria" id="EFK56526">
        <property type="protein sequence ID" value="EFK56526"/>
        <property type="gene ID" value="HMPREF0766_13729"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4938">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032548_0_0_10"/>
    <dbReference type="OrthoDB" id="318943at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022532">
        <property type="entry name" value="DUF3696"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014592">
        <property type="entry name" value="P-loop_UCP034888"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12476">
        <property type="entry name" value="DUF3696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034888">
        <property type="entry name" value="P-loop_UCP034888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="2">
        <location>
            <begin position="23"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3696" evidence="1">
        <location>
            <begin position="346"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="398" mass="45549" checksum="21605998881A4E07" modified="2010-10-05" version="1">MIKIIELNNFKSHKNTNIEIGNLTVLCGSNGVGKSSFIQILLLLREVFIKDKSFEILDLKSNPIKIGTVNDAVYEFGDYDGFQVKLDFDDDFICDFFYEAHSEADKVKSFINLNLDRVENKSIFEGNEWQKSFEKFSKISLFNTNFQYISAARFGPLERYEKDDKMVDVHKQISVIEGKAEYFVHYLDKYRNDDVIDELCISDEESRVYKDLFTQVLLWEKYIFNGANAEIQDVGKLGYILKYSFDNERSTTKKTAGYDAKNVGFGLSYTLPILVAILSAKKGAIIIIENPEAHLHPNGIAKLTELICIAAQAGIQIIIETHSDHIINGIAVQCKLYKNKDKKGLDKDLVKIYQFTRNEKENYTERLLIPIEEGGRIAISPEGFFDQIQIDLEKLLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRY6</accession>
    <name>D7VRY6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995151.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13740"/>
    <dbReference type="EnsemblBacteria" id="EFK56537">
        <property type="protein sequence ID" value="EFK56537"/>
        <property type="gene ID" value="HMPREF0766_13740"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104117_0_0_10"/>
    <dbReference type="OrthoDB" id="1342393at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024453">
        <property type="entry name" value="Peptidase_C92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05708">
        <property type="entry name" value="Peptidase_C92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="221" mass="25081" checksum="749D763B0858E031" modified="2010-10-05" version="1">MKKILLSLNALLLLTILISCIGKSMENPSLSQQQDQKPDQANIKEADLIFQSSLSEQSKAIQLATNSPYSHCGIIFKEGEEYVVLEAVQPVQKTALSEWIARGENSQYVIRRLKNADQILTADILTSMKKEGEKLEGRDYDIRFEWSDDNIYCSELIYKIYERAAGIKLGKLQQLKDFDFTNPAVKAQLKERYGHHIPLNETVISPASVFDSELLETIIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS26</accession>
    <name>D7VS26_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13780"/>
    <dbReference type="EnsemblBacteria" id="EFK56577">
        <property type="protein sequence ID" value="EFK56577"/>
        <property type="gene ID" value="HMPREF0766_13780"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_5_2_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="30"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="133" mass="15490" checksum="D5DADFFCDF2AC14C" modified="2010-10-05" version="1">MYGTNKNVSMTKIKETSTNYENKRALIEECPEIYAANLIGGQWTIAICCYLENGKLRFGQLKKRMPAITERMLTLQLRKMEENELVKRTVYAEVPPRVEYELTGIGIELLPIIKQLEAWGRRHQQNKQDKSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS41</accession>
    <name>D7VS41_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995286.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56592">
        <property type="protein sequence ID" value="EFK56592"/>
        <property type="gene ID" value="HMPREF0766_13795"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030NYM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1407956_0_0_10"/>
    <dbReference type="OrthoDB" id="1574356at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107516" evidence="1">
        <location>
            <begin position="22"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="212" mass="23499" checksum="8DA082949EE7B147" modified="2010-10-05" version="1">MKKLNHYLFVLLFSASFVALQSCSKDDPVPEDDQEEVGGVTLTFTEVEREAHGDHYHYNDITGAETETVSFSGNPLLPPVGAHLDLEEGKTYRLSMVAKDFAGRETQQTFVERDDIHQVFLLGAPAGTLEYVYADRKADNTKVNVGVTGYLTVLKTADSFTFRYVLRHLNPGAKAGITAADWNNVNFTKFSGENDLDLKVNLHLIHAGDHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSB9</accession>
    <name>D7VSB9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995475.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13873"/>
    <dbReference type="EnsemblBacteria" id="EFK56670">
        <property type="protein sequence ID" value="EFK56670"/>
        <property type="gene ID" value="HMPREF0766_13873"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030DT9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1214187_0_0_10"/>
    <dbReference type="OrthoDB" id="1715759at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="228" mass="25933" checksum="7C50C546501FBA30" modified="2010-10-05" version="1">MKGKKRTMLIIISSIILFILLFLHFVVGWHHIPHHLRELKDEFLSNSSSSDIHNGEAAGADTISVGVDYATRAISEPLDTLMWGRQIRAGEFVPEGVKEEYNYIKSIDFSKLSPAEDVPTDEEAQFAIVRHYKQEVVNLLKSNDAHIRIGKGYNAPLQKRDDNEQEIARVTAMVSAFNTKGINLGNIQMPLGIVYDFVKFASDPNTWYITDFSQTIPYDYELNKDRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSI5</accession>
    <name>D7VSI5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal subunit interface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">raiA</name>
        <name evidence="3" type="ORF">HMPREF0766_13939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995592.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13939"/>
    <dbReference type="EnsemblBacteria" id="EFK56736">
        <property type="protein sequence ID" value="EFK56736"/>
        <property type="gene ID" value="HMPREF0766_13939"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071472_5_2_10"/>
    <dbReference type="OrthoDB" id="2088581at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="114" mass="13159" checksum="B88FF2835B7DFE15" modified="2010-10-05" version="1">MNITVQSIKFDADQKLVDFIKKKTSKLEQFLDSIIEGVCYLRLENVDDEENKVVELKLNIPGNQLFAKAQAKSFEEATDVAVESIRRQINKHKTKTRTATSNHKELLNSEEEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSP1</accession>
    <name>D7VSP1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995686.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13995"/>
    <dbReference type="EnsemblBacteria" id="EFK56792">
        <property type="protein sequence ID" value="EFK56792"/>
        <property type="gene ID" value="HMPREF0766_13995"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_17_7_10"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="110" mass="12672" checksum="288E0C8154144593" modified="2010-10-05" version="1">MNALGKKIRLLRHQKGWSQEDVAKRLDISIPAFSKIETGITDVNLSRLNQISKLFSLSVVQLLSTSDSEEDKQYANELADMSKKLQVRETEVIELQKKVIDLYEQLHKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSP2</accession>
    <name>D7VSP2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mur ligase middle domain protein</fullName>
            <ecNumber evidence="3">6.3.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mpl</name>
        <name evidence="3" type="ORF">HMPREF0766_13996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995689.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13996"/>
    <dbReference type="EnsemblBacteria" id="EFK56793">
        <property type="protein sequence ID" value="EFK56793"/>
        <property type="gene ID" value="HMPREF0766_13996"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028104_0_2_10"/>
    <dbReference type="OrthoDB" id="307881at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="2">
        <location>
            <begin position="108"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="456" mass="52091" checksum="6D4664FB6D74B261" modified="2010-10-05" version="1">MRIHFIAIGGSIMHNLAISLANQGHQISGSDDQIVEPSRTRLLEAHLLPEEIGWFPEKITSDIDAVILGMHAEADNPELLKAQELDLKIYSFPEFVYEQSKQKTRVVIAGSYGKTTITSMIMHVLKTLGRSFDYLVGAQLEGFDRLVNLTTDNPVIIIEGDEYYASTLDHRSKFHLYHPNIALISNVEWDNFKSVISQEDYYDQFRTFIDTIVLKGTLVYNKEDKVLQSLVGETMVCKINRHGYKSPEYTINKGITYLHYGDEQIPLQVFGKHNLSNIAGAYTVCEWLGVKKQEFFEAIKSFKSSIRYLEFVASQDGSVVYQDFAHTPAKLRWSIHAVKEQFPQKELVAVIELSAYDSLNKEFLANYRGAMDEADIPVVFINKDSFKEKNKNIDHLEQDIREYFGNSSVQVVLDLSNLSYFLEDFKSKGYNLLFMSSSNYSGVNMVSFADKFFKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSQ0</accession>
    <name>D7VSQ0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tat pathway signal sequence domain protein</fullName>
            <ecNumber evidence="2">3.2.1.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nagA2</name>
        <name evidence="2" type="ORF">HMPREF0766_14004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.49" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995705.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14004"/>
    <dbReference type="EnsemblBacteria" id="EFK56801">
        <property type="protein sequence ID" value="EFK56801"/>
        <property type="gene ID" value="HMPREF0766_14004"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046965_0_0_10"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008456">
        <property type="term" value="F:alpha-N-acetylgalactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="33"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="447" mass="49998" checksum="47410D3367A7AE0D" modified="2010-10-05" version="1">MDRRNFIRTTAAASAGLGIMSSTDLFAQDGKVRLAFIGVGLRGRNHVAIALNRDDVEIVAICDTQEESLTQCRKQFDKKGVKLPKEYTGSVDAYKKMLDNEKLDAVIIATPWEFHKNQAIDAMKAGLYVGCEVIAGLTVKDHWDVVKASEQTGKPYMTLENVAYRRDVLAVLNMHRQGLFGEILHLEGGYQHDLREVLFNDGKSYYGKGVEFGPKAISEAQWRTKYNVEQDGDLYPTHGLGPIMHFADINAGNRFTHITSYSSKARGLAAYVEKMSPGHPNAKLNYKNGDITQTMLQCANGETMLLTHDTHLPRPYSIGFRVQGTKGIWMDVANGIHIEGQSKPHAWDPAADWVKKYDHPIWKKYEEVANGSGHGGMDWFVFNGFIQAVKQKRQTPIDVYDSVTMSAVFPLSTESIKAGNKTLEFPDFTSGKWKTKKNTFMLDDSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSW8</accession>
    <name>D7VSW8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ser/Thr phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995863.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14072"/>
    <dbReference type="EnsemblBacteria" id="EFK56869">
        <property type="protein sequence ID" value="EFK56869"/>
        <property type="gene ID" value="HMPREF0766_14072"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042543_0_0_10"/>
    <dbReference type="OrthoDB" id="900869at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="371" mass="42810" checksum="D2943627B3BCB172" modified="2010-10-05" version="1">MLSKAIRRNMLTLAFACTALSGYSQEKNAGLREEPHLFFENNTTSIKWVDNGVYHHVSSSDKKDFDKHIKLFSQKLDIDLKEALRQKESTTREESAFLEQYNDIEHFAAISDLHGQHDLFVRLLQQHNIIDQKGNWIYGDGHLVIVGDIMDRGDKVTESLWLLVKLEKQALSKGGRVHYVIGNHELMVFDNDLRYINQKYKDVASLFGIGYDQFFSKDSFFGRWLKQKPVIIGINNILFTHGGISPEFVEKGLTAARTNKLFTDSIFTRSKTVYRQNKELEFLTRSKGPLWYRGYFTDSTFNAQTLDFILHGLKKDHIIVGHTSHPTIVNLYDNRIFGVDSSIKNGKNGEILLYEKGIFYRGLLNGRKEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT39</accession>
    <name>D7VT39_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conjugative transposon protein TraE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">traE2</name>
        <name evidence="4" type="ORF">HMPREF0766_14143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002979435.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14143"/>
    <dbReference type="EnsemblBacteria" id="EFK56940">
        <property type="protein sequence ID" value="EFK56940"/>
        <property type="gene ID" value="HMPREF0766_14143"/>
    </dbReference>
    <dbReference type="GeneID" id="56898454"/>
    <dbReference type="GeneID" id="60809948"/>
    <dbReference type="GeneID" id="66580994"/>
    <dbReference type="eggNOG" id="ENOG5031KUP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158438_0_0_10"/>
    <dbReference type="OrthoDB" id="1636862at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025408">
        <property type="entry name" value="DUF4134"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13572">
        <property type="entry name" value="DUF4134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107554" evidence="2">
        <location>
            <begin position="24"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4134" evidence="3">
        <location>
            <begin position="9"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="101" mass="10555" checksum="EB94893200FD612F" modified="2010-10-05" version="1">MEKQRKKVLLAAVAMLSGIGAFAQGNGSAGINEATQMVTSYFDPATQLIYAIGAVVGLIGGVKVYNKFSSGDPDTSKTAASWFGACIFLIVAATILRSFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT69</accession>
    <name>D7VT69_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996076.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14173"/>
    <dbReference type="EnsemblBacteria" id="EFK56970">
        <property type="protein sequence ID" value="EFK56970"/>
        <property type="gene ID" value="HMPREF0766_14173"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZXVC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133781_0_2_10"/>
    <dbReference type="OrthoDB" id="2076478at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="37"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="117" mass="13732" checksum="A74D484DBF7EC68D" modified="2010-10-05" version="1">MKIITIEEEAWQQLNSRINAIADYLKRLNDTSYDDLWLNNHEVCQYLHISEKTLWRMRTKGEIAYSKLYGQYFYTIGAIKDMLNANAIQSNDEFVQELMAKGKSYIKKGRKLKSGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTB9</accession>
    <name>D7VTB9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter, small conductance mechanosensitive ion channel MscS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">aefA</name>
        <name evidence="9" type="ORF">HMPREF0766_14223</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996220.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14223"/>
    <dbReference type="EnsemblBacteria" id="EFK57020">
        <property type="protein sequence ID" value="EFK57020"/>
        <property type="gene ID" value="HMPREF0766_14223"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017654_0_0_10"/>
    <dbReference type="OrthoDB" id="1903165at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006686">
        <property type="entry name" value="MscS_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01246">
        <property type="entry name" value="UPF0003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107372" evidence="8">
        <location>
            <begin position="20"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="600"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK57020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="822" mass="93998" checksum="3620F50161FDB2B6" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTM1</accession>
    <name>D7VTM1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001630.1">
        <property type="nucleotide sequence ID" value="NZ_GL379777.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14341"/>
    <dbReference type="EnsemblBacteria" id="EFK55780">
        <property type="protein sequence ID" value="EFK55780"/>
        <property type="gene ID" value="HMPREF0766_14341"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093779_0_0_10"/>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="204" mass="22941" checksum="8F9E1A0785D85D4A" modified="2010-10-05" version="1">MYPILLNTIQTLESKVSNIGERKTILQPLIDFIQQKVDNKQEVNINFICTHNSRRSHLTQVWAQTAAYHFGIKNVTCYSGGTEDTALFPKVAETLFNQGFNIIKIADSYNPVYAIKYSENSQPIIGFSKKYDSLFNPVSSFAAIMTCSQADGGCPFIAGAEKRIPITFEDPKASDNTPDQIKVYAERSLQIASEMFYVFSKIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTM7</accession>
    <name>D7VTM7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_14347</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14347"/>
    <dbReference type="EnsemblBacteria" id="EFK55786">
        <property type="protein sequence ID" value="EFK55786"/>
        <property type="gene ID" value="HMPREF0766_14347"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002934_0_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107287" evidence="6">
        <location>
            <begin position="28"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK55786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="504" mass="58814" checksum="BF4C37C0C4FCA377" modified="2010-10-05" version="1">MKIYSRNKFVLLAIMIIHFVTPKMVNAQWTGPKDKPRERKELKYGPITPKNRKDNDMNAFRNYGLGQFIHWGVYAIPGNEWQGVSARKGAPASEWIRSWEGPTTPKNWLNIYDNLYKQFNPKDFAPSKWAKQAKDMGAKYMIFTTKHHDGFALWPTKYSTYNISKSPYKKDIVKEVVEAYTAEGIDVFLYFSVLEWNNPNYIDKAIETSEEKKKFKMFLEYTRNQLLELLENYPQIKGFWFDGTWDDSWINSYEFTYNLEKELREKHPGLIIGSRFRNDEFGERHFDSNGDLLGDYEQGWERKLPAKYEWLNGNDWDAVMTIPPNGWGYMKDWSGIYTKTTNDLLDMLMRSVSMDGNLVLNFGPDGNGNMHPEEDKIAKQIGEWMKVNNEAVYGVRHVELPEPKLGYYTQKDSILYLTVFNRPVNNIARISIPNKLTKVPVEAVILGQNQLLKISHSDIGIDLDENNYFDIQIPTEFQSSNPFVIKMKLGKSNYKSQKLMDAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTR6</accession>
    <name>D7VTR6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0766_14386</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001764.1">
        <property type="nucleotide sequence ID" value="NZ_GL379777.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14386"/>
    <dbReference type="EnsemblBacteria" id="EFK55825">
        <property type="protein sequence ID" value="EFK55825"/>
        <property type="gene ID" value="HMPREF0766_14386"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057657_0_0_10"/>
    <dbReference type="OrthoDB" id="1095578at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043760">
        <property type="entry name" value="DUF5706"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18967">
        <property type="entry name" value="DUF5706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="HDc" evidence="8">
        <location>
            <begin position="26"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK55825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="391" mass="44958" checksum="6B01C3930F37DE69" modified="2010-10-05" version="1">MEYDLILQKVQAYVSDFIKQHKIAELCFHNDSHTSEVVNATTEIAHHYALNKEDLFIVLCAAYFHDLGYFHGGAKQHEGRGAQLARTFLEEEGVDKHIQDQVVGCIMATRMPQQPTNLLEQILCDADLFHLGGENFETRNKLMRKEAETVGEKKIGKEEWRKQTIALMQQHHYHTDYAREKLNKEKEKNLKILLDKEKKEGKELTEDNFSKKNEERQKKPERGIETMFRITSSNNQRLSDMADNKANILLTVNSIILSMVIAVLLRKLDSNEHLVIPTIMLLSFSVSTMVVAILSTIPKVPPGVFTQEEINKKTVNLLFFGNFYKMKLEEYKEGMNRVMDDSEFLYGMLTKDVYAQGVVLGRKYKLLRIAYAIFMLGLILSSISFLISVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTS6</accession>
    <name>D7VTS6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_14396</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002208.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14396"/>
    <dbReference type="EnsemblBacteria" id="EFK55705">
        <property type="protein sequence ID" value="EFK55705"/>
        <property type="gene ID" value="HMPREF0766_14396"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_10"/>
    <dbReference type="OrthoDB" id="1058434at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030296">
        <property type="entry name" value="MlaF/Mkl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023:SF6">
        <property type="entry name" value="PTHR43023:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="16"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK55705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="258" mass="28973" checksum="DD88AA1B6E794018" modified="2010-10-05" version="1">MEKKHDYNIDYSDVVIDVKNVSKSFGTLDVLRDVNLQLFNGENLVVLGRSGTGKSVLIKLISGLLEPDQGSIHVLGQSVTELGVKELQQLRLKIGFSFQNSALYDSMTVRENLEFPLVRNKRNLTRAEINAEVEDVLEGVGLSQAINQMPSELSGGQRKRIGIARTLILRPDIMMYDEPTAGLDPITCLEINSLINEVQEKYKTSSIIITHDLACAKTVGDRIVMLLDGRFERQGSFNEIFDTDDKRVKAFYDYNFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTT7</accession>
    <name>D7VTT7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002230.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14407"/>
    <dbReference type="EnsemblBacteria" id="EFK55716">
        <property type="protein sequence ID" value="EFK55716"/>
        <property type="gene ID" value="HMPREF0766_14407"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146069_0_0_10"/>
    <dbReference type="OrthoDB" id="1903335at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="111" mass="12895" checksum="1A103D46701B241A" modified="2010-10-05" version="1">MSSKFEQLQAFLKESPSDPFLHYALANEYLKTGEDLEALSRFIKLTEQFPDYVGTYYHLGKLLEKLDRKDDALLYYQKGMEVAKAKRNMHALNELKGAYLMAIGEDDEDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTV3</accession>
    <name>D7VTV3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mltG</name>
        <name evidence="8" type="ORF">HMPREF0766_14423</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002259.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14423"/>
    <dbReference type="EnsemblBacteria" id="EFK55732">
        <property type="protein sequence ID" value="EFK55732"/>
        <property type="gene ID" value="HMPREF0766_14423"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025574_2_0_10"/>
    <dbReference type="OrthoDB" id="708179at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08010">
        <property type="entry name" value="MltG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK55732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="347" mass="40428" checksum="890B5A4030AC018F" modified="2010-10-05" version="1">MENKNRKMPKWLGIIIVLILVVGGYFSWKYYRAFFGSSVTANQEYLYIRDNSTYEQVLKDIKEKKIVDNPELFDFAATQMDYKNSVKPGRYKLTPGMNNRRLIGNLRGGYQDAVKFRFETVRLKENFAALLAKNFEADSATFIQLLNNDALAEQYGFTKDNFFTMFIPNTYEIYWNTAPEKIIARFNDEYKKFWNAERLEKAKALELTPQEVSVLASIVKGEALHRNEMPKIAGLYINRLRKGMLLQADPTVIFANQDFTIRRVLNKHLRVVSPYNTYLIRGLPPGPISLPTIASIDAVLNYEHHDFIYMVAKEDFSGYHNFSRTETEHLAYARKYQQALNDRNIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTZ6</accession>
    <name>D7VTZ6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14466"/>
    <dbReference type="EnsemblBacteria" id="EFK55775">
        <property type="protein sequence ID" value="EFK55775"/>
        <property type="gene ID" value="HMPREF0766_14466"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZI6F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1087835_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="255" mass="27893" checksum="298F013A1558883C" modified="2010-10-05" version="1" fragment="single">FTTMDPHGEKYAAWSPYNYTFNDPINTVDPDGRDGMLTGSGTKEDPYIITAKYYYVNGSLNKSEIKGLNNAITAYNKLGGKDGVEIKNSDGSVSYIKYNLSAEGVKDIEVATESAYSNKFTDVNGNERYYGNIVTPGESGAGEEFGSATNRHVNYNRNNIAKGVNSGMNENSLLTGTTIHEIGHNLGGEHSDGTSTMSQVQTTITNSQIGGSTTTYSYPSSSKEFTRTIFNRRDTRNNNSNSRVIEPGIYTRSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGA5</accession>
    <name>D7VGA5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">MEP cytidylyltransferase</fullName>
            <shortName evidence="3">MCT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">ispD</name>
        <name evidence="4" type="ORF">HMPREF0766_10024</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001875.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10024"/>
    <dbReference type="EnsemblBacteria" id="EFK60080">
        <property type="protein sequence ID" value="EFK60080"/>
        <property type="gene ID" value="HMPREF0766_10024"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061281_2_2_10"/>
    <dbReference type="OrthoDB" id="1836139at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 3 4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 4" id="KW-0808">Transferase</keyword>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="3">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="3">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK60080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="235" mass="26675" checksum="8A6BBF9461AC533C" modified="2010-10-05" version="1">MAQQYVIIVAGGTGSRMNQLLPKQYLILEDKPVLMHTIQAFYSCNTKPHIVLVLHPDMESLWTDLCRDYNFDIPHDIVYGGATRFQSVRNGLTYICTRMARPSEHLIAVHDAARPLIRPEIIDHAYELAALKQAVVVAVKSTNSIRLEKEKDGKLINSAYDRDQVWMVQTPQTFNAELLFKAYQQKESALFTDDASVVEQSGHPVTLLEGHHSNLKITYPEDIQIAQLYLNNLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGH2</accession>
    <name>D7VGH2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002040.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10091"/>
    <dbReference type="EnsemblBacteria" id="EFK60147">
        <property type="protein sequence ID" value="EFK60147"/>
        <property type="gene ID" value="HMPREF0766_10091"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9HF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034836_0_0_10"/>
    <dbReference type="OrthoDB" id="555107at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK60147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="573" mass="67247" checksum="82CBF52E84ABE0E5" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGK9</accession>
    <name>D7VGK9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996653.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10128"/>
    <dbReference type="EnsemblBacteria" id="EFK59211">
        <property type="protein sequence ID" value="EFK59211"/>
        <property type="gene ID" value="HMPREF0766_10128"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054524_1_0_10"/>
    <dbReference type="OrthoDB" id="807474at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="2">
        <location>
            <begin position="163"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="315" mass="34719" checksum="636EE135EECB5ACC" modified="2010-10-05" version="1">MKIANETKVGALTIVAIALLFIGYSFLKGNDVFSSENTFYTVYGNVDGLAVSKPVMVNGYQIGRVSKMTLMPDGQIRTEFKIKKEYEIPSNTVARIMSADLLGSKIIVFNLGNSTTLANDGDPLTSDVQQNLMEKVEPLQKKVENIAARMDSVLVAVNAILDKDFQKDVKRSVHSISVTMKNIEGITGEVNGLLGTEKARLGRIMANLESITVNFKNNGKKLDHIMNNLDNVSDQMAKIEIKSTVDKANQAMQDVQEITNKINNGDGSISLLLNDDKLYNNLNSASEELDNLIKDVKNHPGKYIRLSIFGKKDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGY6</accession>
    <name>D7VGY6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome C and quinol oxidase polypeptide I</fullName>
            <ecNumber evidence="8">1.9.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">coxN</name>
        <name evidence="8" type="ORF">HMPREF0766_10255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.9.3.1" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997007.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10255"/>
    <dbReference type="EnsemblBacteria" id="EFK59338">
        <property type="protein sequence ID" value="EFK59338"/>
        <property type="gene ID" value="HMPREF0766_10255"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011899_7_3_10"/>
    <dbReference type="OrthoDB" id="316745at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="595" mass="66901" checksum="2A6B9D6DD4C75D2B" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH15</accession>
    <name>D7VH15_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BNR/Asp-box repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997087.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10284"/>
    <dbReference type="EnsemblBacteria" id="EFK59367">
        <property type="protein sequence ID" value="EFK59367"/>
        <property type="gene ID" value="HMPREF0766_10284"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4692">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007128_1_0_10"/>
    <dbReference type="OrthoDB" id="1293876at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sialidase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="342" mass="38710" checksum="7B19053CD0192A50" modified="2010-10-05" version="1">MNRFILYCAVLLLFGSCKGIRPTVVKTGFLFEENRYFAQCHASTLAETASGEIRASWFGGTHEGNKDVVIWSSAFDGQKWSAPVSVADGISHDTVRYACWNPVLFKAKEDNTLYLYYKVGPNPREWWGAVKTSADNGKTWSSARLLPKGILGPVKNKPLELSNGIILSPSSVEVTEDRWIGNIERSDDQQKSWTSYPIDHNSPFNIIQPSILQHADGRLQVLCRSKEGFVMTSWSSDEGKNWSALSKTNMINPNSATDAIRVKNGFLIVYNPDIPGKDWWEGRARLRLAYSKDGIIWKDILVLEDQDKGEFSYPTIIQDTKDLVHITYTYNRKNIKHIILKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHA1</accession>
    <name>D7VHA1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Aldose 1-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">mro</name>
        <name evidence="12" type="ORF">HMPREF0766_10370</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="5 8"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997267.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10370"/>
    <dbReference type="EnsemblBacteria" id="EFK59453">
        <property type="protein sequence ID" value="EFK59453"/>
        <property type="gene ID" value="HMPREF0766_10370"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031753_2_0_10"/>
    <dbReference type="OrthoDB" id="1512477at2"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019318">
        <property type="term" value="P:hexose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 8 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="181"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK59453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="351" mass="39400" checksum="AF971D2605382801" modified="2010-10-05" version="1">MIYQLPSSKNFESQLKDKNTHLFILKNARGMQVALSDYGARIVSILVPDQKGNLRDVALGFDSIQKYYEADEQYHGVTAGRFANRIANGTFEINGSSYTLDQNNGINSLHGGIEGFHRRVWDRRMNQESYVEFYYVSKDGEEGFPGNLSVVVSYSLTDENEIIIKYRAESDQDTVINLTNHTYFNLNGEGNGDILNHHLQINSTEYLAVDEHQIPNAIIPVEGTAFDFREFKTIAQDIAANDEQLIAAKGYDHCFVNAIPISSPCASVFSPDSGIRMDVLTTEPGVQLYTGNWMTGNDIGKSGHKYLPYAGFCLETQHYPDSPNQPEFPTTSLKKGEVFTSETHFKFSIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHA2</accession>
    <name>D7VHA2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Argininosuccinate lyase</fullName>
            <shortName evidence="5">ASAL</shortName>
            <ecNumber evidence="3 5">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">argH</name>
        <name evidence="7" type="ORF">HMPREF0766_10371</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3 5"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997269.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10371"/>
    <dbReference type="EnsemblBacteria" id="EFK59454">
        <property type="protein sequence ID" value="EFK59454"/>
        <property type="gene ID" value="HMPREF0766_10371"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027272_2_0_10"/>
    <dbReference type="OrthoDB" id="751464at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="6">
        <location>
            <begin position="10"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="443" mass="49940" checksum="1A5741A276BD160B" modified="2010-10-05" version="1">MKIWQKNIDVDSLVETFTVGNDRVMDLQLAEADVLGSLAHTRMLNSIDLMSDEDLAVVQKELKNIYREIQEGNFQIEDSVEDVHSQVEMLLTQRIGEAGKKIHSGRSRNDQVLVDLKLYFRSEIQSIVQNTTHFFDQLLTLSEQYKQVLIPGYTHLQIAMPSSFGLWFGAYAESLVDDLELMKAAWKVCNKNPLGSAAGYGSSFPLNRTLTTELLGFEDLNYNVVYAQMGRGKTERILAQAMSAIAATLAKFAMDVTLYINQNFGFISFPAHLTTGSSIMPHKKNPDVFELIRSRCNKIQALPNEIALMTTNLPSGYHRDLQLLKENLFPAFKSLNECLEIATYMLANISVKENVLDDPKYDYLFSVEVVNNEVLKGVPFREAYKNIGLAIEEGTFQPSKEVSHTHEGSIGNLCNDHIKRMFEQVKADFGFEKVDTALQALVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHB2</accession>
    <name>D7VHB2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">bga</name>
        <name evidence="9" type="ORF">HMPREF0766_10381</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997292.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10381"/>
    <dbReference type="EnsemblBacteria" id="EFK59464">
        <property type="protein sequence ID" value="EFK59464"/>
        <property type="gene ID" value="HMPREF0766_10381"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007853_7_2_10"/>
    <dbReference type="OrthoDB" id="831762at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026283">
        <property type="entry name" value="B-gal_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="PTHR23421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006336">
        <property type="entry name" value="B-gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107210" description="Beta-galactosidase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_35" evidence="8">
        <location>
            <begin position="41"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="638" mass="72145" checksum="2938433DD60831F8" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHJ8</accession>
    <name>D7VHJ8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_10467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997507.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10467"/>
    <dbReference type="EnsemblBacteria" id="EFK59550">
        <property type="protein sequence ID" value="EFK59550"/>
        <property type="gene ID" value="HMPREF0766_10467"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_1_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106948" evidence="5">
        <location>
            <begin position="23"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="116"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="429"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1090" mass="120714" checksum="83755DF33426F546" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHK4</accession>
    <name>D7VHK4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="8">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">hisS</name>
        <name evidence="10" type="ORF">HMPREF0766_10473</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997519.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10473"/>
    <dbReference type="EnsemblBacteria" id="EFK59556">
        <property type="protein sequence ID" value="EFK59556"/>
        <property type="gene ID" value="HMPREF0766_10473"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_3_0_10"/>
    <dbReference type="OrthoDB" id="277998at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="1"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK59556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="472" mass="53226" checksum="3480E7BDD8C87FBF" modified="2010-10-05" version="1">MAIVKPSLAKGTRDFSPAEMEKRNYIFNTLKSVFRKYGYQEIQTPSFENLQTLTGKYGDEGDKLIFKILNSGDYLSKAPDALLAEKASNSLIPHLSEKALRYDLTVPFARYVVMRQHEISLPFKRFQIQPVWRADRPQRGRYREFYQCDVDVVGSESLLNEAEFILIYHEALRALGLRDFAIKINNRKILSGIAEIIGKPELIFDMTVAIDKLDKIGLDGVNKELLERGFTEADLAILRPIILLEGSTVSKIEQLRSVLAKSETGLRGVAELEEVFAYLNQLDVSGEVYNKYVELDITLARGLNYYTGCIFEVKTNEVSMGSIGGGGRYDDLTGMFGLKGLTGVGVSFGADRIYDVLEELDLYPKHESDNTRLLIVNFDKSIEAFTLPLLNRLRQAGIAVELYPQAVKLKKQMSYADDKRIPYVLLIGEEEVNTGKLSLKNMKSGEQQKLSEQEITVLLSKQRADSAIRTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHL3</accession>
    <name>D7VHL3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10482</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10482"/>
    <dbReference type="EnsemblBacteria" id="EFK59565">
        <property type="protein sequence ID" value="EFK59565"/>
        <property type="gene ID" value="HMPREF0766_10482"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079010_1_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106950" evidence="2">
        <location>
            <begin position="21"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="3">
        <location>
            <begin position="126"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="223" mass="25160" checksum="C03BBAED46D5D6C0" modified="2010-10-05" version="1">MTLMRSVITFLILFTCFGHALSAQQDTTKQFSDTLQNRMLKKNFWKQVPYKEIAIPAGLLTYGIISRESHFLIHQDNDINNVLRKNIDGKFTIDDFSQYTPLLSIYVLDLAGIKARHNLRERLFVSGVSYAIMATTVYTIKSTDNVWRPDNSANNSFPSGHAATAFAGAELLWQEYKDQSIWYGIAGYTVAAGTGFFRMYNNKHWFSDVVMGAGIGMLSTKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHX5</accession>
    <name>D7VHX5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="8 9">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 14" type="primary">miaB</name>
        <name evidence="14" type="ORF">HMPREF0766_10594</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="8 9"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997820.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10594"/>
    <dbReference type="EnsemblBacteria" id="EFK59677">
        <property type="protein sequence ID" value="EFK59677"/>
        <property type="gene ID" value="HMPREF0766_10594"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_2_1_10"/>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="12">
        <location>
            <begin position="32"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="172"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="11">
        <location>
            <begin position="414"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFK59677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="478" mass="54338" checksum="FEB933664A3D56AD" modified="2010-10-05" version="1">MIDLSHSTKEHDESRQGEALQLEASAENSNGRKLYIESYGCQMNFSDSEIVASILMDKGFETTKDFNEADVVFINTCSIRENAETRVRNRLKEFEFAKSKNPGMIVGVLGCMAERLKSKFLEEEKLVDVVVGPDAYRDLPNLIEQVDDGAKAVNVLLSREETYADINPVRLNTNGITAFISIMRGCDNMCSFCVVPFTRGRERSRDVDSIIKEAQDLFNAGYREVTLLGQNVDSYKFTAPVAEGESPAEPVNFAQLLAKVADVSPLLRVRFSTSHPKDITDEVLHTMARYENICNYIHLPVQSGNSRVLELMNRTYDRAWYIDRVDAIRRILPECGISTDVITGFCTETEEEHQETLSMMDYVKYDYAYMFAYSERPGTLAAKRYEDDIPEEIKKRRLTEVVAKQRLHSHYRIQNFVGKVHKILIEGYSKRSDQDFAGRNDQNAMVVFPVDNRYKIGDYVNVIGESCTSATLLGRIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHX8</accession>
    <name>D7VHX8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997826.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10597"/>
    <dbReference type="EnsemblBacteria" id="EFK59680">
        <property type="protein sequence ID" value="EFK59680"/>
        <property type="gene ID" value="HMPREF0766_10597"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032R1C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158672_0_0_10"/>
    <dbReference type="OrthoDB" id="1554031at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="131" mass="15096" checksum="9FC2AF254BE47A60" modified="2010-10-05" version="1">MDLEQLLKNQAGGDGQKEQKSPLESLKVDLDFYAESIKEVATEMLSEGYTLFPIFVAHQHQVSVGEVILDKTDLNTNWSINASSLEEFVERGLIKEDRKAYFERTYKKPEDYMCLFVIVPEGANFVFYPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI26</accession>
    <name>D7VI26_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">mfd</name>
        <name evidence="11" type="ORF">HMPREF0766_10645</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997921.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10645"/>
    <dbReference type="EnsemblBacteria" id="EFK59728">
        <property type="protein sequence ID" value="EFK59728"/>
        <property type="gene ID" value="HMPREF0766_10645"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005122_1_4_10"/>
    <dbReference type="OrthoDB" id="234717at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="574"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="755"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK59728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1112" mass="127147" checksum="7337E6D9933D28A7" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI28</accession>
    <name>D7VI28_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Galactokinase</fullName>
            <ecNumber evidence="11">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 15" type="primary">galK</name>
        <name evidence="15" type="ORF">HMPREF0766_10647</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="11">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="11"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997924.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10647"/>
    <dbReference type="EnsemblBacteria" id="EFK59730">
        <property type="protein sequence ID" value="EFK59730"/>
        <property type="gene ID" value="HMPREF0766_10647"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_2_1_10"/>
    <dbReference type="OrthoDB" id="1388391at2"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00246">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022963">
        <property type="entry name" value="Galactokinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="6 11 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="14">
        <location>
            <begin position="9"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="12">
        <location>
            <begin position="111"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="13">
        <location>
            <begin position="282"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="33"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="120"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFK59730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="384" mass="42932" checksum="F5C7DB0DC887D976" modified="2010-10-05" version="1">MNIQNLQDNFYNHFQQHSSIIVKSPGRINIIGEHTDYNDGFVLPAAINKAVYVAVAPRQDNNICLYAADFREMFQVSSADLQPAEKGWPNYILGVVDQIQKRGLHVGGFNLFIDGDVPAGAGLSSSAAVECATAFALNELFSLNLSRIDIARIGQLAEHTYVGVKCGIMDQFASVLSEKDQVFRLDCRSLAYEYFPLELGEYMILLLNTNVKHSLGDSQYNKRREKCELGVSWIRENYPEVKSLRDVTIEMLDEVVKKRDEDVYIKCRYVVEENLRVVAACQAMEKGDLVSLGQHIYASHKGLSKAYQVSCEELDFLVDATYAYPDVLGARMMGGGFGGCTINLVKKDFSDQFIKEISESYQQQFGVSLTPYIVETADGTTRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI51</accession>
    <name>D7VI51_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997971.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10670"/>
    <dbReference type="EnsemblBacteria" id="EFK59753">
        <property type="protein sequence ID" value="EFK59753"/>
        <property type="gene ID" value="HMPREF0766_10670"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087886_0_0_10"/>
    <dbReference type="OrthoDB" id="1105091at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107515" evidence="1">
        <location>
            <begin position="20"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="269" mass="29812" checksum="B47FB536BA62A73B" modified="2010-10-05" version="1">MKNLLISILLLVSASSVFAQTGITVGPPRTYFVAGPGQQQTQRISISNPSKDYTMELAVSFEDWQYSTYGDNQTFPKGTLATSCAAWLSTPEIYFSLKPEETKMINVNISVPKDYVALDTVPVRTAMMFVTQMNPKTGVNKEGANIRIALRSGIKLYQALPGKNNADIEIEGLKYNKGESQALELNFSNTGNIWADGQIAVELLNQENGKKTELPSSNFFTMPRDKRIFPIPLPKELENGTYLASVLISYGEKDAVKIGELEFNYEKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI68</accession>
    <name>D7VI68_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10687</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998005.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10687"/>
    <dbReference type="EnsemblBacteria" id="EFK59770">
        <property type="protein sequence ID" value="EFK59770"/>
        <property type="gene ID" value="HMPREF0766_10687"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_4_3_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014327">
        <property type="entry name" value="RNA_pol_sigma70_bacteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02985">
        <property type="entry name" value="Sig70_bacteroi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="19"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="118"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="189" mass="22396" checksum="48A5B3B47596A1B0" modified="2010-10-05" version="1">MKLTQQHIEQEIAGQFREFYLEYKDKVYRYALIHLREESQALDIVQEVFSKIWIRFEELDKNQNIKAYLYTVARNTVFDELRKIKIKHNYANTEGQRLPAVDNSNAEHIAFKDLEKVYQQAILQLPSERQRIYLLSKIEYLSNAEIADQLGISVNTVRDQLVKANKSVRAFILSHFEMSITILIFLRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIA6</accession>
    <name>D7VIA6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0766_10725</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998082.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10725"/>
    <dbReference type="EnsemblBacteria" id="EFK59808">
        <property type="protein sequence ID" value="EFK59808"/>
        <property type="gene ID" value="HMPREF0766_10725"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033697_0_0_10"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039866">
        <property type="entry name" value="CPQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12053">
        <property type="entry name" value="PTHR12053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107168" evidence="7">
        <location>
            <begin position="18"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="8">
        <location>
            <begin position="120"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="9">
        <location>
            <begin position="245"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK59808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="480" mass="53167" checksum="5412CDD8DA77FA5B" modified="2010-10-05" version="1">MNRFLFLLFLFVSPVYAQDYVNTYKQIIDEVDHHYEGYKNLRQITSTIGHRLTGSVNGRKAEQYVYDLIKSYGVQVEFQPFDARGWNRGELHVEVKVSTKDFKPVKAVSLAHAPVTSDVEASVVDLGNGLEDDYVKAGNSIKGKVALVYLGVLPGSPAGTGSLHRSEKTAIAYKYGAAGIVFINQVKGNVLLTGTASVDGELIKIPAVCIGLEDGMQLKEELKKNARGTMRIHMKNEAGMIQARNIIATFRGAKFPDEKIVVGGHLDSWDLATGAIDNGIGAFAVLDMIRAFAKLQLKTERTVQFVLFMGEEQGLLGSKAFVENLIKQHELEKVRYMINYDMTNAPTGFFSSRTEVKELFAKWGEWYAKADPTFKNIFVSGAWLHSDHQPFLLKGIPYAGGAGDKLPNNAGLYYHSDGDVFGLVSEEGMKQTTKNGLILAYSLANEDNLPVTILSGDVLKNYLIKHQLEMPLRISGDWIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D7VII4</accession>
    <name>D7VII4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cadmium-exporting ATPase</fullName>
            <ecNumber evidence="7">3.6.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cadA</name>
        <name evidence="7" type="ORF">HMPREF0766_10803</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.3" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998232.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10803"/>
    <dbReference type="EnsemblBacteria" id="EFK59886">
        <property type="protein sequence ID" value="EFK59886"/>
        <property type="gene ID" value="HMPREF0766_10803"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_6_2_10"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="608"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="634" mass="69377" checksum="2FB8FC384517AA00" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VII9</accession>
    <name>D7VII9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucosamine-6-phosphate deaminase</fullName>
            <ecNumber evidence="3">3.5.99.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nagB</name>
        <name evidence="3" type="ORF">HMPREF0766_10808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998241.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10808"/>
    <dbReference type="EnsemblBacteria" id="EFK59891">
        <property type="protein sequence ID" value="EFK59891"/>
        <property type="gene ID" value="HMPREF0766_10808"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_425041_0_0_10"/>
    <dbReference type="OrthoDB" id="54991at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="2">
        <location>
            <begin position="22"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="640" mass="72280" checksum="22248FC4FD13B9E0" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIW4</accession>
    <name>D7VIW4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="2">TMP kinase</shortName>
            <shortName evidence="2">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="2">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">thiL</name>
        <name evidence="5" type="ORF">HMPREF0766_10933</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998504.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10933"/>
    <dbReference type="EnsemblBacteria" id="EFK60016">
        <property type="protein sequence ID" value="EFK60016"/>
        <property type="gene ID" value="HMPREF0766_10933"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046964_1_0_10"/>
    <dbReference type="OrthoDB" id="1016556at2"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01379">
        <property type="entry name" value="thiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="3">
        <location>
            <begin position="39"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="4">
        <location>
            <begin position="163"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="132"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK60016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="346" mass="38205" checksum="8D66A107DF0C4E4C" modified="2010-10-05" version="1">MFENTERTNLDQMGEFGLIEHLTKHVELNEKSTIKGIGDDAAVLDFSNKKTLISTDLLLEGIHFDLRYVPLKHLGYKAVQVNLSDIYAMNGIASQITFSIGLSSKFPLEAVEEIYEGALIACKKFNVDLVGGDTSASAQGLIISVTSIGYADEDRIAYRSGAQEGDLLCVSGDLGAAYVGLQILEREKQVFLDNPKIQPDLEGKDYIIERQLKPEARKDIVQLLDSLDIKPNAMIDVSDGLASEIIHICKQSDKGCKLYEDKIPLDQMTYDTAREFGLDPTVCALNGGEDYELLFTVPQSAYDKLRNLPDITVIGYITEPNAGYEMISKSGNVYPLTAQGWNAFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIW9</accession>
    <name>D7VIW9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Glucose-inhibited division protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mnmG</name>
        <name evidence="11" type="synonym">gidA</name>
        <name evidence="14" type="ORF">HMPREF0766_10938</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MnmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998513.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10938"/>
    <dbReference type="EnsemblBacteria" id="EFK60021">
        <property type="protein sequence ID" value="EFK60021"/>
        <property type="gene ID" value="HMPREF0766_10938"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007831_2_2_10"/>
    <dbReference type="OrthoDB" id="146811at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PTHR11806:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00136">
        <property type="entry name" value="gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GIDA" evidence="12">
        <location>
            <begin position="6"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="GIDA_C" evidence="13">
        <location>
            <begin position="399"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFK60021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="619" mass="69555" checksum="48433D80BA056874" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ46</accession>
    <name>D7VJ46_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Efflux ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0766_11015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002168.1">
        <property type="nucleotide sequence ID" value="NZ_GL379779.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11015"/>
    <dbReference type="EnsemblBacteria" id="EFK59181">
        <property type="protein sequence ID" value="EFK59181"/>
        <property type="gene ID" value="HMPREF0766_11015"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035316_0_0_10"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="18"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="340"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="440" mass="47976" checksum="DE705A4FA5C68D3D" modified="2010-10-05" version="1">MNTLKIVWKNISKQLGSTILSIILTAFGAAILCVLYVTGDSFEKQLDSNSKNIDLVVGAKGSPLQLILSAVYHVDNPTGNISLAEANQLKENPFVKLAVPLSLGDNYKGHRIVGTNADFLKLYETTVEEGKYFDKPFEVVIGHAVAQKHQLKIGSKINSSHGLSASGEDHHDHPFVVVGILKKNDNITDNLILCSLESVWDVHGLAHGQASDDHHHAEEDLQEQVEAHLHHHGETEEEESHDHPHEEYVKNIGQDLIKDQGEEITAMLIQYQSPAAIAMLPKLINQSTAMQAASPAIESARLFSLLGVGIDSLTILAYIIMLMAGLSVFLSLYNALKQRKYDLAVMRTLGASKARLFAMVLLEGLIITLLGGLVGMLLGHIALFYISTQTSQSAGLIEVFSINPDEWWILLIACVIGVLSALIPSVKAYNTTISNTLSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJE5</accession>
    <name>D7VJE5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="5">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="5">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="5">IPP transferase</shortName>
            <shortName evidence="5">IPPT</shortName>
            <shortName evidence="5">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">miaA</name>
        <name evidence="9" type="ORF">HMPREF0766_11114</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5 7">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000601.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11114"/>
    <dbReference type="EnsemblBacteria" id="EFK58998">
        <property type="protein sequence ID" value="EFK58998"/>
        <property type="gene ID" value="HMPREF0766_11114"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032616_0_1_10"/>
    <dbReference type="OrthoDB" id="1069591at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <begin position="36"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <begin position="160"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK58998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="302" mass="34260" checksum="C5A5B584BA27727F" modified="2010-10-05" version="1">MKQKTLIAIVGPTAVGKTAMAIQIAKYYKTEIISADSRQFYKEMCIGTAKPSKEELASVPHHFVDSHSVGEEYSAGDFERDALAKLEELFTHHDVVVLVGGSGLFVRAVCEGLDNLPKPLPGIREALNERLEAEGIEILQNYLQEVDPLYFSEVDIDNSQRIIRALEVYESTGKPFSFYRQHTVADRPFNIITVALNTDRTQLYDRINRRVDLMIQAGLVEEVKGLMPYRDKPALLTVGYAEIFDYLACKISLEEAVDKIKQNSRRYAKRQITWFKKDTGTRWFEPDDQEGILSYTDSLLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJG6</accession>
    <name>D7VJG6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11135"/>
    <dbReference type="EnsemblBacteria" id="EFK59019">
        <property type="protein sequence ID" value="EFK59019"/>
        <property type="gene ID" value="HMPREF0766_11135"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2956">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_2_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="23"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="378"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="526" mass="58402" checksum="AA6B2CF4F2FC9363" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJQ9</accession>
    <name>D7VJQ9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR substrate binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000834.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11228"/>
    <dbReference type="EnsemblBacteria" id="EFK59112">
        <property type="protein sequence ID" value="EFK59112"/>
        <property type="gene ID" value="HMPREF0766_11228"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_10"/>
    <dbReference type="OrthoDB" id="1439189at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="297" mass="34082" checksum="C2F5DA9A64A0AF74" modified="2010-10-05" version="1">MSNQIELRHLIYFSTLAEELHFRKAAERLFISQPGLTRQIKQMEEIYGAVLFERGKRSVQLTNAGQYLKSEVDILLNQLDNIKTQIKKRAEGKITELSIGFIGSAAQSIMPDLLYQLDQEHPLIEVAMNELPNNTQVEYLLHNKLDFGFVRMDTPISGLVLKKITEEPFSLVIPKNYPIQQDNFHSLQQFRNEAFILFSRDYSNAYYELVMSIFGDHGFVPNVHHKTVNALSIFKLVEKGMGVAIVPSSLRIGYDVPVNFIELHDIPQRSQLSLIWNPKNRNPGIPALLSVLEHYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJY9</accession>
    <name>D7VJY9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glu/Leu/Phe/Val dehydrogenase, dimerization domain protein</fullName>
            <ecNumber evidence="5">1.4.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ldh</name>
        <name evidence="5" type="ORF">HMPREF0766_11308</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.9" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998759.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11308"/>
    <dbReference type="EnsemblBacteria" id="EFK58591">
        <property type="protein sequence ID" value="EFK58591"/>
        <property type="gene ID" value="HMPREF0766_11308"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_0_0_10"/>
    <dbReference type="OrthoDB" id="1184827at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050049">
        <property type="term" value="F:leucine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016211">
        <property type="entry name" value="Glu/Phe/Leu/Val_DH_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42722">
        <property type="entry name" value="PTHR42722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000188">
        <property type="entry name" value="Phe_leu_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="4">
        <location>
            <begin position="149"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="185"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000188-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="357" mass="38938" checksum="D6EE30FE2F838E6C" modified="2010-10-05" version="1">MQNSNASLFEMMGQFGHQNLLFCNDEAVGLKAIVAIHDTTLGPAIGGVRMLPYNTTEEAIEDALRLSKAITYKAAVAGLNLGGGSAIIIGNHRTDKTEILLRRLGQFVEGLNGNFIASIDVGTTQKDLEYIHTETNYVAGLPESLNGGGDTTIFAARGVFYGIKAAIKELYGDDSLAGRKVAVQGVGSVGEHLVAMLRNENARVYVSDMTEERKMKIAAKYKAEPITDSTSFEMDVDVYAPCALGGTVNTETVPRMRCKIIAGSANNQLKNEQETTRMLKEHDILYVPDFLINSGALISCYSELEGYGSERTESLIRNIYTITREVIQKSKEESITTLVAANQIAEQRIADVKKIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK30</accession>
    <name>D7VK30_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998876.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11349"/>
    <dbReference type="EnsemblBacteria" id="EFK58632">
        <property type="protein sequence ID" value="EFK58632"/>
        <property type="gene ID" value="HMPREF0766_11349"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031BRY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107595_0_0_10"/>
    <dbReference type="OrthoDB" id="1577514at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="224" mass="24776" checksum="99787327745E4434" modified="2010-10-05" version="1">MLRRIVSCIILFVVSLSLTGCLDIVEEIDLKSNGSGSIQATLNLSKSKTKASSLMMLDQVNGIKIPSKSKIQTEINTIVKLLKQTPGISNVSSKVDFTNFIASIKCDFTDVKALNAFTTTLSNHFKVKVSGHTSYAFDSNKKAFTRNYKFSPEGKKEFGKLNAENQNAFKDAYYTSIYRFTDPVKNQENTSAKVSPNKKAVMLKTGIVNLINGQIDLSNRIQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK36</accession>
    <name>D7VK36_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998892.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11355"/>
    <dbReference type="EnsemblBacteria" id="EFK58638">
        <property type="protein sequence ID" value="EFK58638"/>
        <property type="gene ID" value="HMPREF0766_11355"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_29_4_10"/>
    <dbReference type="OrthoDB" id="2088692at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="90" mass="10586" checksum="B4CF3870BE001F3D" modified="2010-10-05" version="1">MAEQYIDRETLRVIRHNLWKIAKAKEITLEDIEDRTGFSYSQVYRIMRGDNNMSVSGLVAICRALEIQPAQIFDFKLHIPSHLPTRKNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKA8</accession>
    <name>D7VKA8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, NAD-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999080.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11427"/>
    <dbReference type="EnsemblBacteria" id="EFK58710">
        <property type="protein sequence ID" value="EFK58710"/>
        <property type="gene ID" value="HMPREF0766_11427"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065109_0_0_10"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="35"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="331" mass="35859" checksum="172FBD7E0DFF0971" modified="2010-10-05" version="1">MNTSGRREFIRTGSAVLGAMMIHQLLSATAVKGKRIGIIGLDTSHAVAFTRAINTNPAAYRDYHVVAAYPYGTKTIPSATDRIPKYIEEVKSHGVAIVNSIAELLKRVDAVLLETNDGRLHLEQATQVLKAGKPVFIDKPIAASYADAYKIMKLSRQYNTPMFSTSSLRYIGGMEEITGGTYGKVLAADVFTPATLESTHPDFFWYGIHGVEMLFAAMGTGCKSVSRVHTTDSDLIVGVWEGGRIGTVRGMRIGKNDFGGIIFCEQENVKLGEFKGYEPLLHKIVDFFDSGEPPVDGAQTLEICAFIEAADISKNNNGKAVELSGISAVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKR7</accession>
    <name>D7VKR7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinase, PfkB family</fullName>
            <ecNumber evidence="4">2.7.1.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ydjH</name>
        <name evidence="4" type="ORF">HMPREF0766_11586</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999463.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11586"/>
    <dbReference type="EnsemblBacteria" id="EFK58869">
        <property type="protein sequence ID" value="EFK58869"/>
        <property type="gene ID" value="HMPREF0766_11586"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065902_2_1_10"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="3"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="306" mass="33713" checksum="FD04231D38B05735" modified="2010-10-05" version="1">MSLVIIGTVAYDAIETPFGKTDKIVGGAATFAGMAASYLYDHVKLISVIGEDFGDTNLNLLKDKGIDTEGIQIIKGGKSFFWSGKYHNDMNSRDTLATELNVLADFDPIVPEKYQDCEYLLLGNLTPQVQLTTLERLNHTPKLVVLDTMNFWMDVALDDLKAVLKKVDVLTINDEEARQLSGEYALVKAAEVILNMGPKYLIIKKGEHGALLFGENQVFYAPALPLAEVFDPTGAGDTFAGGFVGYLAKVNTVNFNNMKNAIIYGSALASFCVERFGTERLQNLTQEDISKRIQQFIALSKFEISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKS9</accession>
    <name>D7VKS9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative CDP-diacylglycerol-serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="3">2.7.8.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pssA</name>
        <name evidence="3" type="ORF">HMPREF0766_11598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999482.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11598"/>
    <dbReference type="EnsemblBacteria" id="EFK58881">
        <property type="protein sequence ID" value="EFK58881"/>
        <property type="gene ID" value="HMPREF0766_11598"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049944_3_0_10"/>
    <dbReference type="OrthoDB" id="1232102at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="237" mass="26992" checksum="FF81C61B1B6AF9E9" modified="2010-10-05" version="1">MAFLVIYYMKKYIPNTLTCLNLFSGCVGVLFALKGEFQYTFYCVLFSGICDFFDGMAARALHVKSTIGKELDSLADMISFGFLPGAVIYFLLKEINTEMSFLPYLAFVMTVFSGLRLAKFNVDERQSTDFIGLNTPMNTFYIISLPFIAQIYPEIIMNNVFLLVTVAVSSTLLVSELRLFSMKLSSLTWKANQFKYLFLILSIVLLGLLKFLAIPFILLAYIVFSIIHFRTLQQDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKT1</accession>
    <name>D7VKT1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose/galactose transporter family protein</fullName>
            <ecNumber evidence="2">1.14.99.36</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.36" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999486.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11600"/>
    <dbReference type="EnsemblBacteria" id="EFK58883">
        <property type="protein sequence ID" value="EFK58883"/>
        <property type="gene ID" value="HMPREF0766_11600"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028452_2_2_10"/>
    <dbReference type="OrthoDB" id="1121832at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="575" mass="62238" checksum="30E77CF64D0C737D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKW0</accession>
    <name>D7VKW0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Antioxidant, AhpC/TSA family</fullName>
            <ecNumber evidence="3">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.15" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11629"/>
    <dbReference type="EnsemblBacteria" id="EFK58233">
        <property type="protein sequence ID" value="EFK58233"/>
        <property type="gene ID" value="HMPREF0766_11629"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_1_1_10"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106996" evidence="1">
        <location>
            <begin position="27"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="327"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="473" mass="54257" checksum="1BA9928FCC519A8C" modified="2010-10-05" version="1">MQLKLNKMKKNIIILFLSVWTILAYAQQKGATITVDVSPLKLDSLRLFKYDYDDIYAKVDKDGKFVYNLTDGLPKEVILVGPQNKMVYVFLENGNRLNIKTNFEQTTYTGEGAENSEVFNHIMNTVEAAKVKIDASKMTAKEFFDILNNTNQIPIDLLNQNKQRITSSFYNYAMTSFSYQKLQDYMWYGYYYILGKKGKFAEESPADLWVLDQQVQYDDQLLGNRVYDALLLYFYPPYLRRKELFLQGKLDSPHELQDAFTDYQMILKYYPEGKVKNEALSKTIVSVLDQAKELSVVKPLLDEHIAKYADDSTAKILREKYAVMDKLSTGKMAPDFTLKSLEGKDVSLRDFRGKVVYIDFWASWCGPCRGEMKHGSPKLHTKFKDNPDVVFLYISLDSKADDWKKAIDEDKIEGIHLLSQATSGVNTPVAKAFNISGIPRYVIIDRDGRIADNDAPRPSQDITQDKINEALAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL04</accession>
    <name>D7VL04_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fumarate hydratase class II</fullName>
            <shortName evidence="2">Fumarase C</shortName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Aerobic fumarase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Iron-independent fumarase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">fumC</name>
        <name evidence="5" type="ORF">HMPREF0766_11673</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999687.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11673"/>
    <dbReference type="EnsemblBacteria" id="EFK58277">
        <property type="protein sequence ID" value="EFK58277"/>
        <property type="gene ID" value="HMPREF0766_11673"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021594_4_1_10"/>
    <dbReference type="OrthoDB" id="734949at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045239">
        <property type="term" value="C:tricarboxylic acid cycle enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="PTHR11444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lyase_1" evidence="3">
        <location>
            <begin position="11"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="4">
        <location>
            <begin position="409"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="140"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="325"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="465" mass="49824" checksum="6444423E8950DDC8" modified="2010-10-05" version="1">MSFRIEKDTMGEVQVPADKYWGAQTERSRNNFKIGPSASMPHEIVAGFAYLKKAAAYANHELGVLPVEKRDAIGAVCDEILAGKLDDQFPLVIWQTGSGTQSNMNVNEVVANRAQVLAGFKIGEGEPVLKANDDVNKSQSSNDTFPTGMHIAAYKAVAEVTIPGVEKLRDTLAKKAEAFKNVVKIGRTHLMDATPLTLGQELSGYVAQLNHGLKALRNTLSHLSELALGGTAVGTGLNTPAGYDVVVAKYIAEFTGLPFVTAENKFEALAAHDAIVETHGALKQLAVALNKIANDIRMLASGPRSGIGEILIPENEPGSSIMPGKVNPTQCEALTMVAAQVMGNDVAITIGGTQGHYELNVFKPLMAANFLQSARLLGDACVSFDEHCASGIEPNYKRIKELVDNSLMLVTALNTKIGYYKSAEIAQTAHKNGTTLKEEAVRLGYVTAEDFDAWVKPEDMVGSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL29</accession>
    <name>D7VL29_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bacteroidetes-specific putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11698"/>
    <dbReference type="EnsemblBacteria" id="EFK58302">
        <property type="protein sequence ID" value="EFK58302"/>
        <property type="gene ID" value="HMPREF0766_11698"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068235_3_0_10"/>
    <dbReference type="OrthoDB" id="671476at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019861">
        <property type="entry name" value="PorP/SprF_Bacteroidetes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11751">
        <property type="entry name" value="PorP_SprF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03519">
        <property type="entry name" value="T9SS_PorP_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="292" mass="32773" checksum="CA3E3E72500FD3C3" modified="2010-10-05" version="1">MNSYQINRYIISCYLTFIILLFSSLGFAQQVPLASGFFTDKYLQNSAKYGISAENSLLLGIRNNVANNHANQNEQLLNLNLNHNTNGFGAGIHNINSGSFKHTSLQASYAHHLLFDNPGHMLSLGTSLSYTSENIDLKKIEGETNDPTLLDFNRRTNKLDLDLGVAYSVSDVDIQLSVNNILAKKTTYFLVNKSRLFSSVSYTIETASRLRFSPQVSYRKLLNDNDVLDLGGAVAFNPNFQLFALYHSNQNITTGMNLNIKKFKFNFAYLKGTSGIQRNTAECLEFALGYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL85</accession>
    <name>D7VL85_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999873.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK58358">
        <property type="protein sequence ID" value="EFK58358"/>
        <property type="gene ID" value="HMPREF0766_11754"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_780552_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107274" evidence="1">
        <location>
            <begin position="22"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="355" mass="38210" checksum="8AF93692B8DC92D9" modified="2010-10-05" version="1">MKKLLILIILAIGLVIESVSAQDDNGNLIYPTNFNVNNDQLVNGRIKFDSAFGANSVGISGTCGMIVSGVYKNYVTKIIAQVVFIDKDGVVKHSAPSMEFYKSNFMVNGVMTQISIAKPFEFNVGRGSMSGGHLELRYKYEFDAAANIPNLTQSGWAPAVTHNKEWFIHNKKYETIDLARTVFTGPNFICTEGVYNIVNPGNLTLENSANIATLNKIADNSYKINRIGNSAGSVTLKAVFQGKTYTKDILVGIPSSLNILSNAGGNMQGGATYGFHLEENYPLTSISWNITGGIILSGQGTNNISVKVDPNPFQTYNNLGISLQYTSDCGNGSGNKTFYIAPSGGTSPIDPGEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL88</accession>
    <name>D7VL88_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999882.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11757"/>
    <dbReference type="EnsemblBacteria" id="EFK58361">
        <property type="protein sequence ID" value="EFK58361"/>
        <property type="gene ID" value="HMPREF0766_11757"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025928_1_0_10"/>
    <dbReference type="OrthoDB" id="319098at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041662">
        <property type="entry name" value="SusD-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12771">
        <property type="entry name" value="SusD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="496" mass="54255" checksum="2BD43A5BFE800BC5" modified="2010-10-05" version="1">MLKFHSNKKNIMRKNIKTLLLAGIIGSVALVSCNKYLDINENPNNPEKSDPSLLLPTVEAALSQVVGNQFQTYGNMWSQYWTQNPSSSQYQTIDQYNMRGTNSDRAWLNLYRGALNNAEIIINTQGPAHAQYRATAYILKAYAFQLATDAFGDVPLSEALKAGDNLNPAYEKQQVVYDSIFNYIDKGVSELKSLNTSIANNPGEQDMLFKGDAQQWIAFANTLKLRAYLRISNVDPAKAEAGIKALYATNPSFVSKDVSIAYTTTGGNENPMYNEMVGLGRVQNVVASGTIINAFKANNDPRQFALFEKIEGQDTIAWIAQGGYRGMNRKLVSPPAAVVGANANIPGSALAPVKLISKAESYFLQAEAALKGWGAGTVQALYESGVRAGFEALGLSSDATAYLASAPDAQLGTGQEAQQKAIITQKYYAMCGFQGFEAWNEWRRTGYPTFFTVSKESIIEAGLFPIRMVYPNSEATTNAKYPGTISVSDPVWWDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL89</accession>
    <name>D7VL89_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_11758</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999887.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11758"/>
    <dbReference type="EnsemblBacteria" id="EFK58362">
        <property type="protein sequence ID" value="EFK58362"/>
        <property type="gene ID" value="HMPREF0766_11758"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_2_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="116"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="444"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="515"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1079" mass="116796" checksum="8D0A03B7EC5E6EEA" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL90</accession>
    <name>D7VL90_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OmpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11759</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999889.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11759"/>
    <dbReference type="EnsemblBacteria" id="EFK58363">
        <property type="protein sequence ID" value="EFK58363"/>
        <property type="gene ID" value="HMPREF0766_11759"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014978_0_0_10"/>
    <dbReference type="OrthoDB" id="583204at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="3">
        <location>
            <begin position="529"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="650" mass="73337" checksum="76B923D74C3AE800" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLB1</accession>
    <name>D7VLB1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glucose/galactose transporter WARNING</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">gluP</name>
        <name evidence="13" type="ORF">HMPREF0766_11780</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Intake of glucose and galactose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999953.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11780"/>
    <dbReference type="EnsemblBacteria" id="EFK58384">
        <property type="protein sequence ID" value="EFK58384"/>
        <property type="gene ID" value="HMPREF0766_11780"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028452_2_2_10"/>
    <dbReference type="OrthoDB" id="1121832at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005354">
        <property type="term" value="F:galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005355">
        <property type="term" value="F:glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005964">
        <property type="entry name" value="Glc/Gal_transptr_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01272">
        <property type="entry name" value="gluP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFK58384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="428" mass="46720" checksum="AA053CDD9F8737A8" modified="2010-10-05" version="1">MEPQKTNQQSTFGPMIICCALFFILGFITWANGTLIPFLKIACNLETDLQAFFVAFASYIAYFFLALPSSWILKKIGFKNGLIVSLVILGLGSLIFIPAADSRSYGLFLTGIFVQGAAMALLQTAVNPYLSIIGPIESAAQRISIAGLFNKGAGITVPIIFGTLFLKDAHQVTEKLAATTDELVKNQILDDLLQRVHAPYIALAVIFVVFAIIIRFAHLPDVEIDKEESSELDASDTHQKQSVFQFPHLFLGSLAIFFCVAVEVMAGDIIGVYGRELKIDSFFVTYATTFTLSCMLVGYVIGIIAIPKYVTQQMALRVCTIVGIIFTLISVLTTGTTSFIFVALLGIANSLMWPAIFPLGIKGLGRFTKVGSAIMIMGIAGGAIWPLVYGYLKDHLHIDFQHAFLYAMVPAYLYILFFAVKGHKAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLF4</accession>
    <name>D7VLF4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000074.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11824"/>
    <dbReference type="EnsemblBacteria" id="EFK58427">
        <property type="protein sequence ID" value="EFK58427"/>
        <property type="gene ID" value="HMPREF0766_11824"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZSFU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1049078_0_0_10"/>
    <dbReference type="OrthoDB" id="1258969at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025510">
        <property type="entry name" value="DUF4397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14344">
        <property type="entry name" value="DUF4397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4397" evidence="1">
        <location>
            <begin position="101"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="287" mass="32242" checksum="10F38E969FA2F25C" modified="2010-10-05" version="1">MSQKNYGFQNLRIEIFEVMKSIKLIICMLGLVSLFGCEKSVKDYGNLEFMTNDDAIVKINMASVYPDDRYMYVKFNDQRVTPLIRAREPYPGGGWNTRGDSRADFLRIKAGNVNVKLGLPKKKDDGTDSLILYETNIMLTAGKRYTLHLADTAANTKSLLTEEDFSVPDSLYARYRFVNLMPNVPAVDLYYGFFSTTAAGQVATQDSLVASNIKFMEMSEYFVLNRSVSRTWKVRPAGAAVTNATVIAFYGNAGTIVNQRTYTAFALGYNGQTSTAMKPYLSFFNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLH0</accession>
    <name>D7VLH0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase domain protein</fullName>
            <ecNumber evidence="2">3.5.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.6" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000120.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11840"/>
    <dbReference type="EnsemblBacteria" id="EFK58443">
        <property type="protein sequence ID" value="EFK58443"/>
        <property type="gene ID" value="HMPREF0766_11840"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073253_1_0_10"/>
    <dbReference type="OrthoDB" id="733552at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="11"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="260" mass="29255" checksum="9C9C1DA693373C99" modified="2010-10-05" version="1">MKYSAIASGSNGNCYYVAKNDSAILVDAGINSKHIHLRMGNLGIQPDTIKAIFITHEHTDHIRGLSVFSKKYNLPVYITEGSYRGSRLHLPSHLVHVIKPDDKVEIGELTVYGIPKYHDAKEPCSFLVSDGQYNIGILTDIGRACDNVRYVIQHADILLLESNYDEEMLRTGRYSYYLKNRISSGWGHISNTVSLEIFNNCRSSRLKHLILTHLSGENNSVELVEQTFAPHCSEIKLSIATRSAETELFDLHALLLKELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLJ3</accession>
    <name>D7VLJ3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA uridine(34) hydroxylase</fullName>
            <ecNumber evidence="1">1.14.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA hydroxylation protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trhO</name>
        <name evidence="3" type="ORF">HMPREF0766_11863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + O2 + uridine(34) in tRNA = 5-hydroxyuridine(34) in tRNA + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:64224"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:13381"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136877"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrhO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000171.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11863"/>
    <dbReference type="EnsemblBacteria" id="EFK58466">
        <property type="protein sequence ID" value="EFK58466"/>
        <property type="gene ID" value="HMPREF0766_11863"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1054">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038878_1_0_10"/>
    <dbReference type="OrthoDB" id="684577at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00469">
        <property type="entry name" value="TrhO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022111">
        <property type="entry name" value="Rhodanese_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020936">
        <property type="entry name" value="TrhO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040503">
        <property type="entry name" value="TRHO_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268">
        <property type="entry name" value="PTHR43268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12368">
        <property type="entry name" value="Rhodanese_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17773">
        <property type="entry name" value="UPF0176_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="128"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="329" mass="37575" checksum="C07306EA2AF55EF4" modified="2010-10-05" version="1">MNSMTYQTLLYYCYSPIENAEQFAADHLEFCNSLGLVGRIIVADEGLNGTISGTEEACKAYMEAIYADGRFNKTEFKIDVVDEPSFIKMHCRYKEEIVHSGLRDPKEIDPNRQTGIHLEPKDFLEMKDQEDVIILDVRSNYEHSVGRFKNAITLDIENFREFPEKIKELEKYKDKKILTYCTGGIKCEKASALLLKEGFEDVYQLHGGIIKYGKEAGGKDFEGKCYVFDNRLTVDVNEVNPTIVSTCKNCGKTTPKMINCANPECNEHFTQCDECGWELEGCCSAECKEHPRKRPYDGTGYYVKVPQPVNLEKISKRKHKNFPPKTTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLK3</accession>
    <name>D7VLK3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Proton-translocating NADH-quinone oxidoreductase, chain L</fullName>
            <ecNumber evidence="10">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nuoL</name>
        <name evidence="10" type="ORF">HMPREF0766_11873</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.5" evidence="10"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000189.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11873"/>
    <dbReference type="EnsemblBacteria" id="EFK58476">
        <property type="protein sequence ID" value="EFK58476"/>
        <property type="gene ID" value="HMPREF0766_11873"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_6_0_10"/>
    <dbReference type="OrthoDB" id="1274678at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="9">
        <location>
            <begin position="72"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="8">
        <location>
            <begin position="140"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK58476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="639" mass="69622" checksum="785A9FD4997B2B70" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLT9</accession>
    <name>D7VLT9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12193"/>
    <dbReference type="EnsemblBacteria" id="EFK58201">
        <property type="protein sequence ID" value="EFK58201"/>
        <property type="gene ID" value="HMPREF0766_12193"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50336NV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1531544_0_0_10"/>
    <dbReference type="OrthoDB" id="2098442at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="167" mass="19787" checksum="1F9E40E2721F628A" modified="2010-10-05" version="1">MWLKICVVLILVLIAYQDFRYRGVTWYFFPLLFLGLSAISIRNYGWSEVFLYSTLNLVFIGLQLLVLQLYFRVKNGHWQWIFDTVLGWGDVVFFIAIAVYFTVWGYFMFFVLSLAFALVMSLLLRMGTKKEITVPLAGWQSVLFLILFVLEHFNYLSLREIILPNFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLU4</accession>
    <name>D7VLU4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RHS repeat-associated core domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12198"/>
    <dbReference type="EnsemblBacteria" id="EFK58206">
        <property type="protein sequence ID" value="EFK58206"/>
        <property type="gene ID" value="HMPREF0766_12198"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2865529_0_0_10"/>
    <dbReference type="OrthoDB" id="1639867at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="74" mass="8356" checksum="34781C4CE7DB75D9" modified="2010-10-05" version="1">MTPVRLLADDPVIGRWNVVDPMADEFEDLSPYNYGVNNPILMIDPDGIAADTVRLQPVDIFKDAPKREPVQGFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLW8</accession>
    <name>D7VLW8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK57973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001061.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11965"/>
    <dbReference type="EnsemblBacteria" id="EFK57973">
        <property type="protein sequence ID" value="EFK57973"/>
        <property type="gene ID" value="HMPREF0766_11965"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="227"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="517"/>
            <end position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1098" mass="121384" checksum="2AF59FB496C7979D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM64</accession>
    <name>D7VM64_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001339.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12061"/>
    <dbReference type="EnsemblBacteria" id="EFK58069">
        <property type="protein sequence ID" value="EFK58069"/>
        <property type="gene ID" value="HMPREF0766_12061"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2909">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040417_0_0_10"/>
    <dbReference type="OrthoDB" id="802902at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="355" mass="41826" checksum="47F744D71A073691" modified="2010-10-05" version="1">MIYTLEIQKLLNKASYLDDKNKDKIKYFLQAIQLADDNQDIEWAYELRMQLMDIEWEHTDRKNFLPTFSWLLNAYDASPDEYDVEELLWKYKWIISEVQSNPEISLAHMNNIMEDFKRRSELEGYNLRAYHSKLLHEAAEQMDVEKSLYLQSQINLFPRDGISDCQACELDSEVLTLLQDNNFEEGLNKAQPILQEQYTCARVPLVTRVNIAYHALINGQHDIAQQYLDRVIQELSEREEDTYLISSLGDFMPVIFALKPESAWNYVEQFIPWTLDTDKSTRFFFARGMAEALSQKQGGETVTLNIPPSHALYRPENTYTVDEIYTYYLDKAKLLAKQFDLRNENNNFTKQIKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM75</accession>
    <name>D7VM75_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001357.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12072"/>
    <dbReference type="EnsemblBacteria" id="EFK58080">
        <property type="protein sequence ID" value="EFK58080"/>
        <property type="gene ID" value="HMPREF0766_12072"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153689_0_0_10"/>
    <dbReference type="OrthoDB" id="1968538at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021857">
        <property type="entry name" value="DUF3467"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11950">
        <property type="entry name" value="DUF3467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="103" mass="11379" checksum="3086A8F547AA0B86" modified="2010-10-05" version="1">MENNNQENQELSIELTEETAEGVYSNLAIITHSSTEFVVDFVRIMPGVPKAKVKSRIILTPEHAKRLLGALQDNINRFEAQNGSIKANDNTLPLNFGTPKGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMA1</accession>
    <name>D7VMA1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001396.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12098"/>
    <dbReference type="EnsemblBacteria" id="EFK58106">
        <property type="protein sequence ID" value="EFK58106"/>
        <property type="gene ID" value="HMPREF0766_12098"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031BPG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1081444_0_0_10"/>
    <dbReference type="OrthoDB" id="1469741at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="52"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="241" mass="27542" checksum="79C9DCE88D0BA8E3" modified="2010-10-05" version="1">MKNLLYILTALLVLASCNKDDYFSDSGVHDPKFNGNMMQYLDSKGQKPQDPFDTLTQIIRYAGMEDNFKNDRLTFFAPPDPTIRKALNYLNVVLYLGGQDTIKSYQEVKPAVWKSILSEYMIKGDFGLNDFRQVDTTALYAFSGQIFETYNETQPINVGAVYHDLNNNGVVIKYAGPRQILLSYVPDYSRPTSSWVNTFVASSNIQPTNGRVHVLNYNRHVFGFLYNRFANLAIEYGIDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMI3</accession>
    <name>D7VMI3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">glmS</name>
        <name evidence="11" type="ORF">HMPREF0766_12180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12180"/>
    <dbReference type="EnsemblBacteria" id="EFK58188">
        <property type="protein sequence ID" value="EFK58188"/>
        <property type="gene ID" value="HMPREF0766_12180"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_5_2_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="18"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="305"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="477"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK58188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="628" mass="69262" checksum="28975085D0ABE779" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMI7</accession>
    <name>D7VMI7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57134">
        <property type="protein sequence ID" value="EFK57134"/>
        <property type="gene ID" value="HMPREF0766_12207"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3030111_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="55" mass="5577" checksum="05A93F498CA1B1D6" modified="2010-10-05" version="1">MLLVSTLTDTSTAFAGIPTGNTIQAQGTCLCQAHNSETNGIGGDNKKAGVNYSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMJ1</accession>
    <name>D7VMJ1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1080 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992615.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12211"/>
    <dbReference type="EnsemblBacteria" id="EFK57138">
        <property type="protein sequence ID" value="EFK57138"/>
        <property type="gene ID" value="HMPREF0766_12211"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7HW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073042_1_1_10"/>
    <dbReference type="OrthoDB" id="1452706at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107056" description="DUF1080 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1080" evidence="2">
        <location>
            <begin position="32"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="283" mass="31930" checksum="4258D51860D26F7D" modified="2010-10-05" version="1">MKLKNAFAALSIGVLLFSSAPLAAQTVKTPKPIQLFNGKDMKNWIIKIRQHEVGDNYANTFRVEDGLLKVRYDGYKSFDKQYGHIAYDKPFSAYVLRVQYRFVGEQAPEGEGWAWRNSGAMLHGQDPRTMLKNQDFPISIEGQLLGGDGKNERTTSNLCTPGTNVVMNEKLFTPHCISSKSKTYHGDQWVTADFVVLGDSVIQHILEGQVVLEYNKPQIGGGSVSDYDPAQKKDGQLLKQGYISLQSESHPIDFKKVELYNLEPYMKDPKKLDKIVQQIIKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMT4</accession>
    <name>D7VMT4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rplL</name>
        <name evidence="7" type="ORF">HMPREF0766_12304</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992785.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12304"/>
    <dbReference type="EnsemblBacteria" id="EFK57231">
        <property type="protein sequence ID" value="EFK57231"/>
        <property type="gene ID" value="HMPREF0766_12304"/>
    </dbReference>
    <dbReference type="GeneID" id="66690914"/>
    <dbReference type="eggNOG" id="COG0222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086499_3_1_10"/>
    <dbReference type="OrthoDB" id="1822695at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="6">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="5">
        <location>
            <begin position="59"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="125" mass="12890" checksum="9AD0C02FF84EBB68" modified="2010-10-05" version="1">MADLKQLAEQLVNLTVKEVKELADILKDEYGIEPAAAAVAVAAAPAEGGAAAAEEKTSFDVILKEAGGQKLAVVKLVKDLAGLGLKEAKDLVDGAPKELKAGVSKDEAEALKKQLEEAGAVVEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMW5</accession>
    <name>D7VMW5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57262">
        <property type="protein sequence ID" value="EFK57262"/>
        <property type="gene ID" value="HMPREF0766_12335"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4891">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069867_4_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107448" evidence="1">
        <location>
            <begin position="20"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="159" mass="18141" checksum="D1E18A4099470E01" modified="2010-10-05" version="1">MKRIFLVSAILLISLPLMAKEIKTEIVIHATPEKIWKILTDFENYAQWNSFITSITGEVEEGNKIVVRIKPPNGKGMTFKPTILTKTDNKELSWRGKLLFKGLFDGTHIFELINNGDGTTTFIQSEKFSGIFVCLFNPQKTRNGFNEMNKKLKEIAESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMX0</accession>
    <name>D7VMX0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992846.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12340"/>
    <dbReference type="EnsemblBacteria" id="EFK57267">
        <property type="protein sequence ID" value="EFK57267"/>
        <property type="gene ID" value="HMPREF0766_12340"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9MN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_789461_0_0_10"/>
    <dbReference type="OrthoDB" id="937786at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="364" mass="42109" checksum="4BB5E630F08A947E" modified="2010-10-05" version="1">MKNIDNINAFKTTIQETDFGVITRLVADVEVSAKDSILFGAKTLMTNYVYNENGTYNLIYTIIDTDGVTESFAEDNGILPTLFLSPQGDNYVSLVPYDPDKELEISIPVFNRENTEFPKGNRPFKGDFIGISAQFSIFYDVDIWSDTKPDKMLAVEFKDDTIKKKHNIKVPLPRNNKIFIENNEIHLLAKDEDRWLHRQIDEKGNVIRQRRIETKQRYFREILSLSFDRNSYLLIQTKGKIIVEVIDQSGAGETVELMDITDPFFNTWQPVKVSENTFVTRFNGEFGNGWFTTRNDRLLEIFYSKGEKGYKNMLTNEVLQMDDENLVISGLNKTDDNSYAVVFYPMTDRTTKNKTLLILNRKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN00</accession>
    <name>D7VN00_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein</fullName>
            <ecNumber evidence="3">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">zraS</name>
        <name evidence="3" type="ORF">HMPREF0766_12370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992893.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12370"/>
    <dbReference type="EnsemblBacteria" id="EFK57297">
        <property type="protein sequence ID" value="EFK57297"/>
        <property type="gene ID" value="HMPREF0766_12370"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029850_0_0_10"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011623">
        <property type="entry name" value="7TMR_DISM_rcpt_extracell_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011622">
        <property type="entry name" value="7TMR_DISM_rcpt_extracell_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07695">
        <property type="entry name" value="7TMR-DISM_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07696">
        <property type="entry name" value="7TMR-DISMED2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="437"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="625" mass="71964" checksum="4C284F5B99DB51B3" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNB5</accession>
    <name>D7VNB5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993042.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12485"/>
    <dbReference type="EnsemblBacteria" id="EFK57412">
        <property type="protein sequence ID" value="EFK57412"/>
        <property type="gene ID" value="HMPREF0766_12485"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZC64">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046825_3_0_10"/>
    <dbReference type="OrthoDB" id="1802360at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022134">
        <property type="entry name" value="DUF3667"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12412">
        <property type="entry name" value="DUF3667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="240" mass="27354" checksum="426C48003E2E6F08" modified="2010-10-05" version="1">MAENCRSCNALITGNYCSDCGQKVKLDRINGHYIKHEIEHVLHFEKGILYTIKALLRHPGASVREFISENRNRLVKPIIFIVITSLIYSLTAHFFHIEEGYINIAYAKKASTVNYLNQWVQGHYGYANLIMGIFIAAWIRLFFRKYDVNFYEIIILLCFVMGIEMLFCALFALLEGVTHLPLAPVASVIVLIYTTWGIGNFFGKKVANYLKAFFGYVLGTVSFSLAILIIGTMVDLLLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNU6</accession>
    <name>D7VNU6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RteC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993297.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12666"/>
    <dbReference type="EnsemblBacteria" id="EFK57593">
        <property type="protein sequence ID" value="EFK57593"/>
        <property type="gene ID" value="HMPREF0766_12666"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9CP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079317_0_0_10"/>
    <dbReference type="OrthoDB" id="694160at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018534">
        <property type="entry name" value="Tet_reg_excision_RteC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09357">
        <property type="entry name" value="RteC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="281" mass="33149" checksum="D8910F747464FEB7" modified="2010-10-05" version="1">MQHSLHTIILEIHNKEDKILSQSKRLIDEAYEMTLYLQDLLFEVKKYIAKKGFQNDGEEIKFFRTIKPQILGKLIYYNKIYRIETTCPVSNGKMYYSYFSTQLANLKREYIEHICNSDFYRYYRSGRTDRDDTYFKRGNINYHDGLNSIVFEIDPEFSTFYDYKTARIIANELLYTYLLTKINPDENPDAILQKPENAKDIFWTESKNALVELIYALYASAAVSHGKTGVRKISLMFQILFGITLGDLHHAFHRMKTRSGSRTAFLDQLKTSLEEYMDKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP32</accession>
    <name>D7VP32_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12752"/>
    <dbReference type="EnsemblBacteria" id="EFK57679">
        <property type="protein sequence ID" value="EFK57679"/>
        <property type="gene ID" value="HMPREF0766_12752"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3222224_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="44" mass="5290" checksum="BBE87504BE9BC57F" modified="2010-10-05" version="1">MIRTVAAILRGQLYFNSNLFFYNDQENVKSNHIRIMNLEKFNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPB1</accession>
    <name>D7VPB1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993589.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12831"/>
    <dbReference type="EnsemblBacteria" id="EFK57758">
        <property type="protein sequence ID" value="EFK57758"/>
        <property type="gene ID" value="HMPREF0766_12831"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1119607_0_0_10"/>
    <dbReference type="OrthoDB" id="1168100at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="248" mass="27887" checksum="95AB0A210FEB501A" modified="2010-10-05" version="1">MSTIHLFNDHKNQPNGNNLGDLEKTVIINSLMQTPIAQRDGAWVEAFVTNVAEANLTLSEPEVMMGSDGFPYFNLRTIESNQDFKAFVIANQLDYILGQGFGVAINAGAEQSDWIFSYGDLTNLKLNGEFYTDESIFSPQNGSAVIGKDEEILVGQPSESILPAQLRANIREYLVYNGIKNPKIALIARDYKNEETVKQDLVFNIIPKQFATEKEFEAIMTTIVWFLPRHYSFMGLDEMSIENGFQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPD2</accession>
    <name>D7VPD2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridine nucleotide-disulfide oxidoreductase</fullName>
            <ecNumber evidence="4">1.6.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ndh</name>
        <name evidence="4" type="ORF">HMPREF0766_12852</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.3" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993621.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12852"/>
    <dbReference type="EnsemblBacteria" id="EFK57779">
        <property type="protein sequence ID" value="EFK57779"/>
        <property type="gene ID" value="HMPREF0766_12852"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_7_1_10"/>
    <dbReference type="OrthoDB" id="403436at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="12"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="436" mass="48763" checksum="A3A0FF930CF8AC32" modified="2010-10-05" version="1">MLSSRSERSFPRVIVIGGGFGGVEVAKHLKNKDVEVLLLDRNNYHTFQPLLYQVATGTLAADAISFPLRKMFKSQENFKFRIAEVSHIDTDTKIVRTDVGDFDYDYLVVATGATTNFFGNQEVAKYSLPMKSIREALNIRSYVLQNLEAAVLRETATQRAPYLNFVVVGGGPTGVELSGAIAEIRNNILRKDYPELSTQEMNVYLIEGQDKILAALSPQASEKAETYLKELGVKVLLNKQVTGYNGNTISFSDGESIDTKTVIWGAGVMGQFPEGLEKDIIQRGNRIKTDATCRVEGLENVFAIGDVSAMITKDLPRGLPGVAPVAQQQGKFVAHQIMHLLNDQPLENFSYFDKGSMATIGRNRAVVDMGKIRFQGFFAWFVWMFVHLMSIFGFRNKLVTFVNWSIKFFTMNGGIRLIINKYERPKPEEKKPALTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPJ5</accession>
    <name>D7VPJ5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_12915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993761.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12915"/>
    <dbReference type="EnsemblBacteria" id="EFK57842">
        <property type="protein sequence ID" value="EFK57842"/>
        <property type="gene ID" value="HMPREF0766_12915"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_307117_0_0_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107409" evidence="5">
        <location>
            <begin position="22"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="124"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="385"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK57842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="957" mass="105944" checksum="F2A0D1C6B55EF088" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPK2</accession>
    <name>D7VPK2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SelT/selW/selH selenodomain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993776.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12922"/>
    <dbReference type="EnsemblBacteria" id="EFK57849">
        <property type="protein sequence ID" value="EFK57849"/>
        <property type="gene ID" value="HMPREF0766_12922"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068510_3_1_10"/>
    <dbReference type="OrthoDB" id="1921670at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="112" mass="13006" checksum="DD04429D20DAC112" modified="2010-10-05" version="1">MRIQIHKLVKDNDTIFEMKPTITIEYCPKCGWMLRAAYMAQELLTTFTEELNGVTLKPSELSGRYLITIDKTEIFDRKRMGRFPEIKELKQLVRDIVAADKDLGHSDRKSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPM3</accession>
    <name>D7VPM3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993799.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12943"/>
    <dbReference type="EnsemblBacteria" id="EFK57870">
        <property type="protein sequence ID" value="EFK57870"/>
        <property type="gene ID" value="HMPREF0766_12943"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_17_2_10"/>
    <dbReference type="OrthoDB" id="2051456at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="7"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="147" mass="16713" checksum="34F765662EB46972" modified="2010-10-05" version="1">MALLHAYLNFNGNCEEAFEFYKGVFGTESLGIYRFGDMPADPEYPIQDEDKNKIMHTAIKINESVMLMGSDCIQNFGHSATTGTNAYLMLDTQTAEEAQQLYSRLSAEAQSIEMPLGEQFWAELYSSFQDKYGISWMIHFEGNKKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPM4</accession>
    <name>D7VPM4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12944"/>
    <dbReference type="EnsemblBacteria" id="EFK57871">
        <property type="protein sequence ID" value="EFK57871"/>
        <property type="gene ID" value="HMPREF0766_12944"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147287_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="30"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="137" mass="15643" checksum="F2F4D2BA0F704FD7" modified="2010-10-05" version="1">MPDGLILPVETDKKLYRTNSSPMSNAKQVVEQYMQGFRESDHNKVLECLTEDVIWHMPGYFHLQGKEAFDKEIENDLFTGSPSIQVFRMIEEGTVVIAEGAVQGKFKTGDLLDAVFCDVFEFEGLKIKKLISYQMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPX0</accession>
    <name>D7VPX0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14330"/>
    <dbReference type="EnsemblBacteria" id="EFK57127">
        <property type="protein sequence ID" value="EFK57127"/>
        <property type="gene ID" value="HMPREF0766_14330"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZC7A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014083_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="674" mass="77523" checksum="CFCDCCFC783C8A27" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ43</accession>
    <name>D7VQ43_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase, S9A/B/C family, catalytic domain protein</fullName>
            <ecNumber evidence="5">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_13097</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13097"/>
    <dbReference type="ESTHER" id="9sphi-d7vq43">
        <property type="family name" value="Glutamyl_Peptidase_S9"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.021"/>
    <dbReference type="EnsemblBacteria" id="EFK55894">
        <property type="protein sequence ID" value="EFK55894"/>
        <property type="gene ID" value="HMPREF0766_13097"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017120_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107514" evidence="3">
        <location>
            <begin position="29"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="4">
        <location>
            <begin position="655"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK55894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="809" mass="92056" checksum="26F4917F8DF22D40" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ94</accession>
    <name>D7VQ94_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptidase family M13</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pepO</name>
        <name evidence="11" type="ORF">HMPREF0766_13148</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994109.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13148"/>
    <dbReference type="EnsemblBacteria" id="EFK55945">
        <property type="protein sequence ID" value="EFK55945"/>
        <property type="gene ID" value="HMPREF0766_13148"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3590">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006187_7_2_10"/>
    <dbReference type="OrthoDB" id="305005at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="PTHR11733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107142" evidence="8">
        <location>
            <begin position="20"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M13_N" evidence="10">
        <location>
            <begin position="36"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M13" evidence="9">
        <location>
            <begin position="462"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK55945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="667" mass="75375" checksum="A1EABB553A146413" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQB5</accession>
    <name>D7VQB5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_13169</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994162.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13169"/>
    <dbReference type="EnsemblBacteria" id="EFK55966">
        <property type="protein sequence ID" value="EFK55966"/>
        <property type="gene ID" value="HMPREF0766_13169"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_2_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107794" evidence="5">
        <location>
            <begin position="21"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="114"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="426"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK55966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1018" mass="110522" checksum="D37620A575A6BEEC" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQN4</accession>
    <name>D7VQN4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-70 region 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_13288</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994400.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13288"/>
    <dbReference type="EnsemblBacteria" id="EFK56085">
        <property type="protein sequence ID" value="EFK56085"/>
        <property type="gene ID" value="HMPREF0766_13288"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_9_3_10"/>
    <dbReference type="OrthoDB" id="1992113at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="130"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK56085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="185" mass="21358" checksum="EB1B19B8B70FADDD" modified="2010-10-05" version="1">MNNANNTSEEQLIASLQSKDEKAFNYLYDNYAGALYGVIIRIVNSKEYADEVIQDIFVKIWNNIHSFDAGKGRLYTWMINIARNTAIDYIKSKSVQNEQKNQSLPNIVDDKEINNFAVAENVDHIGFKNVLNELKADWRELIEMAYFEGYTQNEIAVKLDIPLGTVKTRTRGALIELRRLLKDYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQN7</accession>
    <name>D7VQN7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG2</name>
        <name evidence="1" type="ORF">HMPREF0766_13291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13291"/>
    <dbReference type="EnsemblBacteria" id="EFK56088">
        <property type="protein sequence ID" value="EFK56088"/>
        <property type="gene ID" value="HMPREF0766_13291"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="256" mass="27901" checksum="EC20289B141651FE" modified="2010-10-05" version="1">MNKMKQQNIALVTGGSRGLGKEMVLRLAQKGIDIILTYNSKHDEAQEVVEQVNLLGQRAVAIQLNVADTASFEDFFGKVKHVLKDTFETDRFDYLINNAGIGIHKSFVDTTEEDFDTLLNIQFKGVFFLTQKALPLMNDGGSVINISTGLARFSFPGYAAYASMKGAVETLTKYLAKELGERRIRVNVVAPGAIETDFGGGAVRDNENMNKTIASVTALGRAGVPEDIGGVVAFLCTEEARWINAQRIEVSGGMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQX5</accession>
    <name>D7VQX5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lanR</name>
        <name evidence="2" type="ORF">HMPREF0766_13379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994517.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13379"/>
    <dbReference type="EnsemblBacteria" id="EFK56176">
        <property type="protein sequence ID" value="EFK56176"/>
        <property type="gene ID" value="HMPREF0766_13379"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_44_1_10"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="69" mass="7854" checksum="E5F7403877293DB1" modified="2010-10-05" version="1">MTNTLKVERARRNMTQAELATLVEVSRQTINSIEIGKYVPSTLLALKIAAVFEISIESLFNLEESDWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR68</accession>
    <name>D7VR68_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Riboflavin biosynthesis protein RibD C-terminal domain protein</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994638.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13472"/>
    <dbReference type="EnsemblBacteria" id="EFK56269">
        <property type="protein sequence ID" value="EFK56269"/>
        <property type="gene ID" value="HMPREF0766_13472"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_4_3_10"/>
    <dbReference type="OrthoDB" id="1306955at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="10"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="187" mass="21086" checksum="5E94AEF9E98C11FF" modified="2010-10-05" version="1">MLSVLMNMKKIILDLAVTLDGFIEGPNGEVDWCIMDEDMDFAGFMSGIDTIFYGRVSYDAWGNYQPETSADPVEKQLWNDIHSKQKFVFSSQTRADEHATFIPSDVAQRVSEIKAQGGKDIWLYGGASLIRSFIQLGLIDIYRISVHPVALGSGKPLFENLKDRVQLNLIRTNTFKSGVVQLIYEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR86</accession>
    <name>D7VR86_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994663.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13490"/>
    <dbReference type="EnsemblBacteria" id="EFK56287">
        <property type="protein sequence ID" value="EFK56287"/>
        <property type="gene ID" value="HMPREF0766_13490"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033APV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2318668_0_0_10"/>
    <dbReference type="OrthoDB" id="1878772at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021309">
        <property type="entry name" value="DUF2892"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11127">
        <property type="entry name" value="DUF2892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="99" mass="10522" checksum="7D6E3B437183D2AD" modified="2010-10-05" version="1">MSNILNLALEKVKDKLDTGCVDGNVGNSERVLSVVAGGFILGIGIRNIFKSPLTGFSTLTLGGALVWRGVTGKCVVKDTIAKATGEQDVTVIEHRYFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRD3</accession>
    <name>D7VRD3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YceI-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994722.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56334">
        <property type="protein sequence ID" value="EFK56334"/>
        <property type="gene ID" value="HMPREF0766_13537"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071003_3_0_10"/>
    <dbReference type="OrthoDB" id="1767227at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="4"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="175" mass="19223" checksum="16F14F2596D93580" modified="2010-10-05" version="1">MATIWNLDSAHSELEFKVKHMMISNVKGLFQDFEIELEGNGEDLTSATIKAAIKTDSINTKNEQRDQHLKSGDFFDAANYPEIKFVSTSIVKKSEDEFAVTGDLTIKDVTKPITLDVDFGGIAVDPWGNSKAGYTFSGKINRSDFGLTWNAALETGGVMVSEEVKISGDIQFSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRG6</accession>
    <name>D7VRG6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994762.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56367">
        <property type="protein sequence ID" value="EFK56367"/>
        <property type="gene ID" value="HMPREF0766_13570"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030CG4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1234369_0_0_10"/>
    <dbReference type="OrthoDB" id="1746752at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="224" mass="25893" checksum="AB15D22E5972DD64" modified="2010-10-05" version="1">MKNIYYLLFSLSLLACNARPVEDKTNIHSDTTNIAKDSLQAPVVKDEPEQTAEQKFLWREDQYDDELKDTFNMIRIDEDLAKNLSDSERAAIGYVATFIGNECQWDGPYKDDRSNLKCKILTALQLGYQCSEQHIGFLKKWFKDDKVVLEELQGCPTIPDGATIQNTFDEISFKKEGDKLTVNFIVSGHNMREGKSWKWVETDYFQINGNTIKYIKKDKRKVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRI4</accession>
    <name>D7VRI4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TIGR01777 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13588</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994784.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13588"/>
    <dbReference type="EnsemblBacteria" id="EFK56385">
        <property type="protein sequence ID" value="EFK56385"/>
        <property type="gene ID" value="HMPREF0766_13588"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047373_0_3_10"/>
    <dbReference type="OrthoDB" id="1566711at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="3">
        <location>
            <begin position="252"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="299" mass="34117" checksum="2A4D495BD52A43CB" modified="2010-10-05" version="1">MKEIVLISGANGLVAKHLTTLLRNKYELRYLTRHKKTANEYEWDIEQHRIDEQAFDQVAHIIHLAGANIFDKRWTSKQKHNLRSSRIDSAQLIFDTLKKRNQQIKTFISGSASGYYGMVTSDHVFKESDSPGNDFLADLTKDWEAKADQFENEGLAERVVKIRTSIVLAKDGGALPLLKRVTNLYLNTALGNGKQYFPWIHIDDITGIIAFALDHQHVNGPVNAVASEHVNNRDFTYKLAQHLHKRIILPAVPEFILKTILGEQADMILKGSRLSNDRIRQLGYEFKFPTLDRALEDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRR0</accession>
    <name>D7VRR0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994950.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13664"/>
    <dbReference type="EnsemblBacteria" id="EFK56461">
        <property type="protein sequence ID" value="EFK56461"/>
        <property type="gene ID" value="HMPREF0766_13664"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052345_4_0_10"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="223"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="320" mass="37830" checksum="EC50CF83D17AE806" modified="2010-10-05" version="1">MLIKSKIEELDEWLFIEEIPDLYIPDKPLVEKRVEIKRDPITMTNFQLSTSGLFILHTNMRFDQPVHIYTEVEGEVITSQFIFYKSIDSKSQYGMSRHNIRYIPTVKSSHEVKTGVDYSYFIAVISKEYYLNLIKRDSLLHRDFVKNIEKGHYTSFAEEDLMATYEMQHTIDELLTSKKTGEIRRLHTESRIVELLMYQFEQYNEQGTPNNELFNEDDIYRLEMARQILEQRIANPPTQKELASEVMMSESKLRKDFKEYFSVTIHDYLTRVRMEKARILLLAKQMTVYEVALLTGFGHQNNFSSAFKKYYGISPGELKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRX2</accession>
    <name>D7VRX2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cysN</name>
        <name evidence="8" type="ORF">HMPREF0766_13726</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13726"/>
    <dbReference type="EnsemblBacteria" id="EFK56523">
        <property type="protein sequence ID" value="EFK56523"/>
        <property type="gene ID" value="HMPREF0766_13726"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2895">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_5_2_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04166">
        <property type="entry name" value="CysN_ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03695">
        <property type="entry name" value="CysN_NodQ_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04095">
        <property type="entry name" value="CysN_NoDQ_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041757">
        <property type="entry name" value="CysN_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044138">
        <property type="entry name" value="CysN_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044139">
        <property type="entry name" value="CysN_NoDQ_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011779">
        <property type="entry name" value="SO4_adenylTrfase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02034">
        <property type="entry name" value="CysN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="43"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK56523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="456" mass="51600" checksum="938BA43039A6E55C" modified="2010-10-05" version="1">MTKSPRQQWKTVRKQDIFKEIKDRLVVISGEINYSNLKQTTKMNILKFITAGSVDDGKSTLIGRLLYDTDSILDDQLEAIQKANRKNDDGTVDLAILTDGLKAEREQGITIDVAYKYFQTENRKFIIADAPGHIQYTRNMVTGASNSDLIIVLIDARKGVIEQTKRHSFLAKLLSLKKVLVCVNKMDMVDYEQAVFENIKHDYEQLAQKLGLTHVDYLPVSALKGDNIVHKSTRMNWYEGPSLLDYLESVEFEENTNENWRFPVQWIVRPQTDELHDYRGYAGRVVGEGLSVDDKVLILPSGTESSIKAIELNGKHLEKAENGQSVIVHLADDVDISRGDVIVSAENPALAERQFEANICWFDNKPLDTAQVYLIQYHSKLTKVKIQDVLHKIDINTQEYLYNEPIKLNDIGKVEVKAAEDIIFDRASDNPANARAILIDPRTNLTVGALIIENVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSB6</accession>
    <name>D7VSB6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA/RNA non-specific endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_13870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995470.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13870"/>
    <dbReference type="EnsemblBacteria" id="EFK56667">
        <property type="protein sequence ID" value="EFK56667"/>
        <property type="gene ID" value="HMPREF0766_13870"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1864">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_518606_0_0_10"/>
    <dbReference type="OrthoDB" id="1230356at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="Extracellular_endonuc_su_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025049">
        <property type="entry name" value="Mfa-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042278">
        <property type="entry name" value="Mfa-like_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="PTHR13966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13149">
        <property type="entry name" value="Mfa_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease_NS" evidence="7">
        <location>
            <begin position="305"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="NUC" evidence="6">
        <location>
            <begin position="306"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK56667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="524" mass="58311" checksum="A47A7259C34B22BC" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSC4</accession>
    <name>D7VSC4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ricin-type beta-trefoil lectin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13878</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995484.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13878"/>
    <dbReference type="EnsemblBacteria" id="EFK56675">
        <property type="protein sequence ID" value="EFK56675"/>
        <property type="gene ID" value="HMPREF0766_13878"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3867">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3979">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_440677_0_0_10"/>
    <dbReference type="OrthoDB" id="324607at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035423">
        <property type="entry name" value="M60-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042279">
        <property type="entry name" value="Pep_M60_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031161">
        <property type="entry name" value="Peptidase_M60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17291">
        <property type="entry name" value="M60-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13402">
        <property type="entry name" value="Peptidase_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01276">
        <property type="entry name" value="M60-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51723">
        <property type="entry name" value="PEPTIDASE_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107320" evidence="1">
        <location>
            <begin position="25"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M60" evidence="3">
        <location>
            <begin position="88"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="477"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="622" mass="68471" checksum="3E40555A08F32136" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSM0</accession>
    <name>D7VSM0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13974"/>
    <dbReference type="EnsemblBacteria" id="EFK56771">
        <property type="protein sequence ID" value="EFK56771"/>
        <property type="gene ID" value="HMPREF0766_13974"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110690_0_0_10"/>
    <dbReference type="OrthoDB" id="1798904at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025365">
        <property type="entry name" value="DUF4269"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14091">
        <property type="entry name" value="DUF4269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="174" mass="20471" checksum="B1177D1BD500D978" modified="2010-10-05" version="1">MDFTTIHYLQYGNHVQQEIYQLLQKHRIFDLLAVYHPILAGTYPIAINIESSDLDIICEVQDLQSFQELLKKEFASREDFSLQHKTIYDEPSVICNFKLDGFEFELFGQNIPTNKQYAYRHMLIEYNLLKTYGDPFRERIIQLKKQGIKTEPAFAQLLGLKGDPYLALLDLEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSQ8</accession>
    <name>D7VSQ8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995723.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14012"/>
    <dbReference type="EnsemblBacteria" id="EFK56809">
        <property type="protein sequence ID" value="EFK56809"/>
        <property type="gene ID" value="HMPREF0766_14012"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5034980">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2371323_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="96" mass="10453" checksum="F3E2EFD947F70EE4" modified="2010-10-05" version="1">MKNKIRFILPRLIGLTVLAGLLALVVGLIFKLLLVGTLLAGAGMFIASRFKKRQAAMIGNERRKGIAPAYYEMSSSAIRPQYSAADSADYAIIPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSS1</accession>
    <name>D7VSS1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MIP family channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glpF</name>
        <name evidence="7" type="ORF">HMPREF0766_14025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995752.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14025"/>
    <dbReference type="EnsemblBacteria" id="EFK56822">
        <property type="protein sequence ID" value="EFK56822"/>
        <property type="gene ID" value="HMPREF0766_14025"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0580">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_9_2_10"/>
    <dbReference type="OrthoDB" id="1744995at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="241" mass="24946" checksum="D9D451357413C8FD" modified="2010-10-05" version="1">MTPFVAELIGTAVLILLGGGVVANVVLNKTKGNNSGWIVITTAWGLAVFCGVVIAGPYSGAHLSPAVTVANMALGKMTFAAGMEYIAAQFAGAMSGAFLVWLMYKDHFDATEDAGAKQAVFCTAPAIRNIPVNLISEIVGTFVLIFTIFHFTDAKLADDSPVGLGSIGALPVAFVVWVIGLALGGTTGYAINPARDLGPRIMHALLPIRNKAGFDAGYAWVPVIGPVIGSLLAVGLYLVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT07</accession>
    <name>D7VT07_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase, C-terminal domain protein</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">acdA</name>
        <name evidence="9" type="ORF">HMPREF0766_14111</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995938.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14111"/>
    <dbReference type="EnsemblBacteria" id="EFK56908">
        <property type="protein sequence ID" value="EFK56908"/>
        <property type="gene ID" value="HMPREF0766_14111"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_3_10"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="124"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="230"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK56908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="389" mass="43573" checksum="C03106A5FFCDA969" modified="2010-10-05" version="1">MQATLLTAEHQTFRETLRAFIRKEILPHIDRWEKDNQIDKSIWKKMGDMGFLGLNYPEAYGGLDLDFYYSMIFCEELSYCYSGGFTISALVIQYMSAPYLLKYASEELKQRYLTGVIAGDLVSAVAITEPGAGSDIQHIKTTAVREGDYYIVNGSKTFITNGYYGDFFITAVKTDPSKKSKGISLLLIDRNTPGVSAHKINKMGWHASDTAELGFDQVKVPVSHLIGEEGAGFGYLMGGLQLERLTAAIQSISTADSALQYTLAYIDKREAFGKKLMDFQVLRHRIAQMVADIATTKAFVYHCCDLQQRGDYAVQECSIAKLQSSELAIKIVHECLQLFGGYGFTEDYKISRLYRDVRVGTIIGGTSEIMREIIAKTAIDKVNYHTKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT11</accession>
    <name>D7VT11_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-methylisocitrate lyase</fullName>
            <shortName evidence="3">2-MIC</shortName>
            <shortName evidence="3">MICL</shortName>
            <ecNumber evidence="3">4.1.3.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">(2R,3S)-2-methylisocitrate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">prpB</name>
        <name evidence="5" type="ORF">HMPREF0766_14115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3 4">Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.30" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995946.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14115"/>
    <dbReference type="EnsemblBacteria" id="EFK56912">
        <property type="protein sequence ID" value="EFK56912"/>
        <property type="gene ID" value="HMPREF0766_14115"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027389_3_2_10"/>
    <dbReference type="OrthoDB" id="1485205at2"/>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01939">
        <property type="entry name" value="PrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012695">
        <property type="entry name" value="PrpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02317">
        <property type="entry name" value="prpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="44"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="122"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="209"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="298" mass="32183" checksum="7275652CC14FC649" modified="2010-10-05" version="1">MINSPGLLFREAIKNEKPLQVVGAINANHALLAQQAGFKAIYLSGGGVAAGSLGVPDLGITNLQDVLIDVERISNVCTLPLMVDIDTGFGPSAFNVARTIRSLVKAGAAAVHMEDQVGAKRCGHRPGKELVSTDEMADRIKAAVDARTDVNFVIGARTDALASEGIDKALDRAVAYKEAGADFIFAEAVHTLEEYTRFSEATGLPVLANITEFGQTPLFTKEELGEAGVAIVLYPLSAFRAANKAAANVYSHIRKDGGQAAVLDTMQTREELYKSINYYEYENRLDQLFNTKYDERNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT15</accession>
    <name>D7VT15_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995956.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14119"/>
    <dbReference type="EnsemblBacteria" id="EFK56916">
        <property type="protein sequence ID" value="EFK56916"/>
        <property type="gene ID" value="HMPREF0766_14119"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_933524_0_0_10"/>
    <dbReference type="OrthoDB" id="710757at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032774">
        <property type="entry name" value="WG_beta_rep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14903">
        <property type="entry name" value="WG_beta_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107551" evidence="1">
        <location>
            <begin position="21"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="298" mass="33633" checksum="6272A47AAB97CCE0" modified="2010-10-05" version="1">MKRINITLAALLVFCTTTFAQSKKMFRIDYSTFSQEEADNSQDNEQEIIFQGWVNKDFIRFYVHGEDPTVQLTNKKTGSSTMLYPGLKQFGTIYGENEAPADHNFDDLDIQYVAGKQKTIAGYTCKLAQINASEDTDGAYSLEIWYTEQIPSIYWGDYEFLKKLPGAALSMSVMGSGFIANKIVQEDVAETLLTIPQDYAEMEEIAEEAVEPESLGEGVYQYTDENTGLYGLRDEEGNVITQPKFTSILHFYEGNAVASDADYNYGTIDPKGNTVIPFNYSFLSFDTNSEQYLFIKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT86</accession>
    <name>D7VT86_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YARHG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996125.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14190"/>
    <dbReference type="EnsemblBacteria" id="EFK56987">
        <property type="protein sequence ID" value="EFK56987"/>
        <property type="gene ID" value="HMPREF0766_14190"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032TPM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1265038_0_0_10"/>
    <dbReference type="OrthoDB" id="1209557at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025582">
        <property type="entry name" value="YARHG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038434">
        <property type="entry name" value="YARHG_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13308">
        <property type="entry name" value="YARHG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01324">
        <property type="entry name" value="YARHG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107360" description="YARHG domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="YARHG" evidence="2">
        <location>
            <begin position="20"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="237" mass="27325" checksum="734F11DE32C49247" modified="2010-10-05" version="1">MKNLLILFLIAFSQYAAAQTLKDCSTCATELIKADQIKELSVDEIRYLMNDLFARKGYVFQSSEIDSYYSDKSWYKPVNANSTLEYNKIENQNIKLFQDRTKALLAERAQLIAELKKLKSLVMSKNKIVLQNQFGYKTEDNNDYMLNVVDEIFLDDIHWFKNEGLYKVSKDNGDIIKEYTLKIVGNTVTFSFSLRGFSDIGNGNTIYPTTFSPESSYIYVFRFAQGKLRFDKVIVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTA6</accession>
    <name>D7VTA6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_14210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996181.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14210"/>
    <dbReference type="EnsemblBacteria" id="EFK57007">
        <property type="protein sequence ID" value="EFK57007"/>
        <property type="gene ID" value="HMPREF0766_14210"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006935_0_0_10"/>
    <dbReference type="OrthoDB" id="173242at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107914" evidence="5">
        <location>
            <begin position="21"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="127"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="456"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK57007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="925" mass="103845" checksum="F9FEF445F2487645" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTD2</accession>
    <name>D7VTD2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PHP domain protein</fullName>
            <ecNumber evidence="3">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996260.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14236"/>
    <dbReference type="EnsemblBacteria" id="EFK57033">
        <property type="protein sequence ID" value="EFK57033"/>
        <property type="gene ID" value="HMPREF0766_14236"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0497">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006611_0_1_10"/>
    <dbReference type="OrthoDB" id="188704at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="2">
        <location>
            <begin position="18"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="542"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="892" mass="101139" checksum="33AA35DFB335316A" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTF8</accession>
    <name>D7VTF8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_14262</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996327.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14262"/>
    <dbReference type="EnsemblBacteria" id="EFK57059">
        <property type="protein sequence ID" value="EFK57059"/>
        <property type="gene ID" value="HMPREF0766_14262"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_10"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="328"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="360"/>
            <end position="367"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="543" mass="61922" checksum="138F54BEB9891795" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTI5</accession>
    <name>D7VTI5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alkaline phosphatase family protein</fullName>
            <ecNumber evidence="7">3.1.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">phoB</name>
        <name evidence="7" type="ORF">HMPREF0766_14289</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14289"/>
    <dbReference type="EnsemblBacteria" id="EFK57086">
        <property type="protein sequence ID" value="EFK57086"/>
        <property type="gene ID" value="HMPREF0766_14289"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1785">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008539_5_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="PTHR11596"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="479" mass="52687" checksum="12076FE35D0A831F" modified="2010-10-05" version="1">MKTDTQIHNMKKLSLLFALSILSFHLAFAQQKPKYIFFMIGDGMGLNQVNLTEMYLAEREGRIGISPLVFTGFPVASFATSYSTSNGVTDSGAGGTALAVGNKTKNGVIGMDSTKTKPLKSIAYLAKEKGMKVGITTSVSIDHATPASFYAHQPDRDMYYEIAQDILQSDFDFFGGSGFLKPEQNFKKEKVTPITQILQKGGYSLVEGYQEYKTLKNKAGKIILSNNKGADQVSLKYAIDQNPNDLTLKQITSAAIESLTEENNNGFFLMVEGGKIDWACHSNDGATAVKEVLDFNEAVKEAFDFYKKYPEETLIIVTADHETGGMTLGTGSSRLSFKNLELQKKSQSELSAQISKLRISNPKTTWDEVKQLLSDQLGLWSVIKVSKADEQNMHETYLRSFVNHETQESKSLYATDDKLATLAVKVLNDASTLGWGSGNHSASYIPIFAIGSGSELFTHKMENTDIPKKVAKLLNAQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTQ6</accession>
    <name>D7VTQ6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001730.1">
        <property type="nucleotide sequence ID" value="NZ_GL379777.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14376"/>
    <dbReference type="EnsemblBacteria" id="EFK55815">
        <property type="protein sequence ID" value="EFK55815"/>
        <property type="gene ID" value="HMPREF0766_14376"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084740_0_0_10"/>
    <dbReference type="OrthoDB" id="866855at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="278" mass="30159" checksum="5A75D511F41948F7" modified="2010-10-05" version="1">MQKTKQIVVIALIVLLVGALLAQPIKGLVDGKEEATSTKGTEASSVVNLDAISQASKQGLDANLIQDIADLESKVSKASGEDKIALYQQLAQKWDDVAKPAPQALIYEEMAKISPKFEYWLKAGQAYRAAYTNLQDTVLASALNQNAIHAFEEATKLDASNLDAKTGLGAAMVTGTNNPMAGIAILREVVAKEPKNVEANKTLGLFSLQSRQFDKAIDRFKTVIEQKPDAESYFYLATGYENIGMKSDAIAAFQKSKELASDPSLSQFIDKRIEELSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTQ8</accession>
    <name>D7VTQ8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="5">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="5">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="5">IPP transferase</shortName>
            <shortName evidence="5">IPPT</shortName>
            <shortName evidence="5">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">miaA</name>
        <name evidence="9" type="ORF">HMPREF0766_14378</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5 7">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001736.1">
        <property type="nucleotide sequence ID" value="NZ_GL379777.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14378"/>
    <dbReference type="EnsemblBacteria" id="EFK55817">
        <property type="protein sequence ID" value="EFK55817"/>
        <property type="gene ID" value="HMPREF0766_14378"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032616_0_1_10"/>
    <dbReference type="OrthoDB" id="1069591at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <begin position="52"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK55817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="318" mass="36761" checksum="EEBA960546491CD0" modified="2010-10-05" version="1">MINRQDSLHFSSEQSDVPMKNVIIILGPTASGKTALAVALAKKINGAIISADSRQVYRHMDIGTGKDLKEYEDIPYYLIDICEPGEKYNLSHFQHDFQKAYLDIVKSGRQPILCGGTGLYIQSVIQEKPYSHVPVNAELREELETLSREELLTRLDQQSIPADLRIDTSTRKRMIRGLEILAGLAKYERPAKLVSTSFTYQVFGIDPPVEIRRAKISQRLKQRIDQGLTEEVQHLLSRGVTHDDLQYYGLEYKYISYYLAGYLDWESCFTKLETEIHRYAKRQMTYFRKMEKDNIQIQWLEYGSTEQMCEEILNTKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTU4</accession>
    <name>D7VTU4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NlpC/P60 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">spr</name>
        <name evidence="4" type="ORF">HMPREF0766_14414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14414"/>
    <dbReference type="MEROPS" id="C40.004"/>
    <dbReference type="EnsemblBacteria" id="EFK55723">
        <property type="protein sequence ID" value="EFK55723"/>
        <property type="gene ID" value="HMPREF0766_14414"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016043_9_0_10"/>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="45"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK55723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="168" mass="18170" checksum="4D9883CFD988C40D" modified="2010-10-05" version="1">MVGGGYKGKGSTSGVLSDASSARGVDLTGSNLENYAKLLNVSVRDLNNRYLYGFINDWMGSPHRLGGQTKSGIDCSGFVGILYKDVYGKIIPRTSRDMGALVNSKRESQLKEGDLVFFSFGGGAIDHVGVYLHNNKFVHVSTRKGVIISDLTDSWYAKYFTGAGTIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTZ8</accession>
    <name>D7VTZ8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000015">
        <property type="protein sequence ID" value="EFK55693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14468"/>
    <dbReference type="EnsemblBacteria" id="EFK55693">
        <property type="protein sequence ID" value="EFK55693"/>
        <property type="gene ID" value="HMPREF0766_14468"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3317200_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="39" mass="4521" checksum="F296505BE1138AD5" modified="2010-10-05" version="1">MQEHPHSSDLGLFSLLPQAQGEDYEEEQFANRMKKTLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VG93</accession>
    <name>D7VG93_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001840.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10012"/>
    <dbReference type="EnsemblBacteria" id="EFK60068">
        <property type="protein sequence ID" value="EFK60068"/>
        <property type="gene ID" value="HMPREF0766_10012"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7XW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044582_0_0_10"/>
    <dbReference type="OrthoDB" id="861463at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021272">
        <property type="entry name" value="DUF2851"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11013">
        <property type="entry name" value="DUF2851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK60068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="432" mass="50702" checksum="6203069005155D03" modified="2010-10-05" version="1">MRIPEKLLHFIWRFRLFDQYNLQTLQKDDIKIEDVGHYNLNAGPDFLHANIRIGKEEWNGHIELHVTDKAWYLHQHDKDKSYDNVILHVIWDGDEEVRRSDGTSVPTLCLKPLIRSDLITKYEFIMGNSNAWIPCEKQIGDVEPLFVKQWLSRIAVERFHDKYDILIKQFTGYGCDFEKMAFVMLARAFGQKVNADSFQELAELIPFTLIHKYRNDVMKSEALVLGIAGFLGESEVFEDSYAGNLHKEYQYLRKLHRLPEMDKSRWKFMRMRPYNFPTFRIAQLVSLYRQQEGLFSYIMELETLAELRVLFEKIKLSEFWERHYTLQKSAVKHSTKMGKLAARTLIINSIVQLLFLYGKYFDQEMYICKAMAWLEELEAESNSIVNKFAAIGVPALCAADSQALIHLKSHYCAFKKCLDCQIGLQILKPIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGA7</accession>
    <name>D7VGA7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Efflux ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0766_10026</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001881.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10026"/>
    <dbReference type="EnsemblBacteria" id="EFK60082">
        <property type="protein sequence ID" value="EFK60082"/>
        <property type="gene ID" value="HMPREF0766_10026"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_10"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="26"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="323"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK60082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="415" mass="45546" checksum="F6A731229B9CE44F" modified="2010-10-05" version="1">MITVFRLLKESFGFAISALRDNKTRTFLSLLGVTIGIMTIIGVFSAVDTLRNNLEESVRKIGSSTLYVDKWPWDGGPDFPWWKYINRPEPKYNDYLALKSRMTTAEHIAYVFNIGNSVAKFKSNSATNITVNAATHEYYQTQSAEIIEGRNFTETESNVGSMVVVLGATIAEGLFPSGNALGQKISLLGRKLTVVGVLKKEGSGMLINTSSDDIAFIPFSLGRNLANYEQYNPSIVITVKPTYTLEEGESELKGLMRSIRRIAPQREDDFSLNKTTLITAQLDQMFTVINLAGFCIGIFSILVGGFGIANIMFVSVKERTNLIGIQKALGAKKYFILTQFLFESILLCLIGGAVGLIMVYGIAFVVKLATGFAVLVSLKMVIITCFLSTFIGLISGMIPAFMAANMDPVEAIRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGF3</accession>
    <name>D7VGF3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10072"/>
    <dbReference type="EnsemblBacteria" id="EFK60128">
        <property type="protein sequence ID" value="EFK60128"/>
        <property type="gene ID" value="HMPREF0766_10072"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3157945_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK60128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="48" mass="5166" checksum="B0E071D09A000EB9" modified="2010-10-05" version="1">MDAKVVSGAFTVFCDTAGHMVQGELGYVGGMLKICVLADRSGPDWRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGG6</accession>
    <name>D7VGG6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RecF/RecN/SMC N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002029.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10085"/>
    <dbReference type="EnsemblBacteria" id="EFK60141">
        <property type="protein sequence ID" value="EFK60141"/>
        <property type="gene ID" value="HMPREF0766_10085"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3950">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_477256_0_0_10"/>
    <dbReference type="OrthoDB" id="453077at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="212"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="571" mass="66411" checksum="8B99482E028699A1" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGM3</accession>
    <name>D7VGM3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996694.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10142"/>
    <dbReference type="EnsemblBacteria" id="EFK59225">
        <property type="protein sequence ID" value="EFK59225"/>
        <property type="gene ID" value="HMPREF0766_10142"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_4_1_10"/>
    <dbReference type="OrthoDB" id="1992113at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="113"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="176" mass="20710" checksum="416EB23AD91146B9" modified="2010-10-05" version="1">MSNQTLISIPEFEQIFEKWNKKVYQYALGKTSSPFIAEETVQRVFIKLWDNLFHKNVAVDIEAQVFCIARTTLLDIVKEERKRQLIMDMQPAEDNVPTPSELYRLKEMNASYKRAVERMPASRREVFLLSRLENLSYKEIAHRLSISPKTVENHIALALKALKKTLFILYILFFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGT1</accession>
    <name>D7VGT1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996851.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10200"/>
    <dbReference type="EnsemblBacteria" id="EFK59283">
        <property type="protein sequence ID" value="EFK59283"/>
        <property type="gene ID" value="HMPREF0766_10200"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033BIV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157095_1_0_10"/>
    <dbReference type="OrthoDB" id="2058194at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032272">
        <property type="entry name" value="DUF4834"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16118">
        <property type="entry name" value="DUF4834"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="99" mass="11529" checksum="235743E3E0DE9AC4" modified="2010-10-05" version="1">MAPLLKFLLIAFAVYFIVRFLFRLILPFAMRKAAERIMKKAQQSQYTTGNGPFGYQQYEQQTRADEGRVRVEYAPSKKEEKRRPGTATAGEFVDFEEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH73</accession>
    <name>D7VH73_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997208.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10342"/>
    <dbReference type="EnsemblBacteria" id="EFK59425">
        <property type="protein sequence ID" value="EFK59425"/>
        <property type="gene ID" value="HMPREF0766_10342"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZBK6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1575646_0_0_10"/>
    <dbReference type="OrthoDB" id="1695328at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018914">
        <property type="entry name" value="DUF2480"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10652">
        <property type="entry name" value="DUF2480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="173" mass="19550" checksum="E6D74ABD18560910" modified="2010-10-05" version="1">MIMEIQENIVNKVAQSGLITYDLASLAPAGELTEYDIKDNLFHGLILKEKDFREFIKEKDWSTYKDKHVAINCSTDAIIPTWAIMLLANKLEPFAKTVIFGTKEELESQLFQEKLATLDMSQFVDQRVVVKGCGDVHIPESAFVTFTVKLSKVAKSIMYGEPCSTVPVFKRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHF1</accession>
    <name>D7VHF1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997397.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10420"/>
    <dbReference type="EnsemblBacteria" id="EFK59503">
        <property type="protein sequence ID" value="EFK59503"/>
        <property type="gene ID" value="HMPREF0766_10420"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032XNU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118085_0_0_10"/>
    <dbReference type="OrthoDB" id="1906689at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="196" mass="22393" checksum="EA749216FAD36E7E" modified="2010-10-05" version="1">MKAGKIFLKPFDDFSERSLFITGVIFYFLGSLFAYFYHIKYNGFINIRFGESTALYFPFINNLVNTVLPSVILLLFAKIIYAKTRFIDVLNTVLIARIVIYLTSVLVVLDKSKSATEKITKAVAAGDIKLETVSKSDLFLVTFIGLFSLLIMIYYFYILIQGMKVAMNNKKIIVNGAIVIIFLIADLIVQFYFPYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHH7</accession>
    <name>D7VHH7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rplF</name>
        <name evidence="7" type="ORF">HMPREF0766_10446</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997475.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10446"/>
    <dbReference type="EnsemblBacteria" id="EFK59529">
        <property type="protein sequence ID" value="EFK59529"/>
        <property type="gene ID" value="HMPREF0766_10446"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0097">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_1_2_10"/>
    <dbReference type="OrthoDB" id="1398618at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="91"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="184" mass="19919" checksum="0A5232E5B44D5FBF" modified="2010-10-05" version="1">MSRIGKAPVAIPAGVTVAVSDKNLVTVKGPKGELTQQVDRDIKVAQEDGNIVVTRPTDQKKHKALHGLYRSLLNNMVVGVTEGYKTTQELVGVGYRASSNGNTLELTLGFSHQIVFVLPKEIKVSTTAEKGKNPTITLESIDKQLIGQVAAKIRSFRAPEPYKGKGIKFEGEVLRRKAGKSAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHK7</accession>
    <name>D7VHK7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Acyl carrier protein</fullName>
            <shortName evidence="7">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">acpP</name>
        <name evidence="11" type="ORF">HMPREF0766_10476</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 9">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10476"/>
    <dbReference type="EnsemblBacteria" id="EFK59559">
        <property type="protein sequence ID" value="EFK59559"/>
        <property type="gene ID" value="HMPREF0766_10476"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_1_3_10"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 7 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="35"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7 8">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK59559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="111" mass="12423" checksum="887CCC8FEE8D5215" modified="2010-10-05" version="1">MLTFAAPKNQKDLIIGEIYFSLHRFIKQLNYKIMSDIASRVKAIIVEKLGVDENEVTPEASFTNDLGADSLDTVELIMEFEKEFNVAIPDDQAENIGTVGQAIAYLEKNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHQ1</accession>
    <name>D7VHQ1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-dependent receptor plug domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_10520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997621.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10520"/>
    <dbReference type="EnsemblBacteria" id="EFK59603">
        <property type="protein sequence ID" value="EFK59603"/>
        <property type="gene ID" value="HMPREF0766_10520"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_18_0_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="119"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="271"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="780" mass="87658" checksum="2D90CD6F805B5302" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHT5</accession>
    <name>D7VHT5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10554"/>
    <dbReference type="EnsemblBacteria" id="EFK59637">
        <property type="protein sequence ID" value="EFK59637"/>
        <property type="gene ID" value="HMPREF0766_10554"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030V8I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1102263_0_0_10"/>
    <dbReference type="OrthoDB" id="1786025at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="263" mass="29833" checksum="1D9AE890D2385845" modified="2010-10-05" version="1">MIDNTSAQFEYNMKTFRILLYSIFLLSTLFPKHSFGQDTTPTVNKLWEGIGGKSKWDETHFILFSAAGNNTSTFIENPRKFLINRQNGDCRFEGATSSGDEITLLFNYRTNKIRKLYVNEVEQTNLDNFSAKNFPLITKQFKQDVSLLFLPTVLGSKQFKTGDAQQKIVDAEKLTVVTVNSTTDLNVKLNGKLFFNSESGKIRRWELSAEDDSVQYLIDNFKDIGDGLILPTTFKSLNDNSKSVIFSTVAAFVDMELSKFTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHX1</accession>
    <name>D7VHX1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">secG</name>
        <name evidence="11" type="ORF">HMPREF0766_10590</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SecG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997812.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10590"/>
    <dbReference type="EnsemblBacteria" id="EFK59673">
        <property type="protein sequence ID" value="EFK59673"/>
        <property type="gene ID" value="HMPREF0766_10590"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094156_1_0_10"/>
    <dbReference type="OrthoDB" id="2034545at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34182">
        <property type="entry name" value="PTHR34182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="76"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK59673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="123" mass="12597" checksum="9AC6F0A2ADD61F59" modified="2010-10-05" version="1">MQTLLIVLIILTSVLLALMVLIQNPKGGGLSSGFSGGSNLMGVKRTGDFLEKGTWTLVIALMVFCLAVNILGPSKGGAASKGGLSDQIEAPAQQGPLNLNPAQQQQQQQQAPAAAPGKTDSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHX4</accession>
    <name>D7VHX4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sigma-54 interaction domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cbrB</name>
        <name evidence="6" type="ORF">HMPREF0766_10593</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997818.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10593"/>
    <dbReference type="EnsemblBacteria" id="EFK59676">
        <property type="protein sequence ID" value="EFK59676"/>
        <property type="gene ID" value="HMPREF0766_10593"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_119_0_10"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="5">
        <location>
            <begin position="12"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK59676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="418" mass="47141" checksum="02F7DB5112535066" modified="2010-10-05" version="1">MDNQDIKNRFGIIGNSPLLNRAIDVARQVAPTDISVLIQGESGSGKEVFSHIIHQLSSRKHGPFIAVNCGAIPEGTIDSELFGHEKGSFTGAHEARKGYFEVVDGGTIFLDEVGELPLGTQARLLRVLETGEYIRVGSSKVQKTNVRVVAATNVDMFEAVKKGKFREDLYYRLNTVPLRIPALRERKEDINLLFRKFVVDFADKYRSPGVQLTDDAQQSLMNYSWPGNVRQLKNIAEQIAVLEKERIVNAVILQNYLPAEHSNLPVFVPQNAPKDDFSERDILYKVLFDMKKDMVDLKKLVVELIQKGVNPSTFDQNSPYINQLYQEVQPASSMLAEQSESSWTIHNARPAHSPNVDFNSYETQDVEEVEESLSLTEKESDLIKKALKKHKGKRKAAAQELGISERTLYRKIKDLNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHZ7</accession>
    <name>D7VHZ7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4983 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997865.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10616"/>
    <dbReference type="EnsemblBacteria" id="EFK59699">
        <property type="protein sequence ID" value="EFK59699"/>
        <property type="gene ID" value="HMPREF0766_10616"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024677_0_0_10"/>
    <dbReference type="OrthoDB" id="1333010at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032309">
        <property type="entry name" value="DUF4983"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16356">
        <property type="entry name" value="DUF4983"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106973" description="DUF4983 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4983" evidence="3">
        <location>
            <begin position="488"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="586" mass="65224" checksum="DC1238FBE45866D2" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI02</accession>
    <name>D7VI02_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_10621</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10621"/>
    <dbReference type="EnsemblBacteria" id="EFK59704">
        <property type="protein sequence ID" value="EFK59704"/>
        <property type="gene ID" value="HMPREF0766_10621"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_1_3_10"/>
    <dbReference type="OrthoDB" id="554994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="128"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="353"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="511" mass="59238" checksum="B2BFDA7A3AC70B95" modified="2010-10-05" version="1">MKRLLYIGFTLITTLFVTSCGKDFLNVTPIDNLSGNNYWKTKADFEQFTGGIYSTFREATMRQIFFPATGDFRCAPINRAPGSNGAGATFNHLTYLKFNDLKSLFAQYYKPERAFGENNDYFGFQQVRKWNNFFLMVQKANILYYQLENVGSGILSEADIKKYKAEAVFLRNLAYFFMVRVWGDVPYYTQAFHSTPSPRVNFVEVLQKGIADMSAHYKDLPWTYEDQSIVAIRAMRGSAIALMMHMNMWVAGFSSNKTPFYEATAALGKEIMEENGGAYTLLPLERTKEIFKGRTKEGLFEIAQNFNYGESFHLSSTFSDYVLRAPNKVVTRSYIYYSSKFLEKLYPPGERDLRKSYWFDEFMYNTEGQFQMLKFVNVFMEEGEDNNPDDNQVVFRYNDAIMLRAEALAELERDGEAKLVINEVRRRAGAKEAASENGKDLKDLIWYERARELMGEGHWYYDLVRTKKVINAEYTEAPMSVDAFNRGGWTWPIDQSAFANNPFMTYNAYWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI34</accession>
    <name>D7VI34_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ser/Thr phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_10653</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997938.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10653"/>
    <dbReference type="EnsemblBacteria" id="EFK59736">
        <property type="protein sequence ID" value="EFK59736"/>
        <property type="gene ID" value="HMPREF0766_10653"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016483_1_0_10"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032288">
        <property type="entry name" value="Metallophos_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032285">
        <property type="entry name" value="Metallophos_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16370">
        <property type="entry name" value="MetallophosC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16371">
        <property type="entry name" value="MetallophosN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107254" evidence="1">
        <location>
            <begin position="20"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="MetallophosN" evidence="4">
        <location>
            <begin position="39"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="138"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="MetallophosC" evidence="3">
        <location>
            <begin position="344"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="522" mass="58345" checksum="83FB9988CB945CC9" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI55</accession>
    <name>D7VI55_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plant Basic Secretory Protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997979.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10674"/>
    <dbReference type="EnsemblBacteria" id="EFK59757">
        <property type="protein sequence ID" value="EFK59757"/>
        <property type="gene ID" value="HMPREF0766_10674"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZBFG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093072_0_0_10"/>
    <dbReference type="OrthoDB" id="1514411at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007541">
        <property type="entry name" value="Uncharacterised_BSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321">
        <property type="entry name" value="PTHR33321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04450">
        <property type="entry name" value="BSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106924" evidence="1">
        <location>
            <begin position="25"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="241" mass="28159" checksum="C47678D6C20D3C09" modified="2010-10-05" version="1">MKKMKRILCCLLLMIGTGHVTVYAQNNWQHTDDDRKEAFEVDTINKGKYSLIWINKQADFDPALKQKLIDTYFVNYPKLAKKYNKHTRKQVSFVIDPGYNGVAATAGGIVRYSPGWFKKNPNDIDVVTHEVMHIVQGYPNGAGPWWITEGIADYVRFTEGVDNASANWKLPDVNEKQKYTDSYRITARFFYWLDRRVKKNIIKALDQKMRTKKYNDSFWKQQTGQDLDQLWDRYAADPSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIE0</accession>
    <name>D7VIE0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Competence/damage-inducible domain protein CinA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cinA2</name>
        <name evidence="2" type="ORF">HMPREF0766_10759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998147.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10759"/>
    <dbReference type="EnsemblBacteria" id="EFK59842">
        <property type="protein sequence ID" value="EFK59842"/>
        <property type="gene ID" value="HMPREF0766_10759"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_4_0_10"/>
    <dbReference type="OrthoDB" id="2021160at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA" evidence="1">
        <location>
            <begin position="11"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="170" mass="18869" checksum="BC55D137903E43C9" modified="2010-10-05" version="1">MDINSDKLNFCGDYFSKKNLKLILAESMTAGFISSVISLEINSGDYFLGSIVCYHDDMKISSLGVDPELIKKAGAVSEEVTHALLNGLRDRYDAHIAVAVTGYAFEDKAISDENPVGTVFLQIQYQNSFINKKCLFTGEAHDIITATANEIIENLYEMVLLSETQERDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIH2</accession>
    <name>D7VIH2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding protein</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0766_10791</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="10"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998210.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10791"/>
    <dbReference type="EnsemblBacteria" id="EFK59874">
        <property type="protein sequence ID" value="EFK59874"/>
        <property type="gene ID" value="HMPREF0766_10791"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_10"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="31"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="346"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="379"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK59874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="587" mass="66750" checksum="C15927019A900122" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIM2</accession>
    <name>D7VIM2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VanZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998307.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10841"/>
    <dbReference type="EnsemblBacteria" id="EFK59924">
        <property type="protein sequence ID" value="EFK59924"/>
        <property type="gene ID" value="HMPREF0766_10841"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096028_2_3_10"/>
    <dbReference type="OrthoDB" id="2074871at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="37"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="126" mass="14408" checksum="95EF5C26C3E7C917" modified="2010-10-05" version="1">MRFLINYSWTILWSIIVLILISLPSNDFDGVSTFQGFDKLVHTGFFFVFTVLSYFGSVLQSKRRATKLKTSIIIILIAVSFAFLTEGIQLYLTTTRSADWWDIFADTVGIGMGVFAYSLLYHKRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIP6</accession>
    <name>D7VIP6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998361.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10865"/>
    <dbReference type="EnsemblBacteria" id="EFK59948">
        <property type="protein sequence ID" value="EFK59948"/>
        <property type="gene ID" value="HMPREF0766_10865"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2453089_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="89" mass="10028" checksum="59438E6005022214" modified="2010-10-05" version="1">MKAYFKKIGNADLSFGILYWNLFFGGLPFILVAAIASFGIKPVAVNNVYYDGIIGFIIPLISLPIVVFISTVFIWFFLFVGKNLIRIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIS1</accession>
    <name>D7VIS1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998413.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10890"/>
    <dbReference type="EnsemblBacteria" id="EFK59973">
        <property type="protein sequence ID" value="EFK59973"/>
        <property type="gene ID" value="HMPREF0766_10890"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199838_0_0_10"/>
    <dbReference type="OrthoDB" id="2016549at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="75" mass="8954" checksum="F64ED6C63F095CA5" modified="2010-10-05" version="1">MNKYLRRGLILSVSGILITYGGYWMMHQEIDLYKIIMILGVLVFSWGFVTIIYSLIRKIERKSIMESRQEEQHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIV4</accession>
    <name>D7VIV4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998483.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10923"/>
    <dbReference type="EnsemblBacteria" id="EFK60006">
        <property type="protein sequence ID" value="EFK60006"/>
        <property type="gene ID" value="HMPREF0766_10923"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006229_4_2_10"/>
    <dbReference type="OrthoDB" id="1971388at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK60006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="379" mass="43730" checksum="D80DBC0E35A0479F" modified="2010-10-05" version="1">MQFKDIIGHQEIKDHLVRTVLENRVSHAQLFLGPEGSGSLALAHAYAQFINCEAKLADDSCGQCNSCRKYAKIIHPDLHFSFPFFAKGKEETSVTYMEEWRAAFLKNPYLSLEYWRGQLEADNKQANINIAEAHDIIKKLSLKAFEAEYKILIMWLPEYLDTQGNALLKLIEEPPEKTLFLLVSENQDRILNTIISRTQLVKIQKLPHQDITNYLVEERGIQKEQAGEIAFIADGNLQQALNLLSESGNHLDLLIRWLRFIVSDAGLHMISICDDELSKLGRENQKSFLLYAINMMRQIILIKEELHDLVFLPEKELEFVNKFAPLFTVNQIEEAVSLFEKTHYCVERNANPKILFLDLSLQLVLLFKYQTFPKGTQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ57</accession>
    <name>D7VJ57_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000362.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11026"/>
    <dbReference type="EnsemblBacteria" id="EFK58910">
        <property type="protein sequence ID" value="EFK58910"/>
        <property type="gene ID" value="HMPREF0766_11026"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_1_10"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="331" mass="37671" checksum="CA763A30B51217ED" modified="2010-10-05" version="1">MKEKVLITGASGFVGFHLVEAAKSAGLEVHAAVRKSSAVSQIEHAVDKFVYPDYENTDELVALLEEHQYQYVIHAAAMTRAKQEEDLVRVNKQYTLNLFSAVFKAAIPLKRATFVSSLAAVGPISIEQGLISEQSPYHPVTAYGRSKRESEKAVKEQFGDKPLTIIRPTAVYGPREKDIYVLFKTLNSGVDAYIGRSPQQLSFIYVKDLVQAILQSCFATHAQFKIYNITDGQVYDRYEMANIFNNVLQKKTFRIHLPNRVVGLVARLFEWAYKRSAKIPVLYPERLNELTAANWACDITAARRELGFDPQFDLKRGLEETLFWYKEHKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJG3</accession>
    <name>D7VJG3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000630.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11132"/>
    <dbReference type="EnsemblBacteria" id="EFK59016">
        <property type="protein sequence ID" value="EFK59016"/>
        <property type="gene ID" value="HMPREF0766_11132"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1843847_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="139" mass="16614" checksum="081B470E806FEB6C" modified="2010-10-05" version="1">MFINNGLPGFIREGFFNKYSLHCNTYQLLIIMENQTYLKEREIRKSKVVFWVSVAILIFFASTVFVYGSLLYLPEWIIVLHSIADQLVRIPAILACFVLLGISGYYILFKRQYYYRWYFNVLYNIFSIALIFFGDYFMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJJ1</accession>
    <name>D7VJJ1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1735 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000676.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11160"/>
    <dbReference type="EnsemblBacteria" id="EFK59044">
        <property type="protein sequence ID" value="EFK59044"/>
        <property type="gene ID" value="HMPREF0766_11160"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050496_1_0_10"/>
    <dbReference type="OrthoDB" id="1832114at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013728">
        <property type="entry name" value="DUF1735"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08522">
        <property type="entry name" value="DUF1735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107020" description="DUF1735 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1735" evidence="2">
        <location>
            <begin position="29"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="379" mass="42188" checksum="6014C4E3860B6895" modified="2010-10-05" version="1">MKMKTLKYILLSLSCLILSCKNAEYQIIDNSIYISSAANSSEKAETITMNNGADINILVRLAKKVSEDVEVEVKLTPSLLDNYNKETSSEYLPVPNFSLPANAKVVIPAGEISAIYTIRVEDFETNGNRYALGVELGNVLKGNIANSNSQSRFIYLLAKPLRVSVPEMSGSTTQVNALPADKWGISTIQWSLECWTKMSAYSINNQAIFNTGSSDHEIYIRFGDANRPYNYLQIKTLGGQIQTASNLEANKWYHWAFVYDGNTLTIYRDGELDVKFQPPAPNGGSVRFDALQMIASGSTYFRDRCQMAQVRLWKKAITQNQIKNNMYFAINAKNPDLIGYWPMDEGAGNTFKDITGNGHDAVAGAGILRSWISNVDFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJJ8</accession>
    <name>D7VJJ8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11167</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000691.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11167"/>
    <dbReference type="EnsemblBacteria" id="EFK59051">
        <property type="protein sequence ID" value="EFK59051"/>
        <property type="gene ID" value="HMPREF0766_11167"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0545">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013615_7_2_10"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106955" description="Peptidyl-prolyl cis-trans isomerase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="95"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="201" mass="22206" checksum="4D27E8C9E3B5DE03" modified="2010-10-05" version="1">MTAKSLGKLLIMGLATISLFASCIKDDDVFNDYEQYQKESVDIQNYIRTNFPTAKKDTTGIWFELIEEGEGENFQYKTETVSDPNTGQSVVRALAPTVTVKFTGKLLTGSVVQNNQTETGIAVSLAQQPASWQLAFLPYEISGVTTQIRGLTRNGLKAGSIIRFVTPSYYAYGNMTVGQVPANSPLDYTIEVIKMEYKDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJM2</accession>
    <name>D7VJM2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bac_rhamnosid6H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000740.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11191"/>
    <dbReference type="EnsemblBacteria" id="EFK59075">
        <property type="protein sequence ID" value="EFK59075"/>
        <property type="gene ID" value="HMPREF0766_11191"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_285085_0_0_10"/>
    <dbReference type="OrthoDB" id="84619at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028028">
        <property type="entry name" value="DUF4450"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14614">
        <property type="entry name" value="DUF4450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107217" description="Bac_rhamnosid6H domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="2">
        <location>
            <begin position="429"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1205" mass="134660" checksum="518B32FE37E374BF" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJU4</accession>
    <name>D7VJU4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Bacterial type II secretion system domain protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">gspF</name>
        <name evidence="12" type="ORF">HMPREF0766_11263</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GSP F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998631.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11263"/>
    <dbReference type="EnsemblBacteria" id="EFK58546">
        <property type="protein sequence ID" value="EFK58546"/>
        <property type="gene ID" value="HMPREF0766_11263"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035032_0_0_10"/>
    <dbReference type="OrthoDB" id="1268170at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001992">
        <property type="entry name" value="T2SS_GspF/T4SS_PilC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00874">
        <property type="entry name" value="T2SP_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="11">
        <location>
            <begin position="52"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="11">
        <location>
            <begin position="254"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK58546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="384" mass="44115" checksum="3F0303938E1B414A" modified="2010-10-05" version="1">MPNIDISQYKKKKKTTTSGSPVTDEETNIWSFMNKDISFGDGQLPDRKKEEFYLELSTLLLSGVDLRTSFDLVLLEKEKSKNGKIFTGIKDEVLKGDALSEAIRKTGKFSDYEYYSIRIGEETGKLGQVLKELAQFYKNKISQRRKIVSALTYPAIVFSTSIGAVFFMLKFVVPMFADVFTRFGGQLPWITAFILKVSNFLDQTFWGFILIVLTVMIIAYVNRKKLWWRKGYAKVLLKLPLFGDIIRKIHLARFANTMRLLVSTNTPLLTSIQLVQQMADFYPIEESLRQTEALIMRGESLHQSLGKFSFYPAKIVQLIKVGEEVNRLDFFFEKIADQLTEEVEYRTSTISNLLEPFIIIFLGLVVGLILIAMYLPMFQMSNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJX8</accession>
    <name>D7VJX8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="15">ATP-PFK</shortName>
            <shortName evidence="15">Phosphofructokinase</shortName>
            <ecNumber evidence="15">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">pfkA</name>
        <name evidence="17" type="ORF">HMPREF0766_11297</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 15">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="15"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998721.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11297"/>
    <dbReference type="EnsemblBacteria" id="EFK58580">
        <property type="protein sequence ID" value="EFK58580"/>
        <property type="gene ID" value="HMPREF0766_11297"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020655_0_1_10"/>
    <dbReference type="OrthoDB" id="1421302at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00339">
        <property type="entry name" value="Phosphofructokinase_I_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012828">
        <property type="entry name" value="PFKA_ATP_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02482">
        <property type="entry name" value="PFKA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="12 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 15 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="16">
        <location>
            <begin position="6"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator; shared with dimeric partner" evidence="15">
        <location>
            <begin position="24"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="173"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator" evidence="15">
        <location>
            <begin position="189"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator" evidence="15">
        <location>
            <begin position="217"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="256"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="105"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFK58580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="327" mass="35325" checksum="DB0242916FD60CF2" modified="2010-10-05" version="1">MNTISNIGVFTSGGDAPGMNACIRAVVRTAVYEGKKVTGIYHGYQGMLDGTFVEMNSRSVSNIIQKGGTILKTARCIEFRTPEGRAKAYENLKAQGIDGLVAIGGDGTFTGADFFSREYDIPVMCIPGTIDNDLYGSDYTLGYDTATNTVIDAIDKIRDTAASHGRLFFIEVMGRDSGCIALNAGIAGGAEAIMLPEKETAIDELIDLLERAAFKQKTSTIVIVAEGDKNGGAYNVAKRVKEKFDYYDTKVSILGHLQRGGSPSSFDRVLASRMGYAAVKHLLQGKTRMTVGLRGNEIILTPLEEALNNKEFKLSNDMLEISQIMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJY7</accession>
    <name>D7VJY7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998753.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11306"/>
    <dbReference type="EnsemblBacteria" id="EFK58589">
        <property type="protein sequence ID" value="EFK58589"/>
        <property type="gene ID" value="HMPREF0766_11306"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122784_0_0_10"/>
    <dbReference type="OrthoDB" id="1046637at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011467">
        <property type="entry name" value="DUF1573"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07610">
        <property type="entry name" value="DUF1573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107595" evidence="1">
        <location>
            <begin position="21"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="155" mass="16210" checksum="2574D5B5ED458A62" modified="2010-10-05" version="1">MKINKLAFAGILSMACLVSACGNGTKTNVAKAAQGDSVAGDTTQQKGQEALGKIEFEETAFDFGQVKEGEVVQHTFTFTNVGEAPVILSEVNASCGCTTPHYSKSPVLPGKKGEVKVAFDSKGQVGKQQKIVTVMSNATNGISTVQLRGEVQKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK25</accession>
    <name>D7VK25_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sodA3</name>
        <name evidence="9" type="ORF">HMPREF0766_11344</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998864.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11344"/>
    <dbReference type="EnsemblBacteria" id="EFK58627">
        <property type="protein sequence ID" value="EFK58627"/>
        <property type="gene ID" value="HMPREF0766_11344"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031625_0_1_10"/>
    <dbReference type="OrthoDB" id="1440645at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="7">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="8">
        <location>
            <begin position="91"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK58627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="206" mass="23377" checksum="A818BD6BF6330599" modified="2010-10-05" version="1">MAYQLPALPYSYDALEPFIDKATMEIHHDIHHQAYVDNLNKALDGLSAPESLTALLENISNYSPAVRNNAGGHFNHELFWNILSPTARTQPQGALADAILANWGSLDNFKEQFGQLTMTRFGSGWAWLYVKYNGSIAICSTPNQDNPLMDINITDRGFPIMGLDVWEHAYYLKYQNKRADYLAAFWSILDWGAVSRNYDAIRNRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKK2</accession>
    <name>D7VKK2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11521"/>
    <dbReference type="EnsemblBacteria" id="EFK58804">
        <property type="protein sequence ID" value="EFK58804"/>
        <property type="gene ID" value="HMPREF0766_11521"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8F6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076044_0_0_10"/>
    <dbReference type="OrthoDB" id="1773281at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="285" mass="31811" checksum="CC73F0BBEF60A6CC" modified="2010-10-05" version="1">MRDSYCKSPFIYDYKNVVPSYNSDSILNANISLRKSFSDQSILILNALGNLDEVEAIIKLKSDSTMASQLKILQLKNVINNKISISLTELDAVAAEYDCEGERVAQMGNFVDNINAGKSNKLILYSIVAGAATSIAGGIVKNDMWSDIIGIGGGVLGAGFGLATFNPKGRKVEFIHGRNLLRDVWHEKLESPNFPPFIWYMFTEKKFSNRGEKSLIQNMKDRWLKYQFAGDTESADKSVIFSDGGQYLAEDLHNRATMLNQMQSATRTINQNISYLLLELDKLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKQ1</accession>
    <name>D7VKQ1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_11570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999438.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11570"/>
    <dbReference type="EnsemblBacteria" id="EFK58853">
        <property type="protein sequence ID" value="EFK58853"/>
        <property type="gene ID" value="HMPREF0766_11570"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1150">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_619292_0_0_10"/>
    <dbReference type="OrthoDB" id="624150at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="292"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="356"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="431" mass="48648" checksum="EA63B7D5C99CF778" modified="2010-10-05" version="1">MISQIIFSILFIAAIVFFTGNACKIWRNIRLGKNVDRFDRPGERLKTMLLVAFGQQKMFKKPLPALLHLFVYAGFCIINIEMIEIIIDGIFGTHRVLSFMGGFYNFLIYAFELLAFSVLAACVVFFIRRNVLKIKRLQQKELNNWPKTDANLILITEILLMAAFLFMNAADHKLQLAGVSHYHQAGSFPVSSWLMGILPDNPSALIAIERGCWWFHIIGVLLFLNYLPISKHLHIILAFPNTYFSKLEPKGKFENMVSVTNEVKAMLDPSFTPPAADGISRFGVKDVQDLTWKNLLDAYTCTECGRCTSACPANMTGKLLSPRKIMMDTRDRLEEVGKSIDKNGSAVEDNKSLLDTYISREEIWACTSCNACVEQCPVNINPLEIIMGLRQYAVMEESQAPSSINAMFGNLENNGAPWKYAQADRANWANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKY3</accession>
    <name>D7VKY3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_11652</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999622.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11652"/>
    <dbReference type="EnsemblBacteria" id="EFK58256">
        <property type="protein sequence ID" value="EFK58256"/>
        <property type="gene ID" value="HMPREF0766_11652"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_3_10"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="187"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="292" mass="33847" checksum="CAE5710633B19288" modified="2010-10-05" version="1">MRIVQFTVPVPDQGSVCVQEDILPEFYGNYHRHKEIQLTYILKGKGTFLIGNFSHHFQEDEIFIVDADEPHMFKKADMVSEQANENGIHAIHIFFDYHNFTSFLNLSEFDSVKSFLEHIQGSKKLTADYAVHLKSRFLDINAAEGTSRLLQFLDLVDYLSKKIELWTSLYTGIPQKKYSDAEGIRINDIFQYTFKHFAEKISLEQISSIAHMTPHAFCKYFKKHTRKTYVTFLNEIRIEQACKLLINGLSENVADIAFRTGFNNVVNFNRVFKKVTKLSPSDYLTTYKAKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL76</accession>
    <name>D7VL76_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="2">2.4.2.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hpt</name>
        <name evidence="2" type="ORF">HMPREF0766_11745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999843.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11745"/>
    <dbReference type="EnsemblBacteria" id="EFK58349">
        <property type="protein sequence ID" value="EFK58349"/>
        <property type="gene ID" value="HMPREF0766_11745"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0634">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073615_0_2_10"/>
    <dbReference type="OrthoDB" id="1819460at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="19"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="181" mass="20560" checksum="3FC3BD0326667ACC" modified="2010-10-05" version="1">MKYLTVDNLEFEIMIDHDQIQKRIRLIGIDLNMRFENKHPVFIGVLNGCFMFMSDLMKQVVIPSELSFVKLASYKGVEQQDIAELIGVGMDLTGRDVIIVEDIIDSGHSLKHTMEALEKLGVASISVCALLMKPANLQVQFDNIMYIGFEIEKEFVIGYGLDYNGQCRNLPDIYQHIPSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL78</accession>
    <name>D7VL78_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11747"/>
    <dbReference type="EnsemblBacteria" id="EFK58351">
        <property type="protein sequence ID" value="EFK58351"/>
        <property type="gene ID" value="HMPREF0766_11747"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2556549_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="82" mass="9627" checksum="41EC5D0094FE76A5" modified="2010-10-05" version="1">MNEKKPVFLSVIQYKYRQIKAFFEQENKLVSLIFNPFQNCAISFCLLFICIDTPQKNEVRSNLHFKNIQMTGLCFAIVSFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLG3</accession>
    <name>D7VLG3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000101.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11833"/>
    <dbReference type="EnsemblBacteria" id="EFK58436">
        <property type="protein sequence ID" value="EFK58436"/>
        <property type="gene ID" value="HMPREF0766_11833"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025928_2_0_10"/>
    <dbReference type="OrthoDB" id="251905at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024302">
        <property type="entry name" value="SusD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12741">
        <property type="entry name" value="SusD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107657" evidence="1">
        <location>
            <begin position="26"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="556" mass="61702" checksum="086C003BB4FC52DF" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLH2</accession>
    <name>D7VLH2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11842"/>
    <dbReference type="EnsemblBacteria" id="EFK58445">
        <property type="protein sequence ID" value="EFK58445"/>
        <property type="gene ID" value="HMPREF0766_11842"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2976967_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="58" mass="6678" checksum="8D5B1560693DB48E" modified="2010-10-05" version="1">MFFESPQLLGLKDSKQRVTDLLRTGMRVLNSVNFSECVEGKPLFIKMTIIRVEITFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLL8</accession>
    <name>D7VLL8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein TonB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">tonB2</name>
        <name evidence="12" type="ORF">HMPREF0766_11888</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell inner membrane</location>
            <topology evidence="1 9">Single-pass membrane protein</topology>
            <orientation evidence="1 9">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TonB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000219.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11888"/>
    <dbReference type="EnsemblBacteria" id="EFK58491">
        <property type="protein sequence ID" value="EFK58491"/>
        <property type="gene ID" value="HMPREF0766_11888"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065795_0_0_10"/>
    <dbReference type="OrthoDB" id="2074833at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031992">
        <property type="term" value="F:energy transducer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003538">
        <property type="entry name" value="TonB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01374">
        <property type="entry name" value="TONBPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TonB_C" evidence="11">
        <location>
            <begin position="212"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="80"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="150"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK58491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="292" mass="31974" checksum="E8037FA92A356079" modified="2010-10-05" version="1">MFGSKLDLFKKEWLDVVFANRNKEYGAYQLRKLAPRATNVGLAAVIGLVILLSIPKIFNIKLIPDKPVEPPPVITEVTLEDLEIPEPPKEEEEPLPAEEQPQRIAQEPPAEDLIRFPEPKVVPKNQVKEEVAAQEDFKDDKKTPARITLKGTKGASGVPTGEFGPKKVDGAVTGTEKGSPDGTGSNEIFTAVEVNPEPPGGMKTFMKWIGDNYQYPSAALEQGVNGVVQVSFVVEKDGSLTDIKVQRDLQYGTGQAAVTLLKKAKKWSPGIQNGRPVRVAYTLPIRLNTINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLP5</accession>
    <name>D7VLP5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000286.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11915"/>
    <dbReference type="EnsemblBacteria" id="EFK58518">
        <property type="protein sequence ID" value="EFK58518"/>
        <property type="gene ID" value="HMPREF0766_11915"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7P2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018090_0_0_10"/>
    <dbReference type="OrthoDB" id="1560687at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107024" evidence="1">
        <location>
            <begin position="24"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="798" mass="92940" checksum="7FB137C1F310F7B8" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLT4</accession>
    <name>D7VLT4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001580.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12188"/>
    <dbReference type="EnsemblBacteria" id="EFK58196">
        <property type="protein sequence ID" value="EFK58196"/>
        <property type="gene ID" value="HMPREF0766_12188"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_258838_0_0_10"/>
    <dbReference type="OrthoDB" id="1733430at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107396" evidence="1">
        <location>
            <begin position="22"/>
            <end position="1334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1334" mass="148744" checksum="9F216415E12746C2" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM41</accession>
    <name>D7VM41_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6377 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001271.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12038"/>
    <dbReference type="EnsemblBacteria" id="EFK58046">
        <property type="protein sequence ID" value="EFK58046"/>
        <property type="gene ID" value="HMPREF0766_12038"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037195_0_0_10"/>
    <dbReference type="OrthoDB" id="950351at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045957">
        <property type="entry name" value="DUF6377"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19904">
        <property type="entry name" value="DUF6377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6377" evidence="3">
        <location>
            <begin position="256"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="546" mass="63870" checksum="768CF5561A7667E9" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM88</accession>
    <name>D7VM88_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphate-selective porin O and P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001371.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12085"/>
    <dbReference type="EnsemblBacteria" id="EFK58093">
        <property type="protein sequence ID" value="EFK58093"/>
        <property type="gene ID" value="HMPREF0766_12085"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_749750_0_0_10"/>
    <dbReference type="OrthoDB" id="1092953at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010870">
        <property type="entry name" value="Porin_O/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07396">
        <property type="entry name" value="Porin_O_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="391" mass="44781" checksum="65089D6A03F4E53A" modified="2010-10-05" version="1">MKKHLFFHMKIHALCPFFLILIIHVFPVNKVYAQVPDSTWGKDFENYPKFQFKGLFQARFTTSLNKDVDVGGLHHADHSGTDNTFALKYMRAQVQAKISKRTEVVALVNLADFKSDPKTKVLENAYLKYTFSPKIALTVGQFRPWFGIEETYPVDIIKSLDWSNQYFEFGKNGWTSFQLGASVGGTLHFGTMPFQYALSVVNGNGKNQISDNNNGKQYLSRMVFGLSRKYGVNLGVNGGVGDAFHKTVYALGADITSNIALSPRWFLDMQVEAKQAVNHNLYFALGEDVRSPDINDYQMRGIYFLPNLRYEIKHKNLSAIEVSCRYEYLDVNFKKDKNPRETITPMFGLEFLKNYGARIQVGMQIDRYKHQIENTTTYNGNLFILQVQSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMA6</accession>
    <name>D7VMA6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_12103</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001406.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12103"/>
    <dbReference type="EnsemblBacteria" id="EFK58111">
        <property type="protein sequence ID" value="EFK58111"/>
        <property type="gene ID" value="HMPREF0766_12103"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_1_3_10"/>
    <dbReference type="OrthoDB" id="554994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="84"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="404"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="515" mass="58150" checksum="7DE18699E3D75B38" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMC2</accession>
    <name>D7VMC2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001440.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12119"/>
    <dbReference type="EnsemblBacteria" id="EFK58127">
        <property type="protein sequence ID" value="EFK58127"/>
        <property type="gene ID" value="HMPREF0766_12119"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056702_0_0_10"/>
    <dbReference type="OrthoDB" id="2027419at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107337" evidence="2">
        <location>
            <begin position="29"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="125"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="307" mass="34098" checksum="342DB3C52AE695A6" modified="2010-10-05" version="1">MNKLLKSSLYKKIAVIAFASFSISNLYASSWKTDFSPKDSIGVENVKGEIYILHKVEQKDTYYKLGRQYNAIVKNIMAANNSKDLRPGDTVKIPTGRPFQQTAKAVTQPEKSKNAGNPQQQTPLTEYKVGKSETLYAISRRFGVSVDDIKKLNNLTSNSLKENQLLKIPNNTPTPPKPVEEPKIVLTPIDTTRVDSTERDSSYNEISANKYGIREKKERGIAVWMSNLNSDGKSNLALHKTAPIGTILKITNPMTHNVTYAKVVGKFNDNAETENAIVVLSKSAASYIGALDKRFLVEINYGVPLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMD9</accession>
    <name>D7VMD9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide diphosphorylase (carboxylating)</fullName>
            <ecNumber evidence="4">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">nadC</name>
        <name evidence="13" type="ORF">HMPREF0766_12136</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NadC/ModD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001466.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12136"/>
    <dbReference type="EnsemblBacteria" id="EFK58144">
        <property type="protein sequence ID" value="EFK58144"/>
        <property type="gene ID" value="HMPREF0766_12136"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0157">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039622_0_1_10"/>
    <dbReference type="OrthoDB" id="1718114at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="12">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="11">
        <location>
            <begin position="112"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="133"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="245"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="266"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFK58144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="285" mass="31259" checksum="0F8AE598C072D822" modified="2010-10-05" version="1">MDKEFVEKLAVFVREALQEDVGDGDHTTLSTIPAEQQGEAKLLVKEDGILAGVEVARKLIEIADPGLKIKTLLTDGTAVKAGDIAFYLEGDIHSILKVERLVLNVMQRMSGIATRTHEYVSVLEGTKTKVLDTRKTTPLLRFLEKEAVKIGGGVNHRFGLYDMILIKDNHVDYAGGITKALTSAENYRQQLGKEIQIEIEVRNLKELDEVLAFGSVDRVMLDNFTPQQVKEAVDIIDGRLVTEASGGITIDTIRAYAEAGVDYISVGALTHSVKSLDLSLKAKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMH2</accession>
    <name>D7VMH2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12169"/>
    <dbReference type="EnsemblBacteria" id="EFK58177">
        <property type="protein sequence ID" value="EFK58177"/>
        <property type="gene ID" value="HMPREF0766_12169"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085936_1_0_10"/>
    <dbReference type="OrthoDB" id="1866464at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="207" mass="23562" checksum="4F58ED9BCACE4B97" modified="2010-10-05" version="1">MKNKKLIAVITGDLINSRKVDAAVWMPVLDETLKQISSRYDIYRGDSFQSEVELQQAINHLFYIKAKIKSLKNLDVRMTIGIGTIDYQDAHVRTSAGEAFLHAGERFDALKKDTVAIRSPWPDLDEGLELMLQLSMEIAGRWTENMAEAVAVSLKHPDMNQHELAAVLNRKYQSQVSTELNKAGYSKIKRVIDYCTEQIVKKCYIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMK5</accession>
    <name>D7VMK5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative serine O-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cysE</name>
        <name evidence="3" type="ORF">HMPREF0766_12225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992644.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12225"/>
    <dbReference type="EnsemblBacteria" id="EFK57152">
        <property type="protein sequence ID" value="EFK57152"/>
        <property type="gene ID" value="HMPREF0766_12225"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_1_1_10"/>
    <dbReference type="OrthoDB" id="1639008at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="275" mass="30621" checksum="5672A1D2663D29DB" modified="2010-10-05" version="1">MSADKNMESFYTHLYAKQLEVQDMPSNKRIAQWAMNLLHLLFPERNSNSYQSVEEIRVAFQQSENELFDLLIRTKACSQCDNQEISSVFFTCLPGLYEIMLTDARSILAGDPAAKSIREVIRTYPGFMAISVFRLANQLHKQGVPLIPRILTEYAHSKTGIDIHPGATIGQYLYIDHGTGLVIGETSVIGDHVKLYQGVTLGALSVEKNMANLKRHPTIEDHVIIYSGATILGGETVIGHHSIIGGNVWLTSSIDPYTTVYHQANSKFIDAKPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMM7</accession>
    <name>D7VMM7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">ffh</name>
        <name evidence="9" type="ORF">HMPREF0766_12247</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992694.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12247"/>
    <dbReference type="EnsemblBacteria" id="EFK57174">
        <property type="protein sequence ID" value="EFK57174"/>
        <property type="gene ID" value="HMPREF0766_12247"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_6_0_10"/>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="8">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="106"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="189"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="247"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK57174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="445" mass="48871" checksum="A5D38AE67EFC9038" modified="2010-10-05" version="1">MFQNLQDKLDRAFKVLKGQGNITEINVAETMKEIRKALLDADVNYKTAKSFTDDVKQKALGQNVLTSISPGQLLTKIMNDELTELMGGAVTELDTSKNPTVILIAGLNGAGKTTFSGKLANYLKDKKGKKPLLVAGDVYRPAAIDQLEVLGGQVGVPVFVNRESNDPIAISQAGVEEAKRNGHNVVIIDTAGRLAIDEALMVEITAVKEATKPQEILFVVDSMTGQDAVNTAKAFNDRLDFTGVVLTKLDGDTRGGAALSIKSVVNKPIKFIGTGEKMEALDVFYPDRMASRILGMGDVVSLVERAQQQFDEKQAAELQKKIRKNKFDFNDFKSQIQQIKKMGNMKDLMGMIPGVGKALKDVEVDDNAFKPIEAIIDSMTPFERENPDAIDQKRRIRIAKGSGTDINEVNKLMKQFGDMRKVMKQMSNPAMAAKMMRNMPKMPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMW4</accession>
    <name>D7VMW4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance MFS transporter, drug:H+ antiporter-2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_12334</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992839.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12334"/>
    <dbReference type="EnsemblBacteria" id="EFK57261">
        <property type="protein sequence ID" value="EFK57261"/>
        <property type="gene ID" value="HMPREF0766_12334"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_10"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="472" mass="49655" checksum="02E70A11FA9FEC4D" modified="2010-10-05" version="1">MKNTSPLEQSTPYSKRWAALFLLCTAEFLVIMDTSIIGVALPAIKADLGYTQTGLQWIFNAYVILFGGFLLLGGRLSDLFGARKIFMWGFVILTLASLLAGVAWSEATLNIGRALQGLGSAFIAPAALTLVLSKFTDPKELNKALGFWGASAAAGGSAGVFLGGAITEWLSWHWIFLINIPVGIIVLLRSPSLLFTGEKRKGKVDMAGAILATASLILMVYAIVSSESEGWGSVHTIGLLVLSIALLIAFYILQKQKSEPLVPMSIFKVPNLSAGNIVMALLAAAWIPLWFFLNLYLQQTLHYSAFNSGLALLPMTLAIMFLMVGVTGKLVAKFGFKSNMIVGLLALAGSLILFSLVPSDGTFVANVLPASLLGAVGMSLTYIPGTVASMSGAKPEETGLASGLVNTSYQVGSALGLAIIVAISAARTNALKMAGEVEAVALNSGFQTAFFSAGIICIVATVIAAVSIRTMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNP7</accession>
    <name>D7VNP7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_12617</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993217.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12617"/>
    <dbReference type="EnsemblBacteria" id="EFK57544">
        <property type="protein sequence ID" value="EFK57544"/>
        <property type="gene ID" value="HMPREF0766_12617"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_15_0_10"/>
    <dbReference type="OrthoDB" id="1533572at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107162" evidence="4">
        <location>
            <begin position="27"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="171"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="241"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="488" mass="54549" checksum="B3924B0B3099A3DD" modified="2010-10-05" version="1">MKTNKINRYITVAVLTSLSIFSQALAQDYPTDSLSYYIQVAIENNPGVKSQKYAHEAYLEKIPQAGAYQDPELSMEAYTMPMEIIGGRSIGNVSLMQMFPWFGTRKAARTEATHMANMQDQQYREAINNLILQVSTQWYTMQKLNEQLKNNQENQVFLKQLEQLAIRKFSAPSSTSQSSVAPVVSSNTPSSPTRSSASSGMGGMSMGGGNSAPATNQNMSMPSGGGMGAMEGGSGSGMSEVLRIQLEIVEIENNIESLHAQIKAEKAKFNALLNREATEKVMLGQEIHKLNFLYSEEEALRVIEANNPMLEMIAEEGLAFKAKAEMDRKMSYPMIGIGVEYMVVGRTNNSMLAMDGMNGKDMVMPMVSVSLPLFRKKYNAQQNESRLWRKSSEENFKNTFNTLKSEFYSLKSQLDDAQRAIELYEKQTTLAQTTYNLIVKEFVTGKSDLTNVIQVQRQLLDYQLRKAEALANYNTMVVSIKKLLADHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNX4</accession>
    <name>D7VNX4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urease accessory protein UreG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">ureG</name>
        <name evidence="6" type="ORF">HMPREF0766_12694</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993342.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12694"/>
    <dbReference type="EnsemblBacteria" id="EFK57621">
        <property type="protein sequence ID" value="EFK57621"/>
        <property type="gene ID" value="HMPREF0766_12694"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072144_1_0_10"/>
    <dbReference type="OrthoDB" id="1134430at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="PTHR31715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 4" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="5">
        <location>
            <begin position="8"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK57621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="203" mass="22509" checksum="496D3BF7E518642D" modified="2010-10-05" version="1">MDRKYVKIGVAGPVGSGKTALIERLTRQMATDYSICVVTNDIYTREDAQFLQKNSTLPAERISGVETGGCPHTAIREDASMNIEAVEELVQRFPDTEIVFVESGGDNLTATFSPDLADITIFVIDVAEGEKIPRKGGPGITRSDLLLINKIDLAPYVHADLSVMERDAKRMRGERPFIFTNLMTLEGLEDVKSWIKKYALLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP70</accession>
    <name>D7VP70_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_12790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993502.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12790"/>
    <dbReference type="EnsemblBacteria" id="EFK57717">
        <property type="protein sequence ID" value="EFK57717"/>
        <property type="gene ID" value="HMPREF0766_12790"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_3_0_10"/>
    <dbReference type="OrthoDB" id="406005at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="36"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="330"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="475" mass="53361" checksum="892408C93B414CAA" modified="2010-10-05" version="1">MLNSKIMKRNIMLFKKIVWTIILPVSLLSFLACNELDIKPTDGIDPDKAFRNLEDIDMGIKGAYAAIDYTLIENNVTVSDEAIMPAENVVSNTNAYRWLYTASSSSVTSAFREYYIVIDRTNRVLTGLEKLTNVDETKKGHYRGELLAIRAYAHLELLRAFSGGYEPANLAIPYMLESKISYPARNTVQEVVNFVKTDLNEALSLIGDEASVSRISKPAVYAILARTALYSKDWPLAISASTAAINAKPLASQQNFARIWTDQSEDEVIWSLKKSEASDSRIGSFLFREDGGIALFAPSSKLLNLFDKDNDIRYSSYITYDPDRGAGKSPYLIKKYVGRSSDAPGLTNIKLFRTGEMYLIRAEAYAETPNQLLGTADLNQLRKSRITGYTDQTFADKEALIREIYTERYKELAYEGHRFFDLKRRNLPVQRSAQDAVNTSGALTLESGKAQYNFPIPATEMSVNKNMIQNPNYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP99</accession>
    <name>D7VP99_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane protein, OMP85 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993574.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12819"/>
    <dbReference type="EnsemblBacteria" id="EFK57746">
        <property type="protein sequence ID" value="EFK57746"/>
        <property type="gene ID" value="HMPREF0766_12819"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010929_0_0_10"/>
    <dbReference type="OrthoDB" id="470487at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Omp85" evidence="2">
        <location>
            <begin position="415"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="778" mass="88691" checksum="C05A85F7352B6B0E" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPC8</accession>
    <name>D7VPC8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase, S9A/B/C family, catalytic domain protein</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12848</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993617.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12848"/>
    <dbReference type="ESTHER" id="9sphi-c2fy52">
        <property type="family name" value="DPP4N_Peptidase_S9"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.013"/>
    <dbReference type="EnsemblBacteria" id="EFK57775">
        <property type="protein sequence ID" value="EFK57775"/>
        <property type="gene ID" value="HMPREF0766_12848"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006105_2_0_10"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107406" evidence="1">
        <location>
            <begin position="23"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="DPPIV_N" evidence="3">
        <location>
            <begin position="79"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="521"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="720" mass="81869" checksum="3409BAD7F38343F3" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPD1</accession>
    <name>D7VPD1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PHP domain protein</fullName>
            <ecNumber evidence="3">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">polB</name>
        <name evidence="3" type="ORF">HMPREF0766_12851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993620.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12851"/>
    <dbReference type="EnsemblBacteria" id="EFK57778">
        <property type="protein sequence ID" value="EFK57778"/>
        <property type="gene ID" value="HMPREF0766_12851"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017729_1_0_10"/>
    <dbReference type="OrthoDB" id="1615112at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="DNA_pol_b-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022311">
        <property type="entry name" value="UCP005047_YshC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005047">
        <property type="entry name" value="UCP005047_YshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="SSF47802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLXc" evidence="2">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="320"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="560" mass="62606" checksum="99EDDAF3B5AA113F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPN1</accession>
    <name>D7VPN1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase, S9A/B/C family, catalytic domain protein</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12951</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993812.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12951"/>
    <dbReference type="ESTHER" id="9sphi-d7vpn1">
        <property type="family name" value="DPP4N_Peptidase_S9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57878">
        <property type="protein sequence ID" value="EFK57878"/>
        <property type="gene ID" value="HMPREF0766_12951"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006105_2_0_10"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107412" evidence="1">
        <location>
            <begin position="19"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="DPPIV_N" evidence="3">
        <location>
            <begin position="125"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="531"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="725" mass="82114" checksum="0CC1D154C2B20030" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPQ5</accession>
    <name>D7VPQ5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">OmpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tpn</name>
        <name evidence="6" type="ORF">HMPREF0766_12975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993851.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12975"/>
    <dbReference type="EnsemblBacteria" id="EFK57902">
        <property type="protein sequence ID" value="EFK57902"/>
        <property type="gene ID" value="HMPREF0766_12975"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014978_1_0_10"/>
    <dbReference type="OrthoDB" id="583204at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107492" evidence="4">
        <location>
            <begin position="19"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="5">
        <location>
            <begin position="515"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK57902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="628" mass="70418" checksum="BFC7001A628A3D80" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPW4</accession>
    <name>D7VPW4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14324"/>
    <dbReference type="EnsemblBacteria" id="EFK57121">
        <property type="protein sequence ID" value="EFK57121"/>
        <property type="gene ID" value="HMPREF0766_14324"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071330_5_4_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="153" mass="17084" checksum="B327ABB9EDFF7349" modified="2010-10-05" version="1">MTGYDGCFFCAGVSSVGENEESFTKKTYDFVIPFARTLSAINPEMIFIYVSGNRTDSTEQGKVMWARVKGRTENELMKLPFKGQYNFRPAIMKATKGQVNVKTIYRIMGPLIAPFISAKTLKLADVGRAMIHAVSKGYPKQVLEVDDIIQLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPY0</accession>
    <name>D7VPY0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin-like protein</fullName>
            <ecNumber evidence="2">1.6.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yheR</name>
        <name evidence="2" type="ORF">HMPREF0766_13034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993942.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13034"/>
    <dbReference type="EnsemblBacteria" id="EFK55831">
        <property type="protein sequence ID" value="EFK55831"/>
        <property type="gene ID" value="HMPREF0766_13034"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058643_0_2_10"/>
    <dbReference type="OrthoDB" id="1143659at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="197" mass="22905" checksum="C6767181C0A58CC8" modified="2010-10-05" version="1">MLKILVLFAHPTLEQSVVNKKLIRRMRSLPDISVRDLYELYPDFDIPVRVEQAALERHDIVIWMHPIYWYSAPPIIKQWIDLVLLHDWAYGARGTALKDKWIFNAVTTGATLEAYQEGGHHGYPLKDFLLPYKQTAALCHMHYLPPYVIDGTFSKQPKEIEQDIEQFISHLQLLQSGKFEAAALQQFSYLNQLKDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ04</accession>
    <name>D7VQ04_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13058</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993975.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13058"/>
    <dbReference type="EnsemblBacteria" id="EFK55855">
        <property type="protein sequence ID" value="EFK55855"/>
        <property type="gene ID" value="HMPREF0766_13058"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_1_3_10"/>
    <dbReference type="OrthoDB" id="1031920at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="3">
        <location>
            <begin position="53"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK55855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="252" mass="29517" checksum="FD893C237D486B42" modified="2010-10-05" version="1">MDIFYSPLLYLFVILVLIVAIVILIIRNKRQQEHFNTIEQRYKDLEKKVDGFQLKNLEAKLQPHLFKNILNSVQSHAYQTYYTLDKLATVLDYVLYEARDEFVTVRREIDFAKSLIDINKIKVSPLFEIKVKTKIAGHNPYYEQKLIVPMICLDLIENAFKHSDLQSPDAFISFYFELSEEGIFGITVSNTSSELKPLSKQAGGLGMEAFEQRLRILYKDCFKLERFLEGNIYTAYLKLDLKQIERAKMYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ87</accession>
    <name>D7VQ87_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994094.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13141"/>
    <dbReference type="EnsemblBacteria" id="EFK55938">
        <property type="protein sequence ID" value="EFK55938"/>
        <property type="gene ID" value="HMPREF0766_13141"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004155_0_1_10"/>
    <dbReference type="OrthoDB" id="616258at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_11" evidence="2">
        <location>
            <begin position="285"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_12" evidence="3">
        <location>
            <begin position="841"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK55938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1017" mass="117042" checksum="CE8070A95E38DE08" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQB6</accession>
    <name>D7VQB6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ThiF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiF</name>
        <name evidence="2" type="ORF">HMPREF0766_13170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994164.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13170"/>
    <dbReference type="EnsemblBacteria" id="EFK55967">
        <property type="protein sequence ID" value="EFK55967"/>
        <property type="gene ID" value="HMPREF0766_13170"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_10_0_10"/>
    <dbReference type="OrthoDB" id="1408716at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="10"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="236" mass="26114" checksum="D36B30C08CEB3029" modified="2010-10-05" version="1">MLPREEILRYKKHIMLPEIGIEGQEKIRNARILVVGSGGLGSPILSYLTGAGVGTIGIIDFDRIEKDNLHRQILFTESDLKKDKVTTAILKLQQHNSGIQFIAHNLKLDSSNASQIFEAYDLIIDGSDNFATRYLSNDTCVSIGKPLIFGSVLNFQGQVAVFNHKGSKNLRDLFPVPPPAEDVPNCDENGVIGTLPGIIGCMMAQEALKLITGLPTLHNEFVLFDTLQLQMRKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQC0</accession>
    <name>D7VQC0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiamine monophosphate synthase/TENI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994174.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13174"/>
    <dbReference type="EnsemblBacteria" id="EFK55971">
        <property type="protein sequence ID" value="EFK55971"/>
        <property type="gene ID" value="HMPREF0766_13174"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018272_4_0_10"/>
    <dbReference type="OrthoDB" id="1558094at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TMP-TENI" evidence="1">
        <location>
            <begin position="47"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="198" mass="22484" checksum="02C5C1BD03612EB0" modified="2010-10-05" version="1">MIIISPDTITPQHIKLIHAIPWSDALLYHLRLPSAAKDDITPILEDIDKHLYPFIVLHYHKETALKAGIRRFHLSGDRIKDIEQSQTDLILSASTHQINEFNSLDTRISYAFISPVYPSISKVGYQATADFKSHNIQHRTNFNCRMIALGGITEYNISELKAMGYDDIALCGYIWKHPDPLFAADKCLSISQTTSYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQI0</accession>
    <name>D7VQI0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13234"/>
    <dbReference type="EnsemblBacteria" id="EFK56031">
        <property type="protein sequence ID" value="EFK56031"/>
        <property type="gene ID" value="HMPREF0766_13234"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2958443_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="59" mass="7186" checksum="11C5A98DD21E17A7" modified="2010-10-05" version="1">MHIISNLWPLFNLALIVFIIFIVYYLALVFTKRFLKLYQERNEYLKEIADHLKVISNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQJ0</accession>
    <name>D7VQJ0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, DeoR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_13244</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994327.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13244"/>
    <dbReference type="EnsemblBacteria" id="EFK56041">
        <property type="protein sequence ID" value="EFK56041"/>
        <property type="gene ID" value="HMPREF0766_13244"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060699_2_1_10"/>
    <dbReference type="OrthoDB" id="1629121at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="249" mass="27514" checksum="7F2EA53EFD7C580F" modified="2010-10-05" version="1">MLKEERFDHILTVLRDAGKVGYTPLSADLSVSEDTIRRDIDTLADRGLLVKVRGGAILPAKNPLNFQDRSSYFTTEKEIIALKTQPFIKAGQTIFMDGGTTICEIAAHLPTHSNFRVITNNQALIPLLSVYKGIEIIVLGGIYNRETQVNSGLQTCEEVCSYVADLYLMGACAIQYQYGITAGTKEERDLKQAMLKSSLQQIVVSHTDKLNSTYPFKVCDVSDVDTLITEAASDDKRLDDFRGSGIQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQK4</accession>
    <name>D7VQK4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative manganese transport protein MntH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_13258</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994358.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13258"/>
    <dbReference type="EnsemblBacteria" id="EFK56055">
        <property type="protein sequence ID" value="EFK56055"/>
        <property type="gene ID" value="HMPREF0766_13258"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1914">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020088_6_3_10"/>
    <dbReference type="OrthoDB" id="416257at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="PTHR11706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="410" mass="43994" checksum="46A67E8B91138C71" modified="2010-10-05" version="1">MSTQPTNTPKTKINWLSVLGPGIITAALVFGPSKMTITSKMGADYGYDLLWVIILAIFFMMVFTTMAARIGAQNSESLLTLIKNKFGKPVAIFIGLGIFLVAISFQSGNSTGVAISVGEATGSNPKIWIVVFNVLGILLLFFRSFYKVLEKLMLVLIIIMLFSFLTTAILVQPNLIDMSKGIIPGIPDGSMVLIIAFIASCFSLVGAFYQSYLVQERKKMGGSDQQNGTEMLGSRVGIIILGIMSTGVLVCAANILHPQGIKVNSATEMGKALEPLFGDYASQLFYIGLFGASFSSLIGNAVLGGSLLGDTFGYGNNLNNKMVKLFISIVMIFGSIIALAFGKLPLELIVFAQSITTLLVPFIGFTLYLIGNDKTLMKERVNSTSTKIWGALGLILIIGLAVSNLITLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQL2</accession>
    <name>D7VQL2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13266"/>
    <dbReference type="EnsemblBacteria" id="EFK56063">
        <property type="protein sequence ID" value="EFK56063"/>
        <property type="gene ID" value="HMPREF0766_13266"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3122804_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="50" mass="6128" checksum="BA25A084EFA8B0E6" modified="2010-10-05" version="1">MNNVIKKGIRQYLFFKDLWLYIFYLLKQINKPDFLSTKKKSGINNLKQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQU9</accession>
    <name>D7VQU9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13353"/>
    <dbReference type="EnsemblBacteria" id="EFK56150">
        <property type="protein sequence ID" value="EFK56150"/>
        <property type="gene ID" value="HMPREF0766_13353"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3296706_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="40" mass="4793" checksum="7C00720D87455212" modified="2010-10-05" version="1">MFFVLYILSFPYAKAGRHQFPKKKAEYILESVHLYRSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR54</accession>
    <name>D7VR54_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13458"/>
    <dbReference type="EnsemblBacteria" id="EFK56255">
        <property type="protein sequence ID" value="EFK56255"/>
        <property type="gene ID" value="HMPREF0766_13458"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2976964_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="58" mass="6543" checksum="39812D1CF130388B" modified="2010-10-05" version="1">MHIELGSGFNFGWVIIAIAVIMAGGIYISYRKNYPIKIKYIIAVIIMLIVGVKFILEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR62</accession>
    <name>D7VR62_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-dependent receptor plug domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_13466</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13466"/>
    <dbReference type="EnsemblBacteria" id="EFK56263">
        <property type="protein sequence ID" value="EFK56263"/>
        <property type="gene ID" value="HMPREF0766_13466"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012669_1_0_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="127"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="275"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="758" mass="85532" checksum="4E8ACE36730A9ED1" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRG9</accession>
    <name>D7VRG9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994765.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13573"/>
    <dbReference type="EnsemblBacteria" id="EFK56370">
        <property type="protein sequence ID" value="EFK56370"/>
        <property type="gene ID" value="HMPREF0766_13573"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072057_0_0_10"/>
    <dbReference type="OrthoDB" id="1635603at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033395">
        <property type="entry name" value="DUF5106"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17127">
        <property type="entry name" value="DUF5106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5106" evidence="2">
        <location>
            <begin position="55"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="1">
        <location>
            <begin position="193"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="310" mass="35630" checksum="3442AF40DE87B9B0" modified="2010-10-05" version="1">MKNTYLSGIGLIIFLLVVFDSCNNGHTRKQEEKLDTIDSMNTNAVSSVRKLAIGNFWDDFDFNDEEFYKRDGEQAIADFIGLFPSSSPEEIQKAVFRMLSKAESNPQAFAFFQGLFKKYLYDPNSPLRNDMYYEPVIGYLIHSDKVSAIEKNTYEQLLKTVKKNKVGTAATSFSVALQSGREVRLEEIDAPFLLLIFYEPDCNSCKSIIEKMKNIPELNELIDNKKLLKILAVYAVGNEEIWKDYFPYMPGNWINAIDKNKHIITRNLYDLKASPTMYLLDQRKHVILKDSDLGHVMYFLTNNKGLTSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRZ9</accession>
    <name>D7VRZ9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease H</fullName>
            <ecNumber evidence="5">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rnhA</name>
        <name evidence="7" type="ORF">HMPREF0766_13753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995185.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13753"/>
    <dbReference type="EnsemblBacteria" id="EFK56550">
        <property type="protein sequence ID" value="EFK56550"/>
        <property type="gene ID" value="HMPREF0766_13753"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030894_6_2_10"/>
    <dbReference type="OrthoDB" id="1953872at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09278">
        <property type="entry name" value="RNase_HI_prokaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022892">
        <property type="entry name" value="RNaseHI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="166" mass="18844" checksum="42E28DE05BE78B8C" modified="2010-10-05" version="1">MIELYTDGASSGNPGPGGYGTILRTRYSGENEAFKGKLIEKTFSEGFRRTTNNRMELMAVIIGLEALKSPQQQVTIYSDSKYVIDAIDKKWVYGWIQKGFQGKKNKDLWIRLMKSYKLHQVRLVWVKGHAGHPDNERCDQLAVAASKDKANWKIDAVFEQEEKALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS74</accession>
    <name>D7VS74_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995368.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13828"/>
    <dbReference type="EnsemblBacteria" id="EFK56625">
        <property type="protein sequence ID" value="EFK56625"/>
        <property type="gene ID" value="HMPREF0766_13828"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032S7H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1151222_0_0_10"/>
    <dbReference type="OrthoDB" id="1900805at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107234" evidence="1">
        <location>
            <begin position="26"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="241" mass="26800" checksum="F0D128A9E921CBF8" modified="2010-10-05" version="1">MKKHTFYLMICFVLSSFLLSSCLKDDDNNYIDIPAGGLTMINGFSDAQGIVYYADQRAVQNPYFPLMYKGYDWVGLFTGNRNIIVKGTQDPKTLVDTTFAVKDSVYYSSFTFGNKDKAKHFITEDKKMSITSGTEKQTGLRFFNLADMPGKVSLQIGDAALNDKFKDRATETQTTATANQIFLPQASGTFKLSVKDESGTVLVSRDGIKLDPDNYYSIILVGKKDNTNTPLYIGVVKQAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS82</accession>
    <name>D7VS82_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-galactosidase</fullName>
            <ecNumber evidence="4">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HMPREF0766_13836</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995396.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13836"/>
    <dbReference type="EnsemblBacteria" id="EFK56633">
        <property type="protein sequence ID" value="EFK56633"/>
        <property type="gene ID" value="HMPREF0766_13836"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009998_0_0_10"/>
    <dbReference type="OrthoDB" id="245411at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107867" description="Beta-galactosidase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="11">
        <location>
            <begin position="51"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="9">
        <location>
            <begin position="183"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="10">
        <location>
            <begin position="296"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Bgal_small_N" evidence="12">
        <location>
            <begin position="690"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFK56633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="963" mass="108968" checksum="F6A6ABD72748E77E" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSD9</accession>
    <name>D7VSD9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13893"/>
    <dbReference type="EnsemblBacteria" id="EFK56690">
        <property type="protein sequence ID" value="EFK56690"/>
        <property type="gene ID" value="HMPREF0766_13893"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZCBZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1522848_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107622" evidence="1">
        <location>
            <begin position="21"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="175" mass="19837" checksum="81FAC2A82D5DF32C" modified="2010-10-05" version="1">MKYCIILASFLVLSGCKTNAQKLNVTTIYSETDRVTKEVPETGAVHTYTTRKEVTKRLNPMIVMTSKNAEILKFRIQGNISSGGLNINKIRKIRFEKGQQNGNNITLRYFAEVKKIPGKEGSDVVGYNYTKDETYKIPGDVKIIKIELYEDRIKNTSGTTPKLIAEQTFNFFAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSE7</accession>
    <name>D7VSE7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995535.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13901"/>
    <dbReference type="EnsemblBacteria" id="EFK56698">
        <property type="protein sequence ID" value="EFK56698"/>
        <property type="gene ID" value="HMPREF0766_13901"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1843846_0_0_10"/>
    <dbReference type="OrthoDB" id="1962921at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="139" mass="15613" checksum="177E99845FD6AF57" modified="2010-10-05" version="1">MNKIIPNISMHYKRYFFVFAAILLVLLTSCVVKTSIKNLAGIPVKTEQSIPKGTQNFSANAIEKCAQSDASDKQIVQKKSFDANDLLPAVIFTITCLFLYALQPVSKESKHPLYSDSGKIHSSIPIFLEYRKLILHYTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSG6</accession>
    <name>D7VSG6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_13920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995570.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13920"/>
    <dbReference type="EnsemblBacteria" id="EFK56717">
        <property type="protein sequence ID" value="EFK56717"/>
        <property type="gene ID" value="HMPREF0766_13920"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_4_1_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014327">
        <property type="entry name" value="RNA_pol_sigma70_bacteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02985">
        <property type="entry name" value="Sig70_bacteroi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="124"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="200" mass="23883" checksum="3317813F9C1BF69E" modified="2010-10-05" version="1">MKYPVPEKQILLALKNGNERAFERIYEQYFQSVYLFVQGYVKSPDLAQDICQEIFMKVWDNRERFVKVLSFRHYLFTLAKNHTLNHLRAISRSNVSMQELLRYYPLEEQTTGNSLQEKEYEKFIQRAFENLSPTAKQVFDLCREKQMTYDQVAKEMGFSRDAVKKYMVQTMKTFRSLISGPLDIHFCVLLCFSVDYILFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSG8</accession>
    <name>D7VSG8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SusD-like_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995572.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13922"/>
    <dbReference type="EnsemblBacteria" id="EFK56719">
        <property type="protein sequence ID" value="EFK56719"/>
        <property type="gene ID" value="HMPREF0766_13922"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2956">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_3_0_10"/>
    <dbReference type="OrthoDB" id="758760at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SusD-like_3" evidence="1">
        <location>
            <begin position="22"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="441" mass="50029" checksum="74A9BFE1BDC08190" modified="2010-10-05" version="1">MKKYTTYLCLFLMGTVFSSCDKYLDIQPVGTVVPKTEADFRALMTSGYQSFPAQKSYLNLRTDELALDENSTDLAAIRDLHLWNDRNPDATTLPYAWLSFYKTIFYANHVISKAEEAAGNTDAVQQIRAEAYLMRAYSHFELLNSYAEQYNAGTAATDKGVPISITIDLEQKFPAATVAAVYKQIEADMQAGNALLNVSDQPAAVKYRFSKRSYYAFESRLRLYKGEWKVAMDAAEKALAIKADLVDLNKTGSVLPNDFESAEMIQAWEEVGKSNVSTSTFISSKLLGLYNQKDDLRFARYFGKQGSRNYVSLKGGNIRYNVSFRNAELYLIIAETAARLGDRPKAISALTTLLKNRLTPTYFATRNAELNAMPDAELLKEIITERARELALEGLRWNDMKRTDRPEVIHTFFGKEYRLIQNDPRYVIRYPKEAIEKNPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSI8</accession>
    <name>D7VSI8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, Spx/MgsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">arsC</name>
        <name evidence="2" type="ORF">HMPREF0766_13942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArsC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995595.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13942"/>
    <dbReference type="EnsemblBacteria" id="EFK56739">
        <property type="protein sequence ID" value="EFK56739"/>
        <property type="gene ID" value="HMPREF0766_13942"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116644_2_1_10"/>
    <dbReference type="OrthoDB" id="1606021at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006504">
        <property type="entry name" value="Tscrpt_reg_Spx/MgsR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01617">
        <property type="entry name" value="arsC_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="115" mass="13398" checksum="845FF19D21F640F7" modified="2010-10-05" version="1">MLHVYGIKNCNTVKKALDYLTNHKLDYTFHDFKKEGVSDEQLKKWEKQVDWEKLVNKKGTTWKKLTDEEKEAVTDAVSANKTLIANTSMIKRPVIEYTSGLILGFDEDEYNLKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSJ2</accession>
    <name>D7VSJ2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TrkA N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995599.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13946"/>
    <dbReference type="EnsemblBacteria" id="EFK56743">
        <property type="protein sequence ID" value="EFK56743"/>
        <property type="gene ID" value="HMPREF0766_13946"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2910">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_3_1_10"/>
    <dbReference type="OrthoDB" id="948454at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="2">
        <location>
            <begin position="7"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="216" mass="23358" checksum="0ADE9074E3E6FE1F" modified="2010-10-05" version="1">MKVALIGASGYVGSHILKELVHRGHHVTAIARNTDQIEKNEHILAVQNDVNDSNALAAILKGSDAVISAYNAGWTNPSIYEDYTAGARSIQEAVEHAGIKRFIVIGGAGSLLTEAGTRIVDAPDFPAEIKPGALAAADYYEVIRRSNDLDWTLFSPAIEMSPASPGTRTGTYRTDLDHPVTDQEGRSRLSVEDVAVAIVDELEKPQFIKKRFTAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSJ7</accession>
    <name>D7VSJ7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995605.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13951"/>
    <dbReference type="EnsemblBacteria" id="EFK56748">
        <property type="protein sequence ID" value="EFK56748"/>
        <property type="gene ID" value="HMPREF0766_13951"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z85F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066824_2_0_10"/>
    <dbReference type="OrthoDB" id="959247at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032315">
        <property type="entry name" value="DUF4846"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16138">
        <property type="entry name" value="DUF4846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107888" evidence="1">
        <location>
            <begin position="22"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="287" mass="32839" checksum="49615270C06C7BF0" modified="2010-10-05" version="1">MMLHFFHTLLLIPSLILSATACQSGSGNAESDIANRDSLPSENYVSDEGYNTAWINSEGATVKDRFITPDGYQRKAYKAGEFGYFLQHLPLKKMGSEVLYYNGNVKAQNKIYVSVVNLPIGTRDLHQCADAVMRLRADYLYQQKRFKEIHFNFLSDAKPRYYTDYIKGDYSAKKYWKYMEYIFAYANTASLHDELPAVSSVRNIKIGDTFIQKGNPIGHAIIAVDMAENEQGEKLVLLAQSYMPAQEIQILNNPNDPKLSPWYKLKDGVILTPEWKFKSENLKTWKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSV4</accession>
    <name>D7VSV4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_14058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995836.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14058"/>
    <dbReference type="EnsemblBacteria" id="EFK56855">
        <property type="protein sequence ID" value="EFK56855"/>
        <property type="gene ID" value="HMPREF0766_14058"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_2_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="153"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="471"/>
            <end position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1092" mass="120426" checksum="93C23203EA5CF3F0" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSZ9</accession>
    <name>D7VSZ9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14103"/>
    <dbReference type="EnsemblBacteria" id="EFK56900">
        <property type="protein sequence ID" value="EFK56900"/>
        <property type="gene ID" value="HMPREF0766_14103"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_962796_0_0_10"/>
    <dbReference type="OrthoDB" id="1684711at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032774">
        <property type="entry name" value="WG_beta_rep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14903">
        <property type="entry name" value="WG_beta_rep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107263" evidence="1">
        <location>
            <begin position="22"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="289" mass="33137" checksum="6934EB1133E768AC" modified="2010-10-05" version="1">MRSIRTLLILITVFLQVYVNAQTDPVLVPVNDRKQGYIGYYLEDGTEVVPPQFCTATYLIEDKYYIVSRAEHDHYPDGRRKEEHIPNTEKYGLLNSKGKVIIPLDNNYSFVSVNNGVITVGKNNTYGVVDEENKITVPLIYTSLDPIDANLIVAERNNKAGIIDIHNNVKVAFEFDRIYPFEKGSDGSLLAMAEIAHKTAVIDPTGKYILQPSDIYVSYLTPVSFVFKEGEHYGLMDYRKKVLIPAMYTDVYKTENELQFRKDDNYYYFSFGGKLIRKEKIEESYKSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT19</accession>
    <name>D7VT19_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995970.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14123"/>
    <dbReference type="EnsemblBacteria" id="EFK56920">
        <property type="protein sequence ID" value="EFK56920"/>
        <property type="gene ID" value="HMPREF0766_14123"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZNYX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152424_0_0_10"/>
    <dbReference type="OrthoDB" id="1412738at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="136" mass="16246" checksum="5C8B991150B59E3E" modified="2010-10-05" version="1">MKALHKMDNLDKGELLCRLFPEEMANIQNAVKKQCEYFLKNEITIREGWYQKGFFTAEFWYRLVQDAHRIIEKNEDKLLKKPRWFADHFFDGYNAIFAMHCLIEYAQTEDCKPNLKQAIHLIFGSEPLLKITLNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT26</accession>
    <name>D7VT26_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995992.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14130"/>
    <dbReference type="EnsemblBacteria" id="EFK56927">
        <property type="protein sequence ID" value="EFK56927"/>
        <property type="gene ID" value="HMPREF0766_14130"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031685">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2435514_0_0_10"/>
    <dbReference type="OrthoDB" id="1783468at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="93" mass="10988" checksum="BF265A9C00E339E6" modified="2010-10-05" version="1">MVASLVIGIIFLVAGLGLRYWINRRKFYRRSPMGAEGFSSYESSVFIKFVERVGKWIAYGLIIFGLLSLWVYWREKKEKQQPEVKIEQPAERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT51</accession>
    <name>D7VT51_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Relaxase/mobilization nuclease domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996040.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14155"/>
    <dbReference type="EnsemblBacteria" id="EFK56952">
        <property type="protein sequence ID" value="EFK56952"/>
        <property type="gene ID" value="HMPREF0766_14155"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044309_0_1_10"/>
    <dbReference type="OrthoDB" id="1134905at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005094">
        <property type="entry name" value="Endonuclease_MobA/VirD2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03432">
        <property type="entry name" value="Relaxase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="426" mass="48562" checksum="53F939618E99C285" modified="2010-10-05" version="1">MIAKIGRSGNLYGALAYNNLKIEKENGQILFANKMIETASGQYTVAQLAQSFAPYLIANRNTEKHTLHISLNPDPKDIVNDDKFREMAQQYMREMGYGEQPFIVFKHTDIDRSHIHIVSVCVDEQGKKISDKFEKMRSMNVCRELEKQYHLIPATDKERNQTDKVFRPVDYRAGDVKSQIASVVRHLPNYYKFQTLGEYNALLSLFNVTTEKVEGELQGKMRQGLLYIPLNEKGERAGHPFKASLFGKNAGLPALELHFAKCKEDLKDHPSKQTLKAAISIALKSTNDEQAFKKQLSEQGINVVVRRNDTGRIYGITFIDHNSKAVWNGSRLAKELSANTFNDYWNNNIKPEIKEPVVQLPKTSTSNDADLPAEEPHHLFDFLNTTEKHEDGLIEAFGGLLPEAQGDDYEEQDFANKMKKKKKRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT64</accession>
    <name>D7VT64_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase C-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14168"/>
    <dbReference type="EnsemblBacteria" id="EFK56965">
        <property type="protein sequence ID" value="EFK56965"/>
        <property type="gene ID" value="HMPREF0766_14168"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4646">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000181_10_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="656"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="360"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1112" mass="126924" checksum="8DF872FDFE4C448A" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT99</accession>
    <name>D7VT99_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Beta-N-acetylhexosaminidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">N-acetyl-beta-glucosaminidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hex</name>
        <name evidence="9" type="ORF">HMPREF0766_14203</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996160.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14203"/>
    <dbReference type="EnsemblBacteria" id="EFK57000">
        <property type="protein sequence ID" value="EFK57000"/>
        <property type="gene ID" value="HMPREF0766_14203"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007082_4_1_10"/>
    <dbReference type="OrthoDB" id="727559at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004866">
        <property type="entry name" value="CHB/HEX_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004867">
        <property type="entry name" value="CHB_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03173">
        <property type="entry name" value="CHB_HEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03174">
        <property type="entry name" value="CHB_HEX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SMART" id="SM01081">
        <property type="entry name" value="CHB_HEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107660" description="Beta-N-acetylhexosaminidase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="CHB_HEX" evidence="8">
        <location>
            <begin position="29"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK57000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="857" mass="97652" checksum="6B1CEC754AB5D471" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTA1</accession>
    <name>D7VTA1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, LacI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_14205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996168.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14205"/>
    <dbReference type="EnsemblBacteria" id="EFK57002">
        <property type="protein sequence ID" value="EFK57002"/>
        <property type="gene ID" value="HMPREF0766_14205"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_0_1_10"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="352" mass="40001" checksum="8A3E7FFD282FA042" modified="2010-10-05" version="1">MKKDNSLVGIKELAKLANVSIGTIDRVLHDRPGVAAKTKERVLAVLQEHDYQPNMIARALASRKARRIVVLIPSASPESAYWKAPLEGVRTAGSEIQRYSFTLDVLLFDQNDRHSFIPLAMQLLEEDFDALVLAPMFHQEAQPLLQHCDENKIPYVFINSDIPGSDSAAYFGPDLFQSGCMSAQLINYISNPADEILLVHISREMEMQHHLLRKEEGLLQYMQDNGMKQKLHKLVIRDTTYSAIEQALAEQLKNTTIQVLFVTNSRVASVARFIEEQQVAGICLIGFDYLPDNIAYLEKGIIDFLLCHKPVAQGYKSVMSLFQLLEAQQEPQKINYMPIDIISKENYRYYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTE6</accession>
    <name>D7VTE6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14250"/>
    <dbReference type="EnsemblBacteria" id="EFK57047">
        <property type="protein sequence ID" value="EFK57047"/>
        <property type="gene ID" value="HMPREF0766_14250"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2791855_0_0_10"/>
    <dbReference type="OrthoDB" id="2097982at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="73" mass="8777" checksum="2F216446E95C1A1D" modified="2010-10-05" version="1">MGFQSLEIRELKTYFESHEIPYEIMLPKNVHIRDVKGFINVCFEYIEDWGVELEKCPLWIKLLEIKMILDSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTF6</accession>
    <name>D7VTF6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytosol aminopeptidase family, catalytic domain protein</fullName>
            <ecNumber evidence="7">3.4.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pepA</name>
        <name evidence="7" type="ORF">HMPREF0766_14260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996321.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14260"/>
    <dbReference type="EnsemblBacteria" id="EFK57057">
        <property type="protein sequence ID" value="EFK57057"/>
        <property type="gene ID" value="HMPREF0766_14260"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013734_6_0_10"/>
    <dbReference type="OrthoDB" id="356206at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="6">
        <location>
            <begin position="147"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="461" mass="51703" checksum="201CAA407E7B9EF1" modified="2010-10-05" version="1">MSKLIQHIYIYSEVSWTAHKPVYPDAMDKFFSGKQHESFVITSEKEITWFLGIGNSSCTESVLVDIGQKFAYDNREKLLPTSTYLHHDLLDSPGFESLWMGFYLGTYEYPFKATHPLWDDRFKWEGLQDHKAGLTKIKSICEGQFMCMDWLNKPANFKRTTLLNAFLKEKSREYELQYTSFNRKECEIHGLGAFLAVNQGSSQEASFTIMEYRCGTKGAPVIGLVGKCVLFDTGGISIKPSANLHYMKSDMGGATAILGALIAVSKMKFPVDIVAILPITDNAVSNNSYLPSDVVTAYNGNTIEILDTDAEGRLTLADGLSYLSKNYKTDYLIDLVTLTGSAVRMFGSTCGALFSNNEALEQQLLKSGQKTGQRLWNLPLWEDWEDEIKSDVADFKNISLKPVGDCIVAATFLKHFINEHPKWAHLDIAAMCFGNVRYAKEKAATGYGVRLLIDFIENLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTI1</accession>
    <name>D7VTI1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996384.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57082">
        <property type="protein sequence ID" value="EFK57082"/>
        <property type="gene ID" value="HMPREF0766_14285"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50349I4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2002451_0_0_10"/>
    <dbReference type="OrthoDB" id="1933178at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="103" mass="11656" checksum="4055041E7B6DA533" modified="2010-10-05" version="1">MKDTVYATLKSDFEKFMRHSIHVSGAFGFDVFGDYVTSVLNFYVGSSVLTLDEKVNAAFYLCQLYNKGLKNMMSVADMKEMSIEFANDPTLDYTVLSPIFDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTR5</accession>
    <name>D7VTR5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14385"/>
    <dbReference type="EnsemblBacteria" id="EFK55824">
        <property type="protein sequence ID" value="EFK55824"/>
        <property type="gene ID" value="HMPREF0766_14385"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080100_0_0_10"/>
    <dbReference type="OrthoDB" id="1155935at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009722">
        <property type="entry name" value="SdiA-regulated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06977">
        <property type="entry name" value="SdiA-regulated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107392" evidence="1">
        <location>
            <begin position="24"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="298" mass="33606" checksum="B5E551630CB1DBD6" modified="2010-10-05" version="1">MTPMNRPVFILSLALSLSSYAFQACSQKANTTKTKETATPATDKTIPYQLDKGQPTELPDELQEISGITFLPDNKEWIYAIQDEKGLLYSYNLINKQLSSVPFEKDGDYEDLAVSKSHFIILKSNGTLYTFPISEKNNIQQVKTFKDILPKGEYEGLATDTVRQLVFALCKSCSADKKKAQTSGYIFKINETGDLEANGGFTLNINQLKQFDSSFSKTFKPSALTKRVSTNEWYILSSVDKALVITDDKWNIKSVFLLSRKQHTQPEGIAFDTDDNLYISNEAGNKDKAILYKFKLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTW5</accession>
    <name>D7VTW5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative magnesium and cobalt transport protein CorA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">corA</name>
        <name evidence="7" type="ORF">HMPREF0766_14435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002281.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14435"/>
    <dbReference type="EnsemblBacteria" id="EFK55744">
        <property type="protein sequence ID" value="EFK55744"/>
        <property type="gene ID" value="HMPREF0766_14435"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_0_0_10"/>
    <dbReference type="OrthoDB" id="822653at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK55744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="301" mass="35766" checksum="4AFC0B194FF50BD3" modified="2010-10-05" version="1">MIEVLIEDDCIPFVWIDISNPSREDFKDLAPRYNLNEASIKDCLEIGHLPKIEEFDTYHFLIIRSVANSFDENSDSMTDITDRVSIFFNEKFVITVHRNEVEYLNNIKKADRKGKKFASTKALMNFITSESLKTFENLAMNGLSERLDDYEGIVFLHSKRKLFLKRLYYLKRQIDVIRNILAICKDIVDYFHMPEYKNIYTQDLRDLYLRNSTLYRNLSENTSQLLSVYFNIESNHTNEIMRTLTIISVFFMPLTFIAGIYGMNFKNMPELEWYYGYPLSLGMMAFVAAVIYIWFKRKRWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTW8</accession>
    <name>D7VTW8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease P protein component</fullName>
            <shortName evidence="6">RNase P protein</shortName>
            <shortName evidence="6">RNaseP protein</shortName>
            <ecNumber evidence="6">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">rnpA</name>
        <name evidence="7" type="ORF">HMPREF0766_14438</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RnpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002284.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14438"/>
    <dbReference type="EnsemblBacteria" id="EFK55747">
        <property type="protein sequence ID" value="EFK55747"/>
        <property type="gene ID" value="HMPREF0766_14438"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0594">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117179_1_0_10"/>
    <dbReference type="OrthoDB" id="2014742at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020539">
        <property type="entry name" value="RNase_P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00648">
        <property type="entry name" value="RIBONUCLEASE_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK55747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="135" mass="15752" checksum="06BBFC1617FF15CD" modified="2010-10-05" version="1">MNNNTFTKEERLCSKRLIDSLFLSGSSFVLYPFRIVFCQAADIAVPAQVIISVSKRRYKKAVTRNLLKRRMREAYRTQKKEILYSFLEDHHLNLLIAIQYVGKTELSFAEMKVKLALALNKLKNESNHLYLGKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTY2</accession>
    <name>D7VTY2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="7">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">murE</name>
        <name evidence="12" type="ORF">HMPREF0766_14452</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002299.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14452"/>
    <dbReference type="EnsemblBacteria" id="EFK55761">
        <property type="protein sequence ID" value="EFK55761"/>
        <property type="gene ID" value="HMPREF0766_14452"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022291_4_1_10"/>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="11">
        <location>
            <begin position="110"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="10">
        <location>
            <begin position="327"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="7">
        <location>
            <begin position="154"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Meso-diaminopimelate binding" evidence="7">
        <location>
            <begin position="403"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif" evidence="7">
        <location>
            <begin position="403"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="112"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK55761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="484" mass="53237" checksum="96904BD7FC095F45" modified="2010-10-05" version="1">MIKLKDILHAIPVQEVVGQLDVEVTSLCFDSRQANEGSLFVAVRGVHTDGHLFVEKAIQQGCTLIMVEEMPAEKSEGVTYMMVADTAYALGIAAGNFYGNPSRELKLVGVTGTNGKTTIATLLFNLFTALGYHVGLLSTVQNQIGERIIPATHTTPDPVALNALLRDMVDEGCDYCFMEVSSHAVVQQRIAGLRFAGGIFSNITHDHLDFHKTFDNYIKAKKKFFDDLDRFAFALTNGDEKNGSVMLQNTFAHKKTYGLKGVADFKAKIIESHFDGMLLNIEGHEVWVKLVGEFNAYNILAVYGAAILLEQETVKVLTALSQITGAEGRFEAITSKNGVIGIVDYAHTPDAVANVLSTINNLRKKEQQIITVLGCGGDRDKTKRPEMAEVAAKMSDKVIITSDNPRTEDPVQIIKDMEPGIPADRKKNVFSITDRKEAIRAACHLAQPGDIVLVAGKGHEKYQDINGVKHHFDDREELEKTFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTY4</accession>
    <name>D7VTY4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cell division protein FtsL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002301.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14454"/>
    <dbReference type="EnsemblBacteria" id="EFK55763">
        <property type="protein sequence ID" value="EFK55763"/>
        <property type="gene ID" value="HMPREF0766_14454"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50313N0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110694_1_0_10"/>
    <dbReference type="OrthoDB" id="1792543at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045755">
        <property type="entry name" value="FtsL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19579">
        <property type="entry name" value="FtsL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK55763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="136" mass="15959" checksum="4E08EEC993E3700A" modified="2010-10-05" version="1">MKRNTIKQKELSEEVQEELQDTVEEKAEETRHFIKSVFSPQKITTYSVVKNLPFIAFIALLALLYISNRHLAERTVRQIDRLSKEVKELSWDYKSLSAELMKRTTQSEIAKRADTLGLKERKEPPIKIEVVKEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VG82</accession>
    <name>D7VG82_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10001"/>
    <dbReference type="EnsemblBacteria" id="EFK60057">
        <property type="protein sequence ID" value="EFK60057"/>
        <property type="gene ID" value="HMPREF0766_10001"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1630675_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019861">
        <property type="entry name" value="PorP/SprF_Bacteroidetes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11751">
        <property type="entry name" value="PorP_SprF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK60057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="162" mass="18362" checksum="48C55D9B4BB2C71F" modified="2010-10-05" version="1" fragment="single">GDPAFQTVQYGTLLYGLSASLVRPDKYYVGVSMPRSIFGSKESDYVRQFGRDNTFYVSSGVIFDLDNQMYIRPSLLASYRPVTGVQFDGTVMLFFHEKFGIGAGYRQRGDLMGMAEFNLGRLRIGYSYQQNLKNSDLNRYIANSTHELGLSVRFGNQSRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VG94</accession>
    <name>D7VG94_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001842.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10013"/>
    <dbReference type="EnsemblBacteria" id="EFK60069">
        <property type="protein sequence ID" value="EFK60069"/>
        <property type="gene ID" value="HMPREF0766_10013"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1983">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182832_1_0_10"/>
    <dbReference type="OrthoDB" id="2022704at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="73" mass="8601" checksum="6588ADBC02F74C94" modified="2010-10-05" version="1">MIEKILYYFEQQSFGVCAYLGEKFSISIAKLRLFFIYATIIGAGFPILFYLFAGVLLDFRAYVKKMRKHLWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VG98</accession>
    <name>D7VG98_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001854.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10017"/>
    <dbReference type="EnsemblBacteria" id="EFK60073">
        <property type="protein sequence ID" value="EFK60073"/>
        <property type="gene ID" value="HMPREF0766_10017"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZF6T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1229033_0_0_10"/>
    <dbReference type="OrthoDB" id="1175559at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK60073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="222" mass="26166" checksum="8D68163C1C528A30" modified="2010-10-05" version="1">MNVKIARAVTQGLETYAANEGHDHQELLNRLHQAFDAQKPFLEKVDLLDAAFDDHMRFDELREICFDLLLMNFFSEDVQKLEEDYLDSPEWESIEDQTIDRGTELLNIFLYLRECADDEIEPELEDYLKEFLLVDEDEFQDEHRIYEKVIANQILVDSSYAEIAKVAETVDNQDELYEVFYPMMSFFSESNPSEKQLEEYKSAALNKSLDLALYQIIINYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGB4</accession>
    <name>D7VGB4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001904.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10033"/>
    <dbReference type="EnsemblBacteria" id="EFK60089">
        <property type="protein sequence ID" value="EFK60089"/>
        <property type="gene ID" value="HMPREF0766_10033"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50338XQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1524199_0_0_10"/>
    <dbReference type="OrthoDB" id="1778721at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK60089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="176" mass="20040" checksum="2AC26D0B6C3C995B" modified="2010-10-05" version="1">MIDAERILKEEQMYFAKEIICNIPCHIGYVKRFRWRWMATQLNTFVFIAEVNGTMTQLMMRSFSKACYDYAIHNNKGWPRGLQSGVGAIAILVGDEITQDGAAYCMADPNAHFSAFEVPVAYLKKYKQPVHFRGTQIWGAIYYPYFSEIIRRICGKLAASQPQESMPPPLPSADLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGD2</accession>
    <name>D7VGD2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001946.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10051"/>
    <dbReference type="EnsemblBacteria" id="EFK60107">
        <property type="protein sequence ID" value="EFK60107"/>
        <property type="gene ID" value="HMPREF0766_10051"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133295_0_0_10"/>
    <dbReference type="OrthoDB" id="1869196at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK60107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="171" mass="19828" checksum="E4DB5507AFBE461A" modified="2010-10-05" version="1">MAKAKRILIPTDFSIHSLQFLITVLEEEPAAQVEVVLAYGMRSGSFMTELFIFSKEEYLQKVQSEEFIKGCQMIENRFGEKVSGLYADVLTSDNPNYIRNYLKGNHIHEVILHEEHYSTCTHKHYLDLHRPMMKAAPFLSVLSDSSLSEKQHAEQNEIADLFFRSQYDVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGF8</accession>
    <name>D7VGF8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK60133">
        <property type="protein sequence ID" value="EFK60133"/>
        <property type="gene ID" value="HMPREF0766_10077"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3239802_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK60133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="43" mass="4875" checksum="CE6034BD845A6ACB" modified="2010-10-05" version="1">MNFFFPISANGWLIFPKEKGKKESTLIRGGGIDKASLYRKNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGI2</accession>
    <name>D7VGI2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl hydrolase family 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_10101</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002058.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10101"/>
    <dbReference type="EnsemblBacteria" id="EFK60157">
        <property type="protein sequence ID" value="EFK60157"/>
        <property type="gene ID" value="HMPREF0766_10101"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044973_3_0_10"/>
    <dbReference type="OrthoDB" id="1444566at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK60157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="285" mass="33350" checksum="05A2DAA482B0FAF0" modified="2010-10-05" version="1">MAKKAVKRGSPSKKEVKDDRKVYLIWSIVIPVIIVLLAVSWHYRSGIRYYIREVVSGKEQNGWKDAKYDIRNVELMSKHDDKIFGIDISQYQGDIDWVQVNTINDKFPVDFIFIRATMGESGVDSRFKTNWKRANSRAKIRGAYHYFRPNENSLKQARNFVKTVHLKAGDLPPVLDIEEMPVNQSMDSLRTGLKRWLGFVEAHYGIKPILYSGDKFFTDFLEKEFSDHVIWIANYNFWIDDLKDHWDFWQFSEKGSVRGIKGNVDLNIYNGDIEKLESLAIPFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGR0</accession>
    <name>D7VGR0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flotillin-like protein FloA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">floA</name>
        <name evidence="6" type="ORF">HMPREF0766_10179</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooligomerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane raft</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the flotillin-like FloA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996802.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10179"/>
    <dbReference type="EnsemblBacteria" id="EFK59262">
        <property type="protein sequence ID" value="EFK59262"/>
        <property type="gene ID" value="HMPREF0766_10179"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4864">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_836378_0_0_10"/>
    <dbReference type="OrthoDB" id="827327at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01562">
        <property type="entry name" value="FloA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022853">
        <property type="entry name" value="FloA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12127">
        <property type="entry name" value="YdfA_immunity"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK59262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="328" mass="35085" checksum="A3BC6EEE3B4060FB" modified="2010-10-05" version="1">MNPEISLVLFIIGGIVAFFLLLYLLPVNLWFTAQLSNVKISLLNLVLMRLRKVPPSLVTNAMITSTKAGLRITSNDIETHYLAGGNVNKVIKALISADKANIPLDFKLATAIDLAGRDVFDAVQLSVNPQVINTPPVAAVAKDGIQLIAKARVTVRANINQLVGGAGEETILARVGEGIVTTIGSSANHKEVLENPDRISKTVLSKGLDSGTAFEILSIDIADIDIGDNVGAKLQTDQAEADLKVANARAEERRAMAVATEQEMKAKAQEAKAKVIEAESQVPLAMAEAFRNGNLGIMDYYKMQNIQADSDMRSSIARPGSGDKGNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHH5</accession>
    <name>D7VHH5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">rpsE</name>
        <name evidence="11" type="ORF">HMPREF0766_10444</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997471.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10444"/>
    <dbReference type="EnsemblBacteria" id="EFK59527">
        <property type="protein sequence ID" value="EFK59527"/>
        <property type="gene ID" value="HMPREF0766_10444"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0098">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065898_2_2_10"/>
    <dbReference type="OrthoDB" id="1505038at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="10">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK59527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="172" mass="17992" checksum="51D232921DA2BF70" modified="2010-10-05" version="1">MALSNIKRVKSSEIELKDRLVSIQRVAKVTKGGRTFSFSAIVVVGDENGIVGYGLGKAKEVTEAITKGIDDAKKNLVKVPIIKGTVPHPQYGKYSGGSVLIKPAVHGTGVLAGGAMRAVLESAGITDVLAKSLGSSNPHNVVKATVDALANMRDAYTVAQHRGVDLNKVFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHN9</accession>
    <name>D7VHN9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SPFH/Band 7/PHB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_10508</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997586.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10508"/>
    <dbReference type="EnsemblBacteria" id="EFK59591">
        <property type="protein sequence ID" value="EFK59591"/>
        <property type="gene ID" value="HMPREF0766_10508"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026777_0_0_10"/>
    <dbReference type="OrthoDB" id="387521at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="PTHR13806"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="5">
        <location>
            <begin position="40"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="235"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="405"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK59591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="706" mass="79164" checksum="043240131C237BCC" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHS2</accession>
    <name>D7VHS2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10541"/>
    <dbReference type="EnsemblBacteria" id="EFK59624">
        <property type="protein sequence ID" value="EFK59624"/>
        <property type="gene ID" value="HMPREF0766_10541"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026821_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045509">
        <property type="entry name" value="HD_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19276">
        <property type="entry name" value="HD_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="54"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="417" mass="48106" checksum="E64FAE23FC26D93E" modified="2010-10-05" version="1">MQSTLNKRKIVNDPVYGFVTIPSGCVFDLIQHPYFQRLRYIKQVSMTHLVYPGALHTRFQHAIGAMHLMSLAIDTLRSKEVRISLEEEEAALVAILLHDIGHGPFSHSLEHTIIEGVSHEMLSSLLMDRMNDEFGCKLDLAITIFNNKYERKFFHQLVSSQLDTDRMDYLNRDSFFTGVSEGVISFDRIIKMLNVHNDELVVELKGIYSVEKFLIARRLMYWQVYLHKTVIGAEQMLIKALKRAKALSDQGADLFATPAFSHFLKNRITKDNFLLDESHLQWFTRLDDTDIMSAIKTWADHEDKILSMLCRKLMARDLFRTVMSKEPFSEKTVEAVNQAVIDYFGITEDELEYFVFMQEVENSAYSPLQGGIKIVDKQGELKDITEASDLSNLEALARKVRKFAISYPKEVGYPWIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHS6</accession>
    <name>D7VHS6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997685.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10545"/>
    <dbReference type="EnsemblBacteria" id="EFK59628">
        <property type="protein sequence ID" value="EFK59628"/>
        <property type="gene ID" value="HMPREF0766_10545"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033ZH2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1119608_0_0_10"/>
    <dbReference type="OrthoDB" id="2097885at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="248" mass="28071" checksum="87D861DF6C900FE9" modified="2010-10-05" version="1">MTDKELDKLFRDQLGNAESTPSPDIWDRIEQELPKEEVTSKKTSIYPLWKWTAAAAIVATGIFSTWYFQQGEQESEHLTEHHAIPSHDKERSKPDVESIPSDPIVTERKDNERFAFEQEKLSKKRDDIPGEVAERPQQMEVSTANEGVQLVALSQQMDTVPNNISLPDLTTSVTDVPPLKALIESPEVEETMMAIHEPEKQKTFGIGTILNSLIGKADRSDGKKLHFDTDEEGSLSIQYITKNRKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI64</accession>
    <name>D7VI64_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10683</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10683"/>
    <dbReference type="EnsemblBacteria" id="EFK59766">
        <property type="protein sequence ID" value="EFK59766"/>
        <property type="gene ID" value="HMPREF0766_10683"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018337_0_0_10"/>
    <dbReference type="OrthoDB" id="107139at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106926" evidence="3">
        <location>
            <begin position="29"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="848" mass="94435" checksum="8FF457E2247AE902" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIA1</accession>
    <name>D7VIA1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxymethylenebutenolidase</fullName>
            <ecNumber evidence="3">3.1.1.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.45" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998072.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10720"/>
    <dbReference type="EnsemblBacteria" id="EFK59803">
        <property type="protein sequence ID" value="EFK59803"/>
        <property type="gene ID" value="HMPREF0766_10720"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_3_1_10"/>
    <dbReference type="OrthoDB" id="1889569at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008806">
        <property type="term" value="F:carboxymethylenebutenolidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107520" evidence="1">
        <location>
            <begin position="22"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="DLH" evidence="2">
        <location>
            <begin position="34"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="246" mass="26468" checksum="E59ED116AC21C246" modified="2010-10-05" version="1">MKTIFLILLTMGMVQTGFAQLQEVDYSDGEQKLKGLLSGADQKNKPGVLILPAWMGIDEEAKTAAENLAKAGYTAFIADIYGQGNIPKTSAEAGKIAGQFKSDYALYQQRIKVALDELVKQGADPQRIAVIGYCFGGTGALEAARAQLPVKAVVSIHGGLGKGDRANGPVRTKVLVLHGAADASVPASDIVALQKELDEAAADWQMIYYAASKHTFTNPNSPDYNPLAAKRSWQHLMMFLEEVLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIG6</accession>
    <name>D7VIG6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Non-homologous end joining protein Ku</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ku</name>
        <name evidence="4" type="ORF">HMPREF0766_10785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer. Interacts with LigD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic Ku family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998199.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10785"/>
    <dbReference type="EnsemblBacteria" id="EFK59868">
        <property type="protein sequence ID" value="EFK59868"/>
        <property type="gene ID" value="HMPREF0766_10785"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1273">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048975_0_1_10"/>
    <dbReference type="OrthoDB" id="1724780at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00789">
        <property type="entry name" value="KU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01875">
        <property type="entry name" value="Prokaryotic_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="Ku70/Ku80_beta-barrel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009187">
        <property type="entry name" value="Prok_Ku"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41251">
        <property type="entry name" value="PTHR41251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006493">
        <property type="entry name" value="Prok_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SSF100939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02772">
        <property type="entry name" value="Ku_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="3">
        <location>
            <begin position="52"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="251" mass="28795" checksum="68BCA7DF39E51DF0" modified="2010-10-05" version="1">MRAIWTGAIGFGLVNIPVKIYSATQSSSLDLDMLDRKDKSNIKYKRVNEKTGKEVAWENIVKGYMLKDKYVVLEDADFEDASPEKNKMINLRSFVKLEEIDSIYFDTPYYLEPQKGGEKAYQLLLKGLEKSKTAGLGSFVMRNIENLVIIKPYQNMLLLNKLRFEEEIRSAEELKIPGASKIKKEEMDMALQLIKQHSHSFDISGYKNEYTRDLLKIIKQKEKGKRATIRKMTVENTKAADLLAQLKASLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIH4</accession>
    <name>D7VIH4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998214.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10793"/>
    <dbReference type="EnsemblBacteria" id="EFK59876">
        <property type="protein sequence ID" value="EFK59876"/>
        <property type="gene ID" value="HMPREF0766_10793"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046542_0_0_10"/>
    <dbReference type="OrthoDB" id="1540624at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025519">
        <property type="entry name" value="DUF4407"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14362">
        <property type="entry name" value="DUF4407"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="368" mass="41697" checksum="E0F50CA44E99CAB3" modified="2010-10-05" version="1">MNSVSRFFWYCAGVHQDTLIKYPEEHNKYVSIGATIFFTGLFAALSGGYALYFVFSGNPLSVVYAILFGLIWGLAIFNLDRYIVLSIDKTKGSGKQFLQAFPRILLAILVGVVISRPLELKIFDKEIREHLRGSYLSQQRAKIDTLNQTFENKYATEYGQLNGLKKQADSLDSNIKSDKQKLNFEIFGNKTTETSGVMGYGPYAKMKEAQLKKQEIYLDTLRTRIQQKESVLQDRKAFEGILDQKLLSNKSLDSAVNIAGFADRNAALGNLKFKADGTVDQATENAVLFIALLFIFFECLPVFVKLMSGRDSYDQALLSQREIHDYESHTSIAVEKSAIDNLEGFRTDVSIKKRMDKLNNDYHQEKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIH8</accession>
    <name>D7VIH8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">alkH</name>
        <name evidence="9" type="ORF">HMPREF0766_10797</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998220.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10797"/>
    <dbReference type="EnsemblBacteria" id="EFK59880">
        <property type="protein sequence ID" value="EFK59880"/>
        <property type="gene ID" value="HMPREF0766_10797"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_3_1_10"/>
    <dbReference type="OrthoDB" id="293754at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:cellular aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="PTHR43570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="19"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 6">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="473" mass="53661" checksum="C1241E422F9C9CC1" modified="2010-10-05" version="1">MAEAPRTPLAQISSLYCRQLDYKEKTRQLSVEQRISLLRSLGKQIENNHSAITKALHLDFRKNTFETDYTEIYVVQSTIKHICRNLKRWAQNRKVKNNLMYITTRSYLQYEPKGSSLIITPWNYPFQIPLMQTISSIAAGNTVMLKLSEYVPHTNVIVEEIIRSVFKQEHVTVINGQAEETTHLLNLKFDHIHFTGSPKVGKIVMQAASAHLSDITLELGGKSPVFIDKDVNLRQIVRNLIWGKFVNAGQTCIAPDYVLIDKNLKDTFEKILPEEVIMAFGTSAEQSPDLARIINDRQFDRLDTALKKAVQAGARILTGGETNKTSLYIAPTVVTDMPADSSLMTEEIFGPILPVVYYDTVDEALTLVSRKEKPLALYIFSNNRHYTDTVLRNTTAGSTAVNDMLIQYMHPNLPFGGVNHSGIGQSFGQYGFKSFSHERTVVSGSKNLPLSRIFWYPYTAKTRKLFNFIKRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIK0</accession>
    <name>D7VIK0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK59902">
        <property type="protein sequence ID" value="EFK59902"/>
        <property type="gene ID" value="HMPREF0766_10819"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3157942_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="48" mass="5675" checksum="0A92D1B3E3166448" modified="2010-10-05" version="1">MINSKSNDFGFCFDCFFLNLFFLEARIFAHFINGFKADFLDLNNLIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIL9</accession>
    <name>D7VIL9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998302.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10838"/>
    <dbReference type="EnsemblBacteria" id="EFK59921">
        <property type="protein sequence ID" value="EFK59921"/>
        <property type="gene ID" value="HMPREF0766_10838"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017617_1_0_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041700">
        <property type="entry name" value="OMP_b-brl_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14905">
        <property type="entry name" value="OMP_b-brl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMP_b-brl_3" evidence="1">
        <location>
            <begin position="381"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="806" mass="91342" checksum="939FE27F059AF7A4" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIP1</accession>
    <name>D7VIP1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CDP-alcohol phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998350.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10860"/>
    <dbReference type="EnsemblBacteria" id="EFK59943">
        <property type="protein sequence ID" value="EFK59943"/>
        <property type="gene ID" value="HMPREF0766_10860"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115797_0_0_10"/>
    <dbReference type="OrthoDB" id="1702107at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="193" mass="22447" checksum="001A57968E5D3EC9" modified="2010-10-05" version="1">MDTKKENIWNVPNALSIYRILALPFIIYAIYVGDKPLFITLLSINLITDILDGLIARVFRLQTEFGARLDSLADIGTYIMAFAGMIMLEKSFVMEHRIEFSLLIGMWLLPQLVSLIRFRRFPSFHLWSYKVTGYVQGIFIFTFFIFGVSTIYFYIMLVISLLAYMEELLLVSILPKLRSNVKSSLFVWNKSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIQ5</accession>
    <name>D7VIQ5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998379.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10874"/>
    <dbReference type="EnsemblBacteria" id="EFK59957">
        <property type="protein sequence ID" value="EFK59957"/>
        <property type="gene ID" value="HMPREF0766_10874"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50335VW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107940_0_0_10"/>
    <dbReference type="OrthoDB" id="1705889at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107538" evidence="2">
        <location>
            <begin position="24"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="214" mass="24351" checksum="0E325FC1CBAD230D" modified="2010-10-05" version="1">MRRRPLMLAIMLLLLAGCNSKTKKETQQVSEQADSGKTTSDQPDQKVEIQEIATRFVRAYLSQDSAKVNALIHPELGLTIILRIGAGDRFQQISTLDFANPLPGFYPYPTFQNDYGITFASLPTYSCEHEKWSKDGWFIDTTTHPNTLSSLAAFLDRVEEQEIPAEEIQKMKTLEQTSYRVILTGQESVIFHITRYQNAWYVTLLDRAYSSCDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIT8</accession>
    <name>D7VIT8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="14">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 20" type="primary">secA</name>
        <name evidence="20" type="ORF">HMPREF0766_10907</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="14">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the SecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="14"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998448.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10907"/>
    <dbReference type="EnsemblBacteria" id="EFK59990">
        <property type="protein sequence ID" value="EFK59990"/>
        <property type="gene ID" value="HMPREF0766_10907"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005314_0_0_10"/>
    <dbReference type="OrthoDB" id="212453at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-1278">Translocase</keyword>
    <keyword evidence="12 14 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14 15" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="19">
        <location>
            <begin position="2"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="177"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="603"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1041"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="193"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="693"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EFK59990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1099" mass="124287" checksum="AEC9DAC984516F99" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIV7</accession>
    <name>D7VIV7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gliding motility-associated lipoprotein GldH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gldH</name>
        <name evidence="2" type="ORF">HMPREF0766_10926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998490.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10926"/>
    <dbReference type="EnsemblBacteria" id="EFK60009">
        <property type="protein sequence ID" value="EFK60009"/>
        <property type="gene ID" value="HMPREF0766_10926"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50313I2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109250_0_0_10"/>
    <dbReference type="OrthoDB" id="1850223at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020018">
        <property type="entry name" value="Motility-assoc_lipoprot_GldH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14109">
        <property type="entry name" value="GldH_lipo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03511">
        <property type="entry name" value="GldH_lipo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107002" evidence="1">
        <location>
            <begin position="18"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="154" mass="17768" checksum="0796C635CE1D84C3" modified="2010-10-05" version="1">MKRLFYAFILLNVLVLAGCDPNTVVDENTIITDKSWPYNVIPKVKAHITDKNAKYDVYLNLRHNGDYRYANIFVRIHETNPKGVSKKERRELKLAELDGRWTGNSAGSLYAHQALIHENYSFPDTGVYTFAIEQNMRENPLKDINDVGIKIVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIW6</accession>
    <name>D7VIW6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">L-aspartate oxidase</fullName>
            <ecNumber evidence="4 10">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">nadB</name>
        <name evidence="13" type="ORF">HMPREF0766_10935</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the oxidation of L-aspartate to iminoaspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4 10"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998508.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10935"/>
    <dbReference type="EnsemblBacteria" id="EFK60018">
        <property type="protein sequence ID" value="EFK60018"/>
        <property type="gene ID" value="HMPREF0766_10935"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0029">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_3_0_10"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00551">
        <property type="entry name" value="nadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 10" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="11">
        <location>
            <begin position="7"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="12">
        <location>
            <begin position="441"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFK60018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="530" mass="59292" checksum="BDF8523E87D9148D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJD2</accession>
    <name>D7VJD2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">marR4</name>
        <name evidence="2" type="ORF">HMPREF0766_11101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000586.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11101"/>
    <dbReference type="EnsemblBacteria" id="EFK58985">
        <property type="protein sequence ID" value="EFK58985"/>
        <property type="gene ID" value="HMPREF0766_11101"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_18_6_10"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="33"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="170" mass="19471" checksum="254DC5CCAF55297A" modified="2010-10-05" version="1">MFLIAIVKLICFICINNLNQTKTMITNEAIYTEDFFNFLTGKATTALTRRLQQNLKESGINITAEQWSILYNLWQEEGLTQQELANRTFRDKPSVTRLINNLEKLNLVIRVNDRGDRRSNLIYLTKSGRQIKHKGLEQASKTISEALTGVSQEAIHSAHDTLSKVYVNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJR7</accession>
    <name>D7VJR7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">upp2</name>
        <name evidence="1" type="ORF">HMPREF0766_11236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000859.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11236"/>
    <dbReference type="EnsemblBacteria" id="EFK59120">
        <property type="protein sequence ID" value="EFK59120"/>
        <property type="gene ID" value="HMPREF0766_11236"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_2_0_10"/>
    <dbReference type="OrthoDB" id="1581906at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="214" mass="24089" checksum="EA1B7450E5838C29" modified="2010-10-05" version="1">MVTILTKQNSIANQYITELRDVKIQQDRMRFRRNLERIGEVMAYEISKTLEYRQHFVDTPLGVADTHVPSDYPVLGTIIRAGLPFHQGFLNVFDQADNAFIAAYRHTKKSGEFEIHKKYTNTPNLDDRVVIIADPMLATGRSLVLCCKDLLADYNIKELHIAVVIASEEGVQHVRAFLPEAQLWIGAVDNELTSKAYIVPGLGDAGDLAYGNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJS4</accession>
    <name>D7VJS4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000879.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11243"/>
    <dbReference type="EnsemblBacteria" id="EFK59127">
        <property type="protein sequence ID" value="EFK59127"/>
        <property type="gene ID" value="HMPREF0766_11243"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032896_3_1_10"/>
    <dbReference type="OrthoDB" id="663130at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010869">
        <property type="entry name" value="DUF1501"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07394">
        <property type="entry name" value="DUF1501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="421" mass="46230" checksum="58BE9C1A7DD00CCA" modified="2010-10-05" version="1">MLNRRAFLKNSGLGLFGIGLMGGIPAFLAEAVAREKLLSPYSKRKVMVCIFQRGAMDGLMAVTPFLDTHLQAARPDLFLSAAKSEGASALIDLDGKYGLHPGMKAFEEVFRENRLAIVHGMGSPNTTRSHFDAQDYMESGTPFEKNTSSGWLNRAVGLLGHDSLTPFSAVSITAALPRSLYGQHEALAISDIKNFKIQGKGVTFNQNARSFEDLYDNTVNEVLRDTGKESFEAMKMLQSNAVKNYEPANNVTYPGSSLGKSLKQIAQLIKMDVGLEVAFTESNGWDTHFNQGKDTGIFARNVADLSNSIMAFWKDIEAYQDDVTVMTMTEFGRTVYQNGTGGTDHGRGSCNFILGNQVNGGKVHGHMDELAKENLEDGRDLKVTTDFRAIFSEVADRHLKLNDDKILFPDWDGKSIGVMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK12</accession>
    <name>D7VK12_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11331</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998825.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11331"/>
    <dbReference type="EnsemblBacteria" id="EFK58614">
        <property type="protein sequence ID" value="EFK58614"/>
        <property type="gene ID" value="HMPREF0766_11331"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_0_1_10"/>
    <dbReference type="OrthoDB" id="448804at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="98"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="302"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="604" mass="68342" checksum="CE3F7C5DF7801A2F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK95</accession>
    <name>D7VK95_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-54 interaction domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ntrX</name>
        <name evidence="8" type="ORF">HMPREF0766_11414</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999050.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11414"/>
    <dbReference type="EnsemblBacteria" id="EFK58697">
        <property type="protein sequence ID" value="EFK58697"/>
        <property type="gene ID" value="HMPREF0766_11414"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_10"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="141"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="467" mass="52226" checksum="5E2509ED238A9216" modified="2010-10-05" version="1">MTTILIIDDERAIRSTLREILEYEDYKVFDADNALDGLEILKKEKIDLVLCDIKMEKMDGLEALTFAQTLKPEVPFIMISGHGTVETAVEATKKGAYDFLSKPLDLNRILITVRNALERGSLVEETKVLKKKVSSSKTKEILGSSDTISKIKETIERVAPTEARVLITGENGSGKELVARWLHEKSNRSSLPLIEVNCAAIPSELIESELFGHEKGSFTSAVKQRIGKFEQASGGTLFLDEIGDMSLSAQAKVLRALQEHKITRVGGEKEIDVNVRVIAATNKDLLKEIDAGNFRMDLYHRLSVILIHVPPLSQRTDDIPTIANSFCEEICGDYNMPVKKITMEAMKALQSLPWTGNIRELRNMVERLIILSDKSITDADVLTYANPSIVNPANGSSAGNETGKAVDYKGIFERFESFQDFKDHAEKEFINFKLDKNSWNVSKTADDIGIQRSHLYSKIEKFGLKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKD9</accession>
    <name>D7VKD9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999160.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11458"/>
    <dbReference type="EnsemblBacteria" id="EFK58741">
        <property type="protein sequence ID" value="EFK58741"/>
        <property type="gene ID" value="HMPREF0766_11458"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50333QF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1833941_0_0_10"/>
    <dbReference type="OrthoDB" id="1859556at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106980" evidence="1">
        <location>
            <begin position="22"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="140" mass="16211" checksum="C84E59052DB14C87" modified="2010-10-05" version="1">MKKIFLLFLSYLYLMSAFGVAIQTHLCKKETVQETSFFTRSIPPEEPCAICVSKNKGQTRKKDGCCQHETKVLKLTDEQQKVVKTDLSFKFWNEAILHRFFGAVFESPSVHLISAFDHYPQPLLSVQATPLYIYHCVYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKH2</accession>
    <name>D7VKH2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11491"/>
    <dbReference type="EnsemblBacteria" id="EFK58774">
        <property type="protein sequence ID" value="EFK58774"/>
        <property type="gene ID" value="HMPREF0766_11491"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032JM0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1081445_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032299">
        <property type="entry name" value="DUF4843"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16132">
        <property type="entry name" value="DUF4843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107614" evidence="1">
        <location>
            <begin position="24"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="257" mass="29869" checksum="F51E177E06518384" modified="2010-10-05" version="1">MKNYTYFLIVACFVMATIASCQKDQYYYFNDVARIQFGPPQYTGKTIYSEYADTSKSATFYYDENHIELDTVYFDIYTIGGIKNTDRVYKIQQMQLAGLENAVPGKHYVAFDDPSVQRLYVIKADSVHAQVPVILKRDPELKSKTLNLGIVVQENDNFKFGEQTKLWRKLSFTDRLSKPDAWTASYSQYYLGPYSVVKHAFMIEVTNERWDQPFMSNIPLDVINYYKSFLATALINYNKEHPNNPLKDENGVIIFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKJ5</accession>
    <name>D7VKJ5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_11514</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999327.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11514"/>
    <dbReference type="EnsemblBacteria" id="EFK58797">
        <property type="protein sequence ID" value="EFK58797"/>
        <property type="gene ID" value="HMPREF0766_11514"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_1_10"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="140"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="209" mass="22837" checksum="DFBD25CBBC2C8C13" modified="2010-10-05" version="1">MIEIMITDDHPMVLEGLKNVLATEEDLNLAACFTDGASLVAGLKEKQPDILLLDINLPDINSIELVARLKSAHPDMKIIALSVHNEFAVINSMLTEGASGYIQKNASGAEIITGIQTVYAGGRFLCAQSKLIMDKKTAEGLRNVPKITRREKEILQEAAKGLTSTEIADVLFISSHTVESHRKNLIEKFKVKNIASVIGLALEYGLIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKJ8</accession>
    <name>D7VKJ8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999334.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11517"/>
    <dbReference type="EnsemblBacteria" id="EFK58800">
        <property type="protein sequence ID" value="EFK58800"/>
        <property type="gene ID" value="HMPREF0766_11517"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZYDX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1576809_0_0_10"/>
    <dbReference type="OrthoDB" id="1678717at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="176" mass="21265" checksum="E5B39B60ABBF608D" modified="2010-10-05" version="1">MELRKEIEPRLDIAEKLYPEVLKLILDYTDYCDEHGDGELVEYKRLEQHLHLLTGKEMSSFNLWEWWEESRAEALAFDISLPDPEKTDHITMEELSEIVRRLKTYEEYEDSTNSFRSTFHLHLTFGNGYFDKFLKLNFKSYDPRLFQRNKDKNGNYFEYGIKEITDKLWNKGDYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKL2</accession>
    <name>D7VKL2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK58814">
        <property type="protein sequence ID" value="EFK58814"/>
        <property type="gene ID" value="HMPREF0766_11531"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3296712_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="40" mass="4605" checksum="AB996B6B515D1382" modified="2010-10-05" version="1">MLNYLIRNNYAYETTKIHSSKNSDPDPIILSELSDNALYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKM1</accession>
    <name>D7VKM1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999379.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11540"/>
    <dbReference type="EnsemblBacteria" id="EFK58823">
        <property type="protein sequence ID" value="EFK58823"/>
        <property type="gene ID" value="HMPREF0766_11540"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50335PU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166187_0_0_10"/>
    <dbReference type="OrthoDB" id="1999962at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="120" mass="13993" checksum="03B5359843AE7368" modified="2010-10-05" version="1">MKIIHKSDLLPLISAEIPEVSEEVNRLSSRENIAGAIQIVVTFMKDMLQHHNLPRVRWSMMFMGWLYGRSDAAVKEIIENLFVRSFNGMKRICNPQEWQSVETKIPYSLRSVYIRQLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKS6</accession>
    <name>D7VKS6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Signal peptide peptidase SppA, 67K type</fullName>
            <ecNumber evidence="6">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sppA</name>
        <name evidence="6" type="ORF">HMPREF0766_11595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999475.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11595"/>
    <dbReference type="EnsemblBacteria" id="EFK58878">
        <property type="protein sequence ID" value="EFK58878"/>
        <property type="gene ID" value="HMPREF0766_11595"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0616">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008856_1_1_10"/>
    <dbReference type="OrthoDB" id="1318587at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004634">
        <property type="entry name" value="Pept_S49_pIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004635">
        <property type="entry name" value="Pept_S49_SppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001217">
        <property type="entry name" value="Protease_4_SppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00705">
        <property type="entry name" value="SppA_67K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00706">
        <property type="entry name" value="SppA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="5">
        <location>
            <begin position="127"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="5">
        <location>
            <begin position="373"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="589" mass="64451" checksum="4805BE38194FA9C7" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKT8</accession>
    <name>D7VKT8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gpo2</name>
        <name evidence="6" type="ORF">HMPREF0766_11607</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999497.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11607"/>
    <dbReference type="EnsemblBacteria" id="EFK58890">
        <property type="protein sequence ID" value="EFK58890"/>
        <property type="gene ID" value="HMPREF0766_11607"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029507_1_1_10"/>
    <dbReference type="OrthoDB" id="1635499at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="PTHR11592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="170" mass="19367" checksum="86DA06CF6213C86B" modified="2010-10-05" version="1">MILMTLMVCMSMITNTPTVYDYSFKDMEGKTINLSDYKGKKILIVNTASKCGFTKQYKDLQALSEQYGDKVVVIGFPANNFGGQEPGSNEEIQDFCEKNFGVTFTLSEKVEVKGDQIDPLFKFLTNQENPDFKGEIKWNFEKFLIDENGKLIHRYRSAVNPLDKSITSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKZ0</accession>
    <name>D7VKZ0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">O-succinylhomoserine sulfhydrylase</fullName>
            <shortName evidence="2">OSH sulfhydrylase</shortName>
            <shortName evidence="2">OSHS sulfhydrylase</shortName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mdeA</name>
        <name evidence="2" type="synonym">metZ</name>
        <name evidence="5" type="ORF">HMPREF0766_11659</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the formation of L-homocysteine from O-succinyl-L-homoserine (OSHS) and hydrogen sulfide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>hydrogen sulfide + O-succinyl-L-homoserine = L-homocysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:27826"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from O-succinyl-L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the trans-sulfuration enzymes family. MetZ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999645.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11659"/>
    <dbReference type="EnsemblBacteria" id="EFK58263">
        <property type="protein sequence ID" value="EFK58263"/>
        <property type="gene ID" value="HMPREF0766_11659"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0626">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_0_10"/>
    <dbReference type="OrthoDB" id="637281at2"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071268">
        <property type="term" value="P:homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02056">
        <property type="entry name" value="MetZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006234">
        <property type="entry name" value="O-succ-hSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="2 3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2 3">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="390" mass="43326" checksum="68EFE0C65146AB9D" modified="2010-10-05" version="1">MNKDQSKIIREQADRSAQREHSVPLYLTSSFIFDSAEQGRAIFAEEEQGMVYSRYANPNTTELINKVCIMEQAEAGLAFSSGMAAVFASFAGIIESGDHIVSSRAIFGSTHQLFTQLFPKWGVTTTYVDAAHPEEWEKAIQPNTKIIFLESPSNPGLELVDLEWLGKFKEKYPNIILSIDNCFATPYLQKPILYGFDLVIHSATKYMDGQGRVLGGIVVGKQELIDKLMFFIRHTGPALSPFNAWVISKSLDTLGLRMDRHSSNALALAEALEHHAEIEDVKYPFLPSHPQYELAKKQMKAGGGIVTFVVKGGFERAKAFVDQLEMILYTSNLGDSRSIATHPASTTHSKLTEEERLNLGIRPGSIRLSVGLEDKEDIIGDILQALDKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL71</accession>
    <name>D7VL71_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gliding motility-associated protein GldL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gldL</name>
        <name evidence="2" type="ORF">HMPREF0766_11740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999827.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11740"/>
    <dbReference type="EnsemblBacteria" id="EFK58344">
        <property type="protein sequence ID" value="EFK58344"/>
        <property type="gene ID" value="HMPREF0766_11740"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8HM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082721_0_0_10"/>
    <dbReference type="OrthoDB" id="1802310at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019852">
        <property type="entry name" value="Motility-assoc_prot_GldL"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03513">
        <property type="entry name" value="GldL_gliding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="214" mass="22895" checksum="F6890B1EFBDF2AB7" modified="2010-10-05" version="1">MATKRKFKFGINTLINWGATVVIIGLMFKILHFKGGEWMIGIGLAVEALLFFIMGFLASESEVDWTRVYPELDEDYNGELPKAGARPAIAAAPAATGNTAALDKLLQDAKIDENLIGNLGDGLRTFSDKVASISKVADTATATNLFADKLNAASAGAANLSSAFDRAAADLKTFNESSTDMQQFKEQVSTFNKNLASLNAIYGNMLSAMNPNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL75</accession>
    <name>D7VL75_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-3-methyladenine glycosylase I</fullName>
            <ecNumber evidence="1">3.2.2.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tag</name>
        <name evidence="1" type="ORF">HMPREF0766_11744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.20" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999841.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11744"/>
    <dbReference type="EnsemblBacteria" id="EFK58348">
        <property type="protein sequence ID" value="EFK58348"/>
        <property type="gene ID" value="HMPREF0766_11744"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2818">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083758_1_0_10"/>
    <dbReference type="OrthoDB" id="1835478at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005019">
        <property type="entry name" value="Adenine_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004597">
        <property type="entry name" value="Tag"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03352">
        <property type="entry name" value="Adenine_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00624">
        <property type="entry name" value="tag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="189" mass="22067" checksum="52AFCDDAF7315A76" modified="2010-10-05" version="1">MPKSIVRCSWCGTDELYSQYHDKEWGKQVKDEKTLFEFLVLESAQAGLSWITILRKRENYRRLFANFEYKKVAEFTEKNVEELMQDAGIIRNRLKIKSTIENAKIFMKVQQEFGSFYNYLYSFMPDNAPIINEVKSMSDVPVSTPESDAIAKDLKKRGVKFFGTTICYAYMQAVGMVNDHIVTCSFRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLL1</accession>
    <name>D7VLL1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit D</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">nuoD</name>
        <name evidence="8" type="ORF">HMPREF0766_11881</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000205.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11881"/>
    <dbReference type="EnsemblBacteria" id="EFK58484">
        <property type="protein sequence ID" value="EFK58484"/>
        <property type="gene ID" value="HMPREF0766_11881"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_1_2_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="7">
        <location>
            <begin position="138"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="411" mass="47042" checksum="231D9D5CF8FB3593" modified="2010-10-05" version="1">MSDFITKITPNSPVYSDNDPQDELITLNIGPTHPATHGVFQNVVQIDGERIVSGVSTIGYIHRAFEKIAEHRPFYQITPLTDRLNYCSSPINNMGWHMTVEKLLNIEIPKRVQYMRVIVMELARIADHIICNGILGVDTGAFSGFLYVMQEREFIYEIFEEICGARLTTNIGRIGGFERDFNDVAFLKIREFLERFPPVLTEFEEMFVRNRIFIERTSGVAAVTPEQALSYSWSGPILRATGIDYDVRAQEPYCSYEEFDFEVPVGTTGDVYDRFMVRNAEMRQSMRIIEQALEKIAREPADVFHADVPEFYLPPKEQVYTNMEALIYHFKIVMGEWETPKAEVYHAVEGANGELGFYLIHDGGRTPYRLHFRRPSFVNYQMFAPMSSGMLISDAIINMSSLNVIAGELDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLT1</accession>
    <name>D7VLT1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12185"/>
    <dbReference type="EnsemblBacteria" id="EFK58193">
        <property type="protein sequence ID" value="EFK58193"/>
        <property type="gene ID" value="HMPREF0766_12185"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2071635_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="118" mass="13973" checksum="E121AF909FF83EFF" modified="2010-10-05" version="1">MRYIIFLLLFGISVHSYAQKLKIFVTKEKSHLDYDGYLLRLKVIKDGKSYETKPGDYESWFYFLRNFDLKDRVRILKKLSKYFDDYSLCSKAVKAVFPRVGIPMTADRILTEKNTALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLW3</accession>
    <name>D7VLW3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK57968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11960"/>
    <dbReference type="EnsemblBacteria" id="EFK57968">
        <property type="protein sequence ID" value="EFK57968"/>
        <property type="gene ID" value="HMPREF0766_11960"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055103_0_0_10"/>
    <dbReference type="OrthoDB" id="1571860at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="317" mass="37601" checksum="73D93D228C797125" modified="2010-10-05" version="1">MKSDMLYNWIPYSLKWEENEWKVLWLDLADHIIQESFFDETIVDRRIYMRSRSKYQSQSSVEYILELADQLESIAPTAFIFHVSRCGSTLLSQCLATDASNIMIPEAPVLDEILRIEEFDETLLPLREQLFKATVKLMGQQRLAFQTKYFIKMDSWHIHFYDVLRSWYPDVPFYFLTREPNAIIASQKKRRGIHCIPGYINEKLLKVPVRPGHFENFDSFTADVLHQFYDGIREIKSKRHRLNSYYDYSWGVSEMITDFNKAIGNILGDLEEMRARLTYHSKYPDQIFQVEVPLPDSIAFEHTHTAYQQVLKQITRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLY7</accession>
    <name>D7VLY7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK57992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001118.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11984"/>
    <dbReference type="EnsemblBacteria" id="EFK57992">
        <property type="protein sequence ID" value="EFK57992"/>
        <property type="gene ID" value="HMPREF0766_11984"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50316WB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134435_0_0_10"/>
    <dbReference type="OrthoDB" id="1846545at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="137" mass="15327" checksum="E569DA5ED795814C" modified="2010-10-05" version="1">MKKDLPENIVEDILISVVLEGDTPTSQNWKVYLINEKNEGLENVFVTSKGYGKKDGKEVKTTTLRHFIGDVAPASFVKIEAIDDQVFGLTNEYWLSYYIGGVIYDKKYIFLPESIVDENLSKVPLVNKPGVIIGGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMJ5</accession>
    <name>D7VMJ5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992622.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12215"/>
    <dbReference type="EnsemblBacteria" id="EFK57142">
        <property type="protein sequence ID" value="EFK57142"/>
        <property type="gene ID" value="HMPREF0766_12215"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3047">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117613_0_0_10"/>
    <dbReference type="OrthoDB" id="2018542at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107127" evidence="1">
        <location>
            <begin position="21"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="192" mass="20130" checksum="0F8AF32D9C21248D" modified="2010-10-05" version="1">MKKLFLPFILLLGTVGVTQAQKIETKPQTSADVGMRPIQTGNWMVGGSIGSLGYSFEGKSFNAALNPRAGYFVSDGIAIGAEGMLGLTTIKDGENDWRYGIAPFVRYYFPEGASSTGRFFGQGSVGIAGSSLGDGATFTAGANLGYAHFITQTVALEATFGYNYSKANVSGADKSTGLGFGVGFQIYLPGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMJ8</accession>
    <name>D7VMJ8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Shikimate kinase</fullName>
            <shortName evidence="2">SK</shortName>
            <ecNumber evidence="2">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">aroK</name>
        <name evidence="3" type="ORF">HMPREF0766_12218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992629.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12218"/>
    <dbReference type="EnsemblBacteria" id="EFK57145">
        <property type="protein sequence ID" value="EFK57145"/>
        <property type="gene ID" value="HMPREF0766_12218"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057607_4_0_10"/>
    <dbReference type="OrthoDB" id="1392851at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="177" mass="20436" checksum="DB0CB086714823FE" modified="2010-10-05" version="1">MNLPVFLIGYMGSGKTTIGKKLANKMNVPFIDLDEEIVKHIGMPIAQYFETHSEEAFRNLEREFLQKQEGVSGIISTGGGTPCFHDNMNWINERGISLYLKMTPKSLWDRLSKSDVKKRPILLGLKGEELYQFIESKLQEREPFYNQAHIIFEKLDRDLDEIIQLIHTHNKENSPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMN2</accession>
    <name>D7VMN2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992702.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12252"/>
    <dbReference type="EnsemblBacteria" id="EFK57179">
        <property type="protein sequence ID" value="EFK57179"/>
        <property type="gene ID" value="HMPREF0766_12252"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059523_1_0_10"/>
    <dbReference type="OrthoDB" id="1194699at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="61"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="326" mass="37155" checksum="E1E07D240569A54A" modified="2010-10-05" version="1">MNKSRRKFLKQAGVGVSAAFLSPYLLSCESKKIAEGPFQHIGIQLYTLRDELAKDAKGTIEKIAKIGYKHVETFGVDVAKGEFFGLPIKDFKKLLDDNNLETHSGHYDLSKYLSKNHEDKESVERYVEIAKELGQSYVVAPVTPMFDINALKSADYQYAAEQLNKAGEISKKSGIKMGYHNHFWEFRDQPNGTKGLDILIAFTEPELVDFELDLYWIEKSGLSPQSYFEKYPNRFSMWHVKDMDKAFTKPIVGGEQDKLGFGDIIKEIKYAEVGTGNIDFTNIVKYADKSGLKYAFVEQDDIYMADKFASIKKSYDYVENTLTKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMP9</accession>
    <name>D7VMP9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Uronate isomerase</fullName>
            <ecNumber evidence="4 6">5.3.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glucuronate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Uronic isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">uxaC</name>
        <name evidence="7" type="ORF">HMPREF0766_12269</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>D-glucuronate = D-fructuronate</text>
            <dbReference type="Rhea" id="RHEA:13049"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:59863"/>
            <dbReference type="EC" id="5.3.1.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>aldehydo-D-galacturonate = keto-D-tagaturonate</text>
            <dbReference type="Rhea" id="RHEA:27702"/>
            <dbReference type="ChEBI" id="CHEBI:12952"/>
            <dbReference type="ChEBI" id="CHEBI:17886"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate metabolism; pentose and glucuronate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.12" evidence="4 6"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992726.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12269"/>
    <dbReference type="EnsemblBacteria" id="EFK57196">
        <property type="protein sequence ID" value="EFK57196"/>
        <property type="gene ID" value="HMPREF0766_12269"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1904">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044465_1_0_10"/>
    <dbReference type="OrthoDB" id="167900at2"/>
    <dbReference type="UniPathway" id="UPA00246"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008880">
        <property type="term" value="F:glucuronate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006064">
        <property type="term" value="P:glucuronate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00675">
        <property type="entry name" value="UxaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003766">
        <property type="entry name" value="Uronate_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02614">
        <property type="entry name" value="UxaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="466" mass="53730" checksum="003E4861A5ED490B" modified="2010-10-05" version="1">MKSFLDQNFLLHSKTAQDLYHNFAKNQPIIDYHNHLIPEQIANNASFENISQVWLNGDHYKWRAMRTNGVNEKYITGNASDEEKFRKWAETVPSTMRNPLYHWTHLELQRYFGITDLLSAKTADKIYADTAARLQTPEYSVRGLLKKMNVEVVCTTDDPTDSLNYHQQFAAEKESFKMLPAFRPDKAMNSDDIEALNAYINKLESVSDRSISTLQEYLDALKKRHDFFADNGCSVSDHGLEQIYAEDYTEQEIADIFAKIRARQTISYQENLKFKSAMLIYFAEWDHEKGWVQQYHLGALRNNNSRMLSILGPDTGWDSIGDFSQARALSKFLNKLDTQDKLAKTIIYNLNPADNELIATMIGNFNDGSVAGKIQFGSAWWFLDQKDGMTKQMNALSNMGLLSRLVGMLTDSRSFLSFPRHEYFRRLLCDLFGQDVENGELPNDIEEIGKIIADISYFNAKNYFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMR5</accession>
    <name>D7VMR5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Biotin carboxylase</fullName>
            <ecNumber evidence="5">6.3.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetyl-coenzyme A carboxylase biotin carboxylase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">accC</name>
        <name evidence="8" type="ORF">HMPREF0766_12285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992756.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12285"/>
    <dbReference type="EnsemblBacteria" id="EFK57212">
        <property type="protein sequence ID" value="EFK57212"/>
        <property type="gene ID" value="HMPREF0766_12285"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0439">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_3_2_10"/>
    <dbReference type="OrthoDB" id="361205at2"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004549">
        <property type="entry name" value="Acetyl_CoA_COase_biotin_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00514">
        <property type="entry name" value="accC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1 5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="7">
        <location>
            <begin position="1"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="120"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK57212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="454" mass="50378" checksum="56CC9562ABFD539A" modified="2010-10-05" version="1">MFKKILIANRGEIALRIIRTCREMGIKSVAVYSTADRDSLHVRFADEAVCIGPPPSKDSYLNIPNIISAAELTNADAIHPGYGFLSENARFSAICAEYGIKFIGATAEQIEKMGDKSSAKATMKEAGVPTVPGSEGLLSNVKEGIQLANEIGYPVIIKATAGGGGRGMRIIWKDEDFEAAWDSARQESAAAFGNDGIYLEKYVEEPRHIEIQVVGDQYGTVCHLSERDCSIQRRHQKLLEEAPSPFITPELRQTMGEAAIKGAKAVNYEGAGTIEFLVDKHRNFYFMEMNTRIQVEHPVTEEVINFDLIKEQIKVAAGIPISGKNYEPTMHAIECRINAEDPFQNFRPSPGKITNFHSPGGHGVRVDTHVYSGYTIPPNYDSMIAKLITVAQTREEAISTMERALSEFVIEGIHTTIPLHLRILKDPNFRAGNFTTKFMETFDLSKYPEEEENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMR9</accession>
    <name>D7VMR9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpmF</name>
        <name evidence="6" type="ORF">HMPREF0766_12289</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12289"/>
    <dbReference type="EnsemblBacteria" id="EFK57216">
        <property type="protein sequence ID" value="EFK57216"/>
        <property type="gene ID" value="HMPREF0766_12289"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129084_2_3_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044957">
        <property type="entry name" value="Ribosomal_L32p_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35534">
        <property type="entry name" value="PTHR35534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK57216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="63" mass="7236" checksum="52EBA3BBED9C22ED" modified="2010-10-05" version="1">MAHPKRKTSKSRRDKRRTHYKAEKPSLTVCQETGAVHLPHRAYTVDGNLYYNGKLIIENTAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMS4</accession>
    <name>D7VMS4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992769.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12294"/>
    <dbReference type="EnsemblBacteria" id="EFK57221">
        <property type="protein sequence ID" value="EFK57221"/>
        <property type="gene ID" value="HMPREF0766_12294"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083598_0_0_10"/>
    <dbReference type="OrthoDB" id="1948290at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="174" mass="20434" checksum="28EDDC37088F4D1A" modified="2010-10-05" version="1">MVSLRYRCSGFIHALTSNTRHGTHSPFVYKLADEAIYQRSAKGVEINLSGWSSKKKAALVRILYHLGIQTVHSLSDNRGNEAEQDVVETPEDCFKQAILISKDELPEQQEFHRAGRHTIYIWDEPYFNRERQSAWQQVQQAERVTLTIDLFYFGLIIFRQGQRKQNFKLRFPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMZ4</accession>
    <name>D7VMZ4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="7">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="7">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fabH</name>
        <name evidence="10" type="synonym">fabHA</name>
        <name evidence="10" type="ORF">HMPREF0766_12364</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992882.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12364"/>
    <dbReference type="EnsemblBacteria" id="EFK57291">
        <property type="protein sequence ID" value="EFK57291"/>
        <property type="gene ID" value="HMPREF0766_12364"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039592_4_1_10"/>
    <dbReference type="OrthoDB" id="872193at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="9">
        <location>
            <begin position="108"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="8">
        <location>
            <begin position="259"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="7">
        <location>
            <begin position="276"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK57291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="348" mass="38328" checksum="51FF90AE4811D204" modified="2010-10-05" version="1">MFQSKIAGIGYYVPKNVYTNNDLTRFMDTSDEWIQERTGIKERRYADRLGETTTTMAIEASKIAIERANTTAEEIDFVIFATLSPDYYFPGCGVLLQREMGMKEIGALDIRNQCSGFIYAISVADQFIKTGMYKNILVVGSEKQSFAMDFATRSRSVSVIFGDGAGAVVLQPTQDAGKGILSTHLHSDGADAEKLAMYYPGASAGKWLDNPPQWPDQELGGLYMTKEMLEDGSTSAYMDGQAVFKKAVVKFPEVIGEALAKNNLVSTDIDMLIPHQANLRISQYVQKTLGLRDDQVFNNIQKYGNTTAASVPIALCEAWEEGKIKEGDLVCLAAFGAGFTWGSALIRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNB9</accession>
    <name>D7VNB9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993046.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12489"/>
    <dbReference type="EnsemblBacteria" id="EFK57416">
        <property type="protein sequence ID" value="EFK57416"/>
        <property type="gene ID" value="HMPREF0766_12489"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_106_3_10"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="588" mass="68082" checksum="C94859A38E65DE05" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNC0</accession>
    <name>D7VNC0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993047.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12490"/>
    <dbReference type="EnsemblBacteria" id="EFK57417">
        <property type="protein sequence ID" value="EFK57417"/>
        <property type="gene ID" value="HMPREF0766_12490"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1254110_0_0_10"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="221" mass="25578" checksum="CB60C844B4FE8F38" modified="2010-10-05" version="1">MFRKVLIAEDQESANISVRKTLADLGIQHTDYVYYCDDALTRIEKALKADQPYDLLITDLSFEEDQYRQRLPNGDDLIRAVKQEQPTIKIVVFSAEDKSQVIDTLFEDLSIDAYVRKARNDAQYLKEAINTICQNRKYRSPNLKPIVKERNSYEFADFDITIISLLSQGVLQKDIPFHLQQRNIKPSGLSSVEKRLNHMKESLDFTKNEQLIAFCKDIGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNF7</accession>
    <name>D7VNF7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993095.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12527"/>
    <dbReference type="EnsemblBacteria" id="EFK57454">
        <property type="protein sequence ID" value="EFK57454"/>
        <property type="gene ID" value="HMPREF0766_12527"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009520_1_0_10"/>
    <dbReference type="OrthoDB" id="1444566at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107731" evidence="1">
        <location>
            <begin position="21"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="371"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="444"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="490" mass="54637" checksum="950753B1551B8029" modified="2010-10-05" version="1">MVKMKVTTLSLFGFLCIAQANVQGQSSSSFKDDLQTTLLQNLADENTQILKELDSIKFVNAGEKNVDNVVFDIQDVGMVRKLLSLQREVPLNYNAQVRNYIELYSSKNYKPHMSKMLGLGQYYFPIYEKIFKEMNVPDEIKYLSIVESALNPHSVSRVGATGPWQFMYGTAKSYNLIMDNYLDERKDPYASCYAAARYMQDSYQEFGDWLVAIASYNCGKGNIKRAIAKSGKTNPNFWEISAYLPRETRNYVPAFIAMTYMMGYAAENNIEAATTDYHLATDMMMVDKSLNLNSIAQALNLSEEALKMLNPGYKKGIVNGTAETPRRLVIPKLAGMDEEKLYTALNSPVETMAAVVEAVNDDLRVSPNAMTRHRVRKGETLQSISRKFGVSVQNLKAWNDISSSRAPVGRTLIVSSPGVNERLASRVSKSKAATTSKKSTSTYLSYTVKRGDTLSDIANKYKGATVSNIKADNGLSSSKLKPGMKLKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNF9</accession>
    <name>D7VNF9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NlpC/P60 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nlpC</name>
        <name evidence="4" type="ORF">HMPREF0766_12529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993097.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12529"/>
    <dbReference type="MEROPS" id="C40.004"/>
    <dbReference type="EnsemblBacteria" id="EFK57456">
        <property type="protein sequence ID" value="EFK57456"/>
        <property type="gene ID" value="HMPREF0766_12529"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016043_9_0_10"/>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107465" evidence="2">
        <location>
            <begin position="22"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="53"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="199" mass="22295" checksum="58F264F05B9BB87C" modified="2010-10-05" version="1">MKTKKIVALVLFIGLCLVSQAQSTKTQSKSESADPDNLAKDYFSQIMGVAVSATTNTKLYQFVYDWIGTPYRLGGDSKRGIDCSKFAYELYDKVFNTSIGYNSRNIYTQVDPIGKSELKAGDLVFFKIRSKSITHIGVYLGDDKFAHASSSKGVMISNLNEAYWKRYYYNGGRMPIDNSEEIGRVLTADLLKERKATVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNP6</accession>
    <name>D7VNP6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heavy metal efflux pump, CzcA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">czcA</name>
        <name evidence="2" type="ORF">HMPREF0766_12616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993216.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12616"/>
    <dbReference type="EnsemblBacteria" id="EFK57543">
        <property type="protein sequence ID" value="EFK57543"/>
        <property type="gene ID" value="HMPREF0766_12616"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_10"/>
    <dbReference type="OrthoDB" id="91817at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="614"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1242"/>
            <end position="1262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1283" mass="142163" checksum="F3AB57F6D44319E2" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP88</accession>
    <name>D7VP88_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rpsG</name>
        <name evidence="8" type="ORF">HMPREF0766_12808</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993544.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12808"/>
    <dbReference type="EnsemblBacteria" id="EFK57735">
        <property type="protein sequence ID" value="EFK57735"/>
        <property type="gene ID" value="HMPREF0766_12808"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072226_1_1_10"/>
    <dbReference type="OrthoDB" id="1540940at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="7">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK57735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="155" mass="17803" checksum="D788FF61CBE291B1" modified="2010-10-05" version="1">MRKSKPKKRIILPDPKFNDVQVTRFVNNMMYDGKKSIAYDIFYKAVELVEQKTSESGLETWKKALNNVMPAVEVKSRRVGGANFQVPMEVRPERKIALGMKWLISYSRRRGEKTMFEKLAGEIISASKGEGAAVKKKEDTHKMAEANKAFSHFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPB7</accession>
    <name>D7VPB7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 3-deoxy-7-phosphoheptulonate synthase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pheB</name>
        <name evidence="3" type="ORF">HMPREF0766_12837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993601.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12837"/>
    <dbReference type="EnsemblBacteria" id="EFK57764">
        <property type="protein sequence ID" value="EFK57764"/>
        <property type="gene ID" value="HMPREF0766_12837"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062599_1_1_10"/>
    <dbReference type="OrthoDB" id="687380at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="2">
        <location>
            <begin position="269"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="368" mass="40950" checksum="5E584735E27608EA" modified="2010-10-05" version="1">MKHTLDILPLKSWLDTGDRPLIIGGPCSAETEEQLVSTAHLLANTGKVNVLRAGIWKPRTRPGEFEGIGSIGLEWLKRAKEETGLLTATEVATAKHVEEALAAGVDILWIGARSTANPFTVQEIADALQGVDVPVLVKNPVNPDLSLWVGALERINRAGIKKLAAIHRGFSSYEKTAFRNEPMWDLAIQLKTLIPDLPVINDPSHICGNRELIPYIAQKAMDMDMQGLIIESHIDPSVAWTDAKQQLTPAALAELVGHLSLRRPESDNPAFEDKLSELRAEIDKLDDRIIQQIGDRMKIAEKIGEYKRDNNVTILQVSRWDEIVQKRAKLANALNLDQDFTVKFLELLHNESIRRQNEVMNNTPATEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPC2</accession>
    <name>D7VPC2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphorylase family</fullName>
            <ecNumber evidence="2">2.4.2.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">udp</name>
        <name evidence="2" type="ORF">HMPREF0766_12842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.3" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993609.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12842"/>
    <dbReference type="EnsemblBacteria" id="EFK57769">
        <property type="protein sequence ID" value="EFK57769"/>
        <property type="gene ID" value="HMPREF0766_12842"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075954_0_0_10"/>
    <dbReference type="OrthoDB" id="1028277at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="29"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="284" mass="31337" checksum="7224349D0152E70A" modified="2010-10-05" version="1">MIPASELIINTDGSIYHLNIMPEDLANTVITVGDPDRVAEVSKYFDHIELKKGKREFITHTGTVRGKRISVISTGIGTDNIDIVLNELDALVNIDFQSREPKSDMISLDIIRVGTSGAVQADLPMGTILASEVGIGFDALMQYYKRTLSALETEIQQEIGQQFPDLHFQPYVAQASDKLLKQFASDLPKGMTATAPGFYGPQGRALRTQNVYPDFINKINRFRVGDRRITNLEMETAGIYAMAAALGHHALSINAILASRVSATFSPEPQKIVEKAIQYVLERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPD0</accession>
    <name>D7VPD0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase family M1</fullName>
            <ecNumber evidence="3">3.4.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pepN</name>
        <name evidence="3" type="ORF">HMPREF0766_12850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993619.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12850"/>
    <dbReference type="EnsemblBacteria" id="EFK57777">
        <property type="protein sequence ID" value="EFK57777"/>
        <property type="gene ID" value="HMPREF0766_12850"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014298_1_1_10"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="2">
        <location>
            <begin position="48"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="1">
        <location>
            <begin position="296"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="549" mass="63092" checksum="F21CFCE1238F9FBE" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPG2</accession>
    <name>D7VPG2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">poxB</name>
        <name evidence="6" type="ORF">HMPREF0766_12882</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993679.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12882"/>
    <dbReference type="EnsemblBacteria" id="EFK57809">
        <property type="protein sequence ID" value="EFK57809"/>
        <property type="gene ID" value="HMPREF0766_12882"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_3_0_10"/>
    <dbReference type="OrthoDB" id="351701at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="192"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="380"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK57809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="577" mass="63226" checksum="60F7ED2359532239" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPH9</accession>
    <name>D7VPH9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc metalloprotease</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rseP</name>
        <name evidence="11" type="ORF">HMPREF0766_12899</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993723.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12899"/>
    <dbReference type="EnsemblBacteria" id="EFK57826">
        <property type="protein sequence ID" value="EFK57826"/>
        <property type="gene ID" value="HMPREF0766_12899"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0750">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025778_0_0_10"/>
    <dbReference type="OrthoDB" id="1395197at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00054">
        <property type="entry name" value="TIGR00054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="109"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="212"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK57826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="441" mass="48717" checksum="6AC41B120D40E405" modified="2010-10-05" version="1">MGVLIMIGQVVLGLSILIVLHELGHFLAARAFGIKVEKFYLFFDAWGVKLFKFNYKGCEYGIGWLPLGGYVKIAGMIDESMDTEQLKGEPQPWEFRSKPAWQRLIVMLGGIIVNIVVGVVVYWMLAFSQGESNFDNQKLVNGVVPGIIGKQIGIQTGDRIVAIDGQKVGFFKELLSSKVLMGNTNLTIERNGETKEIHVPADILNAVADHKANEFVQIRTRMTAVDNVVKGSEAARMGLVKGDSIIAVNEVSVRFFDEFKSILEKDAGKPVMLTLVRKGQTITVKGQVDKDGTLGFNRNYDYSLPLVITEYSLAEAFPVGAKQAFSVITDNIKGFGKIFRGEIRADKALSGPVGIATLFGTEVDWVRFWSLVGMLSMALAFMNLLPIPALDGGHVIFLLVEMIQGKPLSEKFLEKAQMVGFFILLALMIFVFGNDIFKLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPN4</accession>
    <name>D7VPN4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hsp20/alpha crystallin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hsp20</name>
        <name evidence="4" type="ORF">HMPREF0766_12954</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993815.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12954"/>
    <dbReference type="EnsemblBacteria" id="EFK57881">
        <property type="protein sequence ID" value="EFK57881"/>
        <property type="gene ID" value="HMPREF0766_12954"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_8_4_10"/>
    <dbReference type="OrthoDB" id="1523369at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="35"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="147" mass="16526" checksum="9EA530CC5E539551" modified="2010-10-05" version="1">MALLKFPTKAVNTDAVNPFVNSVFDNLFNDSFITDRLVTRVPAVNIAEAEDSFQIELAAPGLQKSDFKINVDKNMMTISAEKTSETETEQKLFSKREFNYSSFTRSFTLPDTVDYSNIEASYENGILVVKVGKKEEAIVAKRLIEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPP6</accession>
    <name>D7VPP6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993833.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12966"/>
    <dbReference type="EnsemblBacteria" id="EFK57893">
        <property type="protein sequence ID" value="EFK57893"/>
        <property type="gene ID" value="HMPREF0766_12966"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_6_10"/>
    <dbReference type="OrthoDB" id="1616572at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="17"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="285" mass="31864" checksum="5BF764B805B7581B" modified="2010-10-05" version="1">MINMEVTKNNKTILVIGGSGKNGSRVVRKLRELNYPTFSTVRKGNTAQADVRIFEWKDISTWEAALTDIDSIYIVHPDTSMPEAYTEIKELTEKSVEMGVTRLVLLSGRGQQSVVECEDAIRNSGLKWTIVRSAWFNQNFTEGHFAAGIQHGELTFMADKVKEPFVDLEDLSDVIVQCLIDDKHDHHIYEVTGSTLYSFEEAVQIIGAAKGKPVRYIHADADNYYELLVKHGLPQDLATHMIGAFAEILDGRNANIGDGIEKVLGRPPVSFTTFVKNNFQTDEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPT5</accession>
    <name>D7VPT5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GroES-like protein</fullName>
            <ecNumber evidence="4">1.1.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">adh</name>
        <name evidence="4" type="ORF">HMPREF0766_13005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13005"/>
    <dbReference type="EnsemblBacteria" id="EFK57932">
        <property type="protein sequence ID" value="EFK57932"/>
        <property type="gene ID" value="HMPREF0766_13005"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="23"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="358" mass="39111" checksum="9EEC742CA1F9DF91" modified="2010-10-05" version="1">MLALKNKQYTMITTKGYAAQTPTSDLAEWEFERREVGPHDVQFDIQYCGVCHSDLHQIRNDWFPGIFPMVPGHEIVGKVIKVGEHVTRFKVGDLAGTGCMVDSCRTCPNCQEGLEQYCDNGNIQTYNGVNKYTDGAPTYGGYSNTIVVNEDFVLHVPASLSLAATAPLLCAGITTYSPLRHWKVGKGHKLAVLGLGGLGHMAVKFGVAFGAEVTVLSTSPNKEADARKLGAHHFVVTTDPEQVAKAKNSFDFILDTVSAEHDMAMYMSLLRTNGVHIIVGVPPEAHKIPAFAFIDGRKSVAGSGIGGIAETQEMLDFCAEHQIVSDIELIDIKDIQTAYDRMIKGDVRYRFVIDMATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPT7</accession>
    <name>D7VPT7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993890.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13007"/>
    <dbReference type="EnsemblBacteria" id="EFK57934">
        <property type="protein sequence ID" value="EFK57934"/>
        <property type="gene ID" value="HMPREF0766_13007"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_4_2_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="115"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="185" mass="22024" checksum="5DCD5EBDD513AE65" modified="2010-10-05" version="1">MSWSNFIHGDAKAFESIYQQYIDDLFAFGLKFHADRETVLDCIHDLFLDLYDNPRIAKDVEVKYYLFSALRRRILKRKKADVYEPLESLPENVWAIGSHELDLILKENQDINVQKVKQEIDKLPKRQKEVLYLKYYMEFSYEEIASIMNVSVESCRTLSYRAFRVLKSHMGPLEYMSALIYIFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPT9</accession>
    <name>D7VPT9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sigma factor regulatory protein, FecR/PupR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993893.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13009"/>
    <dbReference type="EnsemblBacteria" id="EFK57936">
        <property type="protein sequence ID" value="EFK57936"/>
        <property type="gene ID" value="HMPREF0766_13009"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050192_1_1_10"/>
    <dbReference type="OrthoDB" id="1381035at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="133"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="349" mass="39934" checksum="1F3590CDA7F542E5" modified="2010-10-05" version="1">MEKHRNQLKKIFDLPENEQLTDPERAELMASVIRRGRQKRHRSIYLMLTAACVLLIGSLFIFYPRADDTSFDLSRVAEFNQKRFESTDQTQIVKSKIFISPITNDPGLLSGDVSYAADSMLDLSDESAASYTTIYVPNGHRQEVTLTDGTRVWLNAGSYLTMDKNMRGKERRVYLNGEAYFDVTHTGKPFFVQMKAHTVEVVGTSFNINSYERDQQTTVELITGKVLFHSNSKGFEKIAMSPGQRIAAYENPGRVVIDKSGVAQDILWTKKQISLNKIRLQDLFRKIERLYNVSIDADPALDNIDLSYSGRLDLREDVVAVLKNIYELRDYQIILKEKEVTIRKPKSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPX8</accession>
    <name>D7VPX8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacteroidetes-specific putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993936.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13032"/>
    <dbReference type="EnsemblBacteria" id="EFK55829">
        <property type="protein sequence ID" value="EFK55829"/>
        <property type="gene ID" value="HMPREF0766_13032"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068235_0_1_10"/>
    <dbReference type="OrthoDB" id="1677536at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019861">
        <property type="entry name" value="PorP/SprF_Bacteroidetes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11751">
        <property type="entry name" value="PorP_SprF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03519">
        <property type="entry name" value="T9SS_PorP_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107424" evidence="1">
        <location>
            <begin position="23"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="337" mass="37439" checksum="8F84BB6C3C06726B" modified="2010-10-05" version="1">MKYGKYAVIIVAGLLGLTKVSAQQSIQFTQYMFNSMSVNPAYAGYKEEWFAQVGLRSQWTGWSGAPKTGTVSIDGVLDPYSKRHGVGLNVTADKLGAQAATSAYANYAFRLQLDDEDTQRLSLGVAGGVTQYSLDGNKLDANDPNDPIIPDGKISDWVPDIRLGVYYYNPKWYAGLSVQDLFNGTNSGTDYRFNQNTSESLYRTISGYFIAGALLELSRGVHLRPSMLIKEDFKGPTSLDVNAMFVFNGKFWIGAGYRTRARLFNRQYQDRSVDKLSSMNAITGIAQFYATDRLRIGYSYDAMINKLSGVQNGSHEITLGITFGRRGATQYLNPRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQA7</accession>
    <name>D7VQA7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994142.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13161"/>
    <dbReference type="EnsemblBacteria" id="EFK55958">
        <property type="protein sequence ID" value="EFK55958"/>
        <property type="gene ID" value="HMPREF0766_13161"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1819">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048991_0_0_10"/>
    <dbReference type="OrthoDB" id="1165736at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="328" mass="37277" checksum="AEA5404714F527B8" modified="2010-10-05" version="1">MKVLYAVQGTGNGHLCRAMDIVPCLRKTADVDVLVSGIQADINLPFEVKYKLHGLSFIFGKSGGVDLWKTFMSSTVRKFTQEIKSLPIENYDLIINDFEPISAWACYSKDKPCIGLSHQIGALDASSPKPEEKDMLGKFIMKNYAPSSKSYGFHFKSYNDHIFTPVIRQSIRNIEPEDHGHYTVYLPSYDDAHLLKHLSKFPDIRWEVFSKHNSKPFRMRNVFIQPINSEAFVKSMSTASGVLCGAGFETPAEALFLNKKLLVIPMKNQYEQHLNAAALEEMGVPVISSLKQKNEYAIEAWLNSRNKVEVHYPDYTQEIVDNILNKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQC4</accession>
    <name>D7VQC4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0766_13178</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994186.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13178"/>
    <dbReference type="EnsemblBacteria" id="EFK55975">
        <property type="protein sequence ID" value="EFK55975"/>
        <property type="gene ID" value="HMPREF0766_13178"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_10"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="25"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="347"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="380"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK55975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="593" mass="67223" checksum="F55C83B12F4B199A" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQC7</accession>
    <name>D7VQC7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydroorotate dehydrogenase (quinone)</fullName>
            <ecNumber evidence="11">1.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DHOdehase</fullName>
            <shortName evidence="11">DHOD</shortName>
            <shortName evidence="11">DHODase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">pyrD</name>
        <name evidence="13" type="ORF">HMPREF0766_13181</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(S)-dihydroorotate + a quinone = a quinol + orotate</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="11">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11">Cell membrane</location>
            <topology evidence="3 11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="11"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994196.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13181"/>
    <dbReference type="EnsemblBacteria" id="EFK55978">
        <property type="protein sequence ID" value="EFK55978"/>
        <property type="gene ID" value="HMPREF0766_13181"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013640_2_0_10"/>
    <dbReference type="OrthoDB" id="1109542at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00225">
        <property type="entry name" value="DHO_dh_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11" id="KW-0288">FMN</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="12">
        <location>
            <begin position="49"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="115"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="248"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="321"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFK55978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="344" mass="37773" checksum="DDBCF9A66A255E9A" modified="2010-10-05" version="1">MYKLIKPFFFSMNPESAHHTVTGGLQTFTKIWGAKSLLKSIYTVEDKRLEREVFGLKFKNPVGLAAGFDKNGEYIDEMVNFGFGFIEIGTVTPRPQPGNDKPRMFRLVSDKALINRMGFNNQGADVAAGRLRHLKQRGNIIIGGNIGKNKVTPNEDAVLDYIYCFKALFDYVDYFVVNVSSPNTPGLRDLQEKEPLMNILRQLMDINNKDGVSKPILLKIAPDLTDSQLDDIVEIVQETKIAGVIATNTTVSRDGLQSDPNLVKETGGVSGKPLTNRSTVVIRYLADKSSRSFPIIGVGGIHSAQDAIEKLDAGASLIQVYTGFIYEGPGLISDICKGILKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQH7</accession>
    <name>D7VQH7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxalase family protein</fullName>
            <ecNumber evidence="3">3.4.21.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.26" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994297.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13231"/>
    <dbReference type="EnsemblBacteria" id="EFK56028">
        <property type="protein sequence ID" value="EFK56028"/>
        <property type="gene ID" value="HMPREF0766_13231"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107214_1_0_10"/>
    <dbReference type="OrthoDB" id="1900922at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107150" evidence="1">
        <location>
            <begin position="26"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="36"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="164" mass="18468" checksum="DC92FB75E5667ADC" modified="2010-10-05" version="1">MKKSTFICLTLIPLLSTMVNNPVYAQSSTLTKAKIKAVQFRIARPTNNLKEVVRFYTEGLGLPQIGAFKGHQGYDGVMLGLPDSGHHLEFTQYADPVSLPAPTKENLLVLYYDIPEQYEAANKRLQDMNIQAVAPENPYWEGKSKTYEDPDGWRVVLFNGIYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQI5</accession>
    <name>D7VQI5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13239"/>
    <dbReference type="EnsemblBacteria" id="EFK56036">
        <property type="protein sequence ID" value="EFK56036"/>
        <property type="gene ID" value="HMPREF0766_13239"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1420653_0_0_10"/>
    <dbReference type="OrthoDB" id="2143384at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="200" mass="23344" checksum="9D98FFAB6BE9D9D2" modified="2010-10-05" version="1">MTFLYSRKIITVLLVTGICAAFVACNSYKFYQNKDYSFYQPDFRLSDTSMLRTDGVYVLQEIWTSQRDTKRTVTAKEREIYKFYPAGQVNMVLDPEDTTSRKGTYAAAFNNSIADQIAKKSRTLFQSYYKTEGDRLVVQRMNTPLAQFNYTYFTVKKDTLIQVSSTIDGGGQIRDKYYTDYYKAYYIFVPVKDTFTPPNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQQ8</accession>
    <name>D7VQQ8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, aldo/keto reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994435.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13312"/>
    <dbReference type="EnsemblBacteria" id="EFK56109">
        <property type="protein sequence ID" value="EFK56109"/>
        <property type="gene ID" value="HMPREF0766_13312"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_5_0_10"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="PTHR42686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="27"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="346" mass="38956" checksum="67F6FEA3FC038617" modified="2010-10-05" version="1">MYGIAIAENSYTNFILLMKTHFELKYPLGLGGVAIGTGFEPLSDEESYHILETAWNQGIRYYDTSPWYGLTKSERRFGDFLRQKSRDEFVFSTKIGRLFDAVDEADVPPTMWKAPLAYDFRHDYTADATARSIEESLSRTGLDHIDIVFVHDLSEDQVGDRYDYYLQQAEKGAFRLLSDYRDQGIIKAWGMGVNKIEPILDCIRIADPDICLSATQYSILEHEDAVDRLLPVVREHGVKLVSGAGFNSGYIGGRERYNYKDVIPKGMAEKRARIAAIAQQYGTDLIAAAIQFVLAADEFVSIIPGASRPGQVLDNCRAIQSSISHDFWKELKHEGLIYTQAQVPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQR9</accession>
    <name>D7VQR9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_13323</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994448.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13323"/>
    <dbReference type="EnsemblBacteria" id="EFK56120">
        <property type="protein sequence ID" value="EFK56120"/>
        <property type="gene ID" value="HMPREF0766_13323"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_10"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="216"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="272"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK56120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="489" mass="56067" checksum="13C7F5F68E30D8D5" modified="2010-10-05" version="1">MILIVDDKSENIYSLKRLLESKDFLVDTALSGEEALKKVLKNNYALIILDVQMPGIDGFEVAETLSGFSKTKEIPIIFLSAVNTDKKFITKGYESGGIDYVTKPVDPDILLLKVKTFYRLYEQTLALNETQQALISEIETRKKAEMKLKERVDHLHFTLESLPQIAFTANAEGQIEFVNEKWFKYSLSSEIFPKTHPDDKNIRDEWLLAMATGNSLELEVRIKEIDADIFRFHLLRIIPIREQEIVVKWVGTFTDIDDQKQIEKKKDEFLSIASHELKTPLTSIKAYIQLLERTLNAEQNSATSKYLSTVQNQVSKLNSLIADLLDISKIDNGKLKMNKKLFNFENLLSNVVDTIYHTHENSNIRIEREGDVIDQPVLGDEIRIEQVLINYLTNAIKYSPDSKRVIIRTEQENTQIKVDVTDFGIGIPEHKQKNIFNKFYRVEESSLKFQGLGIGLYICSEIIRQHNGTFGIQSQTGQGSTFYFTIPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR18</accession>
    <name>D7VR18_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994578.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56219">
        <property type="protein sequence ID" value="EFK56219"/>
        <property type="gene ID" value="HMPREF0766_13422"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2358269_0_0_10"/>
    <dbReference type="OrthoDB" id="1630127at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="96" mass="11385" checksum="A965338F052EF25F" modified="2010-10-05" version="1">MELLAKRNYYVTFKRILETVHAAGHKLTRQREIIIQTICKLKIVDDVEQIWLRLKDEFDIALATIYSTIKLLCSLGLMGIRYQTDTRKRIYELANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR23</accession>
    <name>D7VR23_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron chelate uptake ABC transporter, FeCT family, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_13427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994588.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13427"/>
    <dbReference type="EnsemblBacteria" id="EFK56224">
        <property type="protein sequence ID" value="EFK56224"/>
        <property type="gene ID" value="HMPREF0766_13427"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_3_0_10"/>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK56224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="313" mass="34403" checksum="9DDA5BE36371ADFF" modified="2010-10-05" version="1">MRILFLIVLILLAIASLFTGVKEISLSEIFHLSEDQLLVFTISRIPRTAALILAGGGLSIVGFIMQQITQNKFVSPTTAGSLEAAKMGILFSLLLIPQESLVYKMLFALCFTFAASMLFMAMVRRIRFRSTVFIPLIGILFGNILGAISTFFAYKHNIVQNVQGWSMGDFSAVLQGQYETIYIILPAVLISYVYADRFTIAGMGESFSKNLGLSYLTVVNLGLFIVSVTVSVTIVTVGAIPFLGLIIPNIVSMIYGDNLRKNLPYTALIGAIFLLVCDILGRILIYPYEIPIGLMVGITGGIIFFLLILKRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR50</accession>
    <name>D7VR50_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MutS domain V protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_13454</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994618.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13454"/>
    <dbReference type="EnsemblBacteria" id="EFK56251">
        <property type="protein sequence ID" value="EFK56251"/>
        <property type="gene ID" value="HMPREF0766_13454"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_629554_0_0_10"/>
    <dbReference type="OrthoDB" id="596088at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="4">
        <location>
            <begin position="260"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="449" mass="52065" checksum="4704B2334F768444" modified="2010-10-05" version="1">MFRIDKQTLSDLNALDWNSRSLLRFFNHTLTVGGSDMLYSYFLHPLDNVEEIRQRQEAITQLADWDIDSLFDKYMMIDLERYLGLPNELHSDNPFLFYLEKFSSNFMSKSSKKERILIKQSVAEIAMIILNVGAWLEKAVTSANPAGVLKTYSDNFKNLSADLDMEELKVLSKGKNPILLLIKYDYLFRNLKRLEVKEIFTIYYNIDALRSVAKSFDKTNMSFPDFSTDQSQNILLQIKDLYNLALENPVKNNITVENCRNIWFLTGANMTGKSTLLKSMGASIYLAHMGFPVPAKSMQIQLFRGLMTTINLGDNLASGYSHFFNEVYRVKRIAESIRDEGKMIVMFDELFKGTNYEDSYEATRKLIESISKLEDSIFIISSHITELEQELKNNDRVTFKYLKTTMQNGTNISFTYQLTEGVDKTKLGMWFLEKEDVFNTFKEIKSRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRC9</accession>
    <name>D7VRC9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994717.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13533"/>
    <dbReference type="EnsemblBacteria" id="EFK56330">
        <property type="protein sequence ID" value="EFK56330"/>
        <property type="gene ID" value="HMPREF0766_13533"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032YQP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2289850_0_0_10"/>
    <dbReference type="OrthoDB" id="1997313at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="102" mass="11789" checksum="D8BFA8B4C6F82DBD" modified="2010-10-05" version="1">METRHNYETADVALAKLQQMGYNIDYNIEFDEIYSNTEEYQIDYLYRYEGSSNPDDESTVYGISNPTNGKKGVFVVGNLSLIEGKKRDIILNLELKYKNKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRD2</accession>
    <name>D7VRD2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13536"/>
    <dbReference type="EnsemblBacteria" id="EFK56333">
        <property type="protein sequence ID" value="EFK56333"/>
        <property type="gene ID" value="HMPREF0766_13536"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50333AF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1785661_0_0_10"/>
    <dbReference type="OrthoDB" id="2016576at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="145" mass="16890" checksum="9CFC7EB66A710658" modified="2010-10-05" version="1">MKKIIFRFSLINIGLGIVLFLLYRVIIDRLNPPDTTTLEKIYTVMDIFMQIILSSVYLVAIAVSSLLFFLNQIDRIRNNYYLSFLTFSGLPLFFVLFVGVNIALDIHQYDIIPSSIKMLLGFSILYLLCTIIEFLIFRSKIKKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRH9</accession>
    <name>D7VRH9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DsbA-like protein</fullName>
            <ecNumber evidence="2">5.3.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dsb</name>
        <name evidence="2" type="ORF">HMPREF0766_13583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994778.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56380">
        <property type="protein sequence ID" value="EFK56380"/>
        <property type="gene ID" value="HMPREF0766_13583"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2761">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069253_0_2_10"/>
    <dbReference type="OrthoDB" id="996965at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="10"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="243" mass="27399" checksum="0B8B808192E00F81" modified="2010-10-05" version="1">MNTIQTSKMQVEIWSDIMCPFCYIGKRNFEGALSKFANSENIEIIWKSFQLDPTLPEKEEFDHIQYLVQRKGMPANQVHAMLDQVTQTAKNAGLDYDFDHVVTVNSFNAHRVIQFAKTKGLGDEIEERFFKAYFTEGKDIADRKVLSALGQEIGLTEDDIEQALSNDEYAYRVTQDIQEAQSIGVRGVPFFVFDRKYAVSGAQPTQAFADTLNKSFAEWAAKNPISPFIVSDGPSCSPDGHCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRJ1</accession>
    <name>D7VRJ1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fkuA</name>
        <name evidence="5" type="ORF">HMPREF0766_13595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994791.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13595"/>
    <dbReference type="EnsemblBacteria" id="EFK56392">
        <property type="protein sequence ID" value="EFK56392"/>
        <property type="gene ID" value="HMPREF0766_13595"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059988_1_3_10"/>
    <dbReference type="OrthoDB" id="1423012at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="3"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="229" mass="26321" checksum="0E1BB798A02E575B" modified="2010-10-05" version="1">MSIAANIEEINQEIKSLGVTLVAVSKTKPNEDILQAYEAGQRVFGENMVQELVEKQEQLPKDIEWHLIGHLQTNKVKYIAPFIHMIESVDSIKLLKEINKHALKHDRIIDCLLQVYIADEDTKFGLDHTELIELLRDDEFSSLKNIRIRGLMGIATNTENEKVIKEEFYELKMLFDGVKSSFFRKEDTFDTLSMGMSSDYRLAIEQGSTMIRLGSTVFGKRVIKHFKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRN5</accession>
    <name>D7VRN5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclic nucleotide-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994890.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13639"/>
    <dbReference type="EnsemblBacteria" id="EFK56436">
        <property type="protein sequence ID" value="EFK56436"/>
        <property type="gene ID" value="HMPREF0766_13639"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1276944_0_0_10"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="220" mass="25616" checksum="EB5886485BC640F6" modified="2010-10-05" version="1">MEKLVDETKSNCSYTKGKVRKELEHLLNKHGIKSSLSKQMFYEKCKIRTLVKGSAVFFEGKVNNSEYVLLSGILHRYNSCEKENVVTTGFYIPKALITPHFLRTKNNKSIFGLHAVTDVVIAEISLKEYKRLRKLFKEFEAFERHYIQEEILHISHNKVFLRCYDAKERLLFFRRQFPDLENSIPHSLIASYLGITHVSLSRLRGEIAKSKITVEESNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRS2</accession>
    <name>D7VRS2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">msrB</name>
        <name evidence="5" type="ORF">HMPREF0766_13676</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994985.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13676"/>
    <dbReference type="EnsemblBacteria" id="EFK56473">
        <property type="protein sequence ID" value="EFK56473"/>
        <property type="gene ID" value="HMPREF0766_13676"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_8_2_10"/>
    <dbReference type="OrthoDB" id="1650261at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MsrB" evidence="4">
        <location>
            <begin position="49"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="174" mass="20029" checksum="C44F1220A0C55DAA" modified="2010-10-05" version="1">MKNYLIITRRIILMAILLVCIGINSNAQQTASRNPYYSRTDTKKLNIKNSEWKKILDPDLYAVAREAQTERAFTGKYYEYDVKGTYYCAVCGNPLFRSTAKFSSTCGWPSFYEPLKKNSVIYKQDNSYNMVRTEVLCGRCNSHLGHIFDDGPPPTGKRFCMNSISLEFEPDQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS90</accession>
    <name>D7VS90_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13844</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995415.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13844"/>
    <dbReference type="EnsemblBacteria" id="EFK56641">
        <property type="protein sequence ID" value="EFK56641"/>
        <property type="gene ID" value="HMPREF0766_13844"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_14_1_10"/>
    <dbReference type="OrthoDB" id="1958442at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="136"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="241" mass="28053" checksum="69BAD378E38D9D64" modified="2010-10-05" version="1">MNCIIVDDEPLAREEMQSLISEVSDIVISGKFSNASQALSFLKDHDTDLIFLDIQMPFVTGIDFAKQISGQCLIIFTTAYPQYALKSYELDALDYLLKPIEKKRLEKAIHKFISYKNLLSDATVKNTVEANTEDFLFIKSERRFYKIYFQDIRFVEGLKDYVVIYTKSQKLITAMNLKIMHQKLPARSFQRVSKSYVVNVDFIDSFDNHTIYMDENEIPLGEVYKKEFFERYLGGPLNSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSK0</accession>
    <name>D7VSK0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995611.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13954"/>
    <dbReference type="EnsemblBacteria" id="EFK56751">
        <property type="protein sequence ID" value="EFK56751"/>
        <property type="gene ID" value="HMPREF0766_13954"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_2_1_10"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="359" mass="40335" checksum="12123C8C79C444B5" modified="2010-10-05" version="1">MQITKDQKHILESQIHAAIAQQQLTSAQLDLAYQEKWFKIWVPQELGGLGLKLSEGVRFLRDLAYIDGSLAWTITLCSGANLFVGFIDTEKGKSVFSDAKVCFGGSGMCSGRAYKTEEGYLVSGVWKYATGSPHLTHFTANVPVFDGDAACADEKGQTSFITIFADHTDAELIRDWNTFGLESTASHSFKLDNVFIADNQVYSLVPEKATLADPIYQYPFMPFAALTLLANYMGMFERFLDLVVELFQHKSKQSGWQEKFGVSVKDHLDQTVVLYDKMQQEIWTEMDISWSKLVDGESDAVCYARIETQSRDMVSFIRSKVTAFFPYCGIAAAQRESELNIVFRNIFTASQHSLLLKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSN8</accession>
    <name>D7VSN8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative menaquinone biosynthesis protein, SCO4550 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_13992</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995678.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13992"/>
    <dbReference type="EnsemblBacteria" id="EFK56789">
        <property type="protein sequence ID" value="EFK56789"/>
        <property type="gene ID" value="HMPREF0766_13992"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040406_1_0_10"/>
    <dbReference type="OrthoDB" id="419725at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="50"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK56789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="374" mass="42646" checksum="C6BAFD35586A9605" modified="2010-10-05" version="1">MNINSLLERALNFEFLSKEEGIYLYHHAATADLTYVANECRKVQVPHGKVTWQIDRNVNTTNVCIANCKFCNFFRRPGHDESYITDIETYKQKIEETFKYGGDQLLLQGGHHPDLGLTFYADIFKKLKELYPTLKLHSLGPPEIAHIAKLEGMTHIDVLQQLKESGLDSLPGAGAEILNDRVRRLISKGKCGGKEWLDVMRAAHQLNLPTSATMMFGHIETIEERFEHLVWIREVQSEKPQDAYGFIAFIPWPFQDDGTLLKRLRGITNNVTGEEYIRMIALSRIMLPNIKNIQASWLTVGKRTAELCLHAGANDFGSIMIEENVVSAAGAPHRFTSKSIQDAIREAGFEPQLRTQTYQFRDLPEHMEEQVINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSV5</accession>
    <name>D7VSV5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="9">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 15" type="primary">leuS</name>
        <name evidence="15" type="ORF">HMPREF0766_14059</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="9"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995838.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14059"/>
    <dbReference type="EnsemblBacteria" id="EFK56856">
        <property type="protein sequence ID" value="EFK56856"/>
        <property type="gene ID" value="HMPREF0766_14059"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0495">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004427_0_0_10"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="13">
        <location>
            <begin position="38"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="14">
        <location>
            <begin position="277"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="11">
        <location>
            <begin position="699"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="12">
        <location>
            <begin position="779"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="700"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="703"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFK56856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="927" mass="106683" checksum="5F901226E33D57EA" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSW2</accession>
    <name>D7VSW2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995855.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14066"/>
    <dbReference type="EnsemblBacteria" id="EFK56863">
        <property type="protein sequence ID" value="EFK56863"/>
        <property type="gene ID" value="HMPREF0766_14066"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_1_10"/>
    <dbReference type="OrthoDB" id="1320028at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="472" mass="53594" checksum="4C4BCC76559C1986" modified="2010-10-05" version="1">MIRPWNLEMQLDFQAEKSVYLQIADAIIEAIRSGRLKKGEALPGTRSLSEHIGVNRNTVVEAVNVLQNEGWIITKERAGTFVAEEPPVRQHNTPDLAVPVKTDAAPDPIYTICFDDGYPDSRVAPVKELARAYRQIFNQKARWQMMGYTNALGDEAFRAAIARMLNHNRGMKIDIPHICITRGSQMALYLAAQSLIQKGDYVLVEDPGYHPAWEAFEHAGARLLPVRVDEDGLIISDIIRHLQSGISIKAIYTTPHHQYPTTVTLSLSRRAELIRLSNQYGFTIIEDDYDNEFHFGRRPILPLSSYNEIQNYIYIGTMSKVVAPALRIGYLVSEASYIQKIGALRKIIDVQGDNIMEQAVLQLIEDGTIKKHLKKMTLYYRNKRDTCIRLLDQYMKDKADYHLPDGGLACWVVPRQQQLVRDLEEKLKEKGIRISGPEKYNLGQDTQGLRLSYGALSETQLEEGIRVIADFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSW6</accession>
    <name>D7VSW6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter, betaine/carnitine/choline family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">betT</name>
        <name evidence="7" type="ORF">HMPREF0766_14070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995860.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14070"/>
    <dbReference type="EnsemblBacteria" id="EFK56867">
        <property type="protein sequence ID" value="EFK56867"/>
        <property type="gene ID" value="HMPREF0766_14070"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010118_3_1_10"/>
    <dbReference type="OrthoDB" id="1217683at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018093">
        <property type="entry name" value="BCCT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000060">
        <property type="entry name" value="BCCT_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30047">
        <property type="entry name" value="PTHR30047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02028">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00842">
        <property type="entry name" value="bcct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01303">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="673" mass="76920" checksum="587F61FEC445D5AE" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSX2</accession>
    <name>D7VSX2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma factor regulatory protein, FecR/PupR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_14076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995867.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14076"/>
    <dbReference type="EnsemblBacteria" id="EFK56873">
        <property type="protein sequence ID" value="EFK56873"/>
        <property type="gene ID" value="HMPREF0766_14076"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050192_1_0_10"/>
    <dbReference type="OrthoDB" id="1381035at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032508">
        <property type="entry name" value="FecR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16344">
        <property type="entry name" value="DUF4974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="188"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4974" evidence="3">
        <location>
            <begin position="331"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="400" mass="45682" checksum="D8B9AE0DDBDBE152" modified="2010-10-05" version="1">MENQYRIIYLLTGKRKGILNQEELVELAEWISKEESNRLFAERLADPKNQDESLNKLQYFADSQSLSRFKHTHQHLKPALRKSFIKNIPSRYWAAAILFIFCSVIALYFTISSQPVQQEDQLTRAGRDISPGKDKAILQLADGKHIALEELKNGESLDINGLRIVKSADGEISYSFSSASSDVHLTNRIVTPRGGQYKVRLSDGTRVWLGAESELEYPVQFESDKREVRLSGEAFFEVTHVQNKTNEKVPFQVKMALQTIEVLGTSFNVAAYPQDRTNRTTLVNGKIRVNTAYGSDVLRPGQQALVSKDGKNIQVYEVDVSNMDEWKNKSFRFEEESIQEIMNKVARWYDVDIIYEGKITEELFSGVVSKYENPANVLKLLELTGKVKFRIEGRRIIVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT62</accession>
    <name>D7VT62_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_14166</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002978443.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14166"/>
    <dbReference type="EnsemblBacteria" id="EFK56963">
        <property type="protein sequence ID" value="EFK56963"/>
        <property type="gene ID" value="HMPREF0766_14166"/>
    </dbReference>
    <dbReference type="GeneID" id="66690335"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_8_3_10"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="373" mass="42109" checksum="FA5886A55F924E9A" modified="2010-10-05" version="1">MRTLKFLLQKEFKQIFRNKALLPLIFVVPIVQLLILPLAADYEVKNINISIVDHDHSTYSQQLISKITASGYFQLADYGNSFQSAFNQIEKDKSDLILEIPQGFEKNLVRENEQKLFIAVNAINGVKAGLGGAYLAQIISAYNNDIRLQWVQPDKYNTAPVITVASSNWFNPFMNYRFFMVPGILVVLVTMVGAYMCALNIVKEKEVGTIEQINVTPIKKYQFVLGKLIPFWAIGMLIFSIGLFIVARFVYGIVPVGSLLLLYGYLSIYLIALLGLGLLISTFAETQQQAMSVAFFFIMIFMLMSGLFTPLDGMPQWAYIIAKSIPVTYFIEVVRMIILKGSGFSDIKYHFIIMIGFAVLLNGLAIWNYKKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT67</accession>
    <name>D7VT67_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996066.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14171"/>
    <dbReference type="EnsemblBacteria" id="EFK56968">
        <property type="protein sequence ID" value="EFK56968"/>
        <property type="gene ID" value="HMPREF0766_14171"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z86V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019967_0_0_10"/>
    <dbReference type="OrthoDB" id="760892at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025222">
        <property type="entry name" value="DUF3945"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025343">
        <property type="entry name" value="DUF4099"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13101">
        <property type="entry name" value="DUF3945"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13351">
        <property type="entry name" value="DUF4099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3945" evidence="2">
        <location>
            <begin position="263"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3945" evidence="2">
        <location>
            <begin position="366"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="487" mass="55487" checksum="954C321117BCBFDD" modified="2010-10-05" version="1">MSEETENKQQTPEQLSDILLVLDKQKNKIQAVTGIDENGKLKTTDPTKENQSQFMRVDKHGDLFSNFFSNFWRQLKNPTNFSFFKVSADEAVDKAKEMQKQVDNPTPEGEKEMKKNEVKAEPENEQKQENKNDMATTQTTPDTSEYRYKPEQIDWETMNNLGIGKERLEKMNLLDPLLRGYKTNDLVPVSVNLGGAIVRTDARLSLQTAPDGTVVAAIHGIRKEPNLNFEFFGHKFTDEDKKNLLETGNMGRVVDLTNSKTGELMPSIISVDRLTNELIALKTEFVKIPDEIKGVKLNDEQKQTLMEGKSLYLEGMISKKGDEFSANVQFNADKRYVEFLFDRSNNNQQTQENRQNNQQSQPQEAPRTFRGKELDDEQYNKFKAGQTVYIDGLIDKKGQKYQGYITLNKETGKTDFSFQNPDKLKAQAKPTEAHKTQTAVNSEGKTNEATKNIKEPLKSGQQTPKNEKQQEQQNKPKAPAKSKGVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTF9</accession>
    <name>D7VTF9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996330.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14263"/>
    <dbReference type="EnsemblBacteria" id="EFK57060">
        <property type="protein sequence ID" value="EFK57060"/>
        <property type="gene ID" value="HMPREF0766_14263"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1626019_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="163" mass="18827" checksum="657B35258E13C5A2" modified="2010-10-05" version="1">MLLIKTKMNKHKSAIVTFVLILCFLISLITGLSIAAFHDYRAGILLVFLSLYCIFVFRALLWYLMGEETISIDENHLIIVKKAGFFTQSRSFDLQKIKDLRYENHPYSFMDFFVSRTVLTSLAAYGVIAFEYDKIQRIGIGIEKEEAERIIVLIKMSLKANKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTP7</accession>
    <name>D7VTP7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001703.1">
        <property type="nucleotide sequence ID" value="NZ_GL379777.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14367"/>
    <dbReference type="EnsemblBacteria" id="EFK55806">
        <property type="protein sequence ID" value="EFK55806"/>
        <property type="gene ID" value="HMPREF0766_14367"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZRYA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2221551_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="106" mass="11223" checksum="92A684B97E79B709" modified="2010-10-05" version="1">MSGSGGFGGYELPAREKFDCLFSSVAVKVSSIDLNVLAELIVGNILELEISNSGSLILIDGNGQTLGSIMHHNTSDIINCIKQGNNYHGVVINITSPTCTVEITRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTQ3</accession>
    <name>D7VTQ3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosyl hydrolase family 2, TIM barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0766_14373</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001720.1">
        <property type="nucleotide sequence ID" value="NZ_GL379777.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14373"/>
    <dbReference type="EnsemblBacteria" id="EFK55812">
        <property type="protein sequence ID" value="EFK55812"/>
        <property type="gene ID" value="HMPREF0766_14373"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006501_5_0_10"/>
    <dbReference type="OrthoDB" id="1832114at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032311">
        <property type="entry name" value="DUF4982"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16355">
        <property type="entry name" value="DUF4982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107674" evidence="5">
        <location>
            <begin position="21"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="8">
        <location>
            <begin position="65"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="6">
        <location>
            <begin position="200"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="7">
        <location>
            <begin position="309"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4982" evidence="9">
        <location>
            <begin position="648"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="511"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK55812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="818" mass="93325" checksum="F9C7A7AB8071ECEA" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTV1</accession>
    <name>D7VTV1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="7">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">ddl</name>
        <name evidence="11" type="ORF">HMPREF0766_14421</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002255.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14421"/>
    <dbReference type="EnsemblBacteria" id="EFK55730">
        <property type="protein sequence ID" value="EFK55730"/>
        <property type="gene ID" value="HMPREF0766_14421"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039268_1_1_10"/>
    <dbReference type="OrthoDB" id="764798at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="122"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK55730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="334" mass="37375" checksum="8107EB7E63135911" modified="2010-10-05" version="1">MKAKIALLTGGYTGEAEVSFKSSAFVYSQLDHNKYDVYLITITKDHWFHVNEQGVKFTVNRENFTLPLDHETIRFDLAFILIHGTPGEDGRLQGYFDMLDIPYTSCDALTSSLTMNKGYTKAVLAGIPDLHMAKSVLLFEAQRAEAVATVQANLSLPYFVKPNAGGSSIGMTKVKTNEELAEAIDKAFDAENTGKQVIVEEFVTGREFSQGIYRNVEGLLTVLPATEVKTTREFFDYEAKYTPGLTEEITPADLTEEQQSRIAALLKEVYIRLNCKGMVRIDFFLENGTDKFYFIEINTIPGQTAQSFIPQQVRAAGMKETDFYGDLIEVALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTZ1</accession>
    <name>D7VTZ1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14461"/>
    <dbReference type="EnsemblBacteria" id="EFK55770">
        <property type="protein sequence ID" value="EFK55770"/>
        <property type="gene ID" value="HMPREF0766_14461"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3084856_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="52" mass="6055" checksum="27D710E81774CE38" modified="2010-10-05" version="1">MLVSGIYLYFTSSYKNEEDLIKRNFKTNSFFYSICLIILGMGLILLEFFGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGC0</accession>
    <name>D7VGC0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Copper-exporting ATPase</fullName>
            <ecNumber evidence="9">3.6.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0766_10039</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.4" evidence="9"/>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001919.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10039"/>
    <dbReference type="EnsemblBacteria" id="EFK60095">
        <property type="protein sequence ID" value="EFK60095"/>
        <property type="gene ID" value="HMPREF0766_10039"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_3_10"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="751"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="776"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="75"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK60095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="804" mass="87118" checksum="FF44D44FC8048C10" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHD7</accession>
    <name>D7VHD7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Export-related chaperone CsaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">csaA</name>
        <name evidence="5" type="ORF">HMPREF0766_10406</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997357.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10406"/>
    <dbReference type="EnsemblBacteria" id="EFK59489">
        <property type="protein sequence ID" value="EFK59489"/>
        <property type="gene ID" value="HMPREF0766_10406"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065946_2_1_10"/>
    <dbReference type="OrthoDB" id="2038415at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008231">
        <property type="entry name" value="CsaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF37">
        <property type="entry name" value="PTHR11586:SF37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02222">
        <property type="entry name" value="chap_CsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="112" mass="12442" checksum="97930A97A0E8EEF1" modified="2010-10-05" version="1">MEEISWADFEKVDLRVGTILEAVDFPKAKKPAYQLVVDFGEEIGIRKSSAQITVHYTKESLIGRQVVAVINFPKKQIANFMSECLVTGFADENGDIVLTAVERPLPNGSRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHJ1</accession>
    <name>D7VHJ1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rplD</name>
        <name evidence="7" type="ORF">HMPREF0766_10460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997499.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10460"/>
    <dbReference type="EnsemblBacteria" id="EFK59543">
        <property type="protein sequence ID" value="EFK59543"/>
        <property type="gene ID" value="HMPREF0766_10460"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041575_5_2_10"/>
    <dbReference type="OrthoDB" id="1572673at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="209" mass="22995" checksum="0442ED7BE27821C7" modified="2010-10-05" version="1">MEVKVLNLSGKETGAKVQLPESVFGLEPNDHAIYLDVKQYLANQRQGTHKSKQRNEIAGSTRKLHKQKGTGGARAGSIKSPLFNGGGRVFGPQPRDYSFKLNKKLKQLARKSALSYKAQENNIVVLDAVSFDTIKTKNYVSLVAALNVADEKTLLVLPAYDNNVYLSSRNLKKAKVVSADQLNTYDVLNATKLLLTTDSVKTLEEAFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHN7</accession>
    <name>D7VHN7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_10506</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997583.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10506"/>
    <dbReference type="EnsemblBacteria" id="EFK59589">
        <property type="protein sequence ID" value="EFK59589"/>
        <property type="gene ID" value="HMPREF0766_10506"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_378515_0_0_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107221" evidence="5">
        <location>
            <begin position="21"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="118"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="359"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="811" mass="92183" checksum="3936ED855DE3CD54" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHR6</accession>
    <name>D7VHR6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fthC</name>
        <name evidence="4" type="ORF">HMPREF0766_10535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997663.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10535"/>
    <dbReference type="EnsemblBacteria" id="EFK59618">
        <property type="protein sequence ID" value="EFK59618"/>
        <property type="gene ID" value="HMPREF0766_10535"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066245_0_2_10"/>
    <dbReference type="OrthoDB" id="1816478at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="3"/>
            <end position="7"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="134"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="193" mass="22429" checksum="45E919C69F5998F3" modified="2010-10-05" version="1">MTKQELRQLYRSERQQLSVDELRTFNHQLLEYLKGIDWSKCQYCHVYLPINRNQEPDTLAFISWMQEVFPSVRLVISQSHADDRSMSHYLLDNTTTYLENKWGIPEPDSGTPVDEKLLDVVLVPLLICDQSGNRVGYGKGFYDRFLKKCRPDVQKTGLSFFEPVEKIADVDPYDIALDCCITPRHVIYFKSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHR9</accession>
    <name>D7VHR9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.129</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lpxA</name>
        <name evidence="7" type="ORF">HMPREF0766_10538</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.129" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997669.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10538"/>
    <dbReference type="EnsemblBacteria" id="EFK59621">
        <property type="protein sequence ID" value="EFK59621"/>
        <property type="gene ID" value="HMPREF0766_10538"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1043">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061249_0_0_10"/>
    <dbReference type="OrthoDB" id="971098at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008780">
        <property type="term" value="F:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03351">
        <property type="entry name" value="LbH_UDP-GlcNAc_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029098">
        <property type="entry name" value="Acetyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037157">
        <property type="entry name" value="Acetyltransf_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010137">
        <property type="entry name" value="Lipid_A_LpxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43480">
        <property type="entry name" value="PTHR43480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13720">
        <property type="entry name" value="Acetyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000456">
        <property type="entry name" value="UDP-GlcNAc_acltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01852">
        <property type="entry name" value="lipid_A_lpxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyltransf_11" evidence="6">
        <location>
            <begin position="173"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="264" mass="28817" checksum="C6F8391A0E296646" modified="2010-10-05" version="1">MIQPLAYIHPEARIAQNVVVEPFTTIHKDVVIGEGTWIGSNVTIMNGARIGKNCKIYPGAVISGEPQDLKFEGEVTVAEIGDNTTIRECVTINRGTKDRYKTVIGKNCLIQAYSHIAHDCIIGDNCIFSNSSTLAGHITIGDYVVLAGMVAVHQFVKIGSHAFVSGGSLVRKDVPPFIKAAREPITYAGINSVGLRRRGFSNEQINEIQGIYRVLFIQNGNLSKALDIVETEFKATETRDEILTFVRNSNRGIIKGFGQGRASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHT6</accession>
    <name>D7VHT6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bacillithiol system protein YtxJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ytxJ</name>
        <name evidence="1" type="ORF">HMPREF0766_10555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997713.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10555"/>
    <dbReference type="EnsemblBacteria" id="EFK59638">
        <property type="protein sequence ID" value="EFK59638"/>
        <property type="gene ID" value="HMPREF0766_10555"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153787_0_0_10"/>
    <dbReference type="OrthoDB" id="1740395at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022551">
        <property type="entry name" value="BrxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11009">
        <property type="entry name" value="DUF2847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04019">
        <property type="entry name" value="B_thiol_YtxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="110" mass="12445" checksum="0E8F6F048EAA8F1A" modified="2010-10-05" version="1">MNWKNITSVTQLDDIIADNQVHAIFKHSTRCPVSSMAKRSLEFNEDLLPEGASIFYLDLIAHRDVSNAIAEKWNIRHESPQVLVIKGTEALYNASHENIDMADIAKFFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHU6</accession>
    <name>D7VHU6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997744.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10565"/>
    <dbReference type="EnsemblBacteria" id="EFK59648">
        <property type="protein sequence ID" value="EFK59648"/>
        <property type="gene ID" value="HMPREF0766_10565"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1626021_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="163" mass="19095" checksum="92A2A74CABEC3415" modified="2010-10-05" version="1">MKINQKYLWILGIGIFLYLVFPFMKDLLSPGSNVYSKKYRIDMERDTLLNLLNKFNANNEPKDSSYFSTQENPYFYYGPVFDRKHDKVFYIDIPNPSIEQKGSEIHLLSMKTSLNEVAMVNGKPKNKEEKKRENAIKDFETNILDSLKITYTKIDFLTSLGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHZ1</accession>
    <name>D7VHZ1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997851.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10610"/>
    <dbReference type="EnsemblBacteria" id="EFK59693">
        <property type="protein sequence ID" value="EFK59693"/>
        <property type="gene ID" value="HMPREF0766_10610"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2059933_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="119" mass="13181" checksum="261412D2BE85F436" modified="2010-10-05" version="1">MAKIIIYMVFIIFISVFSSCPFKLAIKALNSEQEDIALPSGGTTTALTKGSVSVTCANMTRVRSHSGHSSPSFLAPSFILYFHNIGSLYRDIRVEQYTTGTEYYSSPTPTYLLNRTLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHZ3</accession>
    <name>D7VHZ3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1080 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997855.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10612"/>
    <dbReference type="EnsemblBacteria" id="EFK59695">
        <property type="protein sequence ID" value="EFK59695"/>
        <property type="gene ID" value="HMPREF0766_10612"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_862589_0_0_10"/>
    <dbReference type="OrthoDB" id="1452706at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106919" description="DUF1080 domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1080" evidence="2">
        <location>
            <begin position="169"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="339" mass="36894" checksum="839F18A6D35E9071" modified="2010-10-05" version="1">MIKKFMYSALAVASISAGLVSCNPTAKDGSATQDSVAKEEVHNPATQTIPEEYKDLIGRWDLTVDKNGKEAPSWIEIKLSGFNTLVGAYVGDSGSQRPVSHVILKDGKFSFAIPPQWEGGEGDFTIEGQLDAGNLKGTVTTNKNEKFTFTGVKAPYLNRTGEVKWGSPIALFNGKDLTGWKASAPENQWKVIDGVLTSEKAGANLISDQKFEDFKLTAEFRYKEGGNSGIYLRGRYEVQIEDSPKDKHPGALYFGGVYGFIAPNEMVTLGPNEWQKYEITLRGRLVTIVANGKTIISNQEIPGITGGALDSKEGEPGPIYLQGDHAPIEFRNITITPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI40</accession>
    <name>D7VI40_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">uhpA</name>
        <name evidence="5" type="ORF">HMPREF0766_10659</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997950.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10659"/>
    <dbReference type="EnsemblBacteria" id="EFK59742">
        <property type="protein sequence ID" value="EFK59742"/>
        <property type="gene ID" value="HMPREF0766_10659"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_1_10"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="211" mass="23613" checksum="8F79A670CFA7BBA0" modified="2010-10-05" version="1">MFEKTIKIAIVDDHLIVLEGLSRLIESNPEYTIAGTFTHGYDFLTFVKTEPVDIVLLDISLPDISGIDLCLQIKKVAPDAAIIAISNHIERSIILQMLQNGAVGYLLKNVDLHELKNALNEALSGKVTFSSDVKEIIARPHLHDLIELPKLTKREKEILQHIALGKTTTTIADELFLSPLTIETHRKRMMSKFKAKNMAALIKTAMEHNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI50</accession>
    <name>D7VI50_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997970.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10669"/>
    <dbReference type="EnsemblBacteria" id="EFK59752">
        <property type="protein sequence ID" value="EFK59752"/>
        <property type="gene ID" value="HMPREF0766_10669"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZMB2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129762_0_0_10"/>
    <dbReference type="OrthoDB" id="1517289at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106978" evidence="1">
        <location>
            <begin position="21"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="175" mass="18466" checksum="893D7DEBA1D0A27E" modified="2010-10-05" version="1">MKKFLLALVVTGAMVTAAKAQTAAVKVNVILNPIQSISLGEGASNDVVNLEYKTVEDYKNGVSKTVNNQLYVTSIGGGYKIKAKSSVNNPVATTAAEKNIDGSTVTVKIEGKGTTYTNNIRDLVAGKDAYQSTATSGESLNVTYAAAGNNAYVDKVLNKQKTTYTVNVVYEITAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI72</accession>
    <name>D7VI72_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998012.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10691"/>
    <dbReference type="EnsemblBacteria" id="EFK59774">
        <property type="protein sequence ID" value="EFK59774"/>
        <property type="gene ID" value="HMPREF0766_10691"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_870829_0_0_10"/>
    <dbReference type="OrthoDB" id="1722208at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="305" mass="35409" checksum="3196B5F95096ED97" modified="2010-10-05" version="1">MGITKIATKKNIAQRQWTYTNSAREAWSNILDILKKENPQYKILLPAYIGWSPNEGSGIFDSVKNSSLDFDFYNLDRNLKIDFDHFKNKIKETKSCIVLLVHYFGFPDVQYQKIINWLDQNNILYIEDCAHSWLTDLIGGKCGRNGRFAFYSLHKMLPVSGGGIMVDNKPDIDNKSETFQPHFDLGYDLFTIYRKRRENYTYLVEKLKGIPNIDIIHTDLEDGICPQTLPVVIRNYDRNKLYQEMNDFEIGMVSLYHTMIDELKNSTSEAANFTSKHIINFPVHQDIVFGELDNLMVKLKAILNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VII3</accession>
    <name>D7VII3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10802"/>
    <dbReference type="EnsemblBacteria" id="EFK59885">
        <property type="protein sequence ID" value="EFK59885"/>
        <property type="gene ID" value="HMPREF0766_10802"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1950">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120441_2_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37309">
        <property type="entry name" value="PTHR37309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="136" mass="14800" checksum="7DCB8933C8BBFD27" modified="2010-10-05" version="1">MVFGTYFERFYPELLNHFAMKFIISLLLTGVVVAVSAWIIPGVYVAGFGWAIVTGLVIGFVNATVGSILRLFTFPLNWLTLGLVSFIITVLMVLLSDKIMGAKFDVSGFWTAALFAIVVAIVEMILSAILGSSKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VII7</accession>
    <name>D7VII7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_10806</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998238.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10806"/>
    <dbReference type="EnsemblBacteria" id="EFK59889">
        <property type="protein sequence ID" value="EFK59889"/>
        <property type="gene ID" value="HMPREF0766_10806"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_2_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106989" evidence="5">
        <location>
            <begin position="24"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="124"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="406"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1017" mass="113049" checksum="46285A50FB25EF51" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIL5</accession>
    <name>D7VIL5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998294.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10834"/>
    <dbReference type="EnsemblBacteria" id="EFK59917">
        <property type="protein sequence ID" value="EFK59917"/>
        <property type="gene ID" value="HMPREF0766_10834"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017617_1_0_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041700">
        <property type="entry name" value="OMP_b-brl_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14905">
        <property type="entry name" value="OMP_b-brl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107536" description="OMP_b-brl_3 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl_3" evidence="2">
        <location>
            <begin position="371"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="796" mass="90195" checksum="5E08221F24D42AA9" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIP0</accession>
    <name>D7VIP0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cdsA</name>
        <name evidence="2" type="ORF">HMPREF0766_10859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10859"/>
    <dbReference type="EnsemblBacteria" id="EFK59942">
        <property type="protein sequence ID" value="EFK59942"/>
        <property type="gene ID" value="HMPREF0766_10859"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037294_1_1_10"/>
    <dbReference type="OrthoDB" id="1533756at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="242" mass="26579" checksum="D82069213892A826" modified="2010-10-05" version="1">MMFLNLIYIVVLFFGIGALLTVILNKSSNPEQKRSRWIKYILYLLIILITAGCIQAGLMIFLASGLIFAGFVELLLVGMRSNRGVIFSIGSILIYIGIAIGFYRFIVSSTPEELLYIYTIIFTFDGFSQLFGQLFGKRRILPKISPNKTAAGTVGGSIAGYATGLLIIAHAQTVDGFSLILPLLICICAFAGDALASWYKRLCATKDYSRLIPGHGGILDRYDSFIFTGSIFGLVHFGRIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIR2</accession>
    <name>D7VIR2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycine cleavage system P-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">gcvP</name>
        <name evidence="9" type="ORF">HMPREF0766_10881</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GcvP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998394.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10881"/>
    <dbReference type="EnsemblBacteria" id="EFK59964">
        <property type="protein sequence ID" value="EFK59964"/>
        <property type="gene ID" value="HMPREF0766_10881"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_3_2_10"/>
    <dbReference type="OrthoDB" id="70707at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="957" mass="104211" checksum="DE192D4C4BF99745" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIZ0</accession>
    <name>D7VIZ0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998553.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10959"/>
    <dbReference type="EnsemblBacteria" id="EFK60042">
        <property type="protein sequence ID" value="EFK60042"/>
        <property type="gene ID" value="HMPREF0766_10959"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067676_4_0_10"/>
    <dbReference type="OrthoDB" id="1948290at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK60042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="211" mass="24352" checksum="B96FE8222DFD1213" modified="2010-10-05" version="1">MYQSEELLNTYLEHTCDAESALLKRINRETYLRETMPHMLSGHYQGRVLSFLSKMARPGRILEIGTFTGYATLCLAEGLSKDGEIHTIDINAEQEERVQGYFDQSLYKEQIRYHIGDALEVINEISGDFDLIFIDADKKRNLQYYELLVDRVPSGGLIMIDNVLWKGKVLQEDPDNQTKQILGLNEQLAKDQRVDKLILPIRDGLFVLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ05</accession>
    <name>D7VJ05_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK59140">
        <property type="protein sequence ID" value="EFK59140"/>
        <property type="gene ID" value="HMPREF0766_10974"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZCVH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1647440_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="162" mass="18198" checksum="6C8152B05AE842B5" modified="2010-10-05" version="1" fragment="single">MSDFLSINGVSVERDDIRNVLLGEGKVAAIKYVADRTQCSLKDAHMVVTEIEEGVATVKVPVVEQTVREKAVVKYVDGKIQVTYQDNDGVVYENVNPAHPVWMAVKRLMPDNQTLMDMEEFYAQDEPVIKASPFHSYNEEVLGHRKPNFLLIGVIVLLLVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ27</accession>
    <name>D7VJ27_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="9">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">alaS</name>
        <name evidence="11" type="ORF">HMPREF0766_10996</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="9"/>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10996"/>
    <dbReference type="EnsemblBacteria" id="EFK59162">
        <property type="protein sequence ID" value="EFK59162"/>
        <property type="gene ID" value="HMPREF0766_10996"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_1_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="10">
        <location>
            <begin position="23"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="582"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="586"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="686"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="690"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK59162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="893" mass="100042" checksum="CE4763FC88CCDBE7" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ68</accession>
    <name>D7VJ68_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Primosomal protein N'</fullName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">priA</name>
        <name evidence="12" type="ORF">HMPREF0766_11037</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11037"/>
    <dbReference type="EnsemblBacteria" id="EFK58921">
        <property type="protein sequence ID" value="EFK58921"/>
        <property type="gene ID" value="HMPREF0766_11037"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013353_3_1_10"/>
    <dbReference type="OrthoDB" id="1132322at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041236">
        <property type="entry name" value="PriA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040498">
        <property type="entry name" value="PriA_CRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18074">
        <property type="entry name" value="PriA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18319">
        <property type="entry name" value="PriA_CRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00595">
        <property type="entry name" value="priA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="301"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="544"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="558"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK58921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="825" mass="93510" checksum="9E16A73735AFC23D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ77</accession>
    <name>D7VJ77_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transport energizing protein, ExbD/TolR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11046</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000420.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11046"/>
    <dbReference type="EnsemblBacteria" id="EFK58930">
        <property type="protein sequence ID" value="EFK58930"/>
        <property type="gene ID" value="HMPREF0766_11046"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085305_3_4_10"/>
    <dbReference type="OrthoDB" id="1537812at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="136" mass="15245" checksum="B618E5E81B2433ED" modified="2010-10-05" version="1">MNIRNRRNRPSAEVHTAALNDIMFFLMLFFLLASAVSNPQVVKLLLPRSSAGEQSVAKKTMTVSITSDLQYHVDKQIVPYESLEPLIQSRMASGEELTIMLYADSSVPIQNVISVMDVANRLKIKLVLATEPRKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJH8</accession>
    <name>D7VJH8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GIY-YIG catalytic domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000651.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11147"/>
    <dbReference type="EnsemblBacteria" id="EFK59031">
        <property type="protein sequence ID" value="EFK59031"/>
        <property type="gene ID" value="HMPREF0766_11147"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2827">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135650_6_3_10"/>
    <dbReference type="OrthoDB" id="2077602at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="81" mass="9630" checksum="510CD4F0A237E2FD" modified="2010-10-05" version="1">MFTVYVLYSGVYDKIYIGMTSDLPGRLLSHNELGTKGWTIRYRPWELLYTEEYATKSEALKREQELKSYQGRLFIRSLLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJJ4</accession>
    <name>D7VJJ4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartate 1-decarboxylase</fullName>
            <ecNumber evidence="9">4.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aspartate alpha-decarboxylase</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="9 14" type="primary">panD</name>
        <name evidence="14" type="ORF">HMPREF0766_11163</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H(+) + L-aspartate = beta-alanine + CO2</text>
            <dbReference type="Rhea" id="RHEA:19497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="4.1.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="9 10">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooctamer of four alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9 12">Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PanD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.11" evidence="9"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000684.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11163"/>
    <dbReference type="EnsemblBacteria" id="EFK59047">
        <property type="protein sequence ID" value="EFK59047"/>
        <property type="gene ID" value="HMPREF0766_11163"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115305_2_0_10"/>
    <dbReference type="OrthoDB" id="1751990at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004068">
        <property type="term" value="F:aspartate 1-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006523">
        <property type="term" value="P:alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06919">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00446">
        <property type="entry name" value="PanD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003190">
        <property type="entry name" value="Asp_decarbox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21012">
        <property type="entry name" value="PTHR21012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02261">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006246">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00223">
        <property type="entry name" value="panD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5013997728" description="Aspartate 1-decarboxylase beta chain" evidence="9 13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013997729" description="Aspartate 1-decarboxylase alpha chain" evidence="9 13">
        <location>
            <begin position="25"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 11">
        <location>
            <begin position="73"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="9 10">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="9 12">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFK59047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="116" mass="12848" checksum="EEE2E8C7B617903E" modified="2010-10-05" version="1">MIIEVMKSKIHRVRVTQAELNYVGSITIDEDLMDAANIIANEKVQIVNNNNGARLETYVIPGQRGSGTICLNGAAARLVQVGDIVIIISYAQMEMEEARKHIPTLVFPDDNNKLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJT7</accession>
    <name>D7VJT7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11256"/>
    <dbReference type="EnsemblBacteria" id="EFK58539">
        <property type="protein sequence ID" value="EFK58539"/>
        <property type="gene ID" value="HMPREF0766_11256"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006833_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1075" mass="121860" checksum="0CB8098311B46684" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJV2</accession>
    <name>D7VJV2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998648.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11271"/>
    <dbReference type="EnsemblBacteria" id="EFK58554">
        <property type="protein sequence ID" value="EFK58554"/>
        <property type="gene ID" value="HMPREF0766_11271"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1766852_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="147" mass="16968" checksum="F28686E08413E46A" modified="2010-10-05" version="1">MKKNVLFSLIPFILVVSCYSQKYKVSSSINNKVSTETFVKKRLLKLPDSLGGNSITGYAILESKIVTNTSEIVKVEIMKLLVKSKEENKEEVDYYHGIDTVGYRKDYDNMVRFKPFLEESFRSLKEIKNNQFDVRGDTCVFGIKIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK88</accession>
    <name>D7VK88_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, GntR family</fullName>
            <ecNumber evidence="3">2.6.1.39</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.39" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999032.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK58690">
        <property type="protein sequence ID" value="EFK58690"/>
        <property type="gene ID" value="HMPREF0766_11407"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_1_10"/>
    <dbReference type="OrthoDB" id="1320028at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="487" mass="55274" checksum="30E33F70AB978535" modified="2010-10-05" version="1">MFPFESIITIERTHKNPVYLQIAFAISNAIRNGILKPGAALPGSREMAQKLVVHRKTVLAAYEELIAQDYIKAIPRKGIYVSEQLPLLKPKKWNSERMLNAYGYRLEIPGEHMMQPAKKKDHMAILKLIIDDGYPDVRLSPIDTLLKSYRFILTKKNNIEQSKEDNARGSTRLRDQLALLLSETRGINIGKENILITHGAQMSIYIAAHLLINKNTQVIVGDPGYTTATKVFTDMGATVIRVPVDKYGLDVDAIAQICAHQTIHFLYVIPHHHYPTTVTLTTERRMRLLELAKQYDFVIIEDDYDYDYHYDSAPYLPLASANHEGRVIYIGSFSKILAPSIRIGFMIAPGNFIDHAADFRKSIDVGGDMFMQDALASLIQEGELKRYITKAKKAYHQRRDRLYDLLTKKAGSYVSLSLPGGGMAMWIQLDKKIPVRQLHEILLRNGIKIKVLNEELNAFRFGFASLNLTEIEEAIDIIEMAIHKIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK92</accession>
    <name>D7VK92_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Homoserine O-acetyltransferase</fullName>
            <shortName evidence="2">HAT</shortName>
            <ecNumber evidence="2">2.3.1.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Homoserine transacetylase</fullName>
            <shortName evidence="2">HTA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">metX</name>
        <name evidence="2" type="synonym">metXA</name>
        <name evidence="5" type="ORF">HMPREF0766_11411</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13701"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="EC" id="2.3.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.31" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999041.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11411"/>
    <dbReference type="EnsemblBacteria" id="EFK58694">
        <property type="protein sequence ID" value="EFK58694"/>
        <property type="gene ID" value="HMPREF0766_11411"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028760_1_2_10"/>
    <dbReference type="OrthoDB" id="536745at2"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="PTHR32268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="39"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2 3">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="351" mass="39266" checksum="830B81D64390283D" modified="2010-10-05" version="1">MSSKTFKYTEPFVFENGRQIDDLQIAYHTYGKLNADRDNVVWVCHALTANSDVFDWWKGLFGENDLFNPRDYFIVCANVLGSHYGSSGPLSVNPQTDQPYYLSFPQFTVRDIVQANQLLADHLEIQKIDILIGGSLGGQQALEWAASAQIDISHLIVIATNAVHSPWGIAYNESQRLAITADRTFYANKPDGGSKGLKAARSLALLSYRSYDTYAATQAESDIEKTEQYKASSYQSYQGDKLVNRFNAYSYWFLSKAMDSHHLGRGRVSATQTLQQLKQKTLVIGITTDVLFPPAEQQFIAQHITGAEYYQLDSLYGHDGFLIETKTLSQIISGFLAAQFAEDKSIELTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKA6</accession>
    <name>D7VKA6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminodeoxyfutalosine synthase</fullName>
            <shortName evidence="6">AFL synthase</shortName>
            <shortName evidence="6">Aminofutalosine synthase</shortName>
            <ecNumber evidence="6">2.5.1.120</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Menaquinone biosynthetic enzyme MqnE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mqnE</name>
        <name evidence="8" type="ORF">HMPREF0766_11425</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine = 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:33075"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64286"/>
            <dbReference type="ChEBI" id="CHEBI:76981"/>
            <dbReference type="EC" id="2.5.1.120"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. MqnE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.120" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999076.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11425"/>
    <dbReference type="EnsemblBacteria" id="EFK58708">
        <property type="protein sequence ID" value="EFK58708"/>
        <property type="gene ID" value="HMPREF0766_11425"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040406_1_0_10"/>
    <dbReference type="OrthoDB" id="940969at2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102573">
        <property type="term" value="F:aminodeoxyfutalosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00993">
        <property type="entry name" value="MqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022432">
        <property type="entry name" value="MqnE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03700">
        <property type="entry name" value="mena_SCO4494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="66"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="400" mass="46660" checksum="A098E2CA75322887" modified="2010-10-05" version="1">MEARHKIDFLINDSRLDPELRRIAEKVVAGERITFDEGVLLYEKGELSYLGVLANYIREKRHGDITYFNRNFHIEPTNVCVYDCKFCSYSRMIKQREEGWEMDVDAMIDIVKKYDDEPVTEVHITGGVVPKQNLEFYADFFRKCKAHRPELHIKALTPVEYYYIFKKAKLSHFDGMKYLKEAGLDSMPGGGAEIFHPEIREQIAHDKCTAEQWLDIHEQAHLLGMNTNATMLYGHIEKFWHRVDHMERLRQLQDKTGGFQTFIPLKFRNKENQMSDVDEVSVIEDLRNYAVARIYMDNFPHIKAYWAMISRDTAQMSLSFGVDDIDGTLDDTTKIYSMAGAEEQTPAMSTQQLVELIKNVGRHPIERDTLYHVVTDYKDHVFDDESAKKKNYYALPVLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKC6</accession>
    <name>D7VKC6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK58728">
        <property type="protein sequence ID" value="EFK58728"/>
        <property type="gene ID" value="HMPREF0766_11445"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3173345_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="47" mass="5453" checksum="19C8A463EA7DFF52" modified="2010-10-05" version="1">MKAIHNNKLQPQQYNKVVVNIIKSKNESNSQQEGKEVHLDVSCCKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKD2</accession>
    <name>D7VKD2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphoribosylformylglycinamidine synthase</fullName>
            <shortName evidence="10">FGAM synthase</shortName>
            <shortName evidence="10">FGAMS</shortName>
            <ecNumber evidence="10">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Formylglycinamide ribonucleotide amidotransferase</fullName>
            <shortName evidence="10">FGAR amidotransferase</shortName>
            <shortName evidence="10">FGAR-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">purL</name>
        <name evidence="14" type="ORF">HMPREF0766_11451</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="10"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999152.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11451"/>
    <dbReference type="EnsemblBacteria" id="EFK58734">
        <property type="protein sequence ID" value="EFK58734"/>
        <property type="gene ID" value="HMPREF0766_11451"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0046">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0047">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001031_0_2_10"/>
    <dbReference type="OrthoDB" id="26038at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="SSF82697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 10 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_N" evidence="13">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT_linker" evidence="12">
        <location>
            <begin position="122"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="11">
        <location>
            <begin position="380"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="11">
        <location>
            <begin position="782"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="1070"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="1183"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="1185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="664"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="668"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="826"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFK58734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1222" mass="133970" checksum="CBF69E7207CA15ED" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKE6</accession>
    <name>D7VKE6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11465"/>
    <dbReference type="EnsemblBacteria" id="EFK58748">
        <property type="protein sequence ID" value="EFK58748"/>
        <property type="gene ID" value="HMPREF0766_11465"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_1_4_10"/>
    <dbReference type="OrthoDB" id="233664at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="34"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="281"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="528" mass="59966" checksum="B082E20392C46C68" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKH0</accession>
    <name>D7VKH0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11489</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999253.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11489"/>
    <dbReference type="EnsemblBacteria" id="EFK58772">
        <property type="protein sequence ID" value="EFK58772"/>
        <property type="gene ID" value="HMPREF0766_11489"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00965">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="STN" evidence="6">
        <location>
            <begin position="95"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="937"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1161" mass="131449" checksum="09C0DCFE4E8A1086" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKI7</accession>
    <name>D7VKI7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative DNA modification/repair radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_11506</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999304.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11506"/>
    <dbReference type="EnsemblBacteria" id="EFK58789">
        <property type="protein sequence ID" value="EFK58789"/>
        <property type="gene ID" value="HMPREF0766_11506"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033784_0_0_10"/>
    <dbReference type="OrthoDB" id="940969at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023874">
        <property type="entry name" value="DNA_rSAM_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21180:SF9">
        <property type="entry name" value="PTHR21180:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01102">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03916">
        <property type="entry name" value="rSAM_link_UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="49"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="417" mass="47557" checksum="3B3A78541D94BE46" modified="2010-10-05" version="1">MSDRIKQKLEILADAAKYDVSCSSSGSNRKNTKKGLGDTGAGICHTYTEDGRCVSLLKILLTNHCIFDCAYCVSRSSNDIERAAFTVQEVVDLTINFYRRNYIEGLFLSSGIFKNADYTMERLTKIAKKLRQEHNFNGYIHLKTIPGASDELMFEAGLYADRLSVNLEIPTEQGLKLLAPEKNRADMDKPMGYLKNEIIRTKEEKKIIRAAPKFVPAGQSTQMIIGASGESDLHIMKTADHYYQQYNLKRVYYSGYVPVSNDKRLPGLGSEVPIMRENRLYQTDWLLRFYGFKREDILNETHPHLDLDIDPKLGWALRHMEQFPVDINRASYEMIMRVPGIGVTSAKKIVAARRFGALRLENLQKIGVSVNKVKYFISCQGFVPIRSDKPAEVIKHYILTSGKSKYEKMFNQQLSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKN6</accession>
    <name>D7VKN6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Demethylmenaquinone methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.163</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">menG</name>
        <name evidence="5" type="ORF">HMPREF0766_11555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.163"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999408.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11555"/>
    <dbReference type="EnsemblBacteria" id="EFK58838">
        <property type="protein sequence ID" value="EFK58838"/>
        <property type="gene ID" value="HMPREF0766_11555"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_0_0_10"/>
    <dbReference type="OrthoDB" id="1431378at2"/>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="119"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="246" mass="27661" checksum="5C4EB4275172D4F7" modified="2010-10-05" version="1">MTNESSTLKPYKNAEGDKKTQVADMFNNISKTYDFLNHFMSLGIDIIWRKKAIRSLRSIQPQIMLDVATGTGDFALESIKILNPKKIIGVDISEGMLQVAQEKIKSKGLQQQFEVQLGDSEKLLFEDNTFDAVTVAFGVRNFENLEQGLADICRVLKPGGKAVILEFSNPKSFPIKQLYNFYFHNVTPLIGKLFSKDNSAYSYLPESVAKFPDGNRFATIMKEVGFSETIIRPQTFGVCTIYVSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKP2</accession>
    <name>D7VKP2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999421.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11561"/>
    <dbReference type="EnsemblBacteria" id="EFK58844">
        <property type="protein sequence ID" value="EFK58844"/>
        <property type="gene ID" value="HMPREF0766_11561"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067500_1_0_10"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045746">
        <property type="entry name" value="ACT14924-like_Acyltransf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19576">
        <property type="entry name" value="Acyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="85"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="277" mass="32348" checksum="1B5DF5844BEC78BF" modified="2010-10-05" version="1">MQQEEHKKFIEVREVIRKKSPKLAKWIPSPFIRYLERVIHENEINYIMNKFEDRYGLDFVDDLLEELGVEVVLEGEENIPLEDSVIFASNHPLGGLDGVAFMHAVGRYRRDVKFLVNDILLNIKNLQPLFIPVNKLGTQGKNGIEMIERAYAGDDALLVFPAGLVSRKQNGKIMDLEWKKSFINKAKKYKKDIIPVYIEGKNSNFFYNFALLRQKLGLKVNLEMLYLPDEMFAQRNHRVTIKIGKRIPYTHFDTSNSEKVWAEEVKQLVYKMAELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKP3</accession>
    <name>D7VKP3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999423.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11562"/>
    <dbReference type="EnsemblBacteria" id="EFK58845">
        <property type="protein sequence ID" value="EFK58845"/>
        <property type="gene ID" value="HMPREF0766_11562"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102952_0_0_10"/>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="67"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="220" mass="24924" checksum="E7D9C69E110D524D" modified="2010-10-05" version="1">MYIGEILSQKFCEVSPSDTVQKGLDKIGEFHLSHLPVVSNKEYIGMINEDELLNHEDETDIIKNLKLNLAPLYLYEYQHIYDAMLYLTNYKIELLPILNKDNRYIGIITAQDVLQALNSLQSNNETGAIIVLEIGAKDNALSHIAHIIESDNASILSTAVKTLPDSSKLELTIKVNKTNISSLVATLWRFDYVVKATFNDGNGENDMQQRYDLLMNYLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKT0</accession>
    <name>D7VKT0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">rho</name>
        <name evidence="12" type="ORF">HMPREF0766_11599</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999484.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11599"/>
    <dbReference type="EnsemblBacteria" id="EFK58882">
        <property type="protein sequence ID" value="EFK58882"/>
        <property type="gene ID" value="HMPREF0766_11599"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016377_4_1_10"/>
    <dbReference type="OrthoDB" id="1619125at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01128">
        <property type="entry name" value="rho_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041703">
        <property type="entry name" value="Rho_factor_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="11">
        <location>
            <begin position="128"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="41"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="59"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="246"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="258"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK58882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="495" mass="54944" checksum="337DD9615EBDE8D6" modified="2010-10-05" version="1">MDVNELNAKLVSELREIAKAIGIEDADKLRKQELIDRIIQTGDDNNAEAASSEPSSIQDDASERPRRRTRTVKAEPVTIRRRSDDDVETHDHPEKTTEATEDIKVAATPKAAPVKTEAAVVPTDFDNVIVNEGVLEIMPDGYGFLRSSDYNYLTSPDDIYVSQSQIKLFGLKTGDTVRGSIRPPKEGEKYFPLVRVEAINGQNPAEVRDRVPFDYLTPLFPTERLNLNMGANNYSTRIMDLFTPIGKGQRGLIVAQPKTGKTNLLKEVANAIAKNHPEVYLIILLIDERPEEVTDMARSVRAEVVASTFDEPADRHVKIANIVLEKAKRMVECGHDVVILLDSITRLARAYNTVAPASGKILSGGVDANALHKPKRFFGAARNIENGGSLTILATALTETGSKMDEVIFEEFKGTGNMELQLDRKLANKRVFPAIDLTASSTRRDDLLSDKDTLQRVWVLRNHLADMNSNEAMEFLLAQMRGTMSNEEFLISMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL09</accession>
    <name>D7VL09_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999703.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11678"/>
    <dbReference type="EnsemblBacteria" id="EFK58282">
        <property type="protein sequence ID" value="EFK58282"/>
        <property type="gene ID" value="HMPREF0766_11678"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036524_2_2_10"/>
    <dbReference type="OrthoDB" id="1798994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="24"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="215" mass="24746" checksum="9B2BCF57B1F6FACD" modified="2010-10-05" version="1">MNNIIEKTVAFVKKSLEQAESGHDWWHIQRVWNNTRMILQHEEADELICELTALLHDIADSKFHNGDETIGPRIAGEFLSSEGVDPQIIEQVQAIILNMSFKASLGERNFHSKELEIVQDADRLDAIGAIGIARAFTYGGFKNREIHNPNIPVMENMDKEAYKKTTAPTINHFYEKLLLLKDKMNTPTAKKMAEGRHQYMEQFLEQFYAEWEGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL21</accession>
    <name>D7VL21_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4180 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11690"/>
    <dbReference type="EnsemblBacteria" id="EFK58294">
        <property type="protein sequence ID" value="EFK58294"/>
        <property type="gene ID" value="HMPREF0766_11690"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3012016_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025438">
        <property type="entry name" value="DUF4180"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13788">
        <property type="entry name" value="DUF4180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4180" evidence="1">
        <location>
            <begin position="9"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="56" mass="6360" checksum="EC4779987CBD5D03" modified="2010-10-05" version="1">MKIEEHNLNNIKIAEILSAARIINTSQDGLDLLGNLYYQGFDKIVIHKGNITPDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL42</accession>
    <name>D7VL42_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999755.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11711"/>
    <dbReference type="EnsemblBacteria" id="EFK58315">
        <property type="protein sequence ID" value="EFK58315"/>
        <property type="gene ID" value="HMPREF0766_11711"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105851_1_1_10"/>
    <dbReference type="OrthoDB" id="1817663at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35145">
        <property type="entry name" value="PTHR35145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="119" mass="13705" checksum="5D3E62E1F45CEDC6" modified="2010-10-05" version="1">MNIEQLREYCICKKGATEELPFGPDTLVFKVAGKVFLLVGLDQIDKLSFNVKCDPEYAVELREKYESTVLPGYHMNKKHWNTVFANQVLSDKELFVLIDHSYDLIVKALPLKIRETLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLJ8</accession>
    <name>D7VLJ8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4'-phosphopantetheinyl transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11868"/>
    <dbReference type="EnsemblBacteria" id="EFK58471">
        <property type="protein sequence ID" value="EFK58471"/>
        <property type="gene ID" value="HMPREF0766_11868"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104083_3_0_10"/>
    <dbReference type="OrthoDB" id="1542506at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="108"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="212" mass="24681" checksum="3C0DE18595DCE282" modified="2010-10-05" version="1">MALAYLRELDEHTKLAIWKIEESAEELLAKLQLDTRERALLDSFGKGKRSLHWMTTRVLLRYLLQTDQYIDCPSDENGKPYLTNFPYKISLTHSYDYAAVLISAKGEVGIDLEIVKDKVIRIKHKFLKPEELAFIQGEQSTEQLYACWCAKEAIYKLQGNKGVSFLNNMTILPFEYQAQGVLKLQLEVNQIRKTYNVYYEKFGEYMLGYAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLR5</accession>
    <name>D7VLR5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000325.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11935"/>
    <dbReference type="EnsemblBacteria" id="EFK58538">
        <property type="protein sequence ID" value="EFK58538"/>
        <property type="gene ID" value="HMPREF0766_11935"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5580">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049046_5_0_10"/>
    <dbReference type="OrthoDB" id="1914312at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039981">
        <property type="entry name" value="AHSA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="PTHR13009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="127" mass="14540" checksum="4A56BEECCA7D2E6F" modified="2010-10-05" version="1">MKDFKKYFIIPATPDEVYLALTTEITARLWTGDEASIDPVEGGEFSMWDGAIIGKFISLEPGKKIVQQWYFGEQEEPSIVTLKLHEHKKGTSLEVNHLHIPDEAFDDIAEGWTNPYMASLIEFYEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLR7</accession>
    <name>D7VLR7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000007">
        <property type="protein sequence ID" value="EFK58219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11937"/>
    <dbReference type="EnsemblBacteria" id="EFK58219">
        <property type="protein sequence ID" value="EFK58219"/>
        <property type="gene ID" value="HMPREF0766_11937"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZC53">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110670_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="218" mass="25426" checksum="9E19E107D2DD83A3" modified="2010-10-05" version="1">MSGKILHLTQIKEIDMYNLLQHIVDNDVLHAKWLNTLSFMENAGARKISACEHTTDVNLIQLKHAAEEHRHAYYLKKQIAKTNIHTCKTYRTEELIASACTRNYLQQLDIYACRYLKNTFGLRNNELKYAAYLFVTYAIEVRADDLYPIYQQVLDASKSKVMVKSIILEEEGHLEEMIHQLEGFASDWEVHAKKIQDLEQQLFEEWVAAIALDVKHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLX1</accession>
    <name>D7VLX1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK57976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001069.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11968"/>
    <dbReference type="EnsemblBacteria" id="EFK57976">
        <property type="protein sequence ID" value="EFK57976"/>
        <property type="gene ID" value="HMPREF0766_11968"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_5_3_10"/>
    <dbReference type="OrthoDB" id="1878940at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="213" mass="24225" checksum="9CEEE09ECBDF7EBA" modified="2010-10-05" version="1">MKEAKQKHWSIVEYLHETVTNTNIHIKGTKSYYSSAWTGSFEESVVRYLYGDAYSLKTWKPQWKIDQLYIGNYVCIGAEVIILMGGNNTHRSDWFSLYPFAETLEESYKTKGDTHIDDGAWLGIRSVLMPGIRIGEGAIVAAGAIVTKDVAPYSIVGGNPAKLIGYRFPEETIAKLLEMQLYSWPEEKFETLKSYICANDIDQLVKAEKEYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLY4</accession>
    <name>D7VLY4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase, class I/II</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aspC</name>
        <name evidence="2" type="ORF">HMPREF0766_11981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK57989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001108.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11981"/>
    <dbReference type="EnsemblBacteria" id="EFK57989">
        <property type="protein sequence ID" value="EFK57989"/>
        <property type="gene ID" value="HMPREF0766_11981"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_10"/>
    <dbReference type="OrthoDB" id="554560at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="35"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="399" mass="44128" checksum="0A6C02F0938756DD" modified="2010-10-05" version="1">MPAISSKGIHMPASPIRKLTPFADKAKKEGKKIYHLNIGQPDIETPQIMLDAIKNIDFKVWAYTPSEGTAAYRNKLVEYYNKLDYNVTASDILVTNGGSEAITIAMQACLNPGEEVIIPEPFYANYNGFACAADIVVKPIMSYIDNGFALPPIAEFEKLITDKTKAIAICNPNNPTGYLYSREELEALRDLCLKYDLFLFSDEAYREFCYDGKAFISPMHLEGLEQHVVIFDTVSKRYSACGARLGCLVTKNKELYNVALKFAQARLSPPAVAQIAATAAVDTPDSYFEAVSKEYTARRDTLVQGLNSIEGVFCPNPGGAFYVVAKLPIDNADKFCQWMLESFSYENQTVMMAPATGFYSTPGAGLNEVRMAYVLNQSDLKNALVCLEKALAEYPGRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLZ6</accession>
    <name>D7VLZ6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001148.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11993"/>
    <dbReference type="EnsemblBacteria" id="EFK58001">
        <property type="protein sequence ID" value="EFK58001"/>
        <property type="gene ID" value="HMPREF0766_11993"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1626024_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="163" mass="19384" checksum="88B5AA20D65B5B1E" modified="2010-10-05" version="1">MKLDGSVELENILEADHVVSHYYALVDRKQKSVLKFKSFIDSNPISMNYDSLYMNLFTFNGQIILPQNNAQIKKYTLGKYYIKEESDVKEHKSYCQKLFFSDDIPSTNFSFSEILEKEEMKKLVKIHVFEKENDREQTVKWEIKKLNEEVPSEIIEFMKLHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM00</accession>
    <name>D7VM00_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001159.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11997"/>
    <dbReference type="EnsemblBacteria" id="EFK58005">
        <property type="protein sequence ID" value="EFK58005"/>
        <property type="gene ID" value="HMPREF0766_11997"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_0_2_10"/>
    <dbReference type="OrthoDB" id="678616at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1" evidence="2">
        <location>
            <begin position="94"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="552" mass="63780" checksum="F9168498534E09BD" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM45</accession>
    <name>D7VM45_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">amt</name>
        <name evidence="8" type="ORF">HMPREF0766_12042</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001282.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12042"/>
    <dbReference type="EnsemblBacteria" id="EFK58050">
        <property type="protein sequence ID" value="EFK58050"/>
        <property type="gene ID" value="HMPREF0766_12042"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_10"/>
    <dbReference type="OrthoDB" id="562287at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="7">
        <location>
            <begin position="41"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="437" mass="46577" checksum="EBD5AAA3CC8BE0CA" modified="2010-10-05" version="1">MKSKKSVFPLIFMVGVLILALIFPSVPVSGGDFEYSGSDTAWMLTSTALVLIMTPGLAYFYGGMVKKKNVISTMLQSFICMAVVAVIWVVFGFSLVFGTSIGGIIGDPRTYFMFEHVIGGKPWPGAPTIPFTLFAMYQLKFAIITPALITGAVAERIRFTSYILFICLFFIFIYAPLAHATWHPDGVLFKLGVLDFAGGTVVHMSAGLTALAAAIYLKQGKDFHAHNPARITYVMLGTGMLWFGWFGFNAGSAFGANALAATALATTSAASGAAALMWIFFDAARGIKPSAMGTCIGAVVGLVAITPAAGFVTVPHSLIIGAVAALISRMVVDWRTKSRVDDTLDVFPCHGLGGMVGMLLTGIFATKAINGAVEHDGLFFGETTLFVAHVIGLVGATLFTLILAFVLLKLTDLISPLRVSEEEEEIGLDLSQHNEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM50</accession>
    <name>D7VM50_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OmpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_12047</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001299.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12047"/>
    <dbReference type="EnsemblBacteria" id="EFK58055">
        <property type="protein sequence ID" value="EFK58055"/>
        <property type="gene ID" value="HMPREF0766_12047"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016890_9_1_10"/>
    <dbReference type="OrthoDB" id="2018797at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107324" evidence="3">
        <location>
            <begin position="25"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="56"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="173" mass="19131" checksum="FE4DC976D3109F0A" modified="2010-10-05" version="1">MKQLNIFTLILFCAVTLFSCKQQALTVNPGAVLSKDGTDDGLKNVKEEFKDASRTEEGIKFSLSSDFLFPTNSSYLTDKSKGELSKLAKLLKDNSKTKIRVDGHTDATGTPEYNLWLSDKRAVSVKKFLVDSGISESRITTKGIGQAKPVADNKTPEGRQMNRRVEVVLLNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMB1</accession>
    <name>D7VMB1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_12108</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001417.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12108"/>
    <dbReference type="EnsemblBacteria" id="EFK58116">
        <property type="protein sequence ID" value="EFK58116"/>
        <property type="gene ID" value="HMPREF0766_12108"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041771_0_0_10"/>
    <dbReference type="OrthoDB" id="944044at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="354" mass="39442" checksum="9589DDCE41823F06" modified="2010-10-05" version="1">MKYKQIHNNSINQIMLIIIIILICILIFTNLSYYLPGFLGAVTLYILFRNAYFKMTEQRKWNKSLVSLLMVLLTVVFIVFPTWGIINYITPEMTNLIGDKNDIIKNFNSIKDYIATVPLLKNVDLSEEALLNILQKLTRYLPSILNSIAEVGVNLLVSLFVLYFMLVHSKRMESTIYHAIPFSPQSKNELWTEVNMMVRSNAIGIPILALCQGFVAMVGYWFLGVENPILWGGMTAVSTIIPVLGTMTVYVPLSIFLFANGEIGNGIGLLLYGFIVIGGIDNVLRFTILKKLGDVPPLITVFGVLLGLKLFGMLGVIFGPLILSSVGVLLKVYSNEYGRSNSGIPDASEDKTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMG5</accession>
    <name>D7VMG5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PKD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12162"/>
    <dbReference type="EnsemblBacteria" id="EFK58170">
        <property type="protein sequence ID" value="EFK58170"/>
        <property type="gene ID" value="HMPREF0766_12162"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_926961_0_0_10"/>
    <dbReference type="OrthoDB" id="1325780at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010221">
        <property type="entry name" value="VCBS_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01965">
        <property type="entry name" value="VCBS_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="148"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="307" mass="34329" checksum="2D90219D0A31EEEC" modified="2010-10-05" version="1">MTREESSDDKFNIKSYLIISAVGAVLLVSLTIFVMKIFMEPEKKIRAKVFNQDMTLNQDLIYIDNTAGAQKWHWDFGNGDVSTQQDGKYRYKSAGTYVVRLVVNDNLHEQFFVTVKDSVAKVVDSTLQISGPSAGTILKEVRMEVDGPGEIYQWQFGESGKVDVIGKVALYTYSKPGRYRVKVKSDKTLSYTYHTLVIDGAKTDSLDSLAAENQVQKVAIDDLKAQLQAIADGGDFNVRYSYILNKFFCKNERTGVTIKSGGAIKQQDIYSYCIGLTFGGGVKIDNILLMRVPNSNCYQSLIVTQHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMK8</accession>
    <name>D7VMK8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992652.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12228"/>
    <dbReference type="EnsemblBacteria" id="EFK57155">
        <property type="protein sequence ID" value="EFK57155"/>
        <property type="gene ID" value="HMPREF0766_12228"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032YM4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165468_0_0_10"/>
    <dbReference type="OrthoDB" id="1990707at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="96" mass="11253" checksum="E0FA53F93EA36D46" modified="2010-10-05" version="1">MKRSTFDASLLHPEPPADFSVHLQSLWYDAKGDWQTAHDLIDQLHDTVSAHIHAYLHRKEGDQWNANYWYNRAKQPVFSSSLSAEWEHLFDLYGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VML0</accession>
    <name>D7VML0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dipeptidyl-peptidase</fullName>
            <ecNumber evidence="4">3.4.14.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_12230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the removal of dipeptides from the N-terminus of oligopeptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase S46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.-" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992658.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12230"/>
    <dbReference type="MEROPS" id="S46.002"/>
    <dbReference type="EnsemblBacteria" id="EFK57157">
        <property type="protein sequence ID" value="EFK57157"/>
        <property type="gene ID" value="HMPREF0766_12230"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013776_0_0_10"/>
    <dbReference type="OrthoDB" id="99817at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070009">
        <property type="term" value="F:serine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019500">
        <property type="entry name" value="Pep_S46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38469">
        <property type="entry name" value="PTHR38469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10459">
        <property type="entry name" value="Peptidase_S46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023096676" description="Dipeptidyl-peptidase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="712" mass="79688" checksum="E08480A1770A3DFB" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMM6</accession>
    <name>D7VMM6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative neutral zinc metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992692.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12246"/>
    <dbReference type="EnsemblBacteria" id="EFK57173">
        <property type="protein sequence ID" value="EFK57173"/>
        <property type="gene ID" value="HMPREF0766_12246"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084406_0_0_10"/>
    <dbReference type="OrthoDB" id="1656873at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007395">
        <property type="entry name" value="Zn_peptidase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36434">
        <property type="entry name" value="PTHR36434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04298">
        <property type="entry name" value="Zn_peptidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="230" mass="25147" checksum="12A55D729C094634" modified="2010-10-05" version="1">MYIILFVGIMIVSFVVQWRFKNKFKQYSETPLSSGLSGKEIAQKMLNDNGIYDVQVISVDGQLTDHYNPQNKTVNLSPEVYEGRSVAAAAVAAHECGHAVQHATAYSWLQFRSAMVPVVGFASKLTSWILMAGVIMFAISKGGNYWLLAIGVGALAITTVFSFITLPVEFDASNRALAWLNTAGITHSREEHDGAKDALKWAAMTYVVAALSALVTLLYYASILMGGRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMU6</accession>
    <name>D7VMU6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992809.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12316"/>
    <dbReference type="EnsemblBacteria" id="EFK57243">
        <property type="protein sequence ID" value="EFK57243"/>
        <property type="gene ID" value="HMPREF0766_12316"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032Y8A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069060_2_0_10"/>
    <dbReference type="OrthoDB" id="1752332at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025510">
        <property type="entry name" value="DUF4397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14344">
        <property type="entry name" value="DUF4397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107357" description="DUF4397 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4397" evidence="2">
        <location>
            <begin position="39"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="234" mass="25883" checksum="42746B4B609589AF" modified="2010-10-05" version="1">MNSVKFLLGSFLLCLFLFASCSLDNDDYGYGELSGTGAINAVPTAIKLDIGLDQHKLNLSNESFDFGDYLPYRNAFPGNRLVRVFDRDSIGKGALVSKQVAFAPGKIYSLFVVGDTKLDVVSYEDKSDIPAKGTANVRFINLSPDAPALNLGSEGSDTLLVKNKSFKEASAYLTLQTGKKYKLFITSNINRELVSFEFEPKDRSIYTIWSNGLINATPAKEKFKFGYKIIQHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMV5</accession>
    <name>D7VMV5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_12325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992827.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12325"/>
    <dbReference type="EnsemblBacteria" id="EFK57252">
        <property type="protein sequence ID" value="EFK57252"/>
        <property type="gene ID" value="HMPREF0766_12325"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_10"/>
    <dbReference type="OrthoDB" id="1058434at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030296">
        <property type="entry name" value="MlaF/Mkl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023:SF6">
        <property type="entry name" value="PTHR43023:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="254" mass="28637" checksum="4B11828F07013CB8" modified="2010-10-05" version="1">MIEIQNIHKAFGEKEVLKGIDAIFEPGKVSLIIGGSGSGKSTLLKCIVGLHNPEQGRVFFDKQEFTKMSFEERVPIRKEIGMLFQNSALFDSMTVEQNLMFSLDMFTEMSKSEKMDRANFCLERVNLKGTNKLFPAELSGGMKKRVGIARAISMGPKYLFCDEPNSGLDPETSILIDELIQDLTQEYKCTTVVVTHDMNSVMGIGEYILYLYKGEKFWEGTNQDILQSDVKELNDFVFASPLMQAARKTMKHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMV9</accession>
    <name>D7VMV9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gyrB</name>
        <name evidence="6" type="ORF">HMPREF0766_12329</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992834.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12329"/>
    <dbReference type="EnsemblBacteria" id="EFK57256">
        <property type="protein sequence ID" value="EFK57256"/>
        <property type="gene ID" value="HMPREF0766_12329"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006146_1_1_10"/>
    <dbReference type="OrthoDB" id="205481at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Toprim" evidence="5">
        <location>
            <begin position="402"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK57256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="617" mass="69853" checksum="3434D58AE6B42421" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMX1</accession>
    <name>D7VMX1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992848.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12341"/>
    <dbReference type="EnsemblBacteria" id="EFK57268">
        <property type="protein sequence ID" value="EFK57268"/>
        <property type="gene ID" value="HMPREF0766_12341"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066193_1_0_10"/>
    <dbReference type="OrthoDB" id="1757088at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="139"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="247" mass="29605" checksum="BF91B07B5BA073F3" modified="2010-10-05" version="1">MKYREIEPNGFLSGFVKCFWYYETKDKEVFHTILPDGYFDLIAEFENQILTKVKLTGIWTKPKHIQIYKNTTFFAIRFKLPAIEYLFRKELKSILDTTADLPFSFWNIHKYQYDEFENFVFGIISHLETSLKHVHRIDSRKLKLFEIIYQQKTKTVAEISDEIIWSSRQINRYFQSKYGIPLKEFLNIVRCNTAYPEISNGNLNPNSDYFDQAHFIKEIKRYTGVTPKELNQNKNDRFLQLSKEVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN81</accession>
    <name>D7VN81_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 14">Catalase</fullName>
            <ecNumber evidence="3 10 14">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">katE</name>
        <name evidence="16" type="ORF">HMPREF0766_12451</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the catalase family. HPII subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 14"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992995.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12451"/>
    <dbReference type="EnsemblBacteria" id="EFK57378">
        <property type="protein sequence ID" value="EFK57378"/>
        <property type="gene ID" value="HMPREF0766_12451"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_3_0_10"/>
    <dbReference type="OrthoDB" id="1584770at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="PTHR42821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 14" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 14" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="15">
        <location>
            <begin position="26"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFK57378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="707" mass="79623" checksum="8FC3701F5796DE1C" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN93</accession>
    <name>D7VN93_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57390">
        <property type="protein sequence ID" value="EFK57390"/>
        <property type="gene ID" value="HMPREF0766_12463"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3205428_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="45" mass="5143" checksum="1DB76A78A76CE9E9" modified="2010-10-05" version="1">MLLGNLYATSDIPRAVRHYQLALELSKSANEKEMIEKQIKNLSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNJ0</accession>
    <name>D7VNJ0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12560"/>
    <dbReference type="EnsemblBacteria" id="EFK57487">
        <property type="protein sequence ID" value="EFK57487"/>
        <property type="gene ID" value="HMPREF0766_12560"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3296704_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="40" mass="4593" checksum="5982B696BC4C9FFA" modified="2010-10-05" version="1">MSVMKIISIKNGNETKQHLLSLPNKSEKLNQISITKNQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNJ4</accession>
    <name>D7VNJ4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993145.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12564"/>
    <dbReference type="EnsemblBacteria" id="EFK57491">
        <property type="protein sequence ID" value="EFK57491"/>
        <property type="gene ID" value="HMPREF0766_12564"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032W8A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132635_0_0_10"/>
    <dbReference type="OrthoDB" id="1821887at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="112" mass="12961" checksum="ACBF5C0F59EDB4A0" modified="2010-10-05" version="1">METNAIAIKFVSHEVPELETLKTSKVYQLREKLNKGEKLSRAEKNWIAEAVNRNAFFNGAVPLMGYRFGFDDILKTYVVKQYDSWQEYSAPDKTSLRSIIYGRIDQIAEISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNM4</accession>
    <name>D7VNM4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12594"/>
    <dbReference type="EnsemblBacteria" id="EFK57521">
        <property type="protein sequence ID" value="EFK57521"/>
        <property type="gene ID" value="HMPREF0766_12594"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032DVY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151876_1_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107467" evidence="1">
        <location>
            <begin position="23"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="103" mass="11395" checksum="C3CC7680127A3E7A" modified="2010-10-05" version="1">MKSLSYILALMVLVLSTLPSFMEDKCFDLVNQTTNSQEQDSDDCGMECCSPFSKCNTCTGFVITSFYALTSNYVQQPKKKLGVITASAVSDFLSSIWQPPKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNY3</accession>
    <name>D7VNY3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TonB-dependent siderophore receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0766_12703</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993353.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12703"/>
    <dbReference type="EnsemblBacteria" id="EFK57630">
        <property type="protein sequence ID" value="EFK57630"/>
        <property type="gene ID" value="HMPREF0766_12703"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_9_4_10"/>
    <dbReference type="OrthoDB" id="169533at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107176" evidence="7">
        <location>
            <begin position="25"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="9">
        <location>
            <begin position="139"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="8">
        <location>
            <begin position="314"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK57630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="811" mass="92037" checksum="BDABC7D2C8E2C0EF" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNZ1</accession>
    <name>D7VNZ1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12711</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12711"/>
    <dbReference type="EnsemblBacteria" id="EFK57638">
        <property type="protein sequence ID" value="EFK57638"/>
        <property type="gene ID" value="HMPREF0766_12711"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_1_0_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="3">
        <location>
            <begin position="230"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="2">
        <location>
            <begin position="551"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1168" mass="129920" checksum="AEA34529ED678892" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP41</accession>
    <name>D7VP41_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux transporter, outer membrane factor lipoprotein, NodT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993455.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12761"/>
    <dbReference type="EnsemblBacteria" id="EFK57688">
        <property type="protein sequence ID" value="EFK57688"/>
        <property type="gene ID" value="HMPREF0766_12761"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_13_3_10"/>
    <dbReference type="OrthoDB" id="1619477at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="470" mass="52086" checksum="D8BA1632DE688A10" modified="2010-10-05" version="1">MRSIINHIAMCIGTAVLLSSCAVGKPYSRPDLATPENYREQVQVTGDTVLLPWKTFFKDPDLVILIEQALEKNKDISVAMLNLQQLDLSYKQAKRGLLPTLNLAVGASRVYQSRNSLNGSLSEQFTGEKYMDDFSATLTASWEADIWGKVRMQKEAARANYLMQQENLTALKTRIIVQVAQAYYNLITLDEQLKIAANNIKLSDETLQMIRLQFQSAQVNSLGVEQAEAQKKTAELLVPLAKQNIAIQENALSILCGAYPGRIDCSAGLETYSFEENFPVGVPALLLSRRPDLKVAEYAVVVANANVGLNKVAMYPSISLTPSVGANSFKFNNWFDLPGSLVKNIAGNITQPIFQKKELQTNYEQAKIEQQKTAEQFRQSVMNAVAEVSDAMAKTQYTSERIGLVKQRKASLEKAVNDALLLYKSGMATYLEVITAQNNSLQNDLEAINIQKEKYDAVTELYRALGGGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPA5</accession>
    <name>D7VPA5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YceI-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993582.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12825"/>
    <dbReference type="EnsemblBacteria" id="EFK57752">
        <property type="protein sequence ID" value="EFK57752"/>
        <property type="gene ID" value="HMPREF0766_12825"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071003_2_2_10"/>
    <dbReference type="OrthoDB" id="1767227at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107198" evidence="1">
        <location>
            <begin position="20"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="YceI" evidence="2">
        <location>
            <begin position="44"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="211" mass="22466" checksum="CB2EC2921BFD349A" modified="2010-10-05" version="1">MKKIILFSAFAALVLSSCAGNPEGKKAETSDSTAIVENTVSGNSFTVDTAQSKVVWTGTKVTGQHTGTVVVKSGSIQIDNNTLVGGTFTLDMNSISSTDLEGEYKDKLDGHLKAADFFDAAQFPEATFVISKVEAGATASDVKVTGNLTIKGITKSISFDTKVLESTDSVIKTHADFNIERADWGVNYAGKEDDLISKQINFKIDIVANKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPD7</accession>
    <name>D7VPD7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12857"/>
    <dbReference type="EnsemblBacteria" id="EFK57784">
        <property type="protein sequence ID" value="EFK57784"/>
        <property type="gene ID" value="HMPREF0766_12857"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030RNP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133768_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107485" evidence="1">
        <location>
            <begin position="40"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="173" mass="18844" checksum="EC478DDD2F62B144" modified="2010-10-05" version="1">MQSDDRNLTEKQHNIIMKKLLLSFAAAAVLALGAQEAKAQSPQRAAIGVVFDSPFDAFGVQYKTSFGGTNQGQVQVLFGDNVVGIGADYQYARPFRGTNGLGWYVGVGPQISFIDAGSNDFTAIALRPQAGLEFKIPSAPIGLHVDWKPYWQLNHNSDFDASEFSLGIKYTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPD9</accession>
    <name>D7VPD9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_12859</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bTHX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12859"/>
    <dbReference type="EnsemblBacteria" id="EFK57786">
        <property type="protein sequence ID" value="EFK57786"/>
        <property type="gene ID" value="HMPREF0766_12859"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_209110_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030826">
        <property type="entry name" value="Ribo_THX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031414">
        <property type="entry name" value="Thx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17070">
        <property type="entry name" value="Thx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04560">
        <property type="entry name" value="ribo_THX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="51" mass="5420" checksum="307FAFF2A2CF8A33" modified="2010-10-05" version="1">MGKGDKKSRKGKIIMGSYGKKRPRGFQAKAVVPEATDTGKAAVKKKGKETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ01</accession>
    <name>D7VQ01_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993969.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13055"/>
    <dbReference type="EnsemblBacteria" id="EFK55852">
        <property type="protein sequence ID" value="EFK55852"/>
        <property type="gene ID" value="HMPREF0766_13055"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503113Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1748484_0_0_10"/>
    <dbReference type="OrthoDB" id="1970518at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021417">
        <property type="entry name" value="DUF3060"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11259">
        <property type="entry name" value="DUF3060"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107133" evidence="1">
        <location>
            <begin position="24"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="149" mass="15985" checksum="60ABFC09D329B2C9" modified="2010-10-05" version="1">MKKITAVLCSMTMLLGAGVYVKANDNTDGLRHSMVQKQGKEIKVSGKGNTRTIKCTGTETVSVEGMDNKVTIVGKCAKLEVEGKSNTVKAEKVGKISIEGAENMVNADQVETISIEGMKNHVHYKKSSSKSGDADVTTEGIDNMVMKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ17</accession>
    <name>D7VQ17_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993990.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13071"/>
    <dbReference type="EnsemblBacteria" id="EFK55868">
        <property type="protein sequence ID" value="EFK55868"/>
        <property type="gene ID" value="HMPREF0766_13071"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503134Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089930_0_1_10"/>
    <dbReference type="OrthoDB" id="1574258at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027056">
        <property type="entry name" value="Gluconate_2DH_su3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13618">
        <property type="entry name" value="Gluconate_2-dh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="210" mass="23574" checksum="E96D819401DA3848" modified="2010-10-05" version="1">MNRREALQRVALLMGGTVIGANLFLEGCSRSASKDTAKLFEKDSVNFLGDLAEAILPKTSTPGAKEAGVGEFIPVMIRDCYADTEQKVFLDGINTVDDRAKKEFGKKFQELSKEDQTKFVNILDKEASEYNAKQAEATKAQREKDALKQNEMYRVPKSDPPHWFTMFKQLTLTGFFTSELGATKALRYVKIPGKFDGNYPYKKGEHAWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ22</accession>
    <name>D7VQ22_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993995.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13076"/>
    <dbReference type="EnsemblBacteria" id="EFK55873">
        <property type="protein sequence ID" value="EFK55873"/>
        <property type="gene ID" value="HMPREF0766_13076"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_10_3_10"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107136" evidence="2">
        <location>
            <begin position="26"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK55873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="456" mass="51555" checksum="E9CC899CAC86C793" modified="2010-10-05" version="1">MKFFNTGRLALSILLTGFVTVSSQAQEVLDAYVLEAFRNNIVLQQKDVTLEKAQYALKTAKSLFLPTVAFQGAYQTADGGRNIPLPLGDLLNPIYTTLNQLTQSSQFPVMENQSINFLPKNFYDAKIRTTMPIINTDLTYNKRISEQQVVLQQFEVVIYKRDLVKNIKTAYYNYQSALQAVDIYRSGLQLANEGLRVNEKLLEGGKGLPAYVLRSRSEVEQANAQLVAAEQQVLNARMYFNFLLNRNAETNIDADTDNKAGLDKVSTLLADLSQSEKREELKAMDQIVEINRTALKMNKQYAVPKLAAFVDLGSQSEGFKFNNNTRYYMLGLQLDIPIFTAGRNDIKVRQSNLDLRNAELQVDLVSQQLNLATRTAQNNLKAVYQNYQSSLKQFEAASSYQRLIEKGYKAGTNTFIETIDARNQYTSAQLLVNINRYKVLAAMADLERETASYLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ23</accession>
    <name>D7VQ23_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13077</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993996.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13077"/>
    <dbReference type="EnsemblBacteria" id="EFK55874">
        <property type="protein sequence ID" value="EFK55874"/>
        <property type="gene ID" value="HMPREF0766_13077"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_1_2_10"/>
    <dbReference type="OrthoDB" id="1432684at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107432" evidence="2">
        <location>
            <begin position="22"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="52"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK55874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="350" mass="37871" checksum="79A0A11042FF8948" modified="2010-10-05" version="1">MKMNISYPVLLLVALSLSACGNNKSQTSTIANQDTIPVKIMMLQMEDANHAIQSSGQFTTNDETFLSFKNGGIINKIYVKEGDPVRKGQLLASVNQTEISAQVQQVTLSYQKAQRDYDRASQLYRDSVATLEQMQNAKTALQVAKQQLDAIKFNQNYSEIRATSNGYVLKKLANDGQVVGPGTPVLQINGANQSKWVLKIGLSDEQWAALKIGDRADITTDALPQTVLQAKVSRKAEGIDPQSGTFGVELTLDEANTKGLAAGLFGKATIIPTKTTSSYSIPYDALLDAGENEGYVFVTDDEKTAKKVKVKLGTLLKDKINISGGLEEARALIISGSAYLTDGSKIKIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ28</accession>
    <name>D7VQ28_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DJ-1/PfpI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hchA</name>
        <name evidence="3" type="ORF">HMPREF0766_13082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994003.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13082"/>
    <dbReference type="EnsemblBacteria" id="EFK55879">
        <property type="protein sequence ID" value="EFK55879"/>
        <property type="gene ID" value="HMPREF0766_13082"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066933_0_0_10"/>
    <dbReference type="OrthoDB" id="1152952at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036524">
        <property type="term" value="F:protein deglycase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017283">
        <property type="entry name" value="HchA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037798">
        <property type="entry name" value="Chaperone_HchA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="74"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK55879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="283" mass="31245" checksum="133378F1B716F359" modified="2010-10-05" version="1">MTKELSKDPVFDGTGYEPSAFSRAMFVTPKTDYDHTVYENANSNKNKKILVVCTEERYMEMKNGKKFSTGNHPVETLVPLLHLEAAGFEADIYTATGKPVALEMWAIPSEDKAVKEIMAKYEDQFDKPKSLQQFVADGMQTSTEYVAVFIPGGHGAMLGLPENEDLKKIINWSIDKDIFMLAICHGPAALLAASVKESPEDFPYKGYQINSFPDEIDTKTPEIGYVPGEMPWFYGAKLEALGIEILNMDISGACHVDRKLITGDSPLAANAFGKVSAKALLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ34</accession>
    <name>D7VQ34_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bar</name>
        <name evidence="2" type="ORF">HMPREF0766_13088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994015.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13088"/>
    <dbReference type="EnsemblBacteria" id="EFK55885">
        <property type="protein sequence ID" value="EFK55885"/>
        <property type="gene ID" value="HMPREF0766_13088"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_4_3_10"/>
    <dbReference type="OrthoDB" id="1809950at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="163" mass="18604" checksum="597DD1A7D668B313" modified="2010-10-05" version="1">MQFRHAILSDLIRIVEIYNSTVASRVVTADTEPVSTNSRIPWFEKHDTEKRPLWVLENEEGQIIGWISFQSFYGRPAYQATVEISIYLDEAYRGQGLGKLAIDYAIQQAPAYGIKTLLGFIFAHNTASLHLFEHFGFEEWAMLPDIAELDGIERSLKILGKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ78</accession>
    <name>D7VQ78_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994084.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK55929">
        <property type="protein sequence ID" value="EFK55929"/>
        <property type="gene ID" value="HMPREF0766_13132"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7RS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042917_0_0_10"/>
    <dbReference type="OrthoDB" id="1361366at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021365">
        <property type="entry name" value="DUF2891"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11199">
        <property type="entry name" value="DUF2891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="366" mass="41880" checksum="1EEEA7669D0BE689" modified="2010-10-05" version="1">MMNRIILILPVLFVLFSCQSTEKKNDPAQDSVRSIQLDAQQARRILDLPLHCLTTEYPNKLGQVIGSAQDLKTPKQLRPVFYGCFDWHSSVHGYWSIIKILKIYPDLDKDGHIRQLLNQHITPENVQVELAFFQDKNNLGFERTYGWAWLFKLQEELLSWNDKDALQWAKNLQPLVDILVDRYTAYLPKLVYPIRSGQHDNSAFGFSLSLDYARAVGNKEFENVLAGHAKRLYTQDKNCDLAYEPSGSDFLSPCLEEAFVMSKILPQAAYKTWLKSFMPQLFEADFSLKPAVVKDRTDGKLVHLDGLNFSRANCLNGIAKALPELHHLKRVGHEHLAFSLPNISNDDYMGSHWLGTFALYAIAHQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQH2</accession>
    <name>D7VQH2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994287.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13226"/>
    <dbReference type="EnsemblBacteria" id="EFK56023">
        <property type="protein sequence ID" value="EFK56023"/>
        <property type="gene ID" value="HMPREF0766_13226"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032JAR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129882_0_0_10"/>
    <dbReference type="OrthoDB" id="1782106at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032168">
        <property type="entry name" value="DUF5004"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16395">
        <property type="entry name" value="DUF5004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="151" mass="17327" checksum="03E6DD0875E4C321" modified="2010-10-05" version="1">MKTIFISPLIAMCVLASCNNTPEEKINTLSGSWKLIESKTIKEKDTTIAFTDTSKTEMIKMFNDTDFAFFNHDKSKGKDSTAFFVSGSGKYILKGDQYRENLQYCSLRDWEGKSFDFTLTMKGDTLIQKGIEHIPELNVDHEIIESYIRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQJ1</accession>
    <name>D7VQJ1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994330.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13245"/>
    <dbReference type="EnsemblBacteria" id="EFK56042">
        <property type="protein sequence ID" value="EFK56042"/>
        <property type="gene ID" value="HMPREF0766_13245"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033054">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138519_0_0_10"/>
    <dbReference type="OrthoDB" id="1989788at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="166" mass="18402" checksum="F6BB4FE9613578C9" modified="2010-10-05" version="1">MIKRIFLFTLSAGFLAVSCQSNTNQNNSENAADTSENVLSEKIPDIPFTEAERYFVKNTYNNSKTEELKITSQEEFDRIFGMAAVMGEDGTPTSIDFAKVYVLAVIGTVTDTATTISASALKQVGDHLVLDYTVKEEGKQSFTVHPVLLVLVDKQYQGEVRFNKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQK3</accession>
    <name>D7VQK3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994357.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13257"/>
    <dbReference type="EnsemblBacteria" id="EFK56054">
        <property type="protein sequence ID" value="EFK56054"/>
        <property type="gene ID" value="HMPREF0766_13257"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_820969_0_0_10"/>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="339" mass="37693" checksum="10733689E7CD1033" modified="2010-10-05" version="1">MNRDLVQLEEEILAPSAALIADIKRIEGDIMLLGIGGKMGPSMGRLAVRAIREAGLSKRVIGVSRFSDNKVKSELEAYGIETISCDLLNQEELQQLPQVPNIIYLAGHKFGTTGNEDFTWAMNTYLPGMVAQHFRNSKIVAFSSGNVLPFVPVTSGGVSEESSPEPVGEYAQSCLGRERIFQYFSKKNQTEVLIYRLNYAVDFRYGVLVEIAKAVLQDKPIDLRTENVNVIWQGDANEIALRSLLHCEAPAKMLNVTGPETLSTRWVAERFAAIFGKTAHFEHEPAGTALLNNASECHRLFGYPRVTIREAIDITARWLTEGGDLFNKDTHFQERGGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQV9</accession>
    <name>D7VQV9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma factor regulatory protein, FecR/PupR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13363</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994499.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13363"/>
    <dbReference type="EnsemblBacteria" id="EFK56160">
        <property type="protein sequence ID" value="EFK56160"/>
        <property type="gene ID" value="HMPREF0766_13363"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050192_1_0_10"/>
    <dbReference type="OrthoDB" id="1381035at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032508">
        <property type="entry name" value="FecR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16344">
        <property type="entry name" value="DUF4974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="147"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4974" evidence="3">
        <location>
            <begin position="282"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="355" mass="39825" checksum="F8A393D238362BA1" modified="2010-10-05" version="1">MHIPKEVQDAIQKVNSGISTPEDRAVITDWYNSFDDSSAVVDAATNEEEIKSRILQAINRRKPAKPLRRVLYYRIAAAASALLIMGYLAFRLYPDQPADLSIQAGVHLNYTDGEQQQINSTMEAFLDSTAFDNLSAYQKNRSEQLLTLSTAKGQLYKFVLNDGTKIWLNAGSKLTIMPAFNEQTRTVKLIGEAYFEVAKNEKVPFEVISDNQTIRVLGTKFNVKAYHDEASITHLYEGKIALNTPVQSEIVLPGQAVINELGRLEAKQEDQSVSKEWTSSIFSFSNQNMTDILTNLSRFYNVQLDYQSPVPDKLFTGKIQRNSSLSDVLDMLSAVSGGIFKIKDRTVSIEFKNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQY5</accession>
    <name>D7VQY5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_13389</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994529.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13389"/>
    <dbReference type="EnsemblBacteria" id="EFK56186">
        <property type="protein sequence ID" value="EFK56186"/>
        <property type="gene ID" value="HMPREF0766_13389"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_0_1_10"/>
    <dbReference type="OrthoDB" id="448804at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="21"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="296"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="600" mass="68180" checksum="0A2C64EB9C817755" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR22</accession>
    <name>D7VR22_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron chelate uptake ABC transporter, FeCT family, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_13426</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994586.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13426"/>
    <dbReference type="EnsemblBacteria" id="EFK56223">
        <property type="protein sequence ID" value="EFK56223"/>
        <property type="gene ID" value="HMPREF0766_13426"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050494_0_0_10"/>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK56223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="316" mass="36180" checksum="085AE7BC9BA0ADCA" modified="2010-10-05" version="1">MKQQSRIWIMLALFATLIVLFLFYDMGRNIDYVLPRRAIRLATIIVVGISVAYSSMIFQTITNNKILTPSIMGYESIFILFQTIIVFVYGDKTFQVISQTDNFFYAILLMLFFSWVMYMLIFGKGKRNIYHLLLIGLILGTLFQTLSQFMQIVIDPNEFSVIEGYMFVSFNKMNSSLLLIASVVLLATLLWAQRYVKYLDVIALGREHAVNLGLDYNRLIKRYMLIISLLVSVSTALVGPVTFLGILVTNLTYELIPSSRHKVMIWICGLIACIALIAGQFMVEHVFNFSTTVSIVINFSGGVYFMYLILKSRKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRA2</accession>
    <name>D7VRA2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="10">APRT</shortName>
            <ecNumber evidence="5 10">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">apt</name>
        <name evidence="12" type="ORF">HMPREF0766_13506</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="5 10"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994688.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13506"/>
    <dbReference type="EnsemblBacteria" id="EFK56303">
        <property type="protein sequence ID" value="EFK56303"/>
        <property type="gene ID" value="HMPREF0766_13506"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063339_3_0_10"/>
    <dbReference type="OrthoDB" id="1532478at2"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="11">
        <location>
            <begin position="37"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK56303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="176" mass="19638" checksum="0CE12E662C3E3AD8" modified="2010-10-05" version="1">MIEQRLREVIRDIEDFPKPGIVFKDITPILKDAELCTAVVEAFVQRLEGKRIDAVAGIESRGFLFGMMLANRLNLPFIPIRKQGKLPYNTISESYALEYGQATIEVHEDAFEAGQHILIHDDLLATGGTVVAASKLIEKLGGQVAGFSFVISLDFLHSQGRLTRFNHDIISLVHYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRC7</accession>
    <name>D7VRC7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994714.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13531"/>
    <dbReference type="EnsemblBacteria" id="EFK56328">
        <property type="protein sequence ID" value="EFK56328"/>
        <property type="gene ID" value="HMPREF0766_13531"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105410_0_0_10"/>
    <dbReference type="OrthoDB" id="1812417at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025833">
        <property type="entry name" value="GDYXXLXY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14345">
        <property type="entry name" value="GDYXXLXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="164" mass="19088" checksum="1E2C5621486C7089" modified="2010-10-05" version="1">MKKYKWFIILFNLLLLLGYFTYSIRAKEEILDEGQLVLLELAPVDPRSLMQGDYMNLRYAISRDIDTETEKLSRRGYCVIKIDGHGVGKKVRFQRDPSPLDKGEYLIKYTSPNEWIINIGAESFFFQEGHAEKYERAKYGALRIDKNGNSLLVGLYDQGHKEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRM1</accession>
    <name>D7VRM1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase, C-terminal domain protein</fullName>
            <ecNumber evidence="9">1.3.8.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">bcd2</name>
        <name evidence="9" type="ORF">HMPREF0766_13625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.1" evidence="9"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994857.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13625"/>
    <dbReference type="EnsemblBacteria" id="EFK56422">
        <property type="protein sequence ID" value="EFK56422"/>
        <property type="gene ID" value="HMPREF0766_13625"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_10"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004085">
        <property type="term" value="F:butyryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="229"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK56422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="383" mass="41728" checksum="CEB145A8470F8152" modified="2010-10-05" version="1">MFVANVDQMELIRQSAADFATNFIKPHIMEWDEAQTFPVELFRKMGSYGFMGIIVPEEYGGAGLGYQEYITILDEISKVCGSIGLSVAAHNSLCTNHILSFANEEQKKKYLPKLATAEWIGAWGLTETGSGSDAGGLTTVAERDGDYFILNGSKNFITHAISSEVAVVITRTGQKGDKKGKTAFIIEKGTPGFSAGKKENKLGMRASETACLFFDNCRVHKDQIVGEEGQGFVQALKLLDGGRISIAALSLGIARGAYECALKYANEREQFNQKIFDFQAVGFKLAEMATQVEAAELLTRQAAFLKESGTKSSKISAMAKLYASEAAVEVSNESVQIFGGYGFTKDYPAEKYFRDAKLCTIGEGTSSIQKMVIAREIQKDARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRW7</accession>
    <name>D7VRW7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrite/sulfite reductase ferredoxin domain protein</fullName>
            <ecNumber evidence="4">1.8.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cysI</name>
        <name evidence="4" type="ORF">HMPREF0766_13721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995100.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13721"/>
    <dbReference type="EnsemblBacteria" id="EFK56518">
        <property type="protein sequence ID" value="EFK56518"/>
        <property type="gene ID" value="HMPREF0766_13721"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0155">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1895">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015667_1_1_10"/>
    <dbReference type="OrthoDB" id="1588103at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="2">
        <location>
            <begin position="48"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="1">
        <location>
            <begin position="123"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="2">
        <location>
            <begin position="324"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="1">
        <location>
            <begin position="402"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="HEPN" evidence="3">
        <location>
            <begin position="586"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="703" mass="79013" checksum="5CEF5E1327808E3E" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS77</accession>
    <name>D7VS77_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AP endonuclease, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995376.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13831"/>
    <dbReference type="EnsemblBacteria" id="EFK56628">
        <property type="protein sequence ID" value="EFK56628"/>
        <property type="gene ID" value="HMPREF0766_13831"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073994_0_0_10"/>
    <dbReference type="OrthoDB" id="1024405at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107316" evidence="1">
        <location>
            <begin position="25"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="AP_endonuc_2" evidence="2">
        <location>
            <begin position="46"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="294" mass="33719" checksum="1BEB3E03A501B54E" modified="2010-10-05" version="1">MGKIKLLITAILALLAMQHLQASATFKIRFYATNWGMNQSWDSYCEQVKKAGYDGLEVWVPGSKEEQKQMFDAFRKYNLAYAFLSGGGGATFEQYYDSYVKNVEMAVQLKPDFVNCHTGKDYFTFEQNKKLIEAADVISKKYNIPVMHETHRGRFSFAAHITRQFLEQIPQLQLTLDISHWCNVHESLLSDQTETVAMALARTGHIHARIGQPQAPQVNDPAAPEWKSTVDQHLTWWDEVVRLRKEAGKNQLTITTEFGPSGYLPTLPYTQQPVADQWSVNVYMLNLLKSRYQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSA9</accession>
    <name>D7VSA9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ser/Thr phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995454.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56660">
        <property type="protein sequence ID" value="EFK56660"/>
        <property type="gene ID" value="HMPREF0766_13863"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025443_6_0_10"/>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="149"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="393" mass="44870" checksum="40F534770D1AD932" modified="2010-10-05" version="1">MAKRLILILLLFLVADVYFYQAVSTLTENTWIRAIYWSVDVLLFAGIIAIVFLRKAGNNLQRFIPMLITAMLVIFIPKLFSFPILLAEDIVRLLRGFPARSLYVSEATLALAVIMILIILFGLTRGKHFYRVRKETLYFPDLPEVFDGFTITQLSDIHSGSLNDIKGVQKGIDLANAQNSDLLLFTGDLVNNMATEMDPWIPYFTKLKAPYGKYSVLGNHDYGDYIRWDNKEAKEANLNRLKEVHAETGFRLLLNEAVIINKQGQSIALVGVENWGKGGFHQYGDLKEATAHIPDDAFKILMSHDPSHWDEVTVDHNQHVHLTLAGHTHGMQFGIELFGFKWSPIQYFYKQWAGLYQRDGKYLYVNRGFGYHGLKGRVGVWPEITVLTLKRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSE5</accession>
    <name>D7VSE5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995531.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13899"/>
    <dbReference type="EnsemblBacteria" id="EFK56696">
        <property type="protein sequence ID" value="EFK56696"/>
        <property type="gene ID" value="HMPREF0766_13899"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044987_0_0_10"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107623" evidence="2">
        <location>
            <begin position="24"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="461" mass="51091" checksum="C2F160AAE65F4B84" modified="2010-10-05" version="1">MIKHIMATALFWSAVVVMFPIHAQQQKEHTLGSLWSEVEENYPGVSVRASAIAAAKFNQRAVKGNMLPQINAQAQNTYGTYEGSAGAFFPQAGFFNVSGSAIPLGGSSVAANTFGSATIQWEVFSFGKLSKQNEAAGALYHKSVSEKDAYLLNLKKALSERYIILLYNNAKLQWVEKNAKRLNDIRKITSAMSASGLRPAADSLLASSSYVQAMGEHDKWKGFVKAAYIKLLDLYGHDTINYTASANRFENMAENRFGKSKIINVSHPVLDALDKQSEYYMLSGEAQKKSSLPSINLLGGYAYRGTGISPNGTVSGAWKDGFNNTTSNFLAGIGITWNLTSLYTNRMKGQQLFKEAESSRFLHAQYEQAMQADLSAAQAKIIQQYSQLQKTKLAVQQSKDAYHMYQARYKSGLITLSELLQIRILLEQAENAHIEASRDYWVLLAYEAELTADFDFLFNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSH7</accession>
    <name>D7VSH7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995584.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13931"/>
    <dbReference type="EnsemblBacteria" id="EFK56728">
        <property type="protein sequence ID" value="EFK56728"/>
        <property type="gene ID" value="HMPREF0766_13931"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100689_4_0_10"/>
    <dbReference type="OrthoDB" id="1694303at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="111" mass="13101" checksum="81097018903A62A8" modified="2010-10-05" version="1">MKRYTLGLDLVDDPKLINEYETYHAAVWPEIKKSITDAGVESMEIYRFANRLFMIMEVNDSFSFERKGEMDSLNPKVQEWEELMWKYQVAIPGAKTGEKWVLLDKIFDLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSJ9</accession>
    <name>D7VSJ9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995610.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13953"/>
    <dbReference type="EnsemblBacteria" id="EFK56750">
        <property type="protein sequence ID" value="EFK56750"/>
        <property type="gene ID" value="HMPREF0766_13953"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3015">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095662_0_0_10"/>
    <dbReference type="OrthoDB" id="2029962at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007298">
        <property type="entry name" value="Cu-R_lipoprotein_NlpE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04170">
        <property type="entry name" value="NlpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107629" evidence="1">
        <location>
            <begin position="22"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="157" mass="17011" checksum="06C4EF49706A13DF" modified="2010-10-05" version="1">MKKLILSITGAALVLISCQNASTTTTSEKSDSIAALVKKDSAGEFSNPDPAHNSQNALDWDGEYEGVLPCADCEGIKTNVILHKDNTYSLVSEYLGKKSTFKEEGKFTWDDSGSVVTLKLKDGTNKFKVQEGSLKMLDQEGNVITGSLEANYILKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSP9</accession>
    <name>D7VSP9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase enzyme family</fullName>
            <ecNumber evidence="2">3.1.6.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mdsC</name>
        <name evidence="2" type="ORF">HMPREF0766_14003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995702.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14003"/>
    <dbReference type="EnsemblBacteria" id="EFK56800">
        <property type="protein sequence ID" value="EFK56800"/>
        <property type="gene ID" value="HMPREF0766_14003"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037718_0_0_10"/>
    <dbReference type="OrthoDB" id="1003984at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="28"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="373" mass="42812" checksum="CDD6CD2639043014" modified="2010-10-05" version="1">MSDLNSVNIDRNLYIASQFAIDGEVIDVAPFGSGHINDTFKVVTTSTTKYLLQRINHHIFQDVDGLMENIRLVIERLKEDYKSKGLEKAEIDKRVLTLIATRNGLAYYKDEDGDYWRMFILLDHTKSYDVVETTVQAYEGGKAFGHFQKQLSELDANKLVEILPNFHNVEFRLSNLRNAIASDQVSRVGEVQDLLDYIFSLEDRMKTILDWGKANKLPLRITHNDTKFNNVLLDQDDQAQCVIDLDTVMPGFVAYDFGDAIRTIINSGAEDEEDLSRVTLNIPLFEAYANGYMSEAKVFLTDYEKNSLLPGVFLLPYMQAVRFLTDYLEGDHYYKIHYTDHNLVRTKSQLKLVKELELHEDKLKEILTSAVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSV7</accession>
    <name>D7VSV7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995845.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14061"/>
    <dbReference type="EnsemblBacteria" id="EFK56858">
        <property type="protein sequence ID" value="EFK56858"/>
        <property type="gene ID" value="HMPREF0766_14061"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50311Q0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176977_1_1_10"/>
    <dbReference type="OrthoDB" id="2049203at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021448">
        <property type="entry name" value="DUF3098"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11297">
        <property type="entry name" value="DUF3098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="85" mass="9105" checksum="5112A2BDCA9E75BE" modified="2010-10-05" version="1">MAQTNKTTKSSTAKAGNYTGGFVFGKINYQLFAASVAIVIIGFFLMSGSSDIYSFTKITLAPIVVVLGFAIGFVAILYRPKNKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT00</accession>
    <name>D7VT00_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine Rich Repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995919.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14104"/>
    <dbReference type="EnsemblBacteria" id="EFK56901">
        <property type="protein sequence ID" value="EFK56901"/>
        <property type="gene ID" value="HMPREF0766_14104"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_885390_0_0_10"/>
    <dbReference type="OrthoDB" id="883339at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="314" mass="35287" checksum="12025BC37C90F7DB" modified="2010-10-05" version="1">MKQLFNLILICLLPAFSMGQEIMMSPAIFNELKLKLTNDSVLFLNKAAEINTFDLDKIKCIEITALNKQSPALDSDILDKIFNHTPHLEELVLHSNLTGLPEISSPGKKLRVLDLSRNNLDIIPEGIGQLTALEILRCDYNEHLKALPQSIAQLSKLQLLSLYGTGFEEFPEEIFSLSTLTKLYVTGHPQIGTQVKTPKKINSIPDQFAKLPELTDLSIRYTNISTLPASITKLLKLEELSLSGNAFKTFPDQLKAMKGLVIVDFGNNPVDPKTFINSLHNMKWRGLLYLHDLGLDKVQQEKIQTLLSTIDVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTQ5</accession>
    <name>D7VTQ5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein HU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hup</name>
        <name evidence="2" type="ORF">HMPREF0766_14375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14375"/>
    <dbReference type="EnsemblBacteria" id="EFK55814">
        <property type="protein sequence ID" value="EFK55814"/>
        <property type="gene ID" value="HMPREF0766_14375"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105066_2_3_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="135" mass="15058" checksum="FB81AD009F7FDA22" modified="2010-10-05" version="1">MSFSLKNAEIISKARFKAIPLRPQSAVCLRVEIQNNTVKTDMTKAEIIAEISNKTGLEKVDVQETVEAFFKVVKNSMIGGENVYVRGFGSFVVKKRAEKTARNISKNTAIIIPEHFVPSFKPAKVFVEKVKNGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTS4</accession>
    <name>D7VTS4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA pseudouridine synthase</fullName>
            <ecNumber evidence="2">5.4.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rluC</name>
        <name evidence="2" type="ORF">HMPREF0766_14394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002203.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14394"/>
    <dbReference type="EnsemblBacteria" id="EFK55703">
        <property type="protein sequence ID" value="EFK55703"/>
        <property type="gene ID" value="HMPREF0766_14394"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_11_2_10"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="14"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="228" mass="26299" checksum="C8A979685E504BAA" modified="2010-10-05" version="1">MQITDKDVIYEDNHLIAINKRAGDIVQVDDSGDKSLDMMVKEYLERKYEKPNAFIGVIHRLDRPVSGLIVFAKTSKGLDRMNKLFHDRDVEKSYLAVVRNKPEQMSAKLQNWLVRDRKKMITKAYNREIKGSSYAELDYEVIGELEGYYLLHVKPKTGRTHQIRIQLSTMGCPIVGDNKYGYPRGSLRRSICLHSRSLSFVHPVKDEPMKIVAGLPVDGFWEKFNVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTX1</accession>
    <name>D7VTX1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_14441</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002287.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14441"/>
    <dbReference type="EnsemblBacteria" id="EFK55750">
        <property type="protein sequence ID" value="EFK55750"/>
        <property type="gene ID" value="HMPREF0766_14441"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_1_10"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK55750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="212" mass="23514" checksum="CD9BA0131BAECE8E" modified="2010-10-05" version="1">MKKILIADDHSIVRLGASVIIKGVIENANITQAQDYSEITKLLDANRYDLLLLDINMPGGNNIKVIHEILAKQNDLKILVFSSYDESLYALRYIEAGAVGYLNKNTAMSELGNAIQCIISRGKYMSDVVTDLYLKKLTQSKSSLQKANPLAKLSNREMDVAKHLTQGLGILEVSNELKLSASTISTYKSRVFEKLGVTNIPELIQLFNLHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGB5</accession>
    <name>D7VGB5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aspC2</name>
        <name evidence="3" type="ORF">HMPREF0766_10034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001907.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10034"/>
    <dbReference type="EnsemblBacteria" id="EFK60090">
        <property type="protein sequence ID" value="EFK60090"/>
        <property type="gene ID" value="HMPREF0766_10034"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_10"/>
    <dbReference type="OrthoDB" id="554560at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="14"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK60090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="380" mass="41768" checksum="B9D02CBA2C4E110E" modified="2010-10-05" version="1">MTKLGRELAAKGVNVISLSVGEPDFNTPDNVKEAAKKALDENYTRYSPVPGYPELRQAIVNKLKNENGLNYDISQIVVSTGAKQSLSNVLLTLVNPGDEVIIPTPYWVSYSEMVVLAEGKSVFIDTEIDQDFKITPAQLEAAITPKSKVFMFSSPCNPTGSVYSKEELAGLVAVFEKHPEIYIISDEIYEHINFVDQHESIAQFESIKDRVIVVNGFSKAFAMTGWRLGYIAANKEIAAANDKMQGQTTSGTCSISQRAGIAAYEGGLESVNKMKEAFARRRQLVYDLLNDIPGVKTNLPQGAFYFFPEISSFFGKKDSNGNIIQNSADLALYLLNEGHVATVGGDSFGNNNYIRLSYAASDENLKEALRRIKEALSKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGE5</accession>
    <name>D7VGE5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10064"/>
    <dbReference type="EnsemblBacteria" id="EFK60120">
        <property type="protein sequence ID" value="EFK60120"/>
        <property type="gene ID" value="HMPREF0766_10064"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1894863_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="134" mass="15582" checksum="75A5C9A7F418FDAE" modified="2010-10-05" version="1">MCRFCNKTAFILLILILIANVIICLLYEVPLRNSSVLLIVAVIILIMVRTKANWFAFVALCLYGMYDLFYIGRTSSDALTMDFLYPVEILIQEEYNVRRLKWFVGLLPLLFYLQFLIILVSKTGRREYGIIGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGG7</accession>
    <name>D7VGG7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF87 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10086"/>
    <dbReference type="EnsemblBacteria" id="EFK60142">
        <property type="protein sequence ID" value="EFK60142"/>
        <property type="gene ID" value="HMPREF0766_10086"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_388784_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="1">
        <location>
            <begin position="188"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="710" mass="79527" checksum="B73B2C1489593371" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGN9</accession>
    <name>D7VGN9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10158"/>
    <dbReference type="EnsemblBacteria" id="EFK59241">
        <property type="protein sequence ID" value="EFK59241"/>
        <property type="gene ID" value="HMPREF0766_10158"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_841746_0_0_10"/>
    <dbReference type="OrthoDB" id="1543158at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="250"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="354" mass="40640" checksum="81744527F66C6CAF" modified="2010-10-05" version="1">MKFASATTAIRNCKLIIGIAYMKKLLLNITYTLTPQWLQQFSDQIGTRLIDNKIILFSREIAEGRIYFIELMPGLSVMLRDMIVHQPIHFSRKAKEDDLVFVYYDLSENISTHIVNGVGHMVGLNSPFDMGIVDSSVESSYIPILGERVYSLCLLVSKKLLIKLFKNHIQNNNKNVYFDPERNTLLFYGHIDSRSKLLLHQLKKKSYTDPSFELFFKSTSYRLFGLLIEGFSKISYPSFKLSDIEIKGILATQEYILTQLWVKFPGVSNLARMAGMSESKYKLAFRRVFNDTPNNFFLTEKLFLAKRLLTSGDYNSVLEIAYELGYSKSSYFSAVYRSKFGVLPGSVLVRKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGS7</accession>
    <name>D7VGS7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Asparaginyl-tRNA synthetase</fullName>
            <shortName evidence="5">AsnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">asnS</name>
        <name evidence="7" type="ORF">HMPREF0766_10196</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996836.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10196"/>
    <dbReference type="EnsemblBacteria" id="EFK59279">
        <property type="protein sequence ID" value="EFK59279"/>
        <property type="gene ID" value="HMPREF0766_10196"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_0_10"/>
    <dbReference type="OrthoDB" id="1138123at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00534">
        <property type="entry name" value="Asn_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="6">
        <location>
            <begin position="131"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="481" mass="55273" checksum="9739DAB66DCBEEC4" modified="2010-10-05" version="1">MEHTRIKELLNATEFGQEVIVKGWVRTFRNNQFIAINDGSSINNIQAVVDFENTDDALLKRITTGAAVRVKGTLIESLGKGQKVEVKVTELDVIGDSDPEKFPLQPKKHSLEFLREIAHLRFRTGTFNAIFKVRNALSFAVHRFFNERDFVYMHTPIITGSDAEGAGEMFRVTTLDLNNPPRTENGDIDFKEDFFGKSTNLTVSGQLEGELAALAFGNIYTFGPTFRAENSNTTRHLAEFWMIEPEMAFYELEDNMDLAEALLKYVIQYALETCPEEIEFLKNRLLEEEKNKPAADRSEMDLIEKLKFCLENEFERVKYTDAIEILKRSKPNQKKQFKYLIDEWGADLQSEHERYLVEKHFKKPVILTDYPREIKSFYMKQNEPDALGRNTVRAMDILFPGIGEMVGGSQREENLDKLLARMAEVGIPAEEMEWFLDTRRFGSVPHSGFGVGFERLVLFVTGMTNIRDVIPFPRTPKNAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGU1</accession>
    <name>D7VGU1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Class II glutamine amidotransferase</fullName>
            <ecNumber evidence="16">1.4.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">gltB</name>
        <name evidence="16" type="ORF">HMPREF0766_10210</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="16"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996881.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10210"/>
    <dbReference type="EnsemblBacteria" id="EFK59293">
        <property type="protein sequence ID" value="EFK59293"/>
        <property type="gene ID" value="HMPREF0766_10210"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0069">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_8_2_10"/>
    <dbReference type="OrthoDB" id="5568at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="15">
        <location>
            <begin position="21"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFK59293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1505" mass="166208" checksum="163FFA1C2BD79BD3" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGV0</accession>
    <name>D7VGV0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter, major facilitator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_10219</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996903.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10219"/>
    <dbReference type="EnsemblBacteria" id="EFK59302">
        <property type="protein sequence ID" value="EFK59302"/>
        <property type="gene ID" value="HMPREF0766_10219"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_39_2_10"/>
    <dbReference type="OrthoDB" id="446363at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="13"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="502" mass="55693" checksum="40D43571ECFD2AA1" modified="2010-10-05" version="1">MKETVSKKGIWKVIGASSMGTLIEWYDFFIFGSLSVVISTKFFPSDNPTAAFLSTLATFAAGFVVRPFGALFFGRLGDMIGRKYTFMVTLLLMGGATFLIGCIPSYDSIGFWAPLLVLILRLLQGLALGGEYGGAATYVAEHAPKGQRGYWTSWIQTTATFGLFISLIVILLTKSILSAEQFDAWGWRVPFMLSIIMVYVSYLIRKNMDESPEFQKAKTEGKVSANPLKESFGNRYNLKFVLLALFGAAMGQGVVWYTGQFYSMSFMKTVMFLDSDQADTILGTALLIGTPFFIVFGWLSDKIGRKWIMLSGMLLAILTYRPIYKAMYVVTDIHQKEEVLAKTIRTSGLDKVHNASFETTEKEYSDGTSSKVTTSTTIGEAKETVKTTITIQGKNRVWLTALIFIQIIYITMVYGPIAAFLVEMFPVKIRYTSMSLPYHIGNGIFGGLLPAVSTYLASNAKTAQDPEFYLAGLWYPIIISATCFIIGALYINKSIIHTNVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGZ2</accession>
    <name>D7VGZ2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tat pathway signal sequence domain protein</fullName>
            <ecNumber evidence="2">1.2.7.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hmoA</name>
        <name evidence="2" type="ORF">HMPREF0766_10261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997022.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10261"/>
    <dbReference type="EnsemblBacteria" id="EFK59344">
        <property type="protein sequence ID" value="EFK59344"/>
        <property type="gene ID" value="HMPREF0766_10261"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_306470_0_0_10"/>
    <dbReference type="OrthoDB" id="178823at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030948">
        <property type="entry name" value="MoCo_extend_TAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04519">
        <property type="entry name" value="MoCo_extend_TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="747"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1001" mass="109157" checksum="355A45BF5351409C" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH07</accession>
    <name>D7VH07_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997068.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10276"/>
    <dbReference type="EnsemblBacteria" id="EFK59359">
        <property type="protein sequence ID" value="EFK59359"/>
        <property type="gene ID" value="HMPREF0766_10276"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_5_10"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="399" mass="43884" checksum="B70234143A9990FD" modified="2010-10-05" version="1">MEKTNYGLKELIISLLYYEKSYSIADLSLLIGKSIPSTTKIINELADYNLIIEDGLAPSTGGRRPIKYTINSNLNKFILSVAIDQHYSTAVIYDLSNEERTPVFTIENHLDNHDEVFDNIVGLMEKTLQHGEFNQSNILGIGISMPGFVDNKQGTNGSYKDKNTKLYYIKREIENRFQLPTFIENDSTAIAIAEQNFGKARNTSHSLVINIGWGVGLGIIVDNKLFRGYSGYAGEFSHIPLSDSNKLCSCGKKGCLEVEASLSAAVEFAEEKLQSGEKSKLANHLTNDRLESSNSLIQSALNGDQLAISALTKSGYMLGKGVATLIHIMNPEKIILSGRGSQAGQILMPQIQTAINEFCIPRIAQKTSVEISDLKNKAQLIGSACIVLEYSLSKFVNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHB6</accession>
    <name>D7VHB6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="7">3.5.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nagA</name>
        <name evidence="7" type="ORF">HMPREF0766_10385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997300.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10385"/>
    <dbReference type="EnsemblBacteria" id="EFK59468">
        <property type="protein sequence ID" value="EFK59468"/>
        <property type="gene ID" value="HMPREF0766_10385"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032482_2_1_10"/>
    <dbReference type="OrthoDB" id="1026967at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047419">
        <property type="term" value="F:N-acetylgalactosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="PTHR11113:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="51"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="395" mass="43454" checksum="66AF663FCBAABAC4" modified="2010-10-05" version="1">MQTKIINAKLILPDRIIPNGSLLIREGKIVEIHDSPVESDSETVIDAEGMYVSPGFIDIHVHGGGGYDIMDNTVEAFLGVAATHAQYGTTAMLPTTLTSETADLIDLFHVYEQALLQNKDGARFLGLHLEGPYFAMNQRGAQDPRYIRNPDPAEYEPILRDYHHLIARWSAAPELPGALTFGKKVREKDILLALAHTDAVYAEIVEGLESGYNLATHLYSGMSGMTRKNAYRYAGTIESCLLLDEIHVEIIADGVHLPAPFLQLIHKTKGTERITLITDAMRAAGMPEGKSVLGSLRNGLEVIVENGVAKLPDRSSFAGSVATMDRLIRTMLSETSVSLQEVIRMVSINPARLIKRDQEIGSIAIGKDADLVLFDEDISIHRTIIQGRSVYEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHD1</accession>
    <name>D7VHD1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">recA</name>
        <name evidence="11" type="ORF">HMPREF0766_10400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the RecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997339.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10400"/>
    <dbReference type="EnsemblBacteria" id="EFK59483">
        <property type="protein sequence ID" value="EFK59483"/>
        <property type="gene ID" value="HMPREF0766_10400"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040469_1_2_10"/>
    <dbReference type="OrthoDB" id="1080436at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="9">
        <location>
            <begin position="36"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="10">
        <location>
            <begin position="200"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK59483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="337" mass="36290" checksum="FB33C7C9AFEE711F" modified="2010-10-05" version="1">MSNQDKLKALQLTLDKLEKSYGKGTIMKLGDSAVEPIESISTGSLGLDIALGIGGVPKGRIIEIYGPESSGKTTLATHIVAEAQKKGGIAAIIDAEHAFDKYYAQKLGVDVENLLISQPDNGEQGLEIADNLIRSGAIDVIVIDSVAALVPKGEIEGEMGDSKMGLQARLMSQALRKLTGTISKTNCCCIFINQLREKIGVMFGNPETTTGGNALKFYASVRLDIRRTSQIKDSDEVSGNRVKVKIVKNKVAPPFRIAEFDIMFGEGISKVGEIIDLGVEYNIIKKSGSWFSYGDTKLGQGRDAVKSLLQDNPDLMDELEQKIKAEVSGVEAVVEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHM0</accession>
    <name>D7VHM0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10489</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997552.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10489"/>
    <dbReference type="EnsemblBacteria" id="EFK59572">
        <property type="protein sequence ID" value="EFK59572"/>
        <property type="gene ID" value="HMPREF0766_10489"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022279_1_0_10"/>
    <dbReference type="OrthoDB" id="1384936at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="1">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="223"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="335"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="367"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="391"/>
            <end position="394"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="463" mass="50813" checksum="8B3BA900C2D69FFC" modified="2010-10-05" version="1">MGKKLSGKDLIKLGFPQNNAINIALGQIQRYRKRDKKEAILADARQVLLSPEQFLGDGIWGKVAEGLVRPVEVRLQQLRTSRVAFSIFGENEIDEQAKRQLYDALKLPVAVSGALMPDAHSGYGLPIGGVLATDNAVIPYGVGVDIGCRMSLSVFDLPASYLKGKRFQLTNMLLEQTCFGMYETHKNRADHEIFSRKEFQEIPILKNLLGKAWKQLGTSGGGNHFVEFGIVNLNNPRPEWKLPAGEYVALLSHSGSRGLGANIAKHYTYLAAKQCPLPRSVQHLAWLDLDTHDGQEYWMAMNLAGDYASACHDDIHRRIAKALGKRPAFKVENHHNFAWKQLIDGKECIVHRKGATPAAKGELGIIPGSMTAPGYIVVGKGNESSLQSASHGAGRLLSRAACKASFTPGQVQKLLKDTDVELVGGSVDEAPMAYKDIRKVIALQSELVDILGTFTPKIVRMDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHM9</accession>
    <name>D7VHM9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10498"/>
    <dbReference type="EnsemblBacteria" id="EFK59581">
        <property type="protein sequence ID" value="EFK59581"/>
        <property type="gene ID" value="HMPREF0766_10498"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016091_0_0_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plug" evidence="1">
        <location>
            <begin position="122"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="797" mass="89745" checksum="E01B4F9BB090AAD6" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI05</accession>
    <name>D7VI05_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997880.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10624"/>
    <dbReference type="EnsemblBacteria" id="EFK59707">
        <property type="protein sequence ID" value="EFK59707"/>
        <property type="gene ID" value="HMPREF0766_10624"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1052363_0_0_10"/>
    <dbReference type="OrthoDB" id="1752958at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="40"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="222" mass="25542" checksum="55BADADC67DAC524" modified="2010-10-05" version="1">MIRIQHIWFVFALFILTATVSCEKGDEYYKDYQNNTKVYDGTILKYLESQRGTYDSLLLVLDRAPGLRSKLMGTEKFTFYAMTNRSFEIAVKALNATRKLTNKAPLYLEDVDQLELDSLMGRYIFEGEVTTETLYPYIDGLKAKSIYGYDMHMYYNVTNASGFVSGGQQEIEFSDVNNSIFKRYWQTTTTTAVNLKTTNGVIHFLSASHDFGFNKFTSKFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI17</accession>
    <name>D7VI17_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Efflux ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0766_10636</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997904.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10636"/>
    <dbReference type="EnsemblBacteria" id="EFK59719">
        <property type="protein sequence ID" value="EFK59719"/>
        <property type="gene ID" value="HMPREF0766_10636"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008713_2_0_10"/>
    <dbReference type="OrthoDB" id="177018at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="705"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="746"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="20"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="309"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="690"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK59719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="785" mass="88226" checksum="69D987FEC16479FC" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI41</accession>
    <name>D7VI41_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamine cyclotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997952.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10660"/>
    <dbReference type="EnsemblBacteria" id="EFK59743">
        <property type="protein sequence ID" value="EFK59743"/>
        <property type="gene ID" value="HMPREF0766_10660"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060272_0_0_10"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017186">
        <property type="term" value="P:peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007788">
        <property type="entry name" value="QCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31270">
        <property type="entry name" value="PTHR31270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05096">
        <property type="entry name" value="Glu_cyclase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="344" mass="38117" checksum="6E269BF63850FB41" modified="2010-10-05" version="1">MKKIIGVFAVGAMLLSSCFTKKGKLEFVSPESGKVVILGQKVNLKLNFASAALDSVVYSVDGNIIGRKQDTSSLVVDSQTIGLGNKNLTAKVYAEGKEDMAYSNVLIVPESAKQYGFEIINTFPHDTSAFTQGLEFADGIFYESTGRYGLSSLRKVEVNTGKVLKKLDLDSKYFGEGMTIFGNKIVLLTWENNMGLVFDKATFNQTGTFNYENSKEGWGLTNDGQRLIKSDGSNKLYFLNPETYKEEGSIGVYDENGAVEQLNELEYIDGKVYANVYQKDIIVIIDPKTGAVTGQINLVGMYTNPQRQSFDNELNGIAYDKAGKRLFLTGKKWNQLFEVKLVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VID6</accession>
    <name>D7VID6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH OST-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10755"/>
    <dbReference type="EnsemblBacteria" id="EFK59838">
        <property type="protein sequence ID" value="EFK59838"/>
        <property type="gene ID" value="HMPREF0766_10755"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034061_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12872">
        <property type="entry name" value="OST-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51644">
        <property type="entry name" value="HTH_OST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH OST-type" evidence="1">
        <location>
            <begin position="200"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="276" mass="30817" checksum="A92BE55DF284D858" modified="2010-10-05" version="1">MYTTPIPYPDSPDGYTEMNDSKFNIAVLIDGDNAQASLIKELIAEVSKYGKATIRRIYGDWTSPQMNSWKDILNEYSINPIQKFSYTSGKNSTDSSLIIDAMDILHGKSVDGFCIVSSDSDYTGLAKRIREEGLFVMGIGRKITPIAFVNSCEIFTFTENLVEVEEIAAIPADNKKRPARAIAEKINKKPESVKITKATLPKSEMIKIDKAFSIATNEDDETFIAKIGLALRKIDPSFDARTFGFKNLTQLLDSLDKYEIIKNEVNGLNHPLVKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIE1</accession>
    <name>D7VIE1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
            <ecNumber evidence="2">1.1.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ycdF</name>
        <name evidence="2" type="ORF">HMPREF0766_10760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.47" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998150.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10760"/>
    <dbReference type="EnsemblBacteria" id="EFK59843">
        <property type="protein sequence ID" value="EFK59843"/>
        <property type="gene ID" value="HMPREF0766_10760"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_4_1_10"/>
    <dbReference type="OrthoDB" id="1135906at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047936">
        <property type="term" value="F:glucose 1-dehydrogenase [NAD(P)] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="295" mass="31969" checksum="6EB5CB9E3D9626C1" modified="2010-10-05" version="1">MEEINKPVNPINKYPEPPFRKQEQYPPGLEKGLDPQADHGENSYKGNGLLQGKKALITGGDSGIGKAIAIAFAREGADVIISYLNEDEDAIDTKNWVEAAGANAILMPGDIRDERHCQLLISKAVEEWGGIDILVNNAAYQRTYKDFDSIPADEWREVFDTNVHAMFYLCHEALPYMPEGSSIINTTSVNAYHPNPILLPYAATKAAIQNFTANMAQMMLEADNGIRVNAVAPGPVWTPLIPSTIPDHENFGKDTPMGRPGQPAEIAPVFVFLASSAASYISGATIPATGGKIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIF1</accession>
    <name>D7VIF1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2383 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998168.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10770"/>
    <dbReference type="EnsemblBacteria" id="EFK59853">
        <property type="protein sequence ID" value="EFK59853"/>
        <property type="gene ID" value="HMPREF0766_10770"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114531_0_0_10"/>
    <dbReference type="OrthoDB" id="1769096at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011971">
        <property type="entry name" value="CHP02284"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019052">
        <property type="entry name" value="DUF2383"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016920">
        <property type="entry name" value="UCP029477"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09537">
        <property type="entry name" value="DUF2383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029477">
        <property type="entry name" value="UCP029477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02284">
        <property type="entry name" value="TIGR02284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2383" evidence="1">
        <location>
            <begin position="9"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="153" mass="17706" checksum="80BBFEC1A292C6DF" modified="2010-10-05" version="1">MTTENKTAEIVNDLIEINNDRIEGYTRALEDLKDEENLDLRSLFEDYIQQTRQFNSELNPLVVINGEEPTTGTRTSGKLHRLWLDVKATFSGHDRKSILEECERGEDASKKAYQEALREAPHLPINVVDIIRSQSEKQLQAHDRIRDLRDSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIH5</accession>
    <name>D7VIH5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate racemase</fullName>
            <ecNumber evidence="2">5.1.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">racX</name>
        <name evidence="2" type="ORF">HMPREF0766_10794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.13" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998215.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10794"/>
    <dbReference type="EnsemblBacteria" id="EFK59877">
        <property type="protein sequence ID" value="EFK59877"/>
        <property type="gene ID" value="HMPREF0766_10794"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1794">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055360_2_0_10"/>
    <dbReference type="OrthoDB" id="1359310at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047689">
        <property type="term" value="F:aspartate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004380">
        <property type="entry name" value="Asp_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF7">
        <property type="entry name" value="PTHR21198:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00035">
        <property type="entry name" value="asp_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="247" mass="27105" checksum="653FDB8FC4D76F27" modified="2010-10-05" version="1">MIGIVGGSRPLAGLELIKKILEETIASTDQDHLPVLLSSQPHRIADRTQYLLDNTRTNPAYAIAEIISELEQSGATVVGIPCHTAHAVPIFDIIRYELQKKEHKVRLLHMVEETSDYIAAHFTAPVVGILTTTGIRNTGLYNHVFAAKGLKVIQPPEEWQEKIQAAIHDEQYGIKASSSPVTNRAKEELVAAIHELKKEGATVIILGCTELSGALREKEISGLPLVDPNRILARALIRTVAPEKLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIT2</accession>
    <name>D7VIT2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like protein</fullName>
            <ecNumber evidence="2">1.6.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">naoX</name>
        <name evidence="2" type="ORF">HMPREF0766_10901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.3" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998435.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10901"/>
    <dbReference type="EnsemblBacteria" id="EFK59984">
        <property type="protein sequence ID" value="EFK59984"/>
        <property type="gene ID" value="HMPREF0766_10901"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089574_13_3_10"/>
    <dbReference type="OrthoDB" id="2056793at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="15"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="104" mass="11648" checksum="359A7E68E60FB7F7" modified="2010-10-05" version="1">MKEVSVAELKQKIDNNEDFQLIDVRESFEYEVSNLGGLNIPLAGIVIEAEKISKDKPVIIQCRSGKRSAQAVMLLEQQGFDNLANLKGGILAWKEEIDPELDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ80</accession>
    <name>D7VJ80_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000429.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11049"/>
    <dbReference type="EnsemblBacteria" id="EFK58933">
        <property type="protein sequence ID" value="EFK58933"/>
        <property type="gene ID" value="HMPREF0766_11049"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032797_0_0_10"/>
    <dbReference type="OrthoDB" id="382122at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107558" evidence="1">
        <location>
            <begin position="28"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="576" mass="64818" checksum="09A9D3F08F84DD1B" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJA8</accession>
    <name>D7VJA8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Proton-translocating NADH-quinone oxidoreductase, chain L</fullName>
            <ecNumber evidence="10">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nuoL2</name>
        <name evidence="10" type="ORF">HMPREF0766_11077</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.5" evidence="10"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000516.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11077"/>
    <dbReference type="EnsemblBacteria" id="EFK58961">
        <property type="protein sequence ID" value="EFK58961"/>
        <property type="gene ID" value="HMPREF0766_11077"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_6_3_10"/>
    <dbReference type="OrthoDB" id="1274678at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="9">
        <location>
            <begin position="70"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="8">
        <location>
            <begin position="137"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK58961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="678" mass="75832" checksum="749DD0701252F7E1" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJH4</accession>
    <name>D7VJH4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">der</name>
        <name evidence="11" type="ORF">HMPREF0766_11143</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11143"/>
    <dbReference type="EnsemblBacteria" id="EFK59027">
        <property type="protein sequence ID" value="EFK59027"/>
        <property type="gene ID" value="HMPREF0766_11143"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016077_6_2_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="11"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="182"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="64"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="188"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="235"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="300"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK59027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="441" mass="50086" checksum="C95D40B4B04FF0AB" modified="2010-10-05" version="1">MSRFKITNMANIVAIVGRPNVGKSTLFNRLTESRKAIVDDFSGVTRDRHYESAEWIGKKFTVIDTGGFVHGSDDVFEEAIRDQVYIAIEEASVIIFMVDVTTGITDLDDEIADILRRSTKPVYVAANKVDHAKLHHDSAEFYAFGLGEIYNISSATGSGTGELLDAVVSTFEVEEEEESTLPKYTIVGRPNVGKSSLTNALLGKDRNIVTPVAGTTRDSIRIHYNQFGHEFLLIDTAGMRRKSKVNEDIEFYSVMRTIKALEDSDVVILMLDAQDGIEAQDINIFHLAEKNKKGVMIVVNKWDLIEKDNKTMKEFEARIREKIAPFTDVPIVFTSVTEKQRIHKTLEVAAKVYQNKTKKIPTSKLNEVMLQVIENYPPPAIKGKYIKIKYVTQIPGRSPMFAFFCNLPQYIKDPYKRYVENKLRENFDFEGVPIQLYFRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJJ7</accession>
    <name>D7VJJ7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin-like_fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000689.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11166"/>
    <dbReference type="EnsemblBacteria" id="EFK59050">
        <property type="protein sequence ID" value="EFK59050"/>
        <property type="gene ID" value="HMPREF0766_11166"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_8_0_10"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13098">
        <property type="entry name" value="Thioredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107295" description="Thioredoxin-like_fold domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="2">
        <location>
            <begin position="41"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="155" mass="18026" checksum="764FF8C2D928AD8E" modified="2010-10-05" version="1">MKAVLLNILFLSCLVSAQAQARQEINWLTFEQLSDSLNAQPKETLLFFYTDWCSYCHKMMKEGFQNPDIVRYINTHYYAVRFDAESISPVNFDGQVLKNTSKHKVSGHFHEVALLFNPPGKKLIFPQLILLKNDFSIKKNTNKYLSSKELLKYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJM9</accession>
    <name>D7VJM9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative L-rhamnose catabolism isomerase</fullName>
            <ecNumber evidence="2">5.3.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rhaI</name>
        <name evidence="2" type="ORF">HMPREF0766_11198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.14" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000756.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11198"/>
    <dbReference type="EnsemblBacteria" id="EFK59082">
        <property type="protein sequence ID" value="EFK59082"/>
        <property type="gene ID" value="HMPREF0766_11198"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4952">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059875_0_0_10"/>
    <dbReference type="OrthoDB" id="283831at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008740">
        <property type="term" value="F:L-rhamnose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="100"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="424" mass="47324" checksum="1CC966A7BD3FF3BB" modified="2010-10-05" version="1">MLIKDSLIEEYNNLHLDAHKRRFTFLAETLSNTEEILQKLGVFQIAIPSWALGTGGTRFGRFSGQGEPGTLEQKIEDVGLLHKLNRSSGAISLHIPWDIPQDAEAIKQLASYHGLVFDAVNSNTFQDQKDQKYSYKFGSLHHVDPHVRQQAIDHNVEVIRHGIALGSKALTVWLADGSSFPGQLNFREAFQNTLSSLKEIYKHLPSDWKLFVEYKGFEPFFYSTTIADWGQSLLLANKLGDQAYTLVDLGHHLPNANIEQIVSLLLMEGKLGGFHFNDSKYADDDLTAGSIKPYQLFLIFNELVEGMDARGMDHATGLGWMIDASHNQKDPLVDLLQSVEAIKIAYAQALLVDRAALKEAQQQNDVVKAQEILQDAFRTDVRSIVAESRLREGGALNPVELYRQLGVRNILTQERGTASVATGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJQ1</accession>
    <name>D7VJQ1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000813.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11220"/>
    <dbReference type="EnsemblBacteria" id="EFK59104">
        <property type="protein sequence ID" value="EFK59104"/>
        <property type="gene ID" value="HMPREF0766_11220"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_19_0_10"/>
    <dbReference type="OrthoDB" id="2045232at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="77" mass="8726" checksum="56403DE9008799AD" modified="2010-10-05" version="1">MARIIKFEKNDCAPCAQVSAYLDQKGIQYETINPFDQPELAVKFKVRTVPTVIVLEDEEIKSRIIGFKPEELASIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJX6</accession>
    <name>D7VJX6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ycdC</name>
        <name evidence="3" type="ORF">HMPREF0766_11295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998714.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11295"/>
    <dbReference type="EnsemblBacteria" id="EFK58578">
        <property type="protein sequence ID" value="EFK58578"/>
        <property type="gene ID" value="HMPREF0766_11295"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_12_10_10"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="202" mass="23404" checksum="4BCDA5A0C47A7551" modified="2010-10-05" version="1">MDNTQKKKNQIVKAALKRFAHFGIPKTTMSEIADDVHLTKANLYYYFPDKISLIKDSILAIVAEMDVVERDAMNTEKGGVLVLLNRLLDIRAFFVKKYYMFYIFENVDWIKDPGISLEIDSLIQQDEDQYCEIFEKAKDKGELADLDPRYLAKNYSDTMRGLGLMGNVTNIIQGYPSIDNLDDILKRQKEVTEIMFHGMRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJY8</accession>
    <name>D7VJY8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription antitermination factor NusB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nusB</name>
        <name evidence="7" type="ORF">HMPREF0766_11307</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NusB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11307"/>
    <dbReference type="EnsemblBacteria" id="EFK58590">
        <property type="protein sequence ID" value="EFK58590"/>
        <property type="gene ID" value="HMPREF0766_11307"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058797_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusB" evidence="6">
        <location>
            <begin position="188"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="304" mass="35526" checksum="F7FA7F35CF9C8024" modified="2010-10-05" version="1">MQTLYAYSLSSDKQVKNYEKALLKSVDEVYEMYIWTLNLLDEVSEYVLIDAEGRANKFLPTEKDLSLTTRLNNNTFIESLRQNRDYLEGVKKYKVDWSFDPEIVRSIFAQLKESDIYLEYLQSEDRSIATEKDIIKHIFKKIILKSPNIEQTFEDKFINWPVDKEVLQALIAKTFKNFSSEIPQQNKLAELTQNWLDDREFVLDLLANTIRYGEEYQSLIAAKTKNWEADRIALLDTILMRMAICELINFSSIPVKVTINEYIELSKVFSTLKSNTFINGILDKILADLNQQGRIRKQGRGLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJZ5</accession>
    <name>D7VJZ5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK58597">
        <property type="protein sequence ID" value="EFK58597"/>
        <property type="gene ID" value="HMPREF0766_11314"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2304234_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="100" mass="11610" checksum="D793E27BEA753E27" modified="2010-10-05" version="1">MKTSVEMKKQNIQDSNYPKRESNFLTTITSEDTFQVIIDNAGSSTLLLWQDEYYMEAYLSHCEIPITLSKVDSVIFLKMDKRQPSGAEFLYSSCIWTRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK43</accession>
    <name>D7VK43_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_11362</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998911.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11362"/>
    <dbReference type="EnsemblBacteria" id="EFK58645">
        <property type="protein sequence ID" value="EFK58645"/>
        <property type="gene ID" value="HMPREF0766_11362"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2913">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_3_5_10"/>
    <dbReference type="OrthoDB" id="406005at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106972" evidence="5">
        <location>
            <begin position="22"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="SusD-like_3" evidence="7">
        <location>
            <begin position="24"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="6">
        <location>
            <begin position="360"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="475" mass="54548" checksum="BB4B58083B9A663B" modified="2010-10-05" version="1">MKLKNKYLFFFLLACSLYGTACTKWLDIRPKTEVSEIVLFENEQGFKDAMTGVYTQMASRNLYGQEATMGLMEVLAQNYDVDLNTHIYYEAGNYNYLNLMTRPKIDAIWSSSYKAIANLNNLLKQIDQKQNVFSGVNYQIIKGEALALRAFLHFDLLRAFGPVPVGNMDAEAIPYRREFDMNIKPSLSLRQVTDECINDLNAAGKLLAADKNVYYGHSDVYRAFTRNHMNYWAVTGLMARIYLYRGDKVLAYQKAKEVIDAKLFPFINSSAISNSNSAPDRIFSTEHLFAVYVANLRDINDELFRATVDASDILTNTTDFINSRFETGSGGSTDYRYLNLWKTDGPTAIKFPVKYRFDDIGSNANITTIKRVPLIRLSEMYYICAETSNDKDEKIDLLNEVRTNRGLHVLSKTLTGDAVENELFKEYKKEFYQEGQLFYYYKRKNKLKIDGYGPEVTSKIYVLPVPDDEIEYVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK69</accession>
    <name>D7VK69_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11388"/>
    <dbReference type="EnsemblBacteria" id="EFK58671">
        <property type="protein sequence ID" value="EFK58671"/>
        <property type="gene ID" value="HMPREF0766_11388"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125018_2_0_10"/>
    <dbReference type="OrthoDB" id="2066470at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018673">
        <property type="entry name" value="DUF2141"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09912">
        <property type="entry name" value="DUF2141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106976" evidence="1">
        <location>
            <begin position="20"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="137" mass="15563" checksum="453464B0AFD9D6C3" modified="2010-10-05" version="1">MKTTIFTAFLLCTSVMARAQQAKLSINVTNVEPGKGTVILNIYDKKEDFLKKVFLSKTLKADDSNLTFVIELPRKGIYAITVFQDKDDNKKLKQDWFGIPQEPVGYGNNFKPSAKPGFKDCSIRVDRDHVIQTIKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKF4</accession>
    <name>D7VKF4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11473</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999206.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11473"/>
    <dbReference type="EnsemblBacteria" id="EFK58756">
        <property type="protein sequence ID" value="EFK58756"/>
        <property type="gene ID" value="HMPREF0766_11473"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022279_1_0_10"/>
    <dbReference type="OrthoDB" id="1384936at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="1">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="227"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="339"/>
            <end position="340"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="371"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="395"/>
            <end position="398"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="473" mass="51486" checksum="9EA449D2F3F8F8AA" modified="2010-10-05" version="1">MTQRINGNDLLALGYKENYSLGTALKINKKRLGLSREEMLNRYKEILGDPESFLSDPIFSPLAQVIIDENNQPADETIPLNEDPKDYKIYGSEQIEDGAKHQMNIAMKLPVTVAGALMPDAHQGYGLPIGGVLAVKNAVIPYGVGVDIGCRMALSVYDIPADKLTENKEIFQKAVLDNSRFGAGQGFLKYQRSEHAVLDNILFDEHPLISTLKDKAWSQLGTSGGGNHFVEFGIIEFKEADKTSGIQAGTYVALLTHSGSRGLGATIAGHYTKIAKELCKLPYSASNLAYLDLNSEAGQEYWLAMHLAGDYASACHEIIHTKMAEALGATVLAKVENHHNFAWKEKWHEEEVIVHRKGATPAGKGVLGIIPGSMAAPGFLVRGKGEQDAINSASHGAGRQMSRTQAIKTLSKKAWKQMLEDHGVTLLGAGMDEAPMAYKNIHTVMEAQTDLIDVLATFSPKIVRMADDGSRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKF9</accession>
    <name>D7VKF9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeoA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">feoA</name>
        <name evidence="3" type="ORF">HMPREF0766_11478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999223.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11478"/>
    <dbReference type="EnsemblBacteria" id="EFK58761">
        <property type="protein sequence ID" value="EFK58761"/>
        <property type="gene ID" value="HMPREF0766_11478"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1918">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150646_12_0_10"/>
    <dbReference type="OrthoDB" id="2047422at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="78" mass="8755" checksum="598B72A2FF81C35C" modified="2010-10-05" version="1">MQHNNSLDKLKKGERAKILSYTSTDIPAKFFEIGFLPGIDIEIKHIAPFNGPICVNILQNNALIALRKSEAKHIIVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKG4</accession>
    <name>D7VKG4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroP</name>
        <name evidence="8" type="ORF">HMPREF0766_11483</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11483"/>
    <dbReference type="EnsemblBacteria" id="EFK58766">
        <property type="protein sequence ID" value="EFK58766"/>
        <property type="gene ID" value="HMPREF0766_11483"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_9_3_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="7">
        <location>
            <begin position="38"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="497" mass="54949" checksum="9B52CFF32DB90AFB" modified="2010-10-05" version="1">MNFWVLEKSVLIIVNNHTAVEENTSEKKELNRGLKNRHIQLIALGGAIGTGLFLGIGPAAVLAGPAVILGYAVAGIIAFFIMRQLGEMVVNEPVSGSFSHFANKYMGPFAGFSSGWNYWFLYILVSMSELTAIGVYVQFWWPEIPLWQSSLFFFIVVNALNLASVKVYGEAEFWFSIIKVLAIVAMIIFGTYLLFSGSGGEQASVTNLWNDGGFFPKGWLSEDGKGGFQGLLAAMALIMFSFGGLELIGITAAEAENPEKNIPRATNQVIYRILIFYVGALIILFSLSPWRNITAGSSPFVMIFENLKGFQFSLFGSTFYFTSIIANALNIIVLTAALSVYNSSVYSNSRMLYGLAKQGNAPRFLLKLNNNHVPIMAILVSAAFAAICIIINKLIPEKALGILMSLVVSALIINWLMISITHLYFKKEKIKEGKKTLFPSFLYPVSNYICLIFLVGILAMMWITGLKISVELIPIWLILLYLGYLIVKKRQANQTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKP7</accession>
    <name>D7VKP7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Outer membrane protein assembly complex, YaeT protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yaeT</name>
        <name evidence="5" type="ORF">HMPREF0766_11566</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999431.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11566"/>
    <dbReference type="EnsemblBacteria" id="EFK58849">
        <property type="protein sequence ID" value="EFK58849"/>
        <property type="gene ID" value="HMPREF0766_11566"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007664_3_0_10"/>
    <dbReference type="OrthoDB" id="258122at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071709">
        <property type="term" value="P:membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010827">
        <property type="entry name" value="BamA/TamA_POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023707">
        <property type="entry name" value="OM_assembly_BamA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07244">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006076">
        <property type="entry name" value="OM_assembly_OMP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03303">
        <property type="entry name" value="OM_YaeT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107341" evidence="3">
        <location>
            <begin position="22"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="4">
        <location>
            <begin position="45"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="4">
        <location>
            <begin position="292"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="4">
        <location>
            <begin position="379"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="858" mass="97426" checksum="B5BE751D8E6EB850" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKP8</accession>
    <name>D7VKP8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ompH</name>
        <name evidence="4" type="ORF">HMPREF0766_11567</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Skp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999432.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11567"/>
    <dbReference type="EnsemblBacteria" id="EFK58850">
        <property type="protein sequence ID" value="EFK58850"/>
        <property type="gene ID" value="HMPREF0766_11567"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053320_0_1_10"/>
    <dbReference type="OrthoDB" id="1854604at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.910.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005632">
        <property type="entry name" value="Chaperone_Skp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024930">
        <property type="entry name" value="Skp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35089">
        <property type="entry name" value="PTHR35089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03938">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00935">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111384">
        <property type="entry name" value="SSF111384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106990" evidence="3">
        <location>
            <begin position="21"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="177" mass="20634" checksum="D278A4609D1B79C7" modified="2010-10-05" version="1">MKKIIAIIAFLTLATTATFAQRFAYVDSEYILKHIPEYVSAQKQLDDLSVQWQEQVDAKYGEIEKLYKAYQNDQVLLNEDMRRRREDEIVKKEKEAKEFQRQKFGYEGELYQQRIRLIKPIQDRVAKAIQDLASNQGLDIILDKGNEVTFLYANPKLDKSNEVITKLGFKPDAALVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKW6</accession>
    <name>D7VKW6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11635"/>
    <dbReference type="EnsemblBacteria" id="EFK58239">
        <property type="protein sequence ID" value="EFK58239"/>
        <property type="gene ID" value="HMPREF0766_11635"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1133028_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107628" evidence="1">
        <location>
            <begin position="20"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="236" mass="27093" checksum="A3A383D8A6E411C0" modified="2010-10-05" version="1">MKRYFILIMLASLLSSVKAQVQQIEDFKDLYMPDPETFLTGFIPAGFTRISHIEALDVIDTFFMERSGKRAIFGFTSDQVNYYKKGNIVMSCKVYNDSIKWHIQQNIRVQEMEGSPGTTQPASPTKKYWNPYNGFKGTGAYLVEGYVLDAFGLLDLEGKIWPGMTSEKRTNNTLEVGYAYPTISPMRLYPVLVAFDKGYRYKVEVRIYTVNSNRQEAVDNLKWIAEHMEIGIDLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL11</accession>
    <name>D7VL11_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphodiester phosphodiesterase family protein</fullName>
            <ecNumber evidence="3">3.1.4.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glpQ4</name>
        <name evidence="3" type="ORF">HMPREF0766_11680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.46" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999706.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11680"/>
    <dbReference type="EnsemblBacteria" id="EFK58284">
        <property type="protein sequence ID" value="EFK58284"/>
        <property type="gene ID" value="HMPREF0766_11680"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_3_5_10"/>
    <dbReference type="OrthoDB" id="1542724at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107265" evidence="1">
        <location>
            <begin position="20"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="23"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="256" mass="28897" checksum="8968044513361A08" modified="2010-10-05" version="1">MKNLVLSLLILGASISAVSAQKNPIIAHRGAWKNTNLPQNSLASLDAAITEGVFGSEFDVHLTKDDVLVVNHDNDFYGLDIATSTYDELLKKKHPNGESIPTAEEYLKEGLKQKKTKLIYELKTNKLGLDRTLLAAQKSVELVKKLKGEKMVEYIAFDYNACKKFVELNPKAKVHYLMGDKSPQELKNDKMTGADYHFSVYKKNPTWIKELQNLGLKVNAWTVNTEEEMQILLDQKVDYLTTDNPELLAELLKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL28</accession>
    <name>D7VL28_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibronectin type III domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999739.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11697"/>
    <dbReference type="EnsemblBacteria" id="EFK58301">
        <property type="protein sequence ID" value="EFK58301"/>
        <property type="gene ID" value="HMPREF0766_11697"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_240559_0_0_10"/>
    <dbReference type="OrthoDB" id="558757at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026341">
        <property type="entry name" value="Bac_Flav_CTERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04131">
        <property type="entry name" value="Bac_Flav_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107269" evidence="1">
        <location>
            <begin position="26"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="471"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="574"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1711" mass="188630" checksum="B29977A037E9C1F9" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLC5</accession>
    <name>D7VLC5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CobQ/CobB/MinD/ParA nucleotide binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">soj</name>
        <name evidence="2" type="ORF">HMPREF0766_11794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999997.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11794"/>
    <dbReference type="EnsemblBacteria" id="EFK58398">
        <property type="protein sequence ID" value="EFK58398"/>
        <property type="gene ID" value="HMPREF0766_11794"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_1_4_10"/>
    <dbReference type="OrthoDB" id="729012at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="2"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="265" mass="29185" checksum="8520C3A3A3ADE160" modified="2010-10-05" version="1">MGKIIAIANQKGGVGKTTTSINLAASLAVLEYKTLLVDADPQANSTSGIGFDPRGIKASVYECLVNDLSAREAIQTTETPNLDLLPAHIDLVGAEIEMINMHEREYKMKKILDEVKDDYDFIIIDCSPSLGLITINALTGSDSVIIPVQCEYFALEGLGKLLNTIKIVQNRLNTNLEIEGILLTMYDVRLRLSNQVVEEVRTHFNDLVFSTIIQRNTRLSEAPSFGISVIMHDASCKGAINYLNLAREILEKNGMVKEEKQTVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLI2</accession>
    <name>D7VLI2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">asd</name>
        <name evidence="14" type="ORF">HMPREF0766_11852</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000149.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11852"/>
    <dbReference type="EnsemblBacteria" id="EFK58455">
        <property type="protein sequence ID" value="EFK58455"/>
        <property type="gene ID" value="HMPREF0766_11852"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049966_0_1_10"/>
    <dbReference type="OrthoDB" id="1799040at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="37"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFK58455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="329" mass="35905" checksum="082AD0D5B1081291" modified="2010-10-05" version="1">MKVAVVGATGLVGSEMLTVLAERNFPVTTLIPVASEKSKGKEIEFKGKKYAVVTATEAIALKPDVALFSAGGSTSTEFAPLFAEAGITVIDNSSAWRMDPTKKLVVPEVNGDVLTAEDKIIANPNCSTIQMVVALKPLHDKYKIKRVVVSTYQSVTGTGVKAVQQLNDERAGIEGEKAYPYQIDLNVIPHIDVFQDNGYTKEEMKMIKETNKIMQDDSIKVTATTVRIPVMGGHSESLNIEFENEFDLKDIRSVLEAQSGVIVVDDPANLAYPMPKDAHGRDEVFVGRIRRDESQDKTLNMWVVADNLRKGAATNAVQIAELLNKKGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLL7</accession>
    <name>D7VLL7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11887"/>
    <dbReference type="EnsemblBacteria" id="EFK58490">
        <property type="protein sequence ID" value="EFK58490"/>
        <property type="gene ID" value="HMPREF0766_11887"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_214511_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="52" mass="6430" checksum="01CDD5E38372927A" modified="2010-10-05" version="1">MFGLYFVLGLLIIFWNNFPLEINPTYRTFFGILLIVYSFMRFARLWQNNFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLN1</accession>
    <name>D7VLN1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000258.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11901"/>
    <dbReference type="EnsemblBacteria" id="EFK58504">
        <property type="protein sequence ID" value="EFK58504"/>
        <property type="gene ID" value="HMPREF0766_11901"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083272_1_0_10"/>
    <dbReference type="OrthoDB" id="1953878at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107081" evidence="2">
        <location>
            <begin position="24"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="278" mass="33304" checksum="4DDC633D4E1ABB4A" modified="2010-10-05" version="1">MATNFRTIILSIFFITISYLSYAQEQDTLYTDPDTATYDEPIDAAEELITKKKQHPYWEEGYYNKVPRIHDIPAVDTAEFNKMFKKYQSEEFLYNEKVLENINFLKRLKNRINDLLSSILPDFYFENPEWMYKLIGAVFVVLLVYVLYRLIFTGKKLYTVQEKEDDEDANVAFVERNLLQVDVHTFVEQALKEENYSLAIRYLNLLNIQTLAKKELVKWNYTKTNIELMNEMDNTELRKEFEACSNVFNYVWFGNFPVTKDNYEQYATLFREFQTKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLP7</accession>
    <name>D7VLP7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA polymerase I</fullName>
            <ecNumber evidence="2 11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 15" type="primary">polA</name>
        <name evidence="15" type="ORF">HMPREF0766_11917</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2 11"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000290.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11917"/>
    <dbReference type="EnsemblBacteria" id="EFK58520">
        <property type="protein sequence ID" value="EFK58520"/>
        <property type="gene ID" value="HMPREF0766_11917"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0749">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004675_0_0_10"/>
    <dbReference type="OrthoDB" id="1220182at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018320">
        <property type="entry name" value="DNA_polymerase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00593">
        <property type="entry name" value="pola"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11 15" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 11 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="53EXOc" evidence="13">
        <location>
            <begin position="2"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="3'-5' exonuclease" evidence="12">
        <location>
            <begin position="337"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="POLAc" evidence="14">
        <location>
            <begin position="687"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFK58520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="930" mass="103885" checksum="4622A07B90608282" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLQ7</accession>
    <name>D7VLQ7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ycbL</name>
        <name evidence="2" type="ORF">HMPREF0766_11927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000311.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11927"/>
    <dbReference type="EnsemblBacteria" id="EFK58530">
        <property type="protein sequence ID" value="EFK58530"/>
        <property type="gene ID" value="HMPREF0766_11927"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_5_3_10"/>
    <dbReference type="OrthoDB" id="1581636at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="13"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="213" mass="24091" checksum="F576B0BBB9D7EA97" modified="2010-10-05" version="1">MVHLKQFVCNPYQENTYVLYDDKGFCAIIDPGMYGKAEEDLFLSFIEEHKLNPVVLLNTHCHIDHVLGNKFIHEHFGLLPQFHEGELPLLIEVQNYAPQMGIRYDISPIGEYFLPEEGTVSFGDNVLKLIFVPGHSPAHLCFYHESQKFVIGGDALFRGSIGRTDLPGGNHNQLLKSIQEKLYTLPEDVIVYPGHGPSTTIGDEKRTNPFIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLT5</accession>
    <name>D7VLT5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001581.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12189"/>
    <dbReference type="EnsemblBacteria" id="EFK58197">
        <property type="protein sequence ID" value="EFK58197"/>
        <property type="gene ID" value="HMPREF0766_12189"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1516998_0_0_10"/>
    <dbReference type="OrthoDB" id="1840536at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="177" mass="20080" checksum="DBE0FC1F851A6419" modified="2010-10-05" version="1">MWNKLSYHKKNKLLYTVAAVVFVICWIFAFSKTWDAYSLNNRLEQQIGTGTDNSKGSKNMIVKSRVLDSLVSRYRKDSLQWNDNFIMNASKGMTDPAINLSYNNASSGKRSNDADTLALRKTIMVSGTYKGLVQQIQALEALPELGLLSRVILKTKDSRYDQDAATIQTELEFRVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLY1</accession>
    <name>D7VLY1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar isomerase, KpsF/GutQ family</fullName>
            <ecNumber evidence="6">5.3.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">kdsD</name>
        <name evidence="6" type="ORF">HMPREF0766_11978</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SIS family. GutQ/KpsF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.13" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK57986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001098.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11978"/>
    <dbReference type="EnsemblBacteria" id="EFK57986">
        <property type="protein sequence ID" value="EFK57986"/>
        <property type="gene ID" value="HMPREF0766_11978"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0794">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_13_1_10"/>
    <dbReference type="OrthoDB" id="571638at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019146">
        <property type="term" value="F:arabinose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05014">
        <property type="entry name" value="SIS_Kpsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004800">
        <property type="entry name" value="KdsD/KpsF-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035474">
        <property type="entry name" value="SIS_Kpsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004692">
        <property type="entry name" value="KdsD_KpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00393">
        <property type="entry name" value="kpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SIS" evidence="5">
        <location>
            <begin position="36"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004692-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR004692-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK57986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="321" mass="34604" checksum="26AC04D58CB74BE5" modified="2010-10-05" version="1">MKNNTQIKNIAIEAIALEAQSVQNLTNNINDDFVGVVHEILNLKGRVIVTGIGKSAIIAQKIVATLNSTGTPSIFLHAADAIHGDLGIVQPQDLIIALSKSGNTPEIKVLVPFLKQTQNKLVAIVGNTGSFLAQHADYILDTTVEREACPNNLAPTTSTTAQLAMGDALAVVLQECREFSDRDFAKYHPGGALGKQLYLKVSDLSDQNGKPEVSPEASVRQIIITITQFRLGATAVIDQGTILGIITDGDIRRMLETHDDLSHITAKDIMGKSPKLIDKNELAVNALHQMKDNNITQLLATENGKYAGIIHIQDLLKEGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM51</accession>
    <name>D7VM51_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aromatic ring-opening dioxygenase, catalytic subunit LigB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ygiD</name>
        <name evidence="6" type="ORF">HMPREF0766_12048</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001303.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12048"/>
    <dbReference type="EnsemblBacteria" id="EFK58056">
        <property type="protein sequence ID" value="EFK58056"/>
        <property type="gene ID" value="HMPREF0766_12048"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3384">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046582_2_0_10"/>
    <dbReference type="OrthoDB" id="1728007at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016701">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LigB" evidence="5">
        <location>
            <begin position="26"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="276" mass="31260" checksum="8BB45DF29A627ABE" modified="2010-10-05" version="1">MISGLKDLKNLSDSLRTQSKLMPVLFVGHGSPMNGIEDNEFSGNWSNMAKEIPQPQAVLVISAHWYTDSTKVTAMEKPKTIHDFYGFPKELFAVTYPAPGSPKLAMETKSLISHTQVELDHDWGLDHGTWTVVRYMYPDAQIPVLQLSIDYRQHPSWHYELGKELLALRKKGVLIIGSGNMVHNLRMVSWDMIHGGGYDWAYQMNDTFKKLIESKEHQKLIRYDELGSGAMLAIPTPEHYLPMLYSLSLQQSNEDVSFFNDKLVGGSLNMTSLKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM73</accession>
    <name>D7VM73_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">smc</name>
        <name evidence="5" type="ORF">HMPREF0766_12070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001355.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12070"/>
    <dbReference type="EnsemblBacteria" id="EFK58078">
        <property type="protein sequence ID" value="EFK58078"/>
        <property type="gene ID" value="HMPREF0766_12070"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_2_2_10"/>
    <dbReference type="OrthoDB" id="1149850at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02168">
        <property type="entry name" value="SMC_prok_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="4">
        <location>
            <begin position="520"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="297"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="676"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="835"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1180" mass="135765" checksum="8FE9CFAF454A41EA" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM78</accession>
    <name>D7VM78_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Drug resistance transporter, Bcr/CflA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tcaB</name>
        <name evidence="9" type="ORF">HMPREF0766_12075</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Bcr/CmlA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001360.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12075"/>
    <dbReference type="EnsemblBacteria" id="EFK58083">
        <property type="protein sequence ID" value="EFK58083"/>
        <property type="gene ID" value="HMPREF0766_12075"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_47_0_10"/>
    <dbReference type="OrthoDB" id="1452500at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004812">
        <property type="entry name" value="Efflux_drug-R_Bcr/CmlA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00710">
        <property type="entry name" value="efflux_Bcr_CflA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="12"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK58083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="401" mass="43565" checksum="383B432F41E4906C" modified="2010-10-05" version="1">MHNFSKFKRSTIIFILGLLSAIGPFSIDMYLPAFKTIATDFGTSVDRVQLSLSSFFIGIAIGQLVYGPLLDKFGRKKPLIVGISLYIFASIMCIFSTNIEQLIVFRFIQALGSCSGMVASRAMVRDYFGPQESAKIFSMLMLIVGISPILAPSVGAFVMSHFEWHMIFTILTVMAVLILISVIFLLPESFAGNKNFSLAPKQVTINFWTVCKNPQFLSFCLVSALTASALYAYLAGSPFVMQELYGLTESEYGIVFAIIASALILATQINRIALNRWSSSDISRFASRLQVSMSALFIVVTLGGWITLPTMVGFIFLILLAQGFIFPNTSALALAPFKELAGSASALLGCFQMGIGALASGAVSILHNNTALPMVIVMSACSFLGLIIYLYLPKLLKPATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VML1</accession>
    <name>D7VML1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DEAD/DEAH box helicase</fullName>
            <ecNumber evidence="11">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rhlE</name>
        <name evidence="11" type="ORF">HMPREF0766_12231</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="11"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992661.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12231"/>
    <dbReference type="EnsemblBacteria" id="EFK57158">
        <property type="protein sequence ID" value="EFK57158"/>
        <property type="gene ID" value="HMPREF0766_12231"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_28_1_10"/>
    <dbReference type="OrthoDB" id="643629at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="34"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="232"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="412"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK57158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="450" mass="50709" checksum="F5A9393DEADB0541" modified="2010-10-05" version="1">MQNSFEDFKFNKQILNAISEAGYSVPTEIQQKAITPVLAGQDIMGIAQTGTGKTAAFVLPMLMKLKYAQGKDMRALILSPTRELAMQIEEHIQLFSKYLDLRTVVLYGGLGPKTQIENLEKGVDIIVATPGRFLDLYLEGHINVKSLKFLVMDEADKMMDMGFISKIHRILEVVPRKRQNLLFSATMSELVRKIAGDFLAFPTVIEVTEQATPAKTVQQAVYKVPNQKTKLNLLQHLLKDDESFHRLIVFCKTKTVADNVFHFLERKYGTEQVRVIHANKGQNTRINSINAFKEGNIRILVATDVAARGLDVSNVSHVINFEVPIVIEDYVHRIGRTGRAFNEGDAITFSNPAEDYYVRKIEKLIRQSIPVLEIPEEVFVEKTGFEERQAIAREIDNQKKKDDPDFKGAFHEKKYMLNGGGKPKPVKKTGAKKTTATGKKKKGKAFKPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMS0</accession>
    <name>D7VMS0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ACR, COG1399</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992761.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12290"/>
    <dbReference type="EnsemblBacteria" id="EFK57217">
        <property type="protein sequence ID" value="EFK57217"/>
        <property type="gene ID" value="HMPREF0766_12290"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094155_0_0_10"/>
    <dbReference type="OrthoDB" id="1665714at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="178" mass="20905" checksum="38D879B6E5464AF9" modified="2010-10-05" version="1">MKYLKQYRIPFSGLNAGKHSFDFDIEKKFFDCFEHSIVKDGNLKAQVDLQKQENMLIVHFTITGTIKLTCDVCLSEFDYPIDVKERILVKFTDENWEEDTEEVIVLSKNDYEFDIAHLLYEYINVAVPYYTKCSEQGLNQSCDPEMLAKVNQTEEEEENSAEEHIDPRWSALRNIKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMV8</accession>
    <name>D7VMV8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Formyltetrahydrofolate deformylase</fullName>
            <ecNumber evidence="3">3.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Formyl-FH(4) hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purU</name>
        <name evidence="5" type="ORF">HMPREF0766_12328</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="EC" id="3.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PurU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.10" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992832.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12328"/>
    <dbReference type="EnsemblBacteria" id="EFK57255">
        <property type="protein sequence ID" value="EFK57255"/>
        <property type="gene ID" value="HMPREF0766_12328"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0788">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038395_3_0_10"/>
    <dbReference type="OrthoDB" id="979667at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04875">
        <property type="entry name" value="ACT_F4HF-DF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01927">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044074">
        <property type="entry name" value="PurU_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="PTHR42706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00655">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="4">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="280" mass="32307" checksum="A040FEE19B75AA29" modified="2010-10-05" version="1">MTKPILILIQCQDDVGLVAKIANALAQYRLNIVTMREFVDEEAGKFFVRVVCTGKLENTEELFSALQQSLPDNASIKINPSERKKIIILVTKEHHCLADILIRHHFETWDTDIQAVIGNYSDLEGFTRKFDIPYHYVSHENLSKEEFEDRLTAQIDQYEFDYIILAKFMRILSPTFVQQYQGRIINIHHSFLPAFIGANPYRQAHTRGVKIIGATAHYVTDDLDEGPIIVQDTRRVNHTYTVQDMMTAGKEIEKAVLARAIRLLLEDRVMLDRNKTVVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN24</accession>
    <name>D7VN24_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992924.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12394"/>
    <dbReference type="EnsemblBacteria" id="EFK57321">
        <property type="protein sequence ID" value="EFK57321"/>
        <property type="gene ID" value="HMPREF0766_12394"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2511007_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="85" mass="10042" checksum="758368C15F0407BE" modified="2010-10-05" version="1">MEAITKPTWPQSWREKMDRMEIGESEPVDQRVVKSVRYIASKHFHSAKARSKKRFTVKKDPMHPGKYKLWRKEDDALKEGGLNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN44</accession>
    <name>D7VN44_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992951.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57341">
        <property type="protein sequence ID" value="EFK57341"/>
        <property type="gene ID" value="HMPREF0766_12414"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZSVT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1460402_0_0_10"/>
    <dbReference type="OrthoDB" id="2177102at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="185" mass="22147" checksum="D909E774C0BAE0A7" modified="2010-10-05" version="1">MDWIDLVEVKHIMNIPLKEGDSFFKKQLYSYKFPRKPKAKTIIEVEHYEGNIIVISFYKDGAGTDKNRYKLRHNYPSILVLRILQSCLKIFLELNSDNSYTLVFNASDDVDDYKAFNHRMSSYTKFLEIYYPNYEEHCFYSGYMNLNTFYCHHKDNPNHEIARSFFEEYCEKVKAQFNNSEESSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNC3</accession>
    <name>D7VNC3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993051.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12493"/>
    <dbReference type="EnsemblBacteria" id="EFK57420">
        <property type="protein sequence ID" value="EFK57420"/>
        <property type="gene ID" value="HMPREF0766_12493"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091689_0_0_10"/>
    <dbReference type="OrthoDB" id="1437267at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="217" mass="24391" checksum="7B3704D18D232AF7" modified="2010-10-05" version="1">MSINLQKITLEKKGDTHAIDLSKRGDTLSKEITVNLNWSKGSKKGFFSGLFNKDIDLDLGCFYELNNGEKAVIDGLQFSQGRGGARDRYTLQGRYTDTPWIWHAGDDRGQSAGSGENILINPKGVADIKRIVIYCFIYDGVARWQETNAVVTIKVPGNPDIEVQMGQQHSYHKFCAIAEINFHPNSMQVKKLITFHDSHGDCDKAYRWGMKWTSGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNS0</accession>
    <name>D7VNS0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Copper-exporting ATPase</fullName>
            <ecNumber evidence="8">3.6.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">actP</name>
        <name evidence="8" type="ORF">HMPREF0766_12640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.4" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993255.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12640"/>
    <dbReference type="EnsemblBacteria" id="EFK57567">
        <property type="protein sequence ID" value="EFK57567"/>
        <property type="gene ID" value="HMPREF0766_12640"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_3_10"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00941">
        <property type="entry name" value="CDATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="750"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="775"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="7">
        <location>
            <begin position="7"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="7">
        <location>
            <begin position="74"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK57567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="803" mass="86675" checksum="ADB1D414BB235343" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNX0</accession>
    <name>D7VNX0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Urease subunit beta</fullName>
            <ecNumber evidence="2">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Urea amidohydrolase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">ureB</name>
        <name evidence="3" type="ORF">HMPREF0766_12690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the urease beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993335.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12690"/>
    <dbReference type="EnsemblBacteria" id="EFK57617">
        <property type="protein sequence ID" value="EFK57617"/>
        <property type="gene ID" value="HMPREF0766_12690"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129707_1_1_10"/>
    <dbReference type="OrthoDB" id="1755809at2"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01954">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="SSF51278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="123" mass="13661" checksum="B648A365425EBCBF" modified="2010-10-05" version="1">MVPGEYFLKAGDIKANAGYKTIHVVVANTGDRPIQIGSHYHFFEVNKALQFDREKAFGMRLNIPASTAVRFEPGEKKEVILVEIGGDKEIHGFNGLTNGKYTSEKVKSAAISKMKKQQFKSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNX9</accession>
    <name>D7VNX9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993349.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12699"/>
    <dbReference type="EnsemblBacteria" id="EFK57626">
        <property type="protein sequence ID" value="EFK57626"/>
        <property type="gene ID" value="HMPREF0766_12699"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_13_3_10"/>
    <dbReference type="OrthoDB" id="1473468at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="55"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="339" mass="39024" checksum="FD1E4EEAC1269907" modified="2010-10-05" version="1">MTTRRKTAWHRVSSFILLTLIIACSNPGEKKQTAEKISAVDARGKEITLETYAQRVVVLFEPFVDQIYMLNAGDRLVGIPQQIYQNPSTYHFLSLLDKRIARKQIVTPTFGGRSTHVETLVALEADLAIVYEHDKETIAQLEDLHIPVYVVSSRDKDHIYNELVGVGTLLGREQRAEAIVGYVEQEVEKMKLHEDIKRKKVYYAWSKGRVFSTSCRGSLVDLSMQVSGAENACPLTLEAPNISAESLYKWNPDLIVLWNSKLQDVYSLKELEAVPAVIDKQVYNMEPTFYYDPHTVKFLLFAKQLRQWCYPTYSEQQFKTELQQTLAFLYSKKIWEDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP16</accession>
    <name>D7VP16_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5109 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993421.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12736"/>
    <dbReference type="EnsemblBacteria" id="EFK57663">
        <property type="protein sequence ID" value="EFK57663"/>
        <property type="gene ID" value="HMPREF0766_12736"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7X1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068229_0_0_10"/>
    <dbReference type="OrthoDB" id="1035032at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027849">
        <property type="entry name" value="DUF4434"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033402">
        <property type="entry name" value="DUF5109"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14488">
        <property type="entry name" value="DUF4434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17134">
        <property type="entry name" value="DUF5109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5109" evidence="1">
        <location>
            <begin position="190"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="312" mass="36023" checksum="082AD0356945D3AA" modified="2010-10-05" version="1">MKITGTFIDEISHDIPHQNWGAEEWDRDFAYMKALGIDTVIMIRSGYRNFITYPSEYLMSKHGCYRPSMDLVELYLTLADKYDMKFYLGLYDSGVYWDTGNLQFEIDANRFVIDEVWQKYGHYKSFGGWYISTEISRRTKGATEAFYTLGKQCKDVSNGLPTFISPWIDGKKAVMASSASLSKEDAVSVKEHEQEWGEIFDGISGAIDAVAFQDGHIDYHELPAFFEINKKLADRYGLECWTNAESFDRDMPIKFLPIKFDKLRLKLEAAHAAGYDKAITFEFSHFMSPQSAYLQAGHLYNRYKEYINTLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP19</accession>
    <name>D7VP19_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YARHG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12739"/>
    <dbReference type="EnsemblBacteria" id="EFK57666">
        <property type="protein sequence ID" value="EFK57666"/>
        <property type="gene ID" value="HMPREF0766_12739"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZAP3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_705559_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025582">
        <property type="entry name" value="YARHG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038434">
        <property type="entry name" value="YARHG_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13308">
        <property type="entry name" value="YARHG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01324">
        <property type="entry name" value="YARHG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107183" description="YARHG domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="YARHG" evidence="2">
        <location>
            <begin position="298"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="376" mass="43820" checksum="9EA84042AA200736" modified="2010-10-05" version="1">MIVKYAILMKNFLLILSLLLCFTAYSYANDGAFFARGNQLVPIHETDISVRKEILTIRKVGDRQVHITVYYEFENPVEDKKITVGFEAMSPSGDVDGTPKNGFHPYMRDFTVKLNNQDLPYKVAYVYDSLYVNNGKIVSEPLDKIKKEIDNVNEVGFNYVYYFEAPFRKGKNSIQHTYTYDLSGSIDYQYYLEYVLTAARRWANKQIDDFTLIVDMGDVTEFNIHKTFFDKKEDWQIKGWGKTKEVEALPSSVHESDQIRFTIRQGTLVFHKTNFAPAGELYLSAENYFPPGESFDSKTDVLPFAVYAQDRILKAKDETSKKILRNLPFARRGYVFKSKDLRDYYSNIDWYAADPKYIPKPKDLTPEEQKWLKELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPU5</accession>
    <name>D7VPU5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993905.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13015"/>
    <dbReference type="EnsemblBacteria" id="EFK57942">
        <property type="protein sequence ID" value="EFK57942"/>
        <property type="gene ID" value="HMPREF0766_13015"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_9_2_10"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="20"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="177" mass="20967" checksum="D3DDDFB2B89E9113" modified="2010-10-05" version="1">MKVDNIANKLKHANLFDKTVTLRRHEFLCTKDSIDQHIYWIDSGSLRIFMMDGEEERNIRFGYSDNLIVSLDSFLSGKPTDFYIQAIRKTTVRIANKSSLQQFIQSAPDKLILWNQILEDLILQQVEREKDILISSPRERYERIQKRSPRLFQEIPNKYIANYLRMSPETLSRLQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPY2</accession>
    <name>D7VPY2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993944.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13036"/>
    <dbReference type="EnsemblBacteria" id="EFK55833">
        <property type="protein sequence ID" value="EFK55833"/>
        <property type="gene ID" value="HMPREF0766_13036"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041408_4_2_10"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="220"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK55833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="328" mass="38317" checksum="6264C6E4A2CCCD1A" modified="2010-10-05" version="1">MQIDRILPDRIFNALTLLIGLLTLLHLAALFLNIGIPFSLLYGPILYLIQQTFYKKYMRIRQMLIHLIPFILCTVWIYSADTSPILFYSYSLINTLMVCTSSMGYTVMILLNMKKWTSHPENIKVSLFIKSFFIFCAIEFGFLTLVLHHRLQFDYDIDPMIIICLLSVLSALLSFDFLIRRLSSSFEQTNAAGRKLSIAQLPFLEEIRMDEAHWELYRQDLVRSVEEQQLYLDTGLSADRLADEIGISRQQLSVLLNNYLGKNFYEWIAEYRIAHAVKLFREGGYILKIESLAFQCGFNSKTTFNKYFKHYMGITPSEFREHLSLNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ51</accession>
    <name>D7VQ51_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RNA polymerase sigma-54 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rpoN</name>
        <name evidence="12" type="ORF">HMPREF0766_13105</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-54 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994045.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13105"/>
    <dbReference type="EnsemblBacteria" id="EFK55902">
        <property type="protein sequence ID" value="EFK55902"/>
        <property type="gene ID" value="HMPREF0766_13105"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020569_0_1_10"/>
    <dbReference type="OrthoDB" id="1906842at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000394">
        <property type="entry name" value="RNA_pol_sigma_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007046">
        <property type="entry name" value="RNA_pol_sigma_54_core-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007634">
        <property type="entry name" value="RNA_pol_sigma_54_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038709">
        <property type="entry name" value="RpoN_core-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32248">
        <property type="entry name" value="PTHR32248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00309">
        <property type="entry name" value="Sigma54_AID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04963">
        <property type="entry name" value="Sigma54_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04552">
        <property type="entry name" value="Sigma54_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000774">
        <property type="entry name" value="RpoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00045">
        <property type="entry name" value="SIGMA54FCT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02395">
        <property type="entry name" value="rpoN_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00718">
        <property type="entry name" value="SIGMA54_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sigma54_CBD" evidence="11">
        <location>
            <begin position="115"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma54_DBD" evidence="10">
        <location>
            <begin position="327"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="41"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK55902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="487" mass="56127" checksum="257CCED7E8941CCE" modified="2010-10-05" version="1">MLKQTLQQKLLQKLSPQQIQFIKLLQVPTVSLDARIKEELEENPALEDGSLINMNEPVQEYPDKDPDEQYEGEDNSFDEEFSVDEYIQDDDFNDYGNSYGGDDEEDRKEMPIAIQSSFFESLQNQLDLLALDDKNFLIGQQIIGSLDDDGYLRRPILSLIDDLAFSQNVIAEEEEVLEMLKIVQDFEPAGIGARDLQECLLIQLKKKNNDNEAVKKAIIVVQNYLEEFTKKHYDKLEKALGLNSEELKNIIQEILKLNPKPGDSGAAAGKQLHIIPDFHISNNDGVLHLTLNGRNAPELRVSRSYQEMFEHYEKVEKTDKKMKEAVQFVKQKLDSAKWFIDAIKQRQQTLLKTMNAIMEYQYEYFLTGDDRMLKPMILKDIADRIEMDISTVSRVANSKYVQTEFGTFLLKSFFSEAIQTDSGEEVSNKEVKKILEECISNEDKRKPLADEKLTDILKEKGYSIARRTVAKYREALNIPVARLRKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQA1</accession>
    <name>D7VQA1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proline dehydrogenase</fullName>
            <ecNumber evidence="3">1.5.99.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pdh</name>
        <name evidence="3" type="ORF">HMPREF0766_13155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.99.8" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994124.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13155"/>
    <dbReference type="EnsemblBacteria" id="EFK55952">
        <property type="protein sequence ID" value="EFK55952"/>
        <property type="gene ID" value="HMPREF0766_13155"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018202_3_0_10"/>
    <dbReference type="OrthoDB" id="1746057at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006562">
        <property type="term" value="P:proline catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PTHR13914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pro_dh" evidence="2">
        <location>
            <begin position="82"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK55952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="399" mass="45174" checksum="EDB137B0A4D17B29" modified="2010-10-05" version="1">MSNTAAPGKLSFDNTEIAFKSKSDKDLDRAYWLFKMVASNTLIKIGTPITNFSLNIGLPIQGIIKNTIYKQFCGGETIQGCAPAIRQLGENGVGTILDYSVEGEDTEEVFDYTCEEILRTVAAAKNNPYIPFSVFKPTGLGRFELFEKVNAKKELSDMEKVEYQKMWDRTNRICKACYEADIKVLVDAEHSWIQDVIDDIAREMMELYNKEKPIVYNTYQLYRHDKLASLKADFAYARTQGFYLGAKTVRGAYMEIERERAAQKGYPSPIQPTKEASDIDYNKAILFCLDNIEQIGLMAGTHNEASSLLLAEEMNKRNISHQHPHIFFAQLLGMSDNLTFNLAAAGYNVAKYMPYGPVKAVMPYLFRRAQENTSVGGQTGRELSLIIKEKERRKSSRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQB0</accession>
    <name>D7VQB0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994150.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13164"/>
    <dbReference type="EnsemblBacteria" id="EFK55961">
        <property type="protein sequence ID" value="EFK55961"/>
        <property type="gene ID" value="HMPREF0766_13164"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030WXF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_833948_0_0_10"/>
    <dbReference type="OrthoDB" id="1027801at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="333" mass="37144" checksum="964DD889F079D23C" modified="2010-10-05" version="1">MKRIFVFALTICLAGQTYAQKRTRDFLLMSPSEKVETSLYNAIDVIDNRDFKENLGIIQVGLLNSKAQVIPEIPLEKQIQQQLGFLVSGEKSDGALTLVIQKFAVAELTGAFSESGFFDFRASLFVKNKDKSYQRLATIDTAHINNGMDVTKGLLRHASYIVSHFLKDNLGKSPTDTIRYSQSQVLDFENIEKSKVTLYSNGIVNDGVYYDYLHFRDQLPQANVSLLNNDLTKGFYSPDSNGKLKRLKANRCYAVVVDGLAYISSEGTFYPLYKNDKDYFFNGLSRTTASASNVIAASVLFGALGAALAANNTEYYVTKIDFYNGSFIKVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQF4</accession>
    <name>D7VQF4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thiamine-phosphate synthase</fullName>
            <shortName evidence="8">TP synthase</shortName>
            <shortName evidence="8">TPS</shortName>
            <ecNumber evidence="8">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="8">TMP pyrophosphorylase</shortName>
            <shortName evidence="8">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">thiE</name>
        <name evidence="12" type="ORF">HMPREF0766_13208</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 8 9">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8 9">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 8 10">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994253.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13208"/>
    <dbReference type="EnsemblBacteria" id="EFK56005">
        <property type="protein sequence ID" value="EFK56005"/>
        <property type="gene ID" value="HMPREF0766_13208"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018272_3_2_10"/>
    <dbReference type="OrthoDB" id="1558094at2"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TMP-TENI" evidence="11">
        <location>
            <begin position="11"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="8">
        <location>
            <begin position="41"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="138"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="189"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFK56005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="212" mass="23164" checksum="BF7BAEAA29097F23" modified="2010-10-05" version="1">MQIHPGFPYPLYLVISEADCQGKDILYVAEQAILGGVDIIQLREKHASTSEFIEKALRLKEITEKHQIPLIINDNLKVAIEVNAFGIHVGNSDTPPTVIRDKWPDCSCLGYSIEYLEQLDNPETATADYLGISPVFVTDTKTDTVTEWGLAGIQQIRMHSDKPLIAIGHMNLQNIASVLQAGADAIAVVSAICAAADPQQAAYELKNKILIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQG9</accession>
    <name>D7VQG9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994281.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13223"/>
    <dbReference type="EnsemblBacteria" id="EFK56020">
        <property type="protein sequence ID" value="EFK56020"/>
        <property type="gene ID" value="HMPREF0766_13223"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_0_4_10"/>
    <dbReference type="OrthoDB" id="537440at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="532" mass="60413" checksum="10970A7DC2819206" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQK0</accession>
    <name>D7VQK0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994351.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13254"/>
    <dbReference type="EnsemblBacteria" id="EFK56051">
        <property type="protein sequence ID" value="EFK56051"/>
        <property type="gene ID" value="HMPREF0766_13254"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZFBI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2604275_0_0_10"/>
    <dbReference type="OrthoDB" id="2223170at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="79" mass="9069" checksum="964AEFFB755DDB74" modified="2010-10-05" version="1">MLLKNLRDLSIKRLMERRNLVKGILIGAVIVWFFMIGMAFYVYMNISSLKLFIPAAVLPVTFIPMINALKVLNAEIKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQM0</accession>
    <name>D7VQM0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter, SSS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sglT</name>
        <name evidence="8" type="ORF">HMPREF0766_13274</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994384.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13274"/>
    <dbReference type="EnsemblBacteria" id="EFK56071">
        <property type="protein sequence ID" value="EFK56071"/>
        <property type="gene ID" value="HMPREF0766_13274"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018808_9_3_10"/>
    <dbReference type="OrthoDB" id="231452at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00456">
        <property type="entry name" value="NA_SOLUT_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK56071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="521" mass="58265" checksum="80C92809D20717D4" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR43</accession>
    <name>D7VR43_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, GntR family</fullName>
            <ecNumber evidence="3">2.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994610.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13447"/>
    <dbReference type="EnsemblBacteria" id="EFK56244">
        <property type="protein sequence ID" value="EFK56244"/>
        <property type="gene ID" value="HMPREF0766_13447"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_0_10"/>
    <dbReference type="OrthoDB" id="1024978at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="476" mass="52915" checksum="908A46C2D601A551" modified="2010-10-05" version="1">MAKEFLYNEIASALAQQIKNGVLKSGDRLPSVRRLCAEHDISMNTAKRVYLELEGQSLIDSRPQSGYFVSHIPFLRLPIPEVSQPLAIANSNEPDQLISKVYSSMGNDELTLLSIAVPDRALLPLAKLKKEIIHASRELQGGGTEYEVLQGNIKLRRMIAVRSLTWGGNLNENDLITTNGGMNSLSFCLMALGKPGDTIAIESPCYPGILQLAVELGYKVLELPTHPITGIEIEALKEAIPKIDICLLIPNFNTPLGSCMSDENKREVVRLLAKHQIPLIEDDVYGDLYFGAQRPKCCKSFDTEGNVLWCSSISKTLAPGYRVGWIAPGKYKEKLLKLKLVHSISSTSVVQEAVGNFLKTGRYENHLRNLRRTLQDNYQKYIQAIAAYFPEGTKTSRPQGGLALWIEFPKGIDTALLYDLAIKQQISIAPGRMFTLQDQFDNCMRLCIGLPWSEELKFKLKQVGNLAKVLLQAAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR47</accession>
    <name>D7VR47_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13451"/>
    <dbReference type="EnsemblBacteria" id="EFK56248">
        <property type="protein sequence ID" value="EFK56248"/>
        <property type="gene ID" value="HMPREF0766_13451"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1165234_0_0_10"/>
    <dbReference type="OrthoDB" id="16158at117747"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="231" mass="25317" checksum="04512FDBDE667C55" modified="2010-10-05" version="1">MKYAYALIDLFKLNISSMSTQTNTSLTVIEKIKSIAVALVGTGMTVKGFTYFTPQLSYDIPRILIPVYKLLGPVGLAVSMTILGLILLLWSYSLWKKNLGKTISWIFIISILILSIVTLIITVGNKHEAVSAINAPVSPQSVDNSVVASGDVPVVFPAVFGAEAKQEYEQLIKELEQAIAAKDVGKSWSAYNSLNVFVAKLKTDQTDREPLNFIVAQTKKMDAYNLQIKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR80</accession>
    <name>D7VR80_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994656.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13484"/>
    <dbReference type="EnsemblBacteria" id="EFK56281">
        <property type="protein sequence ID" value="EFK56281"/>
        <property type="gene ID" value="HMPREF0766_13484"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1626017_0_0_10"/>
    <dbReference type="OrthoDB" id="2155549at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107565" evidence="1">
        <location>
            <begin position="21"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="165" mass="19305" checksum="40A96A55A576D639" modified="2010-10-05" version="1">MKNIILLFFTLTFLNTFVSAQKNNDYKGYEAFYKSFNTYFKYPQQLSKRCIPVYTIMMIKFGKKGNIDSIQFSDSAFPQFVSEVIRIKNNLNFKSIYNDLVDRNRNNDVVLIPIHIDIEQIGGCKSTIIPQDIVDLFKFSGERLTGNYFMYPGIYFKNFVGIPNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRH6</accession>
    <name>D7VRH6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OmpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_13580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994775.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13580"/>
    <dbReference type="EnsemblBacteria" id="EFK56377">
        <property type="protein sequence ID" value="EFK56377"/>
        <property type="gene ID" value="HMPREF0766_13580"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058370_1_0_10"/>
    <dbReference type="OrthoDB" id="583204at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107477" evidence="3">
        <location>
            <begin position="20"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="281"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="394" mass="43530" checksum="E5604638C869FCD4" modified="2010-10-05" version="1">MRIISLLFIALCISVTGSAQQSIRKDTTVVTDNSKYKVITNTFWSNWFLGAGAGAQLYFGDHNKQAPLSENLTPHFGLHLGKWFSPGLGLRIGAGGYQIKGLTQNGSHSTGEVYDASKWLDKQKFNYYHVYGDMLFNLSNLFSGYNPDRIYNISPYLGVGWMVTNDAPKQREVSANLGIYNTFGLAEALDLTLDIRGSMVNDRFDGETGGRKEEGALSALIGLTYKFKKRGWDRSKTTVISYDEEELNALRRRVNELAANNDALSKQLEEAGNKSMTNVIVNKNLLAAPILVTFKIGNSEVSNETRVNLGFFAKVIREGDQQVVYRITGYADKGTGTPEINQRLSMARAEAVKNILVNEFAVPARQLATVAAGGVDNMYYNDPKLSRAVIAFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRI7</accession>
    <name>D7VRI7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thump_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_13591</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994787.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13591"/>
    <dbReference type="EnsemblBacteria" id="EFK56388">
        <property type="protein sequence ID" value="EFK56388"/>
        <property type="gene ID" value="HMPREF0766_13591"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038123_0_0_10"/>
    <dbReference type="OrthoDB" id="1249244at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041497">
        <property type="entry name" value="Thump-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18096">
        <property type="entry name" value="Thump_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thump_like" evidence="4">
        <location>
            <begin position="324"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="394" mass="44653" checksum="63CE0B4EB83A721C" modified="2010-10-05" version="1">MNYNILQKEVQQFLQDNSKATPSAIALKKSPFAAVSSAELATQLDGRQRITRKLPKWANTPGIYFPEKLNLEQSSSEQTAEFKCNIIKPDSTVLDMTGGFGIDTYFFATKASQVTHCEINTALSEIVQHNFETLGVRNVKFVSTDAVAYLEQLPDNSLDYIYIDPSRRVNTRKVFLLADCEPNIADLQTLFFTKATTIISKIAPLMDISTALASLKYVKDVYVISVDNDCKELLFVQEKGYQAEPEIHSVRLFQGSQQELSFTYQQERQETNSYSTALAYLYDPDVAITKAGAFKTVGKQYQLHKLHSSTHLYTSAELKTSFPGRIFAVTQTLPYAAFKKADYPRQANIIAKNFPDKPEELRKRWKIKDGGEQFLFFTQDQDNSYIVIMASRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRU9</accession>
    <name>D7VRU9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M16 inactive domain protein</fullName>
            <ecNumber evidence="2">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995058.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13703"/>
    <dbReference type="EnsemblBacteria" id="EFK56500">
        <property type="protein sequence ID" value="EFK56500"/>
        <property type="gene ID" value="HMPREF0766_13703"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_6_1_10"/>
    <dbReference type="OrthoDB" id="1077305at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16_C" evidence="1">
        <location>
            <begin position="181"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="427" mass="48258" checksum="D3395847532FA8D6" modified="2010-10-05" version="1">MLNRSFAPSFNTIAGIDLVHPESLTFDNGLKTFLFHNPDQELVRLEWIFNNIYDKSENPLLNTTLSAMLKEGTTQLSSAQIAEQVDFYGAYLIPEYSYDQTSLTLYVLNKHVDKLLPLIKEILTAATIPQHELDTYIQNNKQTLSISLQKNDFVARRLFYTAVFGDNRYGNVPTAQAYDAISRTDLLHLYDQQILPQNCTLFIAGNVSESLIERVSQLFGEEWHSDTVIVAQQKPVLETSNGQLIVENKKDALQSAIRLGYPMINRTHPDFPAVQVVNTLLGGFFGSRLMRNIREEKGYTYSIGSAVASLKFSGFFTIASEVGVDVTSQTLSEIDKELDILCTEQAEEEELAVVKNYMLGSMLGSLESIFSHADKFKSVYFSGMTLDYYDRYAEVVKTMTTERVLEIAKQYFRKEDLIKVVVGQLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRV9</accession>
    <name>D7VRV9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacillithiol biosynthesis deacetylase BshB1</fullName>
            <ecNumber evidence="2">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bshB1</name>
        <name evidence="2" type="ORF">HMPREF0766_13713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995082.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13713"/>
    <dbReference type="EnsemblBacteria" id="EFK56510">
        <property type="protein sequence ID" value="EFK56510"/>
        <property type="gene ID" value="HMPREF0766_13713"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049311_3_1_10"/>
    <dbReference type="OrthoDB" id="1282433at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019213">
        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071793">
        <property type="term" value="P:bacillithiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023842">
        <property type="entry name" value="Bacillithiol_biosynth_BshB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04001">
        <property type="entry name" value="thiol_BshB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="240" mass="27039" checksum="4E98B3DBE68D146E" modified="2010-10-05" version="1">MKLDLLVMTVHPDDAELGAGGTIAKYVAEGKKVGIVDLTRGELGTRGTAETRTKEAQDAAEILGVVVRENLDLRDGFFENKEMEQREIIKCIRKFQPEIVITNALSDRHPDHGRASQLVNDALFLAGLRRIETEADGKPQEAFRPRLLLQLIQDQYIRPDVLLDVSDYWHIKEKAVLAYKTQFNSSGGEDDEPQTYISNPDFMKSTEGRGREFGRNIQVQYAEGFTSRKVLGVTDLFELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRY2</accession>
    <name>D7VRY2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995142.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13736"/>
    <dbReference type="EnsemblBacteria" id="EFK56533">
        <property type="protein sequence ID" value="EFK56533"/>
        <property type="gene ID" value="HMPREF0766_13736"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130337_0_0_10"/>
    <dbReference type="OrthoDB" id="2055010at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="177" mass="20270" checksum="AFCC9CD583E50012" modified="2010-10-05" version="1">MEEIRILNKDELFRIKEIDRSEEIAELYVYTQGRLVLIPHRESVSGFDPEELEEITVRQHQLVSEGGVVYGAFDQDKLIGTASVDYKRIGVRHNYSKMDILYVSHTYQGKGIGRQLLNACKNAALNFGADKLYISATPTRNTIDFYLKNGARLTRELNNELFAAEPDDIHLEMDLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS03</accession>
    <name>D7VS03_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase core domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13757"/>
    <dbReference type="EnsemblBacteria" id="EFK56554">
        <property type="protein sequence ID" value="EFK56554"/>
        <property type="gene ID" value="HMPREF0766_13757"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_31_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="74"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="252" mass="30127" checksum="6B02AEE08EC78B99" modified="2010-10-05" version="1">MCRSQYYYVSKKDNSAVIAALDQLSSKHPVYGFRKLYSYLRREGKPWNHKKVYRVYKLLNMNKKRRGKRRLPAREKQPLEQQISINRKWSMDFMSDSLARGNRFRTFNVMDDCSREILCIEIATSISSLRVTRTHEQIIDWRGKPLCLRVDNGPEFTSYHFEFWCKDQGIAIQFIQPGKPMQNGHIERFNRSYRKEILDAYLFFNLVEVREHTQAWMDEYNNNRPHEGLGNLTPTELSKNIRHKQQINQLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS84</accession>
    <name>D7VS84_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_13838</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995402.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13838"/>
    <dbReference type="EnsemblBacteria" id="EFK56635">
        <property type="protein sequence ID" value="EFK56635"/>
        <property type="gene ID" value="HMPREF0766_13838"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_3_10"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="187"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK56635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="288" mass="33650" checksum="CA978F97E4C7203C" modified="2010-10-05" version="1">MKAQFIELSPPSEKTIHIKLVDQNFLSNPLHFHELCELVLILESYGKRIVGNHVASFEAGDMVLMGPNVPHIWRNDDVFLNPLHEERAKAIVIYFPADFLLTLTDDQSTIYSMQHFIKKAQRGLRFYGKVLEKASHQIKSLVHKQSFSRITGFLNLIELLYQTHECENLASIGYKPTFGEQDTNRINNVYIYVMQNFREEVSLSMAAEIVNMTPNAFCRFFKRHTQKSFSKFVNEMRVGHACKLLMNRQLSISEICYQSGYQNLTNFNKFFKMIMQKSPREYRKDMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSC3</accession>
    <name>D7VSC3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase</fullName>
            <ecNumber evidence="2">1.7.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nqr</name>
        <name evidence="2" type="ORF">HMPREF0766_13877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.-.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995482.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13877"/>
    <dbReference type="EnsemblBacteria" id="EFK56674">
        <property type="protein sequence ID" value="EFK56674"/>
        <property type="gene ID" value="HMPREF0766_13877"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055322_4_3_10"/>
    <dbReference type="OrthoDB" id="1818437at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="173" mass="18891" checksum="24543796761FCAFB" modified="2010-10-05" version="1">MKNIIAIVGSAAAASSSHKIVGFLKTLLDDEIRLLVFDRLKELPHFDPTESTERPPIEIIALRQIIQDADAVLICSPEYIFSIPSGLKNLLEWTVATTIWMDKPVAIITASTDGEHTHKQLQLLLRTLGASVEANTCLHIPAVKSKINQEGQITDPDTQAALTCLATALQETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSM8</accession>
    <name>D7VSM8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995656.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13982"/>
    <dbReference type="EnsemblBacteria" id="EFK56779">
        <property type="protein sequence ID" value="EFK56779"/>
        <property type="gene ID" value="HMPREF0766_13982"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100971_1_0_10"/>
    <dbReference type="OrthoDB" id="2018542at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107632" description="OMP_b-brl domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl" evidence="2">
        <location>
            <begin position="7"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="194" mass="21243" checksum="950BE45107C1BA3E" modified="2010-10-05" version="1">MKKLFLTLTAITALTFAANAQTEKGKFIVGGQVGFSTSKIQDTDIKSSSFSIMPQVGYFVSDNFAIGTGIGYEYNKSETTTENVNDAFKVAPYGRYYLGEGPVKFFGQLTVPMAWGNQKVDDVKTNKTTNYGVELAPGFAYFPTSKIGIEFKVRGLYYNHGQVENIATDTKVKTNTFGLDANSLAPTIGVQFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSU5</accession>
    <name>D7VSU5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid/peptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0766_14049</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995815.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14049"/>
    <dbReference type="EnsemblBacteria" id="EFK56846">
        <property type="protein sequence ID" value="EFK56846"/>
        <property type="gene ID" value="HMPREF0766_14049"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004790_0_2_10"/>
    <dbReference type="OrthoDB" id="470322at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17346">
        <property type="entry name" value="MFS_DtpA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005279">
        <property type="entry name" value="Dipep/tripep_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="PTHR11654"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00924">
        <property type="entry name" value="yjdL_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="527"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="31"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK56846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="594" mass="66009" checksum="5E12A6DF54FCD61F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSW9</accession>
    <name>D7VSW9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995864.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14073"/>
    <dbReference type="EnsemblBacteria" id="EFK56870">
        <property type="protein sequence ID" value="EFK56870"/>
        <property type="gene ID" value="HMPREF0766_14073"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50336KZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141046_0_0_10"/>
    <dbReference type="OrthoDB" id="1958346at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="155" mass="17426" checksum="CAFE21220F79B337" modified="2010-10-05" version="1">MKTYISLLAVLISVLFTSCFKDHEEDFYLPDFRIEFQDAVMNTNSPGLSYPILKELRNKAGVQKYQVNLIGGLKDTDQTVKVRIRPESTAKADQHYKLPKGSELVIPANSAFGYFEVEIPELTNTTAVSLVFDLESNDQLKVSANYSTLGLTIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT02</accession>
    <name>D7VT02_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase</fullName>
            <ecNumber evidence="3">3.5.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pbpE</name>
        <name evidence="3" type="ORF">HMPREF0766_14106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.6" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995925.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14106"/>
    <dbReference type="EnsemblBacteria" id="EFK56903">
        <property type="protein sequence ID" value="EFK56903"/>
        <property type="gene ID" value="HMPREF0766_14106"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_0_4_10"/>
    <dbReference type="OrthoDB" id="537440at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005672200" evidence="1">
        <location>
            <begin position="20"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="36"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="472" mass="54409" checksum="2628A389A8B02630" modified="2010-10-05" version="1">MKKINIILVLCVLIHTCFAQQQQRQIKQLDSIFSMLNEQNQFNGTVLIADKGNILFEKGYGYRDEATKTYNNPETIFELGSASKQFTAAAIVLLKRQGKLRYEDSIEKYLPELGFWNKVTIYDLLRHTSGLPEFIIDMPKQWDASRIATNDDVIRFYAERKDSLQFKPKNFYRYNNTSYALLASIIERVSGKKYADFMADHIFKPLKMNSTFVYNSRLNPRDIKNYATGYVWAHNSFRKVVPEDTSYNDKKIYFLDGVVGAGKISSNVKDIYSWFKALESNTLLTKQEFEEMTEVTQNAYGKNIPYGLGFDLTKGENKFTYGNVGSWGGYVALLYRDVVKDRMIIVLENFKLGAYPFNNITQILENQPLKTEFKKKVQLSEADIKKYVGRYTDSRDPDEDYRITYADGHLIYNTSRSRLDLRFFPVSANEFQGIRQGGMDSALKFTVLDNGNIKLQMSEYGDIVATGIKTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT18</accession>
    <name>D7VT18_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage/plasmid-related protein TIGR03299</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995967.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14122"/>
    <dbReference type="EnsemblBacteria" id="EFK56919">
        <property type="protein sequence ID" value="EFK56919"/>
        <property type="gene ID" value="HMPREF0766_14122"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7QU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058825_1_0_10"/>
    <dbReference type="OrthoDB" id="1540547at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026325">
        <property type="entry name" value="DUF932"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017686">
        <property type="entry name" value="Phg/plasmid-like_prot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06067">
        <property type="entry name" value="DUF932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03299">
        <property type="entry name" value="LGT_TIGR03299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="357" mass="39189" checksum="65E248B28D1FD0D6" modified="2010-10-05" version="1">MAHNIHFNEQTGKHSFFSVQQKAWHGLGQIVEQYPTSEEAIKYAGLDYDVVKSPLFTKGSGIIETANGIEIGSTELEVPNYFANIRTDNNAVLGVVGKDYHIVQNREAFNFFDAIVGGGEGILYETAGALGKGERIFITAKLPDYIRVGNGDDVTEKYIFLTTSHDGSGSITAAFTPIRIVCQNTLNASLRSMTNVVRIKHTSGAKQRIENAHKIMGLANTLSNQLEGIFNNWTKVKVSDREVRKLIQLALCPNKETLDLINKGADDEVSTVFKNVVDNALLYAMTDDAQQMNTTKGTLFGAYNAVTGYFQNVRNYKDDEAKLQSIVLGGTAQLKSQKAFELCTAFALDGAEILNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT43</accession>
    <name>D7VT43_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2326 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996024.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14147"/>
    <dbReference type="EnsemblBacteria" id="EFK56944">
        <property type="protein sequence ID" value="EFK56944"/>
        <property type="gene ID" value="HMPREF0766_14147"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_461428_0_0_10"/>
    <dbReference type="OrthoDB" id="1105801at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018760">
        <property type="entry name" value="DUF2326"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10088">
        <property type="entry name" value="DUF2326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2326" evidence="2">
        <location>
            <begin position="443"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="337"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="591" mass="69538" checksum="196EDC6D923F2176" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT44</accession>
    <name>D7VT44_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996025.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14148"/>
    <dbReference type="EnsemblBacteria" id="EFK56945">
        <property type="protein sequence ID" value="EFK56945"/>
        <property type="gene ID" value="HMPREF0766_14148"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1030174_0_0_10"/>
    <dbReference type="OrthoDB" id="753915at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="270" mass="31680" checksum="CC9512BB977C5D3B" modified="2010-10-05" version="1">MANYQLPPLKDERLFEELTCDLFNFVENTSSYENTDFQTFGVKGQNQKGIDVFSTKTKTVIQCKLKSIGRKDETIRKNLIQDINTDLEKSRDLAIDFDKFVFVSTFRDDVQIQEYLNQIRKEKELPFHLYYWGWDTVTKHIEQSEALLHKYFPKFVKKSKPVKAKIELPDGALGKELSKKNYIDYLKKRYGDWKQIELSKKGEKFNWAAFTISLSKRYKASGINYIDVRHFDDLASYLKSRIDCTIMGKVNKSKGIKNYSAFEEFSENGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTB3</accession>
    <name>D7VTB3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aconitate hydratase</fullName>
            <shortName evidence="8">Aconitase</shortName>
            <ecNumber evidence="8">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">acnA</name>
        <name evidence="11" type="ORF">HMPREF0766_14217</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <text evidence="8">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996202.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14217"/>
    <dbReference type="EnsemblBacteria" id="EFK57014">
        <property type="protein sequence ID" value="EFK57014"/>
        <property type="gene ID" value="HMPREF0766_14217"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013476_2_1_10"/>
    <dbReference type="OrthoDB" id="363064at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="PTHR11670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="9">
        <location>
            <begin position="72"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="10">
        <location>
            <begin position="723"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK57014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="924" mass="102639" checksum="68F1F7E0EE9E91ED" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTC1</accession>
    <name>D7VTC1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, SP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_14225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996226.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14225"/>
    <dbReference type="EnsemblBacteria" id="EFK57022">
        <property type="protein sequence ID" value="EFK57022"/>
        <property type="gene ID" value="HMPREF0766_14225"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_10"/>
    <dbReference type="OrthoDB" id="955823at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="8"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK57022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="440" mass="48233" checksum="71248FEEC42A2967" modified="2010-10-05" version="1">MNTLFKLIIATVSLGGLLFGFDMAVISGAVPLIKAHFNLTPGQEGMFVSSALVGCIIGVVFAGRWSDRLGRKSTLVIAGTLFLVSAIGCTFSPDFISLLTSRWVGGLGVGIASIVVPLYIAEISPSQYRGRTVTIYQLAITIGILAAYVSNALVLKYDLSIAAEHWRMMFLLGAIPALLLCLGLFIVPESPRWLIQKGKENMGYKILSRLNINDPITPVAQQERQHVSLFSPVYRRAFILGLLLPLFSQLSGINAIVYFGPSILLQSGLSLDSSVQAQVFFGLANVIFTCVAIWKVDTWGRRPLYLTGTLGATISLLLTGWFLSQDIHTYGNLLIISILCFLLFFAFSIGPLKFVVASEIFPAAIRARAMAVSILVMWVADAIIGQLTPILLDQWGTAWTFRVFAICCAIAFVTVYYLLPETKGKRLEEIEAYWKSKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTF2</accession>
    <name>D7VTF2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative glutamate--cysteine ligase 2</fullName>
            <ecNumber evidence="2">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Gamma-glutamylcysteine synthetase 2</fullName>
            <shortName evidence="2">GCS 2</shortName>
            <shortName evidence="2">Gamma-GCS 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996309.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14256"/>
    <dbReference type="EnsemblBacteria" id="EFK57053">
        <property type="protein sequence ID" value="EFK57053"/>
        <property type="gene ID" value="HMPREF0766_14256"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044848_1_0_10"/>
    <dbReference type="OrthoDB" id="991285at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01609">
        <property type="entry name" value="Glu_cys_ligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011793">
        <property type="entry name" value="YbdK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02050">
        <property type="entry name" value="gshA_cyan_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="366" mass="42085" checksum="0DA005F476A0431D" modified="2010-10-05" version="1">MHKFTIGIEEEYQIIDAESRDLVSHVSKIIESGKAILSENLKHEMHESMVEMETGICQNIQHAREELTGLRRQLVKIAHDQGLRVSGGGTHPFSHWKDNVITKAERYNKIVNDMGDVARSNLIFGLHVHIGIPDREEGIRIQNVMRYFLPHVYALSTNSPFWVGRLTGFKSYRQEVFAKFPRTGIPSYFGSVAEFDAYVNLMIKTGTIDNAKKIWWDLRVHPFYPTIEFRICDMPFTIDETTCLAAIMQSLVAKIYKMHQQNISFRSYRRLLLSENKWRASKDGIHADLIDFGKETSVPYAILLDELLEFIDDVVDGLGCRKEVEYARQIVKMGTGADRQLMVFNETGDIKKVVDYMICETEKSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTF4</accession>
    <name>D7VTF4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996315.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14258"/>
    <dbReference type="EnsemblBacteria" id="EFK57055">
        <property type="protein sequence ID" value="EFK57055"/>
        <property type="gene ID" value="HMPREF0766_14258"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090325_0_0_10"/>
    <dbReference type="OrthoDB" id="1828423at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="237" mass="27811" checksum="F15A85183F835118" modified="2010-10-05" version="1">MPKVEYTEYYSHMLGRTINIQVTGHYGLPVIMFPTSQGSFTQNSDFHLNASVDYFTDNGKIKLFNLETLDQENLYNTRIPPHERIARYENYMLFLFLEYIPFIQKTHNVHRVAVAGCSFGAFHATNFAFRFPDVVSHLIAMSGAFSIRNFMDGYSSETVYFNCPEEFMQNDASWKFGHMHIVLSTSDQDVCLNKNQRMSEILRSKGIDHWYDEAKWIDHDWPLWRMAFPRFIGAYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTL4</accession>
    <name>D7VTL4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_14318</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996427.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14318"/>
    <dbReference type="EnsemblBacteria" id="EFK57115">
        <property type="protein sequence ID" value="EFK57115"/>
        <property type="gene ID" value="HMPREF0766_14318"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_1_3_10"/>
    <dbReference type="OrthoDB" id="554994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="7">
        <location>
            <begin position="36"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="6">
        <location>
            <begin position="235"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK57115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="506" mass="57344" checksum="A1674583B5E04219" modified="2010-10-05" version="1">MKKRYLLPFVLLGITSCQKDFLNQQDPNAVSVGSYFKTENDVLLAVNGLYQALRSGSSIGESSTLYSEERSDNTGRDDNQSNAGEPFQFNDFSILASNSYLKTHWSTMYDGIARCNTLLSNIDKVTFADPALKQRYIAEAKFVRALLYFHMVRKFGDIPLSTVEITTKEQANELAFRQKESVVYQQIVTDLSDALTSNLPDQQGQYAVGRASKAAINALLGQVYLTMGATLAGNANENFLKAEQHLTAAYGMRTFGKLNEIPYADVFDVTKKNTCKELIFQVQYLQGDQNYSSSIARNNQARGETINSQFTSTGIGGNVKRDLVKDYEDNDIRKAFSIKFAASTQVNDWFITKFRDNSNNAGKQGFGGNDWILIRYADVMLLLAETKMRLGKDAEAIVLLDEVRERAGLPSYAVSKANNTYNTKYPTLKDAILHERRVELAFENHRWFDLIRNYNAQELVTYFRKKEQADYGNAKISNISAKDRYYPIPFDEYKLNPEKMYQNQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTN6</accession>
    <name>D7VTN6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001673.1">
        <property type="nucleotide sequence ID" value="NZ_GL379777.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK55795">
        <property type="protein sequence ID" value="EFK55795"/>
        <property type="gene ID" value="HMPREF0766_14356"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141053_0_0_10"/>
    <dbReference type="OrthoDB" id="1410131at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107581" evidence="1">
        <location>
            <begin position="23"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="154" mass="17570" checksum="4D03575F3C3E8F36" modified="2010-10-05" version="1">MRNTRPFFFLFLLLLLAPDALQAQKNKWIWGPSVGYQYQRGNFLKVSGWNLFALNSKEYIKADAGADFTWMMDKTTVIPELGFTYYRGKDVVWSALKAEVTPYTFTPKIGIGLICLVDIAVGYGFDLRTKSQFKPVRGFTTSVNFNIPFNLTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTX7</accession>
    <name>D7VTX7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="4 11">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 15" type="primary">murC</name>
        <name evidence="15" type="ORF">HMPREF0766_14447</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MurCDEF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="4 11"/>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002294.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14447"/>
    <dbReference type="EnsemblBacteria" id="EFK55756">
        <property type="protein sequence ID" value="EFK55756"/>
        <property type="gene ID" value="HMPREF0766_14447"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028104_2_2_10"/>
    <dbReference type="OrthoDB" id="307881at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 11" id="KW-0133">Cell shape</keyword>
    <keyword evidence="10 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="12">
        <location>
            <begin position="9"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="14">
        <location>
            <begin position="118"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="13">
        <location>
            <begin position="308"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="120"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFK55756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="452" mass="50015" checksum="D7E4A283E849E83C" modified="2010-10-05" version="1">MNIDNIKRVYLIGIGGIGMSGLARYFHRLGCEVAGYDKTESDLTDTLVQEGIPVIYEDNIDAIPESFTHTGSDTLIIYTPAVPKELKIKNHLSNLGHELYKRSQVLGFISASRFTIAVAGTHGKTTTSTMIAHILKDSGYDCSAFLGGISSNYDSNVLFGANNTVVVEADEYDRSFLTLHPNIAVVTSADADHLDIYGDESHLIESFSLFLDRVVEGGTRIVKTGLPFKGQISYSGKGEGDVYAENIHVRDGEFYFDYVHHDGKISDIHLGIPGIHNVENAVAAITAARLLSIADAKIVKALSTFKGVKRRFEYVVRNPQTIYIDDYAHHPEELRAFISSMRKLYPAKKLTVIFQPHLFSRTRDFVDGFAEVLAMADELLLMEIYPARELPIEGVTSTWLADKIALENKRVVSPQEVLNIIKEEKPELVVTVGAGDIDRLIKPLKAILNDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTY7</accession>
    <name>D7VTY7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14457"/>
    <dbReference type="EnsemblBacteria" id="EFK55766">
        <property type="protein sequence ID" value="EFK55766"/>
        <property type="gene ID" value="HMPREF0766_14457"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2939439_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="60" mass="7234" checksum="C6FEDD683E7E53AE" modified="2010-10-05" version="1">MNQNNTYLTNVMLVLEHVFYIKQMKREVIAEYPKNAPLYPTCFQFFSKISRFLPLFQAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTZ4</accession>
    <name>D7VTZ4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14464"/>
    <dbReference type="EnsemblBacteria" id="EFK55773">
        <property type="protein sequence ID" value="EFK55773"/>
        <property type="gene ID" value="HMPREF0766_14464"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZEAT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2071633_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="118" mass="13003" checksum="26BCBA656FA76B7A" modified="2010-10-05" version="1">MIGRWNVVDKYAEVCVAISSYQYAANNPIKVIDAPNGVNSFSIDHNWDMLSGNDMGNNTSFRTSTEAGSPGVSHQNKTFVTEIGTFIKAYQKSKGDNSKLISDFINQMRSFGIKVTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGT8</accession>
    <name>D7VGT8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996872.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10207"/>
    <dbReference type="EnsemblBacteria" id="EFK59290">
        <property type="protein sequence ID" value="EFK59290"/>
        <property type="gene ID" value="HMPREF0766_10207"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033B95">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1460394_0_0_10"/>
    <dbReference type="OrthoDB" id="1626223at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="184" mass="20743" checksum="B6E479FB53242DD1" modified="2010-10-05" version="1">MKNLLTDNPAAIKALMSETLFSAGQSFAHSQKDEFLEATSIQTPLSAEVKTDVTEEFIYQGNKDKGIVFILRYQEYPYFSAGAQEAFVKTIGALQLSPSDVAVVNLANLHNPNDFKRIMQFFSPTKIILLGVEPTSLVLPHIPHNSYMKGRVATVFNTYSFEEMFVDIEKKKAFWIEFKTFIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGV7</accession>
    <name>D7VGV7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA1(Val) (adenine(37)-N6)-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.223</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">tRNA m6A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_10226</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43160"/>
            <dbReference type="Rhea" id="RHEA-COMP:10369"/>
            <dbReference type="Rhea" id="RHEA-COMP:10370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.223"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.223" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10226"/>
    <dbReference type="EnsemblBacteria" id="EFK59309">
        <property type="protein sequence ID" value="EFK59309"/>
        <property type="gene ID" value="HMPREF0766_10226"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4123">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061983_0_0_10"/>
    <dbReference type="OrthoDB" id="1027015at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016430">
        <property type="term" value="F:tRNA (adenine-N6-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01872">
        <property type="entry name" value="tRNA_methyltr_YfiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022882">
        <property type="entry name" value="tRNA_adenine-N6_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTS" evidence="4">
        <location>
            <begin position="27"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="236" mass="26828" checksum="CF112ACA0B34DFE0" modified="2010-10-05" version="1">MSSIFQFKQFAVDQTDCPMKINTDGVLLAATTADIPAAHILDIGTGTGVIALMLAQRFENAILEAVEIDALAADRAKQNFLNSPFSERMYAQHVSFEDLHPVSKYDLIISNPPFYTDSLHNPDNRKKTARHADLPFFERLFDFAGRHLMEEGLLRLILPPELAGQLQDIATTQELIAEHVIAVQSYKDSPVFRKMITWRKGGKKDLMTEELLIIYECKGVYSDRYKELLRPYFLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGV8</accession>
    <name>D7VGV8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996927.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10227"/>
    <dbReference type="EnsemblBacteria" id="EFK59310">
        <property type="protein sequence ID" value="EFK59310"/>
        <property type="gene ID" value="HMPREF0766_10227"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033SZM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_727416_0_0_10"/>
    <dbReference type="OrthoDB" id="1432441at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106927" evidence="1">
        <location>
            <begin position="23"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="380" mass="43343" checksum="E5D12176A1D094F5" modified="2010-10-05" version="1">MRNISFFLFTVLLLGISGVTRAQQTVSTPASCITTAQSALDKLVPALVKNDFDAIRDIVNVWERDCGKTEFLERIRILQLLISKSPYQTELDYYYNQKYDQQLIKRWNNADKKNYKEIYSKQPSLFDYVPLRHQADSLLKLKAKALLYSDSYQLADKDRKLIALFADDFNEIAAQQAESNQAKNDKGSYTEDYKDRVGYTIYAGTYGPLGGTNTTFGYNPVFGLTVMSSLRKNFIFEGGIKVRINSSDRDFQYLLYNETMDVNSAASFSVGGNVGYKALDRGKFMLIPKLGIGWEVISTGLSETVYNDNYVDEYGDGSSTRFHNVNTLHLGASLAGMYRVSRKNYIGLEIGYHYTPYQWDSNLITDIYNHYGSVELFFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGY9</accession>
    <name>D7VGY9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_10258</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997014.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10258"/>
    <dbReference type="EnsemblBacteria" id="EFK59341">
        <property type="protein sequence ID" value="EFK59341"/>
        <property type="gene ID" value="HMPREF0766_10258"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088548_0_0_10"/>
    <dbReference type="OrthoDB" id="1939800at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107188" description="Cytochrome c domain-containing protein" evidence="6">
        <location>
            <begin position="30"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="107"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="216" mass="23839" checksum="D9D12C81D59ADE7A" modified="2010-10-05" version="1">MKENMLAMNKKNFLGTVCAALAFAAVASACGDGTTRSTGWEFSRNMYDPIGYNPDQPNENFKNKQTAQTPPAHTNPVGFVRFEYANTLEDYERAGREVTNPLAVTKANLADGQALFNTYCAVCHGPEGKGDGSITKDREITDSRGTRKLENFPNPPSYHKTDAASSSRGGLMSDLTDGKIYHTIYYGHNSMGSHASQLSPDERWKVVMYVHELQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH94</accession>
    <name>D7VH94_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamate/leucine/phenylalanine/valine dehydrogenase</fullName>
            <ecNumber evidence="3">1.4.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gdhA2</name>
        <name evidence="3" type="ORF">HMPREF0766_10363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.3" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997252.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10363"/>
    <dbReference type="EnsemblBacteria" id="EFK59446">
        <property type="protein sequence ID" value="EFK59446"/>
        <property type="gene ID" value="HMPREF0766_10363"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_7_0_10"/>
    <dbReference type="OrthoDB" id="1184827at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004353">
        <property type="term" value="F:glutamate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="2">
        <location>
            <begin position="181"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="408" mass="45163" checksum="887BB9A3C49A2122" modified="2010-10-05" version="1">MKELLQAFERKRPEIIFEWKDNETEAEGWVVINSLRGGAAGGGTRMRAGLDRNEVESLAKTMEVKFTVSGPAIGGAKSGINFDPADPRKEAVLDRWFKVVTPLLKNYYGTGGDLNVDEIHDVIPLTEQYGLWHPQEGVLNGHFNVREKDRIHQIGQLRYGVSKVLEDAAFSPDLKRKYKVADMITGYGVAESVKHFYNLYGDTCSGKRAIIQGWGNVAASAAFYLSQLGVKIVGIIDRAGGLINKDGLTEEEITTLFLNRKKNELHTPDLLPFAQVNEEVWNIGAEIFIPAAASRLVSKEQVSQLVDNGLEVIASGANVPFADREIFYGPVMEFADQQVAVIPDFIANSGMARVFAYLMQPNVEISDEAIFSDVSAVIYNALQKIRKTTAERTHLSSHAYEIALKELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHB8</accession>
    <name>D7VHB8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glucosamine-6-phosphate deaminase</fullName>
            <ecNumber evidence="2">3.5.99.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997304.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10387"/>
    <dbReference type="EnsemblBacteria" id="EFK59470">
        <property type="protein sequence ID" value="EFK59470"/>
        <property type="gene ID" value="HMPREF0766_10387"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049611_1_0_10"/>
    <dbReference type="OrthoDB" id="1828393at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="PTHR11280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="1">
        <location>
            <begin position="9"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="245" mass="27276" checksum="461F6590C1356B54" modified="2010-10-05" version="1">MKIEKLENHQDLGKRAGQIGAEAIRQAIRKQGYANIILATGQSQFETIQELVRAEDLDWSKVRMFHLDEYIGLPVTHLASFRKYLTERFVNHVPALAEVVLIDGEVVPAEEECQRLARKIMDNPIDVAFVGIGENGHLAFNDPPADFEETAPYIVVNLDKQCRQQQLGEGWFPSLEDVPLQAISMSIRQIMKSKKIICAVPDSRKAQAVKDCLSGEVSNMHPASILQQHPDCTCFVDSGSGALLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHF6</accession>
    <name>D7VHF6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_10425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997411.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10425"/>
    <dbReference type="EnsemblBacteria" id="EFK59508">
        <property type="protein sequence ID" value="EFK59508"/>
        <property type="gene ID" value="HMPREF0766_10425"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069763_0_0_10"/>
    <dbReference type="OrthoDB" id="1987537at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="324" mass="37239" checksum="ACC9D7587444A9FC" modified="2010-10-05" version="1">MTNNTRKYLNLIIKIAVLLLAGWYIYSKVSNQHNLYEFKLLMKGLDRNLVTGVLIAVVVLMFCNWFLEIVKWKFISRRIEQISWWRATEAVFCGLTWAIFTPNRIGEYGGRVMYLKPENRASGAVAMGVGHFGQLVLTSIFGALSIAWFMTTFLSLQPVMKILVWAAGIAYAAVFLLIFFNVHWVDKLVRRINFLKKIQPFFSVLEDYNRRELSVILGLSLSRFIIFTSQYIILMEVILPDLPFLSMVLMIFILFFIQSAVPSLDLFDFSVRSFVASNLYSYITTQEIAVMAIVSCIWFVNLILPAILGSFFAIKVNYLSDNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHR3</accession>
    <name>D7VHR3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arginase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997656.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10532"/>
    <dbReference type="EnsemblBacteria" id="EFK59615">
        <property type="protein sequence ID" value="EFK59615"/>
        <property type="gene ID" value="HMPREF0766_10532"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709300_0_0_10"/>
    <dbReference type="OrthoDB" id="1598732at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="394" mass="45028" checksum="335B471210078473" modified="2010-10-05" version="1">MSLSVFFTPVSVNQFSAKDGFYKSQFGDSIVAFEENFPELEGDEKPQLVIFGVEEERGAVNNAGTAQAPDEVRKHLYQLYQGDYKIKIADLGNIKAGNTIRDTYFAVKSVVEELVKMDIVPIIIGGGHDLTYAQYMAYENLEQRVEVAIIDPRFDLDQEQVEDTPLNSQTFLNHIILHQPDYLFNLNNIAYQTYLVSKESVNMYDKLFFNATRVGAIAGKMDQSEPLIRAADMVSFDIGAIRSSEACGNANTNPNGLFGDEACQLARYAGMSDKCSSVGFYEFNPKYDPREQTAMLVSQMIWCFVDGYYNRKQDAPLVPKASYIIYRTTLESMDHELVFVKSKKSDRWWIQVPYFGSKSVNERYYLVPCRYEDYQLAVSGEMPDLWWRTHQKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHV1</accession>
    <name>D7VHV1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA binding domain, excisionase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997757.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10570"/>
    <dbReference type="EnsemblBacteria" id="EFK59653">
        <property type="protein sequence ID" value="EFK59653"/>
        <property type="gene ID" value="HMPREF0766_10570"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133781_1_2_10"/>
    <dbReference type="OrthoDB" id="2076478at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="45"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="99" mass="11318" checksum="0BD425491AAA93DF" modified="2010-10-05" version="1">MINSNQKIEVITLEHSVFQEIVETLQAIKKNIDSNDGTGPSIGTWLTTEEVSKLLKVSKRTLQKYRDEGKLGFSQIGSKIYYRSTDIDAFLLENYNPMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHV8</accession>
    <name>D7VHV8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10577"/>
    <dbReference type="EnsemblBacteria" id="EFK59660">
        <property type="protein sequence ID" value="EFK59660"/>
        <property type="gene ID" value="HMPREF0766_10577"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033TXP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_927191_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="300" mass="34179" checksum="FD9A368F8C424695" modified="2010-10-05" version="1">MEQQKPILSYKNHHKQRIVMVIVLMILAGASAGYFFYSKNVRKPLAAVKKEKTDSLKRDILLSDSTKKEIIRQNPPPSEIEEVPTAYSERYVIQPVTVNGRPFRFGDKVFVNDERSDAEKSFVHLRTSSGSFSATALLINSEILVSESQYEEYRQYFSLSPFSELDLKTKKLLLSETYSNGTTYNITQNAERARSTICFGDFDTDGKKDVAIITDNNEMQKSRLLIICTNTATQEKYLAFSENYSDKMKVNSFKKGAKVIMNTASLTPAPVDGIILQAEDVKLAIMYDLQLQKFKTYYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHY5</accession>
    <name>D7VHY5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="3 12">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">mutY</name>
        <name evidence="14" type="ORF">HMPREF0766_10604</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Adenine glycosylase active on G-A mispairs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="3 12"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997839.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10604"/>
    <dbReference type="EnsemblBacteria" id="EFK59687">
        <property type="protein sequence ID" value="EFK59687"/>
        <property type="gene ID" value="HMPREF0766_10604"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_0_3_10"/>
    <dbReference type="OrthoDB" id="1274533at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03431">
        <property type="entry name" value="DNA_Glycosylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005760">
        <property type="entry name" value="A/G_AdeGlyc_MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14815">
        <property type="entry name" value="NUDIX_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01084">
        <property type="entry name" value="mutY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 12 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="13">
        <location>
            <begin position="35"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFK59687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="349" mass="40263" checksum="CC00128B6C290CB6" modified="2010-10-05" version="1">MSFSKRLIAWYDQHGRDLPWRHTQDPYIIWLSEIILQQTRVEQGMPYFMRFSEQYPTVQDLASADEDDILNLWQGLGYYSRGRNMHKAARMVVSDFAGIFPTAYDEVIKLPGVGEYTAAAISSISANQAKAVLDGNVFRVLSRYFGVEVEINTPAGKKIFTELANEMLDADDPARYNQAIMDFGAMQCKPKSPTCGSCIFNQECVAPKEDKVHLLPLKKKGKGSRNRYFHYFIIEEDDKIMMSRRGEGDVWQNLYEFPMIETTEPLSGLDILKDERTKEYFSEDISLELKGNVIKHILSHQNIYAQFYKVNNPSALKLKKKSWNYVFLKDLNKLAQHKLIFSFIETNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI65</accession>
    <name>D7VI65_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997999.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10684"/>
    <dbReference type="EnsemblBacteria" id="EFK59767">
        <property type="protein sequence ID" value="EFK59767"/>
        <property type="gene ID" value="HMPREF0766_10684"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025928_1_0_10"/>
    <dbReference type="OrthoDB" id="367622at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041662">
        <property type="entry name" value="SusD-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12771">
        <property type="entry name" value="SusD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="521" mass="59129" checksum="CE4CA5037DD00E04" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI80</accession>
    <name>D7VI80_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="9">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">asnB</name>
        <name evidence="9" type="ORF">HMPREF0766_10699</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="9"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998029.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10699"/>
    <dbReference type="EnsemblBacteria" id="EFK59782">
        <property type="protein sequence ID" value="EFK59782"/>
        <property type="gene ID" value="HMPREF0766_10699"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014658_3_1_10"/>
    <dbReference type="OrthoDB" id="610569at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="354"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="604" mass="69573" checksum="8B02DE2465B07B49" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIB7</accession>
    <name>D7VIB7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin--[acetyl-CoA-carboxylase] ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998103.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10736"/>
    <dbReference type="EnsemblBacteria" id="EFK59819">
        <property type="protein sequence ID" value="EFK59819"/>
        <property type="gene ID" value="HMPREF0766_10736"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051096_3_1_10"/>
    <dbReference type="OrthoDB" id="1842956at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="248" mass="28305" checksum="9E1D9A7B710A7921" modified="2010-10-05" version="1">MGLNLIKLDRVASTNDYLREQLSNFKPLDEGSAIMATEQFQGKGQRGNIWRSEPGKNLTLSLLLYPSFLEVSKQFFLNVAISIGIAKWLQTQTTAQISVKWPNDIMGNQKKVCGILIENQIKKDSFSSSIIGMGININQTDFPDEISHKVCSLKKLLQKPDDISIDNLLPELFYYLETQYDRLKAGDNTELLKDYNSMLMWRGEKHNFLIDNVKVEGTITEVDEDGQLWVDFGKKLVSFNLKEIAYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIF0</accession>
    <name>D7VIF0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998166.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10769"/>
    <dbReference type="EnsemblBacteria" id="EFK59852">
        <property type="protein sequence ID" value="EFK59852"/>
        <property type="gene ID" value="HMPREF0766_10769"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3871">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091428_1_0_10"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrid_ox_like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="172" mass="19668" checksum="09FD3FDAC7EACABA" modified="2010-10-05" version="1">MNTEQNREENLDGQKALEKIREIVDDAKTCFFCTDIRTGVPLSVRPMTVLQVDDNGYLWFMTSSQTHKDEEVAKDPFVNLMMQSGKRAGFLNLYGIAEEMQDQEKINELWSPALEIWFDGPEDPRIVLLRVEILEGHYWDNKNIAPVAAFKMLKSLLTGKPDHDGIHGDLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIK2</accession>
    <name>D7VIK2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10821</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998265.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10821"/>
    <dbReference type="EnsemblBacteria" id="EFK59904">
        <property type="protein sequence ID" value="EFK59904"/>
        <property type="gene ID" value="HMPREF0766_10821"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_2_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107533" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="3">
        <location>
            <begin position="112"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="890"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="966"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="895"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="966"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1005" mass="109902" checksum="1392F1413B2D6CA8" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIL4</accession>
    <name>D7VIL4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator, Rrf2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998292.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10833"/>
    <dbReference type="EnsemblBacteria" id="EFK59916">
        <property type="protein sequence ID" value="EFK59916"/>
        <property type="gene ID" value="HMPREF0766_10833"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107144_1_1_10"/>
    <dbReference type="OrthoDB" id="1794390at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="147" mass="16591" checksum="99EBBB0061784FB1" modified="2010-10-05" version="1">MLSKKTKYAIKALMVLGRNYGKEPMQIVKIADEENIPKKFLEQILLEMRNAGILYSKKGAGGGYSLNKAPEDVFLSQVMRLIDGPIALLPCVSLNFYRSCDECTEEHVCGIRDTFIDVRNAMLQILNDTSIAHLINKEKELNLDIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIQ0</accession>
    <name>D7VIQ0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase</fullName>
            <ecNumber evidence="3">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998370.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10869"/>
    <dbReference type="EnsemblBacteria" id="EFK59952">
        <property type="protein sequence ID" value="EFK59952"/>
        <property type="gene ID" value="HMPREF0766_10869"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_0_4_10"/>
    <dbReference type="OrthoDB" id="537440at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106998" evidence="1">
        <location>
            <begin position="19"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="445" mass="51046" checksum="8ABDBAC1641ACD50" modified="2010-10-05" version="1">MKSLLLLVFILAGSICCAQTIRKERLDSVLNHIEQYNQSLGNVSVYKDGKEVYNRSFGQSKVRDLTFDEHTSYQIGSVTKLVTSVLLWKLVEQGKLNLEEKLSTYFPDIPNADKIHLSQILSHNSGLGDYTSIGEGEPWLIEKRSVDTILSVIRHGKPLFEPGTDMRYSNSGFYLLTKIIEKCYKKPYAKIVEKEIVKPLKLKDFRSFDNYNNNYFRSYKFIKEWIEVPDFYPQNIIGVGDILATPRDLNNFLEGLFAGKLLKKETLEKMKAGKDNNGFGKGFMYIPYKKNVFLGHGGDTYGTHTLAGYNVQDKIAISITINGQRYEHNAVYIAILGAIYDPELKLPEFETNVLKLSPEQLKQYEGLYSSADFPLKIKIFQEDGELYGQADGQGAFPLTCYKEDKFMFEAAQIYMDFSPAQDSMFYRQRSNEVNFKRLKIEQVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIY2</accession>
    <name>D7VIY2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TIGR02453 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998537.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10951"/>
    <dbReference type="EnsemblBacteria" id="EFK60034">
        <property type="protein sequence ID" value="EFK60034"/>
        <property type="gene ID" value="HMPREF0766_10951"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036742_2_0_10"/>
    <dbReference type="OrthoDB" id="1258218at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015996">
        <property type="entry name" value="UCP028451"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="PTHR36452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028451">
        <property type="entry name" value="UCP028451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02453">
        <property type="entry name" value="TIGR02453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK60034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="222" mass="25690" checksum="1F5E1E68CE5F318F" modified="2010-10-05" version="1">MAKIEKQTFSFLEALRPNNNREWFQENRGLYEASLANVKAFIRGIIDALSAFDPHIHTDISESKCLFRIYRDTRFSNDKTPYKTWFSAGISVDGRKLDGPEYYLHIEPGKSFLGVGYWRPNKEHLDAIRQEIDYNAEGFYKALQDHQWKASDLSAEDKLVRPPAGYDASHPEIEILKLKSFILYRKFSDKELMASDALDKVIEAAHSMFAFKAYIHQAIDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ21</accession>
    <name>D7VJ21_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002115.1">
        <property type="nucleotide sequence ID" value="NZ_GL379779.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10990"/>
    <dbReference type="EnsemblBacteria" id="EFK59156">
        <property type="protein sequence ID" value="EFK59156"/>
        <property type="gene ID" value="HMPREF0766_10990"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5646">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119457_0_0_10"/>
    <dbReference type="OrthoDB" id="1278667at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="24"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="152" mass="17658" checksum="CC94614C0C8030D1" modified="2010-10-05" version="1">MIIKADNVEEYIENVPPDRKTPVITLRENILKNIPEGFEETISYNMIGYVVPHSLYPAGYHCTPKLPLPFMNIASQKNFIAIYHMGLYADSEINEWFRLAYTSLYNTKPDMGKGCVRFKKMDKIPFELIGELAGKISVQDWIDIYERSFVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ26</accession>
    <name>D7VJ26_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Antioxidant, AhpC/TSA family</fullName>
            <ecNumber evidence="4">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ccmG5</name>
        <name evidence="4" type="ORF">HMPREF0766_10995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.15" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002125.1">
        <property type="nucleotide sequence ID" value="NZ_GL379779.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10995"/>
    <dbReference type="EnsemblBacteria" id="EFK59161">
        <property type="protein sequence ID" value="EFK59161"/>
        <property type="gene ID" value="HMPREF0766_10995"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_1_0_10"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="226"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="364" mass="41332" checksum="389484037FAB12F5" modified="2010-10-05" version="1">MKRSLFAAVLSLIMMACSNKEEYTVSGQIENPGNIKVVSLYEGDRKLDSVYLNESHKFSFVRPSTQARLLSLEVGKKRYYIIAQPGEEVILKADLQKEPYEYEVSGSDLSAAIKEFAPVRIRRDVIQDSLQNEFAKRTDNLNAEQIESLRGEYMTKFKAALHYYNDQAIAFKNKHRDLAGFYAMSTLDPEVAEAEIIAYADEIKDDFKDNGYVDQFKQETAKLKVLAVGQPAPLFEAYTPQNKLVKLSDYKGKYTLVDFWASWCAPCRQENPNIVKQYHAFKGKGFDVLGVSLDNNPGPWMRAIADDKLEWTNISDLQAWGSEVVGLYRIKAIPTSYIVDPEGKIAAKNLRGKDLEEFLKKTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ75</accession>
    <name>D7VJ75_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bifunctional protein FolC</fullName>
            <ecNumber evidence="5">6.3.2.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">folC</name>
        <name evidence="5" type="ORF">HMPREF0766_11044</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000415.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11044"/>
    <dbReference type="EnsemblBacteria" id="EFK58928">
        <property type="protein sequence ID" value="EFK58928"/>
        <property type="gene ID" value="HMPREF0766_11044"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015869_1_1_10"/>
    <dbReference type="OrthoDB" id="1232874at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="4">
        <location>
            <begin position="52"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="436" mass="48137" checksum="57B24FBF87238707" modified="2010-10-05" version="1">MKAYKEVIEYLYTRLPMFTREGVSAYKKDLDNTIALCQALGNPQDKFKSIHIAGTNGKGSSSHMLASVLASAGYKTGLYTSPHLVDFRERIRVNGEVIPEQNVIEFVESQQSLIEKVQPSFFEVTVAMAFDYFAKAQVDVAIIEVGLGGRLDSTNIIRPELCLITNIGMDHMNLLGNTLQEIAGEKAGIIKANTPVVISERDPRTAQVFEEIAEEKQAPIRFASDTMEATITSRHPVGMKVSVTDTMNSLTEQYDLDLTGSYQLKNVIGVLTAVEELNHINFTIPSDRLREGLSHVQQYTGLQGRWQTISTEPLIICDTGHNEDGIREVLKNLQLTPYEVLHIVMGAMKDKDLEHILPLLPKEAIYYFSSPDMPRAMPAEELSAAALSYGLKGKPYPSVMQAFTAAKQAYQAGDLVFIGGSNFVVAEVLTALENKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ92</accession>
    <name>D7VJ92_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cytA</name>
        <name evidence="8" type="ORF">HMPREF0766_11061</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000467.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11061"/>
    <dbReference type="EnsemblBacteria" id="EFK58945">
        <property type="protein sequence ID" value="EFK58945"/>
        <property type="gene ID" value="HMPREF0766_11061"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058582_0_0_10"/>
    <dbReference type="OrthoDB" id="1297285at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="69"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="193"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="325" mass="36127" checksum="7807AA25486D103B" modified="2010-10-05" version="1">MEEELRKSGRIIRYVIGLSIILVCFIVLSLYFTIHPPISQAMATEHPDSILTHVDQYEGISFGDNTEGKLAAEGEKLIKETYNYFYKDGQKIGNRLACTNCHLNGGTKAFAAPYIGLSGVFPIYIGREDKIESLEERINGCFERSMNGQAIDVNSMEMRAIVTYIKQISTKAPIGKRIAGQGFVKIVVPERAANPKTGAVIFQKQCQSCHGNTGQGVKLANNKGYQYPPLWGEDSYNDGAGMARLLTAAKFIKANMPLGATYEAPVLSDEEAYDVAAYINSFPRPVKANKEKDYPNLEKKPKDSPYPPFNDQISQLQHKYGPYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJF6</accession>
    <name>D7VJF6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADH-ubiquinone/plastoquinone (Complex I) family protein</fullName>
            <ecNumber evidence="13">1.6.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">mrpA</name>
        <name evidence="13" type="ORF">HMPREF0766_11125</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.-.-" evidence="13"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000615.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11125"/>
    <dbReference type="EnsemblBacteria" id="EFK59009">
        <property type="protein sequence ID" value="EFK59009"/>
        <property type="gene ID" value="HMPREF0766_11125"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_2_1_10"/>
    <dbReference type="OrthoDB" id="1274678at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025383">
        <property type="entry name" value="MbhD-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13244">
        <property type="entry name" value="DUF4040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="595"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="681"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="741"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="11">
        <location>
            <begin position="61"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="10">
        <location>
            <begin position="124"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4040" evidence="12">
        <location>
            <begin position="607"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFK59009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="769" mass="84420" checksum="A4EF934B68E3057E" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJG1</accession>
    <name>D7VJG1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative monovalent cation/H+ antiporter subunit F</fullName>
            <ecNumber evidence="10">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mnhF</name>
        <name evidence="10" type="ORF">HMPREF0766_11130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cell membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.5" evidence="10"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000626.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11130"/>
    <dbReference type="EnsemblBacteria" id="EFK59014">
        <property type="protein sequence ID" value="EFK59014"/>
        <property type="gene ID" value="HMPREF0766_11130"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125825_1_2_10"/>
    <dbReference type="OrthoDB" id="2083248at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007208">
        <property type="entry name" value="MrpF/PhaF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34702">
        <property type="entry name" value="PTHR34702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04066">
        <property type="entry name" value="MrpF_PhaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028784">
        <property type="entry name" value="MrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0050">Antiport</keyword>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK59014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="91" mass="10314" checksum="112D7109FDD8274B" modified="2010-10-05" version="1">MMLNTYFDYVILPILTISVILTFIRLFKGPDVVDRVIALDLIITIGIGIITVYSIRTQQEVLLDVAIILALIAFLGTVAFSYYLEKKDHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJK6</accession>
    <name>D7VJK6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000708.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11175"/>
    <dbReference type="EnsemblBacteria" id="EFK59059">
        <property type="protein sequence ID" value="EFK59059"/>
        <property type="gene ID" value="HMPREF0766_11175"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015150_0_0_10"/>
    <dbReference type="OrthoDB" id="718248at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001681">
        <property type="term" value="F:sialate O-acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005181">
        <property type="entry name" value="SASA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039329">
        <property type="entry name" value="SIAE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22901">
        <property type="entry name" value="PTHR22901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03629">
        <property type="entry name" value="SASA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SASA" evidence="2">
        <location>
            <begin position="111"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="SASA" evidence="2">
        <location>
            <begin position="299"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="507" mass="58077" checksum="0C6ABD42C5476517" modified="2010-10-05" version="1">MLNMKTTVLKYALSCLALVLLDICKADIRLPALLSDNMLLQQNTKVRLWGSADPGEQVTVRASWTADNFITTADYAGKWMLTIETPKASDKTYELLFNGKNEIRIRNILVGEVWLCSGQSNMDFPVAKSTGWRTGILDEEQHMKEADFPEIRLFHVRQTLSPKVPLEDCEGEWMICNPDNLKEFSAVAFFFGRKIHRQTKLPVGLIQTTWGGTHAESWTPMPVMQHNPLYTTLIEEQNKAEESYPQDSLIYQKELKDYEEARSKGQQLPKKPKEPLGIYHNKALSTLWNGMVNPLVPYTIKGVIWYQGESNSVRYQDYQQVFSNMIQSWRTAWKQKDMPFYFVQIAPHYKQPPEIREAQLKTWQSVQHTGMVVITDVGDSTDIHPRNKQVPGERLANWALAKEYKIPVAYSGPLYRKKKIQKDKVILSFDYVSKGFLSDGKAIKGFEIAGADQHYYPATATVQGTQLWVSSEQVKQPLYVRYAWGKYKPGNLYNAEGLPASPFRTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJL6</accession>
    <name>D7VJL6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000728.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11185"/>
    <dbReference type="EnsemblBacteria" id="EFK59069">
        <property type="protein sequence ID" value="EFK59069"/>
        <property type="gene ID" value="HMPREF0766_11185"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052647_0_0_10"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="343" mass="39295" checksum="53523DA0D894988B" modified="2010-10-05" version="1">MRSNHLHAVLQLDKTSAAPKYLQLANAIMKAIRVGDLSKNDLLPSINELSAILDLSRDTIEKGYRYLKKNGIILSVPGKGYFIAHTDLDKKGYIALFFNKLSAHKKIVYDSFVKTMGEDYGIDLFVYNNDVNYFKSLLKNLNKDYQHIVVIPHFIKGKDQEIDIIREIPKDKLIVLGKELPELQGEYACVYENFEKDIYNALKQANKSLAKYKTLKLIFPDNSYFPKGIIKGFYKFCQEFKFEHLLVSNIQKEQISAGEVYINLIEEDLVRLLDKVLSLDLEIGKDVGVISYNETPLKKFILSGITTISTDFKEMGKLAAKVILNKSKDKIEVPFYLKMRNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJP8</accession>
    <name>D7VJP8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HMGL-like protein</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">leuA</name>
        <name evidence="3" type="ORF">HMPREF0766_11217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11217"/>
    <dbReference type="EnsemblBacteria" id="EFK59101">
        <property type="protein sequence ID" value="EFK59101"/>
        <property type="gene ID" value="HMPREF0766_11217"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_3_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="388" mass="42781" checksum="3935AFC36DEAC6BC" modified="2010-10-05" version="1">MLHDPNHLYIFDTTLRDGEQVPGCQLTTPEKIEIAKDLEKLGVDVIEAGFPVSSPGDFQSVVELSKAVNDVIICALTRANKNDIDVAAEALKFAKRPRIHTGIGSSDLHIQYKFNSTREEILERAVSAVKHAKSYVEDVEFYAEDAGRADLEYLAKMVEAVIAAGATVVNIPDTNGYCLPDQYGAKIKFLKENVKNIDQAIISAHCHNDLGLATANSIAAVQNGARQVECTINGIGERAGNTSLEEVAMILKVHNQVFGGLTSNINSQMFTYISRKVSEMMNMPVQPNKAIVGRNAFAHSSGIHQDGFLKHRETYEIIRPEDVGLLEADIILTARSGRHALKHHLERLGYQLEKEELALTYQRFLVLADAKKDICDEDLVTLVTSRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJT0</accession>
    <name>D7VJT0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000899.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11249"/>
    <dbReference type="EnsemblBacteria" id="EFK59133">
        <property type="protein sequence ID" value="EFK59133"/>
        <property type="gene ID" value="HMPREF0766_11249"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031C3G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066214_1_1_10"/>
    <dbReference type="OrthoDB" id="1509557at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005901">
        <property type="entry name" value="GLPGLI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09697">
        <property type="entry name" value="Porph_ging"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01200">
        <property type="entry name" value="GLPGLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107299" evidence="2">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="299" mass="33909" checksum="BDA70F3CC6AB7ADB" modified="2010-10-05" version="1">MKKSYLFLIGLFLLSSARAQQTEPALAKAHYLFKHVNDTSNREQFRRDEMVLYLGKNSSYFTSYSSNRAQEDIKKQMDNPAFDGNLKIVRNTSPTQESYYCRPHEHKLTELKDVAGDKFLVDTQWPELDWNIGEETRKIGGYKTQKAQTNYKGRNYTAWFTTELPFPFGPWKLQGLPGLILEAYDDKKEVIFEYSGFDKLDNGLLNVELPANAVKSNLKEIKKIQDAFHANPQAYIQAKQAQRQNAAGVSVSGNSISVSATSAKASGEMDMSKIKSVNVQQDDNYKPSKITNNPIELIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJX5</accession>
    <name>D7VJX5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11294"/>
    <dbReference type="EnsemblBacteria" id="EFK58577">
        <property type="protein sequence ID" value="EFK58577"/>
        <property type="gene ID" value="HMPREF0766_11294"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_10_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107228" evidence="3">
        <location>
            <begin position="30"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="366"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="452" mass="50620" checksum="CAB8698709FCC5BD" modified="2010-10-05" version="1">MEILNINMNRISKWLMLLLSIGIFGSAYAQEELTLKEAIQYALQNKADAKKSKLDVINAENKISEVRSNALPQINLSAGLTYNPIIQKIALPDFTGQTGGTTLVEMGQKWQATPTVSMTQQIFNQSVFTGLKAASTTRAFYQVNHEMTEEQLIERVANSYYDVYQAKMQLETIESNLKSTRKTRDVIFGSYSNGLAKKIDLDRTDVAVNNLESSKLQKMNEIQLKENALKFVIGMDVNKEIQMPKSTFNIDLKIANLDTAQLDNRTEIKLLATQRQLNIFNKKSIEAQYYPTLSLQASYGYAGFGQKFPLVNNNGVWANFASIGLNLSFPIFNGFATRSKVRQAQIDIDKLDVDIADRKLGLMTEANNAQKQLKNSLLNINVQQANMELAKEVLSNVENNYKNGLATLTDLLDAEKAYAEAQNNHSTALLNYKVAEIQIIKSNGNLKSLINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK89</accession>
    <name>D7VK89_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ada_Zn_binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999034.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11408"/>
    <dbReference type="EnsemblBacteria" id="EFK58691">
        <property type="protein sequence ID" value="EFK58691"/>
        <property type="gene ID" value="HMPREF0766_11408"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2566016_0_0_10"/>
    <dbReference type="OrthoDB" id="1895308at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="SSF57884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ada_Zn_binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="83" mass="9695" checksum="D503E7F1F4113CBA" modified="2010-10-05" version="1">MLIRHIACVDAEIRSKIRTSEICFAGNRKLKIYGKLSCRSGKRMLRQNRVFFASEQQALLGGYRPCGHCMRAEFVKWKNTEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKH5</accession>
    <name>D7VKH5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11494"/>
    <dbReference type="EnsemblBacteria" id="EFK58777">
        <property type="protein sequence ID" value="EFK58777"/>
        <property type="gene ID" value="HMPREF0766_11494"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_663335_0_0_10"/>
    <dbReference type="OrthoDB" id="929642at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05483">
        <property type="entry name" value="retropepsin_like_bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034122">
        <property type="entry name" value="Retropepsin-like_bacterial"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106985" evidence="1">
        <location>
            <begin position="24"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="501" mass="55903" checksum="AB7B4FDD90D51590" modified="2010-10-05" version="1">MNRIFFRSILIFLHLLCLNFAFAQQDHKLVQQIRQAFKDKNSANLKAALAPSFSIAGNTQQGAVRYLDHILSSYAAENVRFISMQKQNSGHKVAIEISKTDKSTVQTAFYTDSADRILYMDLFDQLYGMNRYQTSRLRAKIPFENHDGTIILSVKINDFKRPLRLLFDTGADGMAVSQQLADEIGLKVTRQNNASVVGGNMQIQVSDNNKISLDTLKLQGQGIAIFPEMHRETDGIIGNSLVKRFITKVDYDKCELLLYDFGDYQYEQQGHAIPVEMPAGLLIIPGNLEIRPGKAYPGNFVFDTGASYSLICFRPFVRTNRLLVSGFKPEYQGTTASMGMVSPTFTGRSHSFSFSHLPAVPDLPVTLMAGGANNENWKPEFDGSIGVRLISRYNFTINLQNREIYLEPNHLYPYPQDFSIGSYLFGYDSEGKLRLLSLVGAEDEKVKLATGAAISSINGIPTHTFLKDKAALESILNLEKGTSITVESSSDTVKKSYTISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKJ9</accession>
    <name>D7VKJ9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
            <ecNumber evidence="2">2.3.1.128</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.128" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999335.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11518"/>
    <dbReference type="EnsemblBacteria" id="EFK58801">
        <property type="protein sequence ID" value="EFK58801"/>
        <property type="gene ID" value="HMPREF0766_11518"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_1_10"/>
    <dbReference type="OrthoDB" id="1497607at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="172" mass="20175" checksum="26698F98F8A2666A" modified="2010-10-05" version="1">MEKVIIETERLIIRELEDSDCRGIFRLDSNPEVHRYLGGKPLTTEKQASEVIAFIRKQYQEHGIGRWAVIQKESNEFIGWSGFKLIKVMTNNHIDYLDIGYRFVQEAWGQGYATESGKACLQYAKTHLTNYSIHAISDINNLDSKKVLEKLGFEAKEIFDYENQLHFWYHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKX7</accession>
    <name>D7VKX7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD hydrolase, family IA, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999606.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11646"/>
    <dbReference type="EnsemblBacteria" id="EFK58250">
        <property type="protein sequence ID" value="EFK58250"/>
        <property type="gene ID" value="HMPREF0766_11646"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_1_10"/>
    <dbReference type="OrthoDB" id="1167152at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="220" mass="25193" checksum="74EE8280FCC84811" modified="2010-10-05" version="1">MNKFKAVFFDLDGTLIDSEYFYFQNWQPILAEDFAIHINFEDWIVHFAGHTLAVNIETMKRVWNVDTTDEYMWKRTRAAYAQSDMRTIALMPYAKEILEHLKAHQVKIGLVTSSYQTTVDTVLGHHDLLSYFSLIVTRDHVQSPKPDPEPYLLAAKQSGLNPKDCVAIEDTITGTKAAKAAGLYCIGVTKQPVEREKLIIADQLFTDLQEVWDHLKNNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL96</accession>
    <name>D7VL96_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-antigen polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999907.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11765"/>
    <dbReference type="EnsemblBacteria" id="EFK58369">
        <property type="protein sequence ID" value="EFK58369"/>
        <property type="gene ID" value="HMPREF0766_11765"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_384901_0_0_10"/>
    <dbReference type="OrthoDB" id="118614at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="718" mass="82938" checksum="22E7395F94CF8AD3" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLD7</accession>
    <name>D7VLD7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="6">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">punA</name>
        <name evidence="8" type="ORF">HMPREF0766_11807</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000024.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11807"/>
    <dbReference type="EnsemblBacteria" id="EFK58410">
        <property type="protein sequence ID" value="EFK58410"/>
        <property type="gene ID" value="HMPREF0766_11807"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054456_1_0_10"/>
    <dbReference type="OrthoDB" id="1364220at2"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011270">
        <property type="entry name" value="Pur_Nuc_Pase_Ino/Guo-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="PTHR11904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01700">
        <property type="entry name" value="PNPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="7">
        <location>
            <begin position="39"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="287" mass="32154" checksum="2E1B26B51051EEDE" modified="2010-10-05" version="1">MQKKCVKFEFKLFFARMYQSIEETVSFIKKRIGDFVPEFGIILGTGLGKLVDEIDVEFQLMYSNIPNFPISTVEFHSGKLIFGTLNGRKVVAMQGRLHYYEGYSMREITFPVRVMKVLGIQKLFVSNASGSLNPEIKKGDLGIIDDHIDLLPDNPLRGGNENVFGPRFPDMSRPYDPTMTKQALDIADKLGFKAHKVVYVSTPGPNLETRAEYRYMRIIGGDIVGMSTVPEVIVANHMGLPVFAISVVTDEGFHDELTPVSLQEIVDVAARSEPKMTAIMKELIALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLH9</accession>
    <name>D7VLH9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11849"/>
    <dbReference type="EnsemblBacteria" id="EFK58452">
        <property type="protein sequence ID" value="EFK58452"/>
        <property type="gene ID" value="HMPREF0766_11849"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026375_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="248"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="465" mass="53076" checksum="FC3B1201D25D8B25" modified="2010-10-05" version="1">MILTGLGVILVLSGWLYGSYQNRRDLFLSSAERSMFNVIQEVYQTKINVDDSLRSAQARGRKSFVGYLQEKFPKIDFDSLRKNFEESSGKSSYMQGFRDNATRKGEERNDEGPSQIIPPYLFKDFDFDKEVMDTVCHRLKTTLTDKGIYTDFKVELLQLSREEVSTFRANTKAQKLMWTRPTLVNPDRGQFVVVKFENTWRYLLFGMGWQLLVSIVLVASLVGSFLYLMLTIFRQNKMAQLRKNFVNNMTHELKTPVSTVMAAVEAIQTYGVKDDKAKMELYLQVSRNELQHLSDMIEKVLQMDIDEVKGVNLQYTTFDIADLLERCIRIAKLNFKKEIEIVFDCEKRPVMISADEAHLKNVCSNLLDNAIKYSGEKVLITVALKELAHSVEVSVKDNGKGIAAEYQKDVFDAFFRVPEGNLHEVKGFGLGLSYVKQMITQHGGTVSLISELNKGSIFTISIPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLM2</accession>
    <name>D7VLM2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000230.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11892"/>
    <dbReference type="EnsemblBacteria" id="EFK58495">
        <property type="protein sequence ID" value="EFK58495"/>
        <property type="gene ID" value="HMPREF0766_11892"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3157943_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="48" mass="5769" checksum="3534849DB64ABB41" modified="2010-10-05" version="1">MVFIVKNYSIKHDFDMIRMTGNDSADVLFVLKRENQNENLENRILMQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLQ8</accession>
    <name>D7VLQ8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Efflux ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_11928</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000312.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11928"/>
    <dbReference type="EnsemblBacteria" id="EFK58531">
        <property type="protein sequence ID" value="EFK58531"/>
        <property type="gene ID" value="HMPREF0766_11928"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_1_10"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="302"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="411" mass="45920" checksum="B863FA3CB7AF7841" modified="2010-10-05" version="1">MNLSYFFAKRYLFSKKSVNAINIISMISVIGVLVSSAALVIVLSFYNGMEKLILSMFSTFSPELRIEPAEGKLFSTKNQLFEELRKSKDIKSYSEVLEEKALLQFGNHQFIGKLKGIEPNSLHQHASDSMLYAGEFEIFKEDVSYAIIGANVQANLQIPIVGLRNTMLINSPRKGSTNAVNPADDIIQRGISPRGVLKYQQGFDDLVITPIDFARDALGEYDKVSAIEMYTRQPEKLAEIEKQIQDKLGKGFKVLNREEQNPTLYKTVSTEKWAVFFILTFIGIIAIFNIIGSMTMLVIDKRQDMIILKSLGAENTLIQRIFYNEGMLIALIGSVSGIIIGYVFCFLQDTFGFIRTGEGNNSIIDAYPVDIRLSDFLLVFLTVLLASVLISYLSSLLSVKAIGDLKAESSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLT3</accession>
    <name>D7VLT3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RHS repeat-associated core domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001579.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12187"/>
    <dbReference type="EnsemblBacteria" id="EFK58195">
        <property type="protein sequence ID" value="EFK58195"/>
        <property type="gene ID" value="HMPREF0766_12187"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004466_1_0_10"/>
    <dbReference type="OrthoDB" id="1639867at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045619">
        <property type="entry name" value="DUF6443"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20041">
        <property type="entry name" value="DUF6443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107669" evidence="1">
        <location>
            <begin position="30"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6443" evidence="2">
        <location>
            <begin position="118"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1167" mass="131280" checksum="499CB8BD9D42E2FC" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLX8</accession>
    <name>D7VLX8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferritin</fullName>
            <ecNumber evidence="1">1.16.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ftnB</name>
        <name evidence="3" type="ORF">HMPREF0766_11975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Iron-storage protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 Fe(2+) + 6 H2O + O2 = 12 H(+) + 4 iron(III) oxide-hydroxide</text>
            <dbReference type="Rhea" id="RHEA:11972"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:78619"/>
            <dbReference type="EC" id="1.16.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ferritin family. Prokaryotic subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.2" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK57983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001089.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11975"/>
    <dbReference type="EnsemblBacteria" id="EFK57983">
        <property type="protein sequence ID" value="EFK57983"/>
        <property type="gene ID" value="HMPREF0766_11975"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1528">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065681_1_0_10"/>
    <dbReference type="OrthoDB" id="1890523at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01055">
        <property type="entry name" value="Nonheme_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041719">
        <property type="entry name" value="Ferritin_prok"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="PTHR11431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0409">Iron storage</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="183" mass="20727" checksum="C9B3931B2DC5D45C" modified="2010-10-05" version="1">MNTNRLSKEMQSALIAQMTKEASAAQIYLSLGIWADDQGYGGIANFLFRHANEERNHMTKFMEYILERGGKPRVEAIPAPPAEPKSLTECFNRVFQHEVDNTEAIYNIVNLSMKEQDWATWNFAQWFVKEQIEEEKLALELIDKLKIAGGDKATDESLFNLDKALGEADDEVSLAREATAENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLZ4</accession>
    <name>D7VLZ4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK57999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11991"/>
    <dbReference type="EnsemblBacteria" id="EFK57999">
        <property type="protein sequence ID" value="EFK57999"/>
        <property type="gene ID" value="HMPREF0766_11991"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3189165_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="46" mass="5363" checksum="1E18DCD74A2843A7" modified="2010-10-05" version="1">MEHANNTLYTQLFLRLALALLFFLLLLIVLDYGLQQILSGEIWMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM14</accession>
    <name>D7VM14_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase, S9A/B/C family, catalytic domain protein</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12011</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001200.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12011"/>
    <dbReference type="EnsemblBacteria" id="EFK58019">
        <property type="protein sequence ID" value="EFK58019"/>
        <property type="gene ID" value="HMPREF0766_12011"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014586_0_0_10"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107404" evidence="2">
        <location>
            <begin position="20"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="736"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="929" mass="105645" checksum="6A902ECEA91F5BAD" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM20</accession>
    <name>D7VM20_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001217.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK58025">
        <property type="protein sequence ID" value="EFK58025"/>
        <property type="gene ID" value="HMPREF0766_12017"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2669194_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="75" mass="8386" checksum="71EE8025F25A2D49" modified="2010-10-05" version="1">MYEYREEEIHKISADGKFTVPVSYFSDSTSTISFLILKFNASKQGNVNPALVKGSQINVKGSIKMTKDFDHEGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMD6</accession>
    <name>D7VMD6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ecotin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I11 (ecotin) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001463.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12133"/>
    <dbReference type="EnsemblBacteria" id="EFK58141">
        <property type="protein sequence ID" value="EFK58141"/>
        <property type="gene ID" value="HMPREF0766_12133"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111565_0_0_10"/>
    <dbReference type="OrthoDB" id="1603172at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036198">
        <property type="entry name" value="Ecotin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005658">
        <property type="entry name" value="Prot_inh_ecotin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35890">
        <property type="entry name" value="PTHR35890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03974">
        <property type="entry name" value="Ecotin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49772">
        <property type="entry name" value="SSF49772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107433" evidence="2">
        <location>
            <begin position="22"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="160" mass="18170" checksum="2506634819F987BB" modified="2010-10-05" version="1">MIKFFKLLTVLISLGTASVYAQQSVNSSVSMFPKAEKGQVQYIIDVPHSDKDNLKKIEFFAGKIMETDGCNSYGLAGQFEEKDLQGWGYNYYVFTTNGSVRSTMMACPDAKKIQQFVYSESKLARYNGRLPIVIYAPEGYEIRYKIYTTNEETFVGKIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VME0</accession>
    <name>D7VME0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001468.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12137"/>
    <dbReference type="EnsemblBacteria" id="EFK58145">
        <property type="protein sequence ID" value="EFK58145"/>
        <property type="gene ID" value="HMPREF0766_12137"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032Z66">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130255_1_0_10"/>
    <dbReference type="OrthoDB" id="1695377at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031977">
        <property type="entry name" value="DUF4783"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16022">
        <property type="entry name" value="DUF4783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107053" evidence="1">
        <location>
            <begin position="20"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="134" mass="15488" checksum="AF26E17D3F7EBC45" modified="2010-10-05" version="1">MKKWIIVATIFLSFLSSFARGWRQDIAENILSSLRAGNSKDLAKNFASTVSVAVKQEDGVYSKFQAELILNEFFRQNKPSSARIMQKMNSNSSNAYYVFSLKTQREQYRVFTKLIENNDVLYISEIRFEPVPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMH8</accession>
    <name>D7VMH8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase C</fullName>
            <ecNumber evidence="2">3.1.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_12175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial phospholipase C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.3" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001558.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12175"/>
    <dbReference type="EnsemblBacteria" id="EFK58183">
        <property type="protein sequence ID" value="EFK58183"/>
        <property type="gene ID" value="HMPREF0766_12175"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008770_1_0_10"/>
    <dbReference type="OrthoDB" id="250274at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034480">
        <property type="term" value="F:phosphatidylcholine phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017767">
        <property type="entry name" value="Bact_PC-PLC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008475">
        <property type="entry name" value="PLipase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05506">
        <property type="entry name" value="DUF756"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03396">
        <property type="entry name" value="PC_PLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF756" evidence="4">
        <location>
            <begin position="633"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="DUF756" evidence="4">
        <location>
            <begin position="756"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="277"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="840" mass="95397" checksum="903C790B59697998" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMS6</accession>
    <name>D7VMS6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57223">
        <property type="protein sequence ID" value="EFK57223"/>
        <property type="gene ID" value="HMPREF0766_12296"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3157937_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="48" mass="6100" checksum="516B53FC71FA8A44" modified="2010-10-05" version="1">MLFRSASAKIRLIFDFCKFYLKIIIKRLKEHFKRFRDNYRPCLFELQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMT2</accession>
    <name>D7VMT2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">rplA</name>
        <name evidence="10" type="ORF">HMPREF0766_12302</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12302"/>
    <dbReference type="EnsemblBacteria" id="EFK57229">
        <property type="protein sequence ID" value="EFK57229"/>
        <property type="gene ID" value="HMPREF0766_12302"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0081">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK57229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="244" mass="26131" checksum="E48E38C8316CA99D" modified="2010-10-05" version="1">MEQLINEISLRKVARLTKNQKAALSKIEAGKAYSLKEASALVKEISLTKFDASVDIDVRLGVDPRKANQMVRGIATLPHGTGKTVRVLVLCTPDKEEEAKAAGADFVGLDDYISKIEGGWTDVDIIITMPSVMAKVGKLGRILGPRNLMPNPKTGTVTTEVGKAVTDVKGGKIDFKVDKTGIIHTSIGKASFDADKIYDNALEVLQTISRLKPSAAKGTYFKSIHISSTMSPGIHVETKSVAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMT3</accession>
    <name>D7VMT3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplJ</name>
        <name evidence="3" type="ORF">HMPREF0766_12303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992783.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12303"/>
    <dbReference type="EnsemblBacteria" id="EFK57230">
        <property type="protein sequence ID" value="EFK57230"/>
        <property type="gene ID" value="HMPREF0766_12303"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092227_3_0_10"/>
    <dbReference type="OrthoDB" id="1470978at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="172" mass="18491" checksum="7935249F6CD70D11" modified="2010-10-05" version="1">MRKEEKQEIVLALAEQIKSYGNFYIADTADLSVEKVNGIRRKCFESGIEIKVVKNSLIKKALIEAGVDSEEIFGTLKGASTLMFSEVGNAPAKLIKQLRKEGDKPLLKAAYIDSAAFVGDGQLNALVNLKSKNELIADVIALLESPAKNVISALQSGGNTISGLVKALEERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMY8</accession>
    <name>D7VMY8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">atpB</name>
        <name evidence="14" type="ORF">HMPREF0766_12358</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cell membrane</location>
            <topology evidence="11 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992876.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12358"/>
    <dbReference type="EnsemblBacteria" id="EFK57285">
        <property type="protein sequence ID" value="EFK57285"/>
        <property type="gene ID" value="HMPREF0766_12358"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041018_0_0_10"/>
    <dbReference type="OrthoDB" id="867266at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045083">
        <property type="entry name" value="ATP_synth_F0_asu_bact/mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410">
        <property type="entry name" value="PTHR11410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107721" description="ATP synthase subunit a" evidence="13">
        <location>
            <begin position="24"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFK57285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="361" mass="40562" checksum="23A44A8B7673DD13" modified="2010-10-05" version="1">MESLRRTLLIFTAVLFTFNPFLAGASEGGDEPKSQSEEIKEYSEHHLQDDYYFSLFADKKADKVYGFPLPVILIDNGLKVFSSAAFDHGHAVVEKDGQYYKLFHNKIYKTDAAGTLTMDEKHHPTNAKPLDFSITKNVVGLLLATLLLFWGFLSLAKTYKKGANTLPKGVGRVLEPLVLYVRDEMAVPNIGSRYKEFMPYLLSVFFLIFLLNLLGLTPLGFNVTGNITVTLCLALFTFFIILFKANKNYWKHIFWMPGVPVPFKIVLAPIELLGMFTKPFSLMLRLFANITAGHSVVMGLIAIVYLFQTQLTVGGSIGVSMLLTLILMLLELLVAFLQAFIFTMLSSLFIGMAVEEHHDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN64</accession>
    <name>D7VN64_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phage tail tape measure protein, TP901 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_12434</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992977.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12434"/>
    <dbReference type="EnsemblBacteria" id="EFK57361">
        <property type="protein sequence ID" value="EFK57361"/>
        <property type="gene ID" value="HMPREF0766_12434"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5283">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_249187_0_0_10"/>
    <dbReference type="OrthoDB" id="417465at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010090">
        <property type="entry name" value="Phage_tape_meas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10145">
        <property type="entry name" value="PhageMin_Tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01760">
        <property type="entry name" value="tape_meas_TP901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="PhageMin_Tail" evidence="4">
        <location>
            <begin position="306"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1232"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="728"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1490" mass="164452" checksum="7F1A1A55A9440E8F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN68</accession>
    <name>D7VN68_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992981.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12438"/>
    <dbReference type="EnsemblBacteria" id="EFK57365">
        <property type="protein sequence ID" value="EFK57365"/>
        <property type="gene ID" value="HMPREF0766_12438"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_921037_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="302" mass="32264" checksum="7D0907F56E7C65B4" modified="2010-10-05" version="1">MADEHVKKKLIELEPYPSDQKIKSSDLIYVWNTDSAKLQKANINQMPFGSGGGGGGVTTLVGSPFKVSLGDDQVTIEGSNTIISDVRLLGKKDYPISTTQLQNATFRKGEVAYNEIDGTVTILDFRLNAGEEVVLYPDGMQGSGGGGGNLQPIMDRLTEIESIVSVFKPTVSGTNNARVWWVGGLPLPAGWEEDAEWRDYLPLAVAPSESGKVYGSNSVTLKSNQQGSFGVKAVSDRSAGSSRNNTIWNLSFLSNGTWRMLTGGSGANVDIGPITVNLSDASTPIDIRPKSKGGMWIKYVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN98</accession>
    <name>D7VN98_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter, major facilitator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_12468</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993019.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12468"/>
    <dbReference type="EnsemblBacteria" id="EFK57395">
        <property type="protein sequence ID" value="EFK57395"/>
        <property type="gene ID" value="HMPREF0766_12468"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_61_0_10"/>
    <dbReference type="OrthoDB" id="1384345at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="390" mass="42883" checksum="E735673C1829FD14" modified="2010-10-05" version="1">MKKYAYIGCLGFIAVITTEFGVIGILPQIATHYNISIDKAGMLLSAFALVIALTGPFMTLLMSRFDRKKVMFGAISIFLFTGIISSISPPFWLLMLVRILPAFLQPVYIATALSVAVAQGEKKNENELMSIVFSGIAIAMVSTVPFATWLASRVSWEYSFMIQAVVSTIALSAIYFLLPDMPVVAKRSYGSQLKILRQPIFIVSTGMNFFMIAGWFATYSYFAEYLNKTKGMDNTMVSYMLFLFGMVGVIANRVAGKMLNKNVTNTTAIFLSGTILIPLLLHFSGTNTFAVIVVIALWGFLYSPSFLNASTYMISSAPQSLEFANSLATSFGNMGITLGTTVGGWIIATRGVQYTPWLTLSFGILSFTMIVLRKWLEKSNSEMGIECSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNF6</accession>
    <name>D7VNF6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">tatA</name>
        <name evidence="9" type="ORF">HMPREF0766_12526</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms a complex with TatC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993094.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12526"/>
    <dbReference type="EnsemblBacteria" id="EFK57453">
        <property type="protein sequence ID" value="EFK57453"/>
        <property type="gene ID" value="HMPREF0766_12526"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086034_6_2_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK57453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="69" mass="7595" checksum="17D859B548648945" modified="2010-10-05" version="1">MLTSGLLFIGTQEIIIIVILVLLLFGGKKIPELMRGLGRGVKEFKDGQREEPTESGNNTNNKENSNNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNH8</accession>
    <name>D7VNH8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993125.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12548"/>
    <dbReference type="EnsemblBacteria" id="EFK57475">
        <property type="protein sequence ID" value="EFK57475"/>
        <property type="gene ID" value="HMPREF0766_12548"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033ASR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2720309_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107383" evidence="1">
        <location>
            <begin position="20"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="72" mass="7311" checksum="FD9293F055CDC29D" modified="2010-10-05" version="1">MKNLFKFGFLGLALTLAFASCGNSSTKTAETADSLGDSIQATTDSIADSLNNVADSVKAKGDSIADSVKAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNS9</accession>
    <name>D7VNS9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Haem_bd domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993272.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12649"/>
    <dbReference type="EnsemblBacteria" id="EFK57576">
        <property type="protein sequence ID" value="EFK57576"/>
        <property type="gene ID" value="HMPREF0766_12649"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120447_1_0_10"/>
    <dbReference type="OrthoDB" id="1935300at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025992">
        <property type="entry name" value="Haem-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14376">
        <property type="entry name" value="Haem_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01235">
        <property type="entry name" value="Haem_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Haem_bd" evidence="1">
        <location>
            <begin position="12"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="151" mass="17429" checksum="A124FC8CC7261DC9" modified="2010-10-05" version="1">MTIKKKIILGLAVVLIAIQFFQPLRNQAVEVPATHIERVYTVPQNVKAILVQSCYDCHSNNTHYPWYSRIQPGAWYMAEHIKKGKEELNFSEFGDYSVRRQRNKFRAMAGQVKDGEMPLSSYTLIHRNAVLSPEDKQVLIAWFGTMEDSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNV1</accession>
    <name>D7VNV1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993305.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12671"/>
    <dbReference type="EnsemblBacteria" id="EFK57598">
        <property type="protein sequence ID" value="EFK57598"/>
        <property type="gene ID" value="HMPREF0766_12671"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZC9E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110577_1_1_10"/>
    <dbReference type="OrthoDB" id="1897239at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015068">
        <property type="entry name" value="DUF1877"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035944">
        <property type="entry name" value="YfbM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08974">
        <property type="entry name" value="DUF1877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111069">
        <property type="entry name" value="SSF111069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="162" mass="18202" checksum="8E471E8EDC6E8254" modified="2010-10-05" version="1">MIANLLRVTTSELEAYLKDSSLLEDSIYNDEADAENLIDIDKSWDGIIFLLTGQGLATAKYNLVRILFSAQIIDEEQDLGYGPAHYLTAEQVAELNGEISAITIADLKQRFNPERMNELEVYPIIWDEGDDAFDYLADGFLTLQNVFADATKNKEAIITFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP38</accession>
    <name>D7VP38_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12758"/>
    <dbReference type="EnsemblBacteria" id="EFK57685">
        <property type="protein sequence ID" value="EFK57685"/>
        <property type="gene ID" value="HMPREF0766_12758"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3030113_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="55" mass="6255" checksum="2B65801FBEEFBB81" modified="2010-10-05" version="1">MYGSDFSIPVKIQNDFGFSQRFVALAAQNKNDGSAKPFLIQKSMYSFQIRFSTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPE0</accession>
    <name>D7VPE0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DinB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DinB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993632.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12860"/>
    <dbReference type="EnsemblBacteria" id="EFK57787">
        <property type="protein sequence ID" value="EFK57787"/>
        <property type="gene ID" value="HMPREF0766_12860"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116635_0_0_10"/>
    <dbReference type="OrthoDB" id="2047691at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007837">
        <property type="entry name" value="DinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05163">
        <property type="entry name" value="DinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="157" mass="18741" checksum="4EAE5C4390589C60" modified="2010-10-05" version="1">MKTNEIISKEELLKHWQGHRSLTRRVIEAFPEKDLFEFKVGPMRPFSLMAQELISIAGPGLKGIVNRVEEPYSEKIDLKTKQEILDEWDKVTRDIDVYFNMIKEEDFHDTFNLFGEYKSPVYENLLYFIDNEIHHRGQGYVYLRALGIQPPPFWERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPG3</accession>
    <name>D7VPG3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993682.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12883"/>
    <dbReference type="ESTHER" id="9sphi-c2fy88">
        <property type="family name" value="Monoglyceridelipase_lysophospholip"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57810">
        <property type="protein sequence ID" value="EFK57810"/>
        <property type="gene ID" value="HMPREF0766_12883"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051796_0_0_10"/>
    <dbReference type="OrthoDB" id="1694750at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="46"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="320" mass="37015" checksum="A76BEE287B02784B" modified="2010-10-05" version="1">MEDQLTSYQADILGSPYQQRTLILKDDYEGKAVATVVRRKSEIVTRQAVLYIHGYIDYFFQTEMAEQFNLHGYDFYALDLRKYGRSYLPHQKLFNVRDLREYDEEIDLTLRLIADEGHHSVILCGHSTGGLTATYYAIRHPHDPLIKGLWTNSPFYDFNVDALSKLIGIPFASSLAKLFPHLRLPNGLNRYYARSLHKDLSGEWDFDLNWKPVQYPYSYAGFIRAVHLAHRAIHNGATLTMPALIMHSHQSKKPKEWNKDVNSSDLVLEVKDIHKYAQKLTGDITIISVENGVHDLVLSAKEVRTKVYEILFSWLKEKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPQ2</accession>
    <name>D7VPQ2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993846.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12972"/>
    <dbReference type="EnsemblBacteria" id="EFK57899">
        <property type="protein sequence ID" value="EFK57899"/>
        <property type="gene ID" value="HMPREF0766_12972"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_640667_0_0_10"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="37"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="426" mass="47367" checksum="C48511070E83378A" modified="2010-10-05" version="1">MNEMNQDRRTFIKQSAVVAASLAAIPHLGYATSAKKIKVGLIGCGGRGTGAASQALAADPQVEITALADIFPDQLEHALTTLREIDAARVHVDDKNKFVGFDAYKKLINSGVDVVLLCSPPNFRPDHLEEAVKAGKHIFCEKPVAVDIPGIHRVSKAVELAKQKKLNIVCGFCFRYSTPNREIIKQVRAGSIGDVKGLSTFRYGGELTFKDRQPSWSDLEFQLRNWLFYTRYSGDMLVEQAIHSVDFMSWVMNDELPKLVTGTGGRQAKPWDKFGNVYDHYAVEYAYAGGLKSYHFSRQQNGTTSRNSVDVMGTQGQVDVKLMSSYEVLGEHPWKFTGRLNNMYQTQHDELFAAIRNGQVINDGDSMTKSTLLGIWGRTAAYTGKAITYDEIMNSQVVLGPHSDEFDWNMKVDQLPIPRPGLTTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPQ6</accession>
    <name>D7VPQ6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleoside transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_12976</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993853.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12976"/>
    <dbReference type="EnsemblBacteria" id="EFK57903">
        <property type="protein sequence ID" value="EFK57903"/>
        <property type="gene ID" value="HMPREF0766_12976"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013133_1_2_10"/>
    <dbReference type="OrthoDB" id="791272at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004740">
        <property type="entry name" value="Nuc_H_symport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03825">
        <property type="entry name" value="Nuc_H_symport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="210"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="416" mass="46517" checksum="EE4A3281131BB37B" modified="2010-10-05" version="1">MDISLRIRLSVMMFLEYVIKGAWFVTLGTYLAKNLQATGLEVANIFSTQSLGAVIAPFFIGFVADRYFNAERVLSVLHLIGAALLFMMYKSASAAEFYPYVFVYFIAYMSSLALTNSISFRHLKDAKKQFPGIRVWGTVGWVFSGVVISYIFHWDSPEEISRGALSYTFLLASCCSLLLAVFSWILPKTPPVARNKEKSFRIADAMGLEALALLKNKGFLVFFLTAVVICIPISFYYQNTNPYLVSVGLPNPTAKMALGQLSEAFCLLLIPFFFARFGYKKMILIGISAWILRYLLFAFGNGDELSYMLITGIVLHGVCYDFMFVVGQIYTDTIAGERYKSSAQGLITVAMYGIGMLIGFWVAGYISDYLKAAYVSDFWWYLWITPAAIAAGCLLIFAVFFKEKRGEADGTGTEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPU6</accession>
    <name>D7VPU6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PepSY domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993907.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13016"/>
    <dbReference type="EnsemblBacteria" id="EFK57943">
        <property type="protein sequence ID" value="EFK57943"/>
        <property type="gene ID" value="HMPREF0766_13016"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031962_2_0_10"/>
    <dbReference type="OrthoDB" id="1656356at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005625">
        <property type="entry name" value="PepSY-ass_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34219">
        <property type="entry name" value="PTHR34219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03929">
        <property type="entry name" value="PepSY_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="393" mass="45404" checksum="95A190FB151BF742" modified="2010-10-05" version="1">MLRSAVLWIHKWMGILSGIVVLSLGITGCLYVFQEELKLLFYPQKYFLEKKHNDAPMPLSTLIAHAQAALPPSHRITRADLYPDPSRTWIFRASKTNENAFGHWNYYSYYDRVFVNPYTGAVTAVEDSKNEFFQLVLQMHLNLLLGKKYGHPIVGYATAVFVLLLISGLILWWPKRWKGKTLKRSLWIDRKAKWKRLNYDLHNVFGFYSLFIGLVIGITGLVFAFPAFEKSYVNFFNHLGTDEIKQNKPTYPLVSGPEASAMDKALYFAIKNYPTADMMSLRLRNEADKPVDIQIRLQKDKTSRFKWYYFDAVTAQIINIKSDDNLSGGEKLRSMNYDLHVGSIGGLPTKILAFFISLFCASLPVTGYILWWQKSSKSNKKYNRRKKRHIQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPX9</accession>
    <name>D7VPX9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OmpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_13033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993940.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13033"/>
    <dbReference type="EnsemblBacteria" id="EFK55830">
        <property type="protein sequence ID" value="EFK55830"/>
        <property type="gene ID" value="HMPREF0766_13033"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014978_0_0_10"/>
    <dbReference type="OrthoDB" id="583204at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005343479" evidence="3">
        <location>
            <begin position="27"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="529"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK55830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="650" mass="72502" checksum="E4B0FB92DFA33717" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ19</accession>
    <name>D7VQ19_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993992.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13073"/>
    <dbReference type="EnsemblBacteria" id="EFK55870">
        <property type="protein sequence ID" value="EFK55870"/>
        <property type="gene ID" value="HMPREF0766_13073"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50335XM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181440_0_0_10"/>
    <dbReference type="OrthoDB" id="1997731at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="89" mass="9986" checksum="564C3DF6AD81E35D" modified="2010-10-05" version="1">MMIGELIAKEELPNYKIIPAPVDHSELLKDKLEGALRLGNAFKSKTTIVFQTEDGPKRIETTIWSVTDKYLQIKSGVLIPLKSVLGIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ46</accession>
    <name>D7VQ46_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative cell division ATP-binding protein FtsE</fullName>
            <ecNumber evidence="5">3.6.3.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpoA</name>
        <name evidence="5" type="ORF">HMPREF0766_13100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.28" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994038.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13100"/>
    <dbReference type="EnsemblBacteria" id="EFK55897">
        <property type="protein sequence ID" value="EFK55897"/>
        <property type="gene ID" value="HMPREF0766_13100"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2884">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_10"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK55897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="226" mass="25128" checksum="71C35181BEAAD75B" modified="2010-10-05" version="1">MIGNTVITLKNVDIYQQKHLVLSNVNLKIDQGEFLYLIGQSGSGKSSLLKIIYGDLYIGNGEGMVAGFDLRKLHDNDVPYLRRKLGIVFQDFHLLNDRTIEKNLEFALKATGWTDKGLIQGRMLDVLEKVGLRSKLKKMPHELSGGEQQRVVIARALLNNPEIILADEPTGNLDPATSEEIVLLLRDIASSGTAVLMATHDYQIIRNMPARILKTSDGALHDNVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ50</accession>
    <name>D7VQ50_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter, dicarboxylate/amino acid:cation Na+/H+ symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gltT</name>
        <name evidence="8" type="ORF">HMPREF0766_13104</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994043.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13104"/>
    <dbReference type="EnsemblBacteria" id="EFK55901">
        <property type="protein sequence ID" value="EFK55901"/>
        <property type="gene ID" value="HMPREF0766_13104"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019375_7_0_10"/>
    <dbReference type="OrthoDB" id="781228at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046942">
        <property type="term" value="P:carboxylic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK55901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="478" mass="52508" checksum="D2F74C9B57F60C32" modified="2010-10-05" version="1">MFKSKMGLLTFAVLSIATILTVIYEFNWVSISPDVMMVVRWVVGVVLVINAFQRKNLTSWILTCMILGIFVGIDFPNFAIALQPLSKGFIKLVKTIVGPILFATLVYGIAGHSDLKQVGRMAWKSMLYFFCATTCAIFIGLAAINITHAGVGIDIQHMPHEELPVKKENPDQNSLDHLPENVHGVFKFTAFFRDLFPENIVKSVYENQVLQIVVFSVLFGIGLALVEEKKRKPLVNFTESLSEAMFKFTNIIMYFAPVGVGAAMAYTVGHLGVDILKNLFMLLATLYMALIFFLLLVLLPVALYLKIPVMKFINAIKEPVSIAFATTSSDAALPKAMSAMERFGVPRRIVSFVIPTGYSFNLDGTSLYLSLAAIFVAQAAGMHLSFGQQLMIAFTLMITSKGVAAVPRASLIILIATADQFGLPVFVIAAILGIDELMDMARTSVNVIGNCLATVVVAKWEGEFDEEAPYRTDDPDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ70</accession>
    <name>D7VQ70_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994073.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13124"/>
    <dbReference type="EnsemblBacteria" id="EFK55921">
        <property type="protein sequence ID" value="EFK55921"/>
        <property type="gene ID" value="HMPREF0766_13124"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_0_10"/>
    <dbReference type="OrthoDB" id="1204073at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="239" mass="26969" checksum="1431AD29AF06573B" modified="2010-10-05" version="1">MKKIEGLIFDYGGTLDSNGQHWAAVLWSSYQKYEAGISREQFDQAYVFAERKMATHPIITEDFNFLQVLQAKLSVQFEYLVSQDIRLDNQLADLIANDGYELAKNNVLRVTESLNRLHEKYPVVMVSNFYGNLTSVLRDFGIYNCFDKIIESSVVGVRKPDPAIYALGVDVIGLPAADCLVIGDSYSKDMVPAKACGCQTLWLKGEGWKGDDEGETKDADYTFYDIGDLERIITNWESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ90</accession>
    <name>D7VQ90_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994101.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK55941">
        <property type="protein sequence ID" value="EFK55941"/>
        <property type="gene ID" value="HMPREF0766_13144"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032R41">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1303304_0_0_10"/>
    <dbReference type="OrthoDB" id="1194305at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="213" mass="24789" checksum="FE4B33FFCDC9BABC" modified="2010-10-05" version="1">MEIQVNELFFLVFAALGYVILQSLFILGVRIAAKGGTEVLPDGRDKDSEMILYPLFKYLSRVRHVKVYYSGEQWDILFGKLQQKLKNETLVNSGNSLIYDNSSPESEERIRQGLKEIDEKISMETDGKGVIRCYKTDEEYVVNKYFRKPVIQCPICMASYWSVFGYWIPMFYFFGFEIWIVYFGILNICAVSCVNWLLWMRGSAHEALIMKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQG1</accession>
    <name>D7VQG1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RHS repeat-associated core domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994268.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13215"/>
    <dbReference type="EnsemblBacteria" id="EFK56012">
        <property type="protein sequence ID" value="EFK56012"/>
        <property type="gene ID" value="HMPREF0766_13215"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_261521_0_0_10"/>
    <dbReference type="OrthoDB" id="1639867at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1300" mass="142725" checksum="276E384E5E1DD69B" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQI8</accession>
    <name>D7VQI8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter, major facilitator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13242"/>
    <dbReference type="EnsemblBacteria" id="EFK56039">
        <property type="protein sequence ID" value="EFK56039"/>
        <property type="gene ID" value="HMPREF0766_13242"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035309_1_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="407" mass="43280" checksum="A4B4AF6D9B26D647" modified="2010-10-05" version="1">MKICIYLQNKTIKMMEMKLKTTKAITATKAIFLVCGLAISSWAPMVPYAKDRLGINDADLGILLLLLGAGAIAMMPVSGILSHKYGTRRVILVAALATALILPLLLIISSPVWMGVSLFLFGGALGTVDVAMNAHGVQVQNSAEKPIMSSLHGLFSVGGLFGSLGLGFLIKMGLPPITAIVAICILLICIVSWNFRFLFDMHTEKELIVKFAAAPDEKKKTGVSWLQASILFLGLMCFITFLSEGAMLDWSAIFLRENKGVAPELAGVGYAAFSVAMATMRLLGDRIISRLDGKTVVVGGSVIAAAGIFIAVAASWLPLTLFGFILLGIGAANIVPVFFSEGGRIRNVPATIAIPVISTMGYAGQLAGPAMLGYISFRFSIDTAFLLIAFLILIVALTYGLRKTSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQN6</accession>
    <name>D7VQN6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994403.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13290"/>
    <dbReference type="EnsemblBacteria" id="EFK56087">
        <property type="protein sequence ID" value="EFK56087"/>
        <property type="gene ID" value="HMPREF0766_13290"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_5_2_10"/>
    <dbReference type="OrthoDB" id="2057904at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="25"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="126" mass="14563" checksum="763857A62A7B43DB" modified="2010-10-05" version="1">MGNNTNTENESIAELKNKLLKQNSCDLSAVFKIIGGKWKILLIKSILHGCPKRFGELRRELEDLAQTTLTTQLRELERDGIISRKIYAETPPRVEYKLTPLGLTLIPVVQSLEDWWHQYNEQRTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQT0</accession>
    <name>D7VQT0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13334"/>
    <dbReference type="EnsemblBacteria" id="EFK56131">
        <property type="protein sequence ID" value="EFK56131"/>
        <property type="gene ID" value="HMPREF0766_13334"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3222231_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="44" mass="4927" checksum="BA94B9010016552B" modified="2010-10-05" version="1">MILTPAPVIFTDRSPGFAEFLPVLIYSLFPGNTFYPTFDSNNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQT5</accession>
    <name>D7VQT5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13339"/>
    <dbReference type="EnsemblBacteria" id="EFK56136">
        <property type="protein sequence ID" value="EFK56136"/>
        <property type="gene ID" value="HMPREF0766_13339"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069593_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="182"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="324" mass="36869" checksum="D5F196866A7CF166" modified="2010-10-05" version="1">MLKDYYMEFFNKTGKMALGSRLRLLTAKVTEDAAKVYELYDMDFSPKWFPVFFMLAEEGEKTISEIANEIGHSQPSVTKIIREMGAAGLIADNLDSDDKRLNVVGLTEKGKELSKKISVQCEDVEAAVESVMKEARHDLWAAIEEWEVLLAQKSLLRRVQEQRKIRESKAVQIVRYEPKYQSVFKSLNEEWISRYFEMEETDYKALDNPQEYILDKGGAIFVALYNGKPLGVCALIRMNDAEYDYEMAKMAVSPAAQGKNIGLLLGQEIIREARNLGAGSIYLESNTILEPAINLYYKLGFEKIIGHATPYKRCNIQMALALDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR52</accession>
    <name>D7VR52_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994620.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13456"/>
    <dbReference type="EnsemblBacteria" id="EFK56253">
        <property type="protein sequence ID" value="EFK56253"/>
        <property type="gene ID" value="HMPREF0766_13456"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4898">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133735_0_0_10"/>
    <dbReference type="OrthoDB" id="1890756at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023204">
        <property type="entry name" value="SP1917_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014580">
        <property type="entry name" value="UCP033199"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09966">
        <property type="entry name" value="DUF2200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033199">
        <property type="entry name" value="UCP033199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="116" mass="13439" checksum="676A2AA7413AF142" modified="2010-10-05" version="1">MDNSRVYKMSFAGVYPHYIQKAEKKGRTKAEVDEIICWLTGYTAESLQKQIDNKTNFEIFFAEAPQINPNVSKISGVICGYRVEEIEDKLMQQVRYLDKLIDELAKGKAMEKILRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR53</accession>
    <name>D7VR53_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMI1_KNR4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994621.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13457"/>
    <dbReference type="EnsemblBacteria" id="EFK56254">
        <property type="protein sequence ID" value="EFK56254"/>
        <property type="gene ID" value="HMPREF0766_13457"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082074_0_0_10"/>
    <dbReference type="OrthoDB" id="1975953at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="1">
        <location>
            <begin position="35"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="222" mass="25571" checksum="49BCBCEF9854FCCE" modified="2010-10-05" version="1">MQIERIKTKLQQLKESDTDLELFGAESHMYTLHAPLSIEEIRVFESENEVKLPEDYVLFLTQMGNGGAGPFYGIFPLSESLINLSDNAGNVTYFNLSKPFPHTEAWNVEEELAELYDRIEEAYEAGDEELEEKLFDEKWDLIGAEEHDYGRLYIADYGCGVYISLIVNGDEKGNIWTDDRTNDAGLYPSVELGNTERIRFLDWYERWLDNSLEELNSSANKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR72</accession>
    <name>D7VR72_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_13476</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13476"/>
    <dbReference type="EnsemblBacteria" id="EFK56273">
        <property type="protein sequence ID" value="EFK56273"/>
        <property type="gene ID" value="HMPREF0766_13476"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_2_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="140"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="424"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK56273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1022" mass="113187" checksum="C6674B35A960CB3D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR81</accession>
    <name>D7VR81_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994658.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13485"/>
    <dbReference type="EnsemblBacteria" id="EFK56282">
        <property type="protein sequence ID" value="EFK56282"/>
        <property type="gene ID" value="HMPREF0766_13485"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1626017_0_0_10"/>
    <dbReference type="OrthoDB" id="2155549at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107187" evidence="1">
        <location>
            <begin position="19"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="165" mass="18847" checksum="AE8D13094C7E8502" modified="2010-10-05" version="1">MKKAIIFLLAMTLLIDYAVSQQKDPNPGFAEFNRSFSKNFKYPFQLEDRCISTVTLMMVTFRSDGSVDLIEFSDSVLDQFKNEFFKVKDKIDFKSVFNDIININQENKVVVIPIFIESEKTGPLGCESNIIASDLKNLYNFSGKPISGNYYLYSSLYIINAVVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRA6</accession>
    <name>D7VRA6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pseudouridine synthase, RluA family</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rluA</name>
        <name evidence="3" type="ORF">HMPREF0766_13510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994692.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13510"/>
    <dbReference type="EnsemblBacteria" id="EFK56307">
        <property type="protein sequence ID" value="EFK56307"/>
        <property type="gene ID" value="HMPREF0766_13510"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037416_0_0_10"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="2">
        <location>
            <begin position="366"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="560" mass="63751" checksum="6113D1AC5BCCC4D8" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRA7</accession>
    <name>D7VRA7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, aldo/keto reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mocA</name>
        <name evidence="2" type="ORF">HMPREF0766_13511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13511"/>
    <dbReference type="EnsemblBacteria" id="EFK56308">
        <property type="protein sequence ID" value="EFK56308"/>
        <property type="gene ID" value="HMPREF0766_13511"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="24"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="328" mass="37138" checksum="FC53A2E9F805076B" modified="2010-10-05" version="1">MYYNKAIAYMRKVRLGQSDLEIVPLVFGGNVFGWTLDEKQSFDILDAYLDKGFDAVDTSNQYSHWVPGNTGGESETIIGNWLKKNGNRDKIVLMTKVGGTFPGNPTPNTSKQHILEQVDVSLKRLQTDYIDLYQTHYDDESIPVEETLEAYEQLVKAGKVRWIGTSNMSAQRVLESIEVSEQQHWPRYQTLQPEYNLFSREKYETQYEQLSVEQQLGVLTYYSLASGFLTGKYKSDADFNQSARSEGVKKQYWNERGQRIVAALEEVADAYKTTSTAVALAWLIARPSVAAPIVSATKESHLEPFVSAVQLQLSPESMEKLDAASDWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRF2</accession>
    <name>D7VRF2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13556"/>
    <dbReference type="EnsemblBacteria" id="EFK56353">
        <property type="protein sequence ID" value="EFK56353"/>
        <property type="gene ID" value="HMPREF0766_13556"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_9_2_10"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="197" mass="22903" checksum="AB7B60F49E8389C9" modified="2010-10-05" version="1">MYLPMEHPTAEKIKEIFDPFYKADIHIWTEFAKCVQLRTFEKNEIIKDYHKTERYINILVSGSAAHFVLSGEKEVCINLYYEKQIFSDYLSFLMQSSTVIKTLALEASIIWSINFADLHALYLRSSTGIFIGKAISDAMFIRKQSEQINLLTLSPTERYLKLIKERPEVFQRTSLKIICSYLGITAESLSRIRKKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRH1</accession>
    <name>D7VRH1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-N-acetylglucosamine 4-epimerase</fullName>
            <ecNumber evidence="2">5.1.3.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gne</name>
        <name evidence="2" type="ORF">HMPREF0766_13575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.7" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13575"/>
    <dbReference type="EnsemblBacteria" id="EFK56372">
        <property type="protein sequence ID" value="EFK56372"/>
        <property type="gene ID" value="HMPREF0766_13575"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094967_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003974">
        <property type="term" value="F:UDP-N-acetylglucosamine 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="256" mass="29112" checksum="854EB35DAEA6DA40" modified="2010-10-05" version="1">MKIVIIGGSGFVGTQLIDLLLKTTNYQIVNVDKNESKRFADITVLTNILDKELLCNRLSGSDIVILLAAEHRDDVTPTSLYYDVNVQGMKNTLQAMKTNGIKRIIFTSSVAIYGLNKANPDESFSADPFNHYGKSKWQAEQVLQEWYKSHSDWNINIVRPTVIFGEGNRGNVYNLLYQIASGKFMMIGKGNNQKSMSYIGNIIAFIKFVPVHPQLHYKSKHTIYKSHPLRHLFWLILPVPLSRWLLPAQILPLYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRJ0</accession>
    <name>D7VRJ0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
            <ecNumber evidence="2">2.3.1.57</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.57" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994790.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13594"/>
    <dbReference type="EnsemblBacteria" id="EFK56391">
        <property type="protein sequence ID" value="EFK56391"/>
        <property type="gene ID" value="HMPREF0766_13594"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_41_1_10"/>
    <dbReference type="OrthoDB" id="2055010at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004145">
        <property type="term" value="F:diamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039533">
        <property type="entry name" value="Satl1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF60">
        <property type="entry name" value="PTHR10545:SF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="150" mass="17250" checksum="FE9E3713606BC6E9" modified="2010-10-05" version="1">MQEVIIREAVKTDCPAMLELIKELALFEKAPEQVTVTMEEFEESGFGNNPVWGAFVAEVSGNIVGISLYYIRYSTWKGRRLYLEDLIVTEQMRGTGIGKKLLDQTVEYSKSKGYSGMMWQVLDWNTPAIEFYKKYQATFDGEWLNVSINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRJ5</accession>
    <name>D7VRJ5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994799.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13599"/>
    <dbReference type="EnsemblBacteria" id="EFK56396">
        <property type="protein sequence ID" value="EFK56396"/>
        <property type="gene ID" value="HMPREF0766_13599"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072573_10_3_10"/>
    <dbReference type="OrthoDB" id="1930882at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107202" evidence="1">
        <location>
            <begin position="28"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="89"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="202" mass="21875" checksum="961A9919E5C996BC" modified="2010-10-05" version="1">MSFNICQSAFYILLILVFSHAPRIAFAQEEPARTLDIRILESIAETRTPAQNATFHFISDSHNYMQIAIPAGLFIAGAISDDKQMRQNAGYVISSTAVTALLNIGLKQVFKRSRPFKKYNNFTALSTPGSFSFPSGHTSAAFSTATALSHAYPKWYVIAPAMLWAGSVGYSRMYLGVHYTSDVAAGAALGAGTALGMGFMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRP2</accession>
    <name>D7VRP2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13646"/>
    <dbReference type="EnsemblBacteria" id="EFK56443">
        <property type="protein sequence ID" value="EFK56443"/>
        <property type="gene ID" value="HMPREF0766_13646"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZEFM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2208374_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="107" mass="11947" checksum="393149C67720CA30" modified="2010-10-05" version="1">MNTTHERKANQNYPQAPLRPVTREIQTENHCHRVISSDTTTCANTTPINKVKKDAKNYTAPKITTIRIEMENGIAAGSATAIPASTNKSVDETWDNQNMTSDSPIYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRV3</accession>
    <name>D7VRV3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chorismate binding enzyme</fullName>
            <ecNumber evidence="2">4.1.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trpE</name>
        <name evidence="2" type="ORF">HMPREF0766_13707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995067.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13707"/>
    <dbReference type="EnsemblBacteria" id="EFK56504">
        <property type="protein sequence ID" value="EFK56504"/>
        <property type="gene ID" value="HMPREF0766_13707"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_1_1_10"/>
    <dbReference type="OrthoDB" id="1786019at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="159"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="428" mass="48167" checksum="B142091463470AF1" modified="2010-10-05" version="1">MRIEDIHSIDSSGKFHQKALQWAMQFDEICFFNSNQSADEWSSFDCCLAVKAVSQFVADGTDTFLRAQHFIDQHAGKFIPGFLSYDLKNEIEDLTTDKADLLQFPLAYFFVPAVVITIKNGSVYIEAEAPEQILKEIVSQQYLPEAFKFADTIKARWNKDEYLHAFGRIQSHIQHGDLYEANLCQEFYAEDAFLDPFSVYQQLSEVSPTPFSAFFRMGDHYILSASPERFMAKRGDLLISQPIKGTAPRGATAAEDERIVRQLQDSKKEIAENVMIVDLVRNDLTRSAVKGSVKADRLFEIQSFRQVHQMVSTITCQKSADVTDLEAIKNTFPAGSMTGAPKIAAMKHCEEIENTRRGLYSGAIGYFAQNGDFDFNVVIRTLLYNASSHYISFHTGGAITNQADGEQEYEECLLKAKSLLDALHTSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSM2</accession>
    <name>D7VSM2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995641.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13976"/>
    <dbReference type="EnsemblBacteria" id="EFK56773">
        <property type="protein sequence ID" value="EFK56773"/>
        <property type="gene ID" value="HMPREF0766_13976"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132888_0_2_10"/>
    <dbReference type="OrthoDB" id="1872172at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PTHR31435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="103" mass="11635" checksum="D59467CD0BB0027D" modified="2010-10-05" version="1">MKEEFLTIPLVKNETDHQYEITIDGSKAFITYRENPAMITLLHTEVEPALQGNGASTAVIEKTLDAIEQSGKKLNPLCPLVVAYIKRHPEWKRIVTEQSKSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSN7</accession>
    <name>D7VSN7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter, major facilitator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_13991</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13991"/>
    <dbReference type="EnsemblBacteria" id="EFK56788">
        <property type="protein sequence ID" value="EFK56788"/>
        <property type="gene ID" value="HMPREF0766_13991"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_61_2_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="32"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="422" mass="45639" checksum="12AC19B09B06077A" modified="2010-10-05" version="1">MFKQYFNKFMTKNIPKECTFARKLLRYKMNKGLIALAFGGLAIGMTEFTMMGILPDIAKDLKIEIPVAANLIAFYALGVVVGAPTLVAFSSKYSPKSVLLFLMLLFFIFNGLFAISPDYNTLLLTRFVSGLPHGAFFGVGSVVAANLAKKGKEAQAISVMFTGMTIANLAGVPIGTYIGHHFSWRITYAIISSLGLLTFLTLSIWLPRLKANKDSNILSQISYFKRWYSWLIIAIISIGTGGLFAWISYIAPLVTKVSGLDPDRVPYIMVLVGLGMFFGNLLGGKLADSILPTKASIASFAAMAVCLVILFFVSHIDWLAYVMAFITGMISFTIGPCLQMMLINNAKGAETFAAAAGQAAFNIGNTFGAFFGAIPITTGLAYNYPSLVGAGMASIGALLTFVFLKTYVLKKKDVAEKSEIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSR3</accession>
    <name>D7VSR3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone deacetylase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995734.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14017"/>
    <dbReference type="EnsemblBacteria" id="EFK56814">
        <property type="protein sequence ID" value="EFK56814"/>
        <property type="gene ID" value="HMPREF0766_14017"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0123">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_1_0_10"/>
    <dbReference type="OrthoDB" id="1443295at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016575">
        <property type="term" value="P:histone deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09993">
        <property type="entry name" value="HDAC_classIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044150">
        <property type="entry name" value="HDAC_classIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="2">
        <location>
            <begin position="69"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="334" mass="37765" checksum="82B235E22B323064" modified="2010-10-05" version="1">MLNFISKSNISIGFRGSRATTFLYLRHQIENFVLLKIAFHNAYIHPLREGHRFPMLKYELIPMQLIHEGLVSKDSFFEPELVSEEIACLAHDESYVRDLFELTLDARMIRRIGFPLTDSLIRRERLIVDGTIRTALFAIQYGIAFNVAGGTHHAGYAYGEGFCLLNDQAIAAAYLLAEQKAHKILIIDLDVHQGNGTANIFKGSKAVFTFSMHGAKNFPFIKEQSHLDISLEDGITDKNYLSQLTTVLPDLFEKVAPDFVFYQAGVDVLATDKLGKLKLSPEACKERDYIVLSLCRQLDIPVQVSMGGGYSEHIRDIVNAHIQTYRTAIELYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSX6</accession>
    <name>D7VSX6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pstC</name>
        <name evidence="11" type="ORF">HMPREF0766_14080</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995871.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14080"/>
    <dbReference type="EnsemblBacteria" id="EFK56877">
        <property type="protein sequence ID" value="EFK56877"/>
        <property type="gene ID" value="HMPREF0766_14080"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_1_0_10"/>
    <dbReference type="OrthoDB" id="1325025at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="72"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK56877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="296" mass="31845" checksum="CD3E810DD3A25203" modified="2010-10-05" version="1">MRFKKRLLIDHLFKIIFKSTGFLVLALLGGIFFMLIYNAFAFFADVKPLDFITGMEWNPTAHDPAYGILPLIVSTSLVSFGAMAIAIPLGICTAAFISEYASERVKNILKPTIEMLAAIPSVVIGFLGIVVLGPEIASLAGLSNGLNALNGAILLAIMALPTIITVSEDAIHAIPKTYKEASYAMGANKWQTLIKITIPAAAPGIIAAVMLGVGRAIGETMTVLMATGNASSFPTGFFDSMKTITATIAIEMGEVPYQTTHYFGLFAIATVLFFMTMIANLVGEFFINRFRKYHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSY0</accession>
    <name>D7VSY0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0766_14084</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995875.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14084"/>
    <dbReference type="EnsemblBacteria" id="EFK56881">
        <property type="protein sequence ID" value="EFK56881"/>
        <property type="gene ID" value="HMPREF0766_14084"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013529_0_0_10"/>
    <dbReference type="OrthoDB" id="15185at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107262" evidence="6">
        <location>
            <begin position="24"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="136"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="335"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK56881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="925" mass="103526" checksum="E4D939294E25C925" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT16</accession>
    <name>D7VT16_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Site-specific recombinase, phage integrase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_14120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995959.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14120"/>
    <dbReference type="EnsemblBacteria" id="EFK56917">
        <property type="protein sequence ID" value="EFK56917"/>
        <property type="gene ID" value="HMPREF0766_14120"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033139_2_0_10"/>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035386">
        <property type="entry name" value="Arm-DNA-bind_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025269">
        <property type="entry name" value="SAM-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17293">
        <property type="entry name" value="Arm-DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13102">
        <property type="entry name" value="Phage_int_SAM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="224"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="416" mass="48413" checksum="A4C91678B6C10E87" modified="2010-10-05" version="1">MEQTKKSTFKLLFYLKKNELKKNGNAPVMARITIDGTPKTFGTKLEINPNSWDLKHGRVQGKSATALSINQKLDNIRGRIDKIYEDMLKHEGFATAQKVKLSFLGVGVMDDAILKVFNDQNVEFKRLVDKEERSQGTYNKYITVYNHLTEFIKERYHREDMAFRELTADFIREFDFYLRYDKQCAHNTVWIYTMPVIALAELAIKKGLIRDNPFEDYEISMEETDRGYILKEDVEKLMMCQVPHKRYELVKDIFIFSCFTGLAYADIKKLTRSNIQSFFDGHQWIISRRKKSDVASNVRLMEIPKRIIEKYQGTTRNEFIFPVPTNATCNTHIGKLVEKAEIITEQKVTFHTARHTFGTMFLTEGVPLESLSKMMGHKNISTTQIYAKITSQKISKDMDLVTPKFKAMEEAFMMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTD6</accession>
    <name>D7VTD6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5623 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996266.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57037">
        <property type="protein sequence ID" value="EFK57037"/>
        <property type="gene ID" value="HMPREF0766_14240"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_694276_0_0_10"/>
    <dbReference type="OrthoDB" id="731923at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040531">
        <property type="entry name" value="DUF5623"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18536">
        <property type="entry name" value="DUF5623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5623" evidence="2">
        <location>
            <begin position="85"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="397" mass="45753" checksum="F7E8089307AFC401" modified="2010-10-05" version="1">MTQKTKEGEVEKIKRNAKKIKKQMGIPHHQALDMSAIEQGYSNFRNLLNSFQPKEKDKRNRMEVTNSLPRPLTFPYKTLGSPNGARRPNAKVPVKIHQELGRVLKELYSSLEFNKKGHKAVSIIKSTLDDWIQLEYTSKTELKDELYFTIYYGDTDYPSDPWPTDKRKMELEKLVEVCRKLLKNSYPSCSPIHSLNKRLDQVLKAIHNWPLNKKVKGLKEVKGQIAKGTLIYLKKNQRKPAILLSHDTVNNLIYCYEDAGSAVLAREEITVARDQSKIKKFHPMRLSLPYGKWFCENGAEVLFNRDYIPIWMKDKNGKVHQIDPDTNVVNVDNPVFYFNDGSTPWGGNQSTFVKCKNILLSWNVSDRTSLLLKALGDSVIKGNANNLKFRKRTNIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTG2</accession>
    <name>D7VTG2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein</fullName>
            <ecNumber evidence="5">2.7.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_14266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996337.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14266"/>
    <dbReference type="EnsemblBacteria" id="EFK57063">
        <property type="protein sequence ID" value="EFK57063"/>
        <property type="gene ID" value="HMPREF0766_14266"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_10"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="150"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="361" mass="41558" checksum="055FD905887FDF37" modified="2010-10-05" version="1">MQRELIILYIDDEVNNLIGFKANFRYNYTVLTASNTTEAREILLANPDIRIIFCDQRMPEELGVDFFHRIKKDFPKPIRILLTAYADMETVIDAVNKGHIFRFVRKPWVEEDIISAVEEADKFYIANSMLEIKNEELQKAYDELDKFAYSVSHDLRDPLTGVLSAVRLASEFDNIDRIHELLGLMDDSLISLDAYIDSLRDYYLLRRGELFLSDIDFRELFGNIAQFYKMYTQNKDVAFKIAVNQDYIFKSDKAILELILHNLLSNAFKYQRKELENKIVNLSVDVTETEATITVIDNGIGISSEHISDIFKLFFRGSDQAKGMGFGLYNVQNALLKLKGTIDVKSDLGFGTTFKVVIPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTH4</accession>
    <name>D7VTH4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoate--protein ligase</fullName>
            <ecNumber evidence="4">6.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lplA</name>
        <name evidence="9" type="ORF">HMPREF0766_14278</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10500"/>
            <dbReference type="Rhea" id="RHEA-COMP:10502"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.20" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996372.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14278"/>
    <dbReference type="EnsemblBacteria" id="EFK57075">
        <property type="protein sequence ID" value="EFK57075"/>
        <property type="gene ID" value="HMPREF0766_14278"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022986_0_2_10"/>
    <dbReference type="OrthoDB" id="871298at2"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016979">
        <property type="term" value="F:lipoate-protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019491">
        <property type="entry name" value="Lipoate_protein_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="PTHR12561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10437">
        <property type="entry name" value="Lip_prot_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00545">
        <property type="entry name" value="lipoyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="8">
        <location>
            <begin position="25"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK57075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="327" mass="37224" checksum="BF824ABE1E110071" modified="2010-10-05" version="1">MMIIDSPSTNAYFNIASEEYLLYKYPKEDIFLLYVNAPSIIVGKFQNTLSEINLDYVREQHIKVVRRMSGGGTVYHDTGNLNFSFHTLLGKNDFMDFSQFTQPVIAILNKMNVPARLEGRNDLLVDGKKFSGNAKLAKNGKMIQHGTILLNSQMNVLVEAIKVNPLKFVDKAVKSNRARVTNLIEYLPENTTTEILKQLLIGEMLQNNTEASVYQFTKEDIAGIEKLVTEKYSTWDWNYGFSPNYNFKKAVKIPAGFIELHLDVDKGIMEKVKIFGDFFASRPIEELEKVLTGQRHDVDHIEKLLSSTDLTAYFGKVSVAEILELFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTH8</accession>
    <name>D7VTH8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S1/P1 Nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_14282</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996379.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14282"/>
    <dbReference type="EnsemblBacteria" id="EFK57079">
        <property type="protein sequence ID" value="EFK57079"/>
        <property type="gene ID" value="HMPREF0766_14282"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z82C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044365_1_0_10"/>
    <dbReference type="OrthoDB" id="1079090at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="PTHR33146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="SSF48537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107574" evidence="6">
        <location>
            <begin position="23"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="262" mass="30369" checksum="226AACED9AB326E4" modified="2010-10-05" version="1">MKKIIKLLLLLAFFAQTSSVWGWGMTGHRVVTEIAERHLTNKAKKNIAKLIGKQHLAYWANWPDFVKSDHAFDETSPFHYINTEGNLTKEQFATALQQSPDNNIYKQLIRLSADLKAKDKGLTEMQQNLYFLIHLMGDAHQPMHVGRPADLGGNKIEVMWFGKPDNIHRVWDSNLVDYEKYSYTEYANVLDIHTRQENQRLTDGDFASWLYDTHIVANKIYKDVEQNSNLSYRYIYDNKYVVEDALLKGGLRLAKVLNEIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTK5</accession>
    <name>D7VTK5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_14309</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996415.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14309"/>
    <dbReference type="EnsemblBacteria" id="EFK57106">
        <property type="protein sequence ID" value="EFK57106"/>
        <property type="gene ID" value="HMPREF0766_14309"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031TV8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142057_0_0_10"/>
    <dbReference type="OrthoDB" id="1753156at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016944">
        <property type="entry name" value="UCP030066"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030066">
        <property type="entry name" value="UCP030066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK57106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="128" mass="14340" checksum="AEC8537ABCDC52A2" modified="2010-10-05" version="1">MKKNKIIFWIATTILILWEGVMPLGTLLFAPQYVNAGTKPLGYPDYFAYTLIICKVLGVIAISLPSVPVKIKEWAYAGLTFNLIFAFISHAYVDQVIAYMIMPLAVLAILILSYCYNPRIVHRKAVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTY0</accession>
    <name>D7VTY0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="9">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">murD</name>
        <name evidence="11" type="ORF">HMPREF0766_14450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MurCDEF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="9"/>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002297.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14450"/>
    <dbReference type="EnsemblBacteria" id="EFK55759">
        <property type="protein sequence ID" value="EFK55759"/>
        <property type="gene ID" value="HMPREF0766_14450"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032540_0_0_10"/>
    <dbReference type="OrthoDB" id="1093223at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="118"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="120"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK55759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="457" mass="50914" checksum="68E246AC9DA027A2" modified="2010-10-05" version="1">MTNIAQTYYPQSGKLIVLGAGESGVGAAILALQKGFEVLVSDKGVIAEKYQQQLEDAGITYESGHHSEELILNADLVVKSPGIPETAPLVVALKQKGIPVIGEIEFAAQYTNARLYCITGSNGKSTTTMLTYYILQKAGVNVGLAGNIGRSFALQVAQEKFDVYVLEISSFMLDDMYQFRADVAVILNITPDHLDRYDHKMENYVDSKFRMIRNQTANDYFIYCLDDEETVKGLERHHTEAAIWPMTQEQVINPGAYLDQEKNIIINTPKGEQFIMNTEDLSLQGKHNVYNNMAAGLVAKVQELRNRSMQESMSSYVNIPHRLEHVACIGGVNYINDSKATNVNSVWYALESFSPQIVLIMGGVDKGNDYEMLRDLVRSKVRAIICIGKDNTRIHESFEEDTDVIVNSSSMKDAVEIASHIAQKGDTVLLSPACASFDWFKNYEERGDKFKEAVMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGJ2</accession>
    <name>D7VGJ2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10111"/>
    <dbReference type="EnsemblBacteria" id="EFK59194">
        <property type="protein sequence ID" value="EFK59194"/>
        <property type="gene ID" value="HMPREF0766_10111"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072801_0_0_10"/>
    <dbReference type="OrthoDB" id="1828423at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107082" evidence="1">
        <location>
            <begin position="21"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="330" mass="38007" checksum="4D97539943286716" modified="2010-10-05" version="1">MRGLLLLFFAKVIFSNITFAQTYSQLNKSDTVTISSAIFQKERKIIITKSKEIKNGNTNNNCILYLDANFKNLNGIFLQSANNLIANNEIPPSYLIGVIHQDRNTELLEKDKLLRFISEEVIPWLEKEYNISKRITIAGHSFGAYFATYAFLKNNSLFNSCIALSPAYWPNKEDVLKLMDQEVKSNSVGGDFYLLVGDKRWDEISLRDYVFKAFEILNHTKAVRFKFNDLDGFSHNATTTVGFGLGLGFVYDEWEWGNILEEQEDRLKSFPDFWGHLEVKADALFHLKRVSEAKTVYKEALKVVPKDEDLSKKKKGQILKRIKSKIKNCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGP3</accession>
    <name>D7VGP3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996766.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10162"/>
    <dbReference type="EnsemblBacteria" id="EFK59245">
        <property type="protein sequence ID" value="EFK59245"/>
        <property type="gene ID" value="HMPREF0766_10162"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052345_5_1_10"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="299" mass="34064" checksum="DF890872153E7868" modified="2010-10-05" version="1">MEIKKYIIIDSKPILFPVEFTHADIAYQGAKIESAGIFTIFEGHDKRLRVKCMGKSNSLSVKSHPERDEFLIATYLGLMMAKQNNNIMPEISAYINSETDCLQKIADSMSLIYNETIAIKNNCILLPKAIGEGYMSIVELSNGLALFRANVRFKNQVKLSRNVIPSNTHLYLHFNLSESSCMIKKENGKMVDLGTGSKEMMFYSSSGKGIEMELPYDKWAKWITIIIHRSWLTIKQLNYSTHIGGNLIQAFLQNRVLQGMINLTTEEISLAYSLMEEKEPDSYMRLETKGKVLKLISYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH95</accession>
    <name>D7VH95_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4-hydroxyphenylpyruvate dioxygenase</fullName>
            <ecNumber evidence="7">1.13.11.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hppD</name>
        <name evidence="7" type="ORF">HMPREF0766_10364</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4HPPD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.27" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997254.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10364"/>
    <dbReference type="EnsemblBacteria" id="EFK59447">
        <property type="protein sequence ID" value="EFK59447"/>
        <property type="gene ID" value="HMPREF0766_10364"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034004_1_1_10"/>
    <dbReference type="OrthoDB" id="402639at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid family metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="PTHR11959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="177"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="375" mass="42562" checksum="3E43C061CE435257" modified="2010-10-05" version="1">MAQTFAEKIALAQDFLPINGTDYIEFYVGNAKQAAHYYKTAFGFQSEAYAGPETGVRDRASYVLKQNKIRLVLTTALRSEHPIAEHVKKHGDGVKILALWVDDATKSFEETVKRGAKPYQEPQVTKDQHGEVCTSGIYTYGETIHMFIERKNYKGTFMPGYEVWQSDYQPEETGLLYIDHCVGNVGWNKMNETVEWYQHVMGFVNVLSFDDKQINTEYSALMSKVMSNGNGYVKFPINEPAEGKKKSQIEEYLEYYEGEGVQHAALSTKDIVGTVKALKARGVEFLGAPPEAYYDMLPDRVGVIDEEIKVIQELGILVDRDDEGYLLQIFTKPVEDRPTLFYEIIQRKGAQSFGAGNFKALFEAIEREQEKRGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHC9</accession>
    <name>D7VHC9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997333.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10398"/>
    <dbReference type="EnsemblBacteria" id="EFK59481">
        <property type="protein sequence ID" value="EFK59481"/>
        <property type="gene ID" value="HMPREF0766_10398"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2920437_0_0_10"/>
    <dbReference type="OrthoDB" id="2195587at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="61" mass="7188" checksum="C643140C8EB83461" modified="2010-10-05" version="1">MVENFTKIKEDTYTTEDKDLTNYQDDVFEIKLKSNLQNLSKNPNRKTIESILAYSKSLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHG7</accession>
    <name>D7VHG7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">rpsD</name>
        <name evidence="11" type="ORF">HMPREF0766_10436</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997446.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10436"/>
    <dbReference type="EnsemblBacteria" id="EFK59519">
        <property type="protein sequence ID" value="EFK59519"/>
        <property type="gene ID" value="HMPREF0766_10436"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092403_0_2_10"/>
    <dbReference type="OrthoDB" id="1211060at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="10">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="9">
        <location>
            <begin position="93"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK59519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="202" mass="22878" checksum="531294D94086AA75" modified="2010-10-05" version="1">MARYTGPKSKIARKFREPIFGPDKALEKKNYPPGQHGPSKRRGKQSEYAIQLLEKQKAKYTYGVLERQFSNLFVKAAAKQGITGENFLKLLEARLDNTVYRLGIAPTRAAARQLVSHKHITVNGGVVNIPSYSLRPGDVIAVRERSQALEAVTTSVEGRKINKFAWLEWNANEFKGTFLSYPERTDIPENIKENLIVELYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHJ6</accession>
    <name>D7VHJ6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997504.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10465"/>
    <dbReference type="EnsemblBacteria" id="EFK59548">
        <property type="protein sequence ID" value="EFK59548"/>
        <property type="gene ID" value="HMPREF0766_10465"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4289">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028269_2_0_10"/>
    <dbReference type="OrthoDB" id="205789at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016624">
        <property type="entry name" value="UCP014753"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339">
        <property type="entry name" value="PTHR35339"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10022">
        <property type="entry name" value="DUF2264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014753">
        <property type="entry name" value="UCP014753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="420" mass="47762" checksum="96A98C6BCE314515" modified="2010-10-05" version="1">MKRRSLLQLLGSIGVGAMIPTVSAKADRSALSIAQKGPNDREYWISLLDKMAAPILDNISRQQLRKNMPMEVSPIFDSRDPGVGYLEAFGRLMSGLAPWLALPADNSSEGQLREKRKKQALLGIQYGMDPNSPDYFTWNTKSSQPLVDAAYLVQSFMRAPKALWEPLPAGTKANVIKELKGLRRIKPNESNWLLFAAMTETFLYKIGEECVREKIDYAIHKFDQDWYVGDGWYSDGASFSFDHYNGYVIHSMLVDVLRENIPADKKYQTLYDRAYKRMQRYAHHLDRMISPDGYFVVVGRSSTYRNAAFQPLAQLILEQKLPEDLTYGQLRASLTAVKRHVFVEGTFSAKGWLTMGLVGDRQSNLADYYTNAGSMYMASLSFLPLGLPADHEFWTTPAQQWTSQKAWKGEPFPKDYHVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHK8</accession>
    <name>D7VHK8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997529.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10477"/>
    <dbReference type="EnsemblBacteria" id="EFK59560">
        <property type="protein sequence ID" value="EFK59560"/>
        <property type="gene ID" value="HMPREF0766_10477"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137756_1_0_10"/>
    <dbReference type="OrthoDB" id="1798985at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="168" mass="20004" checksum="C4A8FBF62A33B38F" modified="2010-10-05" version="1">MNKITVFKLEMDMEEELDFVLLGISSPLRDYRLCHFINKTTGLQFVYGKESNIDHKGNMKEGGKEEYEYHIIQEKSKGKKPALKHHFAIYRYCDVDYEYEYYLINNRSQEGGLLIPEIANFDFFLVIKNFIHEEDLRLLIQNLNRINDVIMVKEIMPKILKSKENLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHP3</accession>
    <name>D7VHP3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997595.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10512"/>
    <dbReference type="EnsemblBacteria" id="EFK59595">
        <property type="protein sequence ID" value="EFK59595"/>
        <property type="gene ID" value="HMPREF0766_10512"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1255303_0_0_10"/>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="220" mass="25457" checksum="7266B8C2D026FAB4" modified="2010-10-05" version="1">MSNIGYNIKKLRNVKGLSQQAFAELFNLTRGNISSYEEMRAEPKIDIALKIANYFSIPLSNLIDKKLSVNEILNFNDYFEANTSIAPPKNLAGIPFLSRERVFLAKELHHNLESIPKIFFPLYGQENYLAVENSHFIPKHIEANNEENNILFFGMLQVDNLHTLTDKFGLYFSKEDFFIGKFQQNGTEISLVLNEWKSQPVSIEQLSDFWKLEGRYNQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHT7</accession>
    <name>D7VHT7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Beta-N-acetylhexosaminidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">N-acetyl-beta-glucosaminidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hex2</name>
        <name evidence="9" type="ORF">HMPREF0766_10556</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997717.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10556"/>
    <dbReference type="EnsemblBacteria" id="EFK59639">
        <property type="protein sequence ID" value="EFK59639"/>
        <property type="gene ID" value="HMPREF0766_10556"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007082_4_1_10"/>
    <dbReference type="OrthoDB" id="727559at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004866">
        <property type="entry name" value="CHB/HEX_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004867">
        <property type="entry name" value="CHB_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03174">
        <property type="entry name" value="CHB_HEX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SMART" id="SM01081">
        <property type="entry name" value="CHB_HEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107144" description="Beta-N-acetylhexosaminidase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="CHB_HEX" evidence="8">
        <location>
            <begin position="30"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="832" mass="93699" checksum="D6BBBEB033957271" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHV2</accession>
    <name>D7VHV2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997758.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10571"/>
    <dbReference type="EnsemblBacteria" id="EFK59654">
        <property type="protein sequence ID" value="EFK59654"/>
        <property type="gene ID" value="HMPREF0766_10571"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1288216_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="214" mass="25460" checksum="DBED323378DEC0B6" modified="2010-10-05" version="1">MKKPITIDNYKKLLFSKIICDYYAGPGDDKNVYDILMPIDDELTEIEESTIYFNQLLRMFEGIKKSQREDFVDYQVKKYGTLSEDWMFEVYNFLDEYENDINAIRPKMANEFKGVIDQKLRNKKKLLSNLKWASSETDFVVLTKALLTNNSIERTDGKKLYQKELDLVFEQFLNVEIKYKKDLLTSAKRMKIESNNFITKLREAWQTYINSKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI10</accession>
    <name>D7VI10_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-54 interaction domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">zraR</name>
        <name evidence="8" type="ORF">HMPREF0766_10629</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997890.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10629"/>
    <dbReference type="EnsemblBacteria" id="EFK59712">
        <property type="protein sequence ID" value="EFK59712"/>
        <property type="gene ID" value="HMPREF0766_10629"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_10"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="146"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="450" mass="50723" checksum="6571A3A44A6F4F24" modified="2010-10-05" version="1">MKKSTILVVDDDQDLLTAVRLLLKPQVGEVIIEHNPEKILSILAKKSVDAVLLDMNFKSTINTGNEGLYWLSRIREEYPVLPVVMITAYGAVDLAVKSLKNGASDFIVKPWQNETLLKSLEEALSVNKAKKADAKGILNSYTSTQLLGESEIMQDLYYKISKISPTDANILILGENGTGKDVIAREIHNQSLRYQKNFIKVDVGALTDTLFESELFGHKKGAFTDAREDRKGRIELAHEGTLFLDEIGNISLQQQAKLLTVLQNRQVTPLGSNHAADVDIRLLCATNIPIRELANESQFRKDLIYRINTVEVQVPPLRERGEDIMLLARHFLTIYAKKYNKSIADFSDESVYKLNGYHFPGNVRELQYSIERAVIMSETDRVEGKDLLFSPLENSVQPVVSGSSEQNLEVLERNTIKKVIEKYNGNISKAARELGLTRSALYRRLEKYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI12</accession>
    <name>D7VI12_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997894.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10631"/>
    <dbReference type="EnsemblBacteria" id="EFK59714">
        <property type="protein sequence ID" value="EFK59714"/>
        <property type="gene ID" value="HMPREF0766_10631"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_1_10"/>
    <dbReference type="OrthoDB" id="1497607at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="167" mass="18844" checksum="998CC138F8F3380D" modified="2010-10-05" version="1">MIKKPEEELIFEKFDQDDFELYYSLVRDEKVMAMITERAIPLSEAKADYEKILGINGLHSSFGYFKVKTAKAREFVGLAKLEVVAEDSKEAELGYILLPSHWGKGFGNQMASEMLMIARKESQISKVTAIIDPNNIPSRKILVNNGFVSEGFRDFDGLPGEILSLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI30</accession>
    <name>D7VI30_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997928.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10649"/>
    <dbReference type="EnsemblBacteria" id="EFK59732">
        <property type="protein sequence ID" value="EFK59732"/>
        <property type="gene ID" value="HMPREF0766_10649"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025443_6_0_10"/>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="177"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="425" mass="48771" checksum="99F1E9427817D167" modified="2010-10-05" version="1">MLIINAVILFILDFYIFFALRATKIKLVHKKWFGYAWWIYSILLLTGVFIGMKYNIPLTYRSVILVAFFLTATCKFFFFLVILIDDIRRGGVWISRLLRPIRKKEQLEDRIKEIEKPLPEEPKKGISRSEFLMKSGIVIASLPILPLGWGIVSGAYDYRIRRKKLYLPNLPASFHGMRIAQISDVHSGSFYNKKAVTGGIDMLLGEKPDAIFFTGDLVNNVASEMRDYQDIFTRVKADLGVFSTLGNHDYGDYYYGKEDSPAKRKNLQDVIDTHKVMGWDLLMDENRTLKVGNEEIAIVGVQNWGTGRFPKKGDLKKALMGTEEQPVKLLLSHDPSHWRAEVLDTDVDVMFAGHTHGMQFGVRTENFQWSPVKYIYKEWAGLYREKQNKQLYVNVGYGFLGYPGRVGILPEITIFELVKGTKPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI93</accession>
    <name>D7VI93_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycerol-3-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.39</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tagD</name>
        <name evidence="2" type="ORF">HMPREF0766_10712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.39" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998055.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10712"/>
    <dbReference type="EnsemblBacteria" id="EFK59795">
        <property type="protein sequence ID" value="EFK59795"/>
        <property type="gene ID" value="HMPREF0766_10712"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0615">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034585_2_3_10"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047348">
        <property type="term" value="F:glycerol-3-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="139" mass="16099" checksum="DF2BC6AF1A9BAC06" modified="2010-10-05" version="1">MKIGITFGVFDLLHAGHIMMLEEAKRNCDYLIVGLNTDPSEVFPEKNKPTQTIVERYIQLEGCRYVDEIVPYTSEQDLADIIQGMPIDIRIIGEEYRDKDFTGRQYCVDKGIEIYYNKRTHRFSSSGLRKVVAEKESDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIM4</accession>
    <name>D7VIM4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998312.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10843"/>
    <dbReference type="EnsemblBacteria" id="EFK59926">
        <property type="protein sequence ID" value="EFK59926"/>
        <property type="gene ID" value="HMPREF0766_10843"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160726_0_0_10"/>
    <dbReference type="OrthoDB" id="1937725at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="128" mass="15029" checksum="B949974EF5787BC8" modified="2010-10-05" version="1">MKLAFYWKDFLSLFFPECCFGCGAGLLYQEKFLCTTCLYHLPLTCFHLDNNNEPTRQLRGKCDFQNATAMLFLSKGTLVERILYQLKYNGHPEIGYFLGMKYGEVLRRTREYADVDLVVPVPLHRKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ40</accession>
    <name>D7VJ40_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11009"/>
    <dbReference type="EnsemblBacteria" id="EFK59175">
        <property type="protein sequence ID" value="EFK59175"/>
        <property type="gene ID" value="HMPREF0766_11009"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50337Z0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149369_1_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039437">
        <property type="entry name" value="Put_lumazine-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12893">
        <property type="entry name" value="Lumazine_bd_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107288" evidence="1">
        <location>
            <begin position="31"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="150" mass="17076" checksum="5F5DD24358CA6035" modified="2010-10-05" version="1">MTTKNINHMKTIIKTIATALLLITSFSSFANENPDPLKNMNSMAIVRTFLEASALGQATLNEELLAKDFQYYNASSPDLTYNKKQYSEFLKSTKGLKYNCKTSYQILDERGSHCVAKVTMKFENFTRVDYITLNRSTESWKVSKVVSTFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ65</accession>
    <name>D7VJ65_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_11034</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000388.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11034"/>
    <dbReference type="EnsemblBacteria" id="EFK58918">
        <property type="protein sequence ID" value="EFK58918"/>
        <property type="gene ID" value="HMPREF0766_11034"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050164_2_1_10"/>
    <dbReference type="OrthoDB" id="1712258at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="134" mass="14887" checksum="407C1E26A5A27B9C" modified="2010-10-05" version="1">MTLEERINLAETRVCTTVFPFLTNHHDTLFGGKAMAIMDEVSFMAATRFCRKTLVTVSTDRIDFTKAIPSGSIIEAIARVDSIGRTSLKVKVEIYLEDMYKEGRELAISGLFTFVALDENKKPVPVLQGIAIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJA2</accession>
    <name>D7VJA2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SUFU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11071"/>
    <dbReference type="EnsemblBacteria" id="EFK58955">
        <property type="protein sequence ID" value="EFK58955"/>
        <property type="gene ID" value="HMPREF0766_11071"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082045_0_0_10"/>
    <dbReference type="OrthoDB" id="1944952at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020941">
        <property type="entry name" value="SUFU-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05076">
        <property type="entry name" value="SUFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUFU" evidence="1">
        <location>
            <begin position="58"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="236" mass="28211" checksum="F9CCEB7DBEF4603B" modified="2010-10-05" version="1">MHDRAYGDKKNMDKELIRKIQDRKHYYEHVEALQKHLDEYFESEDMTVFHEMLSLDFHLDVYFIQPKDKEFNLLITSGMSLLEMNVPETIQDRADYTFAELMLLIPKDIKFNKTYPSDDKNDWIIGMMKDMARFPHHQDTFLTEGHTLQAWNDIADPYDKHTLFTGCILLPSATFGEDFMQITCEDRIINFYSLFPLYKNEMEYKIQHGYSRFFDLLIENDVAEVFDEKRENLLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJC5</accession>
    <name>D7VJC5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000569.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11094"/>
    <dbReference type="EnsemblBacteria" id="EFK58978">
        <property type="protein sequence ID" value="EFK58978"/>
        <property type="gene ID" value="HMPREF0766_11094"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061971_1_0_10"/>
    <dbReference type="OrthoDB" id="864499at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016645">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008471">
        <property type="entry name" value="MnmC-like_methylTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05430">
        <property type="entry name" value="Methyltransf_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_30" evidence="1">
        <location>
            <begin position="143"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="221" mass="24783" checksum="3B8E7A38AD9D9DB5" modified="2010-10-05" version="1">MDFVITGDGSKTLFNAEIGECYHSKHGALQESKHVFIQMGLDFYVKHTGLQKVSVLEIGFGTGLNFLQTAEYVSDSDIHVDYVGIEGYPLPLEVIKDTGYNAYVDPLIWHSFTDNYDKSFGSSLPVIEKMNLHIAHTLLMDFTSEKQFDIVYFDAFAAVHQPEMWSDEALGHIARYIKPGGVFVTYAITGNLKRSMKALGFKIEKAPGAPGKREMLRAIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJD9</accession>
    <name>D7VJD9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TrkA C-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000595.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11108"/>
    <dbReference type="EnsemblBacteria" id="EFK58992">
        <property type="protein sequence ID" value="EFK58992"/>
        <property type="gene ID" value="HMPREF0766_11108"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0490">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116143_0_0_10"/>
    <dbReference type="OrthoDB" id="941006at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026278">
        <property type="entry name" value="K(+)/H(+)_antiporter_KhtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005028">
        <property type="entry name" value="KhtT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK C-terminal" evidence="3">
        <location>
            <begin position="76"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="159" mass="17440" checksum="1B87B686A4F1ED70" modified="2010-10-05" version="1">MSIVRESDLIGIGKKYQIETDAGDSMVVVIHDDGRRELYRYDAEENESRCVMTLTDEESRQVAGIIGGLSYKPKALETIEVALDDLIIEWYKVVGTDVSCNKTIGELAVRKNTGASIIAGIRDTDTVINPGPDYEISPGTTLVIAGKRSNIKALKEILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJE3</accession>
    <name>D7VJE3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GH3 auxin-responsive promoter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000599.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11112"/>
    <dbReference type="EnsemblBacteria" id="EFK58996">
        <property type="protein sequence ID" value="EFK58996"/>
        <property type="gene ID" value="HMPREF0766_11112"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016249_4_0_10"/>
    <dbReference type="OrthoDB" id="566369at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004993">
        <property type="entry name" value="GH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31901">
        <property type="entry name" value="PTHR31901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03321">
        <property type="entry name" value="GH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="504" mass="58369" checksum="A3FF52D3FC33D184" modified="2010-10-05" version="1">MALLNSLFTWFLKKRMHQIDLFIKYPHEVQEEWFQSLISTAEATEWGKKYDYKSILTPEEFKERVPIQDYDSIKGYVDRMIKGEQNILWPSDIKWFAKSSGTTADKSKFIPVSEEALEECHYQGGKDMLSIYCHNRPENKLFTGKSVVLGGSSQINSFNSDSYYGDLSSILIRNLPFWAEFKRTPNTEVTLNPNFEEKIENIANITIKENVTSLAGVPTWNVVMAKRILEITGKSNLLEVWPNLEFYSHGGVSFKPYREQFKKLIPSENMYYLENYNASEGYFALQDRSDSDDLLLMLDYGVYYEFLPIENLHDEHPKTLSLDQVEIGKNYALIISTNAGLWRYMIGDTIKFTDLSPYRIQVSGRTKQYINTFGEEVIVDNAEMAVNKACERTHAIVKDYTAGPVYFKDGEAGAHEWIIEFEQQPDNFEHFCQILDDTLKSVNSDYEAKRFKNMALSFPIIHNAPQNTFFGWMKSRDKLGGQNKVPRLSNNREYLEPILKLMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJK3</accession>
    <name>D7VJK3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="5 6">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">nadE</name>
        <name evidence="9" type="ORF">HMPREF0766_11172</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="5 6"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000702.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11172"/>
    <dbReference type="EnsemblBacteria" id="EFK59056">
        <property type="protein sequence ID" value="EFK59056"/>
        <property type="gene ID" value="HMPREF0766_11172"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022313_2_0_10"/>
    <dbReference type="OrthoDB" id="1152435at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for glutaminase activity" evidence="5">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" description="For glutaminase activity" evidence="5">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutaminase activity" evidence="5">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="295"/>
            <end position="302"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="546" mass="59924" checksum="DEB495713C12E7A4" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJK8</accession>
    <name>D7VJK8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_11177</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000712.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11177"/>
    <dbReference type="EnsemblBacteria" id="EFK59061">
        <property type="protein sequence ID" value="EFK59061"/>
        <property type="gene ID" value="HMPREF0766_11177"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_0_2_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107022" evidence="5">
        <location>
            <begin position="26"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="120"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="426"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1077" mass="118038" checksum="9641178FEBB12915" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJR5</accession>
    <name>D7VJR5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000855.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11234"/>
    <dbReference type="EnsemblBacteria" id="EFK59118">
        <property type="protein sequence ID" value="EFK59118"/>
        <property type="gene ID" value="HMPREF0766_11234"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033Q10">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_535170_0_0_10"/>
    <dbReference type="OrthoDB" id="754276at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107298" evidence="1">
        <location>
            <begin position="23"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="485" mass="54689" checksum="11A5F513C1B3C05C" modified="2010-10-05" version="1">MKRRAKLYLGLFLAWHVLFSCSKSVSVPEGRESYRVDFVLSGFTASVSSLDNGLKLVANSGNNVISGEQPLYFWSFNNGTLRPDLALDEDGVQWTVTPNNVDFVAGKAYGEYNAGRAASFRGVTQIEIAIPLKDVKSLNHLAFNVSGSDTGPKALDLLYSVDNGLTFVGLLSDYDMSSIKGTAWGDITADLTKLQRTEEIQKIIFRLVLKRGNNGQFNEKTGTIRIDNMRLSGSYDGKIVTVNPVLRHLYYHIFNSQDRKLVTEGRIELERNSLEMNLPLTLASGSYDVSFVLSQAVKTLTLPRTIKTADDYYLYNTFDNSDNQVFGERIMSLKVGEDLKIPLVLQRYYSQVKFEFTDKADLSEVGKIEIVQEHELPYYVPFSEARFPDLSDGSAIIFYPEFGKTEPVLQFNQFLGYLPIARDIGYALKVYNKENKIIREFSVSSTLKHNMKLTFKGMLLEGFSSNANFAIQLNEEWGKDVEQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJS2</accession>
    <name>D7VJS2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000873.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11241"/>
    <dbReference type="EnsemblBacteria" id="EFK59125">
        <property type="protein sequence ID" value="EFK59125"/>
        <property type="gene ID" value="HMPREF0766_11241"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZBVN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132521_0_0_10"/>
    <dbReference type="OrthoDB" id="1905527at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009474">
        <property type="entry name" value="YphP/YqiW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40052">
        <property type="entry name" value="PTHR40052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06491">
        <property type="entry name" value="Disulph_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04191">
        <property type="entry name" value="YphP_YqiW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="136" mass="14920" checksum="4ADD168836D1C5EA" modified="2010-10-05" version="1">MYPEYLVEPMRKELTDAGFQELKTIAEVDSAIPSEGTVFVVVNSVCGCAAANARPAAKAAVKNEKHPDKLVTVFAGMEKDAVDKAREYMLPYPPSSPAMALFKDGKLVHMIERHMIEGRPAQMIADNLVAAFDEYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJU0</accession>
    <name>D7VJU0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MORN repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998622.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11259"/>
    <dbReference type="EnsemblBacteria" id="EFK58542">
        <property type="protein sequence ID" value="EFK58542"/>
        <property type="gene ID" value="HMPREF0766_11259"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2849">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1314732_0_0_10"/>
    <dbReference type="OrthoDB" id="1997695at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107028" evidence="1">
        <location>
            <begin position="23"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="209" mass="23799" checksum="1D8D99866C46ACE2" modified="2010-10-05" version="1">MKISIYLTLLSLSLAFSSGAQKRQEVQYNRFTINGEDGSKQTFFAEDKRINSKSDRLYSWYASNKITLTEGGFSGKLLNGEYTRYYPNKNLAEKGIFKFGLRNGLWRSWSSEGLLTKESNWIEGIETGAFVQYNSDGKQEKKGELKNGKLHGAIQLFSGSDSTSVQYYNEGKSISEEEYINSNLFRKSGSYLGRTFGKLFNKNKEPKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJU9</accession>
    <name>D7VJU9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11268"/>
    <dbReference type="EnsemblBacteria" id="EFK58551">
        <property type="protein sequence ID" value="EFK58551"/>
        <property type="gene ID" value="HMPREF0766_11268"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2939441_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="60" mass="7164" checksum="35A3C46F45EEEC9E" modified="2010-10-05" version="1">MKVGFRKIEILSVKAPVYKVKTIFLLPNQYVLIEFYTGIQNTQKKTEFDITNQFNPLYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJW9</accession>
    <name>D7VJW9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11288"/>
    <dbReference type="EnsemblBacteria" id="EFK58571">
        <property type="protein sequence ID" value="EFK58571"/>
        <property type="gene ID" value="HMPREF0766_11288"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044440_1_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005672194" evidence="2">
        <location>
            <begin position="24"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="281"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="312" mass="34663" checksum="8DDA4E67C325F86F" modified="2010-10-05" version="1">MKNKIIKVTGIALSMLLTHIGFAQQDNRVQIGFDGPAYGVNLLADFGTGISGGWARGYRISNNDDSESFIQLGTMGNYDITGKSFQAYSYIGKNYDRPFMIFQPDGNIGIGITTVENNEGWEKALQVHGTDHAKLLVTTNAVRTGMWSHNSGYYGAAAGGMVGTHTNHPFSIITNGVSKVTILSNGYTGIGTTTPTERLSVNGNIRAREIKVETNNWPDYVFEEDYKLKSLTEVEIFIKANKHLPDVPSAKEIEEEGLSVGEMNKLMMKKIEELTLHLIEKDKEIRDLKGIKQEIVALQEEIQQLKENLMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJZ8</accession>
    <name>D7VJZ8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nagZ</name>
        <name evidence="7" type="ORF">HMPREF0766_11317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11317"/>
    <dbReference type="EnsemblBacteria" id="EFK58600">
        <property type="protein sequence ID" value="EFK58600"/>
        <property type="gene ID" value="HMPREF0766_11317"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007082_5_1_10"/>
    <dbReference type="OrthoDB" id="727559at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20b" evidence="6">
        <location>
            <begin position="8"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="5">
        <location>
            <begin position="135"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="510" mass="57816" checksum="F9A5F36DA11B7E9E" modified="2010-10-05" version="1">MSLKAKAIDVIPRPASVLEKKGEYLIKNNIGIYTNGKVDNEVTFIAEILKDEQGLKSSKVTSPKQAGIHLLINITLRQELGAEGYHLEVDRSGIRIEAPTSTGVFYGIQTLRQLIKKESGIAKLGCIKISDKPRFSWRSYMLDEGRAYKGKDVVKTLLDEMAALKMNVFHWHLTEDQGWRLAIEKYPNLTKIGARRDSTQIGGWNSDKYDRKPLEGYYTRADVKEIVAYAKARHINIVPEIEMPGHASAAIASYPWLGVTKLPIKVPASFGVKYDVFDVTDPKVIGFLQDVLSEVITMFPSDVIHIGGDEVKYNQWNDSPEVQAYMKKHALISPADLQISFTNGISNFLEKNNKRMMGWNDIMGAKLHDYNQDAAPVTGTLSKSAIIQFWKGNVDLMKEAARNGYAIVNSYHEATYLDYSNISLEKAYSFDPVPEGLDKQYHAKILGLGCQMWGEWILDVKDMYKQTFPRIAAYAEVGWTDVENKDYVGFQHALPYFYNRWNKKQIDFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK35</accession>
    <name>D7VK35_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HopJ type III effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hopJ</name>
        <name evidence="1" type="ORF">HMPREF0766_11354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998889.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK58637">
        <property type="protein sequence ID" value="EFK58637"/>
        <property type="gene ID" value="HMPREF0766_11354"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032RP0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121622_1_1_10"/>
    <dbReference type="OrthoDB" id="1690330at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014984">
        <property type="entry name" value="HopJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038604">
        <property type="entry name" value="HopJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08888">
        <property type="entry name" value="HopJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="109" mass="12272" checksum="5A626CF3BF12BF0D" modified="2010-10-05" version="1">MEELFTQLSARQATFADVLAYIAVHYDYTPSAFQNGLQHNAATENQGSAKVFAFALDQELTKDQTLALFAEHYTAVLQTPEGTDHQNIRQFMINGWHGIHFEGQALKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKA9</accession>
    <name>D7VKA9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dapL</name>
        <name evidence="3" type="ORF">HMPREF0766_11428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999082.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11428"/>
    <dbReference type="EnsemblBacteria" id="EFK58711">
        <property type="protein sequence ID" value="EFK58711"/>
        <property type="gene ID" value="HMPREF0766_11428"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_5_10"/>
    <dbReference type="OrthoDB" id="417859at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="33"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="384" mass="43154" checksum="F48A13AB3A080B1E" modified="2010-10-05" version="1">MQINVAKRLQQTEEYYFSKKLREIDELNKSGARVINLGIGSPDLPPHPEVIQTLHEKASLPNTHGYQNYKGSPVLRKAIADWYERYYRVYLNPEKEILPLIGSKEGIVHICMTYLQDGDEVLIPNPGYPAYAAAVRLSGATAVPYTMTAENDWLPNLKELEQTDLSKVKIMWINYPHMPTGSKATASFFEAVIAFGKKHNILICHDNPYSFILNDHPQSILETEGAKDVAIELNSLSKSSNMAGWRIGMLCAAEERINEILRFKSNMDSGMFLPLQLAAAKALSLDSTWYTELNAAYQKRKDKALELLNLLNCSYREDQVGLFIWAKVPEKYANGYELSDEVLNKARVFITPGGIFGHAGNGYIRVSLCATEAVFEEAIARIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKC8</accession>
    <name>D7VKC8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">cas2</name>
        <name evidence="10" type="ORF">HMPREF0766_11447</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999140.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11447"/>
    <dbReference type="EnsemblBacteria" id="EFK58730">
        <property type="protein sequence ID" value="EFK58730"/>
        <property type="gene ID" value="HMPREF0766_11447"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150500_0_0_10"/>
    <dbReference type="OrthoDB" id="1841250at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK58730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="110" mass="13164" checksum="AF6D6911C84CD3AA" modified="2010-10-05" version="1">MNRLNQYRVLWILVFFDLPTETKKDRAVHARFRKEIMQDGFTMFQFSIYLRHCNSRENADVHVKRVKRLLPEKGHIGILTITDKQFGDIELFIGKDKSKRPDTPQQLELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKF1</accession>
    <name>D7VKF1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphodiester phosphodiesterase family protein</fullName>
            <ecNumber evidence="3">3.1.4.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glpQ3</name>
        <name evidence="3" type="ORF">HMPREF0766_11470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.46" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999200.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11470"/>
    <dbReference type="EnsemblBacteria" id="EFK58753">
        <property type="protein sequence ID" value="EFK58753"/>
        <property type="gene ID" value="HMPREF0766_11470"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_9_0_10"/>
    <dbReference type="OrthoDB" id="1542724at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106982" evidence="1">
        <location>
            <begin position="25"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="49"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="293" mass="33591" checksum="C93E438E98BC93BF" modified="2010-10-05" version="1">MNTYCKLFLTLFLFTCYTISNAFAQKLHTQNYKTVADMYKAFQYAPGKKIISGHRGTIEQGLPENSIPAFEAVLRHTPAIFEIDPRLTKDSIAVLLHDAELERVTNGKGKVSDYTWKDLKKLKLKDHAGNLTPYRINTLDEVIEWAKGKTILNLDKKDLPIEMTAGIIKKHNAYNWVWVTVHHVDQAKFYRDKNPDQYMSMHIKDQSALDKFKSSGLPYNRMIVYIGPEIKEANQQMYAFFHAKGVMCMISTAPTYDKLSSKEARAERYRAVFEDGASILESDLPIEVVQALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKJ0</accession>
    <name>D7VKJ0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999314.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11509"/>
    <dbReference type="EnsemblBacteria" id="EFK58792">
        <property type="protein sequence ID" value="EFK58792"/>
        <property type="gene ID" value="HMPREF0766_11509"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_87_1_10"/>
    <dbReference type="OrthoDB" id="1757088at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="169"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="265" mass="30897" checksum="32D923BABFEC1FEE" modified="2010-10-05" version="1">MQNDMKCGLLEQKQGELSDTISKHAYVWYEKDWKHDDYEHIHSRAQLLYVEEGYQYVHLEQKIYLLPQNHVMWIPSSISHRTTSAAQTVNLMTILFHEKQTEAFYKDIHVFAAPAILKEMLLYAQKWSQQMAPDQEEEAFLNALLISLPYFCQEADSLQIPIPSDTRLLPVCAYINMHFHEQVQIQQLSEIAHLSVRTLERIFKQETGITVQKYIQLIRVIKSIEWSDSGKYTLKQIAHMVGYKSAAAFSSSYLAIMKKRPGTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKN3</accession>
    <name>D7VKN3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">D-alanyl-D-alanine dipeptidase</fullName>
            <shortName evidence="3 4">D-Ala-D-Ala dipeptidase</shortName>
            <ecNumber evidence="3 4">3.4.13.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ddpX</name>
        <name evidence="5" type="ORF">HMPREF0766_11552</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>D-alanyl-D-alanine + H2O = 2 D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20661"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="EC" id="3.4.13.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase M15D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.22" evidence="3 4"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999402.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11552"/>
    <dbReference type="EnsemblBacteria" id="EFK58835">
        <property type="protein sequence ID" value="EFK58835"/>
        <property type="gene ID" value="HMPREF0766_11552"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060744_0_1_10"/>
    <dbReference type="OrthoDB" id="880710at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01924">
        <property type="entry name" value="A_A_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000755">
        <property type="entry name" value="A_A_dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01427">
        <property type="entry name" value="Peptidase_M15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026671">
        <property type="entry name" value="AA_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 4 5" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 4" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR026671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="233" mass="27191" checksum="E18DB1BC17E5C5F6" modified="2010-10-05" version="1">MFTDIKMKKIIILSLLLLGTLSFASIHPVQKLPEGFVYIHKLIPNIQYDIRYAGNHNFTGKKINSYNKEVAILSKPAARALKNVQRELNRKGLGLKIFDAYRPQTAVDNFKEWALMIEDTLAKQEFYPDIDKRDLFKSGYIAEKSGHSRGSTVDLTLIYIKSKIELDMGSPFDYFGTPSHHDYDDLTGSQKENRQILKTIMEKYGFKSYQKEWWHYTLKDEPYPNEYFNFPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKT2</accession>
    <name>D7VKT2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999488.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11601"/>
    <dbReference type="EnsemblBacteria" id="EFK58884">
        <property type="protein sequence ID" value="EFK58884"/>
        <property type="gene ID" value="HMPREF0766_11601"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084727_0_0_10"/>
    <dbReference type="OrthoDB" id="1589192at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="285" mass="31966" checksum="0CE6C2C41D6FA142" modified="2010-10-05" version="1">MIIIADGGSTKTNWCLLDDSNKKIYFNTEGYNPYFVDSEYIVNSLKKGLPLDLPFDKISEVNYYGAGVHNQEKAQIVVNAIQQVFPNSKVEVGHDLLAAARALLGTESGFAAILGTGTNSCIYDGEEITKNIDSGAYILGDEGSGSYIGKKLLIDYIRDLMPADVKKVFYETYKLLPDEIMDSVYTKPLANRFCASFSKFVYDNNVNIQYTRKIVEDSFEAFFSNLVSKYPDYQSYTFNCIGSVGYNFRNVLEEKAGQYGMKVGKILRSPIDDLVQFHMNRAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKT5</accession>
    <name>D7VKT5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999492.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11604"/>
    <dbReference type="EnsemblBacteria" id="EFK58887">
        <property type="protein sequence ID" value="EFK58887"/>
        <property type="gene ID" value="HMPREF0766_11604"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1309455_0_0_10"/>
    <dbReference type="OrthoDB" id="1473468at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="203" mass="23280" checksum="CF3FD3A22FD8695E" modified="2010-10-05" version="1">MLEYKNALIDELVEKLNLQPISIEPALVQSAQDIASFEDLKLFIERFTHMHTPASNLAEELEEEVDILVHKLKFIPTETRPKVLLLENIDPASPLQSALITESIRIAGGVPLEIQEYKDADILLIKQDEFLLYGQLPQFIQQEEWSSIPAIKNNKIYIIKKDDFANVPGKDYLLELEILAEIIQPKYFIFGHHGVDWINFDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKW4</accession>
    <name>D7VKW4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma factor regulatory protein, FecR/PupR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999574.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11633"/>
    <dbReference type="EnsemblBacteria" id="EFK58237">
        <property type="protein sequence ID" value="EFK58237"/>
        <property type="gene ID" value="HMPREF0766_11633"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050192_1_0_10"/>
    <dbReference type="OrthoDB" id="1381035at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032508">
        <property type="entry name" value="FecR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16344">
        <property type="entry name" value="DUF4974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="174"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4974" evidence="3">
        <location>
            <begin position="313"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="383" mass="43155" checksum="68FFBE25FB1FEC07" modified="2010-10-05" version="1">MYSPEDKEKYQQLASKWLDKTITEEELQVFNAWYESDPDGIIEISESFAQTEGQLAERMLKGINSRIHKTRVYSLWTRISVAASVLLLLGASFYVYRYSTTEKQHSRQVQSQDSIAPGKSGATLTLANGRKIRLSDAAVGELVTEYGTRISKTADGGLLYDEESAGKSSTAQNTLSTAKGEMYMMTLPDRTKVWLNSGSALTFSPTFNEQNSRSVTLTGEAYFEVAKDKRRPFVVTTAKQKVTVLGTHFNISSYADEKEVKTTLIEGAVKVHNLQSGTVLLLKPDQQAVVNGENLYMQQVDVNEIIAWKNGDFVFGTESFEASMRKIERWYDVEFVYKESDIKDIRLDGWIARSSRLSDVLHKIELAGNIKFEIKGRRILLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKY7</accession>
    <name>D7VKY7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Catalase</fullName>
            <ecNumber evidence="11">1.11.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cat2</name>
        <name evidence="11" type="ORF">HMPREF0766_11656</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="11"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999635.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11656"/>
    <dbReference type="EnsemblBacteria" id="EFK58260">
        <property type="protein sequence ID" value="EFK58260"/>
        <property type="gene ID" value="HMPREF0766_11656"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_2_0_10"/>
    <dbReference type="OrthoDB" id="1584770at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08156">
        <property type="entry name" value="catalase_clade_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040333">
        <property type="entry name" value="Catalase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="PTHR11465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="10">
        <location>
            <begin position="9"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK58260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="498" mass="56962" checksum="F772EEEC497BD48C" modified="2010-10-05" version="1">MEENKKKITTASGAPVVNYEDTMTAGPRGPVLLQDYFLHEKLAHFNRERIPERIVHAKGSGAYGTFTVTNDITQYTRAKFLNEVGKQTRLFIRFSTVGGEKGSADSERDPRGFAVKFYTEDGNYDLVGNNTPVFFVKDAKKFPDFIHTQKRDPYTNCKSPTMMWDFWSLNPESLHQVTILMSDRGTPYGYRHMHGFGSHTFSMINANNELVYVKYHFRTEQGIKNLTDAEAADMRREDPDYAQRDLVEAIDSGNFPKWKLYIQVMTVEQTKTFRWNPFDLTKVWSQKEYPLIEVGVMELNENPDNYFAHVEQAAFAPAHVVDGISFSPDKMLQGRILSYPDAQRYRLGGNYEQIPVNRCPFMVTNYQRDGLMTVNGNSGSDPNYYPNSFDGHYEDQSYKEPAIQLDSTIGDHYDRNAPGEDDHYTQPGDLYRLLDAEQKQHLINNIVGAMSGIEGPKKMEIINRQLCHWFRADINLGIGVAQGLGLDMAELSKHMPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL30</accession>
    <name>D7VL30_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase, C-terminal domain protein</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">acdA2</name>
        <name evidence="9" type="ORF">HMPREF0766_11699</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999741.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11699"/>
    <dbReference type="EnsemblBacteria" id="EFK58303">
        <property type="protein sequence ID" value="EFK58303"/>
        <property type="gene ID" value="HMPREF0766_11699"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_3_3_10"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="28"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="143"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="250"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK58303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="592" mass="64940" checksum="CF97AAD51E71EAF2" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL56</accession>
    <name>D7VL56_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999782.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11725"/>
    <dbReference type="EnsemblBacteria" id="EFK58329">
        <property type="protein sequence ID" value="EFK58329"/>
        <property type="gene ID" value="HMPREF0766_11725"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2425424_0_0_10"/>
    <dbReference type="OrthoDB" id="1930641at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="91" mass="10073" checksum="853344B3E749F650" modified="2010-10-05" version="1">MVISATPIFSSSVDKDHILQVVLQIEIENNAKAPSQAEDHQDSGSKYFSGTADITTFSCPETVVKNNEFHFWDEKHICAFHPSVPTPPPNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL93</accession>
    <name>D7VL93_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11762</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999898.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11762"/>
    <dbReference type="EnsemblBacteria" id="EFK58366">
        <property type="protein sequence ID" value="EFK58366"/>
        <property type="gene ID" value="HMPREF0766_11762"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_574785_0_0_10"/>
    <dbReference type="OrthoDB" id="1297581at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040683">
        <property type="entry name" value="CshA_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045474">
        <property type="entry name" value="GEVED"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18651">
        <property type="entry name" value="CshA_NR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20009">
        <property type="entry name" value="GEVED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107645" evidence="1">
        <location>
            <begin position="22"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="CshA_NR2" evidence="2">
        <location>
            <begin position="45"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="GEVED" evidence="3">
        <location>
            <begin position="382"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="475" mass="50451" checksum="844B3134455CE62B" modified="2010-10-05" version="1">MRKILLFILICSFFAQHNALGQCTLPAGKFATAAFATGGSSIYKNNVLWLTWGAQAATDTYGKHNQTLSNGSASYASINMGGGRYLCIQATISNLVGLINSYAPGNYSGDSMDDMYNIGGTGSNNKLVSGIRNTTDAASVSFTLTCKATIDGVPVRLNGMVLGDAESLAAGENFTATASGTWSIVDLKKNTSVTGAYEVRKDNLTGNKQKLSFLRGNDNNTGAVAFLTFNEQAFQGTDLSVSFDVTLKGGGLTAISLGLLPPAIDGGDAPESYGTPLHMIDALNVKYDNIPVNTVVNLNTTSYQVGGLEAPVSGFLGTTGPDADNKPLYSKDAMGDNNDGIAGVNEEDAWPAQYKSFSYKLYYNPNQTITVAIPYKAYRDGYIAGWIDFNQNGVFEASERAVATATASGTSVNLIWTVPANRVIRSTYVRLRYGYNLNELQLPTGSAVGGEVEDHKIFIQGSAITNPMLPNKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLB2</accession>
    <name>D7VLB2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999956.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11781"/>
    <dbReference type="EnsemblBacteria" id="EFK58385">
        <property type="protein sequence ID" value="EFK58385"/>
        <property type="gene ID" value="HMPREF0766_11781"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018718_1_0_10"/>
    <dbReference type="OrthoDB" id="893200at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025150">
        <property type="entry name" value="GH123_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045711">
        <property type="entry name" value="GH123_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13320">
        <property type="entry name" value="DUF4091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19543">
        <property type="entry name" value="DUF6067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6067" evidence="2">
        <location>
            <begin position="155"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4091" evidence="1">
        <location>
            <begin position="471"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="577" mass="65985" checksum="7FDDF6D2410BA40E" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLD8</accession>
    <name>D7VLD8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter, SSS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_11808</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000027.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11808"/>
    <dbReference type="EnsemblBacteria" id="EFK58411">
        <property type="protein sequence ID" value="EFK58411"/>
        <property type="gene ID" value="HMPREF0766_11808"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018808_11_4_10"/>
    <dbReference type="OrthoDB" id="231452at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="495" mass="55139" checksum="C8DFECC4D7B1D25F" modified="2010-10-05" version="1">MSPLILLTFLLVYFGLLLGVAYFTSRKSSDNSTFFVANRNSKWYMVAFGMIGTALSGVTFISVPGAVGHTNFSYFQFVLGNAVGFVMIAYVLLPLYYRMNLTSIYTYLEERFGHKSYKSGAMIFLISRTIGSAFRLYLVAIILQKFIFDSLQVPFAVTIAICLILIWMYTNKGGLKTIIITDTLQTFFLLLAVVLSIYFMADGLGISVVEAFEKVKNSSYSSIFVWEDLLGDKNHFLKNFIGGIFVTIAMTGLDQDLMQKNLSMSTIGEAQKNMLTFTSIFVVINLFFLAVGALLYIYAAENNIDVSALRTPDYLYPEIALNYLSLAPGIIFMMGLTAATFATTDSALTALTTSFCVDFLNFNKKANPNDPALVRQRNWVHVGFSVLMLVVILIFRILNDDSVVTAIFVAASYTYGPLLGLFALGILTRYRVNDNLVPLICVLSPVILFLINYFLIVPHTTYRIGYELIVYNGFLTALMLIITSPGKQHADTKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLF9</accession>
    <name>D7VLF9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11829"/>
    <dbReference type="EnsemblBacteria" id="EFK58432">
        <property type="protein sequence ID" value="EFK58432"/>
        <property type="gene ID" value="HMPREF0766_11829"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_198984_1_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="46" mass="5456" checksum="5CDC15D03FD2C9DB" modified="2010-10-05" version="1">MDSFNKKDSEKPVNSNIRLMRNINIIAITIFVLAILFKVIQHFFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLG7</accession>
    <name>D7VLG7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">ATP-dependent DNA helicase RecG</fullName>
            <ecNumber evidence="3 6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">recG</name>
        <name evidence="9" type="ORF">HMPREF0766_11837</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 6"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000111.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11837"/>
    <dbReference type="EnsemblBacteria" id="EFK58440">
        <property type="protein sequence ID" value="EFK58440"/>
        <property type="gene ID" value="HMPREF0766_11837"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005122_7_1_10"/>
    <dbReference type="OrthoDB" id="234717at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004609">
        <property type="entry name" value="ATP-dep_DNA_helicase_RecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045562">
        <property type="entry name" value="RecG_dom3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033454">
        <property type="entry name" value="RecG_wedge"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19833">
        <property type="entry name" value="RecG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17191">
        <property type="entry name" value="RecG_wedge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00643">
        <property type="entry name" value="recG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="286"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="467"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK58440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="701" mass="79763" checksum="D00B3DC871A7F9E3" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLZ9</accession>
    <name>D7VLZ9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Lon protease</fullName>
            <ecNumber evidence="5 6">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 13" type="primary">lon</name>
        <name evidence="13" type="ORF">HMPREF0766_11996</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 9">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6 9 10">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="5 6"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001156.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11996"/>
    <dbReference type="EnsemblBacteria" id="EFK58004">
        <property type="protein sequence ID" value="EFK58004"/>
        <property type="gene ID" value="HMPREF0766_11996"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004109_4_0_10"/>
    <dbReference type="OrthoDB" id="128102at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="12">
        <location>
            <begin position="43"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="11">
        <location>
            <begin position="624"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="711"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="754"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <begin position="388"/>
            <end position="395"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFK58004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="821" mass="91991" checksum="E3BB23151FD4A428" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM01</accession>
    <name>D7VM01_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001162.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11998"/>
    <dbReference type="EnsemblBacteria" id="EFK58006">
        <property type="protein sequence ID" value="EFK58006"/>
        <property type="gene ID" value="HMPREF0766_11998"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503348V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1229236_0_0_10"/>
    <dbReference type="OrthoDB" id="1200648at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107300" evidence="1">
        <location>
            <begin position="23"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="229" mass="25246" checksum="C5FFEBFDB4372E3E" modified="2010-10-05" version="1">MLMKTSLAFLLLLFCVQGAVRAQSGVDTLHYRKVYYFGGTGLAFPMGKTKDVLTPKFSGSMGLDISLKDSRFYVMPVLYTLSFGYKQQLLDNSSPYRINNGDATFYNLSLSGGMRKQHKRLNTYGYIGPGFGIFLEPRAIVNDATSVVEIEKKSKFNFSSKLGLGADYKFKGFFVGLEVGYVHSFTKIQNTPINAMTVMVGLKSDITRLGDKVVSVLGVDGSISGKQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM03</accession>
    <name>D7VM03_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipid A biosynthesis (KDO)2-(Lauroyl)-lipid IVA acyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">waaM</name>
        <name evidence="6" type="ORF">HMPREF0766_12000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001167.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12000"/>
    <dbReference type="EnsemblBacteria" id="EFK58008">
        <property type="protein sequence ID" value="EFK58008"/>
        <property type="gene ID" value="HMPREF0766_12000"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049421_4_1_10"/>
    <dbReference type="OrthoDB" id="1106624at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="288" mass="34525" checksum="0D8F60882E84E4B2" modified="2010-10-05" version="1">MKIKLLSGILFCLSILPFWVLYALSDLFYYLLFYGIKYRKKVVLENLKNSFPEKTEKERIMIAKRFYRFFPDLVVEAVKMATISKKEVLKRMELIDADEVYRHFNAGKAVIGVTAHYANWELGIHRLSLMTPNPVLIIYKPLNNISFNTLYNNIRSRFGAQMIPMKQILRAIIRLKKQPHISMFVADQTPVYQDSDYFLEFLNQETLVYTGTERIARMTHDPVVYCHIGRKEKRGYYYCKFTTLVEDVSLYAEHEITHLHNKFTEDIIKEKPEYWLWSHRRWKRKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM05</accession>
    <name>D7VM05_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">DNA ligase</fullName>
            <ecNumber evidence="10 11">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">ligA</name>
        <name evidence="13" type="ORF">HMPREF0766_12002</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="10 11"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001173.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12002"/>
    <dbReference type="EnsemblBacteria" id="EFK58010">
        <property type="protein sequence ID" value="EFK58010"/>
        <property type="gene ID" value="HMPREF0766_12002"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007764_2_0_10"/>
    <dbReference type="OrthoDB" id="241401at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033136">
        <property type="entry name" value="DNA_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004149">
        <property type="entry name" value="Znf_DNAligase_C4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03119">
        <property type="entry name" value="DNA_ligase_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01056">
        <property type="entry name" value="DNA_LIGASE_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="594"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="10">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="34"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="83"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFK58010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="673" mass="76826" checksum="05D85C8C47C162B3" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM55</accession>
    <name>D7VM55_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_12052</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001318.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK58060">
        <property type="protein sequence ID" value="EFK58060"/>
        <property type="gene ID" value="HMPREF0766_12052"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_13_2_10"/>
    <dbReference type="OrthoDB" id="514956at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107696" evidence="5">
        <location>
            <begin position="22"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="50"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="210"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="693" mass="77559" checksum="D56A7547A082A243" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMC0</accession>
    <name>D7VMC0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ATP synthase F0, A subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_12117</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12117"/>
    <dbReference type="EnsemblBacteria" id="EFK58125">
        <property type="protein sequence ID" value="EFK58125"/>
        <property type="gene ID" value="HMPREF0766_12117"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024619_2_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002825">
        <property type="entry name" value="Pept_S49_ser-pept_pro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01972">
        <property type="entry name" value="SDH_sah"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107051" evidence="3">
        <location>
            <begin position="26"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="4">
        <location>
            <begin position="351"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="450" mass="48828" checksum="5395CB8AA6BE971C" modified="2010-10-05" version="1">MNKFTKTFLTILFLMSCFAITAVQAQEVYHVRIHDEIGPAAWRTFDKATKRASELKSAYLLVELNTFGGAVNYADSIRSRLLNSPMKTVVYINHNAASAGALIAMASDYIYMQKGASIGAASVVDAKGEVLPEKYQSYMRGLMRATAEAKGRDPKIAEAFVDPSVSIPNLKPDGKLLTMTADEAVKAGVAKAEVSANKEIFIDLGIRKPTVTVHEVGMIDNIIGFLINPVVSGALILLIIGGIYAEMQTPGIGFALAVALIAGALFFAPLYMEGLAAHWEIALFFIGVILIALEIFVIPGFGVTGILGIICLVCGLAFSMVSNDYFDFKLAHPGMLFNSFLIVIGSMFLAVILMVIFGKNILKSSAFKRLVLEDEQKSDQGYTSSVSKADLLHKQGVAKTVLRPSGKIEIDGVWYDAVALDGFIDAGDLIYVEKHENYNLFVRKIEELKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VME8</accession>
    <name>D7VME8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">uspF</name>
        <name evidence="3" type="ORF">HMPREF0766_12145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001483.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12145"/>
    <dbReference type="EnsemblBacteria" id="EFK58153">
        <property type="protein sequence ID" value="EFK58153"/>
        <property type="gene ID" value="HMPREF0766_12145"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_2_10"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="8"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="157" mass="17129" checksum="47AB9799A51432EA" modified="2010-10-05" version="1">MTTVHPKFQRVLVAIDDSPCSLKAIEYAKEVTKLLKTSIALVTVVPPTTPASYGADPLLGQQPIIVPEVTEIQEKSAQEFLERISREFEEANEVFVFNKVGSVKQEILSVAQEWAADLIIMGSNGRTGFDHFISGSVSEGVIRKSLCPVMVIPGKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMG2</accession>
    <name>D7VMG2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001508.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12159"/>
    <dbReference type="EnsemblBacteria" id="EFK58167">
        <property type="protein sequence ID" value="EFK58167"/>
        <property type="gene ID" value="HMPREF0766_12159"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_4_1_10"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="210" mass="23807" checksum="3FB887F58833D815" modified="2010-10-05" version="1">MSLLEHLNWRYATKKMNGQQVAQEKVDYIIEAARLAPTSSGLQPYKIIAISDPKLKAKIQPIAYNQSQIVDASHLLIFAAYDEYTKQRVDEVFTQQEVERGLPAGFADDYKNQLFSSLSAREQQQQFEHAARQAYIGFGLAIAAAAEQKVDATPMEGFVNEQLDDLLELKKYGLKSVTILALGYRDTENDWLVNMKKVRKDVKDFVISLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMM2</accession>
    <name>D7VMM2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-sulfur cluster assembly accessory protein</fullName>
            <ecNumber evidence="3">3.1.21.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">erpA</name>
        <name evidence="3" type="ORF">HMPREF0766_12242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family. Ycf83 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.3" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992685.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12242"/>
    <dbReference type="EnsemblBacteria" id="EFK57169">
        <property type="protein sequence ID" value="EFK57169"/>
        <property type="gene ID" value="HMPREF0766_12242"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069054_5_1_10"/>
    <dbReference type="OrthoDB" id="1891602at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031108">
        <property type="entry name" value="ISCA_plant_cyanobact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47265">
        <property type="entry name" value="PTHR47265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="2">
        <location>
            <begin position="12"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="117" mass="12684" checksum="DC486272B3C907D7" modified="2010-10-05" version="1">MSTENIVEKAPLTLTEGAVKELKKLRDQQEISEDFGLRVGVEGGGCSGMSYILGFDQKKEGDSEYEIEGIRIFMNKAHGLYLAGMEVDFRNGLDARGFTFNNPNATSTCGCGSSFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMP4</accession>
    <name>D7VMP4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDSL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992720.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12264"/>
    <dbReference type="EnsemblBacteria" id="EFK57191">
        <property type="protein sequence ID" value="EFK57191"/>
        <property type="gene ID" value="HMPREF0766_12264"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065859_2_1_10"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01821">
        <property type="entry name" value="Rhamnogalacturan_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PTHR43695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="36"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="260" mass="29173" checksum="924C9AA608449505" modified="2010-10-05" version="1">MNYCTLKRGLSVLVMIAVIIGLYAFADKEPVTLYIIGDSTAANKTAKTYPETGWGMKLQELFNEQKVIVDNRALNGRSTASFKHDYNTKSHTVVNHWRLVLEKIKPGDYVFIEFGHNDEKIHKPTVGTSLEKFKANLTEYVEETRQKGAIPVLLTPIERRNWINGKLIETHGGYPDVTREVAKQLNVPLIDMQIKTNSLLSRLGEEGSVSLFNHLPPGHENYPKGIQDNTHLSPKGAEQLAKLVVDGIRELNLTLATALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMQ3</accession>
    <name>D7VMQ3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase, family 88</fullName>
            <ecNumber evidence="2">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12273"/>
    <dbReference type="EnsemblBacteria" id="EFK57200">
        <property type="protein sequence ID" value="EFK57200"/>
        <property type="gene ID" value="HMPREF0766_12273"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_446015_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107063" evidence="1">
        <location>
            <begin position="23"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="637" mass="72760" checksum="90DA517FA8836A85" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMT9</accession>
    <name>D7VMT9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG</name>
        <name evidence="1" type="ORF">HMPREF0766_12309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992795.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12309"/>
    <dbReference type="EnsemblBacteria" id="EFK57236">
        <property type="protein sequence ID" value="EFK57236"/>
        <property type="gene ID" value="HMPREF0766_12309"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_10"/>
    <dbReference type="OrthoDB" id="1294334at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="273" mass="28957" checksum="1C540DCA02F646B8" modified="2010-10-05" version="1">MNILEQFSLKGQVIVVTGGTGILGKSFVKALAEAGAKVVIIGRNQERADERVKLVETLGGEGLAIVADVLSESEMIAARDKIIEKWGTIDGLVNAAGGNIPGATIGPDQNLFDSKIEDTLKAIELNLNGTIIPTQVLGRVLAEKGKGSIINIASLASSSAITRVLGYNVAKCGIIGYTKWMATELSLRYGDKVRVNAIAPGVFLTEQNRTLLTNEDGTFTARAQRFLNKTPFSRLGDPSELEGALIFLLSQASGFINGETLYVDGGFNSWSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMU3</accession>
    <name>D7VMU3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, LacI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_12313</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992804.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12313"/>
    <dbReference type="EnsemblBacteria" id="EFK57240">
        <property type="protein sequence ID" value="EFK57240"/>
        <property type="gene ID" value="HMPREF0766_12313"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_0_10"/>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="343" mass="38207" checksum="304216830085FB1E" modified="2010-10-05" version="1">MSSITIKEIAKALNVSISTVSKALNDSHEIGEKTKKRVLEYAEAHHYKPNLLAQNLKTGKSNTIGVILTSINNPFCSQIIEGIQQHALKVGFEVIFMQSRENPEIERSCIETLMQRGVDGLLISPVDETSNQKLLEDIHDHNFPVVIFDRIQHNLETFKIGVNNFQGAYLATKHLIDSGRTKIVNITASRFGLSGERFKGYHQALTDAGIAFDDQFHIQCNMQNQEVLDVELKNAITRLMSAENKPDAILGSSDTITVTLLGVLAELGYSVPDELAVIGFSNIDFARSLNPALSTIRQPALEIGDMAMEKLMKFIAKKNWHQVQIETTELDTILTFRKSSIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMY1</accession>
    <name>D7VMY1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, BlaI/MecI/CopY family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992866.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12351"/>
    <dbReference type="EnsemblBacteria" id="EFK57278">
        <property type="protein sequence ID" value="EFK57278"/>
        <property type="gene ID" value="HMPREF0766_12351"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119090_4_0_10"/>
    <dbReference type="OrthoDB" id="2027769at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="131" mass="15256" checksum="4080B73CFFFE2DB9" modified="2010-10-05" version="1">MNSNNIETSLSKKEEELMDYIWQSGKPFLKDIIECYPDPKPATTTIATLLKRLQDKGVIDYETFGNSRRYFPLIKKDAYFSNQMSGMIKQFFNDSALQFASFFTTSSNLSDKELESLRKIVDQELKKRKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN16</accession>
    <name>D7VN16_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heavy metal efflux pump, CzcA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">czcA</name>
        <name evidence="4" type="ORF">HMPREF0766_12386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992912.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12386"/>
    <dbReference type="EnsemblBacteria" id="EFK57313">
        <property type="protein sequence ID" value="EFK57313"/>
        <property type="gene ID" value="HMPREF0766_12386"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_10"/>
    <dbReference type="OrthoDB" id="91817at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004763">
        <property type="entry name" value="CzcA/CusA/SilA/NccA/HelA/CnrA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00914">
        <property type="entry name" value="2A0601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="533"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="869"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="895"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="921"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="966"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="998"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1030" mass="115159" checksum="03510D88A26E278D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN80</accession>
    <name>D7VN80_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992994.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12450"/>
    <dbReference type="EnsemblBacteria" id="EFK57377">
        <property type="protein sequence ID" value="EFK57377"/>
        <property type="gene ID" value="HMPREF0766_12450"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2920432_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="61" mass="7263" checksum="4B071084A2CD31B2" modified="2010-10-05" version="1">MKKIDLTFTEFQYLVLDGDDLPLFTFSDRMEAEKFKDECSNPNDFYTILKIPVNPNWKVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNL6</accession>
    <name>D7VNL6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993171.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12586"/>
    <dbReference type="EnsemblBacteria" id="EFK57513">
        <property type="protein sequence ID" value="EFK57513"/>
        <property type="gene ID" value="HMPREF0766_12586"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032FGC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184331_0_0_10"/>
    <dbReference type="OrthoDB" id="2050508at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="94" mass="11220" checksum="F7F28AC8F3659464" modified="2010-10-05" version="1">MKKLRANMDRYFDRLDERWRALPLRKQRQYTLYFFVVYLLLTVVVIGKVMYDTSKSGNNMVIKHIENPVLKNGNPARLPDSVSTILKNQIYERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP29</accession>
    <name>D7VP29_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">msrA</name>
        <name evidence="6" type="ORF">HMPREF0766_12749</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993440.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12749"/>
    <dbReference type="EnsemblBacteria" id="EFK57676">
        <property type="protein sequence ID" value="EFK57676"/>
        <property type="gene ID" value="HMPREF0766_12749"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_10_0_10"/>
    <dbReference type="OrthoDB" id="1554384at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="3"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK57676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="171" mass="19573" checksum="7AAEBD0DFDA0F1C1" modified="2010-10-05" version="1">MLVTFGGGCFWCTEVIFQNTDGVKSVLPGYMGGKNDHPTYEQVCTGTTDHVEVVQLDIDESKVSFEDLLKIFFKTHNPTTLNRQGNDVGTQYRSVVFYHNEEQKEKAERFIQQLDAEHVYADPVVTAVEPASTFWEAEDYHHNYFNSHPENPFCSVVIAPKLQKFLKEFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP77</accession>
    <name>D7VP77_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase family protein</fullName>
            <ecNumber evidence="2">4.4.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gloA</name>
        <name evidence="2" type="ORF">HMPREF0766_12797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993517.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12797"/>
    <dbReference type="EnsemblBacteria" id="EFK57724">
        <property type="protein sequence ID" value="EFK57724"/>
        <property type="gene ID" value="HMPREF0766_12797"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_2_4_10"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="130" mass="15078" checksum="0CA4F4EA927E60E5" modified="2010-10-05" version="1">MHLSLVKIHHVAVICSDYHISKKFYTEILGMHIIQETYRKERDSYKLDLAIGSEYIIELFSFPNPPPRPSHPEACGLRHLSFLVENIKEEVAKLDMAGIPHEQIRTDELTNKEFVFFADPDGLPIELYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPA3</accession>
    <name>D7VPA3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993579.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12823"/>
    <dbReference type="EnsemblBacteria" id="EFK57750">
        <property type="protein sequence ID" value="EFK57750"/>
        <property type="gene ID" value="HMPREF0766_12823"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7I5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085065_1_0_10"/>
    <dbReference type="OrthoDB" id="1452595at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025632">
        <property type="entry name" value="DUF4290"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14123">
        <property type="entry name" value="DUF4290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="263" mass="30201" checksum="C0854674F11F3F46" modified="2010-10-05" version="1">MNFDYNSTRPKLILAEYGRNVQNMVDYISSLPTKEERNRHAQVVIDMMGVLNPHLRDVADFKHKLWDHLQIISDFKIDVDSPYPIQSRENVKHQPEMLGYPQHNIRFKHYGHTVETMVSKARLITDETKRNQMILSIANFMKMAYLTWNKDSVSDEQILQDLKELSKGELFLPEGTVLTKLDFKTPPPGSRVKSQTPSSGGSNNNNNNNKGSYQQKSNNNNNKKPGGFVKRNNNNNNSGGPKKSYHNNNNNNNNNHSNNYKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPA6</accession>
    <name>D7VPA6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993584.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12826"/>
    <dbReference type="EnsemblBacteria" id="EFK57753">
        <property type="protein sequence ID" value="EFK57753"/>
        <property type="gene ID" value="HMPREF0766_12826"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057100_1_1_10"/>
    <dbReference type="OrthoDB" id="503666at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021428">
        <property type="entry name" value="DUF3078"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11276">
        <property type="entry name" value="DUF3078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107759" evidence="1">
        <location>
            <begin position="22"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="298" mass="33811" checksum="529D660700B3A1F0" modified="2010-10-05" version="1">MKKLKLTIMLLLSAFSIATYAQQEGADSTRLWTIKGENTFLINQSSFSNWAAGGVNSFAGNLIFNYDFNYKKDRWSWDNKVLAAYGQTFQKETDWRKNDDRFAISSLLGYQAKERWLYTFFMNFNTQFAKGYKYDSNNARTLLSTAFAPAYLSFGPGMAYKESDNFKINISPAAARFVFVTNDSLSNIGAFGVDPGKKSRFEFGASLDAYYKKEIMENITFENILKLYSNYLEDPQNVDVDYTANLVMKVNKWITVNAGVQLIYDDNTLIPKDNGAPGSERPALQVKQILGAGITYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPF7</accession>
    <name>D7VPF7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12877</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993665.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12877"/>
    <dbReference type="EnsemblBacteria" id="EFK57804">
        <property type="protein sequence ID" value="EFK57804"/>
        <property type="gene ID" value="HMPREF0766_12877"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_14_1_10"/>
    <dbReference type="OrthoDB" id="1958442at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="138"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="235" mass="27211" checksum="B46F1EC29261A800" modified="2010-10-05" version="1">MNCIIVDDEPIARIGIEKLLKNIENLELTGSFENAYTASLFIRENAVDLIFLDIQMPGLNGLEFAKQVGNTTLIIFTTAFAEFAIDSYEVDAIDYLVKPIQPNRFKKAVTKAISYHKMLVNEEKNLLTDQIEGEFVFIKSDRRYFKVVFKDILFIEGLKDYVIIHTENQKLITHTNLKNAHTLLPSKNFLRVNRSYIINKDRIDSFSNNDVFIGDNEISIGNFYREDFLKEIMKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPG7</accession>
    <name>D7VPG7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="8">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">IMP cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">purH</name>
        <name evidence="10" type="ORF">HMPREF0766_12887</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="8"/>
    <dbReference type="EC" id="3.5.4.10" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993693.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12887"/>
    <dbReference type="EnsemblBacteria" id="EFK57814">
        <property type="protein sequence ID" value="EFK57814"/>
        <property type="gene ID" value="HMPREF0766_12887"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016316_5_2_10"/>
    <dbReference type="OrthoDB" id="1049662at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK57814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="508" mass="55923" checksum="F0EFE7044E9197EF" modified="2010-10-05" version="1">MSHPVKIKNALVSVYYKDNLAPLIQLLHKHGVTFYSTGGTEAFIKDLGIGVVPVEDLTSYPSILGGRVKTLHPKVFGGILARRPLEDDQKQLEQYEIPEIDLVIVDLYPFEETVASGAQEQDIIEKIDIGGISLIRAAAKNFNDVVILSSKNDYQELENILAAQEGSTTLEQRKEFAKRAFNTSSHYDTAIFNYFNQENPLDVFKQSEQVAQVLRYGENPHQKGVFYGNLDAMFDKLNGKELSYNNLVDVDAAVSIIDEFEEPTFAILKHTNACGVASRPTVKQAWTDALACDPVSAFGGVLITNREVDAETATEINNLFFEVLIAPAYSEEAKAILTAKKNRIILVRKDVKLPQQQFKTLLNGVIQQDKDNTVENPDQMTSVTNVKPTAEQLEDLYFANKIVKHTKSNTIVFAKDGQLLASGVGQTSRVDALKQAIEKAKSFGFDLNGSSMASDAFFPFPDCVELAAEAGIAAVLQPGGSIKDQLSIDMANEKGLAMVTTGVRHFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPI0</accession>
    <name>D7VPI0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993725.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12900"/>
    <dbReference type="EnsemblBacteria" id="EFK57827">
        <property type="protein sequence ID" value="EFK57827"/>
        <property type="gene ID" value="HMPREF0766_12900"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4895">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182218_0_0_10"/>
    <dbReference type="OrthoDB" id="2026211at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019240">
        <property type="entry name" value="DUF2196"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40069">
        <property type="entry name" value="PTHR40069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09962">
        <property type="entry name" value="DUF2196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03833">
        <property type="entry name" value="TIGR03833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="66" mass="7192" checksum="A66B3B4D8C008561" modified="2010-10-05" version="1">MDGTNRADIKPGILVNIILKKDQRTGALTEGIVKDILTSSSYHSRGIKVRLTDGQVGRVAEIIDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPI2</accession>
    <name>D7VPI2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enolase</fullName>
            <ecNumber evidence="8">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">eno</name>
        <name evidence="13" type="ORF">HMPREF0766_12902</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell surface</location>
        </subcellularLocation>
        <text evidence="8">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993729.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12902"/>
    <dbReference type="EnsemblBacteria" id="EFK57829">
        <property type="protein sequence ID" value="EFK57829"/>
        <property type="gene ID" value="HMPREF0766_12902"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_2_1_10"/>
    <dbReference type="OrthoDB" id="533698at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="11">
        <location>
            <begin position="139"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="368"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 9">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="8">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFK57829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="433" mass="46699" checksum="0F7641CE5C97047A" modified="2010-10-05" version="1">MSLIIDVRARQILDSRGNPTIEVDVTTQNGFTGRAAVPSGASTGAHEAVELRDGDKKKYLGKGVLKAVENVNTKIAKALEGVDVFEQNAIDKLMIDLDGTENKGKLGANAILGVSLAVAKAAAQESGQPLYRYVGGVNANTLPIPMMNIINGGSHSDAPIAFQEFMIMPVGAPSFSEALRWGTEVFHNLKKILHDRGLSTAVGDEGGFAPTFEGTEDAIETVLKAISAAGYKPGKDICLALDCASSEFFKSNKYDYTKFEGAKGAVRTIEQQVDYLAELTEKYPIISIEDGMAEDDWKGWKLLTDKIGDRVQLVGDDLFVTNTKRLQQGIDQHTGNSILVKVNQIGSLTETINAVSLAQTNGYTSVMSHRSGETEDTTIADLAVALNCGQIKTGSASRSDRIAKYNQLLRIEEELGANARFIGKDFKYAIKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPL4</accession>
    <name>D7VPL4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycoamylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993789.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12934"/>
    <dbReference type="EnsemblBacteria" id="EFK57861">
        <property type="protein sequence ID" value="EFK57861"/>
        <property type="gene ID" value="HMPREF0766_12934"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023287_0_1_10"/>
    <dbReference type="OrthoDB" id="1384939at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019282">
        <property type="entry name" value="Glycoamylase-like_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016883">
        <property type="entry name" value="UCP028431"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10091">
        <property type="entry name" value="Glycoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028431">
        <property type="entry name" value="UCP028431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoamylase-like" evidence="1">
        <location>
            <begin position="216"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="452" mass="51168" checksum="518F0CEC05CFA870" modified="2010-10-05" version="1">MKALIYTFFIPLLILQSCFSNQEQKHTDSQSDSKDSLSTDSLLTLIQKQTFRYFWDGAEPTSGMARERIHIDGAYPENDQNVITIGGSGFGIMAIITGIERQFISKEEGAKRLDHIMDYLGRIDRFKGAWSHWYYGETGKAKSFSQQDDGADIVETAFMAEALIIVREYYKNGSETEKAIANKADALWKGIEWNFFRNGKDVLFWHWSPTYGWGMNHAIQGYDECLITYILAASSPTHPIPASTYHKGWARDGAIVTDAKKYNIPMILKHNAPNGGVGPLFWEHYSYLGLDPKGLKDQYANYWDVVVNHSKINIAHAEQNPNKYEGYGADKGWGLTASYSVKGYDAHHPDNDHGVISPTAALSSMPYTPKESIAFARYLNQHLGQKVWGQYGFYDAYSETDNWFPQRYLAIDQGPIVVMIENYRTGLFWKLFMGAPDVQKGLKGLGFTSPHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPP3</accession>
    <name>D7VPP3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bacteroidetes-specific putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993828.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12963"/>
    <dbReference type="EnsemblBacteria" id="EFK57890">
        <property type="protein sequence ID" value="EFK57890"/>
        <property type="gene ID" value="HMPREF0766_12963"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068235_0_1_10"/>
    <dbReference type="OrthoDB" id="1677536at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019861">
        <property type="entry name" value="PorP/SprF_Bacteroidetes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11751">
        <property type="entry name" value="PorP_SprF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03519">
        <property type="entry name" value="T9SS_PorP_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="300" mass="33245" checksum="5CB4FCB88F6C5155" modified="2010-10-05" version="1">MKSKYILTVTVLLLFTNMSRGQQYIDPALSGSFGKVLNPSANVLLDKGEGDAMMVYRYQWAGLEGSPKSLWFTGNIGVGNAGIIMGINAKQFRIGVERNTEISGSFTKRLQISESEYLGLGANLGYTHQQGDFSPLDPGDPAFQNVKYGTLLYGLSATFISPNRYYVGFSMPKAIFGAKDSQYVRQFGKDNTFYLSGGIVIPLNDGFQLRPNLLISYREVTGLLFDASAMFYLHPKVGIGAGYRQRGDLMGMAEFNLGKLRVGYSYQQNLKNKDLNRYITNSTHELGIAIRFGKDNFSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ11</accession>
    <name>D7VQ11_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_13065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993983.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13065"/>
    <dbReference type="EnsemblBacteria" id="EFK55862">
        <property type="protein sequence ID" value="EFK55862"/>
        <property type="gene ID" value="HMPREF0766_13065"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_640667_0_0_10"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107134" evidence="6">
        <location>
            <begin position="31"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA" evidence="7">
        <location>
            <begin position="39"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK55862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="438" mass="48670" checksum="ACB08B57F0A5F2E1" modified="2010-10-05" version="1">MESNFLRRDFLKAGAAVAGTAALSSMPVSAVFAAGSDIIKVALIGCGGRGTGAAFDAFASGQNIRLVAMADAFKDNLDSTYNTLKEKFQDKIDIPDSRKYVGFDGYKSAIKDADVVILTTPPGFRPIHFEEAVKQGKHVFMEKPVATDLPGIRRVLAAAAEAKRKKLNVVVGLQRRYQTNYREVIKRVQDGAIGDVVSGQVYWNSGGVWVRPRKPGMTEMEYQMRNWYYFNWLCGDHIVEQHVHNIDIANWIKGKYPVSIQGTGSQAFRKGKDYGEIYDNFAVELTYDDNSVVYSQCRHFEGISNRVDETFQASKGRTYLSAGGQGVLWDANGKEIYRHDPKGNPNPYQQEHKELFEAIAKGEYKFDNAEYGAYSTLTGIIGRIACYTGKTIKWDKALESNVDLQPATYAWDASPKILPNADGLYPVAVPGQNTNLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ71</accession>
    <name>D7VQ71_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994075.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13125"/>
    <dbReference type="EnsemblBacteria" id="EFK55922">
        <property type="protein sequence ID" value="EFK55922"/>
        <property type="gene ID" value="HMPREF0766_13125"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080945_3_0_10"/>
    <dbReference type="OrthoDB" id="1564394at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009282">
        <property type="entry name" value="DUF937"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06078">
        <property type="entry name" value="DUF937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="202" mass="20920" checksum="45050215D17B7627" modified="2010-10-05" version="1">MGMIDLITGGIGTKVITALAGKLGISETKAKWMVAIAVPLMIAALKYNSSKKSEQAESLNNALDNKHTGDALDRVDQIVEDGPSEDDDKIINHMFGKNSDQVKNEIASKTGISSETVGTVLSTLAPIVMAYVGKEKAAQSNSGGIGDLLGGLLNGGGNDNASANGQQQQSSGGGIADLVSGFFDKNKDGNFLDDIAGMFTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ77</accession>
    <name>D7VQ77_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, aldo/keto reductase family protein</fullName>
            <ecNumber evidence="3">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994082.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13131"/>
    <dbReference type="EnsemblBacteria" id="EFK55928">
        <property type="protein sequence ID" value="EFK55928"/>
        <property type="gene ID" value="HMPREF0766_13131"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_10"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="16"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK55928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="329" mass="36211" checksum="D50D30E2D405C195" modified="2010-10-05" version="1">MKYRKIGKSDLQLSIITFGAWAAGGWMWGSTDRNEAIKAIQAGLEEGMTSIDTAPIYGQGTSEEIVGEAIKGLSRDKIQILTKFGMRWDTDQGDLVGPSKNNQGQDITIYKYAAKDSVIYECEQSLKRLGTDYIDLYQIHWNDKTTAIEETFEAVARLIEQGKIRYAGVCNYDKEQIARAASVCPVISNQIPYSMVNRGIEKETVPYCIANDIGILAYSPMERGLLTGKMKPGQQFGAGDHRANLPSFTDDSIARTNAFLKTIEPIADKYDVTLGQLVLGWTVAQPGITIALAGARNASQTISNARAGDLEIEQQDIDTITKELHTMLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQA8</accession>
    <name>D7VQA8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fklB</name>
        <name evidence="8" type="ORF">HMPREF0766_13162</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994145.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13162"/>
    <dbReference type="EnsemblBacteria" id="EFK55959">
        <property type="protein sequence ID" value="EFK55959"/>
        <property type="gene ID" value="HMPREF0766_13162"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0545">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013615_0_2_10"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000774">
        <property type="entry name" value="PPIase_FKBP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036944">
        <property type="entry name" value="PPIase_FKBP_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01346">
        <property type="entry name" value="FKBP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107235" description="Peptidyl-prolyl cis-trans isomerase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="155"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK55959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="257" mass="27521" checksum="02B8514662B470E3" modified="2010-10-05" version="1">MRKVLAVGFLTALTLCAGAQVKKKNTTPAKKSTSPSGPAQQGIVLKNSGDSLSYALGFDIGSSVKPMELPLNIELMKKGLEEALKGSNGKFTKEQNVEIIRNGIQKASDAKNAVALKAENEFFAKNKTKAGVITTPEGLQYEILTKTEGAKPAREDEIVAHYKGTLLDGKTFDSSYDRGTPLTLSLQSVIEGWKLGIPLMSVGSKYRFYIPSKLGYGPNGSGPIPGNSTLIFDIELLEIKKAETEGVPVAEVADDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQE9</accession>
    <name>D7VQE9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Di-heme cytochrome C peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mauG</name>
        <name evidence="6" type="ORF">HMPREF0766_13203</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994243.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13203"/>
    <dbReference type="EnsemblBacteria" id="EFK56000">
        <property type="protein sequence ID" value="EFK56000"/>
        <property type="gene ID" value="HMPREF0766_13203"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034652_3_2_10"/>
    <dbReference type="OrthoDB" id="52724at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004852">
        <property type="entry name" value="Di-haem_cyt_c_peroxidsae"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03150">
        <property type="entry name" value="CCP_MauG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="76"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="228"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK56000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="380" mass="43547" checksum="D3394108C395E2DE" modified="2010-10-05" version="1">MRVGIVLGVIISVVSLLSFKGFESQHEQIGVDSLRSLYQRPVGEWPRPVIDSGVKWEEFKSLPNFDTGYFAMMERPEVILGKNLFFDPILSGSNQISCSSCHNPQTSWADKVQVPVGHDHLSGNRNTPSLLNAHSRKTFFWDGRAATLEEQVLGPIQAHNEMAMDASQLPAKLQQYKAYRELFQKAYGTDVITFNMITQSLAAFQNTISSRRSRFDRFLDGEYKYLSDQEISGLHLFRTKARCMNCHNGQYFTDEDFHNIGLTYYKRKYEDLGRYHVTHNPDDVGKFRTPSLRDVMSTNPWMHNGLFWDITGLLNMYNSGMQMNSATAEQKAKDPMYPVTDPLMKPLKLTKEEIQDVAAFLNAITATDYKMRRPDKLPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQF1</accession>
    <name>D7VQF1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994247.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13205"/>
    <dbReference type="EnsemblBacteria" id="EFK56002">
        <property type="protein sequence ID" value="EFK56002"/>
        <property type="gene ID" value="HMPREF0766_13205"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1634324_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="162" mass="18438" checksum="0337944BE2904FE5" modified="2010-10-05" version="1">MKTKLIISFFLFFTFYSCEKENQNIDSSKISPEELQLNKLIKNSDLTKKVISSRKFELKNGKLFQVSKFASNIKYLYEVDEGIYIGDGIAIEHCNDLFNGDPGNQISLLTYYSGQLYYGEMAIYGKSTIGTSSGTQAQYFECWIDHDPIGTVKRISSSSPWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQU1</accession>
    <name>D7VQU1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13345"/>
    <dbReference type="EnsemblBacteria" id="EFK56142">
        <property type="protein sequence ID" value="EFK56142"/>
        <property type="gene ID" value="HMPREF0766_13345"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3030115_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="55" mass="6147" checksum="AB607A1F425A50D2" modified="2010-10-05" version="1">MWFPFSDHRSPASDFPEIALSGYSLLISPFFITMKNSNTVSIVVTVCYISCGLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQY7</accession>
    <name>D7VQY7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TonB-dependent receptor plug domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994531.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13391"/>
    <dbReference type="EnsemblBacteria" id="EFK56188">
        <property type="protein sequence ID" value="EFK56188"/>
        <property type="gene ID" value="HMPREF0766_13391"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_3_0_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plug" evidence="1">
        <location>
            <begin position="240"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="360" mass="39381" checksum="EB35326DF2C17814" modified="2010-10-05" version="1">MKNTLGLKDHAILQCDRYKLFNLKKLLMITKISCALLFISCFQLKAETFSQTISLNARSVKLKKAFKHIEQVSNYVVLYNQNDLKNTKPVKIAASNVPLTTFLDMLLKDQPFEYKIEDKTILINSRKEKKNQFQWEPANKFDLYELIQMSIRGKVQNEKGEGLPGVTVTVKGSSFKTSTDQAGAFQLNTVNKGATLIFSAVGYESTERILSDASFLNVQMKETISDLDEVVVVGFGTQKKENLTGAVSSVKFENQLGDRPVNTIGTVLQGAAPGLQVTQTTGEPGGGFSMNVRGTTSINGGTPLILVDNVPFEGGLNLLNPADIESVSILKDAASASIYGARSAYGVILITTKKAKEIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR74</accession>
    <name>D7VR74_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994645.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13478"/>
    <dbReference type="EnsemblBacteria" id="EFK56275">
        <property type="protein sequence ID" value="EFK56275"/>
        <property type="gene ID" value="HMPREF0766_13478"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_31_8_10"/>
    <dbReference type="OrthoDB" id="2040098at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="70" mass="7797" checksum="D765EBDB497FE8B2" modified="2010-10-05" version="1">MPIIVNLDVMMAKRKMSLNELSDKVELTLSNLSILKTGKAKAIRFSTLEAICKALNCQPADILEYIEDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRD7</accession>
    <name>D7VRD7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TonB-dependent receptor plug domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13541</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994726.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13541"/>
    <dbReference type="EnsemblBacteria" id="EFK56338">
        <property type="protein sequence ID" value="EFK56338"/>
        <property type="gene ID" value="HMPREF0766_13541"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017617_0_0_10"/>
    <dbReference type="OrthoDB" id="173242at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041700">
        <property type="entry name" value="OMP_b-brl_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14905">
        <property type="entry name" value="OMP_b-brl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107832" evidence="1">
        <location>
            <begin position="22"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="144"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl_3" evidence="3">
        <location>
            <begin position="393"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="803" mass="91194" checksum="F6CF96F9A071BCEF" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRG7</accession>
    <name>D7VRG7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, 2-nitropropane dioxygenase family protein</fullName>
            <ecNumber evidence="2">1.13.12.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ncd-2</name>
        <name evidence="2" type="ORF">HMPREF0766_13571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.12.16" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994763.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13571"/>
    <dbReference type="EnsemblBacteria" id="EFK56368">
        <property type="protein sequence ID" value="EFK56368"/>
        <property type="gene ID" value="HMPREF0766_13571"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_5_1_10"/>
    <dbReference type="OrthoDB" id="275153at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="6"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="355" mass="38441" checksum="8CF037A8F7ADEF5B" modified="2010-10-05" version="1">MKWKNEITELLGIIHPIVQAPMLGVTSPEMVAAASAAGCLGSLALGDLTAEQCSAAIRQTRALTSEPFAVNFFAHAIPPVTDQLISKYNTARSFIQDLAQKHNLKAELPSLEQLQLHSYHQQIAAILEEKCPIVSFTFGNPDAAVISLFKQNGSILIGTCTSLDEALALERSGIDIICVQGIEAGGHRGSFIDDSLPLVGGFSLLSQVLEHVRVPVIYAGGIYNARSLRAVHTLGACGFQVGSLLLTAKESILKPFEKELLQQLKSKDVVLTNSFTGRYARGIRNLFSKEAEASGNILPYPYQNKLTAPLRLASKTNQNPDFVSIWVGQSPYPFSTASTAEILRNLIHEVESQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRN6</accession>
    <name>D7VRN6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56437">
        <property type="protein sequence ID" value="EFK56437"/>
        <property type="gene ID" value="HMPREF0766_13640"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3276828_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="41" mass="4919" checksum="D2D8BCD977B4A666" modified="2010-10-05" version="1">MIKKQKVKQTQLQKNPYLYYVTNWGFVNPTTTETPSETKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRS0</accession>
    <name>D7VRS0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994980.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13674"/>
    <dbReference type="EnsemblBacteria" id="EFK56471">
        <property type="protein sequence ID" value="EFK56471"/>
        <property type="gene ID" value="HMPREF0766_13674"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052345_4_0_10"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="230"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="335" mass="39519" checksum="A6E83EE17302F3CC" modified="2010-10-05" version="1">MENPRTQIIHFFEIDTLPTTESPVQNYQTKVLDNDLGQFSTGYIYDCEEFVVRDYNFSYKKDYKHHFITKGNSYIEISFLFNPIAVQDTINTKPNTYLPFHSYVYYTPPKSAVQIEFKKDVAYHNLDVYVSFSFFNEWADTNPAIKEFVRTINENQYAVLFDRGIPLNKEIFSLLDEIRNCELEGVSRFYFIKSKILYLLSILFKLGEYETVVPESAIVIWRKEEIHILQKVEEFIVRNSEQFFTITFLSRKFAINEFKLKKGFKQLYGKGIFEYANSVRMEKARHLIEQQDYSLKEIAYQIGYSTPSSFSVAFKNEYGMSPALFRKQIMALSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS28</accession>
    <name>D7VS28_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995251.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13782"/>
    <dbReference type="EnsemblBacteria" id="EFK56579">
        <property type="protein sequence ID" value="EFK56579"/>
        <property type="gene ID" value="HMPREF0766_13782"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_2_5_10"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="9"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="151" mass="17627" checksum="3EF8ADDBE56FE217" modified="2010-10-05" version="1">MELKENIIRFHHVCIKAQDITETVTFYQQFGFEEVHHWSLPEFQLEMCVMLYHKGLDCHLEICDQNASIPTQGRKRYPEEEYVENALLHLCFMVKDVADAMQQAISYGAKPLSKEVWEINLKNEKKSVTVNNGLVYSPNGEVIEFIKELSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS35</accession>
    <name>D7VS35_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13789"/>
    <dbReference type="EnsemblBacteria" id="EFK56586">
        <property type="protein sequence ID" value="EFK56586"/>
        <property type="gene ID" value="HMPREF0766_13789"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3296708_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="40" mass="4701" checksum="D0A3391C5578252A" modified="2010-10-05" version="1">MINNFGSIYFFKTTFMKNCLVIDWILKIVICQLGRLVVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS36</accession>
    <name>D7VS36_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sigma-70, region 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rpoD</name>
        <name evidence="9" type="ORF">HMPREF0766_13790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995274.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13790"/>
    <dbReference type="EnsemblBacteria" id="EFK56587">
        <property type="protein sequence ID" value="EFK56587"/>
        <property type="gene ID" value="HMPREF0766_13790"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_3_5_10"/>
    <dbReference type="OrthoDB" id="1565734at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r1_2" evidence="5">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="56"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="6">
        <location>
            <begin position="135"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="222"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK56587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="286" mass="32623" checksum="7AD38FD176816268" modified="2010-10-05" version="1">MRQLKITQSITNRESQSLDKYLHEIGKVDLITAEEEVILAQRIREGDQVALEKLTKTNLRFVVSVAKQYQNQGLTLGDLINEGNLGLIKAAKRFDETKGFKFISYAVWWIRQSILQAIAEQSRIVRLPLNQVGSLSKISKAFSKLEQEYEREPSPEELADILETTVDKVSDTLSNSGRHVSMDAPFVQGEENTLLDVLENHDPDTDSSLIDESLSEEIKRSLATLTEREREIIVLFFGLGSNHQLSLEEIGEKFNLTRERVRQIKDKALQRLRHTSRSKILKSYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS89</accession>
    <name>D7VS89_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995413.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13843"/>
    <dbReference type="EnsemblBacteria" id="EFK56640">
        <property type="protein sequence ID" value="EFK56640"/>
        <property type="gene ID" value="HMPREF0766_13843"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1642651_0_0_10"/>
    <dbReference type="OrthoDB" id="1884968at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="161" mass="18311" checksum="53BE8D8D5E7F9071" modified="2010-10-05" version="1">MSRLYIVIFLSLFSCIPGAGAQIINIGYKYEERSMFQTTINIPFLMDKNKPYEYMAGLDYTTKNVLAPSGITPQLTGGYYIIDDKRKSNILSLQLSAGYLFDLNKNFQNQVRLSPHLYFELNGIFNFKAGYDFLMPLEKGYPYVSIGLGGLLSLRHMNIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSR6</accession>
    <name>D7VSR6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PBS lyase HEAT-like repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995740.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14020"/>
    <dbReference type="EnsemblBacteria" id="EFK56817">
        <property type="protein sequence ID" value="EFK56817"/>
        <property type="gene ID" value="HMPREF0766_14020"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008672_0_0_10"/>
    <dbReference type="OrthoDB" id="1452706at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005672185" evidence="1">
        <location>
            <begin position="21"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1080" evidence="2">
        <location>
            <begin position="728"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1080" evidence="2">
        <location>
            <begin position="945"/>
            <end position="1131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1133" mass="122435" checksum="32F6281B4E48DFC6" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VST9</accession>
    <name>D7VST9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UvrD_C_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995800.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14043"/>
    <dbReference type="EnsemblBacteria" id="EFK56840">
        <property type="protein sequence ID" value="EFK56840"/>
        <property type="gene ID" value="HMPREF0766_14043"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017039_0_0_10"/>
    <dbReference type="OrthoDB" id="961809at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD_C_2" evidence="1">
        <location>
            <begin position="415"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="473" mass="54448" checksum="4C7588CF70907FFE" modified="2010-10-05" version="1">MHIQDLLIQNFHWPPTPQQKTAFSLLDQFLSTFDRQQVFIMKGYAGTGKTAIISSVVKTLPQLRKKSVLLAPTGRAAKVMSYYSGRKAFTIHKKIYRKKTSIAFNMDFGLAENLHEDTLFIVDEASMISNESVNIFSKSLLHDLIRYVQAGKNCSLLFVGDTAQLPPVGLLQSPALDAEYLRDEFYLHTFGFELTDVVRQAKSSGILFNATKIRQEIKIEEEKNDYPFPQFVTKGFGDIFQMTGEKLVEGLHYAYDKFGLENTLVVCRSNKSANLYNQNIRNRILFRDEELTGGDLIMVVRNNYYWLTENNEQNKSGFIANGDMAEVRKVGNIHEQHGFRFADVTLEFSASEEEDPVTCRVILDSLYSDSPNLPYEQQQQLYEAIAKDYEDIFSKKDRMEAIKKDPYYNALQIKFAYAITCHKAQGGQWEAVFVDQGYMNDDMLTTEFLRWLYTALTRATKELFLVNFNEKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSZ0</accession>
    <name>D7VSZ0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995889.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14094"/>
    <dbReference type="EnsemblBacteria" id="EFK56891">
        <property type="protein sequence ID" value="EFK56891"/>
        <property type="gene ID" value="HMPREF0766_14094"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031QVV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1438747_0_0_10"/>
    <dbReference type="OrthoDB" id="1350391at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="188" mass="21502" checksum="E3E32DDB2D8E9A5F" modified="2010-10-05" version="1">MIRKIIGIVIIILSMYSAYGQQINVNITQENKKVAAEGDRYTLRKLPFTFQVEVSGTDAFLIGATTDDDVYRSAIGEADLEVEWFENSGMAEGRFNAEQSLFISNDAPSYWYFTAADDHRFDRDPKGTPDHWTANRTVAKIDLLALDKQVSLKDIQTPLYLVFYIATHDEDYNVVDKKILYKAELVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT01</accession>
    <name>D7VT01_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995922.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14105"/>
    <dbReference type="EnsemblBacteria" id="EFK56902">
        <property type="protein sequence ID" value="EFK56902"/>
        <property type="gene ID" value="HMPREF0766_14105"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZC1V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066640_0_0_10"/>
    <dbReference type="OrthoDB" id="1404931at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107550" evidence="1">
        <location>
            <begin position="20"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="356" mass="41728" checksum="2ED2DFC774AE24B7" modified="2010-10-05" version="1">MKKYIIIILMVLSAVQLSAQHPNDPRYKKYEGRYGGNDGICLFEDGHFLLYGYATAVFGSYRFEKDYLLFCPDKPELFQVYAYENKSIGDSVRINFTGFENGATFARFDKDSIRRVFNEDANCFDAPFVYNGPLRFRQLSLSQYASEEEEDLQNPNTSWLYIIDPNYNDFIFVYNKPQSVYQDFAAVISGQDGELCLKKDGYLDRQGYPCRLNIKEDKEWPEIVKWKDQYFENKNKSDAVFANSHYNSFPAPDSNVYNYDINTNQYISKDYLENEEYFKQNEYSDDRSLRKYNKLQPNRREPFDYKQQTIASESIFYTTCEEPDKSYKYKGLKKVDSANDEAIPATTVPVPMPPNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT03</accession>
    <name>D7VT03_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RDD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_14107</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995927.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14107"/>
    <dbReference type="EnsemblBacteria" id="EFK56904">
        <property type="protein sequence ID" value="EFK56904"/>
        <property type="gene ID" value="HMPREF0766_14107"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1299088_0_0_10"/>
    <dbReference type="OrthoDB" id="1341696at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031493">
        <property type="entry name" value="Zinc_ribbon_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17032">
        <property type="entry name" value="zinc_ribbon_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="zinc_ribbon_15" evidence="7">
        <location>
            <begin position="20"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="90"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK56904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="212" mass="24049" checksum="4BE5E8CA2686038E" modified="2010-10-05" version="1">MLVIFGTKSVGKTVKTGEFECVRCNAHRPYQLKQNQKFFSLFFIPVIPLGKLGDTLECSFCKTAYIPSTVLSASEYTSSTTVIDSLEAPLASVGKRLGSYLIDMIVLTLLNFPLAFLAKHLPDYFDNKFYLLFFPLWILYFFMMELLFKGTVGKKALSVIVVSDRQDRKLSVFQYFVRSVVKCIPFLPIILLFNDKRKAAHDLIAGTIVVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT30</accession>
    <name>D7VT30_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conjugative transposon TraN protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">traN</name>
        <name evidence="2" type="ORF">HMPREF0766_14134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996001.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14134"/>
    <dbReference type="EnsemblBacteria" id="EFK56931">
        <property type="protein sequence ID" value="EFK56931"/>
        <property type="gene ID" value="HMPREF0766_14134"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3504">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059718_0_0_10"/>
    <dbReference type="OrthoDB" id="808821at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022298">
        <property type="entry name" value="Conjug_transposon_TraN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13595">
        <property type="entry name" value="DUF4138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03780">
        <property type="entry name" value="Bac_Flav_CT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107648" evidence="1">
        <location>
            <begin position="24"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="297" mass="33959" checksum="99165645EEA5FE14" modified="2010-10-05" version="1">MKNLFKTLWAFALTIGLAVNSFAQDSIRTPLALGKIEPYKMEVTYDKTSHLIFPTAIRYVDLGSEYLIAGKAEDAENVLRVKASVRNFEPETNFSVITNDGRFYSFSVYYSSYPEATSYDLLTMQKSVDRTNGNDVLFEELGNNSPSLAGLLLETIYKKDKRIVKHIGAKSFGIQFILKGIYIHNGKYYFHTELRNKTNVPFEIDFINFKVVDKKVAKRTVVQEIPLTPLRTYKPLDGIKGKSTEQNVFLLDQFTIADDKILLIEIFEKNGGRHQTLQVENSDLIKARLIDDMHLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTE9</accession>
    <name>D7VTE9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996301.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14253"/>
    <dbReference type="EnsemblBacteria" id="EFK57050">
        <property type="protein sequence ID" value="EFK57050"/>
        <property type="gene ID" value="HMPREF0766_14253"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1481129_0_0_10"/>
    <dbReference type="OrthoDB" id="1907062at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107279" evidence="1">
        <location>
            <begin position="25"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="182" mass="19776" checksum="7944842FE4592E20" modified="2010-10-05" version="1">MKNKIFFLLSVVFAVALSVGCSKSDNKPDNGNQDVFMRCKFNGKLREFAFHVNANDPPSEKLIHFVVVSGWEGEDMARSPGFGFSLVLPEGAQEKTYEVAGGLTPELDATYFVQNYNGSTNIGTSTWSGGRTEGTSFKLTITSLSDWGVKGKFSGLLKGDDNSLITVTDGEFSAPYNYGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTP1</accession>
    <name>D7VTP1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TonB-dependent siderophore receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0766_14361</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001688.1">
        <property type="nucleotide sequence ID" value="NZ_GL379777.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14361"/>
    <dbReference type="EnsemblBacteria" id="EFK55800">
        <property type="protein sequence ID" value="EFK55800"/>
        <property type="gene ID" value="HMPREF0766_14361"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_9_4_10"/>
    <dbReference type="OrthoDB" id="169533at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="121"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="337"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK55800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="788" mass="88849" checksum="AC8B3211FD8486AD" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTY8</accession>
    <name>D7VTY8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK55767">
        <property type="protein sequence ID" value="EFK55767"/>
        <property type="gene ID" value="HMPREF0766_14458"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3205430_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="45" mass="5437" checksum="3E7CD041B72DB3AF" modified="2010-10-05" version="1">MQEGRFQQLDKLTEKYKNVFFLYSRSLLLNSKLQAFLKQTKPLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VG85</accession>
    <name>D7VG85_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001818.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10004"/>
    <dbReference type="EnsemblBacteria" id="EFK60060">
        <property type="protein sequence ID" value="EFK60060"/>
        <property type="gene ID" value="HMPREF0766_10004"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066193_1_1_10"/>
    <dbReference type="OrthoDB" id="1757088at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="199"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="270" mass="30576" checksum="CA2DD96B87BDA5E7" modified="2010-10-05" version="1">MPINFLTAIRAQNKENYIQIPLENGSGSSIEGIYDFDGSMLCEQVALFSDGYPALILMPSCSDTVTVKSTTTQITLGSAWMCGGLIQRNFLQSAKPEGTIRIVRFHAPAFFRLFDLQPDCFASQSVYDLTNSSEPFFRSFINTYYQATDAKSRIKAVVNFISGQHIPSTKIPALLQERLEEIGKSSSPTIQHINYKWWQRAFKKHLGIAPQQYIQIQRFLKAYTLLEAFPSLSLNDVAYKIGYYDSNHLLKDFNKYIGQSPKAYFKTGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGC8</accession>
    <name>D7VGC8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_10047</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10047"/>
    <dbReference type="EnsemblBacteria" id="EFK60103">
        <property type="protein sequence ID" value="EFK60103"/>
        <property type="gene ID" value="HMPREF0766_10047"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_2_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="152"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="489"/>
            <end position="1116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK60103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1118" mass="122735" checksum="FB33F8F23DE0B8B9" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGG3</accession>
    <name>D7VGG3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002022.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK60138">
        <property type="protein sequence ID" value="EFK60138"/>
        <property type="gene ID" value="HMPREF0766_10082"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2156754_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="111" mass="11908" checksum="BB95D0CB0D775962" modified="2010-10-05" version="1">MKNKIIIVLVPIILAALISAYLTFEGSFINAVLSPLTGCGALLGLLNLGLTKISKLVCIILNTILGILIFALLYFVKAEYILQYLLIGGIIGLLTGIINSLLISRPQKNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGI6</accession>
    <name>D7VGI6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nagZ4</name>
        <name evidence="7" type="ORF">HMPREF0766_10105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10105"/>
    <dbReference type="EnsemblBacteria" id="EFK60161">
        <property type="protein sequence ID" value="EFK60161"/>
        <property type="gene ID" value="HMPREF0766_10105"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007082_5_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20b" evidence="6">
        <location>
            <begin position="6"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="5">
        <location>
            <begin position="117"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK60161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="502" mass="57517" checksum="1395D7827821F52F" modified="2010-10-05" version="1">MIIGSGLLKLQQSANIWSSDTHFDDAVQYLQQEVLKNKSATWFRGDDSSKALIHFVSDTKVSEEGYVIRVVKDKVEILASTGKGALYGAVSLLQMILTSSSGTMELPYCEIKDQPAYGWRGFMLDESRHFFGKQKVKSLLDWMAFYKLNKFHWHLTDEPAWRLEILRYPLLTLVGGVGSFTNATAAAQYYQQADIEEIVRYAADRNIEVIPEIDMPGHATAANRAYPQYSGGGNDKHPDFTFHPGKEGTYGYLTHILKEANVLFPSGMLHLGGDEVSFGSEAWNNDAQIKELKAKYQLADNKQVETYFMRRMADSVYSMGAKVLAWDEMADAGLPKDKTILMWWRHDKQDQLKTVLQNGYSTILCPRLPLYFDFVQEENHRYGRKWGKGFNALSDVYHFRPSKYDSLAVRKDQILGIQANLWTETVTNTNRLDYLIFPRLAAMAEVAWSTDKVKSFDRFCDYLPAHLKLYRAADLYYFDPFNKTNPEPVVYKTQRAYIDNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGK8</accession>
    <name>D7VGK8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase, S9A/B/C family, catalytic domain protein</fullName>
            <ecNumber evidence="5">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_10127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996651.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10127"/>
    <dbReference type="MEROPS" id="S09.075"/>
    <dbReference type="EnsemblBacteria" id="EFK59210">
        <property type="protein sequence ID" value="EFK59210"/>
        <property type="gene ID" value="HMPREF0766_10127"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_0_2_10"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107438" evidence="3">
        <location>
            <begin position="20"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="4">
        <location>
            <begin position="491"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="699" mass="78687" checksum="7E4118774703049D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGM7</accession>
    <name>D7VGM7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996718.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10146"/>
    <dbReference type="EnsemblBacteria" id="EFK59229">
        <property type="protein sequence ID" value="EFK59229"/>
        <property type="gene ID" value="HMPREF0766_10146"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032RN1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177544_0_0_10"/>
    <dbReference type="OrthoDB" id="1989621at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021527">
        <property type="entry name" value="DUF2795"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11387">
        <property type="entry name" value="DUF2795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="73" mass="8614" checksum="16A6E17DF402C943" modified="2010-10-05" version="1">MYWTLELASHLEDAPWPATKDELIDYAIRSGAPVEVIENLQALEDDGEPYENIEEIWPDYPTKDDFFFNEDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGN1</accession>
    <name>D7VGN1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="11">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">trpB</name>
        <name evidence="13" type="ORF">HMPREF0766_10150</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TrpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="11"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996730.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10150"/>
    <dbReference type="EnsemblBacteria" id="EFK59233">
        <property type="protein sequence ID" value="EFK59233"/>
        <property type="gene ID" value="HMPREF0766_10150"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_3_1_10"/>
    <dbReference type="OrthoDB" id="912282at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="56"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFK59233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="394" mass="43211" checksum="AB73349D2A080D2E" modified="2010-10-05" version="1">MSKYQVNEKGYYGPFGGAYIPEMLYPNVEELRQQYLSIIKEKSFQEEFQSLLRDYVGRPSPLYLAKRLSEKYGANIYLKREDLNHTGAHKINNTIGQILLAERLGKKRIIAETGAGQHGVATATVCALKGLECVVYMGEVDIERQAPNVARMKMMGAQVVAAKSGSRTLKDATNEALRDWINNPVDTHYIIGSVVGPHPYPDMVAKFQSIISEETKRQLKEKTGKSNPDYVLACVGGGSNAAGMFYHYVDEEDVKIIAVEAAGHGVDSGETAATTVLGKEGVLHGSRSILMQTEDGQVIEPYSISAGLDYPGIGPQHAWLFKSGRGQYVSATDEEAMQAGLQLTRLEGIIPAIESSHALAHLEKMNFDGSETVVVCLSGRGDKDLDNYMKYFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGP9</accession>
    <name>D7VGP9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996780.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10168"/>
    <dbReference type="EnsemblBacteria" id="EFK59251">
        <property type="protein sequence ID" value="EFK59251"/>
        <property type="gene ID" value="HMPREF0766_10168"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085002_2_0_10"/>
    <dbReference type="OrthoDB" id="1226328at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021958">
        <property type="entry name" value="DUF3575"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12099">
        <property type="entry name" value="DUF3575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107167" evidence="1">
        <location>
            <begin position="23"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="203" mass="22638" checksum="57ACCADF767B0454" modified="2010-10-05" version="1">MKAKVVLLILFSLITNCNTLFAQFSRSRYNSSSSGWVFKTNVAGLAIGNINAAAETVVNANYDFPMTVHTSVSYNSLKKYAGNTKLRHIALQPEFRMWMQGEAFNGFFAGANLNYAFYNVGYISLSNSLKDNYYQGQLFGIGIAGGYQMTISDKIGAEASLGVGYANMNHDVYKKEKNSGKLRSERYNYFGPNKFSISFVYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGQ8</accession>
    <name>D7VGQ8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK59260">
        <property type="protein sequence ID" value="EFK59260"/>
        <property type="gene ID" value="HMPREF0766_10177"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_908837_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="306" mass="33248" checksum="2B7F48F0F88F014F" modified="2010-10-05" version="1">MLPVLRNHRYAIDITKVHAAGFSDQATAWASKPVGMTASVTVWNEIPVSEGNVPLQYLKLAATKVGLLGLQGQTTFTIWTNAPETAVQLVLPSWLVNLGYDKVGDKITYLLHVNENSSTTTVRSATISVQVGRLTAKLEAKQGVKPIDLGPGYGFYIVRDDLTLAGYWDQIANVPYNLVSPLDASLTQKDPPNPKSCVALFGPGARLPTMYELRQLLPTNHNERMAVNAAIQAKGGVPMMYNQTSGAASPSNPYISSTSASWLSSDYTDVSFVTIRSDLGAVYATDRKFTNQGFMNNRARCVMSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGX2</accession>
    <name>D7VGX2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996965.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10241"/>
    <dbReference type="EnsemblBacteria" id="EFK59324">
        <property type="protein sequence ID" value="EFK59324"/>
        <property type="gene ID" value="HMPREF0766_10241"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50335RS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1034077_0_0_10"/>
    <dbReference type="OrthoDB" id="1702101at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106928" evidence="1">
        <location>
            <begin position="19"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="269" mass="30799" checksum="77D0F8ED82838EA6" modified="2010-10-05" version="1">MKITVLLLLAMLSISGCANQQKKQEPAYAETLPSVVDTTGTVKFNSDSLQISEIDSAAFAYLRTSGPKQHDSLFYIKDFGKVKKMLKGRVVFSGYNENADLDSTIDGEFVSSIRFKNGKLHYYKTYDSVDRINRVTDVAFVAYYPSEDILFCEGGHSSDYSFNLTTGEQGGEVGNPGYIRYNPSKSSRLNGYFPGQECDEYFIQKKTGTGFKSIFNLRDAFSFLEKENLYFCFMTDVFWHDDHTLYFKHVYFPNTEPVSKFYRIHIRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH24</accession>
    <name>D7VH24_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybaO2</name>
        <name evidence="5" type="ORF">HMPREF0766_10293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997106.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10293"/>
    <dbReference type="EnsemblBacteria" id="EFK59376">
        <property type="protein sequence ID" value="EFK59376"/>
        <property type="gene ID" value="HMPREF0766_10293"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_0_0_10"/>
    <dbReference type="OrthoDB" id="1844486at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="153" mass="17704" checksum="64659DB81F588A23" modified="2010-10-05" version="1">MSVLDDTDLKLLRILQKDSTLSNKELAFQLHKSIPAIHERVKKLKAQGYIKRTVAILDRHRIGMGLISFSQVFLKAHTADVLNEFEREVAKFPEVMECYQMAGSYDFMLRIATRDMDAYHQFLRHKLSVLPHVSTVQTYFVLSETKSETAYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH44</accession>
    <name>D7VH44_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase, family 43</fullName>
            <ecNumber evidence="4">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gly43G</name>
        <name evidence="4" type="ORF">HMPREF0766_10313</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10313"/>
    <dbReference type="EnsemblBacteria" id="EFK59396">
        <property type="protein sequence ID" value="EFK59396"/>
        <property type="gene ID" value="HMPREF0766_10313"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009397_4_1_10"/>
    <dbReference type="OrthoDB" id="386120at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="2">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="369" mass="41918" checksum="0D5A2AEE4F29310C" modified="2010-10-05" version="1">MKLIIMRKQKKQRIIPLLPFVAISFCLPLSIYAQEKQAKFENSISKPLVSDMFTADPSAHVFNNKIYIYGSHDIETSVAENGSGDHFQMKDYHVLSMDSPTEKVTDHGIALAVENIPWAGKQLWAPDAAYHKNTYYLYFPLKDKEGIFRIGVATSRRPEGPFKAEKEPIKGSYSIDPAVFKDSDGSFYMYFGGLYGGQLQRWKSGVFNKNASDKADGQQSEEPALTAKVAKLSADMKQLAEKPKDVVVLDEKGNTILSGDHDRRFFEGSWVHKYNGKYYFSYSTGDTHKLVYATGDSPYGPFTYQGVILLPVIGWTTHHSIIEFQNKWWLYYHDTELSEGKTHLRNIKVTELIYNKDGSIKTIDPYGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH81</accession>
    <name>D7VH81_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ser/Thr phosphatase family protein</fullName>
            <ecNumber evidence="10">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">lpxH</name>
        <name evidence="10" type="ORF">HMPREF0766_10350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="10"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997225.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10350"/>
    <dbReference type="EnsemblBacteria" id="EFK59433">
        <property type="protein sequence ID" value="EFK59433"/>
        <property type="gene ID" value="HMPREF0766_10350"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2908">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074586_1_0_10"/>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043461">
        <property type="entry name" value="LpxH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010138">
        <property type="entry name" value="UDP-diacylglucosamine_Hdrlase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34990">
        <property type="entry name" value="PTHR34990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34990:SF1">
        <property type="entry name" value="PTHR34990:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="9">
        <location>
            <begin position="6"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK59433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="254" mass="29960" checksum="6C7E49C67950DB79" modified="2010-10-05" version="1">MSDRKNIYFASDFHLGSYPEEKSIAREHEIVNWLNHIKSDAKELYLMGDVFDFWFEYRSVVPKGYIRFLGKLAELADQGVKITFFKGNHDMWMFGYLRDQLGANIIDNELEIIRDGKSFYLHHGDGLGDGDKKYKILKKIFRSKACQWLFARLHPNLGIGIAQRWSRSSRAANDIDEIFLGEDKEWLIQYARQLENTQHFDFYIFGHRHLSYYLPLSSQSQIINLGEWFKGKSYAVWNGTTLELLQWNNELKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHA7</accession>
    <name>D7VHA7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10376"/>
    <dbReference type="EnsemblBacteria" id="EFK59459">
        <property type="protein sequence ID" value="EFK59459"/>
        <property type="gene ID" value="HMPREF0766_10376"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064922_0_0_10"/>
    <dbReference type="OrthoDB" id="1054816at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036781">
        <property type="entry name" value="Smr_assoc-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158949">
        <property type="entry name" value="SSF158949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="225" mass="25482" checksum="A0ADEE58A76D4BC6" modified="2010-10-05" version="1">MTIEKTNDIHMKFKIGDLVRFVDEPIEGHVTSFQDNDIVGVTDETGFEIPVLTSKITLVHGNMNREDDEVTETKITEPAKFVEKGILLAVSGDQKEGLAKLHIINETSYELLVSVSEINNAKAKGIFAGQVSPHDVVQFFSGNFSAVGNWPNFHFQIIKHSRSAQKINQPIEKEQRVRPVDLTNAKQMNDTLCEKVWHYVLDKEEENIGLDKLQSHFISNRPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHB3</accession>
    <name>D7VHB3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="7">GSA</shortName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="7">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">hemL</name>
        <name evidence="9" type="ORF">HMPREF0766_10382</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997294.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10382"/>
    <dbReference type="EnsemblBacteria" id="EFK59465">
        <property type="protein sequence ID" value="EFK59465"/>
        <property type="gene ID" value="HMPREF0766_10382"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_1_5_10"/>
    <dbReference type="OrthoDB" id="493793at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK59465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="438" mass="47631" checksum="78ED1EB4650ED042" modified="2010-10-05" version="1">MSNTSYPDISRAKSAELFEKAKQYFPGGVNSPVRAFKSVYGTPLFIERGDKAHIWDADGNEFVDFCCSWGPLILGHNNAQVREAVTAQLGKGLSFGAPTALENELAELILSNNKYLEKIRFVSSGTEAVMSAIRLARGYTKRDKIVKFEGCYHGHSDSLLVKAGSGLVTFGETSSAGVPKSFADETIVIALNDEKALQTVFEQFKDQIAAVIIEGIPANNGLLIQTKAYINFLRQITKDNGALLIFDEVITGFRLGFEGAAAYYDIQPDIITYGKIIGGGMPVGAYGASKELMSCISPDGNVYQAGTLSGNPVAMSAGIAALNILAQPDFYTSLAATTATFVQAIQEYTEQHGYELNIPTIGSIFWFAFTTNTEIRRADQIDPASMEKYKVMHRELLNRGIYMGPSGYEVGFISAAHTEEDLEKAKKAIFESLDIVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHE3</accession>
    <name>D7VHE3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997374.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10412"/>
    <dbReference type="EnsemblBacteria" id="EFK59495">
        <property type="protein sequence ID" value="EFK59495"/>
        <property type="gene ID" value="HMPREF0766_10412"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007177_0_0_10"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="696"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="751"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="917"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="1011"/>
            <end position="1225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1231" mass="141971" checksum="1F23374C4C6E6C9E" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHE5</accession>
    <name>D7VHE5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipocalin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997379.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10414"/>
    <dbReference type="EnsemblBacteria" id="EFK59497">
        <property type="protein sequence ID" value="EFK59497"/>
        <property type="gene ID" value="HMPREF0766_10414"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50311W3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123905_0_0_10"/>
    <dbReference type="OrthoDB" id="1338691at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024311">
        <property type="entry name" value="Lipocalin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13648">
        <property type="entry name" value="Lipocalin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107117" description="Lipocalin-like domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin-like" evidence="3">
        <location>
            <begin position="55"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="188" mass="20425" checksum="C7214D3EF0F06049" modified="2010-10-05" version="1">MRKHILTFVAILAGVFLFSSCGAQRKTTSSSGSSNSSSTEVNDGPSASEWKGGVKGTWILNTITRENIPAAYTIKTVFEEAPAECFEGSVWNFPSNGKGSIEFTAEGTLCAKGAVRNIVWSIYNPGKMGGQPQFQFKKIYSGDKARNVTTGYRMDLSFSDGEKLVMKMPVDLDNGTGYLVFNFSKAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHU4</accession>
    <name>D7VHU4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10563"/>
    <dbReference type="EnsemblBacteria" id="EFK59646">
        <property type="protein sequence ID" value="EFK59646"/>
        <property type="gene ID" value="HMPREF0766_10563"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1142017_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="243" mass="27212" checksum="7746CEC27C311AC9" modified="2010-10-05" version="1">MKKSTQIIMLIISFGIFCYTIFEVWQIYRFQQYEMLGGVKNIPPSYLSAFRPDISNFSNGSTVIRKSRTTISSFVYDNKYGIFIYSLDLLEDNPLNKIVKIGKPVNEVGNSPNIFYSGVSNSGIGSFVVFNYALSEPSKAINGLDVIIEKDKIIDLIVENDSIICYHFPNSSGFKLKYVGDSYSDVVFKTEPNQNINFNGKANIGLIIKKQNKKLVIAAVSKIDVDPELSENVLLDLVNGNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHV9</accession>
    <name>D7VHV9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10578"/>
    <dbReference type="EnsemblBacteria" id="EFK59661">
        <property type="protein sequence ID" value="EFK59661"/>
        <property type="gene ID" value="HMPREF0766_10578"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032Y49">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1040885_0_0_10"/>
    <dbReference type="OrthoDB" id="1813026at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107499" evidence="1">
        <location>
            <begin position="26"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="276" mass="31848" checksum="D427AA3F67A7E107" modified="2010-10-05" version="1">MNKKRLLCIVSALTFVLLTSCISRLSRPEITGKVMDYDNNPIPDCNVGEVVTDSLGNFILPERRYNAFLLTEMFYMEAPPLRVGEVIEKAGYESDAIEMFSTFGGGRSKGAKMEIGNIYLRKKDEKINIPKILQGEWLLSANKQLDTLYLVHSKLRESYTTSKFQNFYSLYEQYTDNYLRSFGPDSLPEGIIRKFNYLDFHNDRKIRLTKIIQYGHKDGRSTIGEKNSPNDTLQFSGTWNIVNDTTLRFITDDKELNSTYQILQSDLSFFQLKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VHZ4</accession>
    <name>D7VHZ4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997857.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK59696">
        <property type="protein sequence ID" value="EFK59696"/>
        <property type="gene ID" value="HMPREF0766_10613"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033ZJ3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1936759_0_0_10"/>
    <dbReference type="OrthoDB" id="1893476at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="129" mass="14437" checksum="AA6EAFAEF0F71959" modified="2010-10-05" version="1">MTNIKERILEIAKFKKINKADFFKDLGLSYANFKGVQKNSSLGSDTLVTILAKYSDINEAWLLKGTGEMFKDGIGVALDDPDGYVSMRHIDSTIEALNKVVETQEITIRSQLKTIAALEAQLKQLQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIB9</accession>
    <name>D7VIB9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome C biogenesis protein transmembrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10738</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998106.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10738"/>
    <dbReference type="EnsemblBacteria" id="EFK59821">
        <property type="protein sequence ID" value="EFK59821"/>
        <property type="gene ID" value="HMPREF0766_10738"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015841_0_0_10"/>
    <dbReference type="OrthoDB" id="1055204at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107172" evidence="2">
        <location>
            <begin position="22"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="3">
        <location>
            <begin position="89"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="558" mass="61107" checksum="6BC698D6A514BA80" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIG8</accession>
    <name>D7VIG8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4142 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998203.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10787"/>
    <dbReference type="EnsemblBacteria" id="EFK59870">
        <property type="protein sequence ID" value="EFK59870"/>
        <property type="gene ID" value="HMPREF0766_10787"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1389446_0_0_10"/>
    <dbReference type="OrthoDB" id="2137842at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025419">
        <property type="entry name" value="DUF4142"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13628">
        <property type="entry name" value="DUF4142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4142" evidence="1">
        <location>
            <begin position="50"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="196" mass="22104" checksum="3325DFF87F02366C" modified="2010-10-05" version="1">MKAYLYYTLLSAIAFGLSSCQKPTSIKNAPLTDSVVSASILDYNIYFDAERFFIKTVESGLKLKNASEQALQMASSDSIRNLALALKECHTKDVAQIIALGDNMNVAIPEVMNVIDAQQVSDLKEEKNRDFDYRFIKMVIEDYERSIPLFEQAVSDANNSEIRNVASSVLPNLYAQLSKARIIERVYFRDKLISKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIQ7</accession>
    <name>D7VIQ7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase, NUDIX family</fullName>
            <ecNumber evidence="3">3.6.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nudF</name>
        <name evidence="3" type="ORF">HMPREF0766_10876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.13" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998383.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10876"/>
    <dbReference type="EnsemblBacteria" id="EFK59959">
        <property type="protein sequence ID" value="EFK59959"/>
        <property type="gene ID" value="HMPREF0766_10876"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_8_0_10"/>
    <dbReference type="OrthoDB" id="1831818at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="180" mass="20715" checksum="032B9F4260E38FF8" modified="2010-10-05" version="1">MEKWKLLASEYIIKRPWATLRVDKMELPNGNIKEEYYVLEYPTWVNMIGITKDQKILFVRQYRHGADQIMVELPAGVVEEGEDPRDAAKRELLEETGFAFEGIEEICKLYANPATSGNLTYTYILQGGVKVQEQELDNSEDIEVVEMTIEEAKTFLFENKLGQALHTAALFYAFRKLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIR8</accession>
    <name>D7VIR8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_10887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10887"/>
    <dbReference type="EnsemblBacteria" id="EFK59970">
        <property type="protein sequence ID" value="EFK59970"/>
        <property type="gene ID" value="HMPREF0766_10887"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_210795_2_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025379">
        <property type="entry name" value="DUF4295"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14128">
        <property type="entry name" value="DUF4295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK59970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="53" mass="5601" checksum="E4E2B239C69F7BB2" modified="2010-10-05" version="1">MAKKAVASLQKGGGKEFTKVIITTRSAKTGAYTFKSSMIHNDKVKDALAAATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIX0</accession>
    <name>D7VIX0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, ATP-binding protein</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_10939</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998515.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10939"/>
    <dbReference type="EnsemblBacteria" id="EFK60022">
        <property type="protein sequence ID" value="EFK60022"/>
        <property type="gene ID" value="HMPREF0766_10939"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_10"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="314"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="554"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="346"/>
            <end position="353"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK60022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="620" mass="70742" checksum="4AD954ADDE7A5789" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIZ4</accession>
    <name>D7VIZ4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998558.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10963"/>
    <dbReference type="EnsemblBacteria" id="EFK60046">
        <property type="protein sequence ID" value="EFK60046"/>
        <property type="gene ID" value="HMPREF0766_10963"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057100_0_0_10"/>
    <dbReference type="OrthoDB" id="503666at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021428">
        <property type="entry name" value="DUF3078"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11276">
        <property type="entry name" value="DUF3078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107283" evidence="1">
        <location>
            <begin position="29"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="354" mass="40483" checksum="06727B8756B3255B" modified="2010-10-05" version="1">MFNKTAIMKIKNYAFLLLMGLLFKTAHAQVDLKDLRAKPDSITNNQDKQKLNIKPINVPIPKLALEVDYWKHWSRFGVNANQAAFSDSWKGGGVNSLALGLNAWHKSEFNKDDFNFITEVDLRYGKVKNKDQMAKKNNDRIFWDNKLSYKLSKSWSLFTSLTFESQFDVGYTYETKDGVERIKETVSAFMAPGYVTESFGLEYKPDNTFSVRLGTGTARQTFVLDDRIKPLTIEQYAIKYPGQTITKDQEKYGVKAGKTFKNDLAFQITANLDKNLSKNLNLKSRYNLFANYEKIGDPSHRLDVWLTAKITRLVNVNLNGIMLYDSDDVTPENPKAKLQFSESLALGLTFNLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ17</accession>
    <name>D7VJ17_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002107.1">
        <property type="nucleotide sequence ID" value="NZ_GL379779.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10986"/>
    <dbReference type="EnsemblBacteria" id="EFK59152">
        <property type="protein sequence ID" value="EFK59152"/>
        <property type="gene ID" value="HMPREF0766_10986"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047118_0_0_10"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="213"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="426" mass="48799" checksum="D8F55599E9791DBB" modified="2010-10-05" version="1">MTHTFFTPLKQFLHKLIHVGIYPDMPYVESRYTKLLNVLNWLGLCFMLGYAILNLTNGRYFLTALNMFNMLDATAVLILHRLRMYLSARLVMVGCRIVIYTISGLYFHNGAEYFLLTLLITTIIIFDSRWIRTFLCSLIILACISVVLFPQPPLLGVPVMEEQIIVNIVVAIGLIIGTVTFFKSIQYGYQREVEKQRQALIELNRDKQRMFSILAHDIRSPMATLENLLQIFYENLLTRTEQMKTTQLLKDQVIQLGTTMDDLLNWSARGMQGMETVKTSFLLYPLIKELFQFFDLIIKQKQLEVEMYIDKELILSADRDQIAVVMRNLLSNACKFSHRGGRIRIVAIEKNNSIEVCIEDEGVGMDENRINRLFTSSNSSVRGTAGEKGYGLGLMLCAEFVRLNEGNIVVKSRLGEGSIFTVILPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ25</accession>
    <name>D7VJ25_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_10994</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000003">
        <property type="protein sequence ID" value="EFK59160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002123.1">
        <property type="nucleotide sequence ID" value="NZ_GL379779.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10994"/>
    <dbReference type="EnsemblBacteria" id="EFK59160">
        <property type="protein sequence ID" value="EFK59160"/>
        <property type="gene ID" value="HMPREF0766_10994"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_10"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="135"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="135"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK59160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="230" mass="26243" checksum="D7496E44C6CFC3BA" modified="2010-10-05" version="1">MSSAKQKILVVDDEQDIVELIAYNLKREGYQVFTASNGKEAIAQAKEVNPDLIILDVMMPQMDGIEACRLMRAMPEFKHTFMVFLTARSEEYSEIAGFHVGADDYIAKPIKPRALMSRINAILRRNTAEDEIHEGNRLEVSDLVIDRDSFLAYRGADKITLAKKEFELLYLLASKPNKVFTREQILKSIWEDSVVVTNRTIDVHIRKLREKIGENYVATVKGVGYKFELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ62</accession>
    <name>D7VJ62_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase (NAD) family protein</fullName>
            <ecNumber evidence="6">1.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">aldA</name>
        <name evidence="6" type="ORF">HMPREF0766_11031</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK58915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11031"/>
    <dbReference type="EnsemblBacteria" id="EFK58915">
        <property type="protein sequence ID" value="EFK58915"/>
        <property type="gene ID" value="HMPREF0766_11031"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_2_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="40"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="515" mass="56600" checksum="988FE34F52D9DD95" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJI3</accession>
    <name>D7VJI3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter, major facilitator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tetA</name>
        <name evidence="8" type="ORF">HMPREF0766_11152</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000660.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11152"/>
    <dbReference type="EnsemblBacteria" id="EFK59036">
        <property type="protein sequence ID" value="EFK59036"/>
        <property type="gene ID" value="HMPREF0766_11152"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_10_11_10"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="8"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="409" mass="44432" checksum="FD1ED57D1C769FDB" modified="2010-10-05" version="1">MQVQKKSGLLFIFITVAIDVIGLGIIIPVLPTLIKELTGGTLSEASEYGGWLMFSYAITQFVFASVLGNLSDRFGRRPVLLLSLLGFCINYLLMGFATSILWLFIGRFVAGITGASMTVAAAYTADISTPDKKAQNFGLLSAAFGIGFIIGPVLGGLLGHYGPRVPFFAAGAISFINFVYGYFMVPESLKPENRRPFQWKNANPVGAFRYIAKYPQIKPLIVCIFLINVAAHAVQSTWSYYTMERYAWNERMVGISMGFIGVLLAIVQAGLLRIIIPKLGLPKSIVIGLSLYVISFPLMAFSSEPWMLFAASVPFVFAGIAGPAMQSFISNHTPNNEQGQIQGGITSIVSLTAIFGPPLMSNIFAFFTNHKHSAYFPGAPFMMASVLSLIAVSIAALYFNKKEEPATES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJM0</accession>
    <name>D7VJM0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FG-GAP repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yesX</name>
        <name evidence="3" type="ORF">HMPREF0766_11189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000735.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11189"/>
    <dbReference type="EnsemblBacteria" id="EFK59073">
        <property type="protein sequence ID" value="EFK59073"/>
        <property type="gene ID" value="HMPREF0766_11189"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002616_2_0_10"/>
    <dbReference type="OrthoDB" id="149095at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10318">
        <property type="entry name" value="RGL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041624">
        <property type="entry name" value="RGI_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034641">
        <property type="entry name" value="RGL11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43118">
        <property type="entry name" value="PTHR43118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18370">
        <property type="entry name" value="RGI_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107297" evidence="1">
        <location>
            <begin position="22"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="RGI_lyase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="615" mass="68556" checksum="F18C4084A7BD7706" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJM4</accession>
    <name>D7VJM4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polygalacturonase (Pectinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11193</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11193"/>
    <dbReference type="EnsemblBacteria" id="EFK59077">
        <property type="protein sequence ID" value="EFK59077"/>
        <property type="gene ID" value="HMPREF0766_11193"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016031_8_3_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="Pectate_lyase_SF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pectate_lyase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107580" evidence="5">
        <location>
            <begin position="32"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate_lyase_3" evidence="6">
        <location>
            <begin position="56"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="481" mass="53206" checksum="D3E79D30684F36BB" modified="2010-10-05" version="1">MNVFKCNPRVLAPKAMLMGILLVFVSFTAFATSDPGWVDKVGARNFKVGKAVVYANDFGAREDGKTISTKAIQQAIDACAKKGGGKVQFRPGKYLTGSVFIKSGVFLHVDEGVELLGSQSLEDYPQINTRVAGIEMIWPAALVNINGQQKAGISGKGIINGQGKPFWDAYWKLRSEYDKKGLRWIVDYDAQRPRTVIVDGSEDIIIRDVTLKQAGFWTVHLLYSSYVTVDGIIIKNNINGIGPSTDGIDIDSSKWIRIQNADIDCNDDNFCIKSGRDWDGLRVNRPTEYVLITDCISRKGDGLITFGSETSGGMRHIIARNLKAHGTKVGIRLKSARNRGGVVEDILLENIQMDSVRTAFEVTPNWNPSYSYSKLPAGYDINKVPEHWKKMVTPVEPASKGIPTFQNIQIKNVFVKFAQRAINVDGLQENPLQKFSLENVAITAKTAGVIRHAKNWQLKNVKVTAQDGTKVVLEDTENINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJQ0</accession>
    <name>D7VJQ0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000810.1">
        <property type="nucleotide sequence ID" value="NZ_GL379774.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11219"/>
    <dbReference type="EnsemblBacteria" id="EFK59103">
        <property type="protein sequence ID" value="EFK59103"/>
        <property type="gene ID" value="HMPREF0766_11219"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107963_1_0_10"/>
    <dbReference type="OrthoDB" id="1533499at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021314">
        <property type="entry name" value="DUF2911"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11138">
        <property type="entry name" value="DUF2911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107027" evidence="1">
        <location>
            <begin position="20"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="172" mass="18903" checksum="CA9F1BCF1352734F" modified="2010-10-05" version="1">MKTQAILLFFVLLSATAFGQTDKSKRPSPPDSVRITTDDGVTIAVNYSRPSLKGRQIGVDVAPIGKVWRTGANEATTFEINKDVSIEGQELPAGKYSLYSIPGEQQITLIFNKTWNQWGTKYEQSEDALRVDVTPTAADTAQEQFKISADKSGKVQLIWGEHAVPFTVKAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJS6</accession>
    <name>D7VJS6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11245"/>
    <dbReference type="EnsemblBacteria" id="EFK59129">
        <property type="protein sequence ID" value="EFK59129"/>
        <property type="gene ID" value="HMPREF0766_11245"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009942_1_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="76"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="551" mass="61963" checksum="CF37DC09837FA7EB" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJU7</accession>
    <name>D7VJU7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11266"/>
    <dbReference type="EnsemblBacteria" id="EFK58549">
        <property type="protein sequence ID" value="EFK58549"/>
        <property type="gene ID" value="HMPREF0766_11266"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2540858_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="83" mass="9255" checksum="0F7CC2D73BFA278F" modified="2010-10-05" version="1">MDICRFKVVEMDRSGCSGCLGTYKLKAKGLLHRALETIGLGAAVGRVVQYAGWVITITGVSYELGKHYGLSKWYGKHDTKWFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKA4</accession>
    <name>D7VKA4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chorismate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.151</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Menaquinone biosynthetic enzyme MqnA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mqnA</name>
        <name evidence="4" type="ORF">HMPREF0766_11423</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>chorismate = 3-[(1-carboxyvinyl)-oxy]benzoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:40051"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:76981"/>
            <dbReference type="EC" id="4.2.1.151"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MqnA/MqnD family. MqnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.151" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999071.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11423"/>
    <dbReference type="EnsemblBacteria" id="EFK58706">
        <property type="protein sequence ID" value="EFK58706"/>
        <property type="gene ID" value="HMPREF0766_11423"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059898_0_0_10"/>
    <dbReference type="OrthoDB" id="1062841at2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00995">
        <property type="entry name" value="MqnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003773">
        <property type="entry name" value="Menaquinone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030868">
        <property type="entry name" value="MqnA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37690">
        <property type="entry name" value="PTHR37690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02621">
        <property type="entry name" value="VitK2_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="239" mass="27143" checksum="55EA49DD9C0BF64E" modified="2010-10-05" version="1">MNKIRISAVSYTNTLPFLNGINHSDIKNKIDLRVDHPSACAQRVIDNEVDMGIIPTAALLSLPEYYINTDFCIGTEGAVDSVFIFSQKPADQISSILLDPQSRTSNGLARILLKYHWKRDVEILTEGEADAYVLIGDRTFGKKGTVPYVYDMGLEWKNFTGLPFAFALWVSNKKLPESFVEEFNEALKYGVEHAEDVIAGLPVYEGMDYRQYLTQNLDFHLTDAKREAVDRYLELYRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKE9</accession>
    <name>D7VKE9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <ecNumber evidence="5">3.1.6.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_11468</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999196.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11468"/>
    <dbReference type="EnsemblBacteria" id="EFK58751">
        <property type="protein sequence ID" value="EFK58751"/>
        <property type="gene ID" value="HMPREF0766_11468"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_10_4_10"/>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="27"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="466" mass="52554" checksum="3D50649F7270B082" modified="2010-10-05" version="1">MGTLNQIVFLFTLFMLTTGSVSAQQRPNIILILSDDGGYEDFGCYGSQDIPTPHIDALAKGGVRFTNSYVTASVCAPSRAGLLMGQYQQRSGFEHNVSDLPADGYQMQDIGLSDTVRTIADQMQSNGYETMAIGKWHQGNETKHHPLHKGFNHFFGFIGGHRSFFPIRTAIKQEEKILNDYTEVDEKDVYYLTDMFTDKAISYMRQKRDKPYFIYLSYNAVHTPVEATPQKLAQFAHLKDAQRRSYAGLMSAMDDGIGRIVEELKKTGQLENTLLIFLNDNGAATNNGADNGPLRGLKGSKWEGGIRVPMIMHWPKQLPAGKDYKGLVSSLDLVPTCVAAAQGTVRSDMQLDGVNILPFLTGKNKQEPHDFLCWRRGVAAAIRKKQWKLIQVRGESPLLFDLNWDKGETRNLAETHPQKVKELTALLQHWEQGLDNPHWTSSYGDYNQIMKHKMDVIGRKMERQYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKI0</accession>
    <name>D7VKI0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal-phosphate dependent protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_11499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ACC deaminase/D-cysteine desulfhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999283.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11499"/>
    <dbReference type="EnsemblBacteria" id="EFK58782">
        <property type="protein sequence ID" value="EFK58782"/>
        <property type="gene ID" value="HMPREF0766_11499"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048897_0_0_10"/>
    <dbReference type="OrthoDB" id="1714795at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780">
        <property type="entry name" value="PTHR43780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="6">
        <location>
            <begin position="22"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="296" mass="33607" checksum="451E9EDA4CD54263" modified="2010-10-05" version="1">MELTFNFHSPEEEIVSPLYIEKKVRIYVKRDDLIHPYISGNKWRKLQYPLRKALKQNKQILVTFGGAWSNHLLATACAGAKFGFRTHGMVRGEEVNNPVLALCRLYGMKLHFVSRDQYQDKTSLFLHYFGEQSDNTFFIDEGGYSREAAEGCAHIIEELQQDYDHICCASGTGTTVAGLQLGLEKANLKTTLHTVPVLKGGAFIRKEVENLAVDPSGIILHTDYHFGGYARTKPELLEFIRAFVSHTGIMIEPTYTGKLFFAIDDLIRKDYFKPESRILLIHTGGLTGFLGMYDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKM4</accession>
    <name>D7VKM4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-octaprenyl-4-hydroxybenzoate carboxy-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999385.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11543"/>
    <dbReference type="EnsemblBacteria" id="EFK58826">
        <property type="protein sequence ID" value="EFK58826"/>
        <property type="gene ID" value="HMPREF0766_11543"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0043">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023348_4_1_10"/>
    <dbReference type="OrthoDB" id="1012819at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="612" mass="68209" checksum="65F73100CD2F8A7D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKN0</accession>
    <name>D7VKN0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arylsulfatase</fullName>
            <ecNumber evidence="8">3.1.6.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_11549</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.-" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999397.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11549"/>
    <dbReference type="EnsemblBacteria" id="EFK58832">
        <property type="protein sequence ID" value="EFK58832"/>
        <property type="gene ID" value="HMPREF0766_11549"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014653_3_1_10"/>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012160">
        <property type="entry name" value="LtaS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005091">
        <property type="entry name" value="Mmb_sulf_HI1246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="7">
        <location>
            <begin position="274"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="645" mass="73836" checksum="8719DE7DF0D658E8" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKY5</accession>
    <name>D7VKY5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_hyd_65N_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999628.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11654"/>
    <dbReference type="EnsemblBacteria" id="EFK58258">
        <property type="protein sequence ID" value="EFK58258"/>
        <property type="gene ID" value="HMPREF0766_11654"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004617_2_2_10"/>
    <dbReference type="OrthoDB" id="179460at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016518">
        <property type="entry name" value="Alpha-L-fucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007663">
        <property type="entry name" value="UCP007663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107356" description="Glyco_hyd_65N_2 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hyd_65N_2" evidence="2">
        <location>
            <begin position="30"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="778" mass="87002" checksum="A0F394061494F23A" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL16</accession>
    <name>D7VL16_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nitroreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999717.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11685"/>
    <dbReference type="EnsemblBacteria" id="EFK58289">
        <property type="protein sequence ID" value="EFK58289"/>
        <property type="gene ID" value="HMPREF0766_11685"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_5_1_10"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02135">
        <property type="entry name" value="YdjA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026021">
        <property type="entry name" value="YdjA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="189" mass="21484" checksum="5CEC224113286DF4" modified="2010-10-05" version="1">MSNKNEVIEAIQTRRAVFQANFTDQEVSREDILTILEAANAAPTHKRTQPWRFVIFRKEGLQRLGTELSRIYKTVTPAEKYQEKTEITMGEKATSSNVAIALIVNYTGELPEWEELAATSCAIENLWLAAHSLGLGGYWASPGLINHLGEFLNLEENQKCIGIFYLGHHQAESREPIRTPITEKIRWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL17</accession>
    <name>D7VL17_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TonB family domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999719.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11686"/>
    <dbReference type="EnsemblBacteria" id="EFK58290">
        <property type="protein sequence ID" value="EFK58290"/>
        <property type="gene ID" value="HMPREF0766_11686"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049705_0_0_10"/>
    <dbReference type="OrthoDB" id="1802665at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="214" mass="24381" checksum="B7A2EE065152B6F0" modified="2010-10-05" version="1">MENNYQLSRIHNYINGLMSKDEMFQLEREALEDPFLQDAIDGYRMQNKVDIGKLSLLQQRLNKRVAEQHQEKGVRFFGWQRLSIASAAAVLFVVSLVFLWMKNYMVQKQSRTVDVELSVGEYSIQVEPIMNGGEAVPAGGWKQLDNYIHKNNPGLEVGGSVTVSFEIDEKGKPYNIRIEQADNDQIANSSKTLLEKGPKWEGKAATLRIVYPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL37</accession>
    <name>D7VL37_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11706"/>
    <dbReference type="EnsemblBacteria" id="EFK58310">
        <property type="protein sequence ID" value="EFK58310"/>
        <property type="gene ID" value="HMPREF0766_11706"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3103968_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="51" mass="5759" checksum="9956B2E8D0E4D5FD" modified="2010-10-05" version="1">MSGSKLFLLLYNNKIMSRLCNRLIAVKQNKKGGNPTFPPSKVTFIGLRLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL98</accession>
    <name>D7VL98_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exodeoxyribonuclease III</fullName>
            <ecNumber evidence="4">3.1.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">xth</name>
        <name evidence="4" type="ORF">HMPREF0766_11767</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999913.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11767"/>
    <dbReference type="EnsemblBacteria" id="EFK58371">
        <property type="protein sequence ID" value="EFK58371"/>
        <property type="gene ID" value="HMPREF0766_11767"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027539_3_1_10"/>
    <dbReference type="OrthoDB" id="1893707at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="PTHR22748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00727">
        <property type="entry name" value="AP_NUCLEASE_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="255" mass="29513" checksum="C425BE7F026881AE" modified="2010-10-05" version="1">MKIITYNVNGLRAALKKGWLDWLKSTNADVICLQEIKATPDLIPEIALLEQLGYEHYWYPAQKKGYSGTAIFTKVSPKRVEYGCGHELYDFEGRIIRADFEKFSVMSTYFPSGTTGETRQTFKYQFLDDFQQYSDRLLKDIPNLIVCGDYNICHRAIDIHNPKSNANTSGFLPEEREWMENFINSGYVDSFRHLNPEPHQYSWWSYRAGARARNLGWRIDYNMVSAPLASQIEKSYLLNDAVHSDHCPVVVEISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM16</accession>
    <name>D7VM16_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001205.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12013"/>
    <dbReference type="EnsemblBacteria" id="EFK58021">
        <property type="protein sequence ID" value="EFK58021"/>
        <property type="gene ID" value="HMPREF0766_12013"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7VP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094210_0_0_10"/>
    <dbReference type="OrthoDB" id="1342039at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024423">
        <property type="entry name" value="DUF3050"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11251">
        <property type="entry name" value="DUF3050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="255" mass="29095" checksum="252619260C23C663" modified="2010-10-05" version="1">MDRIQEVQDYIQTERDVLLKHPLYEKLNDLESLKHFTEVHVYAVWDFMSLLKALQVKLTCTQVPWFASAYPNTRYLINEIVLAEESDEYIDGSRLSHFEMYLDAMLTIGADPQAMLDFINSLRNGENIHTAIDAVKLDIRIKDFLNFTFDTIAKGGAHEIASAFTFGREDLIPGMFTSMLSNIQNNSPAVDLSKLIYYFDRHISLDGDEHGPLAMQMIAELAGEDENKWQDIKNTAKTALQKRIALWDAINDGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM54</accession>
    <name>D7VM54_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Omp85 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12051"/>
    <dbReference type="EnsemblBacteria" id="EFK58059">
        <property type="protein sequence ID" value="EFK58059"/>
        <property type="gene ID" value="HMPREF0766_12051"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046092_0_1_10"/>
    <dbReference type="OrthoDB" id="364966at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107112" description="Omp85 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Omp85" evidence="3">
        <location>
            <begin position="238"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="433" mass="48574" checksum="5CECED96C710AFB9" modified="2010-10-05" version="1">MQRAVMVFTLVLFHITYSFAQHDTTSTVRLRKDTLAGSDSLKTPPPYQDHYDISDLFRTILHPKRKPDRSKRRSPITLMPNVAYNPTIGAQGGVKAVAGKVLGNHPNTTMSVAATSASITTKGIMVFYLSHNVFTPGNTWNFQGSLAAVHMVAPDAGIGMNMNAWTTEDERVIANPDRKIFGSRYNSYIFNEKVYRQVAHGLFLGAGVSFDLRRNIEEPQLVNGPTPPSLYSEKHGFNPKKYNSNGLLFNVQYMTRDNPNRAYSGIYSDVGIRVNQTWMGSSKNAVQLVTDFRKYFSLSKKNPEHVLGFWYWGSYKLSGTLPYFDLPGTGKDTNVRTGRGYTIGYFKGISFAYSEVEYRFPITKNKFLSGVTFLNIQSASDEIGTRLFQRWEPGGGAGLRVLFNKATRTNLCLDYAFGKYGNRGFFLGLNEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VM98</accession>
    <name>D7VM98_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F5/8 type C domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001390.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12095"/>
    <dbReference type="EnsemblBacteria" id="EFK58103">
        <property type="protein sequence ID" value="EFK58103"/>
        <property type="gene ID" value="HMPREF0766_12095"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_391128_0_0_10"/>
    <dbReference type="OrthoDB" id="744760at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035423">
        <property type="entry name" value="M60-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042279">
        <property type="entry name" value="Pep_M60_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031161">
        <property type="entry name" value="Peptidase_M60_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17291">
        <property type="entry name" value="M60-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13402">
        <property type="entry name" value="Peptidase_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01276">
        <property type="entry name" value="M60-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51723">
        <property type="entry name" value="PEPTIDASE_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107702" evidence="1">
        <location>
            <begin position="23"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M60" evidence="2">
        <location>
            <begin position="101"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="665" mass="75904" checksum="2C21ED392EEC403B" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMB4</accession>
    <name>D7VMB4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TIGR02757 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001423.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12111"/>
    <dbReference type="EnsemblBacteria" id="EFK58119">
        <property type="protein sequence ID" value="EFK58119"/>
        <property type="gene ID" value="HMPREF0766_12111"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064298_0_0_10"/>
    <dbReference type="OrthoDB" id="1238363at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014127">
        <property type="entry name" value="CHP02757"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09674">
        <property type="entry name" value="DUF2400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02757">
        <property type="entry name" value="TIGR02757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="260" mass="30726" checksum="32396DE481999E19" modified="2010-10-05" version="1">MTMSDFNIKEFLDQKVEQYNQPGFIPNDPICIPHLFARKQDIEIMGFFASVLAWGQRKTIINKCRELIDRMDGAPFDFIMHHQETDLKQLLGFKHRTFNDTDLLYFISFFRYHFSVFDSLEDAFLIGQEQTKEVSVEKALNAFKAYFFSLPDFPLRTRKHISAPVQKSTVKRINMFLRWMVRRDNNGVDFGIWTRIYPKDLICPCDLHVERVARKFGLITLDKVNWKTALELTENLRMLDPMDPVKYDFALFGLGVEREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMC1</accession>
    <name>D7VMC1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12118"/>
    <dbReference type="EnsemblBacteria" id="EFK58126">
        <property type="protein sequence ID" value="EFK58126"/>
        <property type="gene ID" value="HMPREF0766_12118"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033SA0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1053391_0_0_10"/>
    <dbReference type="OrthoDB" id="1684577at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="274" mass="32311" checksum="4BFECF3D43D0E286" modified="2010-10-05" version="1">MVKKVFVNLFMYSIIDWLKFVLSVMVKYTINKVFAESFSDPIWKIEADSNTRLLAVETRDQESTLPAFHVISFTGTRLLDNFRLKTKEWTLADIQGDYLILKKLGTNTPYAAGITVLHIPSRTITQQWHQYLLIDIFKDLLKVRHHTISSGFDEYISLSTGTPLQTTDSEIQYCANHISFPLAYNGNLPHFLQSTVYEDTMWISKIRQRYLWCYHTRKEDKFDLNICISDQYREIHRCCLLEQNSKMIPQPYFQIDDQIFLMTYNKQEIVSYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VME2</accession>
    <name>D7VME2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001472.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12139"/>
    <dbReference type="EnsemblBacteria" id="EFK58147">
        <property type="protein sequence ID" value="EFK58147"/>
        <property type="gene ID" value="HMPREF0766_12139"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50331XK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121883_1_0_10"/>
    <dbReference type="OrthoDB" id="1798942at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="182" mass="20594" checksum="95DE11B7A57B0D2B" modified="2010-10-05" version="1">MNNLLYKVLMVMGCGALCLTSCSQPASKTNNGSEQYYFSLDSFFRSETARLQKENPLISKTVSKDGDEESKSIKIKNWENELSAFTSSDINKRANVGLYKVENRDCDIIYTALQPGVSVQKIIIRENHQGEVRAVQIEKITNNILYSTEENLTYTVDSAYVISKKQHIKLMGENTYHVSGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMH4</accession>
    <name>D7VMH4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyphosphate:nucleotide phosphotransferase, PPK2 family</fullName>
            <ecNumber evidence="4">2.7.4.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ppk2</name>
        <name evidence="4" type="ORF">HMPREF0766_12171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.-" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12171"/>
    <dbReference type="EnsemblBacteria" id="EFK58179">
        <property type="protein sequence ID" value="EFK58179"/>
        <property type="gene ID" value="HMPREF0766_12171"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048699_1_0_10"/>
    <dbReference type="OrthoDB" id="953793at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016898">
        <property type="entry name" value="Polyphosphate_phosphotransfera"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022300">
        <property type="entry name" value="PPK2-rel_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028756">
        <property type="entry name" value="PPK2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03709">
        <property type="entry name" value="PPK2_rel_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="3">
        <location>
            <begin position="56"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK58179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="319" mass="38023" checksum="EFF85F6C297B4FA2" modified="2010-10-05" version="1">MPETICCNGHRLWTKFNIFIGNVDIMSPKTNYSKRLQASKNFKISDHATDISEEISVDEATARLKDVRKKLSKLQDVMYAHDKYNVLVCLQGMDTAGKDSLIREVFAKFNVRGVDVQSFKTPSEKEHQHDYLWRHYIALPEKGKFGVFNRTHYENVLVTRVHPSYLLSENLPDIREEKDVTNELWEKRYEQITNFENHLIENGTILFKFFLNLSKDEQKNRLLRRLEKEKHQWKFSPGDLSERQLWDKYMEYYEEAIQHTSKKKTPWYIIPSDCKETARYLVAQIMLEVLEQYTDIKYPELSEEIQGHIKKYKNQLENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMV2</accession>
    <name>D7VMV2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="3">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">ispG</name>
        <name evidence="4" type="ORF">HMPREF0766_12322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="3">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992820.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12322"/>
    <dbReference type="EnsemblBacteria" id="EFK57249">
        <property type="protein sequence ID" value="EFK57249"/>
        <property type="gene ID" value="HMPREF0766_12322"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0821">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012689_0_0_10"/>
    <dbReference type="OrthoDB" id="665306at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017178">
        <property type="entry name" value="IspG_atypical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037336">
        <property type="entry name" value="IspG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 3" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="578"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="581"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="619"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="675" mass="74924" checksum="C5B1C35A79CAC7C7" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMV3</accession>
    <name>D7VMV3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5668 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992822.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12323"/>
    <dbReference type="EnsemblBacteria" id="EFK57250">
        <property type="protein sequence ID" value="EFK57250"/>
        <property type="gene ID" value="HMPREF0766_12323"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031P6Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073800_0_0_10"/>
    <dbReference type="OrthoDB" id="1687355at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043726">
        <property type="entry name" value="DUF5668"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18917">
        <property type="entry name" value="DUF5668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5668" evidence="2">
        <location>
            <begin position="6"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="315" mass="34232" checksum="4EEE3D1709D36504" modified="2010-10-05" version="1">MNNKRITSGLIFLFVGIILLLDVLDIIEFNWLEIIRYWPLLIILGGINMLMPNGQSGQIAKLGFTCLLLGFLVFIGFTTPNESLISRFFKGSNIHISTDEVDDSIPSSSSKSLAIQLPKNLSVAKANFDIGTTNLKLSSQPSSLLFEAGNSSDSYFLKLTSDSAEDGTATVDLTGKKRKKGRSKNNTTLFKLNKDVVWDLNFDIGASDVQMDLSPFKIRNINFDTGASSVNMKLGRPVETSTINIDAGASSVEIRIPKDVPCQVTSDSGLSSIELSSGFVRKGDGVSETANYAQATSKYNIVIDAGVTSFKIIQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMW1</accession>
    <name>D7VMW1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RND transporter, HAE1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yegN</name>
        <name evidence="2" type="ORF">HMPREF0766_12331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992836.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12331"/>
    <dbReference type="EnsemblBacteria" id="EFK57258">
        <property type="protein sequence ID" value="EFK57258"/>
        <property type="gene ID" value="HMPREF0766_12331"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_10"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="859"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="885"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="911"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="957"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1032" mass="114146" checksum="2F89732A0CE0B79E" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMX7</accession>
    <name>D7VMX7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Redoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992859.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12347"/>
    <dbReference type="EnsemblBacteria" id="EFK57274">
        <property type="protein sequence ID" value="EFK57274"/>
        <property type="gene ID" value="HMPREF0766_12347"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_713531_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107719" evidence="1">
        <location>
            <begin position="20"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="246"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="387" mass="44535" checksum="48AE890318909580" modified="2010-10-05" version="1">MRTIITLIAFNLLAVQLYAQSTSIKPVESMLKQLEKIESISYNQISYDKNPFGNDTTTIYREVTVFFDPNYKLPYADVSTTIKDKNYASRTVYADKKIYNFEKDGTYTTKDYKALRIGNADIFSDGELQKTVSKIQQTAPDKIKQLNDTTIDRQDYFYFFVNAFDSVINEQRAFINMYFAVDKTTFLPKSYTIISKSNYAADNNTIELSMHSRSVFSDFNINSRKNYLLNFQIPPGYKPYEKKELLKKGTPAPEWTGKDMLENTYSSKSFAGKTLLLFMTDISCLGNQLSIGMMNNLTDKYQNKEVVVLSLFGSSKKELMQYTATNQINFPVIYDAQQIKEKYNAPGAPFFYIIDKNGYISYSVYGYNEERETTLGEELDKALSDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN27</accession>
    <name>D7VN27_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992927.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12397"/>
    <dbReference type="EnsemblBacteria" id="EFK57324">
        <property type="protein sequence ID" value="EFK57324"/>
        <property type="gene ID" value="HMPREF0766_12397"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2332217_0_0_10"/>
    <dbReference type="OrthoDB" id="2232905at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="98" mass="11154" checksum="9DDDED16FFFA62C4" modified="2010-10-05" version="1">MEFKGTKDQWLIDGNFDMSDNYRKFIRDSKGNILFDVSTLLDGQNNKKKIKEAHANAQLVIKAPEMLEMLNHILALAKCGNIVEAYKIEELIKAATKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN29</accession>
    <name>D7VN29_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992929.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12399"/>
    <dbReference type="EnsemblBacteria" id="EFK57326">
        <property type="protein sequence ID" value="EFK57326"/>
        <property type="gene ID" value="HMPREF0766_12399"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709608_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="250"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="389" mass="43396" checksum="81964D4A5F091214" modified="2010-10-05" version="1">MATQENQTTGLAIHLSQTDLQSAGAVYNTSIEYLGKRKSKFDSLIAKANANGDKLPKELDDELMQYQVTNKKAVSSIEAQRKPFTEKAHAFIKAFTAIENELGKDLYDPIQKLRDKSAKIHAEEAAEAARKEREELQRKQKRIDDIASLETQLRNGYAALLGETKRTILQVYSNFNLANAEEAKAVIQSFVNAKLSNEAWETISLVGSEELIGEVRTEERFATCSAHFTSEVTKYAEYILEMFPNRVAELEQGIADNKAAEELKQKQEQEAEEARLAAEKRAADEAAKAKQQANVTVMVAQANRQEEAPKTVESYAVVVGSVDGWRAVIEYYLTNSGTTAEDLAKVKLDSMRMFAEKQAKATGEMVEHKDVVYEPKYKAVARVSKKRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN90</accession>
    <name>D7VN90_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993006.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12460"/>
    <dbReference type="EnsemblBacteria" id="EFK57387">
        <property type="protein sequence ID" value="EFK57387"/>
        <property type="gene ID" value="HMPREF0766_12460"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2384646_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="94" mass="10785" checksum="7B53B08DFE1EE2F9" modified="2010-10-05" version="1">MKYSETFKDPLAKALKILQQKIPEGQSASLSELVTKKGGENSLKIAVMKLIDAGWTEYEFTEDFKYVKRLKLPDYAKDYLQKIWPKEAFGSASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNG1</accession>
    <name>D7VNG1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Homoserine kinase</fullName>
            <shortName evidence="11">HK</shortName>
            <shortName evidence="11">HSK</shortName>
            <ecNumber evidence="4 11">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">thrB</name>
        <name evidence="14" type="ORF">HMPREF0766_12531</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="4 11"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12531"/>
    <dbReference type="EnsemblBacteria" id="EFK57458">
        <property type="protein sequence ID" value="EFK57458"/>
        <property type="gene ID" value="HMPREF0766_12531"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0083">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041243_1_1_10"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="12">
        <location>
            <begin position="100"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="13">
        <location>
            <begin position="232"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFK57458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="326" mass="35201" checksum="77B95F9C83B103AA" modified="2010-10-05" version="1">MELSQLKKDINLEKMLDEIRVFAPATVANMICGFDILGFALDEPGDEVIMKRISTPGVVITEITGDDGRLPLDPEKNTVSACVQFLLHNLGLQHEVGVEIKLHKHMPIGSGLGSSAASTVAGLFAINALLGSPLSKEELLPYCVEGERLACGTGHADNVAPALFGGITLIRSTEPLDVISLPTPKELYAAVVFPQVDVPTRDARQLIKEKVLLKDAVTQWGNIAGLVAGLFKEDYDLIARSMHDVLIEPTRAILIPQFYEMKQIALEEGALSFGISGSGPSVVAVTRDRAIAENIKIRIQQHLNESEIESFGYVSSVNVEGPKVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP42</accession>
    <name>D7VP42_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LytTr DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12762</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993456.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12762"/>
    <dbReference type="EnsemblBacteria" id="EFK57689">
        <property type="protein sequence ID" value="EFK57689"/>
        <property type="gene ID" value="HMPREF0766_12762"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_14_1_10"/>
    <dbReference type="OrthoDB" id="1958442at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="173"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="251" mass="29332" checksum="D3B64723DAAD7F07" modified="2010-10-05" version="1">MTDKIVIVEDEKLNADRLKRLIHTIRPNACIVAVLDSVSDAVVWFSKNGMPDLVMMDIRLSDGVSFDIFEQVKIDCFIIFTTAYDEYAVQAFKYNSVDYLLKPIEQEELEVAFRKAEMYNSINTNHRSIERLLHYIQPKEYRTRFLLPFRDGYKTVQVSEVKCIYVELKAIKARLKNGTDILLSQSMEELEQQLDPRIFFRANRQFIIHIDAVQQVVNYFNGKLKVILNGIDLQIIVSREKAIVLKEWLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP57</accession>
    <name>D7VP57_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12777"/>
    <dbReference type="EnsemblBacteria" id="EFK57704">
        <property type="protein sequence ID" value="EFK57704"/>
        <property type="gene ID" value="HMPREF0766_12777"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7MQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080414_0_0_10"/>
    <dbReference type="OrthoDB" id="1502697at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032274">
        <property type="entry name" value="DUF4835"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16119">
        <property type="entry name" value="DUF4835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107754" evidence="1">
        <location>
            <begin position="20"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="297" mass="34036" checksum="ECB70E2D4ECCC258" modified="2010-10-05" version="1">MYKIVCILLLSMLITRSFAQELNIRVEVQSPQVQNTNKRALEVLQKAISDFLNNRAWTANKVQNEERIDGALVITITSWDGSKEFKGTAQVFSSRPVYGTNYNSPILAFNDKYFNFSYIEGDILDYNENQYMSNLASLLGFYANVIIGMDADSFKLYGGNTYFSVARDIVNYSQNGDYVGWRSMDAFDNRYWLITNLTDRRYVAYRDFAYNYHINGLDKMAENEPQARTEMGALLPRLKEVDRNNSGNILTSAFYSAKSNEFVGIFSRMPGNEGVKAYNLLVELDPANSTKYEEIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPG4</accession>
    <name>D7VPG4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, DeoR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">agaR</name>
        <name evidence="5" type="ORF">HMPREF0766_12884</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993685.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12884"/>
    <dbReference type="EnsemblBacteria" id="EFK57811">
        <property type="protein sequence ID" value="EFK57811"/>
        <property type="gene ID" value="HMPREF0766_12884"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060699_2_1_10"/>
    <dbReference type="OrthoDB" id="1629121at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="248" mass="27972" checksum="969CA2BD9BA24314" modified="2010-10-05" version="1">MLKQERLSTILNELHKRGVVSYAELSAVITASEDTVRRDIKELDSQGLLKAVRGGATTLSKIPHHYRQREIRDIEEKKIIARKALSLIKHNQLLFFDGGTSALELAKILPQDLRATIITNSFPVANVLEDHPTCELLFLGGRLSKTAFATYGNETLLNIQKFRADYYFFGVSSITPEELYCKDLEDAEMKREIIANSTNTIGLCTSDKLNSTDNYYVAKTKSLHMLITECDPDSTMLEHYNTIGVEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPG8</accession>
    <name>D7VPG8_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">GAR transformylase</fullName>
            <shortName evidence="2">GART</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">purN</name>
        <name evidence="4" type="ORF">HMPREF0766_12888</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993695.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12888"/>
    <dbReference type="EnsemblBacteria" id="EFK57815">
        <property type="protein sequence ID" value="EFK57815"/>
        <property type="gene ID" value="HMPREF0766_12888"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0299">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038395_1_3_10"/>
    <dbReference type="OrthoDB" id="1815747at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="3">
        <location>
            <begin position="3"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="191" mass="21886" checksum="8CF71C5A5206D027" modified="2010-10-05" version="1">MKKRIAIFASGSGSNAQKIMEHFKYSDTAEVALILSNNPESYVLQRADNFEIPSHVFDRHDFFQTDDIVKLLKNLNIDLIVLAGFLWLVPENLLKAFPNKIINIHPALLPKFGGKGMYGDRVHKAILEAKESEHGITIHFVNEHFDEGEVIYQAKFKVESGDTLEIIKFKGQQLEHLHYPKVIENLLKKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPL7</accession>
    <name>D7VPL7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993793.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12937"/>
    <dbReference type="EnsemblBacteria" id="EFK57864">
        <property type="protein sequence ID" value="EFK57864"/>
        <property type="gene ID" value="HMPREF0766_12937"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013623_0_0_10"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="747"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="773"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="961" mass="110571" checksum="44AD928C57E3079C" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPP0</accession>
    <name>D7VPP0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993823.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12960"/>
    <dbReference type="EnsemblBacteria" id="EFK57887">
        <property type="protein sequence ID" value="EFK57887"/>
        <property type="gene ID" value="HMPREF0766_12960"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108923_9_0_10"/>
    <dbReference type="OrthoDB" id="1498264at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="142" mass="16379" checksum="5EC7C0F55442CD2E" modified="2010-10-05" version="1">MKAQVVIQIVYPQPVEQVWKAITDKEAMKIWYFDIPDFQAETGRSFDFYEPGGKNEYHHFALVQQVIPYKKLKHSWANPSHSKGISVLTWELEQLDAGTQVTLTHEGLENLADGGDAFLPENYEKGWNEILHKSLKSYLNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPQ0</accession>
    <name>D7VPQ0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oxidoreduct_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993842.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12970"/>
    <dbReference type="EnsemblBacteria" id="EFK57897">
        <property type="protein sequence ID" value="EFK57897"/>
        <property type="gene ID" value="HMPREF0766_12970"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_584919_0_0_10"/>
    <dbReference type="OrthoDB" id="451569at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032459">
        <property type="entry name" value="Oxidoreduct_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16490">
        <property type="entry name" value="Oxidoreduct_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreduct_C" evidence="1">
        <location>
            <begin position="162"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="435" mass="49070" checksum="877891C94159F660" modified="2010-10-05" version="1">MKHFFRNIAILVLLGGMLSCQEQSHIALVVINPQDSTAQTVVRSMTNDLDTLVTVFNPSYSPFLQENTTFRVSETHTTDIIGALLSGRKANVAYVGGFNTERGALSERLTANGIAVLGQQPLVAGRQSMQYLQNMYRSAAETKALIYDMVPARFYEEAVIVKALLTQQEFSGGLIAGSEDTPAIVMTRHLNFVEWKDGNMIQRPVWFFDVNKQGDGFSGLAPYLDLVNWITLPEQNLDYAADVKLLKSRKWPALLNRYEFANLTGQQSYPDELKTYINPYNELAVSSNAEIRYLLQGKAVSVAVDWDYDSEEKRGDTFEGILQAVNFTVEVKSEDRRNIIYITPKESADKQVFEKKLQEILAKTGIQAVNFERTAEGRYKILLPEGINRNPDKYMASSVRTFVDYYKKGVIPEWETSFILAKYQLISDAAKQLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPV9</accession>
    <name>D7VPV9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13029"/>
    <dbReference type="EnsemblBacteria" id="EFK57956">
        <property type="protein sequence ID" value="EFK57956"/>
        <property type="gene ID" value="HMPREF0766_13029"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2920433_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="61" mass="7480" checksum="630BFE0B618B6C60" modified="2010-10-05" version="1">MRSGIRKIFLKNLFFRFWIHIRTILSCIYEFKQALKGFFAFLLTISQYINYSIVLFSCIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPW6</accession>
    <name>D7VPW6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="5">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_14326</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996443.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14326"/>
    <dbReference type="EnsemblBacteria" id="EFK57123">
        <property type="protein sequence ID" value="EFK57123"/>
        <property type="gene ID" value="HMPREF0766_14326"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1896">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039453_5_1_10"/>
    <dbReference type="OrthoDB" id="1508841at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="PTHR11845"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="6">
        <location>
            <begin position="33"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="189" mass="21839" checksum="FD2C9177437371B4" modified="2010-10-05" version="1">MFSAELLKQIDFIKEIDKIKYIQRRTKLFNSDRNENDAEHSWHLALMAIVLAEHSNEKIDLLKVLKMVLIHDIVEIDAGDTFIYDMQKNHSNTDEERRAANRIFGLLPLEQGEELIAVWEEFEAGETPEAKFARAMDRLEPLLQNSSNNGGTWNEPGVNYTKVYTKKSIIKEGAEKIWEYAETLINEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPZ6</accession>
    <name>D7VPZ6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">infC</name>
        <name evidence="8" type="ORF">HMPREF0766_13050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the IF-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13050"/>
    <dbReference type="EnsemblBacteria" id="EFK55847">
        <property type="protein sequence ID" value="EFK55847"/>
        <property type="gene ID" value="HMPREF0766_13050"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054919_3_0_10"/>
    <dbReference type="OrthoDB" id="1760144at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019813">
        <property type="entry name" value="Translation_initiation_fac3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00938">
        <property type="entry name" value="IF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="7">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="6">
        <location>
            <begin position="86"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK55847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="177" mass="20377" checksum="3C64D12F9FAAAB4F" modified="2010-10-05" version="1">MRKKEPDHRINELIRVPEVRLVGDNVEQGVFPTRKALELADELELDLVEISPNAVPPVCKIIDYSKFIYEQKKKQKEIKANAKQTVIKEIRFGPNTSEHDFDFKLKHAMRFLESGEKVRAYVHFKGRAIVHKEMGEILLLRFAQALEDYGKVELLPKLEGKRMFLTIAPKAAAAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQA6</accession>
    <name>D7VQA6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994139.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13160"/>
    <dbReference type="EnsemblBacteria" id="EFK55957">
        <property type="protein sequence ID" value="EFK55957"/>
        <property type="gene ID" value="HMPREF0766_13160"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9BM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053114_0_0_10"/>
    <dbReference type="OrthoDB" id="1079090at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="SSF48537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="315" mass="36277" checksum="447A3828892DE85B" modified="2010-10-05" version="1">MKKIYLMLPGLLICLLCSSWGFYAHKLINRNAVFTLPTELAVFYKQNIDEITEKAVDADKRCYIDSAESPRHFIDLDAYDTNTLDTLPVHWYRAKEKIEEKRLLSNGIVPWQIYITYQKLVKAFIARDKIKIIRHSADLGHYVADAHVPLHTTKNYNGQYTDQIGIHAFWESRLPEMFATHYKLTAGKAQFITDPAALGWAIVYESAPLADTVLRIEKELSVRFPASQKKTYLTRNNVLVLTYSDAYAKAYHEALNGMVEVRMRQAIHRIGSLWYSAWIEAGQPDLRKLKNKDSQPESIIPSQSPQTPMGREEWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQE1</accession>
    <name>D7VQE1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipase, patatin family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994228.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13195"/>
    <dbReference type="EnsemblBacteria" id="EFK55992">
        <property type="protein sequence ID" value="EFK55992"/>
        <property type="gene ID" value="HMPREF0766_13195"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_144_0_10"/>
    <dbReference type="OrthoDB" id="373926at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="5"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="48"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="195"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK55992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="351" mass="39739" checksum="CB9E1CB38C0B1115" modified="2010-10-05" version="1">MKRILSIDGGGIRGIIPGLLLVNLEDKLKIATNDPNAHISDFFDFFAGTSTGGILTALLLCPSEDNPNRPRFTTREALNIYLDHGPQIFSTTRWRRFLSKFGVLSELYDEKIFECVLMDYFGDIRLSQLIKPCIITAYNIELRKNHFFRQQKAISHGESRDFYIRDVCRATAAAPTYFSVAEIFSLANIRYPLLDGGVFAQNPSISALLEVLKNFNTFKITDISILSLGTGAARNAYNYEDFKKKWAISIGPALVDIMTSSSSESTDYFLRQLFRSVQRTQNYIRIEPNNLLSVESSLDAATKSNIQKLESLADRMISENEALIDDIVVDLIADRKSRNRKSAWNFLKNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQK7</accession>
    <name>D7VQK7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56058">
        <property type="protein sequence ID" value="EFK56058"/>
        <property type="gene ID" value="HMPREF0766_13261"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3239798_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="43" mass="5141" checksum="D218DFD2363D31D6" modified="2010-10-05" version="1">MYTIISIICKQQKLFIYFFHSGRIKPGVHLQEEIKSHIFVLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQU8</accession>
    <name>D7VQU8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13352"/>
    <dbReference type="EnsemblBacteria" id="EFK56149">
        <property type="protein sequence ID" value="EFK56149"/>
        <property type="gene ID" value="HMPREF0766_13352"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_87_1_10"/>
    <dbReference type="OrthoDB" id="1757088at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="165"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="271" mass="31431" checksum="54079E06B03EB553" modified="2010-10-05" version="1">MSRLSIQDDGSLSNFSDGILDIRLFRFLNTSFHHHQLDQLISPENGVLYLHTEGDTLYIPDKYYAWIPSGTIYKLISKSEQIKLRTLFLEPEKNEFHADFFNSLAVYAPNTLIEELLQFGFSHWKKERDPELKEYCIAAIRHILPVALSTPLKLFVPAPASEVLQESITYIQNHIKGPLDIQHLAQKFHLSERTLSRWFKKETGSTLFQFVKSVRVQKALELIENSRMDIIEIMHAVGYNSLSAFSTVFKELIGESPQEYKKRFQKEKVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQW0</accession>
    <name>D7VQW0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13364</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994500.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13364"/>
    <dbReference type="EnsemblBacteria" id="EFK56161">
        <property type="protein sequence ID" value="EFK56161"/>
        <property type="gene ID" value="HMPREF0766_13364"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_4_1_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="125"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="189" mass="22543" checksum="9CE936A48F804BCD" modified="2010-10-05" version="1">MKAYESISDSELLLYLAEKDHTAFTELYTRHWKVVYAICINRIKEPAIAEDLVQDIFLSLWTHAQPQNIRNLEAYLFQATKFSIIKHINKSQKHLYTNEYGLFDQLEDYNLDEVLHYKWVKELIFQEVEKLPLKTQLIFRYSRQDHLNSKEIADKLDISPRTVENQISKVLKILRKVVKTIIFFAFFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQX4</accession>
    <name>D7VQX4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994516.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13378"/>
    <dbReference type="EnsemblBacteria" id="EFK56175">
        <property type="protein sequence ID" value="EFK56175"/>
        <property type="gene ID" value="HMPREF0766_13378"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503453C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2048245_0_0_10"/>
    <dbReference type="OrthoDB" id="2151241at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="120" mass="13468" checksum="F01930C68B39B297" modified="2010-10-05" version="1">MKAISSPGLFTFQKYIGIVVTVIGALIFIFDRRPEASAPLMIGLFTLYISKSRVEDERSSSLKTSSLYIAFILAYTLKLISSNLFSHGIAGIQIMEVDHFIILTFGIALITYYIRLYFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR14</accession>
    <name>D7VR14_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ricin-type beta-trefoil lectin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13418</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994573.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13418"/>
    <dbReference type="EnsemblBacteria" id="EFK56215">
        <property type="protein sequence ID" value="EFK56215"/>
        <property type="gene ID" value="HMPREF0766_13418"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3979">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_440677_0_0_10"/>
    <dbReference type="OrthoDB" id="324607at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042279">
        <property type="entry name" value="Pep_M60_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031161">
        <property type="entry name" value="Peptidase_M60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13402">
        <property type="entry name" value="Peptidase_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01276">
        <property type="entry name" value="M60-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51723">
        <property type="entry name" value="PEPTIDASE_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107552" evidence="1">
        <location>
            <begin position="25"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M60" evidence="3">
        <location>
            <begin position="85"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="477"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="620" mass="68111" checksum="014D6DC395256A00" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR26</accession>
    <name>D7VR26_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-70 region 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994592.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13430"/>
    <dbReference type="EnsemblBacteria" id="EFK56227">
        <property type="protein sequence ID" value="EFK56227"/>
        <property type="gene ID" value="HMPREF0766_13430"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_4_3_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="16"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="114"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="169" mass="20363" checksum="9D5879E9437941D9" modified="2010-10-05" version="1">MKLRKRSDIHLIEAYFEQYYEMLCKVAFQYVKDHQEAEDIVQDFFYLLWQKNRAEKIEGKFEHYAVRSIRNNCLNVLKKKQLPIQDISSDFYNLGEDHDDMELRIAYEQRLEDVAASIQLLPDRQREAIDMNIWGDLKYQEISDRLQVSINTVKTHIKLAYKNLRRLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR56</accession>
    <name>D7VR56_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994625.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13460"/>
    <dbReference type="EnsemblBacteria" id="EFK56257">
        <property type="protein sequence ID" value="EFK56257"/>
        <property type="gene ID" value="HMPREF0766_13460"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1481127_0_0_10"/>
    <dbReference type="OrthoDB" id="2102989at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="181" mass="21520" checksum="2CDE0D2E6DD4CE5D" modified="2010-10-05" version="1">MTAKEFVKNINETQISIDYLRENYSEGYVKDMLKETIIPELSKEYVEHGNEILNLVLNYDLELFRVVEIHFDKDLFEDDNSIFFGWDGVGDRLGFDMDTKEVFTYYVYGDSITFYCAPNDKIFLDLLFEVHKFQNNRIHALDNQQKRSLEKTFMIYINAYFGNNKKYVDFYASTIGYDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VR92</accession>
    <name>D7VR92_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994673.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13496"/>
    <dbReference type="EnsemblBacteria" id="EFK56293">
        <property type="protein sequence ID" value="EFK56293"/>
        <property type="gene ID" value="HMPREF0766_13496"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033FMC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1320229_0_0_10"/>
    <dbReference type="OrthoDB" id="1226052at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="208" mass="22586" checksum="37A3290732EAF88B" modified="2010-10-05" version="1">MNVIKSLFGISVLALAVACGDSANKSKDGKKTGEVALHQLADSTDAKKHFYFTIKEDGTSDSSVFYVAKGLYNTDTVGLRLEVLSDIQPGINADGTPNEDNGFRKGAIKISSLGAQSDAFVKSAAHLFKIPESKPMLSSPILPTVFSSNKGKVDLTKNGTYSFKLFFDIPNDKQAEVFAVIDTYKNSFEITEKDSTFRTQFLKAFTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRB6</accession>
    <name>D7VRB6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartokinase</fullName>
            <ecNumber evidence="10">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">lysC</name>
        <name evidence="13" type="ORF">HMPREF0766_13520</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="10"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994702.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13520"/>
    <dbReference type="EnsemblBacteria" id="EFK56317">
        <property type="protein sequence ID" value="EFK56317"/>
        <property type="gene ID" value="HMPREF0766_13520"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0527">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_6_0_10"/>
    <dbReference type="OrthoDB" id="1067792at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="12">
        <location>
            <begin position="2"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="5"/>
            <end position="8"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="218"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFK56317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="437" mass="48341" checksum="59B2DF7BF6831B11" modified="2010-10-05" version="1">MKILKFGGTSVGSAARIKGLLDIVNPSERQIVVLSAVAGTTNALVEISQAYLVGKKDEAKQLIKQHKDKYESLIKELFTTDQGYKNGKDLIDYHFDFIGSLSNEHFTPIEEKVVLAQGELISTALFHFHLNEIGVPSVLLPALDFMKIDEDNEPMVSYIGEKLNALLAKYPDNTLFITQGFICRNSFGEIDNLRRGGSDYTASLIGAAIQADEVQIWTDIDGMHNNDPRVVKNTTPIAHLSFNEAAELAYFGAKILHPQSVFPAQKYNVPVRVLNTMDPKAAGTLISKDGAQKGIIRAIAAKDNITAIHIHSSRMLLAYGFLRKVFEIFERYKTPIDMITTSEVAVSLSIDDTTHLADIIKEVEDFGTVSADENQTIVCVVGDFGQNTHGYAARVLDAVKHLPIRMISYGGSDYNVSILMDSEYKTEALRSLHNRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRD6</accession>
    <name>D7VRD6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994725.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56337">
        <property type="protein sequence ID" value="EFK56337"/>
        <property type="gene ID" value="HMPREF0766_13540"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50345KN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_927189_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107275" evidence="1">
        <location>
            <begin position="27"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="300" mass="34407" checksum="07ED26D92F49D135" modified="2010-10-05" version="1">MKIISCHLLYLSLLFTLTFCSGSAQKQEQEMIWLVFQPKVELNKSVALRLFFKNKPETGSIKVHSSDKDNYKELEGSEIEREMESQADLYFYDITFEAGSLGKSDLPIIEAKIDGKIYKSSAEIIEVVEKQDVDINAVKLVLETDKDRYNIDDTIRLALYEYSKFSQISKFTPEDLVKKGAPEALFAIIDSGNVDYEVGILGFKKYIDAHFNVANYDWNVNDIGKRMATLDGQLYIKNRIFNMKMVAKEKGIFTIPQSRFDYKIYPYAEAFKEELLGSDETLRTKNKIPAQSNSLKIIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRN1</accession>
    <name>D7VRN1_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994880.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13635"/>
    <dbReference type="EnsemblBacteria" id="EFK56432">
        <property type="protein sequence ID" value="EFK56432"/>
        <property type="gene ID" value="HMPREF0766_13635"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032SVM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168831_0_0_10"/>
    <dbReference type="OrthoDB" id="1278667at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="16"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="126" mass="14693" checksum="3562C7EA5127A0D9" modified="2010-10-05" version="1">MKTLADHYLSLQEPHKSCLLALRDIILSLDPDITHELKYGMPFFCYKGKMFCYLWIHKSYDQPYIGIVEGKHLTHPLLITEKRARMKIMLLDSDQDLPLSLIKDILYQAIQLYKDGTIAIPNKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRT4</accession>
    <name>D7VRT4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995021.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13688"/>
    <dbReference type="EnsemblBacteria" id="EFK56485">
        <property type="protein sequence ID" value="EFK56485"/>
        <property type="gene ID" value="HMPREF0766_13688"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2156747_0_0_10"/>
    <dbReference type="OrthoDB" id="1739513at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="111" mass="12425" checksum="B5790CADFB2DA262" modified="2010-10-05" version="1">MNYVYFIAFWACQCVSTVLFKYGGIHPRYKWLTLIIGNIILLSASWFLVQLFRSVSQPIVIALCSGGTFLTVQLTMALYFKSPLTWAQILGMFIIISGMVLITFGGKGESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRU0</accession>
    <name>D7VRU0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase, alpha subunit</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ribE</name>
        <name evidence="4" type="ORF">HMPREF0766_13694</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995039.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13694"/>
    <dbReference type="EnsemblBacteria" id="EFK56491">
        <property type="protein sequence ID" value="EFK56491"/>
        <property type="gene ID" value="HMPREF0766_13694"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034388_2_0_10"/>
    <dbReference type="OrthoDB" id="1276859at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="96"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="96"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="196" mass="21266" checksum="9633BC719483CA3F" modified="2010-10-05" version="1">MFTGIIETLGRVKDVISEDSNLHLYVESAISNELKIDQSISHNGVCLTVVGLEGNIHKVTAIDETLKKSNLGKLKAGDIVNLERCTLIGGRLDGHIVQGHVDQTAVCTAKEDQNGSTIFTFTYSPDTQNMTVEKGSVTVNGISLTVVGSKDHEFSVAIIPYTLEHTNLGQIHVGDEVNLEFDIVGKYVAKIMSLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRX4</accession>
    <name>D7VRX4_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF262 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995122.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13728"/>
    <dbReference type="EnsemblBacteria" id="EFK56525">
        <property type="protein sequence ID" value="EFK56525"/>
        <property type="gene ID" value="HMPREF0766_13728"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038557_1_0_10"/>
    <dbReference type="OrthoDB" id="1779628at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="DUF262"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF262" evidence="1">
        <location>
            <begin position="47"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="384" mass="44984" checksum="ECD1DBFFE6DF9F39" modified="2010-10-05" version="1">MNQYNITEEEASDIEKEIGNEEIVIEVPFKPEDINIKIVPRNIGQLVELLEDKQILIPKYQRLPNLWNNTKKSRFIESLMLDLPIPLFYFDEGDNKKWYVVDGLQRMSTLEHFMLGTGEVGKNNSQLKLENLEFLTEYNHKTWNDLPKDIKRRINSNQVTINLIGKGTPDEVKYTIFSRINQGDVPLTSQEIRTALFQGYRVDFLEKLVSKETEVGQLFHKVTSGSIKTRRQEDLDFVSRFVSFYIQGYSNYEPDMDRFITTGTKLIPENEVDRRKMVIDFKKALDISWEIFGNDSFRKRQSINDGRKPINKPLFEIISTVFSKLTDDETRELLKNKKEFVTSFIELQNDNKRFWNAITTGTATKDNVNLRNKEFSAFLSNFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRY3</accession>
    <name>D7VRY3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995144.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13737"/>
    <dbReference type="EnsemblBacteria" id="EFK56534">
        <property type="protein sequence ID" value="EFK56534"/>
        <property type="gene ID" value="HMPREF0766_13737"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503035H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1730230_0_0_10"/>
    <dbReference type="OrthoDB" id="1956922at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="152" mass="17636" checksum="31334E5200B4E20B" modified="2010-10-05" version="1">MEWNKIKADTQNIYPENSITLFLMDTDSGKPATCWVDKAYADYPYKQECMFNCFISVDLLNDEFNLRNEDLDYGDIEDYFTQQLREVCVCHIVARITTDSGISIEMYVDDVESAIGKLNELEADPNRLVNFDCEISDDENWDNVDNLLNDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRY4</accession>
    <name>D7VRY4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995146.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13738"/>
    <dbReference type="EnsemblBacteria" id="EFK56535">
        <property type="protein sequence ID" value="EFK56535"/>
        <property type="gene ID" value="HMPREF0766_13738"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033I86">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138392_0_0_10"/>
    <dbReference type="OrthoDB" id="2006656at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="175" mass="20632" checksum="5308353F3BFAD6CA" modified="2010-10-05" version="1">MLTLRSTEQIKQDILSQGKALSTFPQSVDFPFALSYTDLVKEIRTREISSECTLFAAAEAWKETSAFADPGYWPETYTRQDIDRFWIFGQNGQGDLWLFDREHKLYFYDHNQAQMGLHNFVELHIDFDSWLQYADLNSQLDEIYYREGEINEACKDDYTRKLQHMGSALLQLFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS23</accession>
    <name>D7VS23_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aconitate hydratase 2 domain protein</fullName>
            <ecNumber evidence="11">4.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">acnB</name>
        <name evidence="11" type="ORF">HMPREF0766_13777</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="11"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995241.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13777"/>
    <dbReference type="EnsemblBacteria" id="EFK56574">
        <property type="protein sequence ID" value="EFK56574"/>
        <property type="gene ID" value="HMPREF0766_13777"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_314657_0_0_10"/>
    <dbReference type="OrthoDB" id="32104at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015933">
        <property type="entry name" value="Aconitase_B_HEAT-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036288">
        <property type="entry name" value="Aconitase_B_HEAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015929">
        <property type="entry name" value="Aconitase_B_swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06434">
        <property type="entry name" value="Aconitase_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11791">
        <property type="entry name" value="Aconitase_B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74778">
        <property type="entry name" value="SSF74778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Aconitase_B_N" evidence="10">
        <location>
            <begin position="6"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_2_N" evidence="9">
        <location>
            <begin position="179"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase" evidence="8">
        <location>
            <begin position="411"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFK56574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="934" mass="102254" checksum="04E8CABDB7691199" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS66</accession>
    <name>D7VS66_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995344.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13820"/>
    <dbReference type="EnsemblBacteria" id="EFK56617">
        <property type="protein sequence ID" value="EFK56617"/>
        <property type="gene ID" value="HMPREF0766_13820"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073843_0_0_10"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="180"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="275" mass="32026" checksum="EC257C5FB7C4E13C" modified="2010-10-05" version="1">MNEQQEDIYDTLSYSGVFLSCFSEYGTHCVHSKPEHVLVYIYSGEQVIVDRNKKTIIKAGECAFIRRDNRLQMFKNSKGTDCYKGISLTFQRNVLREFYSKMNKADIPKDVPISDKKAFKLKQSPAIESLFQSLTPYFDSNVKPTEGVTHLKLLEGIYALLNSSEQFYPILFDFADPWKIDLLEFLNENYMQELSMEQIAAFTGRSLATFKRDFKKISSLTPQKWLINKRLEMAYIKLKEEKKKVQEVYTEVGFKNLSHFSTAFKRQYGIPPTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSA8</accession>
    <name>D7VSA8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995452.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13862"/>
    <dbReference type="EnsemblBacteria" id="EFK56659">
        <property type="protein sequence ID" value="EFK56659"/>
        <property type="gene ID" value="HMPREF0766_13862"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017617_1_0_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041700">
        <property type="entry name" value="OMP_b-brl_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14905">
        <property type="entry name" value="OMP_b-brl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMP_b-brl_3" evidence="1">
        <location>
            <begin position="368"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="796" mass="90804" checksum="82C7CE7522B46C5B" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSB0</accession>
    <name>D7VSB0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain protein</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995457.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13864"/>
    <dbReference type="EnsemblBacteria" id="EFK56661">
        <property type="protein sequence ID" value="EFK56661"/>
        <property type="gene ID" value="HMPREF0766_13864"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082973_0_0_10"/>
    <dbReference type="OrthoDB" id="1431378at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="47"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="206" mass="23859" checksum="9958956103AE7417" modified="2010-10-05" version="1">MAEHNKTEFWESAFNDKQEMWGFEPSKSAVLTKDLFVQKDLRNILIPGVGYGRNAQIFKDKGIKVTGIEISETAIRMAEKHYGTDMLIYHGSVTDMPFDKEFYDGIFCYALIHLLNEDERKKLIRDCYNQLLPGGYMVFTVISKSAHTYGQGRMISTDRYEIYEGVHMFFYDEDSIRAEFGAFGLFGITEIDENQPFYLIKCQKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSD2</accession>
    <name>D7VSD2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_13886</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995505.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13886"/>
    <dbReference type="EnsemblBacteria" id="EFK56683">
        <property type="protein sequence ID" value="EFK56683"/>
        <property type="gene ID" value="HMPREF0766_13886"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_3_6_10"/>
    <dbReference type="OrthoDB" id="381612at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="208"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK56683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="290" mass="31999" checksum="C08ED48127705232" modified="2010-10-05" version="1">MTSEDKAIKTTYFSIAGNTALALLKWLAGFFGNSYALIADAIESTVDILSSFLVLLGLKYAKRPADENHPYGHGRVEPLITFIVVGFLIVSATIIAYESIQNIGTPHELPKPWTLAVLAGIIIWKEISFRIVIKKSKETGSSSLKADAWHHRSDAITSVAAFIGISIALTMGKGYESADDFAALFAAGFILYNCYHIFRPALGEIMDENVYEDIIEQVKENAILVEGVLGTEKCFVRKSGTTFHVDLHAIVEADIPVREGHRIAHKLKDFLRAKMPQLGHVLIHIEPNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSZ1</accession>
    <name>D7VSZ1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995891.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14095"/>
    <dbReference type="EnsemblBacteria" id="EFK56892">
        <property type="protein sequence ID" value="EFK56892"/>
        <property type="gene ID" value="HMPREF0766_14095"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0790">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018089_0_0_10"/>
    <dbReference type="OrthoDB" id="100869at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032774">
        <property type="entry name" value="WG_beta_rep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14903">
        <property type="entry name" value="WG_beta_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="820" mass="96375" checksum="3DA10C1182DAF1D4" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTG1</accession>
    <name>D7VTG1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996335.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14265"/>
    <dbReference type="EnsemblBacteria" id="EFK57062">
        <property type="protein sequence ID" value="EFK57062"/>
        <property type="gene ID" value="HMPREF0766_14265"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_10"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="155" mass="18036" checksum="8412913750C00945" modified="2010-10-05" version="1">MMENKKITVLYVDDEENNLLSFKATFRLKYEVHTAISGADAIEIVKKNPVNVIITDQRMPEMTGVEFLEEIIKLDPHPMRILLTGYTDMAAVIDAVNKGKIFHYLNKPWSEEELDQTIIRAYEAYNEREKIIETNSQLETSNEQLEFLLRQKLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTR8</accession>
    <name>D7VTR8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK55827">
        <property type="protein sequence ID" value="EFK55827"/>
        <property type="gene ID" value="HMPREF0766_14388"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3140832_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="49" mass="5495" checksum="BD20831CA2E75460" modified="2010-10-05" version="1">MAKVEIFFELHKSFLQKICPPVILNLLFSVVIPSETTIPPLRSGAKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTT6</accession>
    <name>D7VTT6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002228.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14406"/>
    <dbReference type="EnsemblBacteria" id="EFK55715">
        <property type="protein sequence ID" value="EFK55715"/>
        <property type="gene ID" value="HMPREF0766_14406"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3015">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095662_0_0_10"/>
    <dbReference type="OrthoDB" id="2029962at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007298">
        <property type="entry name" value="Cu-R_lipoprotein_NlpE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04170">
        <property type="entry name" value="NlpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="147" mass="16652" checksum="DA0BF82E62C1155A" modified="2010-10-05" version="1">MKTRVYILATLLLFIILGSCINNRQNKTERSNDAAYSISPDGTIEQKSDQFTGEYKGILPCADCDGIETILHINADKSYQLSTKYLGKSDENFVKSGRWKMHANTLTLEGIDYKFRILDDQLSQLDLSGNDIKGDLADQYRLAKFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTU2</accession>
    <name>D7VTU2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nupG</name>
        <name evidence="2" type="ORF">HMPREF0766_14412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002239.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14412"/>
    <dbReference type="EnsemblBacteria" id="EFK55721">
        <property type="protein sequence ID" value="EFK55721"/>
        <property type="gene ID" value="HMPREF0766_14412"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013133_1_2_10"/>
    <dbReference type="OrthoDB" id="791272at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004740">
        <property type="entry name" value="Nuc_H_symport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03825">
        <property type="entry name" value="Nuc_H_symport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00889">
        <property type="entry name" value="2A0110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="458" mass="51856" checksum="31A49BEBC5A8F201" modified="2010-10-05" version="1">MSIKFRLTIMNFIQFFVWGAWLITIANFWFGTKQWDGTQFGAIFATMGIASLFMPTLIGIIADRWVNAERLYCILHILYGAILFYLPQVDNPGSFFYVMLAAMCCYMPTLALSNSIAYTALIKNNYDLVKSFPPIRVWGTVGFIAAMWIVNLSGNKATAIQFYIAGTAAIALGLYALTLPKNTPQKLIKENATWMQTFGLEAFKLFGNYKMALFFIFSMFLGGALQLTNAYGDVYIDEFKFFPKYAELLVVKYSTIIMSISQISETLFILAIPFFLKRFGIKKVMLISMIAWVLRFGLFAYGNPQDGLWMIILSCIVYGMAFDFFNISGSLFVETSTDSKIRSSAQGLFMMMTNGFGAVLGSLISGWVIDHYFTMSFQDIGQLATFLQSEVTNIHFMAFLKDKGVAISATGAFEKPLHLKDWHHIWLAFSAYTLVIAVLFALLFKHKHDPKQLEKTYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTV7</accession>
    <name>D7VTV7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ribosomal protein S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsA</name>
        <name evidence="3" type="ORF">HMPREF0766_14427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002268.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14427"/>
    <dbReference type="EnsemblBacteria" id="EFK55736">
        <property type="protein sequence ID" value="EFK55736"/>
        <property type="gene ID" value="HMPREF0766_14427"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015805_2_0_10"/>
    <dbReference type="OrthoDB" id="1235756at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="90"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="171"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="258"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="343"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="430"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="517"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK55736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="644" mass="72201" checksum="721469CBECE10A5C" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGF5</accession>
    <name>D7VGF5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5675 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002005.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10074"/>
    <dbReference type="EnsemblBacteria" id="EFK60130">
        <property type="protein sequence ID" value="EFK60130"/>
        <property type="gene ID" value="HMPREF0766_10074"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032SV8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114144_2_0_10"/>
    <dbReference type="OrthoDB" id="1769702at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043732">
        <property type="entry name" value="DUF5675"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18925">
        <property type="entry name" value="DUF5675"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5675" evidence="1">
        <location>
            <begin position="5"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="134" mass="15114" checksum="412BD49300755952" modified="2010-10-05" version="1">MVLELIREYSAGGTNGKLYYDGVLVCYTIELPWHNNRRRISCIPEGRYRLMKRHSPKFGWHIVVLNVPGRSAILFHPANYALKELQGCIAPVTALMGSGRGVDSRTALEVLKALVYPVLDIDECVFVVIRSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGJ7</accession>
    <name>D7VGJ7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_10116</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996618.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10116"/>
    <dbReference type="EnsemblBacteria" id="EFK59199">
        <property type="protein sequence ID" value="EFK59199"/>
        <property type="gene ID" value="HMPREF0766_10116"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_833947_0_0_10"/>
    <dbReference type="OrthoDB" id="1585225at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="333" mass="38017" checksum="7656EAE63AA0AE99" modified="2010-10-05" version="1">MTAKVLKIFGIIIVVGCLVLFLVQTDFKMLGDTLDQVGYRFIILILITAIAYILATAGWYYCMAPTGQRISLYRLFFVRQVGETIGLFNPTNVIGGDLFKVHMLRSENLSKEEVTHSVFLSRVMAILSQLLLLAAVLCWYSLQLMQRKEPTIIYTGGFLIATLILGAIVCSMLYITKKRSSPMRTAEPVIKLNFWLKIKYRITHILRQTSVFYQHYPSYFWYSFFFFTLHWFVGSLEFYVILRLLEANASPMDGLFIDMGVIIVKSLGAFIPGQIGIEELGNKIMLSGIGLTGTAIWISASVLRRARQLVWTFISLICYFLFYKFNGSLIRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGP1</accession>
    <name>D7VGP1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996761.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10160"/>
    <dbReference type="EnsemblBacteria" id="EFK59243">
        <property type="protein sequence ID" value="EFK59243"/>
        <property type="gene ID" value="HMPREF0766_10160"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_823624_0_0_10"/>
    <dbReference type="OrthoDB" id="1339129at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="225"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="325" mass="37495" checksum="C4A7971081A60A51" modified="2010-10-05" version="1">MEITHENGVDPYWIYSFAQKMGGEVEGSFLKIPAEVLEGTCYFLKVSDTISTFIIDAVFNQPLTFHLRNTKNNFVTLHFDFTEGDAFHILDNVANPVGRWEYNVALYDSSLDADYVVKEGSTTYSIDIHIDKKELRRILSGFPQFRDVLNTMFDSEKNTFLRYGRTSNKAWWLINELRNTNQEDPLYDIIAKSTVYNLLSDYLDQILNQEILLEKVVKEDLVAIIDSQSFLLNLIESAFPGIKDLAARAMMSETKYKTLFRKITGLSPNAFFLQNKLTYAKQMLETGQHTISEVTAHYNFANASYFADQFKKFYGIPPKDYLTHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGR8</accession>
    <name>D7VGR8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_10187</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996818.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10187"/>
    <dbReference type="EnsemblBacteria" id="EFK59270">
        <property type="protein sequence ID" value="EFK59270"/>
        <property type="gene ID" value="HMPREF0766_10187"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050164_1_0_10"/>
    <dbReference type="OrthoDB" id="1712258at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="136" mass="15346" checksum="EBDFBE271CF9FE88" modified="2010-10-05" version="1">MNFYTRKWIKPEDLNPNGTLFGGTLLRWIDEEAVIYAIVQLGNPFVVTKYISEINFVSSARQGDIIELGIEAIAFGTTSLTMKCEVRNKITRKTILSIEKLVFVNLNEEGTPTPHGRTEITYAYMGIERINKGDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGT6</accession>
    <name>D7VGT6_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996866.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10205"/>
    <dbReference type="EnsemblBacteria" id="EFK59288">
        <property type="protein sequence ID" value="EFK59288"/>
        <property type="gene ID" value="HMPREF0766_10205"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7XI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074321_0_0_10"/>
    <dbReference type="OrthoDB" id="1410112at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP10" evidence="1">
        <location>
            <begin position="74"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="321" mass="38384" checksum="3187DD189A0000FF" modified="2010-10-05" version="1">MINIKRIIFKNKNFKIAYYFKALLREIPNSFWYRSRLKSKLQSAYKFDSKVLEERVNYYNKLQVNTSLASSAMPIAEFKIPEKIRVYYFDTKEYVRYFDPKLRLQMIPGDVVDIPEYPAIVKSRPIAGDNKNAVLLNLDKIRHFNFIRDDIPFRNKKDLLIGRFAAYQQHRKRFFELYFGHQLCDLGSVVMDNDHPEWYGKPISIQQHLDYKFILSLEGNDVATNLKWIMSSNSVAVMPLPKYETWFMEGKLIPDFHYIQIKDDYSDLEEKLHYYIDHPQEAEKIVDNAHQYIQQFNNRKLEDLIALRVLEKYFKKTNQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGX3</accession>
    <name>D7VGX3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydropteroate synthase</fullName>
            <shortName evidence="1">DHPS</shortName>
            <ecNumber evidence="1">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">folP</name>
        <name evidence="3" type="ORF">HMPREF0766_10242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="1"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996968.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10242"/>
    <dbReference type="EnsemblBacteria" id="EFK59325">
        <property type="protein sequence ID" value="EFK59325"/>
        <property type="gene ID" value="HMPREF0766_10242"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0294">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008023_0_2_10"/>
    <dbReference type="OrthoDB" id="1275854at2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="2">
        <location>
            <begin position="24"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="280" mass="30972" checksum="195CB9565E29A304" modified="2010-10-05" version="1">MNMMHSTPAQSVNAKGRLITFDYPRIMGILNVTPDSFFDGGQHQHLDAALKKAEQLLEDGADILDIGAYSSRPGAALISVQEELDRAIPVIEKMASIFPHTILSIDTFRAEVAEQSIRAGAHIINDVSGGTLDDQMFATVAKLQVPYILMHMRGVPENMQEMTTYDDIVTDIATFLGSRISALRSLGVKDIILDPGFGFAKSMQQNYELLHRIDELHYFGLPILGGLSRKSMIYKKLNLTPEHALNGTTALNTVLLSKGVQLLRVHDVKEARQIVDLLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH11</accession>
    <name>D7VH11_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_10280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997077.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10280"/>
    <dbReference type="EnsemblBacteria" id="EFK59363">
        <property type="protein sequence ID" value="EFK59363"/>
        <property type="gene ID" value="HMPREF0766_10280"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004317_2_1_10"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106934" evidence="5">
        <location>
            <begin position="25"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="117"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="448"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK59363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1074" mass="118044" checksum="40A74FF503AEAAB6" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH29</accession>
    <name>D7VH29_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate kinase, FGGY family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_10298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997118.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10298"/>
    <dbReference type="EnsemblBacteria" id="EFK59381">
        <property type="protein sequence ID" value="EFK59381"/>
        <property type="gene ID" value="HMPREF0766_10298"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_3_0_10"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="3"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="259"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="492" mass="54190" checksum="950D09305CA2DDF1" modified="2010-10-05" version="1">MLLLGIDLGTSSIKVSVVSADTQEIIVSVSYPEEEAEILSPQAGWAEQSPEVWWDYTIKAVLKAHNSKKYDPREIRAIGLSYQMHGLIVVDKQDKVLRNAIIWCDSRSVAIGERAWEDMGKAQTLRQHLNSPGNFTASKLAWIKQNEPDIYDQIAKILLPGDFLTLKFTGEINTTVSALSEGIFWNFEKNDVSSAILDYFGFDRSLIPDINPVFSHHGTVKSEIAALLNLSADTVVSYKAGDQPNNALSLNVLNAGEVAATAGTSGVIYGVSDELTFDPQSRVNTFAHVNYLPDDIRTGILLCINGTGIQNSWIRKMIGADLSYNELNVLGQQAPVGSRGLKILPFGNGAERMLNNKLIHSHIQQIDFNKHGKAEIVRASQEGIAFAFRYGLDILRENGLHPSVIRAGHTNLFLSPLFCDSFVNVTDTPVELFNNDGSVGAALGAGIGVGYYKESKEAFQHMKKISTIEPTEAAVYEELYQEWKMLLSKLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH85</accession>
    <name>D7VH85_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sigma-70 region 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpoE5</name>
        <name evidence="3" type="ORF">HMPREF0766_10354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997234.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10354"/>
    <dbReference type="EnsemblBacteria" id="EFK59437">
        <property type="protein sequence ID" value="EFK59437"/>
        <property type="gene ID" value="HMPREF0766_10354"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_16_1_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="32"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="193" mass="22776" checksum="B7D54E48AF3A13D2" modified="2010-10-05" version="1">MSKFSKSFTPENDQEIIDGILIGDHLALDAIYKLYYPSISHMIIQNNGSEEEAKDIFQEAVIVLYDKVSHGDFELKSKLKTYLYSICRRLWLKQLNRNGAGYATNDIRDYEDTLQYEDDIDKHEELDLRFAQMEEAMNKLGEPCKTILHDFYILNRSMQDICEKFGYTNTDNAKTQKYKCLQRLKKYFFQSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VH96</accession>
    <name>D7VH96_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hmgA</name>
        <name evidence="4" type="ORF">HMPREF0766_10365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002997256.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10365"/>
    <dbReference type="EnsemblBacteria" id="EFK59448">
        <property type="protein sequence ID" value="EFK59448"/>
        <property type="gene ID" value="HMPREF0766_10365"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053101_0_0_10"/>
    <dbReference type="OrthoDB" id="193687at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="PTHR11056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="385" mass="44808" checksum="44B234462771220A" modified="2010-10-05" version="1">MPIYHQLGKVPQKRHTIFRKPNGELFSEELVSTHGFSSTYSLVYHCYPPTLVKQIRDPYDVSPRIAREKHLKHTSLKGFKIQPKDDYLESRTPVLVNQDLHVSLAAPRLSMLDYFYKNSQADEIIFIHEGSGVLKTGYGKIRFEYGDYLVIPRGVIYQLHFDNPDNRLFIVESFSPIRTPKRYRNEFGQLMEHAPFCERDIKRPEDLETIDQTGEFEIRIKKQGLIYPYVYGSHPFDFVGWDGYHYPWAFSIHDFMPLTGKLHQPPPVHQTFETETFVLCSFCPRLYDYHPQSIPAPYNHSNVDSDEVLYYVDGDFMSRKSVERGQITLHPGGIPHGPHPGTVEKSIGQTKTEELAVMIDPFRPLMLTEEALEIEDQEYYKSWIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VI70</accession>
    <name>D7VI70_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DegT/DnrJ/EryC1/StrS aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pglE</name>
        <name evidence="4" type="ORF">HMPREF0766_10689</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998009.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10689"/>
    <dbReference type="EnsemblBacteria" id="EFK59772">
        <property type="protein sequence ID" value="EFK59772"/>
        <property type="gene ID" value="HMPREF0766_10689"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_2_1_10"/>
    <dbReference type="OrthoDB" id="1722208at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="377" mass="41761" checksum="CDE521665BDFFF3B" modified="2010-10-05" version="1">MSDKIWLSSPHMGGNELKYIHEAFDANWVAPLGPNVNGLEEDLEKFLNKNVKVAALSAGSAALHLALIECEVGYGDEVICQSMTFSASANPIAYQGAIPVFIDSEPDTWNMDPIQLKGAIQDRIAKGKKPKAIIVVHLYGMPAKMDEILTIATEFDIPVIEDAAEALGSTYKGRSCGTFGRFGILSFNGNKIITTSGGGALVCHNQEDKDKAVFLSTQARDNAPHYQHSHIGYNYRMSNISAGIGRGQMEVLSDRVNARRSMHDFYTHIFKNIEGVTVFSEPTADFYSNHWLSAITVDATITSKTREDLRLAFLEDNIESRPLWKPMHLQPVFQDSPYYGKKVAEKLFDNGLCLPSGSNLTDSDRERIKNVVEHVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIC0</accession>
    <name>D7VIC0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="15">ATP-PFK</shortName>
            <shortName evidence="15">Phosphofructokinase</shortName>
            <ecNumber evidence="15">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">pfkA</name>
        <name evidence="17" type="ORF">HMPREF0766_10739</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 15">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="15"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998108.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10739"/>
    <dbReference type="EnsemblBacteria" id="EFK59822">
        <property type="protein sequence ID" value="EFK59822"/>
        <property type="gene ID" value="HMPREF0766_10739"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020655_0_1_10"/>
    <dbReference type="OrthoDB" id="1421302at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00339">
        <property type="entry name" value="Phosphofructokinase_I_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012828">
        <property type="entry name" value="PFKA_ATP_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02482">
        <property type="entry name" value="PFKA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="12 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 15 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="16">
        <location>
            <begin position="6"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator; shared with dimeric partner" evidence="15">
        <location>
            <begin position="24"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="173"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator" evidence="15">
        <location>
            <begin position="189"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator" evidence="15">
        <location>
            <begin position="216"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="254"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="105"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFK59822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="324" mass="35135" checksum="3235738DB04994CF" modified="2010-10-05" version="1">MSKIKNIAVLTSGGDAPGMNAAIRAVVRTGIYYNLNVFGIRRGYDGMVSGDIISMDAKSVANIIQRGGTILKTARSDEFRTIEGRQKAYENLRKHEIDALVVIGGDGTFTGASKFIEEFDFPVMGLPGTIDNDLLGTDFTIGYDTAINTVVDAVDKIRDTAESHDRLFVIEVMGRDSGLIALRSGISTGAEAVLIPEIKVDYDAIMTRLDKTRKNKASRIIIVAEGDQEGGMVVADKIKESFPSYDVRLSILGHIQRGGSPTCMDRVLASRVGVGAVEGLIEGRRGEMVGLIHGEVKYTPFSKAIKHIDKIDDNLTRIVEILSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIG5</accession>
    <name>D7VIG5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-70 region 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_10784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998197.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10784"/>
    <dbReference type="EnsemblBacteria" id="EFK59867">
        <property type="protein sequence ID" value="EFK59867"/>
        <property type="gene ID" value="HMPREF0766_10784"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_1_4_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="130"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="188" mass="22206" checksum="79A09073C931C9BE" modified="2010-10-05" version="1">MIQQNRVNCKMLQSGNKKSTIMTRNEFNTQVMEQTNELRSFAKRFTKDNEEINDLLQETFLKAVTYFQNFKEGTNLKGWLYTIMKNTFINGYRRVSKTQSFITTEEEVSSSQMYFSAVHNWGENKFVMDDIQQALSELDKGCYVPFTMYFEGYKYYEIAEHLNLPVGTVKTRIHMARKKLKNVLAVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIK3</accession>
    <name>D7VIK3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_10822</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998267.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10822"/>
    <dbReference type="EnsemblBacteria" id="EFK59905">
        <property type="protein sequence ID" value="EFK59905"/>
        <property type="gene ID" value="HMPREF0766_10822"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_1_0_10"/>
    <dbReference type="OrthoDB" id="406005at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="25"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="265"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK59905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="541" mass="61708" checksum="A06E1C00193724F5" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIP2</accession>
    <name>D7VIP2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydroxymethylglutaryl-CoA reductase (NADPH)</fullName>
            <ecNumber evidence="2">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hmgA2</name>
        <name evidence="5" type="ORF">HMPREF0766_10861</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10861"/>
    <dbReference type="EnsemblBacteria" id="EFK59944">
        <property type="protein sequence ID" value="EFK59944"/>
        <property type="gene ID" value="HMPREF0766_10861"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001734_2_2_10"/>
    <dbReference type="OrthoDB" id="617929at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="PTHR10572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="SSF55035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="SSF56542"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK59944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="451" mass="49025" checksum="873BC0AC68CA4D18" modified="2010-10-05" version="1">MQNIIIDCHKFNNENRNMFVFTNINYMASSIEKANKALHRIETEIGNIIHSIKNRRPAELTVDCTLPLSAEVNREGMLQRHSFLQKITGKQFPFLSGEEIGEPDRLNGNIENYIGMSCVPTGVIGPLRIIGSAANADFYVPLATSEGALLASYHRGARACFVAGGITSICLIEGVQRSPLFKFENVGELGLFVSWLLPQEEKLKEITKQTSRFARLTCIQIQIEGNHLIVTFEYQTGDAAGQNMVTICTDTICQYLIAHSPVKPKLWFVEGNYSGDKKATALSFTNVRGKKVTAEIVLPETIVQQVLKTTPELMAEYWRSSTMGIIQSGAIGAHGHYANGLAALFLATGQDVACVAEAATGITRMELNKDGSLYASVTLPNLMVGTVGGGTHLSTQRECLEIMDCYGAGQARKFAEICGGLVLAGELSIAAALSAGHFTSAHQKFGRKKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIS7</accession>
    <name>D7VIS7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pseudouridine synthase, RluA family</fullName>
            <ecNumber evidence="2">5.4.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">truC</name>
        <name evidence="2" type="ORF">HMPREF0766_10896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998426.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10896"/>
    <dbReference type="EnsemblBacteria" id="EFK59979">
        <property type="protein sequence ID" value="EFK59979"/>
        <property type="gene ID" value="HMPREF0766_10896"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_11_4_10"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="230" mass="26695" checksum="6E9D9BB12F2B9099" modified="2010-10-05" version="1">MLDILYQDQEIVAINKPHGLLVHRSPIARDASEFALQLLRDQLQQRVYPAHRLDRKTGGILLFSLTKEMDKSLQQLFQDRKMNKSYLAVVRGYTEDDGQINYPLKKDNGEEQEALTHYKTLSRSEIDLPTGNFTTSRYSLVEANPETGRMHQLRKHFAHIFHPILGDRPHGCNKQNKLWKERFEMDTMMLHASQLSFEHPTTGNIVHIKAPLQPEFERVLSILKLESPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VIW5</accession>
    <name>D7VIW5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Quinolinate synthase</fullName>
            <ecNumber evidence="2 9">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">nadA</name>
        <name evidence="10" type="ORF">HMPREF0766_10934</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate</text>
            <dbReference type="Rhea" id="RHEA:25888"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="2.5.1.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the quinolinate synthase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="2 9"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998506.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10934"/>
    <dbReference type="EnsemblBacteria" id="EFK60017">
        <property type="protein sequence ID" value="EFK60017"/>
        <property type="gene ID" value="HMPREF0766_10934"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0379">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047382_0_0_10"/>
    <dbReference type="OrthoDB" id="613347at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00568">
        <property type="entry name" value="NadA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023066">
        <property type="entry name" value="Quinolinate_synth_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="131"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="217"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK60017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="332" mass="36964" checksum="4AD1E0B6FF94F14C" modified="2010-10-05" version="1">MNITYERDLEAKGYIDVAIDPTIDLVEEINRLKKEKNAVILAHYYQESEIQDIADYIGDSLGLSQQAAKTDADVIVFAGVHFMAETAKILSPSKKVLLPDLKAGCSLSDSCPPHLFAKFKEKYPDHLVITYVNCTAELKALSDIVCTSSNAVQIVESLPLDQKIIFGPDRNLGAYVKKKTGRDLILWNGACMVHEIFSQDKIDALRIEYPDAKFIAHPECEDHILAGADYVGSTSGMLKFTMNDPSQVYIVATESGIIHQMQKASLEKTFIPAPPNNACACNDCPHMKLNTLEKLYNCLKFESPEITLPEDVILRAQKPIERMLEISERLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJ00</accession>
    <name>D7VJ00_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK60052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998571.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10969"/>
    <dbReference type="EnsemblBacteria" id="EFK60052">
        <property type="protein sequence ID" value="EFK60052"/>
        <property type="gene ID" value="HMPREF0766_10969"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_14_4_10"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="104" mass="11830" checksum="D90DFCD5807D389F" modified="2010-10-05" version="1">MLQELENDTLQEIVDNNDIVMVQYSASWCGNCRIMKPKFKKLAGENENVSFIIVDAEKFPESRKLANVNNLPTFAAFKNGKLINQVQTNKFEGLIDLFNETTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJH0</accession>
    <name>D7VJH0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11139"/>
    <dbReference type="EnsemblBacteria" id="EFK59023">
        <property type="protein sequence ID" value="EFK59023"/>
        <property type="gene ID" value="HMPREF0766_11139"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038716_5_1_10"/>
    <dbReference type="OrthoDB" id="302683at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107018" evidence="1">
        <location>
            <begin position="26"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="372" mass="40468" checksum="59D7B32C1BA3AD57" modified="2010-10-05" version="1">MNTLRTCLIPMIFLCTLLMPFPGIAQTNVPLFVGTYTQPGKSKGIYIYDFNQKSRQANLLSTTSCNNPSFLARSKDGKTLYAVSEKNDGTENLSAYHFDGKQLTFLNEVNVRGADPCHVSLSNTDPIAVVSNYSGGSFAVFRLNTDGSIAARDTLVQHSGKGIDASRQDKPHVHSAFFAPDFKTIFVQDLGTDKISIYPVKQTNGIYGVGTPSIIQTPAGGGPRHIAITKDGKSFYVVTEMTAKVVAYAKKKDKWELIQEIDINRAGFSGGNGAAEIKLSPDGKFVYASNRGDANVITAFKVLKDRTLIVVDTYNVGGKGPRNFNFSPDGQSILVGNQYTDNITLFKRDIATGSLQKLESDINIFSPVCIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJN2</accession>
    <name>D7VJN2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11201</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000004">
        <property type="protein sequence ID" value="EFK59085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11201"/>
    <dbReference type="EnsemblBacteria" id="EFK59085">
        <property type="protein sequence ID" value="EFK59085"/>
        <property type="gene ID" value="HMPREF0766_11201"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZC2G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108467_0_0_10"/>
    <dbReference type="OrthoDB" id="2016648at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106959" evidence="3">
        <location>
            <begin position="40"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="185"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="218" mass="25021" checksum="FDA18D65096ECBA7" modified="2010-10-05" version="1">MNMKLIYNTTDCMNFKKLFCYISATLLFAILSFPSGSTAQTSAFKYSNDGLKKGTIESQFQHLNYISRTQDPYKLIRKENLDIIKKNVQDSIARLSQEINTLKSSSTNFASSTKALQDSVKNVSQELEKERSKTDSISFIGIPFSKATYHTMVWAIIIVLALLFLITLASFRKAKVDTVDHKKTTDQLQDELQTLRKKSMENEQKLRRQLQDEINKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VJV8</accession>
    <name>D7VJV8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_11277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11277"/>
    <dbReference type="EnsemblBacteria" id="EFK58560">
        <property type="protein sequence ID" value="EFK58560"/>
        <property type="gene ID" value="HMPREF0766_11277"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044440_3_0_10"/>
    <dbReference type="OrthoDB" id="1851189at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107031" evidence="2">
        <location>
            <begin position="29"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="236"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="271" mass="30053" checksum="22C708D98C09C282" modified="2010-10-05" version="1">MKTILGKLTRTGVIATLYYAAMSAQGFAQTNTFPASGPVGIGTTSPKAILDIAAPYIHNGRLGTVLGRLLEGDVTGEGTFLGVRGYGTQYSEQYGWKSFALEHSFYGYINSSINFLRGDDATGGFLTFNTDNNTERMRLDTEGKLLLGTTVSRGELLSVNGHIRAKEIKVEAANWPDYVFKKDYELKPLADLDAYIKEYGHLPDMPKAAEAEKEGVSLGEMNKLLLKKVEELTLHLIEKDNEIKISNRKLKDIENKQKELELLLQKVIDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D7VK50</accession>
    <name>D7VK50_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">msrA</name>
        <name evidence="6" type="ORF">HMPREF0766_11369</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002998927.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11369"/>
    <dbReference type="EnsemblBacteria" id="EFK58652">
        <property type="protein sequence ID" value="EFK58652"/>
        <property type="gene ID" value="HMPREF0766_11369"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_10_2_10"/>
    <dbReference type="OrthoDB" id="1554384at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="36"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="216" mass="24467" checksum="CBD8D94130565898" modified="2010-10-05" version="1">MKYSIITLIIFTLSVGLVRSKNTNSDPLTEGGNTQEIYFAGGCFWGTEHFFKQINGVKSTEVGYANGKTKNPTYDIVSHTKSGYAETVKVRYDPEKVALKTLIELYFKTIDPTSLNRQGNDIGEQYRTGIYYKDEKDLSVIKTCIAALSKNYLKPLAIEVKPLTNFYKAEDYHQDYLDKNPQGYCHIDPALFEMARKANQDTTKNKGKDSKKTSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKD1</accession>
    <name>D7VKD1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_11450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11450"/>
    <dbReference type="EnsemblBacteria" id="EFK58733">
        <property type="protein sequence ID" value="EFK58733"/>
        <property type="gene ID" value="HMPREF0766_11450"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3122810_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="50" mass="5857" checksum="E83CC0F3DA5CD88A" modified="2010-10-05" version="1">MPLGSIYDKFGPYQAQLVSQATKPISIANIKKYFKFVQSYEIYLKKIIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKN2</accession>
    <name>D7VKN2_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
            <shortName evidence="8">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">valS</name>
        <name evidence="13" type="ORF">HMPREF0766_11551</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11551"/>
    <dbReference type="EnsemblBacteria" id="EFK58834">
        <property type="protein sequence ID" value="EFK58834"/>
        <property type="gene ID" value="HMPREF0766_11551"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_0_2_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="28"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="621"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Val_tRNA-synt_C" evidence="12">
        <location>
            <begin position="819"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="541"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFK58834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="884" mass="102068" checksum="A1CEBBAE65555FEC" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKS4</accession>
    <name>D7VKS4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11593"/>
    <dbReference type="EnsemblBacteria" id="EFK58876">
        <property type="protein sequence ID" value="EFK58876"/>
        <property type="gene ID" value="HMPREF0766_11593"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013076_0_0_10"/>
    <dbReference type="OrthoDB" id="385673at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003106991" evidence="1">
        <location>
            <begin position="21"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="941" mass="108779" checksum="F7CD4DBA986EC99F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKT6</accession>
    <name>D7VKT6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999494.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11605"/>
    <dbReference type="EnsemblBacteria" id="EFK58888">
        <property type="protein sequence ID" value="EFK58888"/>
        <property type="gene ID" value="HMPREF0766_11605"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_833716_0_0_10"/>
    <dbReference type="OrthoDB" id="1847256at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="353" mass="39836" checksum="54ACF634DE699627" modified="2010-10-05" version="1">MAATKQDIFAKIGDLLLELNDQYATCSEHENCDLIEISLLEAKARFLADHINILKTLNLQETTTNNQQPVHEVTETYKVNSEVEKVPFETYFTPSSQVEKEEVDEQPVHEEIVENMPETTNIVQEESAIQEETIEEYTEANDTEQYHNDITGESEEELVQNSEPEEIVADKAEPQPVQENIRFETPVSFSQPESAPVQPAPVSTTPVQQPEPLNEPPIAEPVVNTVIIEEKSIVVEESVEEKPSRPLTLNELISQQKKAGLGQGNIFQTSQNGTERISDLKVAVSLNDKLLFIKDLFNGYSLAYSEAIELLNRFDNLAEADAFLQTNYALKNGWSDKPQTVEKLYAILRKKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D7VKV3</accession>
    <name>D7VKV3_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rluB</name>
        <name evidence="6" type="ORF">HMPREF0766_11622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="ACHA02000005">
        <property type="protein sequence ID" value="EFK58905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999529.1">
        <property type="nucleotide sequence ID" value="NZ_GL379772.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11622"/>
    <dbReference type="EnsemblBacteria" id="EFK58905">
        <property type="protein sequence ID" value="EFK58905"/>
        <property type="gene ID" value="HMPREF0766_11622"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024979_0_3_10"/>
    <dbReference type="OrthoDB" id="1037615at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="5">
        <location>
            <begin position="207"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="441" mass="50405" checksum="A96C4A64D4691C8F" modified="2010-10-05" version="1">MPFSRNRNSRDDNSKRSRSNSENFKSKGNSSRSEKSSGYNDNKSPRKSFSKSSDSNDRPDRFEKTEGSKTGGYKKSFDGKKSFGEKRSFGEKKAFGDKKAYGDKKPFGERNAFGEKKAFGDRKPFGDKKAYGDRKPGSDKRFGDQKFSKSGPRDKNRDFGDNRKFDKPYKKSFETSEDAEQRTFAKRRPSSRTVKQATSDYDDNGMIRLNRYISNAGICSRRKADELITAGVISVNGEVVTELGSKVDPAKDEIKYNGERLKREKMVYVLLNKPKDYITTTDDPQERRTVMQLVANATKERIYPVGRLDRNTTGLLLLTNDGNLAEKLSHPRNNISKIYNVELDKSLNQGDFNKIVFGLELEDGFVKPDDLSYVQGGSKREVGIQIHSGKNRIVRRIFESLGYDVVKLDRVVYANLTKKDLPRGRWRYLEEKELIQLKHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL02</accession>
    <name>D7VL02_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase, S41 family</fullName>
            <ecNumber evidence="6">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ctp</name>
        <name evidence="6" type="ORF">HMPREF0766_11671</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S41A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999679.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11671"/>
    <dbReference type="MEROPS" id="S41.004"/>
    <dbReference type="EnsemblBacteria" id="EFK58275">
        <property type="protein sequence ID" value="EFK58275"/>
        <property type="gene ID" value="HMPREF0766_11671"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017295_2_1_10"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="96"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="530" mass="59056" checksum="D7B03BBA05D56953" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL31</accession>
    <name>D7VL31_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atoB2</name>
        <name evidence="7" type="ORF">HMPREF0766_11700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999742.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11700"/>
    <dbReference type="EnsemblBacteria" id="EFK58304">
        <property type="protein sequence ID" value="EFK58304"/>
        <property type="gene ID" value="HMPREF0766_11700"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_0_10"/>
    <dbReference type="OrthoDB" id="330994at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="268"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK58304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="390" mass="41621" checksum="FC51C954180E81BA" modified="2010-10-05" version="1">MEAYIVAGYRTAVGKAPRGGFRFTRADDLAADVIKHLVASVPNLNKEEIDDVIVGNAMPEAEQGLNVARLISLMGLQTDKVPGVTVNRYCASGLETIATAVAKIKSGMADCIIAGGVEVMSGMPFGGWKIVPNPEVAKENPDWYWGMGLTAEAVAKEYNVNREDQDKFSLRSHQRAVEAIKNGHLKDGVVPVTVKENYLKDGKIATREYVVDTDEGPRADSTLEVLSKLKPVFAADGCVTAGNSSQTSDGAAFVLVVSEKKMKELNLQPIARLVSYAVAGVPPRIMGIGPIYAIPKALEQAGLNLQDIDLIELNEAFASQSLAIIRELGLDEEKVNVNGGAIALGHPLGCTGAKLTVQVLNELKRRNKKYGMVTMCVGTGQGAAGIFELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL35</accession>
    <name>D7VL35_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999746.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11704"/>
    <dbReference type="EnsemblBacteria" id="EFK58308">
        <property type="protein sequence ID" value="EFK58308"/>
        <property type="gene ID" value="HMPREF0766_11704"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033V49">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1260786_0_0_10"/>
    <dbReference type="OrthoDB" id="2130518at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="219" mass="25706" checksum="9AC6D2FFDF50F79B" modified="2010-10-05" version="1">MKLEDLKYNNRQNSPTTSSALLFLPQEAIEKLTTQKPTNLLDTIDENLKKNIRYRSLFILVATGILLYNYDNTFWGWYFILGSLVEAGMTYIAYKLRKKIHESFETDLPLSDRFIQIQELIRKYLKFNKTARGSILVILAIAVSLKNIQSFDLPSLFSGDVILRFFILGLIFYFIHFYSFKKFAKPHQDMLVDLHYYLKELEELPQEDIQTHTQKNAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VL66</accession>
    <name>D7VL66_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_11735</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002999811.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11735"/>
    <dbReference type="EnsemblBacteria" id="EFK58339">
        <property type="protein sequence ID" value="EFK58339"/>
        <property type="gene ID" value="HMPREF0766_11735"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010638_0_0_10"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="7">
        <location>
            <begin position="485"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK58339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1075" mass="123306" checksum="B1BBE905342F3A25" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLH4</accession>
    <name>D7VLH4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl hydrolase family 3 N-terminal domain protein</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nagA3</name>
        <name evidence="5" type="ORF">HMPREF0766_11844</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000133.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11844"/>
    <dbReference type="EnsemblBacteria" id="EFK58447">
        <property type="protein sequence ID" value="EFK58447"/>
        <property type="gene ID" value="HMPREF0766_11844"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008392_5_3_10"/>
    <dbReference type="OrthoDB" id="949956at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107385" evidence="3">
        <location>
            <begin position="22"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="4">
        <location>
            <begin position="48"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK58447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="569" mass="63515" checksum="3C783CA710B339C3" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLN2</accession>
    <name>D7VLN2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_11902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000006">
        <property type="protein sequence ID" value="EFK58505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000260.1">
        <property type="nucleotide sequence ID" value="NZ_GL379773.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11902"/>
    <dbReference type="EnsemblBacteria" id="EFK58505">
        <property type="protein sequence ID" value="EFK58505"/>
        <property type="gene ID" value="HMPREF0766_11902"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032SB9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_911857_0_0_10"/>
    <dbReference type="OrthoDB" id="1605620at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="305" mass="34627" checksum="1992B9D438DA8CA4" modified="2010-10-05" version="1">MELNFEFKKERKLGEFVQDFVDLLKIVIRHFCATLFRLAVIPLAILLLLVFYLTTKVDFNADFSAGDMMQIWGLFIGIVCALLLLSTLFFGIAIEYFILLKNQNNLDFGSTEVWNNFKSNFAKYFRFFGASILVMLIMIIPFFFVLIIASFIPFVGNIVAGVLMSLIGVWLFCAFMLYREGYYSLGSCFSEAYHLLKKKVYDYGVSSYIVSAIFQVMLMMMTLIPALILGLIAYNTVGFNDNFFDTFSGKLIVSLGGTIFSLVTITSYMFSVLISGLIYESAKELRFGENIYETINNIGKEANGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLR9</accession>
    <name>D7VLR9_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent dethiobiotin synthetase BioD</fullName>
            <ecNumber evidence="5">6.3.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DTB synthetase</fullName>
            <shortName evidence="5">DTBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Dethiobiotin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">bioD</name>
        <name evidence="6" type="ORF">HMPREF0766_11939</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the dethiobiotin synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.3" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000007">
        <property type="protein sequence ID" value="EFK58221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003000959.1">
        <property type="nucleotide sequence ID" value="NZ_GL379775.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11939"/>
    <dbReference type="EnsemblBacteria" id="EFK58221">
        <property type="protein sequence ID" value="EFK58221"/>
        <property type="gene ID" value="HMPREF0766_11939"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072551_2_0_10"/>
    <dbReference type="OrthoDB" id="1739932at2"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43210">
        <property type="entry name" value="PTHR43210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006755">
        <property type="entry name" value="DTB_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00347">
        <property type="entry name" value="bioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="99"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="184"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK58221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="206" mass="22734" checksum="4319D585C21006E7" modified="2010-10-05" version="1">MKQQIFISGIGTGIGKTVCAAVLTRFWGADYWKPIQSGDLHYSDSMLVRELAGKHAIIHPERYRLRLAASPHESAAAENLQIALEDFELPDTPRPLVVEGAGGLFVPINEEAFIIDLISKLSIPAALVIRDYLGCINHSLLSLAALQQRNIPIRHLILNGSFNPHSERIICRAVGSATSILRIPDLESLSSQEVDRVCCDRFDKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLU0</accession>
    <name>D7VLU0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prepilin-type cleavage/methylation N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gspG</name>
        <name evidence="2" type="ORF">HMPREF0766_12194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001586.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12194"/>
    <dbReference type="EnsemblBacteria" id="EFK58202">
        <property type="protein sequence ID" value="EFK58202"/>
        <property type="gene ID" value="HMPREF0766_12194"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153249_0_0_10"/>
    <dbReference type="OrthoDB" id="1792530at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043683">
        <property type="term" value="P:type IV pilus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031982">
        <property type="entry name" value="PilE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16732">
        <property type="entry name" value="ComP_DUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK58202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="138" mass="15659" checksum="AD3F6048414C98C5" modified="2010-10-05" version="1">MKIINQRRLKAYTLTEILVVLVIIGILILLALPNLLPLITKAKSTEAKMQLQHVQTLQQNYFYEKSKYSGNLEELGFVQEKLSTDGKDGKANYRIEIVKADQNSFIAKATAVVDFDGDGTFNVWEIDQDKNLREVTPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLU6</accession>
    <name>D7VLU6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001595.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12200"/>
    <dbReference type="EnsemblBacteria" id="EFK58208">
        <property type="protein sequence ID" value="EFK58208"/>
        <property type="gene ID" value="HMPREF0766_12200"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033E8S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139195_0_0_10"/>
    <dbReference type="OrthoDB" id="2075091at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK58208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="161" mass="19177" checksum="8D6B5023746AFB17" modified="2010-10-05" version="1">MDNQLTLSMYIEILKEQFMELREINKTNANINITDELESVMKINSEWSYLLFFECVELFEKSRFCVSYWKDEDNWMTLSDESNIIAYIWRGYPLIFLDEKFITVVKNMVSDKYDSVLISAPNLARNIFKIDGDFNLIDFDLGFNKKSFSAEDFWYHTNDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VLX0</accession>
    <name>D7VLX0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_11967</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK57975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_11967"/>
    <dbReference type="EnsemblBacteria" id="EFK57975">
        <property type="protein sequence ID" value="EFK57975"/>
        <property type="gene ID" value="HMPREF0766_11967"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_4_1_10"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014327">
        <property type="entry name" value="RNA_pol_sigma70_bacteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02985">
        <property type="entry name" value="Sig70_bacteroi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="34"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="128"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="189" mass="22638" checksum="2DA3EA864FB06D29" modified="2010-10-05" version="1">MSTGKRSDENKSRDMYRAKEEEPLRLLFNDVFYTYEKALFRLALNTCKDEHVAHDIVHDVFLKLWEIRQQLHEIKSIESFLFTMTRNKIMDHLRKVASDARLRQAIWESMQTIVDNHPAPVEYKEYKEILRKAVDNLPEQRKAIYLMRDEGYNYQEIADEFDISRHTVKNQISAAMKSIRKVFSKFLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMF0</accession>
    <name>D7VMF0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001487.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12147"/>
    <dbReference type="EnsemblBacteria" id="EFK58155">
        <property type="protein sequence ID" value="EFK58155"/>
        <property type="gene ID" value="HMPREF0766_12147"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_655372_0_0_10"/>
    <dbReference type="OrthoDB" id="776281at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107122" evidence="2">
        <location>
            <begin position="22"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK58155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="418" mass="46013" checksum="08CC310D563B9123" modified="2010-10-05" version="1">MSGNNLLLLAALLLAVTSCSPKTTGVLRSPDYKGGNTGAVTEKKDKDKTTVKELSPAEQKAAAKRAMVNQIALILPFQLTSVNTSLLSENDVKRSALALDFYQGFQTGLDDLAKQGTNFTLNVLDSRDDVVRTTAIAKSDDVQYASLIVGPIYPKEIKTFGANSVNRKILQVSPLAATMPTEFNNPNLVSLTPPIRVHMREMAKEIIREYNTGDVVIVYNTGDADHKQFLTGFDTEIAGAKKKLDVRSVTSIDQLNQSLTQTGKNIIVTGTTSAVQLRALLSNLDTKSLESPYKFALFGHPTWDKFDFKAFSNVDDYSITISSSFVLSSYSSAVRKFKTTYKDTYGVEPSEYSFKGYDAAQYFGRLIAKYGKDYAAHVESEEFDGLSNSFKFQYNAAWGYVNNAVGFLVYRNGAFQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMF7</accession>
    <name>D7VMF7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase Obg</fullName>
            <ecNumber evidence="5">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cgtA</name>
        <name evidence="5" type="synonym">obg</name>
        <name evidence="9" type="ORF">HMPREF0766_12154</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000010">
        <property type="protein sequence ID" value="EFK58162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001499.1">
        <property type="nucleotide sequence ID" value="NZ_GL379776.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12154"/>
    <dbReference type="EnsemblBacteria" id="EFK58162">
        <property type="protein sequence ID" value="EFK58162"/>
        <property type="gene ID" value="HMPREF0766_12154"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0536">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011747_2_3_10"/>
    <dbReference type="OrthoDB" id="603226at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
        <property type="entry name" value="GTP_bd_Obg/CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="8">
        <location>
            <begin position="5"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="7">
        <location>
            <begin position="164"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="170"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="195"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="217"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="285"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="312"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFK58162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="332" mass="35912" checksum="B2ADB9DA18538FC8" modified="2010-10-05" version="1">MAQGSNFVDYVKVCCRSGHGGAGSAHLHRDKHTAKGGPDGGDGGRGGHIILKGTSQLWTLLHLKYRKHIIASNGDPGGSALRSGANGKDEILEVPLGTIARDAETGEVLFDITEDGETKILTAGGIGGLGNWHFKSATQQTPRFSQPGRPGIEQWVILELKVLADVGLVGFPNAGKSTLLSVVSAAKPEIANYPFTTLVPNLGIVSYRDNKSFVMADIPGIIEGASEGKGLGYRFLRHIERNSVLLFMVPADTDRTIAEEYHILLKELTAYNPELMDKPKLLAITKSDMLDEELENEMKAQVPDNIPYIFISSITGKNILQLKDMIWKAINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMM0</accession>
    <name>D7VMM0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative RNA polymerase-binding protein DksA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dksA</name>
        <name evidence="6" type="ORF">HMPREF0766_12240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992681.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12240"/>
    <dbReference type="EnsemblBacteria" id="EFK57167">
        <property type="protein sequence ID" value="EFK57167"/>
        <property type="gene ID" value="HMPREF0766_12240"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1734">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043144_3_1_10"/>
    <dbReference type="OrthoDB" id="1932026at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="5">
        <location>
            <begin position="56"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK57167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="128" mass="14438" checksum="F8446E41521A7B03" modified="2010-10-05" version="1">MADNTEKTRYSDVELQEFKSIILEKLRVAKEELSSLTKSLNNSNANGTDDTAGTYKTLEDGSATLEKEQTNQLAARQKKFIDNLEAALVRIENKTYGICRETGKLIQKERLKAVPHTTLSIEAKNKQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMW8</accession>
    <name>D7VMW8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992843.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12338"/>
    <dbReference type="EnsemblBacteria" id="EFK57265">
        <property type="protein sequence ID" value="EFK57265"/>
        <property type="gene ID" value="HMPREF0766_12338"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030P2Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1249875_0_0_10"/>
    <dbReference type="OrthoDB" id="1284307at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="211" mass="24339" checksum="3A4EA90B2A25EB2B" modified="2010-10-05" version="1">MTFQHIFYIPTIFLLGLIFGILLSNNTSTASAEGKMNGKKLGLVFLIFIIVFIITHSFNVPAGSKQVSMLLGGQEIFDKKPIFGSDAVYHYVQSLPETGLRVYKRFTYTIDIIFPLSMLAFLHTFCRFTLERVKLRKYLSKIVRFLPWTWFGFDMLENATVFYLLSEFPKQYPLVAGSLAWITVTKFVLLFLSLLVPALLLLFAKKLKYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMY7</accession>
    <name>D7VMY7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992875.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12357"/>
    <dbReference type="EnsemblBacteria" id="EFK57284">
        <property type="protein sequence ID" value="EFK57284"/>
        <property type="gene ID" value="HMPREF0766_12357"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030U2D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156607_0_0_10"/>
    <dbReference type="OrthoDB" id="2079084at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="131" mass="15261" checksum="A71561C96AFCB78D" modified="2010-10-05" version="1">MTKNIRYFILLLVVGLVLYGVHYAILKGLDLQDVWQQTDYKLWGFYLVGGISSLVMLIVVIIIHNMMPNSVGFVFLGLLTLKMIVSFLYVNKGLNQQPENFIEYNFLAVFFLFIVYDVFMAYKVMNQENKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VMZ5</accession>
    <name>D7VMZ5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent Clp protease adaptor protein ClpS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">clpS</name>
        <name evidence="2" type="ORF">HMPREF0766_12365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12365"/>
    <dbReference type="EnsemblBacteria" id="EFK57292">
        <property type="protein sequence ID" value="EFK57292"/>
        <property type="gene ID" value="HMPREF0766_12365"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134083_2_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ClpS" evidence="1">
        <location>
            <begin position="31"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="101" mass="11758" checksum="69F0198686679B91" modified="2010-10-05" version="1">MKITYFCIMSVQTQEETYSLEEILAAAKSSNRLILWNDETNTFDHVIECLMKHLQYTEKQAEQIAWKVHTEGKCAILEGSFTEMEVYRKIFKSEGLTVSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VN79</accession>
    <name>D7VN79_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_12449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002992993.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12449"/>
    <dbReference type="EnsemblBacteria" id="EFK57376">
        <property type="protein sequence ID" value="EFK57376"/>
        <property type="gene ID" value="HMPREF0766_12449"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZXJ4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2411674_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="92" mass="10900" checksum="38ACEFF5BDCCAC7B" modified="2010-10-05" version="1">MKDLTPYRINAMLNYNRTRRTVLVEIRPGNMAPNTYTLFNKEKTSMYVFRKDDDEWLQHYGQPFETDLFYAITQMLDEIDQDINGIGIDVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNA4</accession>
    <name>D7VNA4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993025.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12474"/>
    <dbReference type="EnsemblBacteria" id="EFK57401">
        <property type="protein sequence ID" value="EFK57401"/>
        <property type="gene ID" value="HMPREF0766_12474"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_3_10"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="180"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="281" mass="33040" checksum="53614B8FF9E3068E" modified="2010-10-05" version="1">MKIQKEEVKFEAGRSFKLFTPSFRGYFMWHYHAEIELVYVEAINGIRHVGKHISDFMDSDLVLIGSNVPHLNFDYAIKTEYEQTVVQFRDDFPDVLIKSIPEFEKITHMLERSYLGLAFHGNTKAEVAKRLKSIDNTDSFKSLLGIIEILQMLANSEEVEILNKENTRVKWFLNDKVRMGTIYDYVSTNYHKKPDVNEIAELVHLNPSSFCRYFRRQTDMTFTDFVNHYRINLAKTLLLQEETIAEVCYRVGYESISYFNKTFKKLIGETPSSFKKKYLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VND8</accession>
    <name>D7VND8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993075.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57435">
        <property type="protein sequence ID" value="EFK57435"/>
        <property type="gene ID" value="HMPREF0766_12508"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032Y90">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1488155_0_0_10"/>
    <dbReference type="OrthoDB" id="2012381at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107377" evidence="2">
        <location>
            <begin position="28"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="181" mass="21046" checksum="F942FE87B3454304" modified="2010-10-05" version="1">MAFYIFPRKHMKAFLIMTVMLSLWSCGNPDKSISSANDRNTDQETDSIQNNRPADTTVKEKRVREVYPEPIDEESMQRAEISKTDSMIHVYNNIRADYRVFGYSKPDTTSQKMFLISVFTNDVKDNPYKCLYGSYYDSASMPDMSIKYMADAGAFIKANLYQDDVLLAPVYLERKWVEFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNF3</accession>
    <name>D7VNF3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993091.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12523"/>
    <dbReference type="EnsemblBacteria" id="EFK57450">
        <property type="protein sequence ID" value="EFK57450"/>
        <property type="gene ID" value="HMPREF0766_12523"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007251_3_1_10"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="379"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="573" mass="66017" checksum="069364E51F2142DA" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNH0</accession>
    <name>D7VNH0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase, pyridine binding domain protein</fullName>
            <ecNumber evidence="2">2.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tktC</name>
        <name evidence="2" type="ORF">HMPREF0766_12540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993115.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12540"/>
    <dbReference type="EnsemblBacteria" id="EFK57467">
        <property type="protein sequence ID" value="EFK57467"/>
        <property type="gene ID" value="HMPREF0766_12540"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3958">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_1_1_10"/>
    <dbReference type="OrthoDB" id="900125at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="10"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="317" mass="33985" checksum="70E9984A6F3817B0" modified="2010-10-05" version="1">MKKYTYTESKDTRSGFGAGLLEAGKQDENVVALCADLIGSLKMNDFIKEFPERFFQIGIAEANMMGIAAGLTIGGKVPFTGTFANFSTGRVYDQIRQSIAYSDKNVKIAASHAGLTLGEDGATHQILEDIGLMKMLPGMTVINPCDFNQTKAATIAVAKHHGPVYLRFGRPVVPNFTPADQEFVIGKAILLNEGTDVTIIATGHLVWEAIQAGEKLAELGISAEIINIHTIKPLDEEAVLKSVGKTKCVVTAEEHNRLGGLGDSVAQVLAQHLPTPQEYVAVNDSFGESGTPAQLMEKYGLNAEAIVAAAQKVIKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNI7</accession>
    <name>D7VNI7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Site-specific recombinase, phage integrase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12557</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12557"/>
    <dbReference type="EnsemblBacteria" id="EFK57484">
        <property type="protein sequence ID" value="EFK57484"/>
        <property type="gene ID" value="HMPREF0766_12557"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033139_2_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035386">
        <property type="entry name" value="Arm-DNA-bind_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025269">
        <property type="entry name" value="SAM-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17293">
        <property type="entry name" value="Arm-DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13102">
        <property type="entry name" value="Phage_int_SAM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="226"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="413" mass="47850" checksum="07AAF1983ECCC696" modified="2010-10-05" version="1">MDMKSKNTFGIQFVLRLPKNKKDEMATVYARITVNGRRTEISLKSKVSINNWDEVKGRAKGKRQEIVKLNSHMEQVRSLIFDCYHQLVQQNKTVTIEAVKSVYLGEDIEETMTLLKLVEYHKQVAVSKLAPGTMKNYYTTETYIQKFIKQKYGKKDIPLDELNYRFILDFENFLNDYKPKDHHKPINNNGVMKHMERLRKMVNLAVTMDWLVRDPFAKYKLRFEKVERGHLSKEELTVLLNKSFSIERLQSVSDMFIFSCYTGLAYIDIFNLTPENISKGIDGKDWLTTKRQKTDTTVRVPLLPEASDLLKKYRGHPVAEANGTIFPVISNQRMNGYLKEIAEICGINKNLTFHLARHTFATTVTLSNGVPIESVSKMLGHTSIRTTQIYAKVLEHKLSEDMHKLEVRMASQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNM7</accession>
    <name>D7VNM7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993186.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12597"/>
    <dbReference type="EnsemblBacteria" id="EFK57524">
        <property type="protein sequence ID" value="EFK57524"/>
        <property type="gene ID" value="HMPREF0766_12597"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9HA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1304222_0_0_10"/>
    <dbReference type="OrthoDB" id="912299at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="211" mass="23691" checksum="25F9BBB4936F1CDD" modified="2010-10-05" version="1">MEIVIVICLLIVIVLLLQDKIIIKKRSKQKPPQKKVNPDLPDIMGQPKPVERLSVPNTANERQIEEPEVNPDNLDIEYDENENRSIQIPQEELDEVFSNQPDFEEEEEEWNRYGISGGDNGFAQGVTFEELSSVGMLLQQEKLESSQKETAIAIVQKIQGTELFSLLENSIAGASSKIAKLLDSSLSSETEISSSTLRNNDLDDFDIGEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNN9</accession>
    <name>D7VNN9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TraG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_12609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993205.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12609"/>
    <dbReference type="EnsemblBacteria" id="EFK57536">
        <property type="protein sequence ID" value="EFK57536"/>
        <property type="gene ID" value="HMPREF0766_12609"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019050_1_1_10"/>
    <dbReference type="OrthoDB" id="246216at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032689">
        <property type="entry name" value="TraG-D_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025988">
        <property type="entry name" value="YWFCY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12696">
        <property type="entry name" value="TraG-D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14293">
        <property type="entry name" value="YWFCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="YWFCY" evidence="3">
        <location>
            <begin position="5"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="TraG-D_C" evidence="2">
        <location>
            <begin position="459"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="667" mass="76493" checksum="A7AE65379EBFD976" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNR2</accession>
    <name>D7VNR2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arsenical-resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">arsB</name>
        <name evidence="5" type="ORF">HMPREF0766_12632</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993239.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12632"/>
    <dbReference type="EnsemblBacteria" id="EFK57559">
        <property type="protein sequence ID" value="EFK57559"/>
        <property type="gene ID" value="HMPREF0766_12632"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0798">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022869_0_0_10"/>
    <dbReference type="OrthoDB" id="1493959at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015103">
        <property type="term" value="F:inorganic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="PTHR43057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="342" mass="38273" checksum="5232A8A5AB8BAB53" modified="2010-10-05" version="1">MQPKLKFLDRYLTLWIFLAMAFGVGLGYFFPNISNVTDSLSVGTINIPLAIGLILMMYPPLAKVDYTVLPKAFKDKKVIGISLFLNWVIGTVMMFGLAVLFLRNEPDYMTGLILIGLARCIAMVIVWSDLAKANREYTALLVALNSVFQILSYSFLVWLFINVLPSKLGLANFNVNVSMKDVTESVLIYLGIPFFTGFVSRYVLIKSKGIEWYNRKYIPAVSPITLYALLFTIVLMFSLKGDKILELPVDVIKIAIPLIIYFVLMFFVSFFISKSLNVPYDRNASIAFTATGNNFELAIAVAIAVFGIHSPQAFVGVIGPLVEVPVLILLVRASLWLKKKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNW4</accession>
    <name>D7VNW4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <ecNumber evidence="5">3.1.6.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_12684</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.-" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993327.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12684"/>
    <dbReference type="EnsemblBacteria" id="EFK57611">
        <property type="protein sequence ID" value="EFK57611"/>
        <property type="gene ID" value="HMPREF0766_12684"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_10_4_10"/>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK57611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="512" mass="57642" checksum="22213537C5FEA6C4" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D7VNX6</accession>
    <name>D7VNX6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrogenase expression/synthesis hypA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hypA</name>
        <name evidence="4" type="ORF">HMPREF0766_12696</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993346.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12696"/>
    <dbReference type="EnsemblBacteria" id="EFK57623">
        <property type="protein sequence ID" value="EFK57623"/>
        <property type="gene ID" value="HMPREF0766_12696"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0375">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126929_5_0_10"/>
    <dbReference type="OrthoDB" id="1995603at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000688">
        <property type="entry name" value="HypA/HybF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34535">
        <property type="entry name" value="PTHR34535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01155">
        <property type="entry name" value="HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004761">
        <property type="entry name" value="Hydrgn_mat_HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0533">Nickel</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="117" mass="13684" checksum="6D53973994CF0307" modified="2010-10-05" version="1">MHETGIVQEIFDTLREEYPDRYQEIVRIRLEAGLLSNIQPILIQNAFEAYITGDTWFRNTELEVKVLPILAFCDNCKKSFEVVFHRFVCSCGITSDKVIQGEELRITQVTFKNNEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VP54</accession>
    <name>D7VP54_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993476.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12774"/>
    <dbReference type="EnsemblBacteria" id="EFK57701">
        <property type="protein sequence ID" value="EFK57701"/>
        <property type="gene ID" value="HMPREF0766_12774"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZXYX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134903_0_0_10"/>
    <dbReference type="OrthoDB" id="1927917at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="137" mass="15259" checksum="2F461590A9917D05" modified="2010-10-05" version="1">MLHLHSTLAIVLLLALVVSIIITLANFAGNKPYNRKIALIGLISAHLQLVVGLVLFFVLKYPSMISGSVMKDPTLRFKIIEHPLTMIIAIVLITIGYSKAKKITDAKKANQTVLIFFILGLIFILARIPWSTWSFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPA0</accession>
    <name>D7VPA0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_12820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993575.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12820"/>
    <dbReference type="EnsemblBacteria" id="EFK57747">
        <property type="protein sequence ID" value="EFK57747"/>
        <property type="gene ID" value="HMPREF0766_12820"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2911">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002997_0_0_10"/>
    <dbReference type="OrthoDB" id="141451at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007452">
        <property type="entry name" value="TamB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04357">
        <property type="entry name" value="TamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1712"/>
            <end position="1765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="1765" mass="197324" checksum="A5F3A58F0A84DF62" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPB2</accession>
    <name>D7VPB2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DEAD/DEAH box helicase</fullName>
            <ecNumber evidence="6">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rhlE2</name>
        <name evidence="6" type="ORF">HMPREF0766_12832</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="6"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993591.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12832"/>
    <dbReference type="EnsemblBacteria" id="EFK57759">
        <property type="protein sequence ID" value="EFK57759"/>
        <property type="gene ID" value="HMPREF0766_12832"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_28_3_10"/>
    <dbReference type="OrthoDB" id="643629at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="32"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="215"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK57759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="398" mass="45174" checksum="601BC00F96E32983" modified="2010-10-05" version="1">MNFQELNLSKLLIEKLNTFQIAEPTGIQKAVIPNILKGKDVLAISPTGTGKTEAFALPVLHLLTENKQSEHKTLILSPTRELAQQTYLRIKNCTPSEVNINTISIFGGQSYEKQASELSTDPAIVVATPGRLLDLMDQKLINLSVFKKVVIDEADEMLKLGFIAALFRIMGHLPAGRQTLLFSATFPKELEELVPKVLRQPFRFEVQNREAEQSQIHQYLLFVDKNDKKNLIKYLIDHYKIDAALIFTRTTHGVDRIVSDLQKHGLTAQGLYGDKSQAVRTAIVEDFKNRNFNFLVATDIASRGLHLDDLDHVINYEIPDTAEQYMHRIGRTARGTRDGYTYTFCDAEDNPNLIKLQIALKKNIPILSEHPYILSWQKMLAHKELKSNSKRKGSKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPC0</accession>
    <name>D7VPC0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993607.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12840"/>
    <dbReference type="EnsemblBacteria" id="EFK57767">
        <property type="protein sequence ID" value="EFK57767"/>
        <property type="gene ID" value="HMPREF0766_12840"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062241_0_0_10"/>
    <dbReference type="OrthoDB" id="1204218at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="287" mass="31509" checksum="906C10F7E0F18445" modified="2010-10-05" version="1">MIFVFLSVICSVLVAICIKWAKSRGINHLQLVLWNYPVALLMTWVFLNPGPVRWDNPILPWNLYLPLGILLPALFLIIALSIEYSGIVKTEVAQRLSLFIPLTAAFLLFGERIESGKITGLAVGVVAIICSIGWSKGGEKSGKPTSSIIYPAIVFIGMGCIDVLFKQVAQHKEIPYTASMLIIFALALLVACACLFYLLFWKKQKFDVQSMFGGLVLGVFNFGNIMFYMKAHRAIPENPSIVFTSMNIGVIAFGALAGIFLFNEKLSILNKAGLGLAVISVLLIAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPC9</accession>
    <name>D7VPC9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase, M24 family</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pepP</name>
        <name evidence="4" type="ORF">HMPREF0766_12849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993618.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12849"/>
    <dbReference type="EnsemblBacteria" id="EFK57776">
        <property type="protein sequence ID" value="EFK57776"/>
        <property type="gene ID" value="HMPREF0766_12849"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_1_2_10"/>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP_N" evidence="3">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="460" mass="52255" checksum="0E859FEC6DD8D13D" modified="2010-10-05" version="1">MFAAHTYQERRNVLKKNIGHGILLFLGNIENPINFEHNPYRFRQDSTFLYYFGIQEPRLAAIIDIDEDKTIVFGDELSIDDIVWMGKQETLKEKSLRSGISETRPFSALATYLQENKNRTVHYLPPYQPSNKILLTTLFSISVSAIQPSVPFITAVVKQREIKEEQEIKEIEEAIRVSTEMHLLAMRLVRPGIREFEIANAIQHLAADQSCEMAYPPIVTINGGILHNHYRQHTLKSGDLFLNDSGAETAMGYAGDLTRTFPADSRFTTKQKEIYNIVLQSFMNARNTLAPDTNFKDIHLKASLSLVEGLKSIGLMKGNAEEAVQAHAHTLFFQCGLGHMMGLDVHDMEDLGEQYVGYTPDEPKDTHTFGLKSLRLGKPLKAGHVVTVEPGIYFIPELIDIWQGENKNSAFINYDKVNEYRNFGGVRIEDDFLITADGYRLLGPELMKTAEEIENYRSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPI7</accession>
    <name>D7VPI7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="2">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">clpP</name>
        <name evidence="4" type="ORF">HMPREF0766_12907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993743.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12907"/>
    <dbReference type="MEROPS" id="S14.001"/>
    <dbReference type="EnsemblBacteria" id="EFK57834">
        <property type="protein sequence ID" value="EFK57834"/>
        <property type="gene ID" value="HMPREF0766_12907"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_3_1_10"/>
    <dbReference type="OrthoDB" id="1728970at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="232" mass="26022" checksum="9B79869EBFB04B0D" modified="2010-10-05" version="1">MNIDKNEFRKYAIKHHRIGSQHVDSFISRVQQNMPTNLTPYIVEERQLNVAQMDVFSRLMMDRIIFLGDAVTDQVANIIQAQLLFLQSTDAQRDIQIYINSPGGSVYAGLGIYDTMQYISPDVATICTGMAASMGAVLLVAGAKGKRAALKHSRVMIHQPSGGAQGVAADMEINLREMLKLKEELYTIIAEHSGQSYEWVEKSSDRDYWMRAAEAKEFGMVDEVLSSKKEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPL0</accession>
    <name>D7VPL0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rot</name>
        <name evidence="7" type="ORF">HMPREF0766_12930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993785.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12930"/>
    <dbReference type="EnsemblBacteria" id="EFK57857">
        <property type="protein sequence ID" value="EFK57857"/>
        <property type="gene ID" value="HMPREF0766_12930"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_16_4_10"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK57857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="152" mass="16550" checksum="733D01DABA3BD309" modified="2010-10-05" version="1">MSKAIIKTEKGDMTVEFYTADAPNTVDNFIKLAKSGYYDGLAFHRVIPDFVIQGGCPNSKEGAAGVPGTGGPGYKIDCELTGENQYHDRGVLSMAHAGRNTGGSQFFICHSRNNTAHLDRNHTCFGKVVENVDVVDDIRQGDRILTIEVIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPM0</accession>
    <name>D7VPM0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-demethylubiquinone-9 3-methyltransferase domain protein</fullName>
            <ecNumber evidence="2">2.1.1.64</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_12940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993796.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12940"/>
    <dbReference type="EnsemblBacteria" id="EFK57867">
        <property type="protein sequence ID" value="EFK57867"/>
        <property type="gene ID" value="HMPREF0766_12940"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3865">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_22_1_10"/>
    <dbReference type="OrthoDB" id="1889762at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008689">
        <property type="term" value="F:3-demethylubiquinone-9 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009725">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021700">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="27"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="162" mass="18483" checksum="57144725212B8B34" modified="2010-10-05" version="1">MSFFITNLILSAKVNELINPYGMKQMMYPCLWFEGNATEAVDFYISVFKDSRILSANPLVTFLEIKGQKFMALNGRPDFEPNQASSLVIECTSQDEIDHYWEAITKEGEESMCGWCKDKYGFSWQIIPENIEKLLFHSANAERAVQAMMGMKKIDIAALENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPN5</accession>
    <name>D7VPN5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_12955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993816.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_12955"/>
    <dbReference type="EnsemblBacteria" id="EFK57882">
        <property type="protein sequence ID" value="EFK57882"/>
        <property type="gene ID" value="HMPREF0766_12955"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2371343_0_0_10"/>
    <dbReference type="OrthoDB" id="2069268at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="95" mass="10330" checksum="8CEBAB78E7A3691B" modified="2010-10-05" version="1">MEDQNTPNFDPNQGQNPNQFNNPFNQQNQEDLSTGLKVLSFCIPLFGAIYYFIKKDEAPVQAKSACKFAIYGVVVGIILNIISMVLGGLGSVMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPT6</accession>
    <name>D7VPT6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000011">
        <property type="protein sequence ID" value="EFK57933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13006"/>
    <dbReference type="EnsemblBacteria" id="EFK57933">
        <property type="protein sequence ID" value="EFK57933"/>
        <property type="gene ID" value="HMPREF0766_13006"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3276836_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="41" mass="5041" checksum="83B7867678EA9298" modified="2010-10-05" version="1">MYSFCFMPEDMFVFIFCNKIVCQIRNVYPEHRGYAYTLTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VPY4</accession>
    <name>D7VPY4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0766_13038</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993946.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13038"/>
    <dbReference type="EnsemblBacteria" id="EFK55835">
        <property type="protein sequence ID" value="EFK55835"/>
        <property type="gene ID" value="HMPREF0766_13038"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030864_1_0_10"/>
    <dbReference type="OrthoDB" id="1536685at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041617">
        <property type="entry name" value="TPR_MalT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17874">
        <property type="entry name" value="TPR_MalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005672218" evidence="3">
        <location>
            <begin position="23"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="401"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="121"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFK55835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="515" mass="59672" checksum="17E4CA04A4DDAB0E" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ13</accession>
    <name>D7VQ13_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tat pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993986.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13067"/>
    <dbReference type="EnsemblBacteria" id="EFK55864">
        <property type="protein sequence ID" value="EFK55864"/>
        <property type="gene ID" value="HMPREF0766_13067"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050006_1_2_10"/>
    <dbReference type="OrthoDB" id="1007505at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026040">
        <property type="entry name" value="HyI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006241">
        <property type="entry name" value="HyI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="2">
        <location>
            <begin position="70"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK55864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="310" mass="34813" checksum="66D0EB5D40ABA70A" modified="2010-10-05" version="1">MKRSDFLRNAALVSGAALTGNALQASEQKAQNLFTEQKGKTFKLNYAPHQGMFQDSAGKNFLDEIQYFYDLGFRAIEDNGYLGRSVEEQEKIGNLLAKLGMTMGVFVVDGGQNWMTSLATGKPEFLDHFVKTCQRSVEAAKRCNAKWLTVVPGFYERKLPWGNQFANIVQAMRKGAEIFEPHNLIMVLETLSDTPDLFLQQTHETYAVCKAVNSPSCKILYDIYHMQRTEGDLLVNIDRCWDEIAYVQIGDNPGRKEPTTGEINYKNVFAHLYKKGYRGVMGMEHGKSKGGKAGEEALVAAYREVDSFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ26</accession>
    <name>D7VQ26_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002993999.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13080"/>
    <dbReference type="EnsemblBacteria" id="EFK55877">
        <property type="protein sequence ID" value="EFK55877"/>
        <property type="gene ID" value="HMPREF0766_13080"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1739371_0_0_10"/>
    <dbReference type="OrthoDB" id="1886963at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK55877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="150" mass="17681" checksum="89E7EFFABE7AC1E8" modified="2010-10-05" version="1">MRIKKFLLLFVVITGCAAQKKGDFELKDLVSAGYEFEKEGNTNRIDYLYADGDFSYRPEEYKLLKRKAEEKRAGLSRKEYALHSLYIYKKTDIINQHYGEGKEGLDGRNRDLIAYIRYNANKMDICYIIEEGNVVYDVVTDQRENFEFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ30</accession>
    <name>D7VQ30_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative flagellar protein FliS</fullName>
            <ecNumber evidence="8">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0766_13084</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the phytochrome family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="8"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994007.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13084"/>
    <dbReference type="EnsemblBacteria" id="EFK55881">
        <property type="protein sequence ID" value="EFK55881"/>
        <property type="gene ID" value="HMPREF0766_13084"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_50_1_10"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001294">
        <property type="entry name" value="Phytochrome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01033">
        <property type="entry name" value="PHYTOCHROME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0157">Chromophore</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PHYTOCHROME_2" evidence="6">
        <location>
            <begin position="134"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="510"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFK55881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="722" mass="83229" checksum="0533A2FDF6897EAB" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ32</accession>
    <name>D7VQ32_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucose/Sorbosone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bcd</name>
        <name evidence="4" type="ORF">HMPREF0766_13086</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994011.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13086"/>
    <dbReference type="EnsemblBacteria" id="EFK55883">
        <property type="protein sequence ID" value="EFK55883"/>
        <property type="gene ID" value="HMPREF0766_13086"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012253_1_1_10"/>
    <dbReference type="OrthoDB" id="567019at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107138" evidence="2">
        <location>
            <begin position="25"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="GSDH" evidence="3">
        <location>
            <begin position="78"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK55883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="412" mass="44665" checksum="A06EED68C9E1C932" modified="2010-10-05" version="1">MKTKLPLAYLLSGIALFSSCNSNAKNGEEVSGTDTTSYPSVEKNPANTDYKPAFAGQTRIKGVKTATAYEVKILSRDLKSPWGLVSLPDGRLLITEKEGTLRIATADGKLSEPITGLPPVDAKGQGGLLGIALDPSFASNRMVYWTFSHKVDGKNLTAVGKGKLADDEKSIQNAQIIYQATPAYNGTLHYGSRILFDKTGNIIFSTGERSDLETRPQAQDLKSALGKIIRITPEGKPAPGNPFEGNANARPEIYSYGHRNVQGLALHPETGDLWETEFGPKGGDEVNIVKPGKNYGWPTITYGLEYSGAKIGEAIQQKDGLEQPVYYYDPVISPSGITFYSSNTIPEWKNNLFIAALSGTHIARLVIKDNKVVGEERLLADQGQRFRAVIEGKNGELFAVTDAGWLVKVAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ33</accession>
    <name>D7VQ33_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994013.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13087"/>
    <dbReference type="EnsemblBacteria" id="EFK55884">
        <property type="protein sequence ID" value="EFK55884"/>
        <property type="gene ID" value="HMPREF0766_13087"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065741_0_0_10"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="56"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK55884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="268" mass="30772" checksum="8D35CC523CD7D5C1" modified="2010-10-05" version="1">MNKENNYIEINKTSWNTKTTVHINSDFYDVENFKKGKSSLNDIELQLLGDIKGKKILHLQCHFGQDTLSLARMGADVTGIDLSDKAIQVAQELAAELELTARFICSDVYELPQVLEEEFDIVYTSYGTIGWLPDLDKWASVVSKFLKPDGKFVFVEFHPFMWVWDDDFKYIQYSYFKDGAIIENVTGSYADREADITHETVSWNHALEEVFNSLIGQQLTVTSFNEYKYSPYSCFNNLVEIAPQQFQVKGMENKIPMVYSLTASKPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQ81</accession>
    <name>D7VQ81_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trehalose-6-phosphate synthase</fullName>
            <ecNumber evidence="7">2.4.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alpha,alpha-trehalose-phosphate synthase [UDP-forming]</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Osmoregulatory trehalose synthesis protein A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">UDP-glucose-glucosephosphate glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">otsB</name>
        <name evidence="14" type="ORF">HMPREF0766_13135</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="7"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK55932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13135"/>
    <dbReference type="EnsemblBacteria" id="EFK55932">
        <property type="protein sequence ID" value="EFK55932"/>
        <property type="gene ID" value="HMPREF0766_13135"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0380">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1877">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002351_3_3_10"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012766">
        <property type="entry name" value="Trehalose_OtsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="PTHR10788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02400">
        <property type="entry name" value="trehalose_OtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00018539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFK55932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="737" mass="85382" checksum="A733E96AFE9DBB01" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQH8</accession>
    <name>D7VQH8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994299.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13232"/>
    <dbReference type="EnsemblBacteria" id="EFK56029">
        <property type="protein sequence ID" value="EFK56029"/>
        <property type="gene ID" value="HMPREF0766_13232"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_2_10"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="192"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="291" mass="33811" checksum="EF2E73AD6A499925" modified="2010-10-05" version="1">MLLSINDFSEKYTFTQDTILLKPAEFAFVRLHALAEEIVAARNNFYMIILGIEGQGHATVSRHQFDIRPSSISIIPAETSYSLQHYSADFHAAVLVFDSDFIKKGFVRSEVMDELLYINPEYPPVFDLPEADYQDTLYKLNRIQHEIRLQSPFFPDIIRLYALQLLYDYNRICEICLLNSGTGLNRPFQILHEFRKLVEQHFKEWKTVKDYAEILHISPKYLSECVKGQLGVPAIHIIQQRIILESELLLNYGSLSIKEIAEELHFDTASHFSRYFKTAKGISPTEFRQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQI3</accession>
    <name>D7VQI3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994309.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13237"/>
    <dbReference type="EnsemblBacteria" id="EFK56034">
        <property type="protein sequence ID" value="EFK56034"/>
        <property type="gene ID" value="HMPREF0766_13237"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033A69">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_637612_0_0_10"/>
    <dbReference type="OrthoDB" id="2000016at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="434" mass="48743" checksum="8092B4933B9AF4C8" modified="2010-10-05" version="1">MKTKLVLIFSFLACLYGCRQDQLLELNPQTENSQSLKLDFEQKTGYNEKDIYFLNPNFRTSIKWSRIVWKSTDTAYIKVNVLDELSYPLGDTVISLQDQVWIKAFKNSSKEWRYLLLTFIPVETKKAFSGTIISSSILSNSTKIATFSKGENIKNLNQTNVTAIEKYNKSMGSLVKMAAGKKCVYAYVNGQLNQISCTDTDEIDDGDGGIYDDPPPNPGDYYPTNPPIGGGDTGEQKEEENIENNIENPCLKKIVDEVISNDIASLTNECLLDVFKQNDKINLRFYETTRLPDLTAGIASTTFTSGTSNLDVKIELNANTLPNASQEYVALAVVHESIHAYLYTKGFFTTMIDQHDMMWSSYIDVIAGYLNQQYGTDMNVARTLATDGLQNTFGSKILESTYTKLKLNTNYPAIRRAEIATQYRTGIKGKKCDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQI9</accession>
    <name>D7VQI9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase family protein</fullName>
            <ecNumber evidence="2">4.4.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gloA2</name>
        <name evidence="2" type="ORF">HMPREF0766_13243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994324.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13243"/>
    <dbReference type="EnsemblBacteria" id="EFK56040">
        <property type="protein sequence ID" value="EFK56040"/>
        <property type="gene ID" value="HMPREF0766_13243"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_16_0_10"/>
    <dbReference type="OrthoDB" id="2035522at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="129" mass="14974" checksum="09EDEFBD10DC6336" modified="2010-10-05" version="1">MKIEHLAIWVADLERMKNFYKEYFAAVAEDKYINEKKQYMAYFLQFSEGGTRLELMNRPDIFPATCRGIMEGLTHFAITVGSKEDVDSMTERLRRDGYTIYSEPRITGDGYYESVVLDPEGNHLELIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQK9</accession>
    <name>D7VQK9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_13263</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994366.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13263"/>
    <dbReference type="EnsemblBacteria" id="EFK56060">
        <property type="protein sequence ID" value="EFK56060"/>
        <property type="gene ID" value="HMPREF0766_13263"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_0_0_10"/>
    <dbReference type="OrthoDB" id="248533at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="112"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="392"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="620" mass="70131" checksum="145B28B2106E9004" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQN8</accession>
    <name>D7VQN8_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pobR</name>
        <name evidence="2" type="ORF">HMPREF0766_13292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994407.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13292"/>
    <dbReference type="EnsemblBacteria" id="EFK56089">
        <property type="protein sequence ID" value="EFK56089"/>
        <property type="gene ID" value="HMPREF0766_13292"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2001395_0_0_10"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="135" mass="15842" checksum="9AD39A0CF5CBE52A" modified="2010-10-05" version="1">MDTSTKTPQRQQELTAIFMNELDKHLDDLLQGRISDMYEIRDIADHMHIHPRHLSNTIKRTTGRSACSFFEEKIIQQAKILLAQPGRSIQEIAILLTYDPSNFTKFFKRFTQITPKQYRNQILEEETIKSKNSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQQ9</accession>
    <name>D7VQQ9_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994436.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13313"/>
    <dbReference type="EnsemblBacteria" id="EFK56110">
        <property type="protein sequence ID" value="EFK56110"/>
        <property type="gene ID" value="HMPREF0766_13313"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_591514_0_0_10"/>
    <dbReference type="OrthoDB" id="909088at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMPK1_CBM" evidence="1">
        <location>
            <begin position="384"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="461" mass="53496" checksum="FB2FC46A059E5A40" modified="2010-10-05" version="1">MKRAIVILIGILFSQYVPVLSCTIFIAHDEKQVLVGNNEDYSPLKKTYIWVRPSVQQKKGYIFWGFEEKFPEGGINDQGLFYDAAALPQEVAIIKDLSKPDFEGYILEKILQECGSVEEALKLFAQYNLTWQQKAQIMIADRTGDYAIVHANYIIRPGSKNYVLTNYSLQDPQYSDFKCWRRKTAYNLLQTKALSFENFTNILDATAQRETDNSTVYSQVCDLKNKTIYLYQRHDYTVVSKIDILQLLKKGYQDIEIKDLFPKSLAERIEQTYNRQGIAAAISMYNKQRKSNKMHYQFSERDLEKFGYQLIDSNRITDAEKLFETNLKYYPLSENAIAALANACLLSGKKEKANRLYDQVRKINPSNYYLNLFGPQKNSITFRIKGMQGAETIALTGTFNNYDPHANPFIKKDGEWICTLPVAPGKYAYKIYVDNTYWMQDPGNMMHTKPNEWWDSYLQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VQY1</accession>
    <name>D7VQY1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994524.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13385"/>
    <dbReference type="EnsemblBacteria" id="EFK56182">
        <property type="protein sequence ID" value="EFK56182"/>
        <property type="gene ID" value="HMPREF0766_13385"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1132387_0_0_10"/>
    <dbReference type="OrthoDB" id="1231841at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018644">
        <property type="entry name" value="DUF2071"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09844">
        <property type="entry name" value="DUF2071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="244" mass="28507" checksum="109B8A09DC5213DE" modified="2010-10-05" version="1">MEFLKNHPFAVEAFFDSSVVLTFALPRQQLQKFIPDCLELDLFEDKWAFIAVALVRTSSLRPKGFPSFMGHDFFLIGYRIFVRYSNANGKKYRGLYILKSETDKKKMEYLGNIFTHYNYSTTDISQVNTDDFSSVSSKKSGFEIQIIRSKEDVQIPKGSVFSDWKDARKFAGPLPFTFTYNVTNKKVLIIEGVRQNWKPSPIQICTYHFDFFKHLNLDSPILSSAFEIKNVPYYWKKGRTETWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRE0</accession>
    <name>D7VRE0_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_13544</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994730.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13544"/>
    <dbReference type="EnsemblBacteria" id="EFK56341">
        <property type="protein sequence ID" value="EFK56341"/>
        <property type="gene ID" value="HMPREF0766_13544"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_10"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="124"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="124"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK56341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="224" mass="25333" checksum="36B007F91217EA02" modified="2010-10-05" version="1">MKILIIEDEYELAKSIADYLGQQGYRCEFASTFQMAQEKIAGFDYDCILLDIMLPDGNGMHVLQTLKEQEKQDGVIIISAKDALDDKIKGLQIGADDYLTKPFHLSELVARIYAVIRRKQFQNSNIIVQNELQIDLLAKTVSVGDHAVPFTKKELDLLLYFIGNKNKVISKSTLAEHLSGDVADMLDNHDFIYAHIKNLKKKLQDAHSGSYLKTIYGSGYKWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRI3</accession>
    <name>D7VRI3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_13587</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002994783.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56384">
        <property type="protein sequence ID" value="EFK56384"/>
        <property type="gene ID" value="HMPREF0766_13587"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2989">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020360_3_1_10"/>
    <dbReference type="OrthoDB" id="975147at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045380">
        <property type="entry name" value="LD_TPept_scaffold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20142">
        <property type="entry name" value="Scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107836" evidence="3">
        <location>
            <begin position="23"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Scaffold" evidence="5">
        <location>
            <begin position="91"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="242"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK56384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="488" mass="56221" checksum="E17C19EFF74FA3DF" modified="2010-10-05" version="1">MRKIQFGIFLLLVLWFISSCNTDREETFGDELAKVFQQKGYRNFDTTAYLAVFKQELSKNKSQLHNPKWVTEFADSTSGMTFISRNLSRGIVDTLCMYLEQSDKHGLSAAYFHTNQIKESFDKLNTVKSGKVEDIYPLLAKLDLLATDGYITYISILRGGAVNPKQLYGRYFEKMHKVTKQEARRVLDSTDVKEYLADIQPKNSYYLKLQELLQKGGLNKEDKENICLTLEKLRWMGKDFPEKYVVVNIPEQKLRMVDNRKTKDVMNVCVGETIYGPYARRAGATDNHETPVLSGELDRMQVNPVWNIPVSIVKKELISSLRSNPNYLESRNMVAYNKKGQMVDPNTVDWSSDSVLNFKFKQNPGADNSLGNIKFIFSNPYSIYLHDTPAKQMFSAKNRAVSHGCVRVERPAALAAFLVNDDKKAEQIATEIADTLNKSRWVMMKKTIPVYITYYTTWVDDDGKLYRLPDIYGYDERLKKAMKKYYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VRW4</accession>
    <name>D7VRW4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative phosphate ABC transporter, permease protein PstA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pstA</name>
        <name evidence="6" type="ORF">HMPREF0766_13718</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995093.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13718"/>
    <dbReference type="EnsemblBacteria" id="EFK56515">
        <property type="protein sequence ID" value="EFK56515"/>
        <property type="gene ID" value="HMPREF0766_13718"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_2_2_10"/>
    <dbReference type="OrthoDB" id="1763210at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="69"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK56515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="284" mass="30757" checksum="2989190A5C12E2D5" modified="2010-10-05" version="1">MANVKTRLFKEQVAKTLMRLSGMAVTGSLFFILGTILYKGLPYISWDMITQVPKGGFYIGKEGGILNAILGSLYLAGAATLLSTLIGIPIAIYLNIYVRSGSKLAQLSKLLFDVLFGIPSIVYGAVAFSLMVWLGIRASLLGGIITITLLTIPIVVRTVDELIKTIPGDLKHVTLSLGTTRWEVAKIFIRYIRPGILTAILLAFGRSIGDVAGVLLTTGFSDNLPKYIDEPAATLPLAIFFQLSSPIPEVQGRAYASALILSLIILIIVLCTHILQSKQKKHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS31</accession>
    <name>D7VS31_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter, CPA2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_13785</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995260.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13785"/>
    <dbReference type="EnsemblBacteria" id="EFK56582">
        <property type="protein sequence ID" value="EFK56582"/>
        <property type="gene ID" value="HMPREF0766_13785"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017738_0_0_10"/>
    <dbReference type="OrthoDB" id="941006at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="24"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFK56582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="709" mass="78620" checksum="A982BEC7B6A293FF" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D7VS63</accession>
    <name>D7VS63_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclophil_like2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_13817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995334.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13817"/>
    <dbReference type="EnsemblBacteria" id="EFK56614">
        <property type="protein sequence ID" value="EFK56614"/>
        <property type="gene ID" value="HMPREF0766_13817"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4925">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099043_0_0_10"/>
    <dbReference type="OrthoDB" id="1961657at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041183">
        <property type="entry name" value="Cyclophilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18050">
        <property type="entry name" value="Cyclophil_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107314" description="Cyclophil_like2 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclophil_like2" evidence="2">
        <location>
            <begin position="48"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK56614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="158" mass="17202" checksum="9D4A97B8D061C8AE" modified="2010-10-05" version="1">MKHSFLMVVAFMTMLVCSASSCDKNDNNSNTNNNPENTTPIANGKIKIKVGSQTFTATLLDNNSVKAFKEMLPLTINMVDLNNNEKYYDLPNSLPTNPSNPGTIKNGDLMLYGSKTLVLFYKTFSTSYSYTKLGALDDVTGLASALGSGNVTVTFEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSF1</accession>
    <name>D7VSF1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Curlin associated repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_13905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995543.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13905"/>
    <dbReference type="EnsemblBacteria" id="EFK56702">
        <property type="protein sequence ID" value="EFK56702"/>
        <property type="gene ID" value="HMPREF0766_13905"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030D2R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_821124_0_0_10"/>
    <dbReference type="OrthoDB" id="951234at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107624" evidence="1">
        <location>
            <begin position="20"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="338" mass="34830" checksum="ECA3EF1ACB212C99" modified="2010-10-05" version="1">MRKLLITACALTSVSFAAAQGNQDYTTQTGIANNAQVTQVGLQNHNTIYQLGAQNLAKTNQNGSNNKNESNSIGLGNSIDVTQLGASNSNITNQLGITNTATVNQDGSSNIGRQNQIGMSNNAATDQNGFLNISAQNQLGFSNTATVDQDGSLNLTVQNQIGMGNTAASIQNGIANLTVQTQLGSNNGAYANQTGALNATIQTQSGDGQSAQSMQNGVANLALQTQSGTNNGAAITQDGIANASIQTQNGDANNATSVQDGFLNLNLQDQSGNGNIAVASQTGSLNLISQSQTGNTNSAFDFQTGIANSSYVTQLGDQNYHMGIQTGMGNMMTIFQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSG5</accession>
    <name>D7VSG5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma factor regulatory protein, FecR/PupR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995569.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13919"/>
    <dbReference type="EnsemblBacteria" id="EFK56716">
        <property type="protein sequence ID" value="EFK56716"/>
        <property type="gene ID" value="HMPREF0766_13919"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050192_1_0_10"/>
    <dbReference type="OrthoDB" id="1381035at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032508">
        <property type="entry name" value="FecR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16344">
        <property type="entry name" value="DUF4974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="150"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4974" evidence="3">
        <location>
            <begin position="292"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="364" mass="41690" checksum="0CE3365C92E9383C" modified="2010-10-05" version="1">MDNKEFYKQLVQRYHSGKANEQEIALFLELLRTGQIDDIVKWHMEEQSGIETKKTQRTRYYHLLKYAAALLLLTLTGAALLYNWYERERKIEVALMNNIGPAISKATLKLADGRHIMLDSTFGELIIQDSIIRDQSGKMVHQGENEYYEVHVPKGGTFHLSLSDGSKVWLNSGSTLRFPQKFAGNLRKIELKGEAFFEVRKQYAADGERIPFVVHTLKQTVEVLGTSFNVKAYGEENESATLFTGLVRLKNNTNNHEKMLSPGTKAVLERNGEFKVGIADLEEEASWRSDAFLFNETPINDILNQLSRWYNVDMEFTGSAEYKFNGYLQRNVSLGDALETLKGTGELDYQYQNHKVIIKQKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSI1</accession>
    <name>D7VSI1_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H quinone oxidoreductase, PIG3 family</fullName>
            <ecNumber evidence="2">1.6.5.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cryZ</name>
        <name evidence="2" type="ORF">HMPREF0766_13935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995588.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13935"/>
    <dbReference type="EnsemblBacteria" id="EFK56732">
        <property type="protein sequence ID" value="EFK56732"/>
        <property type="gene ID" value="HMPREF0766_13935"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_10"/>
    <dbReference type="OrthoDB" id="1027479at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:NADPH:quinone reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK56732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="322" mass="34588" checksum="A2FBE6330201799E" modified="2010-10-05" version="1">MKAVVISSSGGPEVLKVEDRPVPVVGDQEVLIRVKAAGINRPDVFQRKGNYPAPAGVVADIPGLEISGVIEATGSMAGSWKAGDEVLALIAGGGYAEYAVVDAGSCMLKPENLSYEEAAALPETVFTVWHNLFERGQLKKGERVLIHGGSGGIGSTAIQLAALSGAEVYATAGSREKCEFCESLGAVRAINYHEEDFEEVLKESGVDVILDCIGGDYFNKNIAILNPDGRLVYINAMEGAKVQLNILQMMQKRLAITGSTLRARDKSFKAELTASVVGNVFPFIESKAFKPMLFKSFDFTQAEQAHRLMEEGHFLGKLVLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSL5</accession>
    <name>D7VSL5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_13969</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995632.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_13969"/>
    <dbReference type="EnsemblBacteria" id="EFK56766">
        <property type="protein sequence ID" value="EFK56766"/>
        <property type="gene ID" value="HMPREF0766_13969"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_2_1_10"/>
    <dbReference type="OrthoDB" id="1579676at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="63"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="95"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="379" mass="42224" checksum="49550B32AAA22C22" modified="2010-10-05" version="1">MKPNFIRSLIFSSLAIVLYSCQESQSSESSKDEISVIPTTTVIRLDTTITQDYVTDIQAVKNVELRSRLNGFLEKIYVDEGDFVRKGQILFTLNAEEFRTELAKANAMLNNAIADAKKASLEADQTRILLQKNIISKTEMDLAKAKLQAAESKIDEARSLVQFAKTRLNQCSIRAPFDGNIDRILLREGSLLTEGSLLTTISDNKQVYAYFDITEQQFLTMAADSSSSNTFKTPVQLTLANGEIYPLSGVAELAETEFNNETGTISLRAKFSNPNKTLRHGASGNINFPIRMDNIIAVHQKAVFEIQDRTFVYTVGKDNTIKMTSFIPGPRIGHYYVVTSGLDQDQQVVYEGTQGLKDGSIIQPQLISEEKNKLAHNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSL7</accession>
    <name>D7VSL7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_13971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56768">
        <property type="protein sequence ID" value="EFK56768"/>
        <property type="gene ID" value="HMPREF0766_13971"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2994412_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="57" mass="6385" checksum="D8CDB318125899B4" modified="2010-10-05" version="1">MEAGNFFLFCILTELSGNGTALFFYSSEQNQPADCSGDILYLRLQNVQTNGIQAYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D7VSY7</accession>
    <name>D7VSY7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002995885.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK56888">
        <property type="protein sequence ID" value="EFK56888"/>
        <property type="gene ID" value="HMPREF0766_14091"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_645426_0_0_10"/>
    <dbReference type="OrthoDB" id="1588560at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK56888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="425" mass="47824" checksum="43E99B64D31FB15C" modified="2010-10-05" version="1">MNYNIVMGTDNKTLNPIVQQIYQKIYPHIFKGSKDIATELFLAVFYDINEPPVIDLSQSVQLKKEDFQNHYTSELSEEELFLDVQEEALILDMLSKATFQAYFPNINLKLKLKDTSLLNINIKVSAKVNIQTSIEDKQNYLGASILTADLEIKDVEDYKEYIDELKKHILPLLIHVLNKDLLDKIKLPALTFKDVTISLPIPVVEKSFVTAYSCIGARQPDTYAPLNWPVETVFAGVDSTAIETMAAIPFPLKKENEFSWKIISGHVLAQVFNPRSFVIQSDGSIEGKIDTELLAQLTLKKGFFKISFGPHGKATIKATFKPVVHNGRLLLTVKNLNIPKLDIDFGIAKWAEYLLKPLSYGLSLALNEIFLPLVSAILRQVEIPIMYFPTISFEIKGMTFNIDITEAKTSKLDKLLLISGIPSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT53</accession>
    <name>D7VT53_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mercuric transport protein MerT</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Mercury ion transport protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HMPREF0766_14157</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MerT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002978464.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14157"/>
    <dbReference type="EnsemblBacteria" id="EFK56954">
        <property type="protein sequence ID" value="EFK56954"/>
        <property type="gene ID" value="HMPREF0766_14157"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118124_0_0_10"/>
    <dbReference type="OrthoDB" id="1345632at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015097">
        <property type="term" value="F:mercury ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003457">
        <property type="entry name" value="Transprt_MerT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02411">
        <property type="entry name" value="MerT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0475">Mercuric resistance</keyword>
    <keyword evidence="11" id="KW-0476">Mercury</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="16">
        <location>
            <begin position="129"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFK56954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="197" mass="21661" checksum="39C761EDC595104B" modified="2010-10-05" version="1">MKTDKKLIGAGLLTTIAASLCCITPVLALIAGTSGLASTFSWLEPFRPYFIGLTILVLGFAWYQKLKPKKQIDCNCETEEKPKFIQSKMFLGIVTAFAIVMLAFPYYSSIFYPKTEKQIIAVDKSNIQKVEFTISGMTCASCGEHVNHEVNKLTGIISSNASYEKGNAIVEFDNSKTNISEVEKAINSTGYSVTDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT58</accession>
    <name>D7VT58_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HlyD_D23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_14162</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002978452.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14162"/>
    <dbReference type="EnsemblBacteria" id="EFK56959">
        <property type="protein sequence ID" value="EFK56959"/>
        <property type="gene ID" value="HMPREF0766_14162"/>
    </dbReference>
    <dbReference type="GeneID" id="66690339"/>
    <dbReference type="eggNOG" id="COG1566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_6_3_10"/>
    <dbReference type="OrthoDB" id="1174564at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107557" description="HlyD_D23 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="35"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK56959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="300" mass="32893" checksum="3B8B761BD0CE13F5" modified="2010-10-05" version="1">MYKIKTIALIASIATVLTACNNNKVSFDASGSFEAEETIISSEATGTIKQFSIEEGQTLEAGQTIGYIDSLQLYLKKKQLEAQVTAILGKKPNIPVQLSALQEQLRTAERERTRVANLVKGDAATPKQLDDINAQIEVLKKQIEAQKSTLSISSEGLGKDVVPLQVQIEQLNDQLAKCYIINPASGTVLSKYAEANEMTSAGKPLYKIANLSNIILRVYITGDQLPQAKLNQTVKVLTDDGKGGYKETAGTIIWINDKAEFTPKTIQTKDERANMVYAVKIKVKNDGLYKVGMYGEIKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D7VT76</accession>
    <name>D7VT76_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_14180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK56977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996096.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14180"/>
    <dbReference type="EnsemblBacteria" id="EFK56977">
        <property type="protein sequence ID" value="EFK56977"/>
        <property type="gene ID" value="HMPREF0766_14180"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1435">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015553_0_3_10"/>
    <dbReference type="OrthoDB" id="113583at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="25"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="289"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK56977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="544" mass="61927" checksum="1B5DFA214D53072C" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTE2</accession>
    <name>D7VTE2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996280.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK57043">
        <property type="protein sequence ID" value="EFK57043"/>
        <property type="gene ID" value="HMPREF0766_14246"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_798821_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="355" mass="40825" checksum="E7E07BA579B3F60F" modified="2010-10-05" version="1">MSIYQNNDCFGRNIVKSYAVTQEVEASFKFIESGILNLQAQKFAVLNNHVTLQLLAAGFERLLKILLLLKEKELNGDFPELELAKKQFNKYNGGHGIGKMLDELLEYSEGVEEMKNIPMIEEDIRFLKEDEKFTILIDILTEFAISQRYFYIDTIVLNKENTASNPFEKFTSFVYSFNKNIDTDNLSYEEEDKLAIKNSIICIEMGVRAISSFFTHGLGDLGRQYYGDFSSFILLKEKDLGSLDYTKSRVAPHELYVPMSKYSLKFLGLKMDSKSKLIVSSEYEDWPFSVGSIKVYFTGSRYYFAEIGNKIFALTGATSRDYEIPTYFKSKKLKPKGYALFLLEEAKKLNPKEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTF5</accession>
    <name>D7VTF5_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0766_14259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996318.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14259"/>
    <dbReference type="EnsemblBacteria" id="EFK57056">
        <property type="protein sequence ID" value="EFK57056"/>
        <property type="gene ID" value="HMPREF0766_14259"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029016_4_1_10"/>
    <dbReference type="OrthoDB" id="1677960at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="118"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK57056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="401" mass="46053" checksum="D586E9CC02C8E534" modified="2010-10-05" version="1">MRTFVCLSSYYKGYDFMDECKKLGNKVILITSESLKDKNWPWHAIDEVYYMPETEPSVWNSDHMIQGFAYLMRIHIIDTVIALDDFDVEKAALIRETFRIQGMGQTTYRYFRDKLAMRQMAKDNGIHIPSFVPVFNDAVIAKFIEENPAPWVLKPRSEASASGIRKIHSTDALWQALDELGAERIHFLLEVFKPGDVFHVDCLVYDKEIKFISCSRYLSPPMAVSHEGGIFRTKTLGEDSEDFKQLEEINHQVLSKFGIVHGATHSEFIKSNEDGKFYFLETSCRVGGAHIADMVEAATHVNLWREWVKIETMVLNKSTYHLNYKRKYFAGLIIALAKDKYPDIIDFRVAELVKSLDLEHHISLLYQSDSAEKISEALDSAAEKIYTHHLSILPPQAKPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTH5</accession>
    <name>D7VTH5_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_14279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996374.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14279"/>
    <dbReference type="EnsemblBacteria" id="EFK57076">
        <property type="protein sequence ID" value="EFK57076"/>
        <property type="gene ID" value="HMPREF0766_14279"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117112_1_0_10"/>
    <dbReference type="OrthoDB" id="1390922at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK57076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="149" mass="17689" checksum="49A0A009E32FA2F2" modified="2010-10-05" version="1">MQIISVRENPEYKDTAIRYLQQSWPDISPVIYEDCIAHSIHAQQELPQWYLLEKDEKVIGCAGLISNDFISRMDLYPWICAIYIAEEHRGHAYATLLIDKAKEDARKFGFRYLNLSTDHIGYYEKYGFQYIGQGYHPWEEESRIYQIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTI3</accession>
    <name>D7VTI3_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0766_14287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996386.1">
        <property type="nucleotide sequence ID" value="NZ_GL379770.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14287"/>
    <dbReference type="EnsemblBacteria" id="EFK57084">
        <property type="protein sequence ID" value="EFK57084"/>
        <property type="gene ID" value="HMPREF0766_14287"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8GX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047565_1_0_10"/>
    <dbReference type="OrthoDB" id="384212at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011486">
        <property type="entry name" value="BBP2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07642">
        <property type="entry name" value="BBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFK57084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="351" mass="38918" checksum="03439F748D2F522B" modified="2010-10-05" version="1">MKKLITLSIIYHLFLNLTNAQEEKSTLLGLEISGSVDTYWKYDFQNQPNIKTYFTEDNNSVSIGMVDLALKKKTGRASFVGELSFGPRGQYRSILNGDGQAGDDNNSFHIQNLYVSYDLTEKLSMTAGFMGTFVGYEVICPSNNFHYSTSYLFGAGPFQDAGLKANYTFSEKVALMVGIFNDWNVYQDFNGVSHFGSQLSIIPNEASSFYLNFLTGSSVGGVANYSSGTLLDLVGNYSFSPRFTLGLNATNYNQKGDAGYSGIALYPRVNINENIGIGVRGEYFKTKDAPLLAIEENEIWSATLSGHLRHQGFSFIPEVRFDNSKNEMFVKKDLSPTKNAGQFSMALVYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTL2</accession>
    <name>D7VTL2_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative alpha-1,2-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_14316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000012">
        <property type="protein sequence ID" value="EFK57113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14316"/>
    <dbReference type="EnsemblBacteria" id="EFK57113">
        <property type="protein sequence ID" value="EFK57113"/>
        <property type="gene ID" value="HMPREF0766_14316"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003690_2_2_10"/>
    <dbReference type="OrthoDB" id="100818at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_92N" evidence="3">
        <location>
            <begin position="43"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92" evidence="2">
        <location>
            <begin position="260"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK57113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="697" mass="78816" checksum="6BF0FB9C389FCF1E" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTL7</accession>
    <name>D7VTL7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Resolvase, N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0766_14337</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000013">
        <property type="protein sequence ID" value="EFK55776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001621.1">
        <property type="nucleotide sequence ID" value="NZ_GL379777.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK55776">
        <property type="protein sequence ID" value="EFK55776"/>
        <property type="gene ID" value="HMPREF0766_14337"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010686_3_0_10"/>
    <dbReference type="OrthoDB" id="1791095at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="6">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="4 5">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFK55776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="202" mass="23146" checksum="7FD3C32B026F18FC" modified="2010-10-05" version="1">MIYGYIRVSTDKQTVENQRYELNQFCEKNVLVVNKWIEETISGSKNLHDRKLGKLLKKMKKGDILICSELSRLGRNLLMIMGILNECMNRDIQVWTIKDNYRLGSDINSKVLAFAFGLSAEIERNLISQRTKEALARKRAEGVVLGRPKGRKSSKTKLTGQEKKIQELLDKKVSYSAIGRILGVHRLTVSSFVKEQDMQSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D7VTX0</accession>
    <name>D7VTX0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Large-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">mscL</name>
        <name evidence="10" type="ORF">HMPREF0766_14440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MscL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000014">
        <property type="protein sequence ID" value="EFK55749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003002286.1">
        <property type="nucleotide sequence ID" value="NZ_GL379780.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14440"/>
    <dbReference type="EnsemblBacteria" id="EFK55749">
        <property type="protein sequence ID" value="EFK55749"/>
        <property type="gene ID" value="HMPREF0766_14440"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1970">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095787_0_0_10"/>
    <dbReference type="OrthoDB" id="1863650at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00115">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01264">
        <property type="entry name" value="MECHCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFK55749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="135" mass="14650" checksum="5D682B905B44159C" modified="2010-10-05" version="1">MGFIKEFKEFAMRGSVVDLAVGVVIGGAFGKIVTSLVDDIIMPPIGFITGGIDFSDMKYVLTAGDEANKIKEVAINYGNFINIVIQFLIVAFCIFLVIKGLNSLKRKDEPAPAAAPAPTKEETLLTEIRDILKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D7VU02</accession>
    <name>D7VU02_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0766_14472</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000015">
        <property type="protein sequence ID" value="EFK55697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_14472"/>
    <dbReference type="EnsemblBacteria" id="EFK55697">
        <property type="protein sequence ID" value="EFK55697"/>
        <property type="gene ID" value="HMPREF0766_14472"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0827">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002539_1_1_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011639">
        <property type="entry name" value="RM_methylase_Eco57I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07669">
        <property type="entry name" value="Eco57I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Eco57I" evidence="3">
        <location>
            <begin position="700"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK55697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="833" mass="96901" checksum="168C36C2D84A584B" modified="2010-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGC7</accession>
    <name>D7VGC7_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FecR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003001934.1">
        <property type="nucleotide sequence ID" value="NZ_GL379778.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10046"/>
    <dbReference type="EnsemblBacteria" id="EFK60102">
        <property type="protein sequence ID" value="EFK60102"/>
        <property type="gene ID" value="HMPREF0766_10046"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050192_2_0_10"/>
    <dbReference type="OrthoDB" id="1381035at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FecR" evidence="1">
        <location>
            <begin position="127"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="355" mass="40690" checksum="8DE919F34442BA7D" modified="2010-10-05" version="1">MNISRELINKFLRGQCTPEEHAFVRAYLEEHGEDAAAFFPEEEWTEWSEDNSYDESRQDEIFQLIVQQLQEEEVQPRLYLSFLYRVAAAAILLLVCALGERATRHDQAPLITGIQREIPTLYRINASNQPMNIVMSDSSSVLLYPNAELRYAENFKWKNKREIWLVGKAKFSVHKDKTKPFMVYSDRLVTTALGTQFIVDAPRQAKHVAIRLLEGSIRVEDYQEKINGQYISQILRPGEEVNIQLSTLSLLADVLKKAPVSPDQRNASAVSKPEELAFKNKKLAEVLSEIDKAYGTDTRWSIAGIEKLHFSGRYERNADNYRVILNDIAVLHHLILKIDDNGKGAQLKQEINKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGG4</accession>
    <name>D7VGG4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0766_10083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000001">
        <property type="protein sequence ID" value="EFK60139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFK60139">
        <property type="protein sequence ID" value="EFK60139"/>
        <property type="gene ID" value="HMPREF0766_10083"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2169476_0_0_10"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK60139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="110" mass="12098" checksum="9F28AEFA2FF63D42" modified="2010-10-05" version="1">MEPKALEGWTRGLFYIMFIIGGLSPQPVWDYNAHYVIKPGKKDAGHKSLPEGRRLCTSFASAVGQALWGMATLLSIFIKRSCSMNPMGLHSKGAKSVSGILLHWGALDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGK4</accession>
    <name>D7VGK4_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trigger factor</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tig</name>
        <name evidence="2" type="ORF">HMPREF0766_10123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996637.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10123"/>
    <dbReference type="EnsemblBacteria" id="EFK59206">
        <property type="protein sequence ID" value="EFK59206"/>
        <property type="gene ID" value="HMPREF0766_10123"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045516_0_0_10"/>
    <dbReference type="OrthoDB" id="932993at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003095">
        <property type="entry name" value="Trigger_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="SSF102735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trigger_N" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFK59206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="441" mass="50963" checksum="A36C289D4006A876" modified="2010-10-05" version="1">MKVSHKKIDDINANITVDLAPEDYNPQVDKAIKDQAKKAKLPGFRPGMVPTGHIRRTYGKSILFDEVNKVVNDKIAEYISENKLEVLGQPLPIDEEVNYNWDFKDSFNFTYEIGLAPEFETPFTKETEFTEYDIKADTETLESRIKNLRRSYGKMTNPEVSEEGDVLYATLKQEGEEGIEKTTSVRTDIIEDAKIKKSLSGLKKDDSVKIDVKKAFKAADLARILGITEEEAEAIAPAKFELTVKNINRLEESELNQEFFDKLFPAGEVTTEEVFKEKVTEEVENLFKQNSAQKLRNDLYTFGMEKVDVKFPEEFLKRWLKATNPNITEQELEEGFADFINNLKWTIIENRIVTANNLEVKYDEVINLAKERIYAQIKMYNINEEPADEQLSQYAIQMLQDREQANRLFEEAKALKVFDHLKTVVKLKSKKIDYDKFEKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGL6</accession>
    <name>D7VGL6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tex-like protein N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhgF</name>
        <name evidence="3" type="ORF">HMPREF0766_10135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996673.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10135"/>
    <dbReference type="EnsemblBacteria" id="EFK59218">
        <property type="protein sequence ID" value="EFK59218"/>
        <property type="gene ID" value="HMPREF0766_10135"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009833_0_2_10"/>
    <dbReference type="OrthoDB" id="120764at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05685">
        <property type="entry name" value="S1_Tex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044146">
        <property type="entry name" value="S1_Tex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="636"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFK59218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="745" mass="82657" checksum="AC00DFF296145F2F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGR6</accession>
    <name>D7VGR6_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative azurin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">azu</name>
        <name evidence="4" type="ORF">HMPREF0766_10185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996814.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10185"/>
    <dbReference type="EnsemblBacteria" id="EFK59268">
        <property type="protein sequence ID" value="EFK59268"/>
        <property type="gene ID" value="HMPREF0766_10185"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3241">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112845_0_0_10"/>
    <dbReference type="OrthoDB" id="1735306at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13922">
        <property type="entry name" value="Azurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014068">
        <property type="entry name" value="Azurin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028871">
        <property type="entry name" value="BlueCu_1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00196">
        <property type="entry name" value="COPPER_BLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003107170" evidence="2">
        <location>
            <begin position="21"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Copper-bind" evidence="3">
        <location>
            <begin position="59"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFK59268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="177" mass="18691" checksum="6FE2307484AF8639" modified="2010-10-05" version="1">MKKLFIIPALALAVAFTSCGGESKKTSTEGNTETTSTETQTPEETVPGIENVAISNTLSLEGNDQMKYDKDLFRVKAGEPVELTFKNAGQQPKESMGHNVVILKPGTDVATFGGEAAGAAASEYIPKSSASSIIAHTKLLGPGETDKITFTLEKGVYSFICSFPGHFGIMQGKIVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGS0</accession>
    <name>D7VGS0_SPHSI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">lpdA</name>
        <name evidence="16" type="ORF">HMPREF0766_10189</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
                <person name="Reid J."/>
                <person name="Worley K."/>
                <person name="Petrosino J."/>
                <person name="Highlander S."/>
                <person name="Gibbs R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 33861</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="ACHA02000002">
        <property type="protein sequence ID" value="EFK59272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002996822.1">
        <property type="nucleotide sequence ID" value="NZ_GL379771.1"/>
    </dbReference>
    <dbReference type="STRING" id="525373.HMPREF0766_10189"/>
    <dbReference type="EnsemblBacteria" id="EFK59272">
        <property type="protein sequence ID" value="EFK59272"/>
        <property type="gene ID" value="HMPREF0766_10189"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_2_10"/>
    <dbReference type="OrthoDB" id="267896at2"/>
    <dbReference type="Proteomes" id="UP000006258">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="3"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="343"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="178"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="40"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFK59272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006258"/>
        </source>
    </evidence>
    <sequence length="462" mass="49253" checksum="875B867020A12B18" modified="2010-10-05" version="1">MNYDIIVIGSGPGGYVAAIRAAQLGFKTAIVERESLGGICLNWGCIPTKALIKSAQVFEYLNHAEDYGIKVQGGEADFDAIVKRSRGVADGMSKGIQFLMKKNKIDVINGTAKIKKGGKVEVKGADGATKEYTAKHTILATGARSRELPNLPQDGKKIIGYRQALTLPNKPKSMVVVGSGAIGVEFAYFYNAMGTQVTIVEFMDRIVPVEDEEVSKQLEKSLKKAGINILTKSEVQSVDTKGELSKVSIKTAKGVETLEAEIVLSAVGITPNIENIGLEETGVKTDKGRVLVDDFYKTSVEGVYAIGDIVKGQALAHVASAEAITCVEKIKGLHVEAIDYNNIPGCTYCSPEIASVGYTEKAAKEAGYELKVGKFPFSASGKASAAGAKDGFVKVIFDAKYGELLGAHMIGANVTEMIAEIVVARKLETTGHEMIKSVHPHPTMSEAIMEACADAYGEVIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D7VGX7</accession>
    <name>D7VGX7_SPHSI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0766_10246</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphingobacterium spiritivorum ATCC 33861</name>
        <dbReference type="NCBI Taxonomy" id="525373"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Sphingobacteriia</taxon>
            <taxon>Sphingobacteriales</taxon>
            <taxon>Sphingobacteriaceae</taxon>
            <taxon>Sphingobacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzny D."/>
                <person name="Qin X."/>
                <person name="Buhay C."/>
                <person name="Dugan-Rocha S."/>
                <person name="Ding Y."/>
                <person name="Chen G."/>
                <person name="Hawes A."/>
                <person name="Holder M."/>
                <person name="Jhangiani S."/>
                <person name="Johnson A."/>
                <person name="Khan Z."/>
                <person name="Li Z."/>
                <person name="Liu W."/>
                <person name="Liu X."/>
                <person name="Perez L."/>
                <person name="Shen H."/>
                <person name="Wang Q."/>
                <person name="Watt J."/>
                <person name="Xi L."/>
                <person name="Xin Y."/>
                <person name="Zhou J."/>
                <person name="Deng J."/>
                <person name="Jiang H."/>
                <person name="Liu Y."/>
                <person name="Qu J."/>
                <person name="Song X.-Z."/>
                <person name="Zhang L."/>
                <person name="Villasana D."/>
                <person name="Johnson A."/>
                <person name="Liu J."/>
                <person name="Liyanage D."/>
                <person name="Lorensuhewa L."/>
                <person name="Robinson T."/>
                <person name="Song A."/>
                <person name="Song B.-B."/>
                <person name="Dinh H."/>
                <person name="Thornton R."/>
                <person name="Coyle M."/>
                <person name="Francisco L."/>
                <person name="Jackson L."/>
                <person name="Javaid M."/>
                <person name="Korchina V."/>
                <person name="Kovar C."/>
                <person name="Mata R."/>
                <person name="Mathew T."/>
                <person name="Ngo R."/>
                <person name="Nguyen L."/>
                <person name="Nguyen N."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Pham C."/>
                <person name="Simmons D."/>
                <person name="Wilczek-Boney K."/>
                <person name="Hale W."/>
                <person name="Jakkamsetti A."/>
                <person name="Pham P."/>
                <person name="Ruth R."/>
                <person name="San Lucas F."/>
                <person name="Warren J."/>
                <person name="Zhang J."/>
                <person name="Zhao Z."/>
                <person name="Zhou C."/>
                <person name="Zhu D."/>
                <person name="Lee S."/>
                <person name="Bess C."/>
                <person name="Blankenburg K."/>
                <person name="Forbes L."/>
                <person name="Fu Q."/>
                <person name="Gubbala S."/>
                <person name="Hirani K."/>
                <person name="Jayaseelan J.C."/>
                <person name="Lara F."/>
                <person name="Munidasa M."/>
                <person name="Palculict T."/>
                <person name="Patil S."/>
                <person name="Pu L.-L."/>
                <person name="Saada N."/>
                <person name="Tang L."/>
                <person name="Weissenberger G."/>
                <person name="Zhu Y."/>
                <person name="Hemphill L."/>
                <person name="Shang Y."/>
                <person name="Youmans B."/>
                <person name="Ayvaz T."/>
                <person name="Ross M."/>
                <person name="Santibanez J."/>
                <person name="Aqrawi P."/>
                <person name="Gross S."/>
                <person name="Joshi V."/>
                <person name="Fowler G."/>
                <person name="Nazareth L."/>
        